Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Wayne Isaac Lencer, M.D.


Available: 01/10/22, Expires: 01/01/25

One project of the Lencer lab aims to understand how the epithelial-specific endoplasmic reticulum (ER) stress sensor IRE1beta (ERN2) and its ubiquitously expressed paralogue IRE1alpha (ERN1) contribute to intestinal homeostasis and host defense. ER stress is implicated in the chronic inflammatory and other intestinal diseases. The outcomes of these studies will be informative of the host-microbiota interactions that regulate epithelial development and host defense. These projects offer excellent teaching platforms for students to learn research skills related to molecular biology; protein expression and purification; protein characterization, protein-protein interactions, and enzyme kinetics; mammalian cell culture (in particular with intestinal epithelial cells); in vivo models of microbial colonization and intestinal injury; and molecular and histologic analysis of inflammation. Students do not need to have prior research experience in these areas, but they must have a working understanding of biochemistry, cell biology, and general chemistry concepts from undergraduate and medical school coursework. Students will be supervised by both HMS faculty members Drs. Michael Grey PhD and Wayne Lencer MD and work closely with other members of our research team to learn new techniques, conduct experiments, and record and present their results. They will participate in weekly lab meetings and present results from their project at the end of the appointment. In addition, students will have access to seminars and enrichment opportunities offered through the Division of Gastroenterology and Nutrition, the Harvard Digestive Disease Center, and the entire Boston Children?s Hospital and Longwood Medical Area community.

Cholera Toxin Endocytosis Via Ganglioside GM1 Enriched Detergent-Insoluble Membrane Microdomains: Molecular Mechanisms
Part Time/Continuation, 09/01/98 - 04/01/99

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01DK122953 (LENCER, WAYNE I) Jul 1, 2020 - May 31, 2024
    Mechanisms of action for the IBD-risk gene INAVA: an epithelial guard receptor for inflammation and integrity of the intestinal barrier
    Role: Principal Investigator
  2. RC2DK118640 (MARTIN, MARTIN G) Sep 15, 2019 - Jun 30, 2024
    COngenital Diarrhea and Enteropathy (PediCODE) Consortium and BioRepository
    Role: Co-Principal Investigator
  3. R01DK104868 (LENCER, WAYNE I) Jul 4, 2016 - Jun 30, 2021
    Harnessing the biology of glycosphingolipid trafficking for biologic drug delivery
    Role: Co-Principal Investigator
  4. R21DK090603 (LENCER, WAYNE) Sep 30, 2010 - Aug 31, 2013
    Unsaturated glycoceramide as novel platform for mucosal vaccine and drug delivery
    Role: Principal Investigator
  5. R01DK084424 (LENCER, WAYNE I) Sep 1, 2009 - Aug 31, 2016
    FcRn-dependent sorting of IgG and IgG-opsinized antigens by epithelial cells
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Grey MJ, De Luca H, Ward DV, Kreulen IA, Bugda Gwilt K, Foley SE, Thiagarajah JR, McCormick BA, Turner JR, Lencer WI. The epithelial-specific ER stress sensor ERN2/IRE1ß enables host-microbiota crosstalk to affect colon goblet cell development. J Clin Invest. 2022 09 01; 132(17). PMID: 35727638; PMCID: PMC9435652.
    Citations:    Fields:    
  2. Schmieder SS, Tatituri R, Anderson M, Kelly K, Lencer WI. Structural basis for acyl chain control over glycosphingolipid sorting and vesicular trafficking. Cell Rep. 2022 07 12; 40(2):111063. PMID: 35830800; PMCID: PMC9358721.
    Citations:    Fields:    
  3. Maeda K, Zachos NC, Orzalli MH, Schmieder SS, Chang D, Bugda Gwilt K, Doucet M, Baetz NW, Lee S, Crawford SE, Estes MK, Kagan JC, Turner JR, Lencer WI. Depletion of the apical endosome in response to viruses and bacterial toxins provides cell-autonomous host defense at mucosal surfaces. Cell Host Microbe. 2022 02 09; 30(2):216-231.e5. PMID: 35143768; PMCID: PMC8852832.
    Citations:    Fields:    Translation:Cells
  4. Gustafsson JK, Davis JE, Rappai T, McDonald KG, Kulkarni DH, Knoop KA, Hogan SP, Fitzpatrick JA, Lencer WI, Newberry RD. Intestinal goblet cells sample and deliver lumenal antigens by regulated endocytic uptake and transcytosis. Elife. 2021 10 22; 10. PMID: 34677124; PMCID: PMC8594945.
    Citations: 1     Fields:    Translation:AnimalsCells
  5. Kenworthy AK, Schmieder SS, Raghunathan K, Tiwari A, Wang T, Kelly CV, Lencer WI. Cholera Toxin as a Probe for Membrane Biology. Toxins (Basel). 2021 08 03; 13(8). PMID: 34437414; PMCID: PMC8402489.
    Citations: 4     Fields:    Translation:Cells
  6. Chang D, Luong P, Li Q, LeBarron J, Anderson M, Barrett L, Lencer WI. Small-molecule modulators of INAVA cytosolic condensate and cell-cell junction assemblies. J Cell Biol. 2021 09 06; 220(9). PMID: 34251416; PMCID: PMC8276315.
    Citations: 1     Fields:    Translation:HumansCells
  7. Arumugam S, Schmieder S, Pezeshkian W, Becken U, Wunder C, Chinnapen D, Ipsen JH, Kenworthy AK, Lencer W, Mayor S, Johannes L. Ceramide structure dictates glycosphingolipid nanodomain assembly and function. Nat Commun. 2021 06 16; 12(1):3675. PMID: 34135326.
    Citations: 4     Fields:    Translation:Cells
  8. Cloots E, Simpson MS, De Nolf C, Lencer WI, Janssens S, Grey MJ. Evolution and function of the epithelial cell-specific ER stress sensor IRE1ß. Mucosal Immunol. 2021 11; 14(6):1235-1246. PMID: 34075183; PMCID: PMC8528705.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  9. Chang D, Whiteley AT, Bugda Gwilt K, Lencer WI, Mekalanos JJ, Thiagarajah JR. Extracellular cyclic dinucleotides induce polarized responses in barrier epithelial cells by adenosine signaling. Proc Natl Acad Sci U S A. 2020 11 03; 117(44):27502-27508. PMID: 33087577.
    Citations: 7     Fields:    Translation:HumansCells
  10. Simpson MS, Lencer WI, Luong P. A Quantitative Single-cell Flow Cytometry Assay for Retrograde MembraneTrafficking Using Engineered Cholera Toxin. Bio Protoc. 2020 Aug 05; 10(15):e3707. PMID: 33659371; PMCID: PMC7842762.
    Citations: 1     
  11. Lencer WI. Everything Illuminated-Clostridium perfringens ß-toxin. Cell Host Microbe. 2020 07 08; 28(1):5-6. PMID: 32645353.
    Citations:    Fields:    Translation:Cells
  12. Kabbani AM, Raghunathan K, Lencer WI, Kenworthy AK, Kelly CV. Structured clustering of the glycosphingolipid GM1 is required for membrane curvature induced by cholera toxin. Proc Natl Acad Sci U S A. 2020 06 30; 117(26):14978-14986. PMID: 32554490.
    Citations: 20     Fields:    Translation:AnimalsCells
  13. Duclos RI, Blue KD, Rufo MJ, Chen X, Guo JJ, Ma X, Lencer WI, Chinnapen DJF. Conjugation of peptides to short-acyl-chain ceramides for delivery across mucosal cell barriers. Bioorg Med Chem Lett. 2020 04 15; 30(8):127014. PMID: 32081448.
    Citations:    Fields:    Translation:HumansCells
  14. Grey MJ, Cloots E, Simpson MS, LeDuc N, Serebrenik YV, De Luca H, De Sutter D, Luong P, Thiagarajah JR, Paton AW, Paton JC, Seeliger MA, Eyckerman S, Janssens S, Lencer WI. IRE1ß negatively regulates IRE1a signaling in response to endoplasmic reticulum stress. J Cell Biol. 2020 Feb 03; 219(2). PMID: 31985747; PMCID: PMC7041686.
    Citations: 8     Fields:    Translation:HumansCells
  15. Luong P, Li Q, Chen PF, Wrighton PJ, Chang D, Dwyer S, Bayer MT, Snapper SB, Hansen SH, Thiagarajah JR, Goessling W, Lencer WI. A quantitative single-cell assay for retrograde membrane traffic enables rapid detection of defects in cellular organization. Mol Biol Cell. 2020 03 19; 31(7):511-519. PMID: 31774722.
    Citations: 3     Fields:    Translation:HumansCells
  16. Royal JM, Oh YJ, Grey MJ, Lencer WI, Ronquillo N, Galandiuk S, Matoba N. A modified cholera toxin B subunit containing an ER retention motif enhances colon epithelial repair via an unfolded protein response. FASEB J. 2019 12; 33(12):13527-13545. PMID: 31560862; PMCID: PMC9272749.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  17. Luong P, Hedl M, Yan J, Zuo T, Fu TM, Jiang X, Thiagarajah JR, Hansen SH, Lesser CF, Wu H, Abraham C, Lencer WI. INAVA-ARNO complexes bridge mucosal barrier function with inflammatory signaling. Elife. 2018 10 25; 7. PMID: 30355448.
    Citations: 7     Fields:    Translation:HumansCells
  18. Garcia-Castillo MD, Lencer WI, Chinnapen DJ. Transcytosis Assay for Transport of Glycosphingolipids across MDCK-II Cells. Bio Protoc. 2018 Oct 20; 8(20):e2018. PMID: 34532518.
  19. Garcia-Castillo MD, Lencer WI, Chinnapen DJ. Transcytosis Assay for Transport of Glycosphingolipids across MDCK-II Cells. Bio Protoc. 2018 10 20; 8(20). PMID: 30505885; PMCID: PMC6261372.
    Citations: 4     
  20. Pacheco AR, Lazarus JE, Sit B, Schmieder S, Lencer WI, Blondel CJ, Doench JG, Davis BM, Waldor MK. CRISPR Screen Reveals that EHEC's T3SS and Shiga Toxin Rely on Shared Host Factors for Infection. mBio. 2018 06 19; 9(3). PMID: 29921669; PMCID: PMC6016243.
    Citations: 25     Fields:    Translation:HumansCells
  21. Garcia-Castillo MD, Chinnapen DJ, Te Welscher YM, Gonzalez RJ, Softic S, Pacheco M, Mrsny RJ, Kahn CR, von Andrian UH, Lau J, Pentelute BL, Lencer WI. Mucosal absorption of therapeutic peptides by harnessing the endogenous sorting of glycosphingolipids. Elife. 2018 05 31; 7. PMID: 29851380; PMCID: PMC5980230.
    Citations: 7     Fields:    Translation:AnimalsCells
  22. Thiagarajah JR, Kamin DS, Acra S, Goldsmith JD, Roland JT, Lencer WI, Muise AM, Goldenring JR, Avitzur Y, Martín MG. Advances in Evaluation of Chronic Diarrhea in Infants. Gastroenterology. 2018 Jun; 154(8):2045-2059.e6. PMID: 29654747; PMCID: PMC6044208.
    Citations: 40     Fields:    Translation:HumansCells
  23. Cho JA, Lee AH, Platzer B, Cross BCS, Gardner BM, De Luca H, Luong P, Harding HP, Glimcher LH, Walter P, Fiebiger E, Ron D, Kagan JC, Lencer WI. Retraction Notice to: The Unfolded Protein Response Element IRE1a Senses Bacterial Proteins Invading the ER to Activate RIG-I and Innate Immune Signaling. Cell Host Microbe. 2018 04 11; 23(4):571. PMID: 29649448; PMCID: PMC5916756.
    Citations: 1     Fields:    
  24. Garcia-Castillo MD, Chinnapen DJ, Lencer WI. Membrane Transport across Polarized Epithelia. Cold Spring Harb Perspect Biol. 2017 Sep 01; 9(9). PMID: 28213463; PMCID: PMC5585844.
    Citations: 23     Fields:    Translation:HumansCells
  25. Pyzik M, Rath T, Kuo TT, Win S, Baker K, Hubbard JJ, Grenha R, Gandhi A, Krämer TD, Mezo AR, Taylor ZS, McDonnell K, Nienaber V, Andersen JT, Mizoguchi A, Blumberg L, Purohit S, Jones SD, Christianson G, Lencer WI, Sandlie I, Kaplowitz N, Roopenian DC, Blumberg RS. Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury. Proc Natl Acad Sci U S A. 2017 04 04; 114(14):E2862-E2871. PMID: 28330995; PMCID: PMC5389309.
    Citations: 39     Fields:    Translation:AnimalsCells
  26. Nelms B, Dalomba NF, Lencer W. A targeted RNAi screen identifies factors affecting diverse stages of receptor-mediated transcytosis. J Cell Biol. 2017 02; 216(2):511-525. PMID: 28069747; PMCID: PMC5294788.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  27. Thiagarajah JR, Chang J, Goettel JA, Verkman AS, Lencer WI. Aquaporin-3 mediates hydrogen peroxide-dependent responses to environmental stress in colonic epithelia. Proc Natl Acad Sci U S A. 2017 01 17; 114(3):568-573. PMID: 28049834; PMCID: PMC5255594.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  28. Raghunathan K, Wong TH, Chinnapen DJ, Lencer WI, Jobling MG, Kenworthy AK. Glycolipid Crosslinking Is Required for Cholera Toxin to Partition Into and Stabilize Ordered Domains. Biophys J. 2016 Dec 20; 111(12):2547-2550. PMID: 27914621; PMCID: PMC5192692.
    Citations: 14     Fields:    Translation:AnimalsCells
  29. Nelms BD, Waldron L, Barrera LA, Weflen AW, Goettel JA, Guo G, Montgomery RK, Neutra MR, Breault DT, Snapper SB, Orkin SH, Bulyk ML, Huttenhower C, Lencer WI. CellMapper: rapid and accurate inference of gene expression in difficult-to-isolate cell types. Genome Biol. 2016 09 29; 17(1):201. PMID: 27687735; PMCID: PMC5043525.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  30. Lencer WI. Opening CFTR in the Intestine: Flushing on Demand. Cell Mol Gastroenterol Hepatol. 2016 May; 2(3):256. PMID: 28174716.
    Citations: 1     Fields:    
  31. Saslowsky DE, Thiagarajah JR, McCormick BA, Lee JC, Lencer WI. Microbial sphingomyelinase induces RhoA-mediated reorganization of the apical brush border membrane and is protective against invasion. Mol Biol Cell. 2016 Apr 01; 27(7):1120-30. PMID: 26864627; PMCID: PMC4814219.
    Citations: 4     Fields:    Translation:HumansCells
  32. Lexmond WS, Rufo PA, Fiebiger E, Lencer WI. Electrophysiological Studies into the Safety of the Anti-diarrheal Drug Clotrimazole during Oral Rehydration Therapy. PLoS Negl Trop Dis. 2015 Sep; 9(9):e0004098. PMID: 26405813.
    Citations:    Fields:    Translation:AnimalsCells
  33. Reimold FR, Balasubramanian S, Doroquez DB, Shmukler BE, Zsengeller ZK, Saslowsky D, Thiagarajah JR, Stillman IE, Lencer WI, Wu BL, Villalpando-Carrion S, Alper SL. Congenital chloride-losing diarrhea in a Mexican child with the novel homozygous SLC26A3 mutation G393W. Front Physiol. 2015; 6:179. PMID: 26157392; PMCID: PMC4477073.
    Citations: 3     
  34. Lencer WI, DeLuca H, Grey MJ, Cho JA. Innate immunity at mucosal surfaces: the IRE1-RIDD-RIG-I pathway. Trends Immunol. 2015 Jul; 36(7):401-9. PMID: 26093676; PMCID: PMC4490948.
    Citations: 21     Fields:    Translation:HumansCells
  35. Pyzik M, Rath T, Lencer WI, Baker K, Blumberg RS. FcRn: The Architect Behind the Immune and Nonimmune Functions of IgG and Albumin. J Immunol. 2015 May 15; 194(10):4595-603. PMID: 25934922; PMCID: PMC4451002.
    Citations: 92     Fields:    Translation:HumansAnimals
  36. Day CA, Baetz NW, Copeland CA, Kraft LJ, Han B, Tiwari A, Drake KR, De Luca H, Chinnapen DJ, Davidson MW, Holmes RK, Jobling MG, Schroer TA, Lencer WI, Kenworthy AK. Microtubule motors power plasma membrane tubulation in clathrin-independent endocytosis. Traffic. 2015 Jun; 16(6):572-90. PMID: 25690058.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  37. Cho JA, Zhang X, Miller GM, Lencer WI, Nery FC. 4-Phenylbutyrate attenuates the ER stress response and cyclic AMP accumulation in DYT1 dystonia cell models. PLoS One. 2014; 9(11):e110086. PMID: 25379658.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  38. Zhou X, Massol RH, Nakamura F, Chen X, Gewurz BE, Davis BM, Lencer WI, Waldor MK. Remodeling of the intestinal brush border underlies adhesion and virulence of an enteric pathogen. mBio. 2014 Aug 19; 5(4). PMID: 25139905.
    Citations: 17     Fields:    Translation:AnimalsCells
  39. Luo R, Jeong SJ, Yang A, Wen M, Saslowsky DE, Lencer WI, Araç D, Piao X. Mechanism for adhesion G protein-coupled receptor GPR56-mediated RhoA activation induced by collagen III stimulation. PLoS One. 2014; 9(6):e100043. PMID: 24949629.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  40. te Welscher YM, Chinnapen DJ, Kaoutzani L, Mrsny RJ, Lencer WI. Unsaturated glycoceramides as molecular carriers for mucosal drug delivery of GLP-1. J Control Release. 2014 Feb 10; 175:72-8. PMID: 24370893.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  41. Baker K, Rath T, Flak MB, Arthur JC, Chen Z, Glickman JN, Zlobec I, Karamitopoulou E, Stachler MD, Odze RD, Lencer WI, Jobin C, Blumberg RS. Neonatal Fc receptor expression in dendritic cells mediates protective immunity against colorectal cancer. Immunity. 2013 Dec 12; 39(6):1095-107. PMID: 24290911.
    Citations: 58     Fields:    Translation:HumansAnimalsCells
  42. Rath T, Baker K, Dumont JA, Peters RT, Jiang H, Qiao SW, Lencer WI, Pierce GF, Blumberg RS. Fc-fusion proteins and FcRn: structural insights for longer-lasting and more effective therapeutics. Crit Rev Biotechnol. 2015 Jun; 35(2):235-54. PMID: 24156398.
    Citations: 99     Fields:    Translation:HumansAnimals
  43. Saslowsky DE, Te Welscher YM, Chinnapen DJ, Wagner JS, Wan J, Kern E, Lencer WI. Ganglioside GM1-mediated transcytosis of cholera toxin bypasses the retrograde pathway and depends on the structure of the ceramide domain. J Biol Chem. 2013 Sep 06; 288(36):25804-25809. PMID: 23884419.
    Citations: 19     Fields:    Translation:AnimalsCells
  44. Weflen AW, Baier N, Tang QJ, Van den Hof M, Blumberg RS, Lencer WI, Massol RH. Multivalent immune complexes divert FcRn to lysosomes by exclusion from recycling sorting tubules. Mol Biol Cell. 2013 Aug; 24(15):2398-405. PMID: 23741050.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  45. Cho JA, Lee AH, Platzer B, Cross BCS, Gardner BM, De Luca H, Luong P, Harding HP, Glimcher LH, Walter P, Fiebiger E, Ron D, Kagan JC, Lencer WI. The unfolded protein response element IRE1a senses bacterial proteins invading the ER to activate RIG-I and innate immune signaling. Cell Host Microbe. 2013 May 15; 13(5):558-569. PMID: 23684307; PMCID: PMC3766372.
    Citations: 63     Fields:    Translation:HumansCells
  46. Jobling MG, Yang Z, Kam WR, Lencer WI, Holmes RK. A single native ganglioside GM1-binding site is sufficient for cholera toxin to bind to cells and complete the intoxication pathway. mBio. 2012 Oct 30; 3(6). PMID: 23111873.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  47. Chinnapen DJ, Hsieh WT, te Welscher YM, Saslowsky DE, Kaoutzani L, Brandsma E, D'Auria L, Park H, Wagner JS, Drake KR, Kang M, Benjamin T, Ullman MD, Costello CE, Kenworthy AK, Baumgart T, Massol RH, Lencer WI. Lipid sorting by ceramide structure from plasma membrane to ER for the cholera toxin receptor ganglioside GM1. Dev Cell. 2012 Sep 11; 23(3):573-86. PMID: 22975326.
    Citations: 54     Fields:    Translation:HumansCells
  48. Rath T, Kuo TT, Baker K, Qiao SW, Kobayashi K, Yoshida M, Roopenian D, Fiebiger E, Lencer WI, Blumberg RS. The immunologic functions of the neonatal Fc receptor for IgG. J Clin Immunol. 2013 Jan; 33 Suppl 1:S9-17. PMID: 22948741.
    Citations: 55     Fields:    Translation:HumansAnimalsCells
  49. Baker K, Rath T, Lencer WI, Fiebiger E, Blumberg RS. Cross-presentation of IgG-containing immune complexes. Cell Mol Life Sci. 2013 Apr; 70(8):1319-34. PMID: 22847331.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  50. Cho JA, Chinnapen DJ, Aamar E, te Welscher YM, Lencer WI, Massol R. Insights on the trafficking and retro-translocation of glycosphingolipid-binding bacterial toxins. Front Cell Infect Microbiol. 2012; 2:51. PMID: 22919642.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  51. Lencer WI, von Andrian UH. Eliciting mucosal immunity. N Engl J Med. 2011 Sep 22; 365(12):1151-3. PMID: 21992128; PMCID: PMC4868065.
    Citations: 2     Fields:    Translation:HumansCells
  52. Lencer WI, Tweten RK. To translocate or not: that is the problem. Cell Host Microbe. 2011 Sep 15; 10(3):179-80. PMID: 21925105.
    Citations:    Fields:    
  53. Fortin JP, Chinnapen D, Beinborn M, Lencer W, Kopin AS. Discovery of dual-action membrane-anchored modulators of incretin receptors. PLoS One. 2011; 6(9):e24693. PMID: 21935440.
    Citations: 10     Fields:    Translation:HumansCells
  54. Uchida Y, Hasegawa J, Chinnapen D, Inoue T, Okazaki S, Kato R, Wakatsuki S, Misaki R, Koike M, Uchiyama Y, Iemura S, Natsume T, Kuwahara R, Nakagawa T, Nishikawa K, Mukai K, Miyoshi E, Taniguchi N, Sheff D, Lencer WI, Taguchi T, Arai H. Intracellular phosphatidylserine is essential for retrograde membrane traffic through endosomes. Proc Natl Acad Sci U S A. 2011 Sep 20; 108(38):15846-51. PMID: 21911378.
    Citations: 72     Fields:    Translation:HumansAnimalsCells
  55. Nery FC, Armata IA, Farley JE, Cho JA, Yaqub U, Chen P, da Hora CC, Wang Q, Tagaya M, Klein C, Tannous B, Caldwell KA, Caldwell GA, Lencer WI, Ye Y, Breakefield XO. TorsinA participates in endoplasmic reticulum-associated degradation. Nat Commun. 2011 Jul 12; 2:393. PMID: 21750546.
    Citations: 60     Fields:    Translation:HumansAnimalsCells
  56. Baker K, Qiao SW, Kuo TT, Aveson VG, Platzer B, Andersen JT, Sandlie I, Chen Z, de Haar C, Lencer WI, Fiebiger E, Blumberg RS. Neonatal Fc receptor for IgG (FcRn) regulates cross-presentation of IgG immune complexes by CD8-CD11b+ dendritic cells. Proc Natl Acad Sci U S A. 2011 Jun 14; 108(24):9927-32. PMID: 21628593.
    Citations: 103     Fields:    Translation:AnimalsCells
  57. Gupta V, Kawahara G, Gundry SR, Chen AT, Lencer WI, Zhou Y, Zon LI, Kunkel LM, Beggs AH. The zebrafish dag1 mutant: a novel genetic model for dystroglycanopathies. Hum Mol Genet. 2011 May 01; 20(9):1712-25. PMID: 21296866.
    Citations: 55     Fields:    Translation:HumansAnimalsCells
  58. Tam VC, Suzuki M, Coughlin M, Saslowsky D, Biswas K, Lencer WI, Faruque SM, Mekalanos JJ. Functional analysis of VopF activity required for colonization in Vibrio cholerae. mBio. 2010 Dec 07; 1(5). PMID: 21151774.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  59. Saslowsky DE, Cho JA, Chinnapen H, Massol RH, Chinnapen DJ, Wagner JS, De Luca HE, Kam W, Paw BH, Lencer WI. Intoxication of zebrafish and mammalian cells by cholera toxin depends on the flotillin/reggie proteins but not Derlin-1 or -2. J Clin Invest. 2010 Dec; 120(12):4399-4409. PMID: 21041954; PMCID: PMC2994338.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  60. Kuo TT, Baker K, Yoshida M, Qiao SW, Aveson VG, Lencer WI, Blumberg RS. Neonatal Fc receptor: from immunity to therapeutics. J Clin Immunol. 2010 Nov; 30(6):777-89. PMID: 20886282.
    Citations: 89     Fields:    Translation:HumansAnimals
  61. Wernick NL, Chinnapen DJ, Cho JA, Lencer WI. Cholera toxin: an intracellular journey into the cytosol by way of the endoplasmic reticulum. Toxins (Basel). 2010 03; 2(3):310-25. PMID: 22069586.
    Citations: 90     Fields:    Translation:HumansCells
  62. Eby JC, Ciesla WP, Hamman W, Donato GM, Pickles RJ, Hewlett EL, Lencer WI. Selective translocation of the Bordetella pertussis adenylate cyclase toxin across the basolateral membranes of polarized epithelial cells. J Biol Chem. 2010 Apr 02; 285(14):10662-70. PMID: 20139088.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  63. Wernick NL, De Luca H, Kam WR, Lencer WI. N-terminal extension of the cholera toxin A1-chain causes rapid degradation after retrotranslocation from endoplasmic reticulum to cytosol. J Biol Chem. 2010 Feb 26; 285(9):6145-52. PMID: 20056601.
    Citations: 24     Fields:    Translation:AnimalsCells
  64. Kobayashi K, Qiao SW, Yoshida M, Baker K, Lencer WI, Blumberg RS. An FcRn-dependent role for anti-flagellin immunoglobulin G in pathogenesis of colitis in mice. Gastroenterology. 2009 Nov; 137(5):1746-56.e1. PMID: 19664634; PMCID: PMC2787451.
    Citations: 40     Fields:    Translation:AnimalsCells
  65. Baker K, Qiao SW, Kuo T, Kobayashi K, Yoshida M, Lencer WI, Blumberg RS. Immune and non-immune functions of the (not so) neonatal Fc receptor, FcRn. Semin Immunopathol. 2009 Jul; 31(2):223-36. PMID: 19495758.
    Citations: 38     Fields:    Translation:HumansAnimals
  66. Tzaban S, Massol RH, Yen E, Hamman W, Frank SR, Lapierre LA, Hansen SH, Goldenring JR, Blumberg RS, Lencer WI. The recycling and transcytotic pathways for IgG transport by FcRn are distinct and display an inherent polarity. J Cell Biol. 2009 May 18; 185(4):673-84. PMID: 19451275.
    Citations: 87     Fields:    Translation:HumansAnimalsCells
  67. Kuo TT, de Muinck EJ, Claypool SM, Yoshida M, Nagaishi T, Aveson VG, Lencer WI, Blumberg RS. N-Glycan Moieties in Neonatal Fc Receptor Determine Steady-state Membrane Distribution and Directional Transport of IgG. J Biol Chem. 2009 Mar 27; 284(13):8292-300. PMID: 19164298.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  68. Saslowsky DE, Tanaka N, Reddy KP, Lencer WI. Ceramide activates JNK to inhibit a cAMP-gated K+ conductance and Cl- secretion in intestinal epithelia. FASEB J. 2009 Jan; 23(1):259-70. PMID: 18820034; PMCID: PMC2626619.
    Citations: 5     Fields:    Translation:HumansCells
  69. Lencer WI. Patching a leaky intestine. N Engl J Med. 2008 Jul 31; 359(5):526-8. PMID: 18669433; PMCID: PMC3521046.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  70. Qiao SW, Kobayashi K, Johansen FE, Sollid LM, Andersen JT, Milford E, Roopenian DC, Lencer WI, Blumberg RS. Dependence of antibody-mediated presentation of antigen on FcRn. Proc Natl Acad Sci U S A. 2008 Jul 08; 105(27):9337-42. PMID: 18599440.
    Citations: 121     Fields:    Translation:HumansAnimalsCells
  71. Wolf AA, Jobling MG, Saslowsky DE, Kern E, Drake KR, Kenworthy AK, Holmes RK, Lencer WI. Attenuated endocytosis and toxicity of a mutant cholera toxin with decreased ability to cluster ganglioside GM1 molecules. Infect Immun. 2008 Apr; 76(4):1476-84. PMID: 18212085.
    Citations: 33     Fields:    Translation:HumansCells
  72. Saslowsky DE, Lencer WI. Conversion of apical plasma membrane sphingomyelin to ceramide attenuates the intoxication of host cells by cholera toxin. Cell Microbiol. 2008 Jan; 10(1):67-80. PMID: 18052945.
    Citations: 13     Fields:    Translation:HumansCells
  73. Bernardi KM, Forster ML, Lencer WI, Tsai B. Derlin-1 facilitates the retro-translocation of cholera toxin. Mol Biol Cell. 2008 Mar; 19(3):877-84. PMID: 18094046.
    Citations: 59     Fields:    Translation:HumansCells
  74. Dickinson BL, Claypool SM, D'Angelo JA, Aiken ML, Venu N, Yen EH, Wagner JS, Borawski JA, Pierce AT, Hershberg R, Blumberg RS, Lencer WI. Ca2+-dependent calmodulin binding to FcRn affects immunoglobulin G transport in the transcytotic pathway. Mol Biol Cell. 2008 Jan; 19(1):414-23. PMID: 18003977.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  75. Matsumura T, Jin Y, Kabumoto Y, Takegahara Y, Oguma K, Lencer WI, Fujinaga Y. The HA proteins of botulinum toxin disrupt intestinal epithelial intercellular junctions to increase toxin absorption. Cell Microbiol. 2008 Feb; 10(2):355-64. PMID: 17868282.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  76. Chinnapen DJ, Chinnapen H, Saslowsky D, Lencer WI. Rafting with cholera toxin: endocytosis and trafficking from plasma membrane to ER. FEMS Microbiol Lett. 2007 Jan; 266(2):129-37. PMID: 17156122; PMCID: PMC3511785.
    Citations: 111     Fields:    Translation:HumansAnimalsCells
  77. Qiao SW, Lencer WI, Blumberg RS. How the controller is controlled - neonatal Fc receptor expression and immunoglobulin G homeostasis. Immunology. 2007 Feb; 120(2):145-7. PMID: 17140402.
    Citations: 6     Fields:    Translation:HumansAnimals
  78. Yoshida M, Masuda A, Kuo TT, Kobayashi K, Claypool SM, Takagawa T, Kutsumi H, Azuma T, Lencer WI, Blumberg RS. IgG transport across mucosal barriers by neonatal Fc receptor for IgG and mucosal immunity. Springer Semin Immunopathol. 2006 Dec; 28(4):397-403. PMID: 17051393.
    Citations: 28     Fields:    Translation:HumansCells
  79. Yoshida M, Kobayashi K, Kuo TT, Bry L, Glickman JN, Claypool SM, Kaser A, Nagaishi T, Higgins DE, Mizoguchi E, Wakatsuki Y, Roopenian DC, Mizoguchi A, Lencer WI, Blumberg RS. Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria. J Clin Invest. 2006 Aug; 116(8):2142-2151. PMID: 16841095; PMCID: PMC1501111.
    Citations: 112     Fields:    Translation:Animals
  80. Forster ML, Sivick K, Park YN, Arvan P, Lencer WI, Tsai B. Protein disulfide isomerase-like proteins play opposing roles during retrotranslocation. J Cell Biol. 2006 Jun 19; 173(6):853-9. PMID: 16785320; PMCID: PMC2063911.
    Citations: 61     Fields:    Translation:HumansCells
  81. Shen L, Black ED, Witkowski ED, Lencer WI, Guerriero V, Schneeberger EE, Turner JR. Myosin light chain phosphorylation regulates barrier function by remodeling tight junction structure. J Cell Sci. 2006 May 15; 119(Pt 10):2095-106. PMID: 16638813.
    Citations: 172     Fields:    Translation:HumansCells
  82. Pelish HE, Ciesla W, Tanaka N, Reddy K, Shair MD, Kirchhausen T, Lencer WI. The Cdc42 inhibitor secramine B prevents cAMP-induced K+ conductance in intestinal epithelial cells. Biochem Pharmacol. 2006 Jun 14; 71(12):1720-6. PMID: 16677615.
    Citations: 6     Fields:    Translation:HumansCells
  83. Wang X, Ye Y, Lencer W, Hansen TH. The viral E3 ubiquitin ligase mK3 uses the Derlin/p97 endoplasmic reticulum-associated degradation pathway to mediate down-regulation of major histocompatibility complex class I proteins. J Biol Chem. 2006 Mar 31; 281(13):8636-44. PMID: 16446359.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  84. De Luca HE, Lencer WI. A biochemical method for tracking cholera toxin transport from plasma membrane to Golgi and endoplasmic reticulum. Methods Mol Biol. 2006; 341:127-39. PMID: 16799195.
    Citations: 3     Fields:    Translation:AnimalsCells
  85. Blumberg RS, Lencer WI. Antibodies in the breakdown lane. Nat Biotechnol. 2005 Oct; 23(10):1232-4. PMID: 16211062.
    Citations: 3     Fields:    Translation:HumansAnimals
  86. Lencer WI, Saslowsky D. Raft trafficking of AB5 subunit bacterial toxins. Biochim Biophys Acta. 2005 Dec 30; 1746(3):314-21. PMID: 16153723.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  87. Zhu X, Peng J, Chen D, Liu X, Ye L, Iijima H, Kadavil K, Lencer WI, Blumberg RS. Calnexin and ERp57 facilitate the assembly of the neonatal Fc receptor for IgG with beta 2-microglobulin in the endoplasmic reticulum. J Immunol. 2005 Jul 15; 175(2):967-76. PMID: 16002696.
    Citations: 9     Fields:    Translation:HumansCells
  88. Kothe M, Ye Y, Wagner JS, De Luca HE, Kern E, Rapoport TA, Lencer WI. Role of p97 AAA-ATPase in the retrotranslocation of the cholera toxin A1 chain, a non-ubiquitinated substrate. J Biol Chem. 2005 Jul 29; 280(30):28127-32. PMID: 15932873.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  89. Lencer WI. Signal transduction by bacterial proteins. J Pediatr Gastroenterol Nutr. 2005 Apr; 40 Suppl 1:S33-4. PMID: 15805843.
    Citations:    Fields:    Translation:HumansCells
  90. Stirling CM, Charleston B, Takamatsu H, Claypool S, Lencer W, Blumberg RS, Wileman TE. Characterization of the porcine neonatal Fc receptor--potential use for trans-epithelial protein delivery. Immunology. 2005 Apr; 114(4):542-53. PMID: 15804291.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  91. Lu L, Khan S, Lencer W, Walker WA. Endocytosis of cholera toxin by human enterocytes is developmentally regulated. Am J Physiol Gastrointest Liver Physiol. 2005 Aug; 289(2):G332-41. PMID: 15790757.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  92. Lord JM, Roberts LM, Lencer WI. Entry of protein toxins into mammalian cells by crossing the endoplasmic reticulum membrane: co-opting basic mechanisms of endoplasmic reticulum-associated degradation. Curr Top Microbiol Immunol. 2005; 300:149-68. PMID: 16573240.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  93. Lencer WI, Blumberg RS. A passionate kiss, then run: exocytosis and recycling of IgG by FcRn. Trends Cell Biol. 2005 Jan; 15(1):5-9. PMID: 15653072.
    Citations: 42     Fields:    Translation:Humans
  94. Gilbert J, Dahl J, Riney C, You J, Cui C, Holmes R, Lencer W, Benjamin T. Ganglioside GD1a restores infectibility to mouse cells lacking functional receptors for polyomavirus. J Virol. 2005 Jan; 79(1):615-8. PMID: 15596855; PMCID: PMC538744.
    Citations: 22     Fields:    Translation:AnimalsCells
  95. Badizadegan K, Wheeler HE, Fujinaga Y, Lencer WI. Trafficking of cholera toxin-ganglioside GM1 complex into Golgi and induction of toxicity depend on actin cytoskeleton. Am J Physiol Cell Physiol. 2004 Nov; 287(5):C1453-62. PMID: 15294854.
    Citations: 17     Fields:    Translation:HumansCells
  96. Bitonti AJ, Dumont JA, Low SC, Peters RT, Kropp KE, Palombella VJ, Stattel JM, Lu Y, Tan CA, Song JJ, Garcia AM, Simister NE, Spiekermann GM, Lencer WI, Blumberg RS. Pulmonary delivery of an erythropoietin Fc fusion protein in non-human primates through an immunoglobulin transport pathway. Proc Natl Acad Sci U S A. 2004 Jun 29; 101(26):9763-8. PMID: 15210944; PMCID: PMC470748.
    Citations: 77     Fields:    Translation:HumansAnimalsCells
  97. Yoshida M, Claypool SM, Wagner JS, Mizoguchi E, Mizoguchi A, Roopenian DC, Lencer WI, Blumberg RS. Human neonatal Fc receptor mediates transport of IgG into luminal secretions for delivery of antigens to mucosal dendritic cells. Immunity. 2004 Jun; 20(6):769-83. PMID: 15189741.
    Citations: 178     Fields:    Translation:HumansAnimalsCells
  98. Feng Y, Jadhav AP, Rodighiero C, Fujinaga Y, Kirchhausen T, Lencer WI. Retrograde transport of cholera toxin from the plasma membrane to the endoplasmic reticulum requires the trans-Golgi network but not the Golgi apparatus in Exo2-treated cells. EMBO Rep. 2004 Jun; 5(6):596-601. PMID: 15153932; PMCID: PMC1299072.
    Citations: 44     Fields:    Translation:AnimalsCells
  99. Massol RH, Larsen JE, Fujinaga Y, Lencer WI, Kirchhausen T. Cholera toxin toxicity does not require functional Arf6- and dynamin-dependent endocytic pathways. Mol Biol Cell. 2004 Aug; 15(8):3631-41. PMID: 15146065; PMCID: PMC491824.
    Citations: 35     Fields:    Translation:AnimalsCells
  100. Lencer WI. Retrograde transport of cholera toxin into the ER of host cells. Int J Med Microbiol. 2004 Apr; 293(7-8):491-4. PMID: 15149023.
    Citations: 11     Fields:    Translation:HumansCells
  101. Lin PW, Simon PO, Gewirtz AT, Neish AS, Ouellette AJ, Madara JL, Lencer WI. Paneth cell cryptdins act in vitro as apical paracrine regulators of the innate inflammatory response. J Biol Chem. 2004 May 07; 279(19):19902-7. PMID: 14990585.
    Citations: 16     Fields:    Translation:HumansCells
  102. Claypool SM, Dickinson BL, Wagner JS, Johansen FE, Venu N, Borawski JA, Lencer WI, Blumberg RS. Bidirectional transepithelial IgG transport by a strongly polarized basolateral membrane Fcgamma-receptor. Mol Biol Cell. 2004 Apr; 15(4):1746-59. PMID: 14767057; PMCID: PMC379272.
    Citations: 69     Fields:    Translation:HumansAnimalsCells
  103. Rufo PA, Lin PW, Andrade A, Jiang L, Rameh L, Flexner C, Alper SL, Lencer WI. Diarrhea-associated HIV-1 APIs potentiate muscarinic activation of Cl- secretion by T84 cells via prolongation of cytosolic Ca2+ signaling. Am J Physiol Cell Physiol. 2004 May; 286(5):C998-C1008. PMID: 15075198.
    Citations: 16     Fields:    Translation:HumansCells
  104. Lencer WI, Tsai B. The intracellular voyage of cholera toxin: going retro. Trends Biochem Sci. 2003 Dec; 28(12):639-45. PMID: 14659695.
    Citations: 90     Fields:    Translation:HumansAnimalsCells
  105. Fujinaga Y, Wolf AA, Rodighiero C, Wheeler H, Tsai B, Allen L, Jobling MG, Rapoport T, Holmes RK, Lencer WI. Gangliosides that associate with lipid rafts mediate transport of cholera and related toxins from the plasma membrane to endoplasmic reticulm. Mol Biol Cell. 2003 Dec; 14(12):4783-93. PMID: 13679513; PMCID: PMC284783.
    Citations: 99     Fields:    Translation:HumansAnimalsCells
  106. Tsai B, Gilbert JM, Stehle T, Lencer W, Benjamin TL, Rapoport TA. Gangliosides are receptors for murine polyoma virus and SV40. EMBO J. 2003 Sep 01; 22(17):4346-55. PMID: 12941687; PMCID: PMC202381.
    Citations: 175     Fields:    Translation:HumansAnimalsCells
  107. Yu AS, Enck AH, Lencer WI, Schneeberger EE. Claudin-8 expression in Madin-Darby canine kidney cells augments the paracellular barrier to cation permeation. J Biol Chem. 2003 May 09; 278(19):17350-9. PMID: 12615928.
    Citations: 96     Fields:    Translation:AnimalsCells
  108. Shah U, Dickinson BL, Blumberg RS, Simister NE, Lencer WI, Walker WA. Distribution of the IgG Fc receptor, FcRn, in the human fetal intestine. Pediatr Res. 2003 Feb; 53(2):295-301. PMID: 12538789; PMCID: PMC2819091.
    Citations: 46     Fields:    Translation:HumansCells
  109. Rodighiero C, Tsai B, Rapoport TA, Lencer WI. Role of ubiquitination in retro-translocation of cholera toxin and escape of cytosolic degradation. EMBO Rep. 2002 Dec; 3(12):1222-7. PMID: 12446567; PMCID: PMC1308323.
    Citations: 68     Fields:    Translation:Cells
  110. Zhu X, Peng J, Raychowdhury R, Nakajima A, Lencer WI, Blumberg RS. The heavy chain of neonatal Fc receptor for IgG is sequestered in endoplasmic reticulum by forming oligomers in the absence of beta2-microglobulin association. Biochem J. 2002 Nov 01; 367(Pt 3):703-14. PMID: 12162790; PMCID: PMC1222943.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  111. Spiekermann GM, Finn PW, Ward ES, Dumont J, Dickinson BL, Blumberg RS, Lencer WI. Receptor-mediated immunoglobulin G transport across mucosal barriers in adult life: functional expression of FcRn in the mammalian lung. J Exp Med. 2002 Aug 05; 196(3):303-10. PMID: 12163559; PMCID: PMC2193935.
    Citations: 130     Fields:    Translation:AnimalsCells
  112. Claypool SM, Dickinson BL, Yoshida M, Lencer WI, Blumberg RS. Functional reconstitution of human FcRn in Madin-Darby canine kidney cells requires co-expressed human beta 2-microglobulin. J Biol Chem. 2002 Aug 02; 277(31):28038-50. PMID: 12023961.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  113. Yue G, Merlin D, Selsted ME, Lencer WI, Madara JL, Eaton DC. Cryptdin 3 forms anion selective channels in cytoplasmic membranes of human embryonic kidney cells. Am J Physiol Gastrointest Liver Physiol. 2002 May; 282(5):G757-65. PMID: 11960772.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  114. Wolf AA, Fujinaga Y, Lencer WI. Uncoupling of the cholera toxin-G(M1) ganglioside receptor complex from endocytosis, retrograde Golgi trafficking, and downstream signal transduction by depletion of membrane cholesterol. J Biol Chem. 2002 May 03; 277(18):16249-56. PMID: 11859071.
    Citations: 37     Fields:    Translation:HumansCells
  115. Lencer WI, Barrett K, Colgan S, Cohen MB, Duggan CP, Kotelchuck M, Rhoads JM. Research agenda for pediatric gastroenterology, hepatology and nutrition: secretion and diarrhea. Report of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition for the Children's Digestive Health and Nutrition Foundation. J Pediatr Gastroenterol Nutr. 2002; 35 Suppl 3:S246-9. PMID: 12394359.
    Citations:    Fields:    Translation:Humans
  116. Wimer-Mackin S, Holmes RK, Wolf AA, Lencer WI, Jobling MG. Characterization of receptor-mediated signal transduction by Escherichia coli type IIa heat-labile enterotoxin in the polarized human intestinal cell line T84. Infect Immun. 2001 Dec; 69(12):7205-12. PMID: 11705889.
    Citations: 5     Fields:    Translation:HumansCells
  117. Fullner KJ, Lencer WI, Mekalanos JJ. Vibrio cholerae-induced cellular responses of polarized T84 intestinal epithelial cells are dependent on production of cholera toxin and the RTX toxin. Infect Immun. 2001 Oct; 69(10):6310-7. PMID: 11553575; PMCID: PMC98766.
    Citations: 21     Fields:    Translation:HumansCells
  118. Rodighiero C, Fujinaga Y, Hirst TR, Lencer WI. A cholera toxin B-subunit variant that binds ganglioside G(M1) but fails to induce toxicity. J Biol Chem. 2001 Oct 05; 276(40):36939-45. PMID: 11479294.
    Citations: 17     Fields:    Translation:HumansCells
  119. Aman AT, Fraser S, Merritt EA, Rodigherio C, Kenny M, Ahn M, Hol WG, Williams NA, Lencer WI, Hirst TR. A mutant cholera toxin B subunit that binds GM1- ganglioside but lacks immunomodulatory or toxic activity. Proc Natl Acad Sci U S A. 2001 Jul 17; 98(15):8536-41. PMID: 11447291; PMCID: PMC37471.
    Citations: 37     Fields:    Translation:AnimalsCells
  120. Blumberg RS, van de Wal Y, Claypool S, Corazza N, Dickinson B, Nieuwenhuis E, Pitman R, Spiekermann G, Zhu X, Colgan S, Lencer WI. The multiple roles of major histocompatibility complex class-I-like molecules in mucosal immune function. Acta Odontol Scand. 2001 Jun; 59(3):139-44. PMID: 11501882; PMCID: PMC2824335.
    Citations: 5     Fields:    Translation:HumansCells
  121. Lencer WI. Microbes and microbial Toxins: paradigms for microbial-mucosal toxins. V. Cholera: invasion of the intestinal epithelial barrier by a stably folded protein toxin. Am J Physiol Gastrointest Liver Physiol. 2001 May; 280(5):G781-6. PMID: 11292584.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  122. Tsai B, Rodighiero C, Lencer WI, Rapoport TA. Protein disulfide isomerase acts as a redox-dependent chaperone to unfold cholera toxin. Cell. 2001 Mar 23; 104(6):937-48. PMID: 11290330.
    Citations: 185     Fields:    Translation:AnimalsCells
  123. Zhu X, Meng G, Dickinson BL, Li X, Mizoguchi E, Miao L, Wang Y, Robert C, Wu B, Smith PD, Lencer WI, Blumberg RS. MHC class I-related neonatal Fc receptor for IgG is functionally expressed in monocytes, intestinal macrophages, and dendritic cells. J Immunol. 2001 Mar 01; 166(5):3266-76. PMID: 11207281; PMCID: PMC2827247.
    Citations: 121     Fields:    Translation:HumansCells
  124. Merlin D, Yue G, Lencer WI, Selsted ME, Madara JL. Cryptdin-3 induces novel apical conductance(s) in Cl- secretory, including cystic fibrosis, epithelia. Am J Physiol Cell Physiol. 2001 Feb; 280(2):C296-302. PMID: 11208524.
    Citations: 4     Fields:    Translation:HumansCells
  125. Lencer WI. Microbial invasion across the intestinal epithelial barrier. Pediatr Res. 2001 Jan; 49(1):4-5. PMID: 11134482.
    Citations: 1     Fields:    Translation:HumansCells
  126. Mel SF, Fullner KJ, Wimer-Mackin S, Lencer WI, Mekalanos JJ. Association of protease activity in Vibrio cholerae vaccine strains with decreases in transcellular epithelial resistance of polarized T84 intestinal epithelial cells. Infect Immun. 2000 Nov; 68(11):6487-92. PMID: 11035765.
    Citations: 34     Fields:    Translation:Cells
  127. Badizadegan K, Wolf AA, Rodighiero C, Jobling M, Hirst TR, Holmes RK, Lencer WI. Floating cholera toxin into epithelial cells: functional association with caveolae-like detergent-insoluble membrane microdomains. Int J Med Microbiol. 2000 Oct; 290(4-5):403-8. PMID: 11111918.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  128. Badizadegan K, Dickinson BL, Wheeler HE, Blumberg RS, Holmes RK, Lencer WI. Heterogeneity of detergent-insoluble membranes from human intestine containing caveolin-1 and ganglioside G(M1). Am J Physiol Gastrointest Liver Physiol. 2000 Jun; 278(6):G895-904. PMID: 10859219.
    Citations: 12     Fields:    Translation:Humans
  129. Lencer WI, Neutra MR. Salmonella pathogenesis: the trojan horse or the New York shuttle? Gastroenterology. 2000 Apr; 118(4):803-5. PMID: 10734034.
    Citations: 1     Fields:    Translation:HumansCells
  130. Dickinson BL, Badizadegan K, Wu Z, Ahouse JC, Zhu X, Simister NE, Blumberg RS, Lencer WI. Bidirectional FcRn-dependent IgG transport in a polarized human intestinal epithelial cell line. J Clin Invest. 1999 Oct; 104(7):903-11. PMID: 10510331; PMCID: PMC408555.
    Citations: 166     Fields:    Translation:HumansAnimalsCells
  131. Lencer WI. Floating the molecular machinery for t-cell activation. Gastroenterology. 1999 Aug; 117(2):503-5. PMID: 10419936.
    Citations:    Fields:    Translation:HumansCells
  132. Lencer WI, Hirst TR, Holmes RK. Membrane traffic and the cellular uptake of cholera toxin. Biochim Biophys Acta. 1999 Jul 08; 1450(3):177-90. PMID: 10395933.
    Citations: 76     Fields:    Translation:HumansCells
  133. Blumberg RS, Lencer WI, Zhu X, Kim HS, Claypool S, Balk SP, Saubermann LJ, Colgan SP. Antigen presentation by intestinal epithelial cells. Immunol Lett. 1999 Jun 15; 69(1):7-11. PMID: 10436875.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  134. Beauregard KE, Wimer-Mackin S, Collier RJ, Lencer WI. Anthrax toxin entry into polarized epithelial cells. Infect Immun. 1999 Jun; 67(6):3026-30. PMID: 10338515; PMCID: PMC96616.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  135. Rodighiero C, Aman AT, Kenny MJ, Moss J, Lencer WI, Hirst TR. Structural basis for the differential toxicity of cholera toxin and Escherichia coli heat-labile enterotoxin. Construction of hybrid toxins identifies the A2-domain as the determinant of differential toxicity. J Biol Chem. 1999 Feb 12; 274(7):3962-9. PMID: 9933586.
    Citations: 19     Fields:    Translation:HumansCells
  136. Lencer WI. Mucosal vaccination: "all politics are local". Gastroenterology. 1999 Feb; 116(2):497-9. PMID: 9922336.
    Citations: 1     Fields:    Translation:HumansCells
  137. Lencer WI, Alper SL. The potassium channel and how it works. Gastroenterology. 1999 Jan; 116(1):216-7. PMID: 9869622.
    Citations:    Fields:    Translation:HumansAnimalsCells
  138. Rodighiero C, Aman AT, Lencer WI, Hirst TR. Differential activity of cholera toxin and E. coli enterotoxin: construction and purification of mutant and hybrid derivatives. Biochem Soc Trans. 1998 Nov; 26(4):S364. PMID: 10047878.
    Citations: 1     Fields:    
  139. Merlin D, Jiang L, Strohmeier GR, Nusrat A, Alper SL, Lencer WI, Madara JL. Distinct Ca2+- and cAMP-dependent anion conductances in the apical membrane of polarized T84 cells. Am J Physiol. 1998 08; 275(2):C484-95. PMID: 9688603.
    Citations: 15     Fields:    Translation:HumansCells
  140. Lencer WI. Paneth cells: on the front line or in the backfield? Gastroenterology. 1998 Jun; 114(6):1343-5. PMID: 9618656.
    Citations:    Fields:    Translation:AnimalsCells
  141. Wolf AA, Jobling MG, Wimer-Mackin S, Ferguson-Maltzman M, Madara JL, Holmes RK, Lencer WI. Ganglioside structure dictates signal transduction by cholera toxin and association with caveolae-like membrane domains in polarized epithelia. J Cell Biol. 1998 May 18; 141(4):917-27. PMID: 9585411.
    Citations: 58     Fields:    Translation:HumansAnimalsCells
  142. Lencer WI. Acid secretion, ulcer disease, and cell biology. Gastroenterology. 1998 Mar; 114(3):607-8. PMID: 9496955.
    Citations:    Fields:    Translation:Animals
  143. Rufo PA, Merlin D, Riegler M, Ferguson-Maltzman MH, Dickinson BL, Brugnara C, Alper SL, Lencer WI. The antifungal antibiotic, clotrimazole, inhibits chloride secretion by human intestinal T84 cells via blockade of distinct basolateral K+ conductances. Demonstration of efficacy in intact rabbit colon and in an in vivo mouse model of cholera. J Clin Invest. 1997 Dec 15; 100(12):3111-20. PMID: 9399958; PMCID: PMC508524.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  144. Lencer WI, Cheung G, Strohmeier GR, Currie MG, Ouellette AJ, Selsted ME, Madara JL. Induction of epithelial chloride secretion by channel-forming cryptdins 2 and 3. Proc Natl Acad Sci U S A. 1997 Aug 05; 94(16):8585-9. PMID: 9238020; PMCID: PMC23028.
    Citations: 22     Fields:    Translation:HumansCells
  145. Lencer WI, Constable C, Moe S, Rufo PA, Wolf A, Jobling MG, Ruston SP, Madara JL, Holmes RK, Hirst TR. Proteolytic activation of cholera toxin and Escherichia coli labile toxin by entry into host epithelial cells. Signal transduction by a protease-resistant toxin variant. J Biol Chem. 1997 Jun 13; 272(24):15562-8. PMID: 9182593.
    Citations: 27     Fields:    Translation:HumansCells
  146. Strohmeier GR, Lencer WI, Patapoff TW, Thompson LF, Carlson SL, Moe SJ, Carnes DK, Mrsny RJ, Madara JL. Surface expression, polarization, and functional significance of CD73 in human intestinal epithelia. J Clin Invest. 1997 Jun 01; 99(11):2588-601. PMID: 9169488; PMCID: PMC508104.
    Citations: 75     Fields:    Translation:HumansCells
  147. Rufo PA, Jiang L, Moe SJ, Brugnara C, Alper SL, Lencer WI. The antifungal antibiotic, clotrimazole, inhibits Cl- secretion by polarized monolayers of human colonic epithelial cells. J Clin Invest. 1996 Nov 01; 98(9):2066-75. PMID: 8903326; PMCID: PMC507651.
    Citations: 19     Fields:    Translation:HumansCells
  148. Frey A, Giannasca KT, Weltzin R, Giannasca PJ, Reggio H, Lencer WI, Neutra MR. Role of the glycocalyx in regulating access of microparticles to apical plasma membranes of intestinal epithelial cells: implications for microbial attachment and oral vaccine targeting. J Exp Med. 1996 Sep 01; 184(3):1045-59. PMID: 9064322; PMCID: PMC2192803.
    Citations: 100     Fields:    Translation:HumansAnimalsCells
  149. Turner JR, Lencer WI, Carlson S, Madara JL. Carboxy-terminal vesicular stomatitis virus G protein-tagged intestinal Na+-dependent glucose cotransporter (SGLT1): maintenance of surface expression and global transport function with selective perturbation of transport kinetics and polarized expression. J Biol Chem. 1996 Mar 29; 271(13):7738-44. PMID: 8631815.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  150. Lencer WI, Constable C, Moe S, Jobling MG, Webb HM, Ruston S, Madara JL, Hirst TR, Holmes RK. Targeting of cholera toxin and Escherichia coli heat labile toxin in polarized epithelia: role of COOH-terminal KDEL. J Cell Biol. 1995 Nov; 131(4):951-62. PMID: 7490296.
    Citations: 69     Fields:    Translation:HumansCells
  151. Lencer WI, Moe S, Rufo PA, Madara JL. Transcytosis of cholera toxin subunits across model human intestinal epithelia. Proc Natl Acad Sci U S A. 1995 Oct 24; 92(22):10094-8. PMID: 7479732; PMCID: PMC40742.
    Citations: 39     Fields:    Translation:HumansCells
  152. Lencer WI, Strohmeier G, Moe S, Carlson SL, Constable CT, Madara JL. Signal transduction by cholera toxin: processing in vesicular compartments does not require acidification. Am J Physiol. 1995 Oct; 269(4 Pt 1):G548-57. PMID: 7485507.
    Citations: 21     Fields:    Translation:HumansCells
  153. Strohmeier GR, Reppert SM, Lencer WI, Madara JL. The A2b adenosine receptor mediates cAMP responses to adenosine receptor agonists in human intestinal epithelia. J Biol Chem. 1995 Feb 03; 270(5):2387-94. PMID: 7836474.
    Citations: 78     Fields:    Translation:HumansCells
  154. Hirst TR, Nashar TO, Eaglestone S, Lencer WI, Webb HM, Yu J. Bacterial and host interactions during the biogenesis, toxicity and immunogenicity of Escherichia coli heat-labile enterotoxin. Biochem Soc Trans. 1994 May; 22(2):306-9. PMID: 7958313.
    Citations: 2     Fields:    Translation:Cells
  155. Dosanjh A, Lencer W, Brown D, Ausiello DA, Stow JL. Heterologous expression of delta F508 CFTR results in decreased sialylation of membrane glycoconjugates. Am J Physiol. 1994 Feb; 266(2 Pt 1):C360-6. PMID: 7511336.
    Citations: 14     Fields:    Translation:AnimalsCells
  156. Lencer WI, de Almeida JB, Moe S, Stow JL, Ausiello DA, Madara JL. Entry of cholera toxin into polarized human intestinal epithelial cells. Identification of an early brefeldin A sensitive event required for A1-peptide generation. J Clin Invest. 1993 Dec; 92(6):2941-51. PMID: 8254049; PMCID: PMC288498.
    Citations: 48     Fields:    Translation:HumansCells
  157. Apter FM, Lencer WI, Finkelstein RA, Mekalanos JJ, Neutra MR. Monoclonal immunoglobulin A antibodies directed against cholera toxin prevent the toxin-induced chloride secretory response and block toxin binding to intestinal epithelial cells in vitro. Infect Immun. 1993 Dec; 61(12):5271-8. PMID: 7693598.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  158. Madara JL, Parkos C, Colgan S, MacLeod RJ, Nash S, Matthews J, Delp C, Lencer W. Cl- secretion in a model intestinal epithelium induced by a neutrophil-derived secretagogue. J Clin Invest. 1992 Jun; 89(6):1938-44. PMID: 1602001; PMCID: PMC295894.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  159. Lencer WI, Delp C, Neutra MR, Madara JL. Mechanism of cholera toxin action on a polarized human intestinal epithelial cell line: role of vesicular traffic. J Cell Biol. 1992 Jun; 117(6):1197-1209. PMID: 1318883; PMCID: PMC2289494.
    Citations: 65     Fields:    Translation:HumansCells
  160. Lencer WI, Brown D, Ausiello DA, Verkman AS. Endocytosis of water channels in rat kidney: cell specificity and correlation with in vivo antidiuresis. Am J Physiol. 1990 Dec; 259(6 Pt 1):C920-32. PMID: 1701969.
    Citations: 8     Fields:    Translation:AnimalsCells
  161. Lencer WI, Verkman AS, Arnaout MA, Ausiello DA, Brown D. Endocytic vesicles from renal papilla which retrieve the vasopressin-sensitive water channel do not contain a functional H+ ATPase. J Cell Biol. 1990 Aug; 111(2):379-89. PMID: 1696262; PMCID: PMC2116183.
    Citations: 14     Fields:    Translation:AnimalsCells
  162. Shi LB, Ye RG, Lencer WI, Verkman AS. [Characterization of proton pump and osmotic water transport in endocytic vesicles from rat kidney proximal tubule]. Sheng Li Xue Bao. 1990 Apr; 42(2):105-13. PMID: 2142810.
    Citations:    Fields:    Translation:Animals
  163. Lencer WI, Weyer P, Verkman AS, Ausiello DA, Brown D. FITC-dextran as a probe for endosome function and localization in kidney. Am J Physiol. 1990 Feb; 258(2 Pt 1):C309-17. PMID: 1689545.
    Citations: 29     Fields:    Translation:AnimalsCells
  164. Lencer WI, Reinhart FD, Neutra MR. Interaction of cholera toxin with cloned human goblet cells in monolayer culture. Am J Physiol. 1990 Jan; 258(1 Pt 1):G96-102. PMID: 2154122.
    Citations: 16     Fields:    Translation:HumansCells
  165. Ye RG, Shi LB, Lencer WI, Verkman AS. Functional colocalization of water channels and proton pumps in endosomes from kidney proximal tubule. J Gen Physiol. 1989 May; 93(5):885-902. PMID: 2472463; PMCID: PMC2216239.
    Citations: 12     Fields:    Translation:AnimalsCells
  166. Verkman AS, Lencer WI, Brown D, Ausiello DA. Endosomes from kidney collecting tubule cells contain the vasopressin-sensitive water channel. Nature. 1988 May 19; 333(6170):268-9. PMID: 3368004.
    Citations: 38     Fields:    Translation:AnimalsCells
  167. Lencer WI, Chu SH, Walker WA. Differential binding kinetics of cholera toxin to intestinal microvillus membrane during development. Infect Immun. 1987 Dec; 55(12):3126-30. PMID: 3679546.
    Citations: 15     Fields:    Translation:AnimalsCells
  168. Rubin S, Salomon M, Walleigh L, Lencer W, Bauchner H, Shalen W, Klein K, Summergrad P. Unionization of house staff. N Engl J Med. 1979 Nov 08; 301(19):1068. PMID: 492249.
    Citations:    Fields:    
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.