Harvard Catalyst Profiles

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Stuart K. Calderwood, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01CA176326 (CALDERWOOD, STUART KEITH) Mar 1, 2014 - Feb 28, 2019
    Complex Role of HSF1 in Breast Cancer
    Role: Principal Investigator
  2. R01CA119045 (CALDERWOOD, STUART KEITH) Dec 1, 2005 - Jun 30, 2017
    Extracellular Hsp70 and hyperthermia in tumor therapy
    Role: Principal Investigator
  3. R01CA094397 (CALDERWOOD, STUART KEITH) Aug 30, 2002 - Nov 30, 2007
    Gene Repression by HSF1 during hyperthermia and stresses
    Role: Principal Investigator
  4. R13CA086965 (CALDERWOOD, STUART K) Jul 10, 2000 - Jun 30, 2001
    Role: Principal Investigator
  5. R01CA083890 (CALDERWOOD, STUART K) Feb 15, 2000 - Dec 31, 2003
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Prince TL, Lang BJ, Guerrero-Gimenez ME, Fernandez-Muñoz JM, Ackerman A, Calderwood SK. HSF1: Primary Factor in Molecular Chaperone Expression and a Major Contributor to Cancer Morbidity. Cells. 2020 Apr 22; 9(4). PMID: 32331382.
  2. Okusha Y, Eguchi T, Tran MT, Sogawa C, Yoshida K, Itagaki M, Taha EA, Ono K, Aoyama E, Okamura H, Kozaki KI, Calderwood SK, Takigawa M, Okamoto K. Extracellular Vesicles Enriched with Moonlighting Metalloproteinase Are Highly Transmissive, Pro-Tumorigenic, and Trans-Activates Cellular Communication Network Factor (CCN2/CTGF): CRISPR against Cancer. Cancers (Basel). 2020 Apr 04; 12(4). PMID: 32260433.
  3. Eguchi T, Sogawa C, Ono K, Matsumoto M, Tran MT, Okusha Y, Lang BJ, Okamoto K, Calderwood SK. Cell Stress Induced Stressome Release Including Damaged Membrane Vesicles and Extracellular HSP90 by Prostate Cancer Cells. Cells. 2020 Mar 19; 9(3). PMID: 32204513.
  4. Rigo MM, Borges TJ, Lang BJ, Murshid A, Wolfgeher D, Calderwood SK, Truman AW, Bonorino C. Host expression system modulates recombinant Hsp70 activity through post-translational modifications. FEBS J. 2020 Mar 06. PMID: 32144867.
  5. Eguchi T, Taha EA, Calderwood SK, Ono K. A Novel Model of Cancer Drug Resistance: Oncosomal Release of Cytotoxic and Antibody-Based Drugs. Biology (Basel). 2020 Mar 05; 9(3). PMID: 32150875.
  6. Sogawa C, Eguchi T, Tran MT, Ishige M, Trin K, Okusha Y, Taha EA, Lu Y, Kawai H, Sogawa N, Takigawa M, Calderwood SK, Okamoto K, Kozaki KI. Antiparkinson Drug Benztropine Suppresses Tumor Growth, Circulating Tumor Cells, and Metastasis by Acting on SLC6A3/DAT and Reducing STAT3. Cancers (Basel). 2020 Feb 24; 12(2). PMID: 32102440.
  7. Murshid A, Borges TJ, Bonorino C, Lang BJ, Calderwood SK. Immunological Outcomes Mediated Upon Binding of Heat Shock Proteins to Scavenger Receptors SCARF1 and LOX-1, and Endocytosis by Mononuclear Phagocytes. Front Immunol. 2019; 10:3035. PMID: 31998315.
  8. Lang BJ, Guerrero-Giménez ME, Prince TL, Ackerman A, Bonorino C, Calderwood SK. Heat Shock Proteins Are Essential Components in Transformation and Tumor Progression: Cancer Cell Intrinsic Pathways and Beyond. Int J Mol Sci. 2019 Sep 11; 20(18). PMID: 31514477.
  9. Eguchi T, Prince TL, Tran MT, Sogawa C, Lang BJ, Calderwood SK. MZF1 and SCAND1 Reciprocally Regulate CDC37 Gene Expression in Prostate Cancer. Cancers (Basel). 2019 Jun 08; 11(6). PMID: 31181782.
  10. Calderwood SK, Repasky EA, Neckers L, Hightower LE. The IXth CSSI international symposium on heat shock proteins in biology and medicine: stress responses in health and disease : Alexandria Old Town, Alexandria, Virginia, November 10-13, 2018. Cell Stress Chaperones. 2019 01; 24(1):1-6. PMID: 30645757.
    Citations:    Fields:    
  11. Namba Y, Sogawa C, Okusha Y, Kawai H, Itagaki M, Ono K, Murakami J, Aoyama E, Ohyama K, Asaumi JI, Takigawa M, Okamoto K, Calderwood SK, Kozaki KI, Eguchi T. Depletion of Lipid Efflux Pump ABCG1 Triggers the Intracellular Accumulation of Extracellular Vesicles and Reduces Aggregation and Tumorigenesis of Metastatic Cancer Cells. Front Oncol. 2018; 8:376. PMID: 30364132.
  12. Fujiwara T, Eguchi T, Sogawa C, Ono K, Murakami J, Ibaragi S, Asaumi JI, Calderwood SK, Okamoto K, Kozaki KI. Carcinogenic epithelial-mesenchymal transition initiated by oral cancer exosomes is inhibited by anti-EGFR antibody cetuximab. Oral Oncol. 2018 11; 86:251-257. PMID: 30409309.
    Citations:    Fields:    
  13. Borges TJ, Murakami N, Machado FD, Murshid A, Lang BJ, Lopes RL, Bellan LM, Uehara M, Antunes KH, Pérez-Saéz MJ, Birrane G, Vianna P, Gonçalves JIB, Zanin RF, Azzi J, Abdi R, Ishido S, Shin JS, Souza APD, Calderwood SK, Riella LV, Bonorino C. March1-dependent modulation of donor MHC II on CD103+ dendritic cells mitigates alloimmunity. Nat Commun. 2018 08 28; 9(1):3482. PMID: 30154416.
    Citations:    Fields:    Translation:AnimalsCells
  14. Fujiwara T, Eguchi T, Sogawa C, Ono K, Murakami J, Ibaragi S, Asaumi JI, Okamoto K, Calderwood SK, Kozaki KI. Anti-EGFR antibody cetuximab is secreted by oral squamous cell carcinoma and alters EGF-driven mesenchymal transition. Biochem Biophys Res Commun. 2018 09 10; 503(3):1267-1272. PMID: 30017201.
    Citations: 1     Fields:    
  15. Gong J, Lang BJ, Weng D, Eguchi T, Murshid A, Borges TJ, Doshi S, Song B, Stevenson MA, Calderwood SK. Genotoxic stress induces Sca-1-expressing metastatic mammary cancer cells. Mol Oncol. 2018 08; 12(8):1249-1263. PMID: 29738110.
    Citations:    Fields:    
  16. Ono K, Eguchi T, Sogawa C, Calderwood SK, Futagawa J, Kasai T, Seno M, Okamoto K, Sasaki A, Kozaki KI. HSP-enriched properties of extracellular vesicles involve survival of metastatic oral cancer cells. J Cell Biochem. 2018 09; 119(9):7350-7362. PMID: 29768689.
    Citations: 1     Fields:    
  17. Kijima T, Prince TL, Tigue ML, Yim KH, Schwartz H, Beebe K, Lee S, Budzynski MA, Williams H, Trepel JB, Sistonen L, Calderwood S, Neckers L. HSP90 inhibitors disrupt a transient HSP90-HSF1 interaction and identify a noncanonical model of HSP90-mediated HSF1 regulation. Sci Rep. 2018 05 03; 8(1):6976. PMID: 29725069.
    Citations: 1     Fields:    
  18. Eguchi T, Sogawa C, Okusha Y, Uchibe K, Iinuma R, Ono K, Nakano K, Murakami J, Itoh M, Arai K, Fujiwara T, Namba Y, Murata Y, Ohyama K, Shimomura M, Okamura H, Takigawa M, Nakatsura T, Kozaki KI, Okamoto K, Calderwood SK. Organoids with cancer stem cell-like properties secrete exosomes and HSP90 in a 3D nanoenvironment. PLoS One. 2018; 13(2):e0191109. PMID: 29415026.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  19. Calderwood SK. Heat shock proteins and cancer: intracellular chaperones or extracellular signalling ligands? Philos Trans R Soc Lond B Biol Sci. 2018 Jan 19; 373(1738). PMID: 29203709.
    Citations: 4     Fields:    Translation:Cells
  20. Weng D, Calderwood SK, Gong J. A Novel Heat Shock Protein 70-based Vaccine Prepared from DC-Tumor Fusion Cells. Methods Mol Biol. 2018; 1709:359-369. PMID: 29177672.
    Citations:    Fields:    Translation:HumansCells
  21. Lang BJ, Holton KM, Gong J, Calderwood SK. A Workflow Guide to RNA-seq Analysis of Chaperone Function and Beyond. Methods Mol Biol. 2018; 1709:233-252. PMID: 29177664.
    Citations:    Fields:    Translation:HumansAnimalsCells
  22. Murshid A, Theriault J, Gong J, Calderwood SK. Molecular Chaperone Receptors. Methods Mol Biol. 2018; 1709:331-344. PMID: 29177670.
    Citations:    Fields:    Translation:HumansAnimalsCells
  23. Murshid A, Prince TL, Lang B, Calderwood SK. Role of Heat Shock Factors in Stress-Induced Transcription. Methods Mol Biol. 2018; 1709:23-34. PMID: 29177648.
    Citations:    Fields:    Translation:HumansAnimalsCells
  24. Calderwood SK, Murshid A. Molecular Chaperone Accumulation in Cancer and Decrease in Alzheimer's Disease: The Potential Roles of HSF1. Front Neurosci. 2017; 11:192. PMID: 28484363.
    Citations: 8     
  25. Calderwood SK, Murshid A, Borges TJ. Editorial: HSPs-Ambiguous Mediators of Immunity. Front Immunol. 2016; 7:639. PMID: 28082978.
  26. Snyder HM, Ahles T, Calderwood S, Carrillo MC, Chen H, Chang CH, Craft S, De Jager P, Driver JA, Fillit H, Knopman D, Lotze M, Tierney MC, Petanceska S, Saykin A, Seshadri S, Shineman D, Ganguli M. Exploring the nexus of Alzheimer's disease and related dementias with cancer and cancer therapies: A convening of the Alzheimer's Association & Alzheimer's Drug Discovery Foundation. Alzheimers Dement. 2017 Mar; 13(3):267-273. PMID: 27998721.
    Citations: 1     Fields:    Translation:Humans
  27. Arai K, Eguchi T, Rahman MM, Sakamoto R, Masuda N, Nakatsura T, Calderwood SK, Kozaki K, Itoh M. A Novel High-Throughput 3D Screening System for EMT Inhibitors: A Pilot Screening Discovered the EMT Inhibitory Activity of CDK2 Inhibitor SU9516. PLoS One. 2016; 11(9):e0162394. PMID: 27622654.
    Citations: 7     Fields:    Translation:HumansCells
  28. Murshid A, Borges TJ, Lang BJ, Calderwood SK. The Scavenger Receptor SREC-I Cooperates with Toll-Like Receptors to Trigger Inflammatory Innate Immune Responses. Front Immunol. 2016; 7:226. PMID: 27379091.
    Citations: 2     
  29. Eguchi T, Calderwood SK, Takigawa M, Kubota S, Kozaki KI. Intracellular MMP3 Promotes HSP Gene Expression in Collaboration With Chromobox Proteins. J Cell Biochem. 2017 01; 118(1):43-51. PMID: 27206651.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  30. Calderwood SK, Gong J, Murshid A. Extracellular HSPs: The Complicated Roles of Extracellular HSPs in Immunity. Front Immunol. 2016; 7:159. PMID: 27199984.
    Citations: 12     
  31. Calderwood SK. A critical role for topoisomerase IIb and DNA double strand breaks in transcription. Transcription. 2016 05 26; 7(3):75-83. PMID: 27100743.
    Citations: 5     Fields:    Translation:Cells
  32. Calderwood SK, Gong J. Heat Shock Proteins Promote Cancer: It's a Protection Racket. Trends Biochem Sci. 2016 04; 41(4):311-323. PMID: 26874923.
    Citations: 20     Fields:    Translation:HumansCells
  33. Calderwood SK. Creative damage unleashes transcription. Cell Cycle. 2016; 15(8):1021-2. PMID: 26919409.
    Citations:    Fields:    Translation:Cells
  34. Bunch H, Lawney BP, Lin YF, Asaithamby A, Murshid A, Wang YE, Chen BP, Calderwood SK. Transcriptional elongation requires DNA break-induced signalling. Nat Commun. 2015 Dec 16; 6:10191. PMID: 26671524.
    Citations: 21     Fields:    Translation:HumansCells
  35. Calderwood SK, Murshid A. Siglecs take a TOLL on inflammation: deciphering the Hsp70 riddle. EMBO J. 2015 Nov 12; 34(22):2733-4. PMID: 26474574.
    Citations: 1     Fields:    Translation:HumansCells
  36. Calderwood SK, Neckers L. Hsp90 in Cancer: Transcriptional Roles in the Nucleus. Adv Cancer Res. 2016; 129:89-106. PMID: 26916002.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  37. Eguchi T, Prince T, Wegiel B, Calderwood SK. Role and Regulation of Myeloid Zinc Finger Protein 1 in Cancer. J Cell Biochem. 2015 Oct; 116(10):2146-54. PMID: 25903835.
    Citations: 7     Fields:    Translation:HumansCells
  38. Bunch H, Calderwood SK. TRIM28 as a novel transcriptional elongation factor. BMC Mol Biol. 2015 Aug 21; 16:14. PMID: 26293668.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  39. Murshid A, Gong J, Prince T, Borges TJ, Calderwood SK. Scavenger receptor SREC-I mediated entry of TLR4 into lipid microdomains and triggered inflammatory cytokine release in RAW 264.7 cells upon LPS activation. PLoS One. 2015; 10(4):e0122529. PMID: 25836976.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  40. Murshid A, Borges TJ, Calderwood SK. Emerging roles for scavenger receptor SREC-I in immunity. Cytokine. 2015 Oct; 75(2):256-60. PMID: 25767073.
    Citations: 3     Fields:    Translation:HumansCells
  41. Gong J, Weng D, Eguchi T, Murshid A, Sherman MY, Song B, Calderwood SK. Targeting the hsp70 gene delays mammary tumor initiation and inhibits tumor cell metastasis. Oncogene. 2015 Oct; 34(43):5460-71. PMID: 25659585.
    Citations: 7     Fields:    Translation:AnimalsCells
  42. Calderwood SK. Cdc37 as a co-chaperone to Hsp90. Subcell Biochem. 2015; 78:103-12. PMID: 25487018.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  43. Murshid A, Gong J, Ahmad R, Borges TJ, Calderwood SK. Scavenger receptor SREC-I promotes double stranded RNA-mediated TLR3 activation in human monocytes. Immunobiology. 2015 Jun; 220(6):823-32. PMID: 25641411.
    Citations: 5     Fields:    Translation:HumansCells
  44. Calderwood SK, Hightower LE. Report on the VIIth International Symposium on Heat Shock Proteins in Biology & Medicine. Cell Stress Chaperones. 2015 Mar; 20(2):213-6. PMID: 25542250.
    Citations: 1     Fields:    Translation:HumansCells
  45. Amaral AC, Jakovcevski M, McGaughy JA, Calderwood SK, Mokler DJ, Rushmore RJ, Galler JR, Akbarian SA, Rosene DL. Prenatal protein malnutrition decreases KCNJ3 and 2DG activity in rat prefrontal cortex. Neuroscience. 2015 Feb 12; 286:79-86. PMID: 25446346.
    Citations: 2     Fields:    Translation:AnimalsCells
  46. Bunch H, Zheng X, Burkholder A, Dillon ST, Motola S, Birrane G, Ebmeier CC, Levine S, Fargo D, Hu G, Taatjes DJ, Calderwood SK. TRIM28 regulates RNA polymerase II promoter-proximal pausing and pause release. Nat Struct Mol Biol. 2014 Oct; 21(10):876-83. PMID: 25173174.
    Citations: 26     Fields:    Translation:HumansCells
  47. Murshid A, Gong J, Calderwood SK. Hsp90-peptide complexes stimulate antigen presentation through the class II pathway after binding scavenger receptor SREC-I. Immunobiology. 2014 Dec; 219(12):924-31. PMID: 25155057.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  48. Colvin TA, Gabai VL, Gong J, Calderwood SK, Li H, Gummuluru S, Matchuk ON, Smirnova SG, Orlova NV, Zamulaeva IA, Garcia-Marcos M, Li X, Young ZT, Rauch JN, Gestwicki JE, Takayama S, Sherman MY. Hsp70-Bag3 interactions regulate cancer-related signaling networks. Cancer Res. 2014 Sep 01; 74(17):4731-40. PMID: 24994713.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  49. Chou SD, Murshid A, Eguchi T, Gong J, Calderwood SK. HSF1 regulation of ß-catenin in mammary cancer cells through control of HuR/elavL1 expression. Oncogene. 2015 Apr 23; 34(17):2178-2188. PMID: 24954509.
    Citations: 20     Fields:    Translation:HumansCells
  50. Hara ES, Ono M, Eguchi T, Kubota S, Pham HT, Sonoyama W, Tajima S, Takigawa M, Calderwood SK, Kuboki T. miRNA-720 controls stem cell phenotype, proliferation and differentiation of human dental pulp cells. PLoS One. 2013; 8(12):e83545. PMID: 24386225.
    Citations: 20     Fields:    Translation:HumansCells
  51. Calderwood SK. From stress protein biochemistry to novel immunotherapeutics. Int J Hyperthermia. 2013 Aug; 29(5):362-3. PMID: 23902338.
    Citations:    Fields:    Translation:Humans
  52. Weng D, Song B, Koido S, Calderwood SK, Gong J. Immunotherapy of radioresistant mammary tumors with early metastasis using molecular chaperone vaccines combined with ionizing radiation. J Immunol. 2013 Jul 15; 191(2):755-63. PMID: 23772032.
    Citations: 14     Fields:    Translation:AnimalsCellsPHPublic Health
  53. Murshid A, Eguchi T, Calderwood SK. Stress proteins in aging and life span. Int J Hyperthermia. 2013 Aug; 29(5):442-7. PMID: 23742046.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  54. Calderwood SK, Gong J, Stevenson MA, Murshid A. Cellular and molecular chaperone fusion vaccines: targeting resistant cancer cell populations. Int J Hyperthermia. 2013 Aug; 29(5):376-9. PMID: 23682824.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  55. Calderwood SK. Molecular cochaperones: tumor growth and cancer treatment. Scientifica (Cairo). 2013; 2013:217513. PMID: 24278769.
    Citations: 14     
  56. Eguchi T, Watanabe K, Hara ES, Ono M, Kuboki T, Calderwood SK. OstemiR: a novel panel of microRNA biomarkers in osteoblastic and osteocytic differentiation from mesencymal stem cells. PLoS One. 2013; 8(3):e58796. PMID: 23533592.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  57. Calderwood SK. Tumor heterogeneity, clonal evolution, and therapy resistance: an opportunity for multitargeting therapy. Discov Med. 2013 Mar; 15(82):188-94. PMID: 23545047.
    Citations: 11     Fields:    Translation:HumansCells
  58. Murshid A, Gong J, Calderwood SK. Purification, preparation, and use of chaperone-peptide complexes for tumor immunotherapy. Methods Mol Biol. 2013; 960:209-217. PMID: 23329490.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  59. Calderwood SK. HSF1, a versatile factor in tumorogenesis. Curr Mol Med. 2012 Nov 01; 12(9):1102-7. PMID: 22804234.
    Citations: 14     Fields:    Translation:Humans
  60. Calderwood SK, Stevenson MA, Murshid A. Heat shock proteins, autoimmunity, and cancer treatment. Autoimmune Dis. 2012; 2012:486069. PMID: 23056925.
    Citations: 21     
  61. Ciocca DR, Arrigo AP, Calderwood SK. Heat shock proteins and heat shock factor 1 in carcinogenesis and tumor development: an update. Arch Toxicol. 2013 Jan; 87(1):19-48. PMID: 22885793.
    Citations: 75     Fields:    Translation:HumansCells
  62. Chou SD, Prince T, Gong J, Calderwood SK. mTOR is essential for the proteotoxic stress response, HSF1 activation and heat shock protein synthesis. PLoS One. 2012; 7(6):e39679. PMID: 22768106.
    Citations: 56     Fields:    Translation:HumansCells
  63. Calderwood SK, Murshid A, Gong J. Heat shock proteins: conditional mediators of inflammation in tumor immunity. Front Immunol. 2012; 3:75. PMID: 22566956.
    Citations: 13     
  64. Calderwood SK, Gong J. Molecular chaperones in mammary cancer growth and breast tumor therapy. J Cell Biochem. 2012 Apr; 113(4):1096-103. PMID: 22105880.
    Citations: 27     Fields:    Translation:HumansAnimals
  65. Calderwood SK. Elevated levels of HSF1 indicate a poor prognosis in breast cancer. Future Oncol. 2012 Apr; 8(4):399-401. PMID: 22515443.
    Citations: 3     Fields:    
  66. Murshid A, Gong J, Calderwood SK. The role of heat shock proteins in antigen cross presentation. Front Immunol. 2012; 3:63. PMID: 22566944.
    Citations: 39     
  67. Weng D, Penzner JH, Song B, Koido S, Calderwood SK, Gong J. Metastasis is an early event in mouse mammary carcinomas and is associated with cells bearing stem cell markers. Breast Cancer Res. 2012 Jan 25; 14(1):R18. PMID: 22277639.
    Citations: 26     Fields:    Translation:AnimalsCells
  68. Zhang Y, Murshid A, Prince T, Calderwood SK. Protein kinase A regulates molecular chaperone transcription and protein aggregation. PLoS One. 2011; 6(12):e28950. PMID: 22216146.
    Citations: 13     Fields:    Translation:AnimalsCells
  69. Ogawa K, Kim HK, Shimizu T, Abe S, Shiga Y, Calderwood SK. Plasma heat shock protein 72 as a biomarker of sarcopenia in elderly people. Cell Stress Chaperones. 2012 May; 17(3):349-59. PMID: 22144131.
    Citations: 8     Fields:    Translation:Humans
  70. Murshid A, Gong J, Stevenson MA, Calderwood SK. Heat shock proteins and cancer vaccines: developments in the past decade and chaperoning in the decade to come. Expert Rev Vaccines. 2011 Nov; 10(11):1553-68. PMID: 22043955.
    Citations: 28     Fields:    Translation:Humans
  71. Weng D, Song B, Durfee J, Sugiyama V, Wu Z, Koido S, Calderwood SK, Gong J. Induction of cytotoxic T lymphocytes against ovarian cancer-initiating cells. Int J Cancer. 2011 Oct 15; 129(8):1990-2001. PMID: 21154809.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  72. Zhang Y, Chou SD, Murshid A, Prince TL, Schreiner S, Stevenson MA, Calderwood SK. The role of heat shock factors in stress-induced transcription. Methods Mol Biol. 2011; 787:21-32. PMID: 21898224.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  73. Zhang Y, Calderwood SK. Autophagy, protein aggregation and hyperthermia: a mini-review. Int J Hyperthermia. 2011; 27(5):409-14. PMID: 21756038.
    Citations: 10     Fields:    Translation:HumansCells
  74. Ogawa K, Seta R, Shimizu T, Shinkai S, Calderwood SK, Nakazato K, Takahashi K. Plasma adenosine triphosphate and heat shock protein 72 concentrations after aerobic and eccentric exercise. Exerc Immunol Rev. 2011; 17:136-49. PMID: 21446356.
    Citations: 6     Fields:    Translation:Humans
  75. Weng D, Calderwood SK, Gong J. Preparation of a heat-shock protein 70-based vaccine from DC-tumor fusion cells. Methods Mol Biol. 2011; 787:255-65. PMID: 21898241.
    Citations: 4     Fields:    Translation:HumansCells
  76. Murshid A, Theriault J, Gong J, Calderwood SK. Investigating receptors for extracellular heat shock proteins. Methods Mol Biol. 2011; 787:289-302. PMID: 21898244.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  77. Murshid A, Chou SD, Prince T, Zhang Y, Bharti A, Calderwood SK. Protein kinase A binds and activates heat shock factor 1. PLoS One. 2010 Nov 09; 5(11):e13830. PMID: 21085490.
    Citations: 23     Fields:    Translation:HumansCells
  78. Weng D, Cunin MC, Song B, Price BD, Eller MS, Gilchrest BA, Calderwood SK, Gong J. Radiosensitization of mammary carcinoma cells by telomere homolog oligonucleotide pretreatment. Breast Cancer Res. 2010; 12(5):R71. PMID: 20846433.
    Citations: 5     Fields:    Translation:AnimalsCells
  79. Murshid A, Gong J, Calderwood SK. Heat shock protein 90 mediates efficient antigen cross presentation through the scavenger receptor expressed by endothelial cells-I. J Immunol. 2010 Sep 01; 185(5):2903-17. PMID: 20686127.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  80. Henderson B, Calderwood SK, Coates AR, Cohen I, van Eden W, Lehner T, Pockley AG. Caught with their PAMPs down? The extracellular signalling actions of molecular chaperones are not due to microbial contaminants. Cell Stress Chaperones. 2010 Mar; 15(2):123-41. PMID: 19731087.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  81. Calderwood SK. Heat shock proteins in breast cancer progression--a suitable case for treatment? Int J Hyperthermia. 2010; 26(7):681-5. PMID: 20653417.
    Citations: 24     Fields:    Translation:Humans
  82. Calderwood SK, Xie Y, Wang X, Khaleque MA, Chou SD, Murshid A, Prince T, Zhang Y. Signal Transduction Pathways Leading to Heat Shock Transcription. Sign Transduct Insights. 2010; 2:13-24. PMID: 21687820.
    Citations: 28     
  83. Gong J, Zhang Y, Durfee J, Weng D, Liu C, Koido S, Song B, Apostolopoulos V, Calderwood SK. A heat shock protein 70-based vaccine with enhanced immunogenicity for clinical use. J Immunol. 2010 Jan 01; 184(1):488-96. PMID: 19949080.
    Citations: 32     Fields:    Translation:HumansCells
  84. Adachi M, Liu Y, Fujii K, Calderwood SK, Nakai A, Imai K, Shinomura Y. Oxidative stress impairs the heat stress response and delays unfolded protein recovery. PLoS One. 2009 Nov 11; 4(11):e7719. PMID: 19936221.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  85. Kottke T, Pulido J, Thompson J, Sanchez-Perez L, Chong H, Calderwood SK, Selby P, Harrington K, Strome SE, Melcher A, Vile RG. Antitumor immunity can be uncoupled from autoimmunity following heat shock protein 70-mediated inflammatory killing of normal pancreas. Cancer Res. 2009 Oct 01; 69(19):7767-74. PMID: 19738045.
    Citations: 13     Fields:    Translation:AnimalsCells
  86. Jaskelioff M, Song W, Xia J, Liu C, Kramer J, Koido S, Gendler SJ, Calderwood SK, Gong J. Telomerase deficiency and telomere dysfunction inhibit mammary tumors induced by polyomavirus middle T oncogene. Oncogene. 2009 Dec 03; 28(48):4225-36. PMID: 19734944.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  87. Gong J, Zhu B, Murshid A, Adachi H, Song B, Lee A, Liu C, Calderwood SK. T cell activation by heat shock protein 70 vaccine requires TLR signaling and scavenger receptor expressed by endothelial cells-1. J Immunol. 2009 Sep 01; 183(5):3092-8. PMID: 19641135.
    Citations: 29     Fields:    Translation:AnimalsCells
  88. Calderwood SK, Murshid A, Prince T. The shock of aging: molecular chaperones and the heat shock response in longevity and aging--a mini-review. Gerontology. 2009; 55(5):550-8. PMID: 19546513.
    Citations: 96     Fields:    Translation:HumansAnimalsCells
  89. Li GC, Calderwood SK. Hyperthermia classic article commentary: 'Re-induction of hsp70 synthesis: an assay for thermotolerance' by Gloria C. Li and Johnson Y. Mak, International Journal of Hyperthermia 1989;5:389-403. Int J Hyperthermia. 2009 Jun; 25(4):258-61. PMID: 19670094.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  90. Pockley AG, Calderwood SK, Multhoff G. The atheroprotective properties of Hsp70: a role for Hsp70-endothelial interactions? Cell Stress Chaperones. 2009 Nov; 14(6):545-53. PMID: 19357992.
    Citations: 24     Fields:    Translation:HumansCells
  91. Gong J, Koido S, Calderwood SK. Cell fusion: from hybridoma to dendritic cell-based vaccine. Expert Rev Vaccines. 2008 Sep; 7(7):1055-68. PMID: 18767954.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  92. Murshid A, Gong J, Calderwood SK. Heat-shock proteins in cancer vaccines: agents of antigen cross-presentation. Expert Rev Vaccines. 2008 Sep; 7(7):1019-30. PMID: 18767951.
    Citations: 30     Fields:    Translation:HumansAnimals
  93. Gray PJ, Prince T, Cheng J, Stevenson MA, Calderwood SK. Targeting the oncogene and kinome chaperone CDC37. Nat Rev Cancer. 2008 07; 8(7):491-5. PMID: 18511936.
    Citations: 36     Fields:    Translation:Humans
  94. Calderwood SK, Ciocca DR. Heat shock proteins: stress proteins with Janus-like properties in cancer. Int J Hyperthermia. 2008 Feb; 24(1):31-9. PMID: 18214767.
    Citations: 47     Fields:    Translation:HumansCells
  95. Park MA, Yacoub A, Rahmani M, Zhang G, Hart L, Hagan MP, Calderwood SK, Sherman MY, Koumenis C, Spiegel S, Chen CS, Graf M, Curiel DT, Fisher PB, Grant S, Dent P. OSU-03012 stimulates PKR-like endoplasmic reticulum-dependent increases in 70-kDa heat shock protein expression, attenuating its lethal actions in transformed cells. Mol Pharmacol. 2008 Apr; 73(4):1168-84. PMID: 18182481.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  96. Pockley AG, Muthana M, Calderwood SK. The dual immunoregulatory roles of stress proteins. Trends Biochem Sci. 2008 Feb; 33(2):71-9. PMID: 18182297.
    Citations: 65     Fields:    Translation:AnimalsCells
  97. Calderwood SK, Gong J, Theriault JR, Mambula SS, Gray PJ. Cell stress proteins: novel immunotherapeutics. Novartis Found Symp. 2008; 291:115-31; discussion 131-40. PMID: 18575270.
    Citations: 6     Fields:    Translation:HumansCells
  98. Gray PJ, Stevenson MA, Calderwood SK. Targeting Cdc37 inhibits multiple signaling pathways and induces growth arrest in prostate cancer cells. Cancer Res. 2007 Dec 15; 67(24):11942-50. PMID: 18089825.
    Citations: 31     Fields:    Translation:HumansCells
  99. Kottke T, Sanchez-Perez L, Diaz RM, Thompson J, Chong H, Harrington K, Calderwood SK, Pulido J, Georgopoulos N, Selby P, Melcher A, Vile R. Induction of hsp70-mediated Th17 autoimmunity can be exploited as immunotherapy for metastatic prostate cancer. Cancer Res. 2007 Dec 15; 67(24):11970-9. PMID: 18089828.
    Citations: 31     Fields:    Translation:AnimalsCells
  100. Calderwood SK, Theriault J, Gray PJ, Gong J. Cell surface receptors for molecular chaperones. Methods. 2007 Nov; 43(3):199-206. PMID: 17920516.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  101. Mambula SS, Stevenson MA, Ogawa K, Calderwood SK. Mechanisms for Hsp70 secretion: crossing membranes without a leader. Methods. 2007 Nov; 43(3):168-75. PMID: 17920512.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  102. Calderwood SK. Heat shock proteins in extracellular signaling. Methods. 2007 Nov; 43(3):167. PMID: 24489453.
    Citations: 3     Fields:    
  103. Khaleque MA, Bharti A, Gong J, Gray PJ, Sachdev V, Ciocca DR, Stati A, Fanelli M, Calderwood SK. Heat shock factor 1 represses estrogen-dependent transcription through association with MTA1. Oncogene. 2008 Mar 20; 27(13):1886-93. PMID: 17922035.
    Citations: 46     Fields:    Translation:HumansCells
  104. Calderwood SK, Mambula SS, Gray PJ. Extracellular heat shock proteins in cell signaling and immunity. Ann N Y Acad Sci. 2007 Oct; 1113:28-39. PMID: 17978280.
    Citations: 74     Fields:    Translation:HumansAnimalsCells
  105. Tang D, Kang R, Xiao W, Wang H, Calderwood SK, Xiao X. The anti-inflammatory effects of heat shock protein 72 involve inhibition of high-mobility-group box 1 release and proinflammatory function in macrophages. J Immunol. 2007 Jul 15; 179(2):1236-44. PMID: 17617616.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  106. Calderwood SK, Mambula SS, Gray PJ, Theriault JR. Extracellular heat shock proteins in cell signaling. FEBS Lett. 2007 Jul 31; 581(19):3689-94. PMID: 17499247.
    Citations: 94     Fields:    Translation:HumansCells
  107. Asea AA, Milani V, Calderwood SK. Heat shock proteins in physiology and pathology: the Berlin meeting. Cell Stress Chaperones. 2007; 12(3):205-8. PMID: 17915552.
    Citations: 1     Fields:    Translation:HumansAnimals
  108. Thériault JR, Adachi H, Calderwood SK. Role of scavenger receptors in the binding and internalization of heat shock protein 70. J Immunol. 2006 Dec 15; 177(12):8604-11. PMID: 17142759.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  109. Mambula SS, Calderwood SK. Heat shock protein 70 is secreted from tumor cells by a nonclassical pathway involving lysosomal endosomes. J Immunol. 2006 Dec 01; 177(11):7849-57. PMID: 17114456.
    Citations: 94     Fields:    Translation:HumansCells
  110. Enomoto Y, Bharti A, Khaleque AA, Song B, Liu C, Apostolopoulos V, Xing PX, Calderwood SK, Gong J. Enhanced immunogenicity of heat shock protein 70 peptide complexes from dendritic cell-tumor fusion cells. J Immunol. 2006 Nov 01; 177(9):5946-55. PMID: 17056519.
    Citations: 35     Fields:    Translation:AnimalsCellsPHPublic Health
  111. Mambula SS, Calderwood SK. Heat induced release of Hsp70 from prostate carcinoma cells involves both active secretion and passive release from necrotic cells. Int J Hyperthermia. 2006 Nov; 22(7):575-85. PMID: 17079215.
    Citations: 23     Fields:    Translation:HumansCells
  112. Ciocca DR, Gago FE, Fanelli MA, Calderwood SK. Co-expression of steroid receptors (estrogen receptor alpha and/or progesterone receptors) and Her-2/neu: Clinical implications. J Steroid Biochem Mol Biol. 2006 Dec; 102(1-5):32-40. PMID: 17049840.
    Citations: 19     Fields:    Translation:Humans
  113. Shi Y, Tu Z, Tang D, Zhang H, Liu M, Wang K, Calderwood SK, Xiao X. The inhibition of LPS-induced production of inflammatory cytokines by HSP70 involves inactivation of the NF-kappaB pathway but not the MAPK pathways. Shock. 2006 Sep; 26(3):277-84. PMID: 16912653.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  114. Calderwood SK, Khaleque MA, Sawyer DB, Ciocca DR. Heat shock proteins in cancer: chaperones of tumorigenesis. Trends Biochem Sci. 2006 Mar; 31(3):164-72. PMID: 16483782.
    Citations: 250     Fields:    Translation:HumansAnimals
  115. Zaarur N, Gabai VL, Porco JA, Calderwood S, Sherman MY. Targeting heat shock response to sensitize cancer cells to proteasome and Hsp90 inhibitors. Cancer Res. 2006 Feb 01; 66(3):1783-91. PMID: 16452239.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  116. Calderwood SK, Theriault JR, Gong J. How is the immune response affected by hyperthermia and heat shock proteins? Int J Hyperthermia. 2005 Dec; 21(8):713-6. PMID: 16338853.
    Citations: 15     Fields:    Translation:HumansCells
  117. Wang X, Khaleque MA, Zhao MJ, Zhong R, Gaestel M, Calderwood SK. Phosphorylation of HSF1 by MAPK-activated protein kinase 2 on serine 121, inhibits transcriptional activity and promotes HSP90 binding. J Biol Chem. 2006 Jan 13; 281(2):782-91. PMID: 16278218.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  118. Khaleque MA, Bharti A, Sawyer D, Gong J, Benjamin IJ, Stevenson MA, Calderwood SK. Induction of heat shock proteins by heregulin beta1 leads to protection from apoptosis and anchorage-independent growth. Oncogene. 2005 Sep 29; 24(43):6564-73. PMID: 16007186.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
  119. Calderwood SK, Theriault JR, Gong J. Message in a bottle: role of the 70-kDa heat shock protein family in anti-tumor immunity. Eur J Immunol. 2005 Sep; 35(9):2518-27. PMID: 16144035.
    Citations: 47     Fields:    Translation:HumansAnimalsCells
  120. Calderwood SK. Evolving connections between molecular chaperones and neuronal function. Int J Hyperthermia. 2005 Aug; 21(5):375-8. PMID: 16048835.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  121. Tonkiss J, Calderwood SK. Regulation of heat shock gene transcription in neuronal cells. Int J Hyperthermia. 2005 Aug; 21(5):433-44. PMID: 16048840.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  122. Thériault JR, Mambula SS, Sawamura T, Stevenson MA, Calderwood SK. Extracellular HSP70 binding to surface receptors present on antigen presenting cells and endothelial/epithelial cells. FEBS Lett. 2005 Mar 28; 579(9):1951-60. PMID: 15792802.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  123. Calderwood SK. Chaperones and slow death--a recipe for tumor immunotherapy. Trends Biotechnol. 2005 Feb; 23(2):57-9. PMID: 15661338.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  124. Peng X, Guo X, Borkan SC, Bharti A, Kuramochi Y, Calderwood S, Sawyer DB. Heat shock protein 90 stabilization of ErbB2 expression is disrupted by ATP depletion in myocytes. J Biol Chem. 2005 Apr 01; 280(13):13148-52. PMID: 15671027.
    Citations: 27     Fields:    Translation:AnimalsCells
  125. Tang D, Khaleque MA, Jones EL, Theriault JR, Li C, Wong WH, Stevenson MA, Calderwood SK. Expression of heat shock proteins and heat shock protein messenger ribonucleic acid in human prostate carcinoma in vitro and in tumors in vivo. Cell Stress Chaperones. 2005; 10(1):46-58. PMID: 15832947.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  126. Ciocca DR, Calderwood SK. Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications. Cell Stress Chaperones. 2005; 10(2):86-103. PMID: 16038406.
    Citations: 348     Fields:    Translation:HumansAnimals
  127. Calderwood SK. Regulatory interfaces between the stress protein response and other gene expression programs in the cell. Methods. 2005 Feb; 35(2):139-48. PMID: 15649840.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  128. Jones EL, Zhao MJ, Stevenson MA, Calderwood SK. The 70 kilodalton heat shock protein is an inhibitor of apoptosis in prostate cancer. Int J Hyperthermia. 2004 Dec; 20(8):835-49. PMID: 15764345.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  129. Wang X, Grammatikakis N, Siganou A, Stevenson MA, Calderwood SK. Interactions between extracellular signal-regulated protein kinase 1, 14-3-3epsilon, and heat shock factor 1 during stress. J Biol Chem. 2004 Nov 19; 279(47):49460-9. PMID: 15364926.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  130. Tanaka Y, Koido S, Xia J, Ohana M, Liu C, Cote GM, Sawyer DB, Calderwood S, Gong J. Development of antigen-specific CD8+ CTL in MHC class I-deficient mice through CD4 to CD8 conversion. J Immunol. 2004 Jun 15; 172(12):7848-58. PMID: 15187169.
    Citations: 7     Fields:    Translation:AnimalsCellsPHPublic Health
  131. Wang Y, Theriault JR, He H, Gong J, Calderwood SK. Expression of a dominant negative heat shock factor-1 construct inhibits aneuploidy in prostate carcinoma cells. J Biol Chem. 2004 Jul 30; 279(31):32651-9. PMID: 15152009.
    Citations: 20     Fields:    Translation:HumansCells
  132. Wang X, Grammatikakis N, Siganou A, Calderwood SK. Regulation of molecular chaperone gene transcription involves the serine phosphorylation, 14-3-3 epsilon binding, and cytoplasmic sequestration of heat shock factor 1. Mol Cell Biol. 2003 Sep; 23(17):6013-26. PMID: 12917326.
    Citations: 28     Fields:    Translation:HumansCells
  133. He H, Soncin F, Grammatikakis N, Li Y, Siganou A, Gong J, Brown SA, Kingston RE, Calderwood SK. Elevated expression of heat shock factor (HSF) 2A stimulates HSF1-induced transcription during stress. J Biol Chem. 2003 Sep 12; 278(37):35465-75. PMID: 12813038.
    Citations: 28     Fields:    Translation:HumansCells
  134. Soncin F, Zhang X, Chu B, Wang X, Asea A, Ann Stevenson M, Sacks DB, Calderwood SK. Transcriptional activity and DNA binding of heat shock factor-1 involve phosphorylation on threonine 142 by CK2. Biochem Biophys Res Commun. 2003 Apr 04; 303(2):700-6. PMID: 12659875.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  135. Xie Y, Zhong R, Chen C, Calderwood SK. Heat shock factor 1 contains two functional domains that mediate transcriptional repression of the c-fos and c-fms genes. J Biol Chem. 2003 Feb 14; 278(7):4687-98. PMID: 12468538.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  136. Noessner E, Gastpar R, Milani V, Brandl A, Hutzler PJ, Kuppner MC, Roos M, Kremmer E, Asea A, Calderwood SK, Issels RD. Tumor-derived heat shock protein 70 peptide complexes are cross-presented by human dendritic cells. J Immunol. 2002 Nov 15; 169(10):5424-32. PMID: 12421917.
    Citations: 49     Fields:    Translation:HumansCells
  137. Calderwood SK, Asea A. Targeting HSP70-induced thermotolerance for design of thermal sensitizers. Int J Hyperthermia. 2002 Nov-Dec; 18(6):597-608. PMID: 12537758.
    Citations: 9     Fields:    Translation:HumansAnimals
  138. Zhao M, Tang D, Lechpammer S, Hoffman A, Asea A, Stevenson MA, Calderwood SK. Double-stranded RNA-dependent protein kinase (pkr) is essential for thermotolerance, accumulation of HSP70, and stabilization of ARE-containing HSP70 mRNA during stress. J Biol Chem. 2002 Nov 15; 277(46):44539-47. PMID: 12207033.
    Citations: 15     Fields:    Translation:AnimalsCells
  139. Lechpammer S, Asea A, Mallick R, Zhong R, Sherman MY, Calderwood SK. Development of an XTT tetrazolium salt-based assay for detection of specific hyperthermia sensitizers in a high-flux screening programme. Int J Hyperthermia. 2002 May-Jun; 18(3):203-15. PMID: 12061330.
    Citations: 3     Fields:    Translation:AnimalsCells
  140. Xie Y, Chen C, Stevenson MA, Hume DA, Auron PE, Calderwood SK. NF-IL6 and HSF1 have mutually antagonistic effects on transcription in monocytic cells. Biochem Biophys Res Commun. 2002 Mar 08; 291(4):1071-80. PMID: 11866474.
    Citations: 12     Fields:    Translation:AnimalsCells
  141. Asea A, Rehli M, Kabingu E, Boch JA, Bare O, Auron PE, Stevenson MA, Calderwood SK. Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4. J Biol Chem. 2002 Apr 26; 277(17):15028-34. PMID: 11836257.
    Citations: 366     Fields:    Translation:HumansCells
  142. Xie Y, Chen C, Stevenson MA, Auron PE, Calderwood SK. Heat shock factor 1 represses transcription of the IL-1beta gene through physical interaction with the nuclear factor of interleukin 6. J Biol Chem. 2002 Apr 05; 277(14):11802-10. PMID: 11801594.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
  143. Singh IS, He JR, Calderwood S, Hasday JD. A high affinity HSF-1 binding site in the 5'-untranslated region of the murine tumor necrosis factor-alpha gene is a transcriptional repressor. J Biol Chem. 2002 Feb 15; 277(7):4981-8. PMID: 11734555.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  144. Asea A, Mallick R, Lechpammer S, Ara G, Teicher BA, Fiorentino S, Stevenson MA, Calderwood SK. Cyclooxygenase inhibitors are potent sensitizers of prostate tumours to hyperthermia and radiation. Int J Hyperthermia. 2001 Sep-Oct; 17(5):401-14. PMID: 11587078.
    Citations: 3     Fields:    Translation:HumansAnimals
  145. Asea A, Ara G, Teicher BA, Stevenson MA, Calderwood SK. Effects of the flavonoid drug quercetin on the response of human prostate tumours to hyperthermia in vitro and in vivo. Int J Hyperthermia. 2001 Jul-Aug; 17(4):347-56. PMID: 11471985.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  146. Ehmann UK, Calderwood SK, Stevenson MA. Gap-junctional communication between feeder cells and recipient normal epithelial cells correlates with growth stimulation. In Vitro Cell Dev Biol Anim. 2001 Feb; 37(2):100-10. PMID: 11332735.
    Citations: 4     Fields:    Translation:AnimalsCells
  147. Tang D, Xie Y, Zhao M, Stevenson MA, Calderwood SK. Repression of the HSP70B promoter by NFIL6, Ku70, and MAPK involves three complementary mechanisms. Biochem Biophys Res Commun. 2001 Jan 12; 280(1):280-5. PMID: 11162511.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  148. Soncin F, Asea A, Zhang X, Stevenson MA, Calderwood SK. Role of calcium activated kinases and phosphatases in heat shock factor-1 activation. Int J Mol Med. 2000 Dec; 6(6):705-10. PMID: 11078832.
    Citations:    Fields:    Translation:HumansCells
  149. Asea A, Kabingu E, Stevenson MA, Calderwood SK. HSP70 peptidembearing and peptide-negative preparations act as chaperokines. Cell Stress Chaperones. 2000 Nov; 5(5):425-31. PMID: 11189447.
    Citations: 44     Fields:    Translation:AnimalsCells
  150. He H, Chen C, Xie Y, Asea A, Calderwood SK. HSP70 and heat shock factor 1 cooperate to repress Ras-induced transcriptional activation of the c-fos gene. Cell Stress Chaperones. 2000 Nov; 5(5):406-11. PMID: 11189444.
    Citations: 3     Fields:    Translation:AnimalsCells
  151. Wang X, Asea A, Xie Y, Kabingu E, Stevenson MA, Calderwood SK. RSK2 represses HSF1 activation during heat shock. Cell Stress Chaperones. 2000 Nov; 5(5):432-7. PMID: 11189448.
    Citations: 5     Fields:    Translation:HumansCells
  152. Hecker KH, Asea A, Kobayashi K, Green S, Tang D, Calderwood SK. Mutation detection in the human HSP7OB' gene by denaturing high-performance liquid chromatography. Cell Stress Chaperones. 2000 Nov; 5(5):415-24. PMID: 11189446.
    Citations: 1     Fields:    Translation:HumansCells
  153. Asea A, Kraeft SK, Kurt-Jones EA, Stevenson MA, Chen LB, Finberg RW, Koo GC, Calderwood SK. HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine. Nat Med. 2000 Apr; 6(4):435-42. PMID: 10742151.
    Citations: 357     Fields:    Translation:HumansCells
  154. Singh IS, Viscardi RM, Kalvakolanu I, Calderwood S, Hasday JD. Inhibition of tumor necrosis factor-alpha transcription in macrophages exposed to febrile range temperature. A possible role for heat shock factor-1 as a negative transcriptional regulator. J Biol Chem. 2000 Mar 31; 275(13):9841-8. PMID: 10734139.
    Citations: 35     Fields:    Translation:AnimalsCells
  155. Palayoor ST, Youmell MY, Calderwood SK, Coleman CN, Price BD. Constitutive activation of IkappaB kinase alpha and NF-kappaB in prostate cancer cells is inhibited by ibuprofen. Oncogene. 1999 Dec 02; 18(51):7389-94. PMID: 10602496.
    Citations: 67     Fields:    Translation:HumansCells
  156. Stevenson MA, Zhao MJ, Asea A, Coleman CN, Calderwood SK. Salicylic acid and aspirin inhibit the activity of RSK2 kinase and repress RSK2-dependent transcription of cyclic AMP response element binding protein- and NF-kappa B-responsive genes. J Immunol. 1999 Nov 15; 163(10):5608-16. PMID: 10553090.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  157. Housby JN, Cahill CM, Chu B, Prevelige R, Bickford K, Stevenson MA, Calderwood SK. Non-steroidal anti-inflammatory drugs inhibit the expression of cytokines and induce HSP70 in human monocytes. Cytokine. 1999 May; 11(5):347-58. PMID: 10328874.
    Citations: 24     Fields:    Translation:HumansCells
  158. Bruce JL, Chen C, Xie Y, Zhong R, Wang YQ, Stevenson MA, Calderwood SK. Activation of heat shock transcription factor 1 to a DNA binding form during the G(1)phase of the cell cycle. Cell Stress Chaperones. 1999 Mar; 4(1):36-45. PMID: 10467107.
    Citations: 5     Fields:    Translation:HumansCells
  159. Xie Y, Cahill CM, Asea A, Auron PE, Calderwood SK. Heat shock proteins and regulation of cytokine expression. Infect Dis Obstet Gynecol. 1999; 7(1-2):26-30. PMID: 10231005.
    Citations: 7     Fields:    Translation:HumansCells
  160. Ehmann UK, Stevenson MA, Calderwood SK, DeVries JT. Physical connections between feeder cells and recipient normal mammary epithelial cells. Exp Cell Res. 1998 Aug 25; 243(1):76-86. PMID: 9716451.
    Citations: 3     Fields:    Translation:AnimalsCells
  161. Chu B, Zhong R, Soncin F, Stevenson MA, Calderwood SK. Transcriptional activity of heat shock factor 1 at 37 degrees C is repressed through phosphorylation on two distinct serine residues by glycogen synthase kinase 3 and protein kinases Calpha and Czeta. J Biol Chem. 1998 Jul 17; 273(29):18640-6. PMID: 9660838.
    Citations: 45     Fields:    Translation:AnimalsCells
  162. Palayoor ST, Bump EA, Calderwood SK, Bartol S, Coleman CN. Combined antitumor effect of radiation and ibuprofen in human prostate carcinoma cells. Clin Cancer Res. 1998 Mar; 4(3):763-71. PMID: 9533546.
    Citations: 7     Fields:    Translation:HumansCells
  163. Chen C, Xie Y, Stevenson MA, Auron PE, Calderwood SK. Heat shock factor 1 represses Ras-induced transcriptional activation of the c-fos gene. J Biol Chem. 1997 Oct 24; 272(43):26803-6. PMID: 9341107.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  164. Soncin F, Prevelige R, Calderwood SK. Expression and purification of human heat-shock transcription factor 1. Protein Expr Purif. 1997 Feb; 9(1):27-32. PMID: 9116498.
    Citations: 5     Fields:    Translation:HumansCells
  165. Cahill CM, Lin HS, Price BD, Bruce JL, Calderwood SK. Potential role of heat shock transcription factor in the expression of inflammatory cytokines. Adv Exp Med Biol. 1997; 400B:625-30. PMID: 9547613.
    Citations: 5     Fields:    Translation:HumansCells
  166. Soncin F, Calderwood SK. Reciprocal effects of pro-inflammatory stimuli and anti-inflammatory drugs on the activity of heat shock factor-1 in human monocytes. Biochem Biophys Res Commun. 1996 Dec 13; 229(2):479-84. PMID: 8954923.
    Citations: 3     Fields:    Translation:HumansCells
  167. Chu B, Soncin F, Price BD, Stevenson MA, Calderwood SK. Sequential phosphorylation by mitogen-activated protein kinase and glycogen synthase kinase 3 represses transcriptional activation by heat shock factor-1. J Biol Chem. 1996 Nov 29; 271(48):30847-57. PMID: 8940068.
    Citations: 94     Fields:    Translation:HumansCells
  168. Cahill CM, Waterman WR, Xie Y, Auron PE, Calderwood SK. Transcriptional repression of the prointerleukin 1beta gene by heat shock factor 1. J Biol Chem. 1996 Oct 04; 271(40):24874-9. PMID: 8926278.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  169. Di YP, Repasky E, Laszlo A, Calderwood S, Subjeck J. Hsp70 translocates into a cytoplasmic aggregate during lymphocyte activation. J Cell Physiol. 1995 Nov; 165(2):228-38. PMID: 7593200.
    Citations: 5     Fields:    Translation:AnimalsCells
  170. Nunes SL, Calderwood SK. Heat shock factor-1 and the heat shock cognate 70 protein associate in high molecular weight complexes in the cytoplasm of NIH-3T3 cells. Biochem Biophys Res Commun. 1995 Aug 04; 213(1):1-6. PMID: 7639722.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  171. Stevenson MA, Pollock SS, Coleman CN, Calderwood SK. X-irradiation, phorbol esters, and H2O2 stimulate mitogen-activated protein kinase activity in NIH-3T3 cells through the formation of reactive oxygen intermediates. Cancer Res. 1994 Jan 01; 54(1):12-5. PMID: 8261431.
    Citations: 24     Fields:    Translation:AnimalsCells
  172. Price BD, Calderwood SK. Increased sequence-specific p53-DNA binding activity after DNA damage is attenuated by phorbol esters. Oncogene. 1993 Nov; 8(11):3055-62. PMID: 8414506.
    Citations: 8     Fields:    Translation:AnimalsCells
  173. Calderwood SK, Stevenson MA, Price BD. Activation of phospholipase C by heat shock requires GTP analogs and is resistant to pertussis toxin. J Cell Physiol. 1993 Jul; 156(1):153-9. PMID: 8314854.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  174. Tishler RB, Calderwood SK, Coleman CN, Price BD. Increases in sequence specific DNA binding by p53 following treatment with chemotherapeutic and DNA damaging agents. Cancer Res. 1993 May 15; 53(10 Suppl):2212-6. PMID: 8485705.
    Citations: 41     Fields:    Translation:AnimalsCells
  175. Calderwood SK, Stevenson MA. Inducers of the heat shock response stimulate phospholipase C and phospholipase A2 activity in mammalian cells. J Cell Physiol. 1993 May; 155(2):248-56. PMID: 8482717.
    Citations: 4     Fields:    Translation:AnimalsCells
  176. Bruce JL, Price BD, Coleman CN, Calderwood SK. Oxidative injury rapidly activates the heat shock transcription factor but fails to increase levels of heat shock proteins. Cancer Res. 1993 Jan 01; 53(1):12-5. PMID: 8416735.
    Citations: 29     Fields:    Translation:AnimalsCells
  177. Price BD, Calderwood SK. Heat-induced transcription from RNA polymerases II and III and HSF binding activity are co-ordinately regulated by the products of the heat shock genes. J Cell Physiol. 1992 Nov; 153(2):392-401. PMID: 1385451.
    Citations: 11     Fields:    Translation:AnimalsCells
  178. Price BD, Mannheim-Rodman LA, Calderwood SK. Brefeldin A, thapsigargin, and AIF4- stimulate the accumulation of GRP78 mRNA in a cycloheximide dependent manner, whilst induction by hypoxia is independent of protein synthesis. J Cell Physiol. 1992 Sep; 152(3):545-52. PMID: 1506413.
    Citations: 24     Fields:    Translation:AnimalsCells
  179. Price BD, Calderwood SK. Gadd45 and Gadd153 messenger RNA levels are increased during hypoxia and after exposure of cells to agents which elevate the levels of the glucose-regulated proteins. Cancer Res. 1992 Jul 01; 52(13):3814-7. PMID: 1617653.
    Citations: 53     Fields:    Translation:Animals
  180. Lam KT, Calderwood SK. hsp70 binds specifically to a peptide derived from the highly conserved domain (I) region of p53. Biochem Biophys Res Commun. 1992 Apr 15; 184(1):167-74. PMID: 1567424.
    Citations: 3     Fields: