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Gokhan S. Hotamisligil, Ph.D., M.D.

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Overview
The major interest of my laboratory is to study the regulatory pathways, which control glucose and lipid metabolism. Our biochemical and genetic studies focus on signal transduction using cultured mammalian cells as well as transgenic animals to identify specific abnormalities in these pathways, which are involved in human metabolic and inflammatory diseases including obesity, diabetes, fatty liver disease, atherosclerosis, and asthma.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01DK123458 (HOTAMISLIGIL, GOKHAN S) Dec 15, 2019 - Nov 30, 2023
    NIH/NIDDK
    Role of Adipokine FABP4 in Glucoregulation and Counter Regulatory Responses
    Role: Principal Investigator
  2. R01HL148137 (HOTAMISLIGIL, GOKHAN S) Aug 1, 2019 - Jul 31, 2023
    NIH/NHLBI
    Novel pathways controlling macrophage inflammation and resolution in atherosclerosis
    Role: Principal Investigator
  3. R01AI116901 (HOTAMISLIGIL, GOKHAN S) Mar 15, 2015 - Feb 28, 2019
    NIH/NIAID
    The role of fatty acid binding protein aP2 in the pathogenesis and treatment of asthma
    Role: Principal Investigator
  4. R01HL125753 (HOTAMISLIGIL, GOKHAN S) Nov 15, 2014 - Oct 31, 2018
    NIH/NHLBI
    The role of immunometabolic pathways in atherosclerosis
    Role: Principal Investigator
  5. RC4DK090942 (HOTAMISLIGIL, GOKHAN S) Sep 30, 2010 - Sep 29, 2013
    NIH/NIDDK
    Deconvolution of adaptive metabolic responses of the endoplasmic reticulum
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Tirosh A, Calay ES, Tuncman G, Claiborn KC, Inouye KE, Eguchi K, Alcala M, Rathaus M, Hollander KS, Ron I, Livne R, Heianza Y, Qi L, Shai I, Garg R, Hotamisligil GS. The short-chain fatty acid propionate increases glucagon and FABP4 production, impairing insulin action in mice and humans. Sci Transl Med. 2019 04 24; 11(489). PMID: 31019023.
    Citations:    
  2. Prentice KJ, Saksi J, Hotamisligil GS. Adipokine FABP4 integrates energy stores and counterregulatory metabolic responses. J Lipid Res. 2019 04; 60(4):734-740. PMID: 30705117.
    Citations:    Fields:    
  3. Hotamisligil GS. Foundations of Immunometabolism and Implications for Metabolic Health and Disease. Immunity. 2017 09 19; 47(3):406-420. PMID: 28930657.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  4. Yu CW, Liang X, Lipsky S, Karaaslan C, Kozakewich H, Hotamisligil GS, Bischoff J, Cataltepe S. Dual role of fatty acid-binding protein 5 on endothelial cell fate: a potential link between lipid metabolism and angiogenic responses. Angiogenesis. 2016 Jan; 19(1):95-106. PMID: 26625874.
    Citations: 5     Fields:    Translation:AnimalsCells
  5. Zhou Y, Yu X, Chen H, Sjöberg S, Roux J, Zhang L, Ivoulsou AH, Bensaid F, Liu CL, Liu J, Tordjman J, Clement K, Lee CH, Hotamisligil GS, Libby P, Shi GP. Leptin Deficiency Shifts Mast Cells toward Anti-Inflammatory Actions and Protects Mice from Obesity and Diabetes by Polarizing M2 Macrophages. Cell Metab. 2015 Dec 01; 22(6):1045-58. PMID: 26481668.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  6. Saint-Geniez M, Ghelfi E, Liang X, Yu C, Spencer C, Abend S, Hotamisligil G, Cataltepe S. Fatty acid binding protein 4 deficiency protects against oxygen-induced retinopathy in mice. PLoS One. 2014; 9(5):e96253. PMID: 24802082.
    Citations: 5     Fields:    Translation:Animals
  7. Yalcin A, Hotamisligil GS. Impact of ER protein homeostasis on metabolism. Diabetes. 2013 Mar; 62(3):691-3. PMID: 23431011.
    Citations: 8     Fields:    Translation:HumansAnimals
  8. Mozaffarian D, de Oliveira Otto MC, Lemaitre RN, Fretts AM, Hotamisligil G, Tsai MY, Siscovick DS, Nettleton JA. trans-Palmitoleic acid, other dairy fat biomarkers, and incident diabetes: the Multi-Ethnic Study of Atherosclerosis (MESA). Am J Clin Nutr. 2013 Apr; 97(4):854-61. PMID: 23407305.
    Citations: 42     Fields:    Translation:HumansCellsCTClinical Trials
  9. Elmasri H, Ghelfi E, Yu CW, Traphagen S, Cernadas M, Cao H, Shi GP, Plutzky J, Sahin M, Hotamisligil G, Cataltepe S. Endothelial cell-fatty acid binding protein 4 promotes angiogenesis: role of stem cell factor/c-kit pathway. Angiogenesis. 2012 Sep; 15(3):457-68. PMID: 22562362.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  10. Hotamisligil GS. Endoplasmic reticulum stress and atherosclerosis. Nat Med. 2010 Apr; 16(4):396-9. PMID: 20376052.
    Citations: 83     Fields:    Translation:HumansAnimalsCells
  11. Hotamisligil GS. Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell. 2010 Mar 19; 140(6):900-17. PMID: 20303879.
    Citations: 717     Fields:    Translation:HumansAnimalsCells
  12. Liu J, Divoux A, Sun J, Zhang J, Clément K, Glickman JN, Sukhova GK, Wolters PJ, Du J, Gorgun CZ, Doria A, Libby P, Blumberg RS, Kahn BB, Hotamisligil GS, Shi GP. Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice. Nat Med. 2009 Aug; 15(8):940-5. PMID: 19633655.
    Citations: 220     Fields:    Translation:HumansAnimalsCells
  13. Chavey C, Lazennec G, Lagarrigue S, Clapé C, Iankova I, Teyssier J, Annicotte JS, Schmidt J, Mataki C, Yamamoto H, Sanches R, Guma A, Stich V, Vitkova M, Jardin-Watelet B, Renard E, Strieter R, Tuthill A, Hotamisligil GS, Vidal-Puig A, Zorzano A, Langin D, Fajas L. CXC ligand 5 is an adipose-tissue derived factor that links obesity to insulin resistance. Cell Metab. 2009 Apr; 9(4):339-49. PMID: 19356715.
    Citations: 60     Fields:    Translation:HumansAnimalsCells
  14. Gregor MF, Yang L, Fabbrini E, Mohammed BS, Eagon JC, Hotamisligil GS, Klein S. Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight loss. Diabetes. 2009 Mar; 58(3):693-700. PMID: 19066313.
    Citations: 150     Fields:    Translation:HumansCells
  15. Hotamisligil GS. Inflammation and endoplasmic reticulum stress in obesity and diabetes. Int J Obes (Lond). 2008 Dec; 32 Suppl 7:S52-4. PMID: 19136991.
    Citations: 85     Fields:    Translation:HumansAnimalsCells
  16. Hotamisligil GS, Erbay E. Nutrient sensing and inflammation in metabolic diseases. Nat Rev Immunol. 2008 Dec; 8(12):923-34. PMID: 19029988.
    Citations: 258     Fields:    Translation:HumansAnimalsCells
  17. Yang L, Hotamisligil GS. Stressing the brain, fattening the body. Cell. 2008 Oct 03; 135(1):20-2. PMID: 18854151.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  18. Cao H, Gerhold K, Mayers JR, Wiest MM, Watkins SM, Hotamisligil GS. Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism. Cell. 2008 Sep 19; 134(6):933-44. PMID: 18805087.
    Citations: 305     Fields:    Translation:AnimalsCells
  19. Vallerie SN, Furuhashi M, Fucho R, Hotamisligil GS. A predominant role for parenchymal c-Jun amino terminal kinase (JNK) in the regulation of systemic insulin sensitivity. PLoS One. 2008 Sep 05; 3(9):e3151. PMID: 18773087.
    Citations: 49     Fields:    Translation:AnimalsCells
  20. Furuhashi M, Fucho R, Görgün CZ, Tuncman G, Cao H, Hotamisligil GS. Adipocyte/macrophage fatty acid-binding proteins contribute to metabolic deterioration through actions in both macrophages and adipocytes in mice. J Clin Invest. 2008 Jul; 118(7):2640-50. PMID: 18551191.
    Citations: 101     Fields:    Translation:AnimalsCells
  21. Furuhashi M, Hotamisligil GS. Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets. Nat Rev Drug Discov. 2008 Jun; 7(6):489-503. PMID: 18511927.
    Citations: 301     Fields:    Translation:HumansAnimalsCells
  22. Ozcan U, Ozcan L, Yilmaz E, Düvel K, Sahin M, Manning BD, Hotamisligil GS. Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis. Mol Cell. 2008 Mar 14; 29(5):541-51. PMID: 18342602.
    Citations: 178     Fields:    Translation:HumansAnimalsCells
  23. Erbay E, Cao H, Hotamisligil GS. Adipocyte/macrophage fatty acid binding proteins in metabolic syndrome. Curr Atheroscler Rep. 2007 Sep; 9(3):222-9. PMID: 18241617.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  24. Liu S, Tinker L, Song Y, Rifai N, Bonds DE, Cook NR, Heiss G, Howard BV, Hotamisligil GS, Hu FB, Kuller LH, Manson JE. A prospective study of inflammatory cytokines and diabetes mellitus in a multiethnic cohort of postmenopausal women. Arch Intern Med. 2007 Aug 13-27; 167(15):1676-85. PMID: 17698692.
    Citations: 56     Fields:    Translation:Humans
  25. Reynolds JM, Liu Q, Brittingham KC, Liu Y, Gruenthal M, Gorgun CZ, Hotamisligil GS, Stout RD, Suttles J. Deficiency of fatty acid-binding proteins in mice confers protection from development of experimental autoimmune encephalomyelitis. J Immunol. 2007 Jul 01; 179(1):313-21. PMID: 17579051.
    Citations: 29     Fields:    Translation:AnimalsCells
  26. Furuhashi M, Tuncman G, Görgün CZ, Makowski L, Atsumi G, Vaillancourt E, Kono K, Babaev VR, Fazio S, Linton MF, Sulsky R, Robl JA, Parker RA, Hotamisligil GS. Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2. Nature. 2007 Jun 21; 447(7147):959-65. PMID: 17554340.
    Citations: 175     Fields:    Translation:HumansAnimalsCells
  27. Gregor MG, Hotamisligil GS. Adipocyte stress: The endoplasmic reticulum and metabolic disease. J Lipid Res. 2007 May 9. PMID: 17494945.
    Citations:    
  28. Gregor MF, Hotamisligil GS. Thematic review series: Adipocyte Biology. Adipocyte stress: the endoplasmic reticulum and metabolic disease. J Lipid Res. 2007 Sep; 48(9):1905-14. PMID: 17699733.
    Citations: 154     Fields:    Translation:HumansAnimalsCells
  29. Wellen KE, Fucho R, Gregor MF, Furuhashi M, Morgan C, Lindstad T, Vaillancourt E, Gorgun CZ, Saatcioglu F, Hotamisligil GS. Coordinated regulation of nutrient and inflammatory responses by STAMP2 is essential for metabolic homeostasis. Cell. 2007 May 04; 129(3):537-48. PMID: 17482547.
    Citations: 51     Fields:    Translation:AnimalsCells
  30. Song Y, Manson JE, Tinker L, Rifai N, Cook NR, Hu FB, Hotamisligil GS, Ridker PM, Rodriguez BL, Margolis KL, Oberman A, Liu S. Circulating levels of endothelial adhesion molecules and risk of diabetes in an ethnically diverse cohort of women. Diabetes. 2007 Jul; 56(7):1898-904. PMID: 17389327.
    Citations: 53     Fields:    Translation:Humans
  31. Tong Q, Hotamisligil GS. Developmental biology: cell fate in the mammary gland. Nature. 2007 Feb 15; 445(7129):724-6. PMID: 17301782.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  32. Hotamisligil GS. Endoplasmic reticulum stress and inflammation in obesity and type 2 diabetes. Novartis Found Symp. 2007; 286:86-94; discussion 94-8, 162-3, 196-203. PMID: 18269176.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  33. Hotamisligil GS. Inflammation and metabolic disorders. Nature. 2006 Dec 14; 444(7121):860-7. PMID: 17167474.
    Citations: 1966     Fields:    Translation:HumansAnimals
  34. Steinberg GR, Michell BJ, van Denderen BJ, Watt MJ, Carey AL, Fam BC, Andrikopoulos S, Proietto J, Görgün CZ, Carling D, Hotamisligil GS, Febbraio MA, Kay TW, Kemp BE. Tumor necrosis factor alpha-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling. Cell Metab. 2006 Dec; 4(6):465-74. PMID: 17141630.
    Citations: 129     Fields:    Translation:AnimalsCells
  35. Rolph MS, Young TR, Shum BO, Gorgun CZ, Schmitz-Peiffer C, Ramshaw IA, Hotamisligil GS, Mackay CR. Regulation of dendritic cell function and T cell priming by the fatty acid-binding protein AP2. J Immunol. 2006 Dec 01; 177(11):7794-801. PMID: 17114450.
    Citations: 28     Fields:    Translation:AnimalsCells
  36. Witczak CA, Hirshman MF, Jessen N, Fujii N, Seifert MM, Brandauer J, Hotamisligil GS, Goodyear LJ. JNK1 deficiency does not enhance muscle glucose metabolism in lean mice. Biochem Biophys Res Commun. 2006 Dec 01; 350(4):1063-8. PMID: 17045576.
    Citations: 6     Fields:    Translation:Animals
  37. Tilg H, Hotamisligil GS. Nonalcoholic fatty liver disease: Cytokine-adipokine interplay and regulation of insulin resistance. Gastroenterology. 2006 Sep; 131(3):934-45. PMID: 16952562.
    Citations: 76     Fields:    Translation:HumansAnimals
  38. Ozcan U, Yilmaz E, Ozcan L, Furuhashi M, Vaillancourt E, Smith RO, Görgün CZ, Hotamisligil GS. Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science. 2006 Aug 25; 313(5790):1137-40. PMID: 16931765.
    Citations: 778     Fields:    Translation:AnimalsCells
  39. Shum BO, Mackay CR, Gorgun CZ, Frost MJ, Kumar RK, Hotamisligil GS, Rolph MS. The adipocyte fatty acid-binding protein aP2 is required in allergic airway inflammation. J Clin Invest. 2006 Aug; 116(8):2183-2192. PMID: 16841093.
    Citations: 48     Fields:    Translation:AnimalsCells
  40. Bence KK, Delibegovic M, Xue B, Gorgun CZ, Hotamisligil GS, Neel BG, Kahn BB. Neuronal PTP1B regulates body weight, adiposity and leptin action. Nat Med. 2006 Aug; 12(8):917-24. PMID: 16845389.
    Citations: 183     Fields:    Translation:AnimalsCells
  41. Tuncman G, Hirosumi J, Solinas G, Chang L, Karin M, Hotamisligil GS. Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance. Proc Natl Acad Sci U S A. 2006 Jul 11; 103(28):10741-6. PMID: 16818881.
    Citations: 109     Fields:    Translation:HumansAnimalsCells
  42. Cao H, Maeda K, Gorgun CZ, Kim HJ, Park SY, Shulman GI, Kim JK, Hotamisligil GS. Regulation of metabolic responses by adipocyte/macrophage Fatty Acid-binding proteins in leptin-deficient mice. Diabetes. 2006 Jul; 55(7):1915-22. PMID: 16804058.
    Citations: 28     Fields:    Translation:AnimalsCells
  43. Sankalé JL, Tong Q, Hadigan CM, Tan G, Grinspoon SK, Kanki PJ, Hotamisligil GS. Regulation of adiponectin in adipocytes upon exposure to HIV-1. HIV Med. 2006 May; 7(4):268-74. PMID: 16630040.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  44. Tuncman G, Erbay E, Hom X, De Vivo I, Campos H, Rimm EB, Hotamisligil GS. A genetic variant at the fatty acid-binding protein aP2 locus reduces the risk for hypertriglyceridemia, type 2 diabetes, and cardiovascular disease. Proc Natl Acad Sci U S A. 2006 May 02; 103(18):6970-5. PMID: 16641093.
    Citations: 74     Fields:    Translation:HumansAnimalsCells
  45. Baumgartl J, Baudler S, Scherner M, Babaev V, Makowski L, Suttles J, McDuffie M, Tobe K, Kadowaki T, Fazio S, Kahn CR, Hotamisligil GS, Krone W, Linton M, Brüning JC. Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis. Cell Metab. 2006 Apr; 3(4):247-56. PMID: 16581002.
    Citations: 36     Fields:    Translation:AnimalsCells
  46. Neels JG, Pandey M, Hotamisligil GS, Samad F. Autoamplification of tumor necrosis factor-alpha: a potential mechanism for the maintenance of elevated tumor necrosis factor-alpha in male but not female obese mice. Am J Pathol. 2006 Feb; 168(2):435-44. PMID: 16436658.
    Citations: 7     Fields:    Translation:AnimalsCells
  47. Hotamisligil GS. Role of endoplasmic reticulum stress and c-Jun NH2-terminal kinase pathways in inflammation and origin of obesity and diabetes. Diabetes. 2005 Dec; 54 Suppl 2:S73-8. PMID: 16306344.
    Citations: 98     Fields:    Translation:HumansCells
  48. Makowski L, Hotamisligil GS. The role of fatty acid binding proteins in metabolic syndrome and atherosclerosis. Curr Opin Lipidol. 2005 Oct; 16(5):543-8. PMID: 16148539.
    Citations: 58     Fields:    Translation:HumansAnimals
  49. Tsai J, Tong Q, Tan G, Chang AN, Orkin SH, Hotamisligil GS. The transcription factor GATA2 regulates differentiation of brown adipocytes. . 2005 Sep; 6(9):879-84. PMID: 16082385.
    Citations: 6     Fields:    Translation:AnimalsCells
  50. Wellen KE, Hotamisligil GS. Inflammation, stress, and diabetes. J Clin Invest. 2005 May; 115(5):1111-9. PMID: 15864338.
    Citations: 939     Fields:    Translation:HumansAnimalsCells
  51. Ellison MA, Hotamisligil S, Lee H, Rich-Edwards JW, Pang SC, Hall JE. Psychosocial risks associated with multiple births resulting from assisted reproduction. Fertil Steril. 2005 May; 83(5):1422-8. PMID: 15866579.
    Citations: 10     Fields:    Translation:Humans
  52. Pischon T, Girman CJ, Rifai N, Hotamisligil GS, Rimm EB. Association between dietary factors and plasma adiponectin concentrations in men. Am J Clin Nutr. 2005 Apr; 81(4):780-6. PMID: 15817852.
    Citations: 30     Fields:    Translation:Humans
  53. Maeda K, Cao H, Kono K, Gorgun CZ, Furuhashi M, Uysal KT, Cao Q, Atsumi G, Malone H, Krishnan B, Minokoshi Y, Kahn BB, Parker RA, Hotamisligil GS. Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes. Cell Metab. 2005 Feb; 1(2):107-19. PMID: 16054052.
    Citations: 137     Fields:    Translation:AnimalsCells
  54. Makowski L, Brittingham KC, Reynolds JM, Suttles J, Hotamisligil GS. The fatty acid-binding protein, aP2, coordinates macrophage cholesterol trafficking and inflammatory activity. Macrophage expression of aP2 impacts peroxisome proliferator-activated receptor gamma and IkappaB kinase activities. J Biol Chem. 2005 Apr 01; 280(13):12888-95. PMID: 15684432.
    Citations: 102     Fields:    Translation:AnimalsCells
  55. Tong Q, Tsai J, Tan G, Dalgin G, Hotamisligil GS. Interaction between GATA and the C/EBP family of transcription factors is critical in GATA-mediated suppression of adipocyte differentiation. Mol Cell Biol. 2005 Jan; 25(2):706-15. PMID: 15632071.
    Citations: 67     Fields:    Translation:HumansAnimalsCells
  56. Ozcan U, Cao Q, Yilmaz E, Lee AH, Iwakoshi NN, Ozdelen E, Tuncman G, Görgün C, Glimcher LH, Hotamisligil GS. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science. 2004 Oct 15; 306(5695):457-61. PMID: 15486293.
    Citations: 1017     Fields:    Translation:AnimalsCells
  57. Boord JB, Maeda K, Makowski L, Babaev VR, Fazio S, Linton MF, Hotamisligil GS. Combined adipocyte-macrophage fatty acid-binding protein deficiency improves metabolism, atherosclerosis, and survival in apolipoprotein E-deficient mice. Circulation. 2004 Sep 14; 110(11):1492-8. PMID: 15353487.
    Citations: 48     Fields:    Translation:Animals
  58. Makowski L, Hotamisligil GS. Fatty acid binding proteins--the evolutionary crossroads of inflammatory and metabolic responses. J Nutr. 2004 Sep; 134(9):2464S-2468S. PMID: 15333743.
    Citations: 64     Fields:    Translation:HumansAnimals
  59. Pischon T, Girman CJ, Hotamisligil GS, Rifai N, Hu FB, Rimm EB. Plasma adiponectin levels and risk of myocardial infarction in men. JAMA. 2004 Apr 14; 291(14):1730-7. PMID: 15082700.
    Citations: 370     Fields:    Translation:Humans
  60. Wellen KE, Uysal KT, Wiesbrock S, Yang Q, Chen H, Hotamisligil GS. Interaction of tumor necrosis factor-alpha- and thiazolidinedione-regulated pathways in obesity. Endocrinology. 2004 May; 145(5):2214-20. PMID: 14764635.
    Citations: 13     Fields:    Translation:Animals
  61. Hotamisligil GS. Inflammatory pathways and insulin action. Int J Obes Relat Metab Disord. 2003 Dec; 27 Suppl 3:S53-5. PMID: 14704746.
    Citations: 144     Fields:    Translation:HumansAnimalsCells
  62. Wellen KE, Hotamisligil GS. Obesity-induced inflammatory changes in adipose tissue. J Clin Invest. 2003 Dec; 112(12):1785-8. PMID: 14679172.
    Citations: 425     Fields:    Translation:HumansAnimalsCells
  63. Tong Q, Tsai J, Hotamisligil GS. GATA transcription factors and fat cell formation. Drug News Perspect. 2003 Nov; 16(9):585-8. PMID: 14702139.
    Citations: 7     Fields:    Translation:AnimalsCells
  64. Pischon T, Hankinson SE, Hotamisligil GS, Rifai N, Rimm EB. Leisure-time physical activity and reduced plasma levels of obesity-related inflammatory markers. Obes Res. 2003 Sep; 11(9):1055-64. PMID: 12972675.
    Citations: 43     Fields:    Translation:Humans
  65. Pischon T, Hankinson SE, Hotamisligil GS, Rifai N, Willett WC, Rimm EB. Habitual dietary intake of n-3 and n-6 fatty acids in relation to inflammatory markers among US men and women. Circulation. 2003 Jul 15; 108(2):155-60. PMID: 12821543.
    Citations: 116     Fields:    Translation:Humans
  66. Tong Q, Sankalé JL, Hadigan CM, Tan G, Rosenberg ES, Kanki PJ, Grinspoon SK, Hotamisligil GS. Regulation of adiponectin in human immunodeficiency virus-infected patients: relationship to body composition and metabolic indices. J Clin Endocrinol Metab. 2003 Apr; 88(4):1559-64. PMID: 12679439.
    Citations: 21     Fields:    Translation:Humans
  67. Pischon T, Hotamisligil GS, Rimm EB. Adiponectin: stability in plasma over 36 hours and within-person variation over 1 year. Clin Chem. 2003 Apr; 49(4):650-2. PMID: 12651819.
    Citations: 49     Fields:    Translation:Humans
  68. Pandey M, Tuncman G, Hotamisligil GS, Samad F. Divergent roles for p55 and p75 TNF-alpha receptors in the induction of plasminogen activator inhibitor-1. Am J Pathol. 2003 Mar; 162(3):933-41. PMID: 12598326.
    Citations: 7     Fields:    Translation:AnimalsCells
  69. Maeda K, Uysal KT, Makowski L, Görgün CZ, Atsumi G, Parker RA, Brüning J, Hertzel AV, Bernlohr DA, Hotamisligil GS. Role of the fatty acid binding protein mal1 in obesity and insulin resistance. Diabetes. 2003 Feb; 52(2):300-7. PMID: 12540600.
    Citations: 62     Fields:    Translation:AnimalsCells
  70. Hotamisligil GS. The irresistible biology of resistin. J Clin Invest. 2003 Jan; 111(2):173-4. PMID: 12531870.
    Citations: 13     Fields:    Translation:Animals
  71. Hirosumi J, Tuncman G, Chang L, Görgün CZ, Uysal KT, Maeda K, Karin M, Hotamisligil GS. A central role for JNK in obesity and insulin resistance. Nature. 2002 Nov 21; 420(6913):333-6. PMID: 12447443.
    Citations: 889     Fields:    Translation:AnimalsCells
  72. Fisher RM, Hoffstedt J, Hotamisligil GS, Thörne A, Rydén M. Effects of obesity and weight loss on the expression of proteins involved in fatty acid metabolism in human adipose tissue. Int J Obes Relat Metab Disord. 2002 Oct; 26(10):1379-85. PMID: 12355335.
    Citations: 6     Fields:    Translation:Humans
  73. Boord JB, Maeda K, Makowski L, Babaev VR, Fazio S, Linton MF, Hotamisligil GS. Adipocyte fatty acid-binding protein, aP2, alters late atherosclerotic lesion formation in severe hypercholesterolemia. Arterioscler Thromb Vasc Biol. 2002 Oct 01; 22(10):1686-91. PMID: 12377750.
    Citations: 48     Fields:    Translation:Animals
  74. Xu H, Uysal KT, Becherer JD, Arner P, Hotamisligil GS. Altered tumor necrosis factor-alpha (TNF-alpha) processing in adipocytes and increased expression of transmembrane TNF-alpha in obesity. Diabetes. 2002 Jun; 51(6):1876-83. PMID: 12031976.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  75. Xu H, Hirosumi J, Uysal KT, Guler AD, Hotamisligil GS. Exclusive action of transmembrane TNF alpha in adipose tissue leads to reduced adipose mass and local but not systemic insulin resistance. Endocrinology. 2002 Apr; 143(4):1502-11. PMID: 11897709.
    Citations: 32     Fields:    Translation:AnimalsCells
  76. Chiellini C, Bertacca A, Novelli SE, Görgün CZ, Ciccarone A, Giordano A, Xu H, Soukas A, Costa M, Gandini D, Dimitri R, Bottone P, Cecchetti P, Pardini E, Perego L, Navalesi R, Folli F, Benzi L, Cinti S, Friedman JM, Hotamisligil GS, Maffei M. Obesity modulates the expression of haptoglobin in the white adipose tissue via TNFalpha. J Cell Physiol. 2002 Feb; 190(2):251-8. PMID: 11807829.
    Citations: 15     Fields:    Translation:AnimalsCells
  77. Mohamed-Ali V, Flower L, Sethi J, Hotamisligil G, Gray R, Humphries SE, York DA, Pinkney J. beta-Adrenergic regulation of IL-6 release from adipose tissue: in vivo and in vitro studies. J Clin Endocrinol Metab. 2001 Dec; 86(12):5864-9. PMID: 11739453.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  78. Emanuelli B, Peraldi P, Filloux C, Chavey C, Freidinger K, Hilton DJ, Hotamisligil GS, Van Obberghen E. SOCS-3 inhibits insulin signaling and is up-regulated in response to tumor necrosis factor-alpha in the adipose tissue of obese mice. J Biol Chem. 2001 Dec 21; 276(51):47944-9. PMID: 11604392.
    Citations: 120     Fields:    Translation:AnimalsCells
  79. Xu H, Hotamisligil GS. Signaling pathways utilized by tumor necrosis factor receptor 1 in adipocytes to suppress differentiation. FEBS Lett. 2001 Oct 05; 506(2):97-102. PMID: 11591379.
    Citations: 6     Fields:    Translation:AnimalsCells
  80. Tong Q, Hotamisligil GS. Molecular mechanisms of adipocyte differentiation. Rev Endocr Metab Disord. 2001 Oct; 2(4):349-55. PMID: 11725721.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  81. Fisher RM, Eriksson P, Hoffstedt J, Hotamisligil GS, Thörne A, Rydén M, Hamsten A, Arner P. Fatty acid binding protein expression in different adipose tissue depots from lean and obese individuals. Diabetologia. 2001 Oct; 44(10):1268-73. PMID: 11692175.
    Citations: 18     Fields:    Translation:Humans
  82. Chu NF, Spiegelman D, Hotamisligil GS, Rifai N, Stampfer M, Rimm EB. Plasma insulin, leptin, and soluble TNF receptors levels in relation to obesity-related atherogenic and thrombogenic cardiovascular disease risk factors among men. Atherosclerosis. 2001 Aug; 157(2):495-503. PMID: 11472752.
    Citations: 23     Fields:    Translation:Humans
  83. Makowski L, Boord JB, Maeda K, Babaev VR, Uysal KT, Morgan MA, Parker RA, Suttles J, Fazio S, Hotamisligil GS, Linton MF. Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis. Nat Med. 2001 Jun; 7(6):699-705. PMID: 11385507.
    Citations: 195     Fields:    Translation:HumansAnimalsCells
  84. Way JM, Görgün CZ, Tong Q, Uysal KT, Brown KK, Harrington WW, Oliver WR, Willson TM, Kliewer SA, Hotamisligil GS. Adipose tissue resistin expression is severely suppressed in obesity and stimulated by peroxisome proliferator-activated receptor gamma agonists. J Biol Chem. 2001 Jul 13; 276(28):25651-3. PMID: 11373275.
    Citations: 52     Fields:    Translation:AnimalsCells
  85. Chu NF, Spiegelman D, Yu J, Rifai N, Hotamisligil GS, Rimm EB. Plasma leptin concentrations and four-year weight gain among US men. Int J Obes Relat Metab Disord. 2001 Mar; 25(3):346-53. PMID: 11319631.
    Citations: 11     Fields:    Translation:Humans
  86. Chu NF, Stampfer MJ, Spiegelman D, Rifai N, Hotamisligil GS, Rimm EB. Dietary and lifestyle factors in relation to plasma leptin concentrations among normal weight and overweight men. Int J Obes Relat Metab Disord. 2001 Jan; 25(1):106-14. PMID: 11244465.
    Citations: 18     Fields:    Translation:Humans
  87. Hotamisligil GS. Molecular mechanisms of insulin resistance and the role of the adipocyte. Int J Obes Relat Metab Disord. 2000 Nov; 24 Suppl 4:S23-7. PMID: 11126235.
    Citations: 41     Fields:    Translation:AnimalsCells
  88. Tong Q, Dalgin G, Xu H, Ting CN, Leiden JM, Hotamisligil GS. Function of GATA transcription factors in preadipocyte-adipocyte transition. Science. 2000 Oct 06; 290(5489):134-8. PMID: 11021798.
    Citations: 137     Fields:    Translation:AnimalsCells
  89. Chu NF, Spiegelman D, Rifai N, Hotamisligil GS, Rimm EB. Glycemic status and soluble tumor necrosis factor receptor levels in relation to plasma leptin concentrations among normal weight and overweight US men. Int J Obes Relat Metab Disord. 2000 Sep; 24(9):1085-92. PMID: 11033975.
    Citations: 12     Fields:    Translation:Humans
  90. Uysal KT, Scheja L, Wiesbrock SM, Bonner-Weir S, Hotamisligil GS. Improved glucose and lipid metabolism in genetically obese mice lacking aP2. Endocrinology. 2000 Sep; 141(9):3388-96. PMID: 10965911.
    Citations: 70     Fields:    Translation:AnimalsCells
  91. Nisoli E, Briscini L, Giordano A, Tonello C, Wiesbrock SM, Uysal KT, Cinti S, Carruba MO, Hotamisligil GS. Tumor necrosis factor alpha mediates apoptosis of brown adipocytes and defective brown adipocyte function in obesity. Proc Natl Acad Sci U S A. 2000 Jul 05; 97(14):8033-8. PMID: 10884431.
    Citations: 14     Fields:    Translation:AnimalsCells
  92. Sethi JK, Xu H, Uysal KT, Wiesbrock SM, Scheja L, Hotamisligil GS. Characterisation of receptor-specific TNFalpha functions in adipocyte cell lines lacking type 1 and 2 TNF receptors. FEBS Lett. 2000 Mar 03; 469(1):77-82. PMID: 10708760.
    Citations: 24     Fields:    Translation:AnimalsCells
  93. Memon RA, Hotamisligil GS, Wiesbrock SM, Uysal KT, Faggioni R, Moser AH, Feingold KR, Grunfeld C. Upregulation of uncoupling protein 2 mRNA in genetic obesity: lack of an essential role for leptin, hyperphagia, increased tissue lipid content, and TNF-alpha. Biochim Biophys Acta. 2000 Feb 24; 1484(1):41-50. PMID: 10685029.
    Citations: 4     Fields:    Translation:AnimalsCells
  94. Scheja L, Makowski L, Uysal KT, Wiesbrock SM, Shimshek DR, Meyers DS, Morgan M, Parker RA, Hotamisligil GS. Altered insulin secretion associated with reduced lipolytic efficiency in aP2-/- mice. Diabetes. 1999 Oct; 48(10):1987-94. PMID: 10512363.
    Citations: 42     Fields:    Translation:AnimalsCells
  95. Xu H, Sethi JK, Hotamisligil GS. Transmembrane tumor necrosis factor (TNF)-alpha inhibits adipocyte differentiation by selectively activating TNF receptor 1. J Biol Chem. 1999 Sep 10; 274(37):26287-95. PMID: 10473584.
    Citations: 34     Fields:    Translation:AnimalsCells
  96. Samad F, Uysal KT, Wiesbrock SM, Pandey M, Hotamisligil GS, Loskutoff DJ. Tumor necrosis factor alpha is a key component in the obesity-linked elevation of plasminogen activator inhibitor 1. Proc Natl Acad Sci U S A. 1999 Jun 08; 96(12):6902-7. PMID: 10359811.
    Citations: 34     Fields:    Translation:Animals
  97. Hotamisligil GS. The role of TNFalpha and TNF receptors in obesity and insulin resistance. J Intern Med. 1999 Jun; 245(6):621-5. PMID: 10395191.
    Citations: 127     Fields:    Translation:HumansAnimals
  98. Chu NF, Makowski L, Hotamisligil GS, Rimm EB. Stability of human plasma leptin concentrations within 36 hours following specimen collection. Clin Biochem. 1999 Feb; 32(1):87-9. PMID: 10074899.
    Citations:    Fields:    Translation:Humans
  99. Sethi JK, Hotamisligil GS. The role of TNF alpha in adipocyte metabolism. Semin Cell Dev Biol. 1999 Feb; 10(1):19-29. PMID: 10355025.
    Citations: 73     Fields:    Translation:HumansAnimalsCells
  100. Hotamisligil GS. Mechanisms of TNF-alpha-induced insulin resistance. Exp Clin Endocrinol Diabetes. 1999; 107(2):119-25. PMID: 10320052.
    Citations: 90     Fields:    Translation:HumansAnimals
  101. Uysal KT, Wiesbrock SM, Hotamisligil GS. Functional analysis of tumor necrosis factor (TNF) receptors in TNF-alpha-mediated insulin resistance in genetic obesity. Endocrinology. 1998 Dec; 139(12):4832-8. PMID: 9832419.
    Citations: 42     Fields:    Translation:Animals
  102. Kirchgessner TG, Uysal KT, Wiesbrock SM, Marino MW, Hotamisligil GS. Tumor necrosis factor-alpha contributes to obesity-related hyperleptinemia by regulating leptin release from adipocytes. J Clin Invest. 1997 Dec 01; 100(11):2777-82. PMID: 9389742.
    Citations: 51     Fields:    Translation:AnimalsCells
  103. Uysal KT, Wiesbrock SM, Marino MW, Hotamisligil GS. Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature. 1997 Oct 09; 389(6651):610-4. PMID: 9335502.
    Citations: 498     Fields:    Translation:AnimalsCells
  104. Hotamisligil GS, Arner P, Atkinson RL, Spiegelman BM. Differential regulation of the p80 tumor necrosis factor receptor in human obesity and insulin resistance. Diabetes. 1997 Mar; 46(3):451-5. PMID: 9032102.
    Citations: 24     Fields:    Translation:Humans
  105. Hotamisligil GS, Johnson RS, Distel RJ, Ellis R, Papaioannou VE, Spiegelman BM. Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein. Science. 1996 Nov 22; 274(5291):1377-9. PMID: 8910278.
    Citations: 202     Fields:    Translation:Animals
  106. Hotamisligil S, Toner M, Powers RD. Changes in membrane integrity, cytoskeletal structure, and developmental potential of murine oocytes after vitrification in ethylene glycol. Biol Reprod. 1996 Jul; 55(1):161-8. PMID: 8793071.
    Citations: 11     Fields:    Translation:AnimalsCells
  107. Peraldi P, Hotamisligil GS, Buurman WA, White MF, Spiegelman BM. Tumor necrosis factor (TNF)-alpha inhibits insulin signaling through stimulation of the p55 TNF receptor and activation of sphingomyelinase. J Biol Chem. 1996 May 31; 271(22):13018-22. PMID: 8662983.
    Citations: 74     Fields:    Translation:HumansAnimalsCells
  108. Hotamisligil GS, Peraldi P, Budavari A, Ellis R, White MF, Spiegelman BM. IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance. Science. 1996 Feb 02; 271(5249):665-8. PMID: 8571133.
    Citations: 481     Fields:    Translation:AnimalsCells
  109. Hotamisligil GS, Arner P, Caro JF, Atkinson RL, Spiegelman BM. Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J Clin Invest. 1995 May; 95(5):2409-15. PMID: 7738205.
    Citations: 610     Fields:    Translation:Humans
  110. Hotamisligil GS, Spiegelman BM. Tumor necrosis factor alpha: a key component of the obesity-diabetes link. Diabetes. 1994 Nov; 43(11):1271-8. PMID: 7926300.
    Citations: 197     Fields:    Translation:HumansAnimals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.