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profileRichard Steven Blumberg, M.D.

TitleProfessor of Medicine
InstitutionBrigham and Women's Hospital
DepartmentMedicine
AddressBrigham and Women's Hospital
Medicine GI Div
75 Francis St
Boston MA 02115
Phone617/732-6917
Fax617/264-5185
vCardDownload vCard (login for email)

Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R13AI122628     (BLUMBERG, RICHARD S.)Feb 15, 2016 - Apr 25, 2016
NIH/NIAID
2016 Antibody Biology and Engineering Gordon Research Conference & Gordon Research Seminar
Role: Principal Investigator

R01DK088199     (BLUMBERG, RICHARD S.)May 1, 2010 - Aug 31, 2019
NIH/NIDDK
Endoplasmic reticulum stress and intestinal inflammation
Role: Principal Investigator

R13DK084713     (BLUMBERG, RICHARD S)Jul 20, 2009 - Jun 30, 2010
NIH/NIDDK
14th International Congress of Mucosal Immunology
Role: Principal Investigator

U19AI046130     (KHOURY, SAMIA J.)Sep 28, 1999 - Mar 31, 2008
NIH/NIAID
Treatment of Autoimmune Disease by Costimulatory Signal*
Role: Co-Principal Investigator

R01DK053056     (BLUMBERG, RICHARD S.)Sep 1, 1997 - Jun 30, 2017
NIH/NIDDK
Intestinal Immune Regulation by IgG and FcRn
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Hosomi S, Grootjans J, Tschurtschenthaler M, Krupka N, Matute JD, Flak MB, Martinez-Naves E, Gomez Del Moral M, Glickman JN, Ohira M, Lanier LL, Kaser A, Blumberg R. Intestinal epithelial cell endoplasmic reticulum stress promotes MULT1 up-regulation and NKG2D-mediated inflammation. J Exp Med. 2017 Jul 26. PMID: 28747426.
    View in: PubMed
  2. Dankner M, Gray-Owen SD, Huang YH, Blumberg RS, Beauchemin N. CEACAM1 as a multi-purpose target for cancer immunotherapy. Oncoimmunology. 2017; 6(7):e1328336. PMID: 28811966.
    View in: PubMed
  3. Kim WM, Kaser A, Blumberg RS. A role for oncostatin M in inflammatory bowel disease. Nat Med. 2017 May 05; 23(5):535-536. PMID: 28475567.
    View in: PubMed
  4. Gensollen T, Blumberg RS. Correlation between early-life regulation of the immune system by microbiota and allergy development. J Allergy Clin Immunol. 2017 Apr; 139(4):1084-1091. PMID: 28390575.
    View in: PubMed
  5. Ueshima C, Kataoka TR, Takei Y, Hirata M, Sugimoto A, Hirokawa M, Okayama Y, Blumberg RS, Haga H. CEACAM1 long isoform has opposite effects on the growth of human mastocytosis and medullary thyroid carcinoma cells. Cancer Med. 2017 Apr; 6(4):845-856. PMID: 28332308.
    View in: PubMed
  6. Pyzik M, Rath T, Kuo TT, Win S, Baker K, Hubbard JJ, Grenha R, Gandhi A, Krämer TD, Mezo AR, Taylor ZS, McDonnell K, Nienaber V, Andersen JT, Mizoguchi A, Blumberg L, Purohit S, Jones SD, Christianson G, Lencer WI, Sandlie I, Kaplowitz N, Roopenian DC, Blumberg RS. Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury. Proc Natl Acad Sci U S A. 2017 Apr 04; 114(14):E2862-E2871. PMID: 28330995.
    View in: PubMed
  7. Schrumpf E, Jiang X, Zeissig S, Pollheimer MJ, Anmarkrud JA, Tan C, Exley MA, Karlsen TH, Blumberg RS, Melum E. The role of natural killer T cells in a mouse model with spontaneous bile duct inflammation. Physiol Rep. 2017 Feb; 5(4). PMID: 28219981.
    View in: PubMed
  8. Tschurtschenthaler M, Adolph TE, Ashcroft JW, Niederreiter L, Bharti R, Saveljeva S, Bhattacharyya J, Flak MB, Shih DQ, Fuhler GM, Parkes M, Kohno K, Iwawaki T, Janneke van der Woude C, Harding HP, Smith AM, Peppelenbosch MP, Targan SR, Ron D, Rosenstiel P, Blumberg RS, Kaser A. Defective ATG16L1-mediated removal of IRE1a drives Crohn's disease-like ileitis. J Exp Med. 2017 Feb; 214(2):401-422. PMID: 28082357.
    View in: PubMed
  9. Zeissig Y, Petersen BS, Franke A, Blumberg RS, Zeissig S. Rare phenotypes in the understanding of autoimmunity. Immunol Cell Biol. 2016 Nov; 94(10):943-948. PMID: 27562064.
    View in: PubMed
  10. Schrumpf E, Kummen M, Valestrand L, Greiner TU, Holm K, Arulampalam V, Reims HM, Baines J, Bäckhed F, Karlsen TH, Blumberg RS, Hov JR, Melum E. The gut microbiota contributes to a mouse model of spontaneous bile duct inflammation. J Hepatol. 2017 Feb; 66(2):382-389. PMID: 27720803.
    View in: PubMed
  11. Nakanishi Y, Reina-Campos M, Nakanishi N, Llado V, Elmen L, Peterson S, Campos A, De SK, Leitges M, Ikeuchi H, Pellecchia M, Blumberg RS, Diaz-Meco MT, Moscat J. Control of Paneth Cell Fate, Intestinal Inflammation, and Tumorigenesis by PKC?/?. Cell Rep. 2016 Sep 20; 16(12):3297-3310. PMID: 27653691.
    View in: PubMed
  12. Aden K, Rehman A, Falk-Paulsen M, Secher T, Kuiper J, Tran F, Pfeuffer S, Sheibani-Tezerji R, Breuer A, Luzius A, Jentzsch M, Häsler R, Billmann-Born S, Will O, Lipinski S, Bharti R, Adolph T, Iovanna JL, Kempster SL, Blumberg RS, Schreiber S, Becher B, Chamaillard M, Kaser A, Rosenstiel P. Epithelial IL-23R Signaling Licenses Protective IL-22 Responses in Intestinal Inflammation. Cell Rep. 2016 Aug 23; 16(8):2208-2218. PMID: 27524624.
    View in: PubMed
  13. Mudde AC, Lexmond WS, Blumberg RS, Nurko S, Fiebiger E. Eosinophilic esophagitis: published evidences for disease subtypes, indications for patient subpopulations, and how to translate patient observations to murine experimental models. World Allergy Organ J. 2016; 9:23. PMID: 27458501; PMCID: PMC4947322.
  14. Grootjans J, Kaser A, Kaufman RJ, Blumberg RS. The unfolded protein response in immunity and inflammation. Nat Rev Immunol. 2016 08; 16(8):469-84. PMID: 27346803.
    View in: PubMed
  15. Vitenshtein A, Weisblum Y, Hauka S, Halenius A, Oiknine-Djian E, Tsukerman P, Bauman Y, Bar-On Y, Stern-Ginossar N, Enk J, Ortenberg R, Tai J, Markel G, Blumberg RS, Hengel H, Jonjic S, Wolf DG, Adler H, Kammerer R, Mandelboim O. CEACAM1-Mediated Inhibition of Virus Production. Cell Rep. 2016 Jun 14; 15(11):2331-9. PMID: 27264178; PMCID: PMC4914772.
  16. Gensollen T, Iyer SS, Kasper DL, Blumberg RS. How colonization by microbiota in early life shapes the immune system. Science. 2016 Apr 29; 352(6285):539-44. PMID: 27126036.
    View in: PubMed
  17. Peuker K, Muff S, Wang J, Künzel S, Bosse E, Zeissig Y, Luzzi G, Basic M, Strigli A, Ulbricht A, Kaser A, Arlt A, Chavakis T, van den Brink GR, Schafmayer C, Egberts JH, Becker T, Bianchi ME, Bleich A, Röcken C, Hampe J, Schreiber S, Baines JF, Blumberg RS, Zeissig S. Epithelial calcineurin controls microbiota-dependent intestinal tumor development. Nat Med. 2016 May; 22(5):506-15. PMID: 27043494.
    View in: PubMed
  18. Huang YH, Zhu C, Kondo Y, Anderson AC, Gandhi A, Russell A, Dougan SK, Petersen BS, Melum E, Pertel T, Clayton KL, Raab M, Chen Q, Beauchemin N, Yazaki PJ, Pyzik M, Ostrowski MA, Glickman JN, Rudd CE, Ploegh HL, Franke A, Petsko GA, Kuchroo VK, Blumberg RS. Corrigendum: CEACAM1 regulates TIM-3-mediated tolerance and exhaustion. Nature. 2016 08 18; 536(7616):359. PMID: 26982724.
    View in: PubMed
  19. Blumberg RS. Environment and Genes: What Is the Interaction? Dig Dis. 2016; 34(1-2):20-6. PMID: 26982321; PMCID: PMC4896159.
  20. Grover S, Lim RM, Blumberg RS, Syngal S. Oncogastroenterology. J Clin Oncol. 2016 Apr 01; 34(10):1154-5. PMID: 26834060.
    View in: PubMed
  21. Lin JE, Colon-Gonzalez F, Blomain E, Kim GW, Aing A, Stoecker B, Rock J, Snook AE, Zhan T, Hyslop TM, Tomczak M, Blumberg RS, Waldman SA. Obesity-Induced Colorectal Cancer Is Driven by Caloric Silencing of the Guanylin-GUCY2C Paracrine Signaling Axis. Cancer Res. 2016 Jan 15; 76(2):339-46. PMID: 26773096; PMCID: PMC4717834 [Available on 01/15/17].
  22. Krishnamoorthy S, Liu T, Drager D, Patarroyo-White S, Chhabra ES, Peters R, Josephson N, Lillicrap D, Blumberg RS, Pierce GF, Jiang H. Recombinant factor VIII Fc (rFVIIIFc) fusion protein reduces immunogenicity and induces tolerance in hemophilia A mice. Cell Immunol. 2016 Mar; 301:30-9. PMID: 26775174; PMCID: PMC4936482.
  23. Grootjans J, Hosomi S, Blumberg RS. Leukotrienes and the other airway: Celiac disease and asthma collide. J Exp Med. 2015 Sep 21; 212(10):1485. PMID: 26392429; PMCID: PMC4577843.
  24. Bundhoo A, Paveglio S, Rafti E, Dhongade A, Blumberg RS, Matson AP. Evidence that FcRn mediates the transplacental passage of maternal IgE in the form of IgG anti-IgE/IgE immune complexes. Clin Exp Allergy. 2015 Jun; 45(6):1085-98. PMID: 25652137; PMCID: PMC4437844.
  25. Schrumpf E, Tan C, Karlsen TH, Sponheim J, Björkström NK, Sundnes O, Alfsnes K, Kaser A, Jefferson DM, Ueno Y, Eide TJ, Haraldsen G, Zeissig S, Exley MA, Blumberg RS, Melum E. The biliary epithelium presents antigens to and activates natural killer T cells. Hepatology. 2015 Oct; 62(4):1249-59. PMID: 25855031; PMCID: PMC4589438 [Available on 10/01/16].
  26. Dowds CM, Blumberg RS, Zeissig S. Control of intestinal homeostasis through crosstalk between natural killer T cells and the intestinal microbiota. Clin Immunol. 2015 Aug; 159(2):128-33. PMID: 25988859; PMCID: PMC4817350.
  27. Pyzik M, Rath T, Lencer WI, Baker K, Blumberg RS. FcRn: The Architect Behind the Immune and Nonimmune Functions of IgG and Albumin. J Immunol. 2015 May 15; 194(10):4595-603. PMID: 25934922; PMCID: PMC4451002.
  28. Platzer B, Elpek KG, Cremasco V, Baker K, Stout MM, Schultz C, Dehlink E, Shade KT, Anthony RM, Blumberg RS, Turley SJ, Fiebiger E. IgE/FceRI-Mediated Antigen Cross-Presentation by Dendritic Cells Enhances Anti-Tumor Immune Responses. Cell Rep. 2015 Mar 03. PMID: 25753415.
    View in: PubMed
  29. Arabzadeh A, Dupaul-Chicoine J, Breton V, Haftchenary S, Yumeen S, Turbide C, Saleh M, McGregor K, Greenwood CM, Akavia UD, Blumberg RS, Gunning PT, Beauchemin N. Carcinoembryonic Antigen Cell Adhesion Molecule 1 long isoform modulates malignancy of poorly differentiated colon cancer cells. Gut. 2016 May; 65(5):821-9. PMID: 25666195; PMCID: PMC4826327.
  30. Rath T, Baker K, Pyzik M, Blumberg RS. Regulation of immune responses by the neonatal fc receptor and its therapeutic implications. Front Immunol. 2014; 5:664. PMID: 25601863; PMCID: PMC4283642.
  31. Hosomi S, Kaser A, Blumberg RS. Role of endoplasmic reticulum stress and autophagy as interlinking pathways in the pathogenesis of inflammatory bowel disease. Curr Opin Gastroenterol. 2015 Jan; 31(1):81-8. PMID: 25426970; PMCID: PMC4592163.
  32. Zeissig S, Petersen BS, Tomczak M, Melum E, Huc-Claustre E, Dougan SK, Laerdahl JK, Stade B, Forster M, Schreiber S, Weir D, Leichtner AM, Franke A, Blumberg RS. Early-onset Crohn's disease and autoimmunity associated with a variant in CTLA-4. Gut. 2015 Dec; 64(12):1889-97. PMID: 25367873; PMCID: PMC4512923 [Available on 12/01/16].
  33. Huang YH, Zhu C, Kondo Y, Anderson AC, Gandhi A, Russell A, Dougan SK, Petersen BS, Melum E, Pertel T, Clayton KL, Raab M, Chen Q, Beauchemin N, Yazaki PJ, Pyzik M, Ostrowski MA, Glickman JN, Rudd CE, Ploegh HL, Franke A, Petsko GA, Kuchroo VK, Blumberg RS. CEACAM1 regulates TIM-3-mediated tolerance and exhaustion. Nature. 2015 01 15; 517(7534):386-90. PMID: 25363763; PMCID: PMC4297519.
  34. Platzer B, Baker K, Vera MP, Singer K, Panduro M, Lexmond WS, Turner D, Vargas SO, Kinet JP, Maurer D, Baron RM, Blumberg RS, Fiebiger E. Dendritic cell-bound IgE functions to restrain allergic inflammation at mucosal sites. Mucosal Immunol. 2015 May; 8(3):516-32. PMID: 25227985; PMCID: PMC4363306.
  35. Baker K, Rath T, Pyzik M, Blumberg RS. The Role of FcRn in Antigen Presentation. Front Immunol. 2014; 5:408. PMID: 25221553; PMCID: PMC4145246.
  36. Ko SY, Pegu A, Rudicell RS, Yang ZY, Joyce MG, Chen X, Wang K, Bao S, Kraemer TD, Rath T, Zeng M, Schmidt SD, Todd JP, Penzak SR, Saunders KO, Nason MC, Haase AT, Rao SS, Blumberg RS, Mascola JR, Nabel GJ. Enhanced neonatal Fc receptor function improves protection against primate SHIV infection. Nature. 2014 Oct 30; 514(7524):642-5. PMID: 25119033; PMCID: PMC4433741.
  37. Zeissig S, Blumberg RS. Commensal microbial regulation of natural killer T cells at the frontiers of the mucosal immune system. FEBS Lett. 2014 Nov 17; 588(22):4188-94. PMID: 24983499.
    View in: PubMed
  38. Olszak T, Neves JF, Dowds CM, Baker K, Glickman J, Davidson NO, Lin CS, Jobin C, Brand S, Sotlar K, Wada K, Katayama K, Nakajima A, Mizuguchi H, Kawasaki K, Nagata K, Müller W, Snapper SB, Schreiber S, Kaser A, Zeissig S, Blumberg RS. Protective mucosal immunity mediated by epithelial CD1d and IL-10. Nature. 2014 May 22; 509(7501):497-502. PMID: 24717441; PMCID: PMC4132962.
  39. Zeissig S, Blumberg RS. Life at the beginning: perturbation of the microbiota by antibiotics in early life and its role in health and disease. Nat Immunol. 2014 Apr; 15(4):307-10. PMID: 24646587.
    View in: PubMed
  40. Kaser A, Blumberg RS. Cell biology: Stressful genetics in Crohn's disease. Nature. 2014 Feb 27; 506(7489):441-2. PMID: 24553137; PMCID: PMC4420161.
  41. Baker K, Rath T, Pyzik M, Blumberg RS. Neonatal Fc receptors for IgG drive CD8+ T cell-mediated anti-cancer immunosurveillance at tolerogenic mucosal sites. Oncoimmunology. 2014; 3:e27844. PMID: 25339998.
    View in: PubMed
  42. Lexmond WS, Neves JF, Nurko S, Olszak T, Exley MA, Blumberg RS, Fiebiger E. Involvement of the iNKT cell pathway is associated with early-onset eosinophilic esophagitis and response to allergen avoidance therapy. Am J Gastroenterol. 2014 May; 109(5):646-57. PMID: 24513807; PMCID: PMC4132949.
  43. Afrazi A, Branca MF, Sodhi CP, Good M, Yamaguchi Y, Egan CE, Lu P, Jia H, Shaffiey S, Lin J, Ma C, Vincent G, Prindle T, Weyandt S, Neal MD, Ozolek JA, Wiersch J, Tschurtschenthaler M, Shiota C, Gittes GK, Billiar TR, Mollen K, Kaser A, Blumberg R, Hackam DJ. Toll-like receptor 4-mediated endoplasmic reticulum stress in intestinal crypts induces necrotizing enterocolitis. J Biol Chem. 2014 Apr 04; 289(14):9584-99. PMID: 24519940; PMCID: PMC3975009.
  44. Armitage CW, O'Meara CP, Harvie MC, Timms P, Blumberg RS, Beagley KW. Divergent outcomes following transcytosis of IgG targeting intracellular and extracellular chlamydial antigens. Immunol Cell Biol. 2014 May-Jun; 92(5):417-26. PMID: 24445600; PMCID: PMC4088937.
  45. An D, Oh SF, Olszak T, Neves JF, Avci FY, Erturk-Hasdemir D, Lu X, Zeissig S, Blumberg RS, Kasper DL. Sphingolipids from a symbiotic microbe regulate homeostasis of host intestinal natural killer T cells. Cell. 2014 Jan 16; 156(1-2):123-33. PMID: 24439373; PMCID: PMC3909465.
  46. Dowds CM, Kornell SC, Blumberg RS, Zeissig S. Lipid antigens in immunity. Biol Chem. 2014 Jan; 395(1):61-81. PMID: 23999493; PMCID: PMC4128234.
  47. Kaser A, Blumberg RS. ATG16L1 Crohn's disease risk stresses the endoplasmic reticulum of Paneth cells. Gut. 2014 Jul; 63(7):1038-9. PMID: 24304670; PMCID: PMC4045658.
  48. Pridgen EM, Alexis F, Kuo TT, Levy-Nissenbaum E, Karnik R, Blumberg RS, Langer R, Farokhzad OC. Transepithelial transport of Fc-targeted nanoparticles by the neonatal fc receptor for oral delivery. Sci Transl Med. 2013 Nov 27; 5(213):213ra167. PMID: 24285486; PMCID: PMC4023672.
  49. Baker K, Rath T, Flak MB, Arthur JC, Chen Z, Glickman JN, Zlobec I, Karamitopoulou E, Stachler MD, Odze RD, Lencer WI, Jobin C, Blumberg RS. Neonatal Fc receptor expression in dendritic cells mediates protective immunity against colorectal cancer. Immunity. 2013 Dec 12; 39(6):1095-107. PMID: 24290911; PMCID: PMC3902970.
  50. Zeissig S, Blumberg RS. Commensal microbiota and NKT cells in the control of inflammatory diseases at mucosal surfaces. Curr Opin Immunol. 2013 Dec; 25(6):690-6. PMID: 24210255; PMCID: PMC3867259.
  51. Rath T, Baker K, Dumont JA, Peters RT, Jiang H, Qiao SW, Lencer WI, Pierce GF, Blumberg RS. Fc-fusion proteins and FcRn: structural insights for longer-lasting and more effective therapeutics. Crit Rev Biotechnol. 2015 Jun; 35(2):235-54. PMID: 24156398; PMCID: PMC4876602.
  52. Adolph TE, Tomczak MF, Niederreiter L, Ko HJ, Böck J, Martinez-Naves E, Glickman JN, Tschurtschenthaler M, Hartwig J, Hosomi S, Flak MB, Cusick JL, Kohno K, Iwawaki T, Billmann-Born S, Raine T, Bharti R, Lucius R, Kweon MN, Marciniak SJ, Choi A, Hagen SJ, Schreiber S, Rosenstiel P, Kaser A, Blumberg RS. Paneth cells as a site of origin for intestinal inflammation. Nature. 2013 Nov 14; 503(7475):272-6. PMID: 24089213; PMCID: PMC3862182.
  53. Niederreiter L, Fritz TM, Adolph TE, Krismer AM, Offner FA, Tschurtschenthaler M, Flak MB, Hosomi S, Tomczak MF, Kaneider NC, Sarcevic E, Kempster SL, Raine T, Esser D, Rosenstiel P, Kohno K, Iwawaki T, Tilg H, Blumberg RS, Kaser A. ER stress transcription factor Xbp1 suppresses intestinal tumorigenesis and directs intestinal stem cells. J Exp Med. 2013 Sep 23; 210(10):2041-56. PMID: 24043762; PMCID: PMC3782039.
  54. Hosomi S, Chen Z, Baker K, Chen L, Huang YH, Olszak T, Zeissig S, Wang JH, Mandelboim O, Beauchemin N, Lanier LL, Blumberg RS. CEACAM1 on activated NK cells inhibits NKG2D-mediated cytolytic function and signaling. Eur J Immunol. 2013 Sep; 43(9):2473-83. PMID: 23696226; PMCID: PMC3775953.
  55. Weflen AW, Baier N, Tang QJ, Van den Hof M, Blumberg RS, Lencer WI, Massol RH. Multivalent immune complexes divert FcRn to lysosomes by exclusion from recycling sorting tubules. Mol Biol Cell. 2013 Aug; 24(15):2398-405. PMID: 23741050; PMCID: PMC3727932.
  56. Garn H, Neves JF, Blumberg RS, Renz H. Effect of barrier microbes on organ-based inflammation. J Allergy Clin Immunol. 2013 Jun; 131(6):1465-78. PMID: 23726530; PMCID: PMC4592166.
  57. Kaser A, Blumberg RS. Introduction: the unfolded protein response's role in disease pathophysiology. Semin Immunopathol. 2013 May; 35(3):255-7. PMID: 23609501; PMCID: PMC4592140.
  58. Kaser A, Adolph TE, Blumberg RS. The unfolded protein response and gastrointestinal disease. Semin Immunopathol. 2013 May; 35(3):307-19. PMID: 23588234; PMCID: PMC3661271.
  59. Flak MB, Neves JF, Blumberg RS. Immunology. Welcome to the microgenderome. Science. 2013 Mar 01; 339(6123):1044-5. PMID: 23449586; PMCID: PMC4005781.
  60. Zeissig S, Olszak T, Melum E, Blumberg RS. Analyzing antigen recognition by Natural Killer T cells. Methods Mol Biol. 2013; 960:557-572. PMID: 23329514; PMCID: PMC3708615.
  61. Nishida A, Nagahama K, Imaeda H, Ogawa A, Lau CW, Kobayashi T, Hisamatsu T, Preffer FI, Mizoguchi E, Ikeuchi H, Hibi T, Fukuda M, Andoh A, Blumberg RS, Mizoguchi A. Inducible colitis-associated glycome capable of stimulating the proliferation of memory CD4+ T cells. J Exp Med. 2012 Dec 17; 209(13):2383-94. PMID: 23209314; PMCID: PMC3526363.
  62. Chen L, Chen Z, Baker K, Halvorsen EM, da Cunha AP, Flak MB, Gerber G, Huang YH, Hosomi S, Arthur JC, Dery KJ, Nagaishi T, Beauchemin N, Holmes KV, Ho JW, Shively JE, Jobin C, Onderdonk AB, Bry L, Weiner HL, Higgins DE, Blumberg RS. The short isoform of the CEACAM1 receptor in intestinal T cells regulates mucosal immunity and homeostasis via Tfh cell induction. Immunity. 2012 Nov 16; 37(5):930-46. PMID: 23123061; PMCID: PMC3516394.
  63. Rath T, Kuo TT, Baker K, Qiao SW, Kobayashi K, Yoshida M, Roopenian D, Fiebiger E, Lencer WI, Blumberg RS. The immunologic functions of the neonatal Fc receptor for IgG. J Clin Immunol. 2013 Jan; 33 Suppl 1:S9-17. PMID: 22948741; PMCID: PMC3548031.
  64. Baker K, Rath T, Lencer WI, Fiebiger E, Blumberg RS. Cross-presentation of IgG-containing immune complexes. Cell Mol Life Sci. 2013 Apr; 70(8):1319-34. PMID: 22847331; PMCID: PMC3609906.
  65. Adolph TE, Niederreiter L, Blumberg RS, Kaser A. Endoplasmic reticulum stress and inflammation. Dig Dis. 2012; 30(4):341-6. PMID: 22796794; PMCID: PMC3423328.
  66. Zeissig S, Murata K, Sweet L, Publicover J, Hu Z, Kaser A, Bosse E, Iqbal J, Hussain MM, Balschun K, Röcken C, Arlt A, Günther R, Hampe J, Schreiber S, Baron JL, Moody DB, Liang TJ, Blumberg RS. Hepatitis B virus-induced lipid alterations contribute to natural killer T cell-dependent protective immunity. Nat Med. 2012 Jul; 18(7):1060-8. PMID: 22706385; PMCID: PMC3478098.
  67. Blumberg R, Powrie F. Microbiota, disease, and back to health: a metastable journey. Sci Transl Med. 2012 Jun 06; 4(137):137rv7. PMID: 22674557; PMCID: PMC5020897.
  68. Mayer L, Kaser A, Blumberg RS. Dead on arrival: understanding the failure of CTLA4-immunoglobulin therapy in inflammatory bowel disease. Gastroenterology. 2012 Jul; 143(1):13-7. PMID: 22626501; PMCID: PMC3392152.
  69. Olszak T, An D, Zeissig S, Vera MP, Richter J, Franke A, Glickman JN, Siebert R, Baron RM, Kasper DL, Blumberg RS. Microbial exposure during early life has persistent effects on natural killer T cell function. Science. 2012 Apr 27; 336(6080):489-93. PMID: 22442383; PMCID: PMC3437652.
  70. Khatun I, Zeissig S, Iqbal J, Wang M, Curiel D, Shelness GS, Blumberg RS, Hussain MM. Phospholipid transfer activity of microsomal triglyceride transfer protein produces apolipoprotein B and reduces hepatosteatosis while maintaining low plasma lipids in mice. Hepatology. 2012 May; 55(5):1356-68. PMID: 22121032; PMCID: PMC3299931.
  71. Zeissig S, Blumberg RS. Primary immunodeficiency associated with defects in CD1 and CD1-restricted T cells. Ann N Y Acad Sci. 2012 Feb; 1250:14-24. PMID: 22276638.
    View in: PubMed
  72. Blumberg RS, Dittel B, Hafler D, von Herrath M, Nestle FO. Unraveling the autoimmune translational research process layer by layer. Nat Med. 2012 Jan 06; 18(1):35-41. PMID: 22227670; PMCID: PMC4592149.
  73. Hamilton MJ, Snapper SB, Blumberg RS. Update on biologic pathways in inflammatory bowel disease and their therapeutic relevance. J Gastroenterol. 2012 Jan; 47(1):1-8. PMID: 22215058; PMCID: PMC4592148.
  74. Chen Z, Chen L, Baker K, Olszak T, Zeissig S, Huang YH, Kuo TT, Mandelboim O, Beauchemin N, Lanier LL, Blumberg RS. CEACAM1 dampens antitumor immunity by down-regulating NKG2D ligand expression on tumor cells. J Exp Med. 2011 Dec 19; 208(13):2633-40. PMID: 22143889; PMCID: PMC3244030.
  75. Ben Suleiman Y, Yoshida M, Nishiumi S, Tanaka H, Mimura T, Nobutani K, Yamamoto K, Takenaka M, Aoganghua A, Miki I, Ota H, Takahashi S, Matsui H, Nakamura M, Blumberg RS, Azuma T. Neonatal Fc receptor for IgG (FcRn) expressed in the gastric epithelium regulates bacterial infection in mice. Mucosal Immunol. 2012 Jan; 5(1):87-98. PMID: 22089027; PMCID: PMC3964614.
  76. Diegelmann J, Olszak T, Göke B, Blumberg RS, Brand S. A novel role for interleukin-27 (IL-27) as mediator of intestinal epithelial barrier protection mediated via differential signal transducer and activator of transcription (STAT) protein signaling and induction of antibacterial and anti-inflammatory proteins. J Biol Chem. 2012 Jan 02; 287(1):286-98. PMID: 22069308; PMCID: PMC3249079.
  77. Kaser A, Niederreiter L, Blumberg RS. Genetically determined epithelial dysfunction and its consequences for microflora-host interactions. Cell Mol Life Sci. 2011 Nov; 68(22):3643-9. PMID: 21984606; PMCID: PMC4592146.
  78. Fredenburgh LE, Velandia MM, Ma J, Olszak T, Cernadas M, Englert JA, Chung SW, Liu X, Begay C, Padera RF, Blumberg RS, Walsh SR, Baron RM, Perrella MA. Cyclooxygenase-2 deficiency leads to intestinal barrier dysfunction and increased mortality during polymicrobial sepsis. J Immunol. 2011 Nov 15; 187(10):5255-67. PMID: 21967897; PMCID: PMC3208135.
  79. Yang VW, Blumberg RS. "What color is my parachute": career opportunities in academic gastroenterology and hepatology. Gastroenterology. 2011 Oct; 141(4):1138-41. PMID: 21864476; PMCID: PMC3267832.
  80. Wirtz S, Billmeier U, Mchedlidze T, Blumberg RS, Neurath MF. Interleukin-35 mediates mucosal immune responses that protect against T-cell-dependent colitis. Gastroenterology. 2011 Nov; 141(5):1875-86. PMID: 21820391; PMCID: PMC3624892.
  81. Kaser A, Flak MB, Tomczak MF, Blumberg RS. The unfolded protein response and its role in intestinal homeostasis and inflammation. Exp Cell Res. 2011 Nov 15; 317(19):2772-9. PMID: 21821022; PMCID: PMC3392150.
  82. Lu SX, Kappel LW, Charbonneau-Allard AM, Atallah R, Holland AM, Turbide C, Hubbard VM, Rotolo JA, Smith M, Suh D, King C, Rao UK, Yim N, Bautista JL, Jenq RR, Penack O, Na IK, Liu C, Murphy G, Alpdogan O, Blumberg RS, Macian F, Holmes KV, Beauchemin N, van den Brink MR. Ceacam1 separates graft-versus-host-disease from graft-versus-tumor activity after experimental allogeneic bone marrow transplantation. PLoS One. 2011; 6(7):e21611. PMID: 21760897; PMCID: PMC3130781.
  83. Baker K, Qiao SW, Kuo TT, Aveson VG, Platzer B, Andersen JT, Sandlie I, Chen Z, de Haar C, Lencer WI, Fiebiger E, Blumberg RS. Neonatal Fc receptor for IgG (FcRn) regulates cross-presentation of IgG immune complexes by CD8-CD11b+ dendritic cells. Proc Natl Acad Sci U S A. 2011 Jun 14; 108(24):9927-32. PMID: 21628593; PMCID: PMC3116387.
  84. Kaser A, Blumberg RS. Autophagy, microbial sensing, endoplasmic reticulum stress, and epithelial function in inflammatory bowel disease. Gastroenterology. 2011 May; 140(6):1738-47. PMID: 21530740; PMCID: PMC4592160.
  85. Blumberg R, Cho J, Lewis J, Wu G. Inflammatory bowel disease: an update on the fundamental biology and clinical management. Gastroenterology. 2011 May; 140(6):1701-3. PMID: 21530735.
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  86. Kaser A, Blumberg RS. Lessons from type I interferons in ulcerative colitis. Gut. 2011 Apr; 60(4):430-1. PMID: 21266724; PMCID: PMC4592161.
  87. Fritz T, Niederreiter L, Adolph T, Blumberg RS, Kaser A. Crohn's disease: NOD2, autophagy and ER stress converge. Gut. 2011 Nov; 60(11):1580-8. PMID: 21252204; PMCID: PMC3897479.
  88. Hamilton MJ, Sinnamon MJ, Lyng GD, Glickman JN, Wang X, Xing W, Krilis SA, Blumberg RS, Adachi R, Lee DM, Stevens RL. Essential role for mast cell tryptase in acute experimental colitis. Proc Natl Acad Sci U S A. 2011 Jan 04; 108(1):290-5. PMID: 21173247; PMCID: PMC3017166.
  89. Kaser A, Tomczak M, Blumberg RS. "ER stress(ed out)!": Paneth cells and ischemia-reperfusion injury of the small intestine. Gastroenterology. 2011 Feb; 140(2):393-6. PMID: 21172333; PMCID: PMC4594951.
  90. Kamat A, Ancuta P, Blumberg RS, Gabuzda D. Serological markers for inflammatory bowel disease in AIDS patients with evidence of microbial translocation. PLoS One. 2010 Nov 15; 5(11):e15533. PMID: 21125014; PMCID: PMC2981579.
  91. Fritz T, Niederreiter L, Tilg H, Blumberg RS, Kaser A. Controversy over NOD2, inflammation, and defensins. Inflamm Bowel Dis. 2010 Nov; 16(11):1996-8. PMID: 20128000; PMCID: PMC4592164.
  92. Kuo TT, Baker K, Yoshida M, Qiao SW, Aveson VG, Lencer WI, Blumberg RS. Neonatal Fc receptor: from immunity to therapeutics. J Clin Immunol. 2010 Nov; 30(6):777-89. PMID: 20886282; PMCID: PMC2970823.
  93. Kaser A, Zeissig S, Blumberg RS. Genes and environment: how will our concepts on the pathophysiology of IBD develop in the future? Dig Dis. 2010; 28(3):395-405. PMID: 20926863; PMCID: PMC2980818.
  94. Dougan M, Dougan S, Slisz J, Firestone B, Vanneman M, Draganov D, Goyal G, Li W, Neuberg D, Blumberg R, Hacohen N, Porter D, Zawel L, Dranoff G. IAP inhibitors enhance co-stimulation to promote tumor immunity. J Exp Med. 2010 Sep 27; 207(10):2195-206. PMID: 20837698; PMCID: PMC2947073.
  95. Kaser A, Martínez-Naves E, Blumberg RS. Endoplasmic reticulum stress: implications for inflammatory bowel disease pathogenesis. Curr Opin Gastroenterol. 2010 Jul; 26(4):318-26. PMID: 20495455; PMCID: PMC4592137.
  96. Zeissig S, Dougan SK, Barral DC, Junker Y, Chen Z, Kaser A, Ho M, Mandel H, McIntyre A, Kennedy SM, Painter GF, Veerapen N, Besra GS, Cerundolo V, Yue S, Beladi S, Behar SM, Chen X, Gumperz JE, Breckpot K, Raper A, Baer A, Exley MA, Hegele RA, Cuchel M, Rader DJ, Davidson NO, Blumberg RS. Primary deficiency of microsomal triglyceride transfer protein in human abetalipoproteinemia is associated with loss of CD1 function. J Clin Invest. 2010 Aug; 120(8):2889-99. PMID: 20592474; PMCID: PMC2912200.
  97. Kaser A, Blumberg RS. Survive an innate immune response through XBP1. Cell Res. 2010 May; 20(5):506-7. PMID: 20436510; PMCID: PMC4592167.
  98. Nakata K, Kobayashi K, Ishikawa Y, Yamamoto M, Funada Y, Kotani Y, Blumberg RS, Karasuyama H, Yoshida M, Nishimura Y. The transfer of maternal antigen-specific IgG regulates the development of allergic airway inflammation early in life in an FcRn-dependent manner. Biochem Biophys Res Commun. 2010 Apr 30; 395(2):238-43. PMID: 20362552; PMCID: PMC3990410.
  99. Shiomi H, Masuda A, Nishiumi S, Nishida M, Takagawa T, Shiomi Y, Kutsumi H, Blumberg RS, Azuma T, Yoshida M. Gamma interferon produced by antigen-specific CD4+ T cells regulates the mucosal immune responses to Citrobacter rodentium infection. Infect Immun. 2010 Jun; 78(6):2653-66. PMID: 20351140; PMCID: PMC2876554.
  100. Kaser A, Zeissig S, Blumberg RS. Inflammatory bowel disease. Annu Rev Immunol. 2010; 28:573-621. PMID: 20192811; PMCID: PMC4620040.
  101. Ishida T, Yoshida M, Arita M, Nishitani Y, Nishiumi S, Masuda A, Mizuno S, Takagawa T, Morita Y, Kutsumi H, Inokuchi H, Serhan CN, Blumberg RS, Azuma T. Resolvin E1, an endogenous lipid mediator derived from eicosapentaenoic acid, prevents dextran sulfate sodium-induced colitis. Inflamm Bowel Dis. 2010 Jan; 16(1):87-95. PMID: 19572372; PMCID: PMC3070396.
  102. Inaba K, Fukazawa Y, Matsuda K, Himeno A, Matsuyama M, Ibuki K, Miura Y, Koyanagi Y, Nakajima A, Blumberg RS, Takahashi H, Hayami M, Igarashi T, Miura T. Small intestine CD4+ cell reduction and enteropathy in simian/human immunodeficiency virus KS661-infected rhesus macaques in the presence of low viral load. J Gen Virol. 2010 Mar; 91(Pt 3):773-81. PMID: 19889928; PMCID: PMC3192539.
  103. Blumberg RS. Inflammation in the intestinal tract: pathogenesis and treatment. Dig Dis. 2009; 27(4):455-64. PMID: 19897960; PMCID: PMC3202957.
  104. Kaser A, Blumberg RS. Endoplasmic reticulum stress and intestinal inflammation. Mucosal Immunol. 2010 Jan; 3(1):11-6. PMID: 19865077; PMCID: PMC4592136.
  105. Kobayashi K, Qiao SW, Yoshida M, Baker K, Lencer WI, Blumberg RS. An FcRn-dependent role for anti-flagellin immunoglobulin G in pathogenesis of colitis in mice. Gastroenterology. 2009 Nov; 137(5):1746-56.e1. PMID: 19664634; PMCID: PMC2787451.
  106. Chen Z, Chen L, Blumberg RS. Editorial: CEACAM1: fine-tuned for fine-tuning. J Leukoc Biol. 2009 Aug; 86(2):195-7. PMID: 19643737.
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  107. Liu J, Divoux A, Sun J, Zhang J, Clément K, Glickman JN, Sukhova GK, Wolters PJ, Du J, Gorgun CZ, Doria A, Libby P, Blumberg RS, Kahn BB, Hotamisligil GS, Shi GP. Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice. Nat Med. 2009 Aug; 15(8):940-5. PMID: 19633655; PMCID: PMC2736875.
  108. Baker K, Qiao SW, Kuo T, Kobayashi K, Yoshida M, Lencer WI, Blumberg RS. Immune and non-immune functions of the (not so) neonatal Fc receptor, FcRn. Semin Immunopathol. 2009 Jul; 31(2):223-36. PMID: 19495758; PMCID: PMC3898171.
  109. Tzaban S, Massol RH, Yen E, Hamman W, Frank SR, Lapierre LA, Hansen SH, Goldenring JR, Blumberg RS, Lencer WI. The recycling and transcytotic pathways for IgG transport by FcRn are distinct and display an inherent polarity. J Cell Biol. 2009 May 18; 185(4):673-84. PMID: 19451275; PMCID: PMC2711563.
  110. Nieuwenhuis EE, Matsumoto T, Lindenbergh D, Willemsen R, Kaser A, Simons-Oosterhuis Y, Brugman S, Yamaguchi K, Ishikawa H, Aiba Y, Koga Y, Samsom JN, Oshima K, Kikuchi M, Escher JC, Hattori M, Onderdonk AB, Blumberg RS. Cd1d-dependent regulation of bacterial colonization in the intestine of mice. J Clin Invest. 2009 May; 119(5):1241-50. PMID: 19349688; PMCID: PMC2673876.
  111. Qiao SW, Sollid LM, Blumberg RS. Antigen presentation in celiac disease. Curr Opin Immunol. 2009 Feb; 21(1):111-7. PMID: 19342211; PMCID: PMC3901576.
  112. Masuda A, Yoshida M, Shiomi H, Morita Y, Kutsumi H, Inokuchi H, Mizuno S, Nakamura A, Takai T, Blumberg RS, Azuma T. Role of Fc Receptors as a therapeutic target. Inflamm Allergy Drug Targets. 2009 Mar; 8(1):80-6. PMID: 19275696; PMCID: PMC3990358.
  113. Kaser A, Blumberg RS. Endoplasmic reticulum stress in the intestinal epithelium and inflammatory bowel disease. Semin Immunol. 2009 Jun; 21(3):156-63. PMID: 19237300; PMCID: PMC4736746.
  114. Kuo TT, de Muinck EJ, Claypool SM, Yoshida M, Nagaishi T, Aveson VG, Lencer WI, Blumberg RS. N-Glycan Moieties in Neonatal Fc Receptor Determine Steady-state Membrane Distribution and Directional Transport of IgG. J Biol Chem. 2009 Mar 27; 284(13):8292-300. PMID: 19164298; PMCID: PMC2659187.
  115. Takamiya R, Hung CC, Hall SR, Fukunaga K, Nagaishi T, Maeno T, Owen C, Macias AA, Fredenburgh LE, Ishizaka A, Blumberg RS, Baron RM, Perrella MA. High-mobility group box 1 contributes to lethality of endotoxemia in heme oxygenase-1-deficient mice. Am J Respir Cell Mol Biol. 2009 Aug; 41(2):129-35. PMID: 19097991; PMCID: PMC2715902.
  116. Zhou D, Medoff BD, Chen L, Li L, Zhang XF, Praskova M, Liu M, Landry A, Blumberg RS, Boussiotis VA, Xavier R, Avruch J. The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naïve T cells. Proc Natl Acad Sci U S A. 2008 Dec 23; 105(51):20321-6. PMID: 19073936.
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  117. Kaser A, Blumberg RS. Paneth cells and inflammation dance together in Crohn's disease. Cell Res. 2008 Dec; 18(12):1160-2. PMID: 19043437; PMCID: PMC3990404.
  118. Strober W, Zeitz M, Blumberg RS. Mechanisms of intestinal inflammation. Preface. Mucosal Immunol. 2008 Nov; 1 Suppl 1:S1-4. PMID: 19079219.
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  119. Sauer KA, Maxeiner JH, Karwot R, Scholtes P, Lehr HA, Birkenbach M, Blumberg RS, Finotto S. Immunosurveillance of lung melanoma metastasis in EBI-3-deficient mice mediated by CD8+ T cells. J Immunol. 2008 Nov 01; 181(9):6148-57. PMID: 18941205; PMCID: PMC3996841.
  120. Nagaishi T, Chen Z, Chen L, Iijima H, Nakajima A, Blumberg RS. CEACAM1 and the regulation of mucosal inflammation. Mucosal Immunol. 2008 Nov; 1 Suppl 1:S39-42. PMID: 19079227; PMCID: PMC3901578.
  121. Blumberg R. What are innate and acquired immunity, and why are they important in IBD? Inflamm Bowel Dis. 2008 Oct; 14 Suppl 2:S93-4. PMID: 18816702.
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  122. Kaser A, Lee AH, Franke A, Glickman JN, Zeissig S, Tilg H, Nieuwenhuis EE, Higgins DE, Schreiber S, Glimcher LH, Blumberg RS. XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell. 2008 Sep 05; 134(5):743-56. PMID: 18775308; PMCID: PMC2586148.
  123. Kaser A, Hava DL, Dougan SK, Chen Z, Zeissig S, Brenner MB, Blumberg RS. Microsomal triglyceride transfer protein regulates endogenous and exogenous antigen presentation by group 1 CD1 molecules. Eur J Immunol. 2008 Aug; 38(8):2351-9. PMID: 18624350; PMCID: PMC4132950.
  124. Blumberg RS. Crohn disease. JAMA. 2008 Jul 23; 300(4):439-40. PMID: 18647989.
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  125. Qiao SW, Kobayashi K, Johansen FE, Sollid LM, Andersen JT, Milford E, Roopenian DC, Lencer WI, Blumberg RS. Dependence of antibody-mediated presentation of antigen on FcRn. Proc Natl Acad Sci U S A. 2008 Jul 08; 105(27):9337-42. PMID: 18599440; PMCID: PMC2453734.
  126. Kaser A, Blumberg RS. Adaptive immunity in inflammatory bowel disease: state of the art. Curr Opin Gastroenterol. 2008 Jul; 24(4):455-61. PMID: 18622159.
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  127. Blumberg RS, Li L, Nusrat A, Parkos CA, Rubin DC, Carrington JL. Recent insights into the integration of the intestinal epithelium within the mucosal environment in health and disease. Mucosal Immunol. 2008 Sep; 1(5):330-4. PMID: 19079196.
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  128. Tachibana M, Wada K, Katayama K, Kamisaki Y, Maeyama K, Kadowaki T, Blumberg RS, Nakajima A. Activation of peroxisome proliferator-activated receptor gamma suppresses mast cell maturation involved in allergic diseases. Allergy. 2008 Sep; 63(9):1136-47. PMID: 18547288; PMCID: PMC4023568.
  129. Chen Z, Chen L, Qiao SW, Nagaishi T, Blumberg RS. Carcinoembryonic antigen-related cell adhesion molecule 1 inhibits proximal TCR signaling by targeting ZAP-70. J Immunol. 2008 May 01; 180(9):6085-93. PMID: 18424730.
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  130. Fujisawa T, Nakajima A, Fujisawa N, Takahashi H, Ikeda I, Tomimoto A, Yonemitsu K, Nakajima N, Kudo C, Wada K, Kubota N, Terauchi Y, Kadowaki T, Nakagama H, Blumberg RS. Peroxisome proliferator-activated receptor gamma (PPARgamma) suppresses colonic epithelial cell turnover and colon carcinogenesis through inhibition of the beta-catenin/T cell factor (TCF) pathway. J Pharmacol Sci. 2008 Apr; 106(4):627-38. PMID: 18391483.
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  131. Sugimoto K, Ogawa A, Mizoguchi E, Shimomura Y, Andoh A, Bhan AK, Blumberg RS, Xavier RJ, Mizoguchi A. IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis. J Clin Invest. 2008 Feb; 118(2):534-44. PMID: 18172556; PMCID: PMC2157567.
  132. Masuda A, Yoshida M, Shiomi H, Ikezawa S, Takagawa T, Tanaka H, Chinzei R, Ishida T, Morita Y, Kutsumi H, Inokuchi H, Wang S, Kobayashi K, Mizuno S, Nakamura A, Takai T, Blumberg RS, Azuma T. Fcgamma receptor regulation of Citrobacter rodentium infection. Infect Immun. 2008 Apr; 76(4):1728-37. PMID: 18227164; PMCID: PMC2292883.
  133. Collison LW, Workman CJ, Kuo TT, Boyd K, Wang Y, Vignali KM, Cross R, Sehy D, Blumberg RS, Vignali DA. The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature. 2007 Nov 22; 450(7169):566-9. PMID: 18033300.
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  134. Dickinson BL, Claypool SM, D'Angelo JA, Aiken ML, Venu N, Yen EH, Wagner JS, Borawski JA, Pierce AT, Hershberg R, Blumberg RS, Lencer WI. Ca2+-dependent calmodulin binding to FcRn affects immunoglobulin G transport in the transcytotic pathway. Mol Biol Cell. 2008 Jan; 19(1):414-23. PMID: 18003977; PMCID: PMC2174181.
  135. Stern-Ginossar N, Nedvetzki S, Markel G, Gazit R, Betser-Cohen G, Achdout H, Aker M, Blumberg RS, Davis DM, Appelmelk B, Mandelboim O. Intercellular transfer of carcinoembryonic antigen from tumor cells to NK cells. J Immunol. 2007 Oct 01; 179(7):4424-34. PMID: 17878338.
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  136. van Dieren JM, van der Woude CJ, Kuipers EJ, Escher JC, Samsom JN, Blumberg RS, Nieuwenhuis EE. Roles of CD1d-restricted NKT cells in the intestine. Inflamm Bowel Dis. 2007 Sep; 13(9):1146-52. PMID: 17476670.
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  137. Zeissig S, Kaser A, Dougan SK, Nieuwenhuis EE, Blumberg RS. Role of NKT cells in the digestive system. III. Role of NKT cells in intestinal immunity. Am J Physiol Gastrointest Liver Physiol. 2007 Dec; 293(6):G1101-5. PMID: 17717040.
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  138. Kugathasan S, Saubermann LJ, Smith L, Kou D, Itoh J, Binion DG, Levine AD, Blumberg RS, Fiocchi C. Mucosal T-cell immunoregulation varies in early and late inflammatory bowel disease. Gut. 2007 Dec; 56(12):1696-705. PMID: 17682002; PMCID: PMC2095703.
  139. Hausding M, Karwot R, Scholtes P, Lehr HA, Wegmann M, Renz H, Galle PR, Birkenbach M, Neurath MF, Blumberg RS, Finotto S. Lung CD11c+ cells from mice deficient in Epstein-Barr virus-induced gene 3 (EBI-3) prevent airway hyper-responsiveness in experimental asthma. Eur J Immunol. 2007 Jun; 37(6):1663-77. PMID: 17506035.
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  140. Sartor RB, Blumberg RS, Braun J, Elson CO, Mayer LF. CCFA microbial-host interactions workshop: highlights and key observations. Inflamm Bowel Dis. 2007 May; 13(5):600-19. PMID: 17294437.
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  141. Perera L, Shao L, Patel A, Evans K, Meresse B, Blumberg R, Geraghty D, Groh V, Spies T, Jabri B, Mayer L. Expression of nonclassical class I molecules by intestinal epithelial cells. Inflamm Bowel Dis. 2007 Mar; 13(3):298-307. PMID: 17238179.
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  142. Mizoguchi A, Ogawa A, Takedatsu H, Sugimoto K, Shimomura Y, Shirane K, Nagahama K, Nagaishi T, Mizoguchi E, Blumberg RS, Bhan AK. Dependence of intestinal granuloma formation on unique myeloid DC-like cells. J Clin Invest. 2007 Mar; 117(3):605-15. PMID: 17318261; PMCID: PMC1797606.
  143. Dougan SK, Rava P, Hussain MM, Blumberg RS. MTP regulated by an alternate promoter is essential for NKT cell development. J Exp Med. 2007 Mar 19; 204(3):533-45. PMID: 17312007; PMCID: PMC2137905.
  144. Probert CS, Saubermann LJ, Balk S, Blumberg RS. Repertoire of the alpha beta T-cell receptor in the intestine. Immunol Rev. 2007 Feb; 215:215-25. PMID: 17291291.
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  145. Kawana K, Quayle AJ, Ficarra M, Ibana JA, Shen L, Kawana Y, Yang H, Marrero L, Yavagal S, Greene SJ, Zhang YX, Pyles RB, Blumberg RS, Schust DJ. CD1d degradation in Chlamydia trachomatis-infected epithelial cells is the result of both cellular and chlamydial proteasomal activity. J Biol Chem. 2007 Mar 09; 282(10):7368-75. PMID: 17215251.
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  146. Dougan SK, Kaser A, Blumberg RS. CD1 expression on antigen-presenting cells. Curr Top Microbiol Immunol. 2007; 314:113-41. PMID: 17593659.
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  147. Qiao SW, Lencer WI, Blumberg RS. How the controller is controlled - neonatal Fc receptor expression and immunoglobulin G homeostasis. Immunology. 2007 Feb; 120(2):145-7. PMID: 17140402; PMCID: PMC2265855.
  148. Bulwin GC, Heinemann T, Bugge V, Winter M, Lohan A, Schlawinsky M, Schulze A, Wälter S, Sabat R, Schülein R, Wiesner B, Veh RW, Löhler J, Blumberg RS, Volk HD, Utku N. TIRC7 inhibits T cell proliferation by modulation of CTLA-4 expression. J Immunol. 2006 Nov 15; 177(10):6833-41. PMID: 17082597.
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  149. Nagaishi T, Pao L, Lin SH, Iijima H, Kaser A, Qiao SW, Chen Z, Glickman J, Najjar SM, Nakajima A, Neel BG, Blumberg RS. SHP1 phosphatase-dependent T cell inhibition by CEACAM1 adhesion molecule isoforms. Immunity. 2006 Nov; 25(5):769-81. PMID: 17081782.
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  150. Markel G, Seidman R, Stern N, Cohen-Sinai T, Izhaki O, Katz G, Besser M, Treves AJ, Blumberg RS, Loewenthal R, Mandelboim O, Orenstein A, Schachter J. Inhibition of human tumor-infiltrating lymphocyte effector functions by the homophilic carcinoembryonic cell adhesion molecule 1 interactions. J Immunol. 2006 Nov 01; 177(9):6062-71. PMID: 17056532.
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  151. Yoshida M, Masuda A, Kuo TT, Kobayashi K, Claypool SM, Takagawa T, Kutsumi H, Azuma T, Lencer WI, Blumberg RS. IgG transport across mucosal barriers by neonatal Fc receptor for IgG and mucosal immunity. Springer Semin Immunopathol. 2006 Dec; 28(4):397-403. PMID: 17051393.
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  152. Nagaishi T, Iijima H, Nakajima A, Chen D, Blumberg RS. Role of CEACAM1 as a regulator of T cells. Ann N Y Acad Sci. 2006 Aug; 1072:155-75. PMID: 17057197.
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  153. Yoshida M, Kobayashi K, Kuo TT, Bry L, Glickman JN, Claypool SM, Kaser A, Nagaishi T, Higgins DE, Mizoguchi E, Wakatsuki Y, Roopenian DC, Mizoguchi A, Lencer WI, Blumberg RS. Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria. J Clin Invest. 2006 Aug; 116(8):2142-2151. PMID: 16841095; PMCID: PMC1501111.
  154. Wirtz S, Tubbe I, Galle PR, Schild HJ, Birkenbach M, Blumberg RS, Neurath MF. Protection from lethal septic peritonitis by neutralizing the biological function of interleukin 27. J Exp Med. 2006 Aug 07; 203(8):1875-81. PMID: 16880260; PMCID: PMC2118378.
  155. Gray-Owen SD, Blumberg RS. CEACAM1: contact-dependent control of immunity. Nat Rev Immunol. 2006 Jun; 6(6):433-46. PMID: 16724098.
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  156. Blumberg RS. Presentation of the Julius M. Friedenwald Medal to Norton J. Greenberger, MD. Gastroenterology. 2006 Jun; 130(7):2210-4. PMID: 16762642.
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  157. Utku N, Heinemann T, Winter M, Bulwin CG, Schlawinsky M, Fraser P, Nieuwenhuis EE, Volk HD, Blumberg RS. Antibody targeting of TIRC7 results in significant therapeutic effects on collagen-induced arthritis in mice. Clin Exp Immunol. 2006 Apr; 144(1):142-51. PMID: 16542376; PMCID: PMC1809623.
  158. Wada K, Nakajima A, Katayama K, Kudo C, Shibuya A, Kubota N, Terauchi Y, Tachibana M, Miyoshi H, Kamisaki Y, Mayumi T, Kadowaki T, Blumberg RS. Peroxisome proliferator-activated receptor gamma-mediated regulation of neural stem cell proliferation and differentiation. J Biol Chem. 2006 May 05; 281(18):12673-81. PMID: 16524877.
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  159. Brozovic S, Sahoo R, Barve S, Shiba H, Uriarte S, Blumberg RS, Kinane DF. Porphyromonas gingivalis enhances FasL expression via up-regulation of NFkappaB-mediated gene transcription and induces apoptotic cell death in human gingival epithelial cells. Microbiology. 2006 Mar; 152(Pt 3):797-806. PMID: 16514159.
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  160. Nieuwenhuis EE, Blumberg RS. The role of the epithelial barrier in inflammatory bowel disease. Adv Exp Med Biol. 2006; 579:108-16. PMID: 16620014.
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  161. Leav BA, Yoshida M, Rogers K, Cohen S, Godiwala N, Blumberg RS, Ward H. An early intestinal mucosal source of gamma interferon is associated with resistance to and control of Cryptosporidium parvum infection in mice. Infect Immun. 2005 Dec; 73(12):8425-8. PMID: 16299343; PMCID: PMC1307021.
  162. Furuta GT, Nieuwenhuis EE, Karhausen J, Gleich G, Blumberg RS, Lee JJ, Ackerman SJ. Eosinophils alter colonic epithelial barrier function: role for major basic protein. Am J Physiol Gastrointest Liver Physiol. 2005 Nov; 289(5):G890-7. PMID: 16227527.
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  163. Blumberg RS, Lencer WI. Antibodies in the breakdown lane. Nat Biotechnol. 2005 Oct; 23(10):1232-4. PMID: 16211062.
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  164. Dougan SK, Salas A, Rava P, Agyemang A, Kaser A, Morrison J, Khurana A, Kronenberg M, Johnson C, Exley M, Hussain MM, Blumberg RS. Microsomal triglyceride transfer protein lipidation and control of CD1d on antigen-presenting cells. J Exp Med. 2005 Aug 15; 202(4):529-39. PMID: 16087713; PMCID: PMC2212858.
  165. Zhu X, Peng J, Chen D, Liu X, Ye L, Iijima H, Kadavil K, Lencer WI, Blumberg RS. Calnexin and ERp57 facilitate the assembly of the neonatal Fc receptor for IgG with beta 2-microglobulin in the endoplasmic reticulum. J Immunol. 2005 Jul 15; 175(2):967-76. PMID: 16002696.
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  166. Tokuyama H, Ueha S, Kurachi M, Matsushima K, Moriyasu F, Blumberg RS, Kakimi K. The simultaneous blockade of chemokine receptors CCR2, CCR5 and CXCR3 by a non-peptide chemokine receptor antagonist protects mice from dextran sodium sulfate-mediated colitis. Int Immunol. 2005 Aug; 17(8):1023-34. PMID: 16000328.
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  167. Arita M, Yoshida M, Hong S, Tjonahen E, Glickman JN, Petasis NA, Blumberg RS, Serhan CN. Resolvin E1, an endogenous lipid mediator derived from omega-3 eicosapentaenoic acid, protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis. Proc Natl Acad Sci U S A. 2005 May 24; 102(21):7671-6. PMID: 15890784; PMCID: PMC1103706.
  168. Nieuwenhuis EE, Gillessen S, Scheper RJ, Exley MA, Taniguchi M, Balk SP, Strominger JL, Dranoff G, Blumberg RS, Wilson SB. CD1d and CD1d-restricted iNKT-cells play a pivotal role in contact hypersensitivity. Exp Dermatol. 2005 Apr; 14(4):250-8. PMID: 15810882.
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  169. Blumberg RS, Pitman RS, Taylor CT, Colgan SP. Cholera toxin potentiates influences of IFN-gamma through activation of NF-kappaB and release of tumor necrosis factor-alpha. J Interferon Cytokine Res. 2005 Apr; 25(4):209-19. PMID: 15812247.
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  170. Stirling CM, Charleston B, Takamatsu H, Claypool S, Lencer W, Blumberg RS, Wileman TE. Characterization of the porcine neonatal Fc receptor--potential use for trans-epithelial protein delivery. Immunology. 2005 Apr; 114(4):542-53. PMID: 15804291; PMCID: PMC1782108.
  171. Zahn S, Wirtz S, Birkenbach M, Blumberg RS, Neurath MF, von Stebut E. Impaired Th1 responses in mice deficient in Epstein-Barr virus-induced gene 3 and challenged with physiological doses of Leishmania major. Eur J Immunol. 2005 Apr; 35(4):1106-12. PMID: 15756639.
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  172. Wirtz S, Becker C, Fantini MC, Nieuwenhuis EE, Tubbe I, Galle PR, Schild HJ, Birkenbach M, Blumberg RS, Neurath MF. EBV-induced gene 3 transcription is induced by TLR signaling in primary dendritic cells via NF-kappa B activation. J Immunol. 2005 Mar 01; 174(5):2814-24. PMID: 15728491.
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  173. Lencer WI, Blumberg RS. A passionate kiss, then run: exocytosis and recycling of IgG by FcRn. Trends Cell Biol. 2005 Jan; 15(1):5-9. PMID: 15653072.
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  174. Yoneda M, Wada K, Katayama K, Nakajima N, Iwasaki T, Osawa E, Mukasa K, Yamada Y, Blumberg RS, Sekihara H, Nakajima A. A novel therapy for acute hepatitis utilizing dehydroepiandrosterone in the murine model of hepatitis. Biochem Pharmacol. 2004 Dec 01; 68(11):2283-9. PMID: 15498518.
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  175. Kaser A, Nieuwenhuis EE, Strober W, Mayer L, Fuss I, Colgan S, Blumberg RS. Natural killer T cells in mucosal homeostasis. Ann N Y Acad Sci. 2004 Dec; 1029:154-68. PMID: 15681754.
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  176. Markel G, Gruda R, Achdout H, Katz G, Nechama M, Blumberg RS, Kammerer R, Zimmermann W, Mandelboim O. The critical role of residues 43R and 44Q of carcinoembryonic antigen cell adhesion molecules-1 in the protection from killing by human NK cells. J Immunol. 2004 Sep 15; 173(6):3732-9. PMID: 15356119.
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  177. Anfossi N, Robbins SH, Ugolini S, Georgel P, Hoebe K, Bouneaud C, Ronet C, Kaser A, DiCioccio CB, Tomasello E, Blumberg RS, Beutler B, Reiner SL, Alexopoulou L, Lantz O, Raulet DH, Brossay L, Vivier E. Expansion and function of CD8+ T cells expressing Ly49 inhibitory receptors specific for MHC class I molecules. J Immunol. 2004 Sep 15; 173(6):3773-82. PMID: 15356124.
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  178. Utku N, Boerner A, Tomschegg A, Bennai-Sanfourche F, Bulwin GC, Heinemann T, Loehler J, Blumberg RS, Volk HD. TIRC7 deficiency causes in vitro and in vivo augmentation of T and B cell activation and cytokine response. J Immunol. 2004 Aug 15; 173(4):2342-52. PMID: 15294947.
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  179. Wada K, Nakajima A, Takahashi H, Yoneda M, Fujisawa N, Ohsawa E, Kadowaki T, Kubota N, Terauchi Y, Matsuhashi N, Saubermann LJ, Nakajima N, Blumberg RS. Protective effect of endogenous PPARgamma against acute gastric mucosal lesions associated with ischemia-reperfusion. Am J Physiol Gastrointest Liver Physiol. 2004 Aug; 287(2):G452-8. PMID: 15246971.
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  180. Markel G, Achdout H, Katz G, Ling KL, Salio M, Gruda R, Gazit R, Mizrahi S, Hanna J, Gonen-Gross T, Arnon TI, Lieberman N, Stren N, Nachmias B, Blumberg RS, Steuer G, Blau H, Cerundolo V, Mussaffi H, Mandelboim O. Biological function of the soluble CEACAM1 protein and implications in TAP2-deficient patients. Eur J Immunol. 2004 Aug; 34(8):2138-48. PMID: 15259011.
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  181. Bitonti AJ, Dumont JA, Low SC, Peters RT, Kropp KE, Palombella VJ, Stattel JM, Lu Y, Tan CA, Song JJ, Garcia AM, Simister NE, Spiekermann GM, Lencer WI, Blumberg RS. Pulmonary delivery of an erythropoietin Fc fusion protein in non-human primates through an immunoglobulin transport pathway. Proc Natl Acad Sci U S A. 2004 Jun 29; 101(26):9763-8. PMID: 15210944; PMCID: PMC470748.
  182. Kaser A, Blumberg RS. The other way round: colitis regulates regulatory T cells. Gastroenterology. 2004 Jun; 126(7):1903-6. PMID: 15188188.
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  183. Kaser A, Nieuwenhuis EE, Strober W, Fuss I, Colgan S, Blumberg RS. CD1d-restricted T cell pathways at the epithelial-lymphocyte-luminal interface. J Pediatr Gastroenterol Nutr. 2004 Jun; 39 Suppl 3:S719-22. PMID: 15167359.
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  184. Hokama A, Mizoguchi E, Sugimoto K, Shimomura Y, Tanaka Y, Yoshida M, Rietdijk ST, de Jong YP, Snapper SB, Terhorst C, Blumberg RS, Mizoguchi A. Induced reactivity of intestinal CD4(+) T cells with an epithelial cell lectin, galectin-4, contributes to exacerbation of intestinal inflammation. Immunity. 2004 Jun; 20(6):681-93. PMID: 15189734.
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  185. Yoshida M, Claypool SM, Wagner JS, Mizoguchi E, Mizoguchi A, Roopenian DC, Lencer WI, Blumberg RS. Human neonatal Fc receptor mediates transport of IgG into luminal secretions for delivery of antigens to mucosal dendritic cells. Immunity. 2004 Jun; 20(6):769-83. PMID: 15189741.
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  186. Fuss IJ, Heller F, Boirivant M, Leon F, Yoshida M, Fichtner-Feigl S, Yang Z, Exley M, Kitani A, Blumberg RS, Mannon P, Strober W. Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis. J Clin Invest. 2004 May; 113(10):1490-7. PMID: 15146247; PMCID: PMC406524.
  187. Brozovic S, Nagaishi T, Yoshida M, Betz S, Salas A, Chen D, Kaser A, Glickman J, Kuo T, Little A, Morrison J, Corazza N, Kim JY, Colgan SP, Young SG, Exley M, Blumberg RS. CD1d function is regulated by microsomal triglyceride transfer protein. Nat Med. 2004 May; 10(5):535-9. PMID: 15107843.
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  188. Kumamoto Y, Tomschegg A, Bennai-Sanfourche F, Boerner A, Kaser A, Schmidt-Knosalla I, Heinemann T, Schlawinsky M, Blumberg RS, Volk HD, Utku N. Monoclonal antibody specific for TIRC7 induces donor-specific anergy and prevents rejection of cardiac allografts in mice. Am J Transplant. 2004 Apr; 4(4):505-14. PMID: 15023142.
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  189. Chen D, Iijima H, Nagaishi T, Nakajima A, Russell S, Raychowdhury R, Morales V, Rudd CE, Utku N, Blumberg RS. Carcinoembryonic antigen-related cellular adhesion molecule 1 isoforms alternatively inhibit and costimulate human T cell function. J Immunol. 2004 Mar 15; 172(6):3535-43. PMID: 15004154.
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  190. Iijima H, Neurath MF, Nagaishi T, Glickman JN, Nieuwenhuis EE, Nakajima A, Chen D, Fuss IJ, Utku N, Lewicki DN, Becker C, Gallagher TM, Holmes KV, Blumberg RS. Specific regulation of T helper cell 1-mediated murine colitis by CEACAM1. J Exp Med. 2004 Feb 16; 199(4):471-82. PMID: 14970176; PMCID: PMC2211834.
  191. Claypool SM, Dickinson BL, Wagner JS, Johansen FE, Venu N, Borawski JA, Lencer WI, Blumberg RS. Bidirectional transepithelial IgG transport by a strongly polarized basolateral membrane Fcgamma-receptor. Mol Biol Cell. 2004 Apr; 15(4):1746-59. PMID: 14767057; PMCID: PMC379272.
  192. Matsumoto T, Nieuwenhuis EE, Cisneros RL, Ruiz-Perez B, Yamaguchi K, Blumberg RS, Onderdonk AB. Protective effect of ethyl-3-(3-dimethyl aminopropyl)urea dihydrochloride (EDU) against LPS-induced death in mice. J Med Microbiol. 2004 Feb; 53(Pt 2):97-102. PMID: 14729928.
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  193. Markel G, Mussaffi H, Ling KL, Salio M, Gadola S, Steuer G, Blau H, Achdout H, de Miguel M, Gonen-Gross T, Hanna J, Arnon TI, Qimron U, Volovitz I, Eisenbach L, Blumberg RS, Porgador A, Cerundolo V, Mandelboim O. The mechanisms controlling NK cell autoreactivity in TAP2-deficient patients. Blood. 2004 Mar 01; 103(5):1770-8. PMID: 14604968.
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  194. Colgan SP, Pitman RS, Nagaishi T, Mizoguchi A, Mizoguchi E, Mayer LF, Shao L, Sartor RB, Subjeck JR, Blumberg RS. Intestinal heat shock protein 110 regulates expression of CD1d on intestinal epithelial cells. J Clin Invest. 2003 Sep; 112(5):745-54. PMID: 12952923; PMCID: PMC182184.
  195. Gillessen S, Naumov YN, Nieuwenhuis EE, Exley MA, Lee FS, Mach N, Luster AD, Blumberg RS, Taniguchi M, Balk SP, Strominger JL, Dranoff G, Wilson SB. CD1d-restricted T cells regulate dendritic cell function and antitumor immunity in a granulocyte-macrophage colony-stimulating factor-dependent fashion. Proc Natl Acad Sci U S A. 2003 Jul 22; 100(15):8874-9. PMID: 12847287; PMCID: PMC166406.
  196. Katayama K, Wada K, Nakajima A, Mizuguchi H, Hayakawa T, Nakagawa S, Kadowaki T, Nagai R, Kamisaki Y, Blumberg RS, Mayumi T. A novel PPAR gamma gene therapy to control inflammation associated with inflammatory bowel disease in a murine model. Gastroenterology. 2003 May; 124(5):1315-24. PMID: 12730872.
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  197. van de Wal Y, Corazza N, Allez M, Mayer LF, Iijima H, Ryan M, Cornwall S, Kaiserlian D, Hershberg R, Koezuka Y, Colgan SP, Blumberg RS. Delineation of a CD1d-restricted antigen presentation pathway associated with human and mouse intestinal epithelial cells. Gastroenterology. 2003 May; 124(5):1420-31. PMID: 12730881.
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  198. Tiede I, Fritz G, Strand S, Poppe D, Dvorsky R, Strand D, Lehr HA, Wirtz S, Becker C, Atreya R, Mudter J, Hildner K, Bartsch B, Holtmann M, Blumberg R, Walczak H, Iven H, Galle PR, Ahmadian MR, Neurath MF. CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes. J Clin Invest. 2003 Apr; 111(8):1133-45. PMID: 12697733; PMCID: PMC152932.
  199. Shah U, Dickinson BL, Blumberg RS, Simister NE, Lencer WI, Walker WA. Distribution of the IgG Fc receptor, FcRn, in the human fetal intestine. Pediatr Res. 2003 Feb; 53(2):295-301. PMID: 12538789; PMCID: PMC2819091.
  200. Nieuwenhuis EE, Neurath MF, Corazza N, Iijima H, Trgovcich J, Wirtz S, Glickman J, Bailey D, Yoshida M, Galle PR, Kronenberg M, Birkenbach M, Blumberg RS. Disruption of T helper 2-immune responses in Epstein-Barr virus-induced gene 3-deficient mice. Proc Natl Acad Sci U S A. 2002 Dec 24; 99(26):16951-6. PMID: 12482940; PMCID: PMC139250.
  201. Heller F, Fuss IJ, Nieuwenhuis EE, Blumberg RS, Strober W. Oxazolone colitis, a Th2 colitis model resembling ulcerative colitis, is mediated by IL-13-producing NK-T cells. Immunity. 2002 Nov; 17(5):629-38. PMID: 12433369.
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  202. Zhu X, Peng J, Raychowdhury R, Nakajima A, Lencer WI, Blumberg RS. The heavy chain of neonatal Fc receptor for IgG is sequestered in endoplasmic reticulum by forming oligomers in the absence of beta2-microglobulin association. Biochem J. 2002 Nov 01; 367(Pt 3):703-14. PMID: 12162790; PMCID: PMC1222943.
  203. Perez A, Grikscheit TC, Blumberg RS, Ashley SW, Vacanti JP, Whang EE. Tissue-engineered small intestine: ontogeny of the immune system. Transplantation. 2002 Sep 15; 74(5):619-23. PMID: 12352876.
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  204. Saubermann LJ, Nakajima A, Wada K, Zhao S, Terauchi Y, Kadowaki T, Aburatani H, Matsuhashi N, Nagai R, Blumberg RS. Peroxisome proliferator-activated receptor gamma agonist ligands stimulate a Th2 cytokine response and prevent acute colitis. Inflamm Bowel Dis. 2002 Sep; 8(5):330-9. PMID: 12479648.
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  205. Spiekermann GM, Finn PW, Ward ES, Dumont J, Dickinson BL, Blumberg RS, Lencer WI. Receptor-mediated immunoglobulin G transport across mucosal barriers in adult life: functional expression of FcRn in the mammalian lung. J Exp Med. 2002 Aug 05; 196(3):303-10. PMID: 12163559; PMCID: PMC2193935.
  206. Nieuwenhuis EE, Matsumoto T, Exley M, Schleipman RA, Glickman J, Bailey DT, Corazza N, Colgan SP, Onderdonk AB, Blumberg RS. CD1d-dependent macrophage-mediated clearance of Pseudomonas aeruginosa from lung. Nat Med. 2002 Jun; 8(6):588-93. PMID: 12042809.
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  207. Claypool SM, Dickinson BL, Yoshida M, Lencer WI, Blumberg RS. Functional reconstitution of human FcRn in Madin-Darby canine kidney cells requires co-expressed human beta 2-microglobulin. J Biol Chem. 2002 Aug 02; 277(31):28038-50. PMID: 12023961; PMCID: PMC2825174.
  208. Neurath MF, Weigmann B, Finotto S, Glickman J, Nieuwenhuis E, Iijima H, Mizoguchi A, Mizoguchi E, Mudter J, Galle PR, Bhan A, Autschbach F, Sullivan BM, Szabo SJ, Glimcher LH, Blumberg RS. The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease. J Exp Med. 2002 May 06; 195(9):1129-43. PMID: 11994418; PMCID: PMC2193714.
  209. Markel G, Lieberman N, Katz G, Arnon TI, Lotem M, Drize O, Blumberg RS, Bar-Haim E, Mader R, Eisenbach L, Mandelboim O. CD66a interactions between human melanoma and NK cells: a novel class I MHC-independent inhibitory mechanism of cytotoxicity. J Immunol. 2002 Mar 15; 168(6):2803-10. PMID: 11884449.
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  210. Mizoguchi A, Mizoguchi E, Takedatsu H, Blumberg RS, Bhan AK. Chronic intestinal inflammatory condition generates IL-10-producing regulatory B cell subset characterized by CD1d upregulation. Immunity. 2002 Feb; 16(2):219-30. PMID: 11869683.
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  211. Nakajima A, Iijima H, Neurath MF, Nagaishi T, Nieuwenhuis EE, Raychowdhury R, Glickman J, Blau DM, Russell S, Holmes KV, Blumberg RS. Activation-induced expression of carcinoembryonic antigen-cell adhesion molecule 1 regulates mouse T lymphocyte function. J Immunol. 2002 Feb 01; 168(3):1028-35. PMID: 11801635.
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  212. Wirtz S, Becker C, Blumberg R, Galle PR, Neurath MF. Treatment of T cell-dependent experimental colitis in SCID mice by local administration of an adenovirus expressing IL-18 antisense mRNA. J Immunol. 2002 Jan 01; 168(1):411-20. PMID: 11751987.
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  213. Strober W, Fuss IJ, Blumberg RS. The immunology of mucosal models of inflammation. Annu Rev Immunol. 2002; 20:495-549. PMID: 11861611.
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  214. Watt SM, Teixeira AM, Zhou GQ, Doyonnas R, Zhang Y, Grunert F, Blumberg RS, Kuroki M, Skubitz KM, Bates PA. Homophilic adhesion of human CEACAM1 involves N-terminal domain interactions: structural analysis of the binding site. Blood. 2001 Sep 01; 98(5):1469-79. PMID: 11520797.
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  215. Omata F, Birkenbach M, Matsuzaki S, Christ AD, Blumberg RS. The expression of IL-12 p40 and its homologue, Epstein-Barr virus-induced gene 3, in inflammatory bowel disease. Inflamm Bowel Dis. 2001 Aug; 7(3):215-20. PMID: 11515847.
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  216. Wada K, Nakajima A, Blumberg RS. PPARgamma and inflammatory bowel disease: a new therapeutic target for ulcerative colitis and Crohn's disease. Trends Mol Med. 2001 Aug; 7(8):329-31. PMID: 11516972.
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  217. Blumberg RS, van de Wal Y, Claypool S, Corazza N, Dickinson B, Nieuwenhuis E, Pitman R, Spiekermann G, Zhu X, Colgan S, Lencer WI. The multiple roles of major histocompatibility complex class-I-like molecules in mucosal immune function. Acta Odontol Scand. 2001 Jun; 59(3):139-44. PMID: 11501882; PMCID: PMC2824335.
  218. Blumberg RS. Characterization of CD1d in mucosal immune function: an immunotherapeutic target for inflammatory bowel disease. Keio J Med. 2001 Mar; 50(1):39-44. PMID: 11296664.
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  219. Probert CS, Chott A, Saubermann LJ, Stevens AC, Balk SP, Blumberg RS. Prevalence of an ulcerative colitis-associated CD8+ T cell receptor beta-chain CDR3-region motif and its association with disease activity. J Clin Immunol. 2001 Mar; 21(2):126-34. PMID: 11332651.
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  220. Zhu X, Meng G, Dickinson BL, Li X, Mizoguchi E, Miao L, Wang Y, Robert C, Wu B, Smith PD, Lencer WI, Blumberg RS. MHC class I-related neonatal Fc receptor for IgG is functionally expressed in monocytes, intestinal macrophages, and dendritic cells. J Immunol. 2001 Mar 01; 166(5):3266-76. PMID: 11207281; PMCID: PMC2827247.
  221. Blumberg RS, Strober W. Prospects for research in inflammatory bowel disease. JAMA. 2001 Feb 07; 285(5):643-7. PMID: 11176874.
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  222. Nakajima A, Wada K, Miki H, Kubota N, Nakajima N, Terauchi Y, Ohnishi S, Saubermann LJ, Kadowaki T, Blumberg RS, Nagai R, Matsuhashi N. Endogenous PPAR gamma mediates anti-inflammatory activity in murine ischemia-reperfusion injury. Gastroenterology. 2001 Feb; 120(2):460-9. PMID: 11159886.
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  223. Roberts AI, Blumberg RS, Christ AD, Brolin RE, Ebert EC. Staphylococcal enterotoxin B induces potent cytotoxic activity by intraepithelial lymphocytes. Immunology. 2000 Oct; 101(2):185-90. PMID: 11012771; PMCID: PMC2327067.
  224. Kim HS, Colgan SP, Pitman R, Hershberg RM, Blumberg RS. Human CD1d associates with prolyl-4-hydroxylase during its biosynthesis. Mol Immunol. 2000 Oct; 37(14):861-8. PMID: 11257307.
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  225. Mizoguchi A, Mizoguchi E, Saubermann LJ, Higaki K, Blumberg RS, Bhan AK. Limited CD4 T-cell diversity associated with colitis in T-cell receptor alpha mutant mice requires a T helper 2 environment. Gastroenterology. 2000 Oct; 119(4):983-95. PMID: 11040185.
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  226. Blumberg RS. David and Goliath: discovery in the industrial age of science. Gastroenterology. 2000 Jul; 119(1):5. PMID: 10889148.
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  227. Saubermann LJ, Beck P, De Jong YP, Pitman RS, Ryan MS, Kim HS, Exley M, Snapper S, Balk SP, Hagen SJ, Kanauchi O, Motoki K, Sakai T, Terhorst C, Koezuka Y, Podolsky DK, Blumberg RS. Activation of natural killer T cells by alpha-galactosylceramide in the presence of CD1d provides protection against colitis in mice. Gastroenterology. 2000 Jul; 119(1):119-28. PMID: 10889161.
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  228. Wei Y, Mrsny RJ, Blumberg RS, Fried M, Christ AD. Choice of microcentrifuge tubes influences T cell proliferation assay. Biotechniques. 2000 Jul; 29(1):54-6, 59. PMID: 10907077.
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  229. Badizadegan K, Dickinson BL, Wheeler HE, Blumberg RS, Holmes RK, Lencer WI. Heterogeneity of detergent-insoluble membranes from human intestine containing caveolin-1 and ganglioside G(M1). Am J Physiol Gastrointest Liver Physiol. 2000 Jun; 278(6):G895-904. PMID: 10859219; PMCID: PMC2827257.
  230. Exley M, Garcia J, Wilson SB, Spada F, Gerdes D, Tahir SM, Patton KT, Blumberg RS, Porcelli S, Chott A, Balk SP. CD1d structure and regulation on human thymocytes, peripheral blood T cells, B cells and monocytes. Immunology. 2000 May; 100(1):37-47. PMID: 10809957; PMCID: PMC2326993.
  231. Muehlhoefer A, Saubermann LJ, Gu X, Luedtke-Heckenkamp K, Xavier R, Blumberg RS, Podolsky DK, MacDermott RP, Reinecker HC. Fractalkine is an epithelial and endothelial cell-derived chemoattractant for intraepithelial lymphocytes in the small intestinal mucosa. J Immunol. 2000 Mar 15; 164(6):3368-76. PMID: 10706732.
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  232. Pitman RS, Blumberg RS. First line of defense: the role of the intestinal epithelium as an active component of the mucosal immune system. J Gastroenterol. 2000; 35(11):805-14. PMID: 11085489.
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  233. Blumberg RS, Saubermann LJ, Strober W. Animal models of mucosal inflammation and their relation to human inflammatory bowel disease. Curr Opin Immunol. 1999 Dec; 11(6):648-56. PMID: 10631550.
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  234. Colgan SP, Hershberg RM, Furuta GT, Blumberg RS. Ligation of intestinal epithelial CD1d induces bioactive IL-10: critical role of the cytoplasmic tail in autocrine signaling. Proc Natl Acad Sci U S A. 1999 Nov 23; 96(24):13938-43. PMID: 10570177; PMCID: PMC24169.
  235. Dickinson BL, Badizadegan K, Wu Z, Ahouse JC, Zhu X, Simister NE, Blumberg RS, Lencer WI. Bidirectional FcRn-dependent IgG transport in a polarized human intestinal epithelial cell line. J Clin Invest. 1999 Oct; 104(7):903-11. PMID: 10510331; PMCID: PMC408555.
  236. Campbell NA, Kim HS, Blumberg RS, Mayer L. The nonclassical class I molecule CD1d associates with the novel CD8 ligand gp180 on intestinal epithelial cells. J Biol Chem. 1999 Sep 10; 274(37):26259-65. PMID: 10473580.
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  237. Hershberg RM, Blumberg RS. What's so (Co)stimulating about the intestinal epithelium? Gastroenterology. 1999 Sep; 117(3):726-8. PMID: 10464150.
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  238. Morales VM, Christ A, Watt SM, Kim HS, Johnson KW, Utku N, Texieira AM, Mizoguchi A, Mizoguchi E, Russell GJ, Russell SE, Bhan AK, Freeman GJ, Blumberg RS. Regulation of human intestinal intraepithelial lymphocyte cytolytic function by biliary glycoprotein (CD66a). J Immunol. 1999 Aug 01; 163(3):1363-70. PMID: 10415036.
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  239. Blumberg RS, Lencer WI, Zhu X, Kim HS, Claypool S, Balk SP, Saubermann LJ, Colgan SP. Antigen presentation by intestinal epithelial cells. Immunol Lett. 1999 Jun 15; 69(1):7-11. PMID: 10436875.
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  240. Kim HS, Garcia J, Exley M, Johnson KW, Balk SP, Blumberg RS. Biochemical characterization of CD1d expression in the absence of beta2-microglobulin. J Biol Chem. 1999 Apr 02; 274(14):9289-95. PMID: 10092605.
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  241. Blumberg RS. The leadership of innovation. Gastroenterology. 1999 Apr; 116(4):787. PMID: 10206783.
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  242. Somnay-Wadgaonkar K, Nusrat A, Kim HS, Canchis WP, Balk SP, Colgan SP, Blumberg RS. Immunolocalization of CD1d in human intestinal epithelial cells and identification of a beta2-microglobulin-associated form. Int Immunol. 1999 Mar; 11(3):383-92. PMID: 10221650.
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  243. Saubermann LJ, Probert CS, Christ AD, Chott A, Turner JR, Stevens AC, Balk SP, Blumberg RS. Evidence of T cell receptor beta-chain patterns in inflammatory and noninflammatory bowel disease states. Am J Physiol. 1999 Mar; 276(3 Pt 1):G613-21. PMID: 10070037.
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  244. Panczak A, Hirsch F, Hagerty D, Blumberg R, Poncet P. A signalling accessory molecule revealed by a new anti-fibroblastoid L cell monoclonal antibody. Folia Biol (Praha). 1999; 45(3):101-14. PMID: 10730898.
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  245. Baiden-Amissah K, Joashi U, Blumberg R, Mehmet H, Edwards AD, Cox PM. Expression of amyloid precursor protein (beta-APP) in the neonatal brain following hypoxic ischaemic injury. Neuropathol Appl Neurobiol. 1998 Oct; 24(5):346-52. PMID: 9821164.
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  246. Utku N, Heinemann T, Tullius SG, Bulwin GC, Beinke S, Blumberg RS, Beato F, Randall J, Kojima R, Busconi L, Robertson ES, Schülein R, Volk HD, Milford EL, Gullans SR. Prevention of acute allograft rejection by antibody targeting of TIRC7, a novel T cell membrane protein. Immunity. 1998 Oct; 9(4):509-18. PMID: 9806637.
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  247. Anumanthan A, Bensussan A, Boumsell L, Christ AD, Blumberg RS, Voss SD, Patel AT, Robertson MJ, Nadler LM, Freeman GJ. Cloning of BY55, a novel Ig superfamily member expressed on NK cells, CTL, and intestinal intraepithelial lymphocytes. J Immunol. 1998 Sep 15; 161(6):2780-90. PMID: 9743336.
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  248. Christ AD, Stevens AC, Koeppen H, Walsh S, Omata F, Devergne O, Birkenbach M, Blumberg RS. An interleukin 12-related cytokine is up-regulated in ulcerative colitis but not in Crohn's disease. Gastroenterology. 1998 Aug; 115(2):307-13. PMID: 9679036.
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  249. Blumberg RS. Current concepts in mucosal immunity. II. One size fits all: nonclassical MHC molecules fulfill multiple roles in epithelial cell function. Am J Physiol. 1998 Feb; 274(2 Pt 1):G227-31. PMID: 9486173.
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  250. Probert CS, Aitken EW, Saubermann LJ, Balk SP, Blumberg RS. T-cell receptor usage in the intestine. Chem Immunol. 1998; 71:27-39. PMID: 9761945.
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  251. Israel EJ, Taylor S, Wu Z, Mizoguchi E, Blumberg RS, Bhan A, Simister NE. Expression of the neonatal Fc receptor, FcRn, on human intestinal epithelial cells. Immunology. 1997 Sep; 92(1):69-74. PMID: 9370926; PMCID: PMC1363983.
  252. Koningsberger JC, Chott A, Logtenberg T, Wiegman LJ, Blumberg RS, van Berge Henegouwen GP, Balk SP. TCR expression in human fetal intestine and identification of an early T cell receptor beta-chain transcript. J Immunol. 1997 Aug 15; 159(4):1775-82. PMID: 9257840.
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  253. Chott A, Gerdes D, Spooner A, Mosberger I, Kummer JA, Ebert EC, Blumberg RS, Balk SP. Intraepithelial lymphocytes in normal human intestine do not express proteins associated with cytolytic function. Am J Pathol. 1997 Aug; 151(2):435-42. PMID: 9250156; PMCID: PMC1858008.
  254. Christ AD, Colgan SP, Balk SP, Blumberg RS. Human intestinal epithelial cell lines produce factor(s) that inhibit CD3-mediated T-lymphocyte proliferation. Immunol Lett. 1997 Aug; 58(3):159-65. PMID: 9293397.
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  255. Blumberg RS, Colgan SP, Balk SP. CD1d: outside-in antigen presentation in the intestinal epithelium? Clin Exp Immunol. 1997 Aug; 109(2):223-5. PMID: 9276515; PMCID: PMC1904737.
  256. Probert CS, Christ AD, Saubermann LJ, Turner JR, Chott A, Carr-Locke D, Balk SP, Blumberg RS. Analysis of human common bile duct-associated T cells: evidence for oligoclonality, T cell clonal persistence, and epithelial cell recognition. J Immunol. 1997 Feb 15; 158(4):1941-8. PMID: 9029136.
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  257. Christ AD, Blumberg RS. The intestinal epithelial cell: immunological aspects. Springer Semin Immunopathol. 1997; 18(4):449-61. PMID: 9144864.
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  258. Probert CS, Chott A, Turner JR, Saubermann LJ, Stevens AC, Bodinaku K, Elson CO, Balk SP, Blumberg RS. Persistent clonal expansions of peripheral blood CD4+ lymphocytes in chronic inflammatory bowel disease. J Immunol. 1996 Oct 01; 157(7):3183-91. PMID: 8816432.
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  259. Colgan SP, Morales VM, Madara JL, Polischuk JE, Balk SP, Blumberg RS. IFN-gamma modulates CD1d surface expression on intestinal epithelia. Am J Physiol. 1996 Jul; 271(1 Pt 1):C276-83. PMID: 8760056.
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  260. Chott A, Probert CS, Gross GG, Blumberg RS, Balk SP. A common TCR beta-chain expressed by CD8+ intestinal mucosa T cells in ulcerative colitis. J Immunol. 1996 Apr 15; 156(8):3024-35. PMID: 8609425.
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  261. Taplin ME, Frantz ME, Canning C, Ritz J, Blumberg RS, Balk SP. Evidence against T-cell development in the adult human intestinal mucosa based upon lack of terminal deoxynucleotidyltransferase expression. Immunology. 1996 Mar; 87(3):402-7. PMID: 8778025; PMCID: PMC1384108.
  262. Landau SB, Probert CS, Stevens CA, Balk SP, Blumberg RS. Over-utilization of the J delta 3 gene-segment in Crohn's disease. J Clin Lab Immunol. 1996; 48(1):33-44. PMID: 10332632.
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  263. Kim HS, Morales VM, Dass C, Encinas J, Teitell M, Blumberg RS. Cloning of the gene encoding the mouse homologue of the human calcium signal-modulating ligand. Gene. 1995 Oct 03; 163(2):323-4. PMID: 7590290.
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  264. Blumberg RS, Gerdes D, Chott A, Porcelli SA, Balk SP. Structure and function of the CD1 family of MHC-like cell surface proteins. Immunol Rev. 1995 Oct; 147:5-29. PMID: 8847079.
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  265. Balk SP, Polischuk JE, Probert C, Stevens C, Ebert E, She J, Terhorst C, Blumberg RS. Composition of TCR-CD3 complex in human intestinal intraepithelial lymphocytes: lack of Fc epsilon RI gamma chain. Int Immunol. 1995 Aug; 7(8):1237-41. PMID: 7495730.
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  266. Michie CA, Blumberg R. Group B streptococcal infection: when does vertical transmission take place? Arch Dis Child Fetal Neonatal Ed. 1995 Jul; 73(1):F46-7. PMID: 7552598; PMCID: PMC2528364.
  267. Blumberg RS, Koss T, Story CM, Barisani D, Polischuk J, Lipin A, Pablo L, Green R, Simister NE. A major histocompatibility complex class I-related Fc receptor for IgG on rat hepatocytes. J Clin Invest. 1995 May; 95(5):2397-402. PMID: 7738203; PMCID: PMC295868.
  268. Blumberg RS. An antigen shared by colon, eye, and joint and relevance for ulcerative colitis. Inflamm Bowel Dis. 1995; 1(1):88-9. PMID: 23283314.
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  269. Brandeis JM, Sayegh MH, Gallon L, Blumberg RS, Carpenter CB. Rat intestinal epithelial cells present major histocompatibility complex allopeptides to primed T cells. Gastroenterology. 1994 Nov; 107(5):1537-42. PMID: 7926518.
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  270. Gross GG, Schwartz VL, Stevens C, Ebert EC, Blumberg RS, Balk SP. Distribution of dominant T cell receptor beta chains in human intestinal mucosa. J Exp Med. 1994 Oct 01; 180(4):1337-44. PMID: 7931067; PMCID: PMC2191673.
  271. Balk SP, Burke S, Polischuk JE, Frantz ME, Yang L, Porcelli S, Colgan SP, Blumberg RS. Beta 2-microglobulin-independent MHC class Ib molecule expressed by human intestinal epithelium. Science. 1994 Jul 08; 265(5169):259-62. PMID: 7517575.
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  272. Blumberg RS, Balk SP. Intraepithelial lymphocytes and their recognition of non-classical MHC molecules. Int Rev Immunol. 1994; 11(1):15-30. PMID: 7520051.
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  273. Canchis PW, Bhan AK, Landau SB, Yang L, Balk SP, Blumberg RS. Tissue distribution of the non-polymorphic major histocompatibility complex class I-like molecule, CD1d. Immunology. 1993 Dec; 80(4):561-5. PMID: 7508419; PMCID: PMC1422252.
  274. Panja A, Blumberg RS, Balk SP, Mayer L. CD1d is involved in T cell-intestinal epithelial cell interactions. J Exp Med. 1993 Sep 01; 178(3):1115-9. PMID: 7688787; PMCID: PMC2191181.
  275. Blumberg RS, Yockey CE, Gross GG, Ebert EC, Balk SP. Human intestinal intraepithelial lymphocytes are derived from a limited number of T cell clones that utilize multiple V beta T cell receptor genes. J Immunol. 1993 Jun 01; 150(11):5144-53. PMID: 8496608.
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  276. Blumberg RS, Terhorst C, Bleicher P, McDermott FV, Allan CH, Landau SB, Trier JS, Balk SP. Expression of a nonpolymorphic MHC class I-like molecule, CD1D, by human intestinal epithelial cells. J Immunol. 1991 Oct 15; 147(8):2518-24. PMID: 1717564.
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  277. Balk SP, Ebert EC, Blumenthal RL, McDermott FV, Wucherpfennig KW, Landau SB, Blumberg RS. Oligoclonal expansion and CD1 recognition by human intestinal intraepithelial lymphocytes. Science. 1991 Sep 20; 253(5026):1411-5. PMID: 1716785.
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  278. Alarcón B, Ley SC, Sánchez-Madrid F, Blumberg RS, Ju ST, Fresno M, Terhorst C. The CD3-gamma and CD3-delta subunits of the T cell antigen receptor can be expressed within distinct functional TCR/CD3 complexes. EMBO J. 1991 Apr; 10(4):903-12. PMID: 1826255; PMCID: PMC452733.
  279. Blumberg RS, Sancho J, Ley SC, McDermott FV, Tan KN, Breitmeyer J, Terhorst C. Genetic reconstitution of the T cell receptor (TcR) alpha/beta heterodimer restores the association of CD3 zeta 2 with the TcR/CD3 complex. Eur J Immunol. 1991 Feb; 21(2):473-81. PMID: 1825637.
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  280. Bleicher PA, Balk SP, Hagen SJ, Blumberg RS, Flotte TJ, Terhorst C. Expression of murine CD1 on gastrointestinal epithelium. Science. 1990 Nov 02; 250(4981):679-82. PMID: 1700477.
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  281. Blumberg RS, Ley S, Sancho J, Lonberg N, Lacy E, McDermott F, Schad V, Greenstein JL, Terhorst C. Structure of the T-cell antigen receptor: evidence for two CD3 epsilon subunits in the T-cell receptor-CD3 complex. Proc Natl Acad Sci U S A. 1990 Sep; 87(18):7220-4. PMID: 2144901; PMCID: PMC54715.
  282. Blumberg RS, Alarcon B, Sancho J, McDermott FV, Lopez P, Breitmeyer J, Terhorst C. Assembly and function of the T cell antigen receptor. Requirement of either the lysine or arginine residues in the transmembrane region of the alpha chain. J Biol Chem. 1990 Aug 15; 265(23):14036-43. PMID: 2143190.
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  283. Reno TA, Ley S, Sugiyama E, Cantagrel A, Blumberg R, Bonventre J, Terhorst C, Yeh ET. Defects in signal transduction caused by a T cell receptor beta chain substitution. Eur J Immunol. 1990 Jul; 20(7):1417-22. PMID: 1696890.
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  284. Blumberg RS. Relapse of chronic inflammatory bowel disease. 'A riddle wrapped in a mystery inside an enigma'. Gastroenterology. 1990 Mar; 98(3):792-6. PMID: 2404829.
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  285. Sancho J, Chatila T, Wong RC, Hall C, Blumberg R, Alarcon B, Geha RS, Terhorst C. T-cell antigen receptor (TCR)-alpha/beta heterodimer formation is a prerequisite for association of CD3-zeta 2 into functionally competent TCR.CD3 complexes. J Biol Chem. 1989 Dec 05; 264(34):20760-9. PMID: 2531145.
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  286. Picard MH, Dennis C, Schwartz RG, Ahn DK, Kraemer HC, Berger WE, Blumberg R, Heller R, Lew H, DeBusk RF. Cost-benefit analysis of early return to work after uncomplicated acute myocardial infarction. Am J Cardiol. 1989 Jun 01; 63(18):1308-14. PMID: 2499172.
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  287. Blumberg RS, Chopra S, Ibrahim R, Crawford J, Farraye FA, Zeldis JB, Berman MD. Primary hepatocellular carcinoma in idiopathic hemochromatosis after reversal of cirrhosis. Gastroenterology. 1988 Nov; 95(5):1399-402. PMID: 2844622.
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  288. Blumberg RS, Paradis T, Hartshorn KL, Vogt M, Ho DD, Hirsch MS, Leban J, Sato VL, Schooley RT. Antibody-dependent cell-mediated cytotoxicity against cells infected with the human immunodeficiency virus. J Infect Dis. 1987 Dec; 156(6):878-84. PMID: 3479500.
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  289. Blumberg RS, Hartshorn KL, Ardman B, Kaplan JC, Paradis T, Vogt M, Hirsch MS, Schooley RT. Dot immunobinding assay for detection of human immunodeficiency virus-associated antigens. J Clin Microbiol. 1987 Oct; 25(10):1989-92. PMID: 3312291; PMCID: PMC269383.
  290. Walker BD, Chakrabarti S, Moss B, Paradis TJ, Flynn T, Durno AG, Blumberg RS, Kaplan JC, Hirsch MS, Schooley RT. HIV-specific cytotoxic T lymphocytes in seropositive individuals. Nature. 1987 Jul 23-29; 328(6128):345-8. PMID: 3496541.
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  291. Blumberg RS, Paradis T, Byington R, Henle W, Hirsch MS, Schooley RT. Effects of human immunodeficiency virus on the cellular immune response to Epstein-Barr virus in homosexual men: characterization of the cytotoxic response and lymphokine production. J Infect Dis. 1987 May; 155(5):877-90. PMID: 3031170.
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  292. Hartshorn KL, Vogt MW, Chou TC, Blumberg RS, Byington R, Schooley RT, Hirsch MS. Synergistic inhibition of human immunodeficiency virus in vitro by azidothymidine and recombinant alpha A interferon. Antimicrob Agents Chemother. 1987 Feb; 31(2):168-72. PMID: 3471180; PMCID: PMC174685.
  293. Blumberg RS, Paradis TJ, Crawford D, Byington RE, Hirsch MS, Schooley RT. Effects of human immunodeficiency virus (HIV) on the cytotoxic response to Epstein Barr virus (EBV) transformed B lymphocytes. AIDS Res Hum Retroviruses. 1987; 3(3):303-15. PMID: 2829951.
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  294. Schooley RT, Blumberg RS, Vogt M, Hartshorn K, Hirsch MS. Therapeutic perspectives in human immunodeficiency virus infection. J Exp Pathol. 1987; 3(4):661-80. PMID: 3331652.
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  295. Blumberg RS, Sandstrom EG, Paradis TJ, Neumeyer DN, Sarngadharan MG, Hartshorn KL, Byington RE, Hirsch MS, Schooley RT. Detection of human T-cell lymphotropic virus type III-related antigens and anti-human T-cell lymphotropic virus type III antibodies by anticomplementary immunofluorescence. J Clin Microbiol. 1986 Jun; 23(6):1072-7. PMID: 2423552; PMCID: PMC268796.
  296. Kurnick JT, Kradin RL, Blumberg R, Schneeberger EE, Boyle LA. Functional characterization of T lymphocytes propagated from human lung carcinomas. Clin Immunol Immunopathol. 1986 Mar; 38(3):367-80. PMID: 3080265.
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  297. Blumberg RS, Schooley RT. Lymphocyte markers and infectious diseases. Semin Hematol. 1985 Apr; 22(2):81-114. PMID: 2988132.
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  298. Blumberg RS, Kelsey P, Perrone T, Dickersin R, Laquaglia M, Ferruci J. Cytomegalovirus- and Cryptosporidium-associated acalculous gangrenous cholecystitis. Am J Med. 1984 Jun; 76(6):1118-23. PMID: 6328993.
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  299. Weniger BG, Blumberg RS, Campbell CC, Jones TC, Mount DL, Friedman SM. High-level chloroquine resistance of Plasmodium falciparum malaria acquired in Kenya. N Engl J Med. 1982 Dec 16; 307(25):1560-2. PMID: 6755252.
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  300. Borchardt KA, Sullivan RW, Blumberg RS, Gelber RH, Botch V, Crull S, Ullyot DJ. Erysipelothrix rhusiopathiae endocarditis. West J Med. 1977 Aug; 127(2):149-51. PMID: 561483; PMCID: PMC1237739.
  301. BORIS M, BLUMBERG R, FELDMAN DB, SELLERS TF. Increased incidence of meningomyeloceles. JAMA. 1963 Jun 06; 184:768. PMID: 14013971.
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  302. NAHMIAS A, SAKURAI N, BLUMBERG R, DOE GE A, SULZER C. The Staphylococcus "80/81 complex: epidemiological and laboratory observations. J Infect Dis. 1961 Nov-Dec; 109:211-22. PMID: 14477984.
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