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Trista Elizabeth North, Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. U01HL134812 (DALEY, GEORGE Q) Sep 23, 2016 - May 31, 2023
    NIH/NHLBI
    Stem cells for therapeutics discovery in genetic blood disorders
    Role: Co-Principal Investigator
  2. R01DK098241 (NORTH, TRISTA E.) Apr 1, 2014 - Mar 31, 2019
    NIH/NIDDK
    Metabolic regulation of hematopoietic stem cell specification and function
    Role: Principal Investigator
  3. R03DK096156 (NORTH, TRISTA E) Aug 7, 2012 - Jul 31, 2014
    NIH/NIDDK
    Integrated signaling of eicosanoids in HSC formation and regeneration
    Role: Principal Investigator
  4. R21OD012227 (NORTH, TRISTA E) Jul 15, 2012 - Jun 30, 2014
    NIH
    Defining Estrogenic Regulation of Hematopoietic Stem Cell Formation and Function
    Role: Principal Investigator
  5. R24DK092760 (DALEY, GEORGE Q) Sep 19, 2011 - Jul 31, 2019
    NIH/NIDDK
    Customized stem cells for clinical application in blood disorders
    Role: Co-Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Rowe RG, Lummertz da Rocha E, Sousa P, Missios P, Morse M, Marion W, Yermalovich A, Barragan J, Mathieu R, Jha DK, Fleming MD, North TE, Daley GQ. The developmental stage of the hematopoietic niche regulates lineage in MLL-rearranged leukemia. J Exp Med. 2019 Mar 04; 216(3):527-538. PMID: 30728174.
    Citations:    
  2. Chaturantabut S, Shwartz A, Evason KJ, Cox AG, Labella K, Schepers AG, Yang S, Acuña M, Houvras Y, Mancio-Silva L, Romano S, Gorelick DA, Cohen DE, Zon LI, Bhatia SN, North TE, Goessling W. Estrogen Activation of G-Protein-Coupled Estrogen Receptor 1 Regulates Phosphoinositide 3-Kinase and mTOR Signaling to Promote Liver Growth in Zebrafish and Proliferation of Human Hepatocytes. Gastroenterology. 2019 05; 156(6):1788-1804.e13. PMID: 30641053.
    Citations:    Fields:    
  3. Lummertz da Rocha E, Rowe RG, Lundin V, Malleshaiah M, Jha DK, Rambo CR, Li H, North TE, Collins JJ, Daley GQ. Reconstruction of complex single-cell trajectories using CellRouter. Nat Commun. 2018 03 01; 9(1):892. PMID: 29497036.
    Citations: 1     Fields:    Translation:HumansCells
  4. Vo LT, Kinney MA, Liu X, Zhang Y, Barragan J, Sousa PM, Jha DK, Han A, Cesana M, Shao Z, North TE, Orkin SH, Doulatov S, Xu J, Daley GQ. Regulation of embryonic haematopoietic multipotency by EZH1. Nature. 2018 01 25; 553(7689):506-510. PMID: 29342143.
    Citations:    Fields:    Translation:HumansAnimalsCells
  5. Oo ZM, Illendula A, Grembecka J, Schmidt C, Zhou Y, Esain V, Kwan W, Frost I, North TE, Rajewski RA, Speck NA, Bushweller JH. A tool compound targeting the core binding factor Runt domain to disrupt binding to CBFß in leukemic cells. Leuk Lymphoma. 2018 09; 59(9):2188-2200. PMID: 29249175.
    Citations:    Fields:    
  6. Theodore LN, Hagedorn EJ, Cortes M, Natsuhara K, Liu SY, Perlin JR, Yang S, Daily ML, Zon LI, North TE. Distinct Roles for Matrix Metalloproteinases 2 and 9 in Embryonic Hematopoietic Stem Cell Emergence, Migration, and Niche Colonization. Stem Cell Reports. 2017 05 09; 8(5):1226-1241. PMID: 28416284.
    Citations: 3     Fields:    Translation:AnimalsCells
  7. Kwan W, North TE. Netting Novel Regulators of Hematopoiesis and Hematologic Malignancies in Zebrafish. Curr Top Dev Biol. 2017; 124:125-160. PMID: 28335858.
    Citations: 3     Fields:    Translation:AnimalsCells
  8. North TE, Goessling W. Haematopoietic stem cells show their true colours. Nat Cell Biol. 2016 Dec 23; 19(1):10-12. PMID: 28008181.
    Citations:    Fields:    Translation:AnimalsCells
  9. Frame JM, Lim SE, North TE. Hematopoietic stem cell development: Using the zebrafish to identify extrinsic and intrinsic mechanisms regulating hematopoiesis. Methods Cell Biol. 2017; 138:165-192. PMID: 28129843.
    Citations: 3     Fields:    Translation:AnimalsCells
  10. Lim SE, Esain V, Kwan W, Theodore LN, Cortes M, Frost IM, Liu SY, North TE. HIF1a-induced PDGFRß signaling promotes developmental HSC production via IL-6 activation. Exp Hematol. 2017 Feb; 46:83-95.e6. PMID: 27751871.
    Citations: 3     Fields:    Translation:AnimalsCells
  11. Cortes M, Chen MJ, Stachura DL, Liu SY, Kwan W, Wright F, Vo LT, Theodore LN, Esain V, Frost IM, Schlaeger TM, Goessling W, Daley GQ, North TE. Developmental Vitamin D Availability Impacts Hematopoietic Stem Cell Production. Cell Rep. 2016 10 04; 17(2):458-468. PMID: 27705794.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  12. Konantz M, Alghisi E, Müller JS, Lenard A, Esain V, Carroll KJ, Kanz L, North TE, Lengerke C. Evi1 regulates Notch activation to induce zebrafish hematopoietic stem cell emergence. EMBO J. 2016 11 02; 35(21):2315-2331. PMID: 27638855.
    Citations: 6     Fields:    Translation:AnimalsCells
  13. Nissim S, Weeks O, Talbot JC, Hedgepeth JW, Wucherpfennig J, Schatzman-Bone S, Swinburne I, Cortes M, Alexa K, Megason S, North TE, Amacher SL, Goessling W. Iterative use of nuclear receptor Nr5a2 regulates multiple stages of liver and pancreas development. Dev Biol. 2016 10 01; 418(1):108-123. PMID: 27474396.
    Citations: 3     Fields:    Translation:AnimalsCells
  14. Luis TC, Tremblay CS, Manz MG, North TE, King KY, Challen GA. Inflammatory signals in HSPC development and homeostasis: Too much of a good thing? Exp Hematol. 2016 10; 44(10):908-12. PMID: 27423816.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  15. Kwan W, Cortes M, Frost I, Esain V, Theodore LN, Liu SY, Budrow N, Goessling W, North TE. The Central Nervous System Regulates Embryonic HSPC Production via Stress-Responsive Glucocorticoid Receptor Signaling. Cell Stem Cell. 2016 09 01; 19(3):370-82. PMID: 27424782.
    Citations: 8     Fields:    Translation:AnimalsCells
  16. Moore FE, Garcia EG, Lobbardi R, Jain E, Tang Q, Moore JC, Cortes M, Molodtsov A, Kasheta M, Luo CC, Garcia AJ, Mylvaganam R, Yoder JA, Blackburn JS, Sadreyev RI, Ceol CJ, North TE, Langenau DM. Single-cell transcriptional analysis of normal, aberrant, and malignant hematopoiesis in zebrafish. J Exp Med. 2016 05 30; 213(6):979-92. PMID: 27139488.
    Citations: 13     Fields:    Translation:AnimalsCells
  17. Goessling W, North TE. EnaBILEing Growth in the Fetal Liver. Cell Stem Cell. 2016 Apr 07; 18(4):427-8. PMID: 27058931.
    Citations:    Fields:    
  18. Kanz D, Konantz M, Alghisi E, North TE, Lengerke C. Endothelial-to-hematopoietic transition: Notch-ing vessels into blood. Ann N Y Acad Sci. 2016 04; 1370(1):97-108. PMID: 27015586.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  19. Liu LY, Alexa K, Cortes M, Schatzman-Bone S, Kim AJ, Mukhopadhyay B, Cinar R, Kunos G, North TE, Goessling W. Cannabinoid receptor signaling regulates liver development and metabolism. Development. 2016 Feb 15; 143(4):609-22. PMID: 26884397.
    Citations: 4     Fields:    Translation:AnimalsCells
  20. Esain V, Cortes M, North TE. Enumerating Hematopoietic Stem and Progenitor Cells in Zebrafish Embryos. Methods Mol Biol. 2016; 1451:191-206. PMID: 27464809.
    Citations: 1     Fields:    Translation:AnimalsCells
  21. Cortes M, Liu SY, Kwan W, Alexa K, Goessling W, North TE. Accumulation of the Vitamin D Precursor Cholecalciferol Antagonizes Hedgehog Signaling to Impair Hemogenic Endothelium Formation. Stem Cell Reports. 2015 Oct 13; 5(4):471-9. PMID: 26365513.
    Citations: 1     Fields:    Translation:AnimalsCells
  22. Esain V, Kwan W, Carroll KJ, Cortes M, Liu SY, Frechette GM, Sheward LM, Nissim S, Goessling W, North TE. Cannabinoid Receptor-2 Regulates Embryonic Hematopoietic Stem Cell Development via Prostaglandin E2 and P-Selectin Activity. Stem Cells. 2015 Aug; 33(8):2596-612. PMID: 25931248.
    Citations: 4     Fields:    Translation:AnimalsCells
  23. Li Y, Esain V, Teng L, Xu J, Kwan W, Frost IM, Yzaguirre AD, Cai X, Cortes M, Maijenburg MW, Tober J, Dzierzak E, Orkin SH, Tan K, North TE, Speck NA. Inflammatory signaling regulates embryonic hematopoietic stem and progenitor cell production. Genes Dev. 2014 Dec 01; 28(23):2597-612. PMID: 25395663.
    Citations: 57     Fields:    Translation:HumansAnimalsCells
  24. Goessling W, North TE. Repairing quite swimmingly: advances in regenerative medicine using zebrafish. Dis Model Mech. 2014 Jul; 7(7):769-76. PMID: 24973747.
    Citations: 11     Fields:    Translation:HumansAnimals
  25. Carroll KJ, Esain V, Garnaas MK, Cortes M, Dovey MC, Nissim S, Frechette GM, Liu SY, Kwan W, Cutting CC, Harris JM, Gorelick DA, Halpern ME, Lawson ND, Goessling W, North TE. Estrogen defines the dorsal-ventral limit of VEGF regulation to specify the location of the hemogenic endothelial niche. Dev Cell. 2014 May 27; 29(4):437-53. PMID: 24871948.
    Citations: 8     Fields:    Translation:AnimalsCells
  26. Carroll KJ, North TE. Oceans of opportunity: exploring vertebrate hematopoiesis in zebrafish. Exp Hematol. 2014 Aug; 42(8):684-96. PMID: 24816275.
    Citations: 12     Fields:    Translation:AnimalsCells
  27. Nissim S, Sherwood RI, Wucherpfennig J, Saunders D, Harris JM, Esain V, Carroll KJ, Frechette GM, Kim AJ, Hwang KL, Cutting CC, Elledge S, North TE, Goessling W. Prostaglandin E2 regulates liver versus pancreas cell-fate decisions and endodermal outgrowth. Dev Cell. 2014 Feb 24; 28(4):423-37. PMID: 24530296.
    Citations: 14     Fields:    Translation:AnimalsCells
  28. Cox AG, Saunders DC, Kelsey PB, Conway AA, Tesmenitsky Y, Marchini JF, Brown KK, Stamler JS, Colagiovanni DB, Rosenthal GJ, Croce KJ, North TE, Goessling W. S-nitrosothiol signaling regulates liver development and improves outcome following toxic liver injury. Cell Rep. 2014 Jan 16; 6(1):56-69. PMID: 24388745.
    Citations: 13     Fields:    Translation:Animals
  29. Cutler C, Multani P, Robbins D, Kim HT, Le T, Hoggatt J, Pelus LM, Desponts C, Chen YB, Rezner B, Armand P, Koreth J, Glotzbecker B, Ho VT, Alyea E, Isom M, Kao G, Armant M, Silberstein L, Hu P, Soiffer RJ, Scadden DT, Ritz J, Goessling W, North TE, Mendlein J, Ballen K, Zon LI, Antin JH, Shoemaker DD. Prostaglandin-modulated umbilical cord blood hematopoietic stem cell transplantation. Blood. 2013 Oct 24; 122(17):3074-81. PMID: 23996087.
    Citations: 92     Fields:    Translation:HumansCellsCTClinical Trials
  30. Liu LY, Fox CS, North TE, Goessling W. Functional validation of GWAS gene candidates for abnormal liver function during zebrafish liver development. Dis Model Mech. 2013 Sep; 6(5):1271-8. PMID: 23813869.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  31. Shan J, Schwartz RE, Ross NT, Logan DJ, Thomas D, Duncan SA, North TE, Goessling W, Carpenter AE, Bhatia SN. Identification of small molecules for human hepatocyte expansion and iPS differentiation. Nat Chem Biol. 2013 Aug; 9(8):514-20. PMID: 23728495.
    Citations: 69     Fields:    Translation:HumansCells
  32. Harris JM, Esain V, Frechette GM, Harris LJ, Cox AG, Cortes M, Garnaas MK, Carroll KJ, Cutting CC, Khan T, Elks PM, Renshaw SA, Dickinson BC, Chang CJ, Murphy MP, Paw BH, Vander Heiden MG, Goessling W, North TE. Glucose metabolism impacts the spatiotemporal onset and magnitude of HSC induction in vivo. Blood. 2013 Mar 28; 121(13):2483-93. PMID: 23341543.
    Citations: 30     Fields:    Translation:AnimalsCells
  33. Garnaas MK, Cutting CC, Meyers A, Kelsey PB, Harris JM, North TE, Goessling W. Rargb regulates organ laterality in a zebrafish model of right atrial isomerism. Dev Biol. 2012 Dec 15; 372(2):178-89. PMID: 22982668.
    Citations: 9     Fields:    Translation:AnimalsCells
  34. Cooney JD, Hildick-Smith GJ, Shafizadeh E, McBride PF, Carroll KJ, Anderson H, Shaw GC, Tamplin OJ, Branco DS, Dalton AJ, Shah DI, Wong C, Gallagher PG, Zon LI, North TE, Paw BH. Teleost growth factor independence (gfi) genes differentially regulate successive waves of hematopoiesis. Dev Biol. 2013 Jan 15; 373(2):431-41. PMID: 22960038.
    Citations: 11     Fields:    Translation:AnimalsCells
  35. Shaik S, Nucera C, Inuzuka H, Gao D, Garnaas M, Frechette G, Harris L, Wan L, Fukushima H, Husain A, Nose V, Fadda G, Sadow PM, Goessling W, North T, Lawler J, Wei W. SCF(ß-TRCP) suppresses angiogenesis and thyroid cancer cell migration by promoting ubiquitination and destruction of VEGF receptor 2. J Exp Med. 2012 Jul 02; 209(7):1289-307. PMID: 22711876.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  36. Leshchiner I, Alexa K, Kelsey P, Adzhubei I, Austin-Tse CA, Cooney JD, Anderson H, King MJ, Stottmann RW, Garnaas MK, Ha S, Drummond IA, Paw BH, North TE, Beier DR, Goessling W, Sunyaev SR. Mutation mapping and identification by whole-genome sequencing. Genome Res. 2012 Aug; 22(8):1541-8. PMID: 22555591.
    Citations: 53     Fields:    Translation:AnimalsCells
  37. Colanesi S, Taylor KL, Temperley ND, Lundegaard PR, Liu D, North TE, Ishizaki H, Kelsh RN, Patton EE. Small molecule screening identifies targetable zebrafish pigmentation pathways. Pigment Cell Melanoma Res. 2012 Mar; 25(2):131-43. PMID: 22252091.
    Citations: 14     Fields:    Translation:AnimalsCells
  38. Goessling W, Allen RS, Guan X, Jin P, Uchida N, Dovey M, Harris JM, Metzger ME, Bonifacino AC, Stroncek D, Stegner J, Armant M, Schlaeger T, Tisdale JF, Zon LI, Donahue RE, North TE. Prostaglandin E2 enhances human cord blood stem cell xenotransplants and shows long-term safety in preclinical nonhuman primate transplant models. Cell Stem Cell. 2011 Apr 08; 8(4):445-58. PMID: 21474107.
    Citations: 97     Fields:    Translation:HumansAnimals
  39. North TE, Goessling W. Endoderm specification, liver development, and regeneration. Methods Cell Biol. 2011; 101:205-23. PMID: 21550446.
    Citations: 5     Fields:    Translation:Animals
  40. Goessling W, North TE. Hematopoietic stem cell development: using the zebrafish to identify the signaling networks and physical forces regulating hematopoiesis. Methods Cell Biol. 2011; 105:117-36. PMID: 21951528.
    Citations: 4     Fields:    Translation:AnimalsCells
  41. North TE, Babu IR, Vedder LM, Lord AM, Wishnok JS, Tannenbaum SR, Zon LI, Goessling W. PGE2-regulated wnt signaling and N-acetylcysteine are synergistically hepatoprotective in zebrafish acetaminophen injury. Proc Natl Acad Sci U S A. 2010 Oct 05; 107(40):17315-20. PMID: 20855591.
    Citations: 41     Fields:    Translation:AnimalsCells
  42. Wang Y, Krivtsov AV, Sinha AU, North TE, Goessling W, Feng Z, Zon LI, Armstrong SA. The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML. Science. 2010 Mar 26; 327(5973):1650-3. PMID: 20339075.
    Citations: 244     Fields:    Translation:AnimalsCells
  43. North TE, Goessling W. Previews. NOTCHing an arrow at cord blood: translating stem cell knowledge into clinical practice. Cell Stem Cell. 2010 Mar 05; 6(3):186-7. PMID: 20207217.
    Citations: 2     Fields:    
  44. North TE, Goessling W, Peeters M, Li P, Ceol C, Lord AM, Weber GJ, Harris J, Cutting CC, Huang P, Dzierzak E, Zon LI. Hematopoietic stem cell development is dependent on blood flow. Cell. 2009 May 15; 137(4):736-48. PMID: 19450519.
    Citations: 144     Fields:    Translation:AnimalsCells
  45. Dovey M, Patton EE, Bowman T, North T, Goessling W, Zhou Y, Zon LI. Topoisomerase II alpha is required for embryonic development and liver regeneration in zebrafish. Mol Cell Biol. 2009 Jul; 29(13):3746-53. PMID: 19380487.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  46. Goessling W, North TE, Loewer S, Lord AM, Lee S, Stoick-Cooper CL, Weidinger G, Puder M, Daley GQ, Moon RT, Zon LI. Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration. Cell. 2009 Mar 20; 136(6):1136-47. PMID: 19303855.
    Citations: 238     Fields:    Translation:AnimalsCells
  47. Upadhyay G, Goessling W, North TE, Xavier R, Zon LI, Yajnik V. Molecular association between beta-catenin degradation complex and Rac guanine exchange factor DOCK4 is essential for Wnt/beta-catenin signaling. Oncogene. 2008 Oct 02; 27(44):5845-55. PMID: 18641688.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  48. Goessling W, North TE, Lord AM, Ceol C, Lee S, Weidinger G, Bourque C, Strijbosch R, Haramis AP, Puder M, Clevers H, Moon RT, Zon LI. APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development. Dev Biol. 2008 Aug 01; 320(1):161-74. PMID: 18585699.
    Citations: 80     Fields:    Translation:AnimalsCells
  49. Lord AM, North TE, Zon LI. Prostaglandin E2: making more of your marrow. Cell Cycle. 2007 Dec 15; 6(24):3054-7. PMID: 18075310.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  50. North TE, Goessling W, Walkley CR, Lengerke C, Kopani KR, Lord AM, Weber GJ, Bowman TV, Jang IH, Grosser T, Fitzgerald GA, Daley GQ, Orkin SH, Zon LI. Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis. Nature. 2007 Jun 21; 447(7147):1007-11. PMID: 17581586.
    Citations: 381     Fields:    Translation:AnimalsCells
  51. Goessling W, North TE, Zon LI. Ultrasound biomicroscopy permits in vivo characterization of zebrafish liver tumors. Nat Methods. 2007 Jul; 4(7):551-3. PMID: 17572681.
    Citations: 22     Fields:    Translation:Animals
  52. Goessling W, North TE, Zon LI. New waves of discovery: modeling cancer in zebrafish. J Clin Oncol. 2007 Jun 10; 25(17):2473-9. PMID: 17557959.
    Citations: 31     Fields:    Translation:HumansAnimals
  53. North TE, Stacy T, Matheny CJ, Speck NA, de Bruijn MF. Runx1 is expressed in adult mouse hematopoietic stem cells and differentiating myeloid and lymphoid cells, but not in maturing erythroid cells. Stem Cells. 2004; 22(2):158-68. PMID: 14990855.
    Citations: 33     Fields:    Translation:AnimalsCells
  54. North TE, Zon LI. Modeling human hematopoietic and cardiovascular diseases in zebrafish. Dev Dyn. 2003 Nov; 228(3):568-83. PMID: 14579393.
    Citations: 12     Fields:    Translation:HumansAnimals
  55. North TE, de Bruijn MF, Stacy T, Talebian L, Lind E, Robin C, Binder M, Dzierzak E, Speck NA. Runx1 expression marks long-term repopulating hematopoietic stem cells in the midgestation mouse embryo. Immunity. 2002 May; 16(5):661-72. PMID: 12049718.
    Citations: 180     Fields:    Translation:AnimalsCells
  56. North T, Gu TL, Stacy T, Wang Q, Howard L, Binder M, Marín-Padilla M, Speck NA. Cbfa2 is required for the formation of intra-aortic hematopoietic clusters. Development. 1999 Jun; 126(11):2563-75. PMID: 10226014.
    Citations: 191     Fields:    Translation:AnimalsCells
  57. Speck NA, Stacy T, Wang Q, North T, Gu TL, Miller J, Binder M, Marín-Padilla M. Core-binding factor: a central player in hematopoiesis and leukemia. Cancer Res. 1999 Apr 01; 59(7 Suppl):1789s-1793s. PMID: 10197598.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.