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Adrian Salic, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01GM135262 (SALIC, ADRIAN) Sep 1, 2020 - May 31, 2024
    Transducing Hedgehog signals across the plasma membrane
    Role: Principal Investigator
  2. R01GM122920 (SALIC, ADRIAN) May 1, 2018 - Feb 28, 2022
    Sending and receiving Hedgehog signals
    Role: Principal Investigator
  3. R01GM110041 (SALIC, ADRIAN) May 1, 2014 - Feb 28, 2018
    Novel mechanisms for oxysterols in cell-cell signaling
    Role: Principal Investigator
  4. R01GM092924 (SALIC, ADRIAN) Aug 1, 2011 - Jun 30, 2016
    Mechanisms of Vertebrate Hedgehog Signaling
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. de Almeida Magalhães T, Alencastro Veiga Cruzeiro G, Ribeiro de Sousa G, Englinger B, Peinado Nagano LF, Ancliffe M, Rodrigues da Silva K, Jiang L, Gojo J, Cherry Liu Y, Carline B, Kuchibhotla M, Pinto Saggioro F, Kazue Nagahashi Marie S, Mieko Oba-Shinjo S, Andres Yunes J, Gomes de Paula Queiroz R, Alberto Scrideli C, Endersby R, Filbin MG, Silva Borges K, Salic A, Gonzaga Tone L, Terci Valera E. Activation of Hedgehog signaling by the oncogenic RELA fusion reveals a primary cilia-dependent vulnerability in Supratentorial Ependymoma. Neuro Oncol. 2022 May 31. PMID: 35640920.
    Citations:    Fields:    
  2. Liu YC, Wierbowski BM, Salic A. Hedgehog pathway modulation by glypican 3-conjugated heparan sulfate. J Cell Sci. 2022 03 15; 135(6). PMID: 35142364; PMCID: PMC8977055.
    Citations:    Fields:    Translation:HumansCells
  3. Huang P, Wierbowski BM, Lian T, Chan C, García-Linares S, Jiang J, Salic A. Structural basis for catalyzed assembly of the Sonic hedgehog-Patched1 signaling complex. Dev Cell. 2022 03 14; 57(5):670-685.e8. PMID: 35231446; PMCID: PMC8932645.
    Citations:    Fields:    Translation:Cells
  4. Li W, Wang L, Wierbowski BM, Lu M, Dong F, Liu W, Li S, Wang P, Salic A, Gong X. Structural insights into proteolytic activation of the human Dispatched1 transporter for Hedgehog morphogen release. Nat Commun. 2021 11 29; 12(1):6966. PMID: 34845226; PMCID: PMC8630017.
    Citations: 1     Fields:    Translation:HumansCells
  5. Petrov K, de Almeida Magalhaes T, Salic A. Mechanism and ultrasensitivity in Hedgehog signaling revealed by Patched1 disease mutations. Proc Natl Acad Sci U S A. 2021 02 09; 118(6). PMID: 33526656.
    Citations: 5     Fields:    Translation:AnimalsCells
  6. Wierbowski BM, Petrov K, Aravena L, Gu G, Xu Y, Salic A. Hedgehog Pathway Activation Requires Coreceptor-Catalyzed, Lipid-Dependent Relay of the Sonic Hedgehog Ligand. Dev Cell. 2020 11 23; 55(4):450-467.e8. PMID: 33038332.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  7. Petrov K, Wierbowski BM, Liu J, Salic A. Distinct Cation Gradients Power Cholesterol Transport at Different Key Points in the Hedgehog Signaling Pathway. Dev Cell. 2020 11 09; 55(3):314-327.e7. PMID: 32860743.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  8. Huang P, Zheng S, Wierbowski BM, Kim Y, Nedelcu D, Aravena L, Liu J, Kruse AC, Salic A. Structural Basis of Smoothened Activation in Hedgehog Signaling. Cell. 2018 09 20; 175(1):295-297. PMID: 30241610.
    Citations: 15     Fields:    
  9. Huang P, Zheng S, Wierbowski BM, Kim Y, Nedelcu D, Aravena L, Liu J, Kruse AC, Salic A. Structural Basis of Smoothened Activation in Hedgehog Signaling. Cell. 2018 07 12; 174(2):312-324.e16. PMID: 29804838.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  10. Petrov K, Wierbowski BM, Salic A. Sending and Receiving Hedgehog Signals. Annu Rev Cell Dev Biol. 2017 10 06; 33:145-168. PMID: 28693388.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  11. Tukachinsky H, Petrov K, Watanabe M, Salic A. Mechanism of inhibition of the tumor suppressor Patched by Sonic Hedgehog. Proc Natl Acad Sci U S A. 2016 10 04; 113(40):E5866-E5875. PMID: 27647915; PMCID: PMC5056095.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  12. Huang P, Nedelcu D, Watanabe M, Jao C, Kim Y, Liu J, Salic A. Cellular Cholesterol Directly Activates Smoothened in Hedgehog Signaling. Cell. 2016 Aug 25; 166(5):1176-1187.e14. PMID: 27545348.
    Citations: 149     Fields:    Translation:AnimalsCells
  13. Broadus MR, Chen TW, Neitzel LR, Ng VH, Jodoin JN, Lee LA, Salic A, Robbins DJ, Capobianco AJ, Patton JG, Huppert SS, Lee E. Identification of a Paralog-Specific Notch1 Intracellular Domain Degron. Cell Rep. 2016 05 31; 15(9):1920-9. PMID: 27210761.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  14. Clima L, Peptanariu D, Pinteala M, Salic A, Barboiu M. DyNAvectors: dynamic constitutional vectors for adaptive DNA transfection. Chem Commun (Camb). 2015 Dec 25; 51(99):17529-31. PMID: 26469153.
    Citations: 4     Fields:    Translation:HumansCells
  15. Turin-Moleavin IA, Doroftei F, Coroaba A, Peptanariu D, Pinteala M, Salic A, Barboiu M. Dynamic constitutional frameworks (DCFs) as nanovectors for cellular delivery of DNA. Org Biomol Chem. 2015 Sep 14; 13(34):9005-11. PMID: 26171592.
    Citations: 4     Fields:    Translation:HumansCells
  16. Jao CY, Nedelcu D, Lopez LV, Samarakoon TN, Welti R, Salic A. Bioorthogonal probes for imaging sterols in cells. Chembiochem. 2015 Mar 02; 16(4):611-7. PMID: 25663046.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  17. Jao CY, Roth M, Welti R, Salic A. Biosynthetic labeling and two-color imaging of phospholipids in cells. Chembiochem. 2015 Feb 09; 16(3):472-6. PMID: 25586136.
    Citations: 12     Fields:    Translation:AnimalsCells
  18. Iyoshi S, Cheng J, Tatematsu T, Takatori S, Taki M, Yamamoto Y, Salic A, Fujimoto T. Asymmetrical distribution of choline phospholipids revealed by click chemistry and freeze-fracture electron microscopy. ACS Chem Biol. 2014 Oct 17; 9(10):2217-22. PMID: 25122546.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  19. Signer RA, Magee JA, Salic A, Morrison SJ. Haematopoietic stem cells require a highly regulated protein synthesis rate. Nature. 2014 May 01; 509(7498):49-54. PMID: 24670665; PMCID: PMC4015626.
    Citations: 250     Fields:    Translation:AnimalsCells
  20. Nedelcu D, Liu J, Xu Y, Jao C, Salic A. Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling. Nat Chem Biol. 2013 Sep; 9(9):557-64. PMID: 23831757.
    Citations: 87     Fields:    Translation:AnimalsCells
  21. Tukachinsky H, Kuzmickas RP, Jao CY, Liu J, Salic A. Dispatched and scube mediate the efficient secretion of the cholesterol-modified hedgehog ligand. Cell Rep. 2012 Aug 30; 2(2):308-20. PMID: 22902404; PMCID: PMC3682496.
    Citations: 92     Fields:    Translation:HumansAnimalsCells
  22. Liu J, Xu Y, Stoleru D, Salic A. Imaging protein synthesis in cells and tissues with an alkyne analog of puromycin. Proc Natl Acad Sci U S A. 2012 Jan 10; 109(2):413-8. PMID: 22160674.
    Citations: 161     Fields:    Translation:Cells
  23. Thorne CA, Lafleur B, Lewis M, Hanson AJ, Jernigan KK, Weaver DC, Huppert KA, Chen TW, Wichaidit C, Cselenyi CS, Tahinci E, Meyers KC, Waskow E, Orton D, Salic A, Lee LA, Robbins DJ, Huppert SS, Lee E. A biochemical screen for identification of small-molecule regulators of the Wnt pathway using Xenopus egg extracts. J Biomol Screen. 2011 Oct; 16(9):995-1006. PMID: 21859680.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  24. Chen X, Tukachinsky H, Huang CH, Jao C, Chu YR, Tang HY, Mueller B, Schulman S, Rapoport TA, Salic A. Processing and turnover of the Hedgehog protein in the endoplasmic reticulum. J Cell Biol. 2011 Mar 07; 192(5):825-38. PMID: 21357747.
    Citations: 69     Fields:    Translation:HumansAnimalsCells
  25. Tukachinsky H, Lopez LV, Salic A. A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu-Gli protein complexes. J Cell Biol. 2010 Oct 18; 191(2):415-28. PMID: 20956384.
    Citations: 216     Fields:    Translation:AnimalsCells
  26. Thorne CA, Hanson AJ, Schneider J, Tahinci E, Orton D, Cselenyi CS, Jernigan KK, Meyers KC, Hang BI, Waterson AG, Kim K, Melancon B, Ghidu VP, Sulikowski GA, LaFleur B, Salic A, Lee LA, Miller DM, Lee E. Small-molecule inhibition of Wnt signaling through activation of casein kinase 1a. Nat Chem Biol. 2010 Nov; 6(11):829-36. PMID: 20890287.
    Citations: 230     Fields:    Translation:HumansAnimalsCells
  27. Jao CY, Roth M, Welti R, Salic A. Metabolic labeling and direct imaging of choline phospholipids in vivo. Proc Natl Acad Sci U S A. 2009 Sep 08; 106(36):15332-7. PMID: 19706413.
    Citations: 77     Fields:    Translation:HumansAnimalsCells
  28. Jao CY, Salic A. Exploring RNA transcription and turnover in vivo by using click chemistry. Proc Natl Acad Sci U S A. 2008 Oct 14; 105(41):15779-84. PMID: 18840688; PMCID: PMC2572917.
    Citations: 267     Fields:    Translation:AnimalsCells
  29. Wühr M, Chen Y, Dumont S, Groen AC, Needleman DJ, Salic A, Mitchison TJ. Evidence for an upper limit to mitotic spindle length. Curr Biol. 2008 Aug 26; 18(16):1256-61. PMID: 18718761.
    Citations: 106     Fields:    Translation:AnimalsCells
  30. Buck SB, Bradford J, Gee KR, Agnew BJ, Clarke ST, Salic A. Detection of S-phase cell cycle progression using 5-ethynyl-2'-deoxyuridine incorporation with click chemistry, an alternative to using 5-bromo-2'-deoxyuridine antibodies. Biotechniques. 2008 Jun; 44(7):927-9. PMID: 18533904.
    Citations: 114     Fields:    Translation:HumansCells
  31. Salic A, Mitchison TJ. A chemical method for fast and sensitive detection of DNA synthesis in vivo. Proc Natl Acad Sci U S A. 2008 Feb 19; 105(7):2415-20. PMID: 18272492.
    Citations: 751     Fields:    Translation:AnimalsCells
  32. Tahinci E, Thorne CA, Franklin JL, Salic A, Christian KM, Lee LA, Coffey RJ, Lee E. Lrp6 is required for convergent extension during Xenopus gastrulation. Development. 2007 Nov; 134(22):4095-106. PMID: 17965054.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  33. Boyarchuk Y, Salic A, Dasso M, Arnaoutov A. Bub1 is essential for assembly of the functional inner centromere. J Cell Biol. 2007 Mar 26; 176(7):919-28. PMID: 17389228; PMCID: PMC2064078.
    Citations: 60     Fields:    Translation:HumansAnimalsCells
  34. Salic A, King RW. Identifying small molecule inhibitors of the ubiquitin-proteasome pathway in Xenopus egg extracts. Methods Enzymol. 2005; 399:567-85. PMID: 16338382.
    Citations: 7     Fields:    Translation:AnimalsCells
  35. Salic A, Waters JC, Mitchison TJ. Vertebrate shugoshin links sister centromere cohesion and kinetochore microtubule stability in mitosis. Cell. 2004 Sep 03; 118(5):567-78. PMID: 15339662.
    Citations: 136     Fields:    Translation:AnimalsCells
  36. Sampath SC, Ohi R, Leismann O, Salic A, Pozniakovski A, Funabiki H. The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly. Cell. 2004 Jul 23; 118(2):187-202. PMID: 15260989.
    Citations: 211     Fields:    Translation:HumansAnimalsCells
  37. Lee E, Salic A, Krüger R, Heinrich R, Kirschner MW. The roles of APC and Axin derived from experimental and theoretical analysis of the Wnt pathway. PLoS Biol. 2003 Oct; 1(1):E10. PMID: 14551908; PMCID: PMC212691.
    Citations: 274     Fields:    Translation:AnimalsCells
  38. Lowe CJ, Wu M, Salic A, Evans L, Lander E, Stange-Thomann N, Gruber CE, Gerhart J, Kirschner M. Anteroposterior patterning in hemichordates and the origins of the chordate nervous system. Cell. 2003 Jun 27; 113(7):853-65. PMID: 12837244.
    Citations: 138     Fields:    Translation:Animals
  39. Stein PA, Toret CP, Salic AN, Rolls MM, Rapoport TA. A novel centrosome-associated protein with affinity for microtubules. J Cell Sci. 2002 Sep 01; 115(Pt 17):3389-402. PMID: 12154070.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  40. Holmen SL, Salic A, Zylstra CR, Kirschner MW, Williams BO. A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate beta -catenin-dependent signaling. J Biol Chem. 2002 Sep 20; 277(38):34727-35. PMID: 12121999.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  41. Lee E, Salic A, Kirschner MW. Physiological regulation of [beta]-catenin stability by Tcf3 and CK1epsilon. J Cell Biol. 2001 Sep 03; 154(5):983-93. PMID: 11524435; PMCID: PMC2196183.
    Citations: 59     Fields:    Translation:AnimalsCells
  42. Pfleger CM, Salic A, Lee E, Kirschner MW. Inhibition of Cdh1-APC by the MAD2-related protein MAD2L2: a novel mechanism for regulating Cdh1. Genes Dev. 2001 Jul 15; 15(14):1759-64. PMID: 11459825; PMCID: PMC312740.
    Citations: 54     Fields:    Translation:AnimalsCells
  43. Ivan M, Kondo K, Yang H, Kim W, Valiando J, Ohh M, Salic A, Asara JM, Lane WS, Kaelin WG. HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science. 2001 Apr 20; 292(5516):464-8. PMID: 11292862.
    Citations: 1591     Fields:    Translation:HumansAnimalsCells
  44. Salic A, Lee E, Mayer L, Kirschner MW. Control of beta-catenin stability: reconstitution of the cytoplasmic steps of the wnt pathway in Xenopus egg extracts. Mol Cell. 2000 Mar; 5(3):523-32. PMID: 10882137.
    Citations: 145     Fields:    Translation:AnimalsCells
  45. Kroll KL, Salic AN, Evans LM, Kirschner MW. Geminin, a neuralizing molecule that demarcates the future neural plate at the onset of gastrulation. Development. 1998 Aug; 125(16):3247-58. PMID: 9671596.
    Citations: 77     Fields:    Translation:AnimalsCells
  46. Salic AN, Kroll KL, Evans LM, Kirschner MW. Sizzled: a secreted Xwnt8 antagonist expressed in the ventral marginal zone of Xenopus embryos. Development. 1997 Dec; 124(23):4739-48. PMID: 9428410.
    Citations: 37     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.