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Dana H. Boyd, Ph.D.

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  1. R01GM041883 (BOYD, DANA) Jun 1, 1989 - Feb 28, 2017
    NIH
    Microbial Diversity in Mechanisms of Disulfide Bond Formation and Reduction
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Landeta C, McPartland L, Tran NQ, Meehan BM, Zhang Y, Tanweer Z, Wakabayashi S, Rock J, Kim T, Balasubramanian D, Audette R, Toosky M, Pinkham J, Rubin EJ, Lory S, Pier G, Boyd D, Beckwith J. Inhibition of Pseudomonas aeruginosa and Mycobacterium tuberculosis disulfide bond forming enzymes. Mol Microbiol. 2019 04; 111(4):918-937. PMID: 30556355; PMCID: PMC6458069.
    Citations: 10     Fields:    Translation:AnimalsCells
  2. Ke N, Landeta C, Wang X, Boyd D, Eser M, Beckwith J. Identification of the Thioredoxin Partner of Vitamin K Epoxide Reductase in Mycobacterial Disulfide Bond Formation. J Bacteriol. 2018 08 15; 200(16). PMID: 29784887; PMCID: PMC6060362.
    Citations: 2     Fields:    Translation:Cells
  3. Landeta C, Boyd D, Beckwith J. Disulfide bond formation in prokaryotes. Nat Microbiol. 2018 03; 3(3):270-280. PMID: 29463925.
    Citations: 53     Fields:    Translation:HumansCells
  4. Meehan BM, Landeta C, Boyd D, Beckwith J. The Disulfide Bond Formation Pathway Is Essential for Anaerobic Growth of Escherichia coli. J Bacteriol. 2017 08 15; 199(16). PMID: 28559299; PMCID: PMC5527382.
    Citations: 12     Fields:    Translation:Cells
  5. Landeta C, Meehan BM, McPartland L, Ingendahl L, Hatahet F, Tran NQ, Boyd D, Beckwith J. Inhibition of virulence-promoting disulfide bond formation enzyme DsbB is blocked by mutating residues in two distinct regions. J Biol Chem. 2017 04 21; 292(16):6529-6541. PMID: 28232484.
    Citations: 7     Fields:    Translation:Cells
  6. Meehan BM, Landeta C, Boyd D, Beckwith J. The essential cell division protein FtsN contains a critical disulfide bond in a non-essential domain. Mol Microbiol. 2017 02; 103(3):413-422. PMID: 27785850; PMCID: PMC5262531.
    Citations: 9     Fields:    Translation:Cells
  7. Hatahet F, Blazyk JL, Martineau E, Mandela E, Zhao Y, Campbell RE, Beckwith J, Boyd D. Altered Escherichia coli membrane protein assembly machinery allows proper membrane assembly of eukaryotic protein vitamin K epoxide reductase. Proc Natl Acad Sci U S A. 2015 Dec 08; 112(49):15184-9. PMID: 26598701; PMCID: PMC4679017.
    Citations: 5     Fields:    Translation:AnimalsCells
  8. Landeta C, Blazyk JL, Hatahet F, Meehan BM, Eser M, Myrick A, Bronstain L, Minami S, Arnold H, Ke N, Rubin EJ, Furie BC, Furie B, Beckwith J, Dutton R, Boyd D. Compounds targeting disulfide bond forming enzyme DsbB of Gram-negative bacteria. Nat Chem Biol. 2015 Apr; 11(4):292-8. PMID: 25686372; PMCID: PMC4366281.
    Citations: 20     Fields:    Translation:Cells
  9. Dwyer RS, Malinverni JC, Boyd D, Beckwith J, Silhavy TJ. Folding LacZ in the periplasm of Escherichia coli. J Bacteriol. 2014 Sep; 196(18):3343-50. PMID: 25002543.
    Citations: 7     Fields:    Translation:Cells
  10. Hatahet F, Boyd D, Beckwith J. Disulfide bond formation in prokaryotes: history, diversity and design. Biochim Biophys Acta. 2014 Aug; 1844(8):1402-14. PMID: 24576574.
    Citations: 57     Fields:    Translation:HumansAnimalsCells
  11. Li Z, Boyd D, Reindl M, Goldberg MB. Identification of YidC residues that define interactions with the Sec Apparatus. J Bacteriol. 2014 Jan; 196(2):367-77. PMID: 24187090.
    Citations: 8     Fields:    Translation:Cells
  12. O'Connor TJ, Boyd D, Dorer MS, Isberg RR. Aggravating genetic interactions allow a solution to redundancy in a bacterial pathogen. Science. 2012 Dec 14; 338(6113):1440-4. PMID: 23239729; PMCID: PMC3780440.
    Citations: 63     Fields:    Translation:HumansAnimalsCells
  13. Gray AN, Henderson-Frost JM, Boyd D, Sharafi S, Niki H, Goldberg MB. Unbalanced Charge Distribution as a Determinant for Dependence of a Subset of Escherichia coli Membrane Proteins on the Membrane Insertase YidC. MBio. 2012; 3(6). PMID: 23188509.
    Citations:    
  14. Chng SS, Xue M, Garner RA, Kadokura H, Boyd D, Beckwith J, Kahne D. Disulfide rearrangement triggered by translocon assembly controls lipopolysaccharide export. Science. 2012 Sep 28; 337(6102):1665-8. PMID: 22936569.
    Citations: 51     Fields:    Translation:Cells
  15. Gray AN, Henderson-Frost JM, Boyd D, Sharafi S, Shirafi S, Niki H, Goldberg MB. Unbalanced charge distribution as a determinant for dependence of a subset of Escherichia coli membrane proteins on the membrane insertase YidC. mBio. 2011; 2(6). PMID: 22108384.
    Citations: 11     Fields:    Translation:Cells
  16. O'Connor TJ, Adepoju Y, Boyd D, Isberg RR. Minimization of the Legionella pneumophila genome reveals chromosomal regions involved in host range expansion. Proc Natl Acad Sci U S A. 2011 Sep 06; 108(36):14733-40. PMID: 21873199.
    Citations: 92     Fields:    Translation:AnimalsCells
  17. Feeney MA, Veeravalli K, Boyd D, Gon S, Faulkner MJ, Georgiou G, Beckwith J. Repurposing lipoic acid changes electron flow in two important metabolic pathways of Escherichia coli. Proc Natl Acad Sci U S A. 2011 May 10; 108(19):7991-6. PMID: 21521794.
    Citations: 9     Fields:    Translation:Cells
  18. Wang X, Dutton RJ, Beckwith J, Boyd D. Membrane topology and mutational analysis of Mycobacterium tuberculosis VKOR, a protein involved in disulfide bond formation and a homologue of human vitamin K epoxide reductase. Antioxid Redox Signal. 2011 Apr 15; 14(8):1413-20. PMID: 20969481.
    Citations: 31     Fields:    Translation:HumansCells
  19. Veeravalli K, Boyd D, Iverson BL, Beckwith J, Georgiou G. Laboratory evolution of glutathione biosynthesis reveals natural compensatory pathways. Nat Chem Biol. 2011 Feb; 7(2):101-5. PMID: 21186348.
    Citations: 21     Fields:    
  20. Huang L, Boyd D, Amyot WM, Hempstead AD, Luo ZQ, O'Connor TJ, Chen C, Machner M, Montminy T, Isberg RR. The E Block motif is associated with Legionella pneumophila translocated substrates. Cell Microbiol. 2011 Feb; 13(2):227-45. PMID: 20880356; PMCID: PMC3096851.
    Citations: 93     Fields:    Translation:Cells
  21. Gonzalez MD, Akbay EA, Boyd D, Beckwith J. Multiple interaction domains in FtsL, a protein component of the widely conserved bacterial FtsLBQ cell division complex. J Bacteriol. 2010 Jun; 192(11):2757-68. PMID: 20363951.
    Citations: 30     Fields:    Translation:Cells
  22. Li W, Schulman S, Dutton RJ, Boyd D, Beckwith J, Rapoport TA. Structure of a bacterial homologue of vitamin K epoxide reductase. Nature. 2010 Jan 28; 463(7280):507-12. PMID: 20110994.
    Citations: 81     Fields:    Translation:HumansAnimalsCells
  23. Dutton RJ, Wayman A, Wei JR, Rubin EJ, Beckwith J, Boyd D. Inhibition of bacterial disulfide bond formation by the anticoagulant warfarin. Proc Natl Acad Sci U S A. 2010 Jan 05; 107(1):297-301. PMID: 20018758.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  24. Shouldice SR, Cho SH, Boyd D, Heras B, Eser M, Beckwith J, Riggs P, Martin JL, Berkmen M. In vivo oxidative protein folding can be facilitated by oxidation-reduction cycling. Mol Microbiol. 2010 Jan; 75(1):13-28. PMID: 19968787.
    Citations: 19     Fields:    Translation:Cells
  25. Dutton RJ, Boyd D, Berkmen M, Beckwith J. Bacterial species exhibit diversity in their mechanisms and capacity for protein disulfide bond formation. Proc Natl Acad Sci U S A. 2008 Aug 19; 105(33):11933-8. PMID: 18695247.
    Citations: 124     Fields:    Translation:Cells
  26. Yamamoto Y, Ritz D, Planson AG, Jönsson TJ, Faulkner MJ, Boyd D, Beckwith J, Poole LB. Mutant AhpC peroxiredoxins suppress thiol-disulfide redox deficiencies and acquire deglutathionylating activity. Mol Cell. 2008 Jan 18; 29(1):36-45. PMID: 18206967.
    Citations: 24     Fields:    Translation:Cells
  27. Mac TT, von Hacht A, Hung KC, Dutton RJ, Boyd D, Bardwell JC, Ulmer TS. Insight into disulfide bond catalysis in Chlamydia from the structure and function of DsbH, a novel oxidoreductase. J Biol Chem. 2008 Jan 11; 283(2):824-32. PMID: 18003611.
    Citations: 9     Fields:    Translation:HumansCells
  28. Charity JC, Costante-Hamm MM, Balon EL, Boyd DH, Rubin EJ, Dove SL. Twin RNA polymerase-associated proteins control virulence gene expression in Francisella tularensis. PLoS Pathog. 2007 Jun; 3(6):e84. PMID: 17571921; PMCID: PMC1891329.
    Citations: 87     Fields:    Translation:Cells
  29. Li W, Schulman S, Boyd D, Erlandson K, Beckwith J, Rapoport TA. The plug domain of the SecY protein stabilizes the closed state of the translocation channel and maintains a membrane seal. Mol Cell. 2007 May 25; 26(4):511-21. PMID: 17531810.
    Citations: 56     Fields:    Translation:Cells
  30. Eser M, Henrichs T, Boyd D, Ehrmann M. Target-directed proteolysis in vivo. Methods Enzymol. 2007; 421:68-83. PMID: 17352916.
    Citations: 1     Fields:    Translation:Cells
  31. Goehring NW, Petrovska I, Boyd D, Beckwith J. Mutants, suppressors, and wrinkled colonies: mutant alleles of the cell division gene ftsQ point to functional domains in FtsQ and a role for domain 1C of FtsA in divisome assembly. J Bacteriol. 2007 Jan; 189(2):633-45. PMID: 16980443; PMCID: PMC1797389.
    Citations: 32     Fields:    Translation:Cells
  32. Huber D, Boyd D, Xia Y, Olma MH, Gerstein M, Beckwith J. Use of thioredoxin as a reporter to identify a subset of Escherichia coli signal sequences that promote signal recognition particle-dependent translocation. J Bacteriol. 2005 May; 187(9):2983-91. PMID: 15838024; PMCID: PMC1082830.
    Citations: 58     Fields:    Translation:Cells
  33. Henrichs T, Mikhaleva N, Conz C, Deuerling E, Boyd D, Zelazny A, Bibi E, Ban N, Ehrmann M. Target-directed proteolysis at the ribosome. Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12):4246-51. PMID: 15784745; PMCID: PMC555484.
    Citations: 6     Fields:    Translation:Cells
  34. Berkmen M, Boyd D, Beckwith J. The nonconsecutive disulfide bond of Escherichia coli phytase (AppA) renders it dependent on the protein-disulfide isomerase, DsbC. J Biol Chem. 2005 Mar 25; 280(12):11387-94. PMID: 15642731.
    Citations: 53     Fields:    Translation:Cells
  35. Or E, Boyd D, Gon S, Beckwith J, Rapoport T. The bacterial ATPase SecA functions as a monomer in protein translocation. J Biol Chem. 2005 Mar 11; 280(10):9097-105. PMID: 15618215.
    Citations: 48     Fields:    Translation:Cells
  36. Goodman AL, Kulasekara B, Rietsch A, Boyd D, Smith RS, Lory S. A signaling network reciprocally regulates genes associated with acute infection and chronic persistence in Pseudomonas aeruginosa. Dev Cell. 2004 Nov; 7(5):745-54. PMID: 15525535.
    Citations: 289     Fields:    Translation:AnimalsCells
  37. Ehrle R, Mikhaleva N, Boyd D, Davidson AL, Ehrmann M. Context-dependent effects of charged residues in transmembrane segments of MalF-PhoA fusions. Res Microbiol. 2003 Nov; 154(9):654-7. PMID: 14596903.
    Citations:    Fields:    Translation:Cells
  38. Schierle CF, Berkmen M, Huber D, Kumamoto C, Boyd D, Beckwith J. The DsbA signal sequence directs efficient, cotranslational export of passenger proteins to the Escherichia coli periplasm via the signal recognition particle pathway. J Bacteriol. 2003 Oct; 185(19):5706-13. PMID: 13129941.
    Citations: 93     Fields:    Translation:Cells
  39. Wolfgang MC, Kulasekara BR, Liang X, Boyd D, Wu K, Yang Q, Miyada CG, Lory S. Conservation of genome content and virulence determinants among clinical and environmental isolates of Pseudomonas aeruginosa. Proc Natl Acad Sci U S A. 2003 Jul 08; 100(14):8484-9. PMID: 12815109; PMCID: PMC166255.
    Citations: 175     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  40. Sassetti CM, Boyd DH, Rubin EJ. Genes required for mycobacterial growth defined by high density mutagenesis. Mol Microbiol. 2003 Apr; 48(1):77-84. PMID: 12657046.
    Citations: 1106     Fields:    Translation:Cells
  41. Buddelmeijer N, Judson N, Boyd D, Mekalanos JJ, Beckwith J. YgbQ, a cell division protein in Escherichia coli and Vibrio cholerae, localizes in codependent fashion with FtsL to the division site. Proc Natl Acad Sci U S A. 2002 Apr 30; 99(9):6316-21. PMID: 11972052; PMCID: PMC122946.
    Citations: 46     Fields:    Translation:Cells
  42. Dziejman M, Balon E, Boyd D, Fraser CM, Heidelberg JF, Mekalanos JJ. Comparative genomic analysis of Vibrio cholerae: genes that correlate with cholera endemic and pandemic disease. Proc Natl Acad Sci U S A. 2002 Feb 05; 99(3):1556-61. PMID: 11818571; PMCID: PMC122229.
    Citations: 203     Fields:    Translation:HumansCells
  43. Sassetti CM, Boyd DH, Rubin EJ. Comprehensive identification of conditionally essential genes in mycobacteria. Proc Natl Acad Sci U S A. 2001 Oct 23; 98(22):12712-7. PMID: 11606763; PMCID: PMC60119.
    Citations: 270     Fields:    Translation:Cells
  44. Leeds JA, Boyd D, Huber DR, Sonoda GK, Luu HT, Engelman DM, Beckwith J. Genetic selection for and molecular dynamic modeling of a protein transmembrane domain multimerization motif from a random Escherichia coli genomic library. J Mol Biol. 2001 Oct 12; 313(1):181-95. PMID: 11601855.
    Citations: 9     Fields:    Translation:Cells
  45. Kwon O, Georgellis D, Lynch AS, Boyd D, Lin EC. The ArcB sensor kinase of Escherichia coli: genetic exploration of the transmembrane region. J Bacteriol. 2000 May; 182(10):2960-6. PMID: 10781568.
    Citations: 25     Fields:    Translation:Cells
  46. Tian H, Boyd D, Beckwith J. A mutant hunt for defects in membrane protein assembly yields mutations affecting the bacterial signal recognition particle and Sec machinery. Proc Natl Acad Sci U S A. 2000 Apr 25; 97(9):4730-5. PMID: 10781078; PMCID: PMC18301.
    Citations: 37     Fields:    Translation:Cells
  47. Boyd D, Weiss DS, Chen JC, Beckwith J. Towards single-copy gene expression systems making gene cloning physiologically relevant: lambda InCh, a simple Escherichia coli plasmid-chromosome shuttle system. J Bacteriol. 2000 Feb; 182(3):842-7. PMID: 10633125.
    Citations: 98     Fields:    Translation:Cells
  48. Pellicer MT, Lynch AS, De Wulf P, Boyd D, Aguilar J, Lin EC. A mutational study of the ArcA-P binding sequences in the aldA promoter of Escherichia coli. Mol Gen Genet. 1999 Feb; 261(1):170-6. PMID: 10071223.
    Citations: 9     Fields:    Translation:Cells
  49. Weiss DS, Chen JC, Ghigo JM, Boyd D, Beckwith J. Localization of FtsI (PBP3) to the septal ring requires its membrane anchor, the Z ring, FtsA, FtsQ, and FtsL. J Bacteriol. 1999 Jan; 181(2):508-20. PMID: 9882665; PMCID: PMC93405.
    Citations: 220     Fields:    Translation:Cells
  50. Pogliano J, Dong JM, De Wulf P, Furlong D, Boyd D, Losick R, Pogliano K, Lin EC. Aberrant cell division and random FtsZ ring positioning in Escherichia coli cpxA* mutants. J Bacteriol. 1998 Jul; 180(13):3486-90. PMID: 9642209; PMCID: PMC107311.
    Citations: 13     Fields:    Translation:Cells
  51. Prinz WA, Boyd DH, Ehrmann M, Beckwith J. The protein translocation apparatus contributes to determining the topology of an integral membrane protein in Escherichia coli. J Biol Chem. 1998 Apr 03; 273(14):8419-24. PMID: 9525953.
    Citations: 8     Fields:    Translation:Cells
  52. Boyd D, Schierle C, Beckwith J. How many membrane proteins are there? Protein Sci. 1998 Jan; 7(1):201-5. PMID: 9514275; PMCID: PMC2143806.
    Citations: 38     Fields:    Translation:Cells
  53. Traxler B, Boyd D, Beckwith J. The topological analysis of integral cytoplasmic membrane proteins. J Membr Biol. 1993 Feb; 132(1):1-11. PMID: 8459445.
    Citations: 38     Fields:    Translation:Cells
  54. Boyd D, Traxler B, Beckwith J. Analysis of the topology of a membrane protein by using a minimum number of alkaline phosphatase fusions. J Bacteriol. 1993 Jan; 175(2):553-6. PMID: 8419303; PMCID: PMC196172.
    Citations: 28     Fields:    Translation:Cells
  55. Boyd D, Traxler B, Jander G, Prinz W, Beckwith J. Gene fusion approaches to membrane protein topology. Soc Gen Physiol Ser. 1993; 48:23-37. PMID: 8503047.
    Citations:    Fields:    Translation:Cells
  56. Traxler B, Lee C, Boyd D, Beckwith J. The dynamics of assembly of a cytoplasmic membrane protein in Escherichia coli. J Biol Chem. 1992 Mar 15; 267(8):5339-45. PMID: 1544915.
    Citations: 16     Fields:    Translation:Cells
  57. Ehrmann M, Boyd D, Beckwith J. Genetic analysis of membrane protein topology by a sandwich gene fusion approach. Proc Natl Acad Sci U S A. 1990 Oct; 87(19):7574-8. PMID: 2170984; PMCID: PMC54790.
    Citations: 52     Fields:    Translation:Cells
  58. Boyd D, Beckwith J. The role of charged amino acids in the localization of secreted and membrane proteins. Cell. 1990 Sep 21; 62(6):1031-3. PMID: 2205394.
    Citations: 64     Fields:    Translation:Cells
  59. Boyd D, Beckwith J. Positively charged amino acid residues can act as topogenic determinants in membrane proteins. Proc Natl Acad Sci U S A. 1989 Dec; 86(23):9446-50. PMID: 2594779; PMCID: PMC298513.
    Citations: 45     Fields:    Translation:Cells
  60. San Millan JL, Boyd D, Dalbey R, Wickner W, Beckwith J. Use of phoA fusions to study the topology of the Escherichia coli inner membrane protein leader peptidase. J Bacteriol. 1989 Oct; 171(10):5536-41. PMID: 2551889; PMCID: PMC210394.
    Citations: 39     Fields:    Translation:Cells
  61. Manoil C, Boyd D, Beckwith J. Molecular genetic analysis of membrane protein topology. Trends Genet. 1988 Aug; 4(8):223-6. PMID: 3072723.
    Citations: 19     Fields:    Translation:Cells
  62. Froshauer S, Green GN, Boyd D, McGovern K, Beckwith J. Genetic analysis of the membrane insertion and topology of MalF, a cytoplasmic membrane protein of Escherichia coli. J Mol Biol. 1988 Apr 05; 200(3):501-11. PMID: 3294421.
    Citations: 65     Fields:    Translation:Cells
  63. Boyd D, Manoil C, Beckwith J. Determinants of membrane protein topology. Proc Natl Acad Sci U S A. 1987 Dec; 84(23):8525-9. PMID: 3317413; PMCID: PMC299577.
    Citations: 130     Fields:    Translation:Cells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.