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profileWilliam Samuel David, M.D.,PH.D.

TitleAssociate Professor of Neurology
InstitutionMassachusetts General Hospital
DepartmentNeurology
AddressMassachusetts General Hospital
Neurology, Suite 820
165 Cambridge St.
Boston MA 02114
Phone617/726-2066
Fax617/726-2019
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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. David WS, Bowley MP, Mehan WA, Shin JH, Gerstner ER, DeWitt JC. Case 19-2017 - A 53-Year-Old Woman with Leg Numbness and Weakness. N Engl J Med. 2017 Jun 22; 376(25):2471-2481. PMID: 28636859.
    View in: PubMed
  2. Scholz J, Rathmell JP, David WS, Chad DA, Broderick AC, Perros SG, Shin NS, Wells JL, Davis JB, DiMaggio CJ, Wang S, Tate SN. A standardized clinical evaluation of phenotypic diversity in diabetic polyneuropathy. Pain. 2016 Oct; 157(10):2297-308. PMID: 27322439.
    View in: PubMed
  3. Pasnoor M, He J, Herbelin L, Burns TM, Nations S, Bril V, Wang AK, Elsheikh BH, Kissel JT, Saperstein D, Shaibani JA, Jackson C, Swenson A, Howard JF, Goyal N, David W, Wicklund M, Pulley M, Becker M, Mozaffar T, Benatar M, Pazcuzzi R, Simpson E, Rosenfeld J, Dimachkie MM, Statland JM, Barohn RJ. A randomized controlled trial of methotrexate for patients with generalized myasthenia gravis. Neurology. 2016 Jul 05; 87(1):57-64. PMID: 27306628; PMCID: PMC4932232 [Available on 07/05/17].
  4. Burns TM, Smith GA, Allen JA, Amato AA, Arnold WD, Barohn R, Benatar M, Bird SJ, Bromberg M, Chahin N, Ciafaloni E, Cohen JA, Corse A, Crum BA, David WS, Dimberg E, Sousa EA, Donofrio PD, Dyck PJ, Engel AG, Ensrud ER, Ferrante M, Freimer M, Gable KL, Gibson S, Gilchrist JM, Goldstein JM, Gooch CL, Goodman BP, Gorelov D, Gospe SM, Goyal NA, Guidon AC, Guptill JT, Gutmann L, Gutmann L, Gwathmey K, Harati Y, Harper CM, Hehir MK, Hobson-Webb LD, Howard JF, Jackson CE, Johnson N, Jones SM, Juel VC, Kaminski HJ, Karam C, Kennelly KD, Khella S, Khoury J, Kincaid JC, Kissel JT, Kolb N, Lacomis D, Ladha S, Larriviere D, Lewis RA, Li Y, Litchy WJ, Logigian E, Lou JS, MacGowen DJ, Maselli R, Massey JM, Mauermann ML, Mathews KD, Meriggioli MN, Miller RG, Moon JS, Mozaffar T, Nations SP, Nowak RJ, Ostrow LW, Pascuzzi RM, Peltier A, Ruzhansky K, Richman DP, Ross MA, Rubin DI, Russell JA, Sachs GM, Salajegheh MK, Saperstein DS, Scelsa S, Selcen D, Shaibani A, Shieh PB, Silvestri NJ, Singleton JR, Smith BE, So YT, Solorzano G, Sorenson EJ, Srinivasen J, Tavee J, Tawil R, Thaisetthawatkul P, Thornton C, Trivedi J, Vernino S, Wang AK, Webb TA, Weiss MD, Windebank AJ, Wolfe GI. Editorial by concerned physicians: Unintended effect of the orphan drug act on the potential cost of 3,4-diaminopyridine. Muscle Nerve. 2016 Feb; 53(2):165-8. PMID: 26662952.
    View in: PubMed
  5. David WS, Chad DA. Neuromuscular Disorders. Semin Neurol. 2015 Aug; 35(4):325. PMID: 26502756.
    View in: PubMed
  6. Narayanaswami P, Dubinsky R, Wang D, Gjorvad G, David W, Finder J, Smith B, Cheng J, Shapiro F, Mellion M, Spurney C, Wolff J, England J. Quality improvement in neurology: muscular dystrophy quality measures. Neurology. 2015 Sep 08; 85(10):905-9. PMID: 26333798; PMCID: PMC4560061.
  7. David WS. Case 3-2015: A woman with abdominal pain, dyspnea, and diplopia. N Engl J Med. 2015 Apr 23; 372(17):1675. PMID: 25901441.
    View in: PubMed
  8. Fridman V, Oaklander AL, David WS, Johnson EA, Pan J, Novak P, Brown RH, Eichler FS. Natural history and biomarkers in hereditary sensory neuropathy type 1. Muscle Nerve. 2015 Apr; 51(4):489-95. PMID: 25042817; PMCID: PMC4484799.
  9. David WS, Temin ES, Kraeft JJ, Hooper DC. Case records of the Massachusetts General Hospital. Case 3-2015. A 60-year-old woman with abdominal pain, dyspnea, and diplopia. N Engl J Med. 2015 Jan 22; 372(4):364-72. PMID: 25607430.
    View in: PubMed
  10. Amato AA, Sivakumar K, Goyal N, David WS, Salajegheh M, Praestgaard J, Lach-Trifilieff E, Trendelenburg AU, Laurent D, Glass DJ, Roubenoff R, Tseng BS, Greenberg SA. Treatment of sporadic inclusion body myositis with bimagrumab. Neurology. 2014 Dec 09; 83(24):2239-46. PMID: 25381300; PMCID: PMC4277670 [Available on 12/09/15].
  11. Narayanaswami P, Weiss M, Selcen D, David W, Raynor E, Carter G, Wicklund M, Barohn RJ, Ensrud E, Griggs RC, Gronseth G, Amato AA. Evidence-based guideline summary: diagnosis and treatment of limb-girdle and distal dystrophies: report of the guideline development subcommittee of the American Academy of Neurology and the practice issues review panel of the American Association of Neuromuscular & Electrodiagnostic Medicine. Neurology. 2014 Oct 14; 83(16):1453-63. PMID: 25313375; PMCID: PMC4206155.
  12. Zhao Y, Cudkowicz ME, Shefner JM, Krivickas L, David WS, Vriesendorp F, Pestronk A, Caress JB, Katz J, Simpson E, Rosenfeld J, Pascuzzi R, Glass J, Rezania K, Harmatz JS, Schoenfeld D, Greenblatt DJ. Systemic pharmacokinetics and cerebrospinal fluid uptake of intravenous ceftriaxone in patients with amyotrophic lateral sclerosis. J Clin Pharmacol. 2014 Oct; 54(10):1180-7. PMID: 24771634; PMCID: PMC4352577.
  13. England JD, Franklin G, Gjorvad G, Swain-Eng R, Brannagan TH, David WS, Dubinsky RM, Smith BE. Quality improvement in neurology: Distal symmetric polyneuropathy quality measures. Neurology. 2014 May 13; 82(19):1745-8. PMID: 24696504; PMCID: PMC4032209.
  14. Rutkove SB, Caress JB, Cartwright MS, Burns TM, Warder J, David WS, Goyal N, Maragakis NJ, Benatar M, Sharma KR, Narayanaswami P, Raynor EM, Watson ML, Shefner JM. Electrical impedance myography correlates with standard measures of ALS severity. Muscle Nerve. 2014 Mar; 49(3):441-3. PMID: 24273034.
    View in: PubMed
  15. Berry JD, Shefner JM, Conwit R, Schoenfeld D, Keroack M, Felsenstein D, Krivickas L, David WS, Vriesendorp F, Pestronk A, Caress JB, Katz J, Simpson E, Rosenfeld J, Pascuzzi R, Glass J, Rezania K, Rothstein JD, Greenblatt DJ, Cudkowicz ME. Design and initial results of a multi-phase randomized trial of ceftriaxone in amyotrophic lateral sclerosis. PLoS One. 2013; 8(4):e61177. PMID: 23613806; PMCID: PMC3629222.
  16. Karam C, Quinn CC, Paganoni S, David WS. Teaching NeuroImages: Ganglion cyst causing pure sensory ulnar neuropathy at the wrist. Neurology. 2012 Aug 21; 79(8):e76. PMID: 22915183.
    View in: PubMed
  17. Rutkove SB, Caress JB, Cartwright MS, Burns TM, Warder J, David WS, Goyal N, Maragakis NJ, Clawson L, Benatar M, Usher S, Sharma KR, Gautam S, Narayanaswami P, Raynor EM, Watson ML, Shefner JM. Electrical impedance myography as a biomarker to assess ALS progression. Amyotroph Lateral Scler. 2012 Sep; 13(5):439-45. PMID: 22670883; PMCID: PMC3422377.
  18. Fridman V, David WS. Electrodiagnostic evaluation of lower extremity mononeuropathies. Neurol Clin. 2012 May; 30(2):505-28. PMID: 22361372.
    View in: PubMed
  19. David WS, Chad DA, Kambadakone A, Hedley-Whyte ET. Case records of the Massachusetts General Hospital. Case 7-2012. A 79-year-old man with pain and weakness in the legs. N Engl J Med. 2012 Mar 08; 366(10):944-54. PMID: 22397657.
    View in: PubMed
  20. Saboisky JP, Stashuk DW, Hamilton-Wright A, Carusona AL, Campana LM, Trinder J, Eckert DJ, Jordan AS, McSharry DG, White DP, Nandedkar S, David WS, Malhotra A. Neurogenic changes in the upper airway of patients with obstructive sleep apnea. Am J Respir Crit Care Med. 2012 Feb 01; 185(3):322-9. PMID: 22016445; PMCID: PMC3297112.
  21. Shefner JM, Watson ML, Simionescu L, Caress JB, Burns TM, Maragakis NJ, Benatar M, David WS, Sharma KR, Rutkove SB. Multipoint incremental motor unit number estimation as an outcome measure in ALS. Neurology. 2011 Jul 19; 77(3):235-41. PMID: 21676915; PMCID: PMC3136054.
  22. David WS, Goyal N, Henry FP, Baldassari LE, Redmond RW. Validation of an incremental motor unit number estimation technique in rabbits. Muscle Nerve. 2010 Jun; 41(6):794-9. PMID: 20169589.
    View in: PubMed
  23. Goyal N, Salameh JS, Baldassari LE, David WS. Added sampling improves reproducibility of multipoint motor unit estimates. Muscle Nerve. 2010 Jan; 41(1):114-6. PMID: 19813198.
    View in: PubMed
  24. Salameh JS, Atassi N, David WS. SOD1 (A4V)-mediated ALS presenting with lower motor neuron facial diplegia and unilateral vocal cord paralysis. Muscle Nerve. 2009 Nov; 40(5):880-2. PMID: 19618436.
    View in: PubMed
  25. Salameh JS, Shenoy AM, David WS. Novel SPG3A and SPG4 mutations in two patients with Silver syndrome. J Clin Neuromuscul Dis. 2009 Sep; 11(1):57-9. PMID: 19730024.
    View in: PubMed
  26. Henry FP, Goyal NA, David WS, Wes D, Bujold KE, Randolph MA, Winograd JM, Kochevar IE, Redmond RW. Improving electrophysiologic and histologic outcomes by photochemically sealing amnion to the peripheral nerve repair site. Surgery. 2009 Mar; 145(3):313-21. PMID: 19231584.
    View in: PubMed
  27. Sorenson EJ, Windbank AJ, Mandrekar JN, Bamlet WR, Appel SH, Armon C, Barkhaus PE, Bosch P, Boylan K, David WS, Feldman E, Glass J, Gutmann L, Katz J, King W, Luciano CA, McCluskey LF, Nash S, Newman DS, Pascuzzi RM, Pioro E, Sams LJ, Scelsa S, Simpson EP, Subramony SH, Tiryaki E, Thornton CA. Subcutaneous IGF-1 is not beneficial in 2-year ALS trial. Neurology. 2008 Nov 25; 71(22):1770-5. PMID: 19029516; PMCID: PMC2617770.
  28. Kesler SM, Sprenkle MD, David WS, Leatherman JW. Severe weakness complicating status asthmaticus despite minimal duration of neuromuscular paralysis. Intensive Care Med. 2009 Jan; 35(1):157-60. PMID: 18807012.
    View in: PubMed
  29. Simmons Z, Felgoise SH, Bremer BA, Walsh SM, Hufford DJ, Bromberg MB, David W, Forshew DA, Heiman-Patterson TD, Lai EC, McCluskey L. The ALSSQOL: balancing physical and nonphysical factors in assessing quality of life in ALS. Neurology. 2006 Nov 14; 67(9):1659-64. PMID: 17101900.
    View in: PubMed
  30. Lange DJ, Lechtzin N, Davey C, David W, Heiman-Patterson T, Gelinas D, Becker B, Mitsumoto H. High-frequency chest wall oscillation in ALS: an exploratory randomized, controlled trial. Neurology. 2006 Sep 26; 67(6):991-7. PMID: 17000967.
    View in: PubMed
  31. Kang PB, Lidov HG, David WS, Torres A, Anthony DC, Jones HR, Darras BT. Diagnostic value of electromyography and muscle biopsy in arthrogryposis multiplex congenita. Ann Neurol. 2003 Dec; 54(6):790-5. PMID: 14681888.
    View in: PubMed
  32. Cudkowicz ME, Shefner JM, Schoenfeld DA, Brown RH, Johnson H, Qureshi M, Jacobs M, Rothstein JD, Appel SH, Pascuzzi RM, Heiman-Patterson TD, Donofrio PD, David WS, Russell JA, Tandan R, Pioro EP, Felice KJ, Rosenfeld J, Mandler RN, Sachs GM, Bradley WG, Raynor EM, Baquis GD, Belsh JM, Novella S, Goldstein J, Hulihan J. A randomized, placebo-controlled trial of topiramate in amyotrophic lateral sclerosis. Neurology. 2003 Aug 26; 61(4):456-64. PMID: 12939417.
    View in: PubMed
  33. David WS, Chaudhry V, Dubin AH, Shields RW. Literature review: nervepace digital electroneurometer in the diagnosis of carpal tunnel syndrome. Muscle Nerve. 2003 Mar; 27(3):378-85. PMID: 12635127.
    View in: PubMed
  34. David WS. Myoglobinuria. Neurol Clin. 2000 Feb; 18(1):215-43. PMID: 10658177.
    View in: PubMed
  35. David WS, Mahdavi Z, Nance M, Khan M. Hyperlipidemia and neuropathy. Electromyogr Clin Neurophysiol. 1999 Jun; 39(4):227-30. PMID: 10394507.
    View in: PubMed
  36. David WS, Roehr CL, Leatherman JW. EMG findings in acute myopathy with status asthmaticus, steroids and paralytics. Clinical and electrophysiologic correlation. Electromyogr Clin Neurophysiol. 1998 Sep; 38(6):371-6. PMID: 9783124.
    View in: PubMed
  37. David WS, Sharif AA. Clozapine-induced myokymia. Muscle Nerve. 1998 Jun; 21(6):827-8. PMID: 9585344.
    View in: PubMed
  38. Nance MA, Raabe WA, Midani H, Kolodny EH, David WS, Megna L, Pericak-Vance MA, Haines JL. Clinical heterogeneity of familial spastic paraplegia linked to chromosome 2p21. Hum Hered. 1998 May-Jun; 48(3):169-78. PMID: 9618065.
    View in: PubMed
  39. David WS, Bundlie SR, Mahdavi Z. Polysomnographic studies in amyotrophic lateral sclerosis. J Neurol Sci. 1997 Oct; 152 Suppl 1:S29-35. PMID: 9419051.
    View in: PubMed
  40. David WS, Doyle JJ. Acute infantile weakness: a case of vaccine-associated poliomyelitis. Muscle Nerve. 1997 Jun; 20(6):747-9. PMID: 9149084.
    View in: PubMed
  41. David WS, Peine C, Schlesinger P, Smith SA. Nonsystemic vasculitic mononeuropathy multiplex, cryoglobulinemia, and hepatitis C. Muscle Nerve. 1996 Dec; 19(12):1596-602. PMID: 8941274.
    View in: PubMed
  42. Roth CR, Glaze LE, Goding GS, David WS. Spasmodic dysphonia symptoms as initial presentation of amyotrophic lateral sclerosis. J Voice. 1996 Dec; 10(4):362-7. PMID: 8943140.
    View in: PubMed
  43. Leatherman JW, Fluegel WL, David WS, Davies SF, Iber C. Muscle weakness in mechanically ventilated patients with severe asthma. Am J Respir Crit Care Med. 1996 May; 153(5):1686-90. PMID: 8630621.
    View in: PubMed
  44. David WS, Jones HR. Soft tissue sarcoma presenting as atypical extremity pain. Muscle Nerve. 1994 Sep; 17(9):1071-2. PMID: 8065397.
    View in: PubMed
  45. David WS, Jones HR. Electromyography and biopsy correlation with suggested protocol for evaluation of the floppy infant. Muscle Nerve. 1994 Apr; 17(4):424-30. PMID: 8170489.
    View in: PubMed
  46. Doyle JJ, David WS. Posterior antebrachial cutaneous neuropathy associated with lateral elbow pain. Muscle Nerve. 1993 Dec; 16(12):1417-8. PMID: 8232403.
    View in: PubMed
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