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Igor Kissin, PH.D., M.D.

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Overview
My research encompasses both basic and clinical research: cardiovascular pharmacology, general anesthetic action, local anesthesia, opioid pharmacology, postoperative analgesia, treatment of chronic pain, pharmacology of vanilloid agonists, and assessment of medical research using specific publication-based indices. Here are several highlights:

I developed (1981-1993) the concept that general anesthesia is based not on a single general anesthetic action but on a spectrum of separate pharmacological actions, even if only one drug is used. As a result, the characteristics of an anesthetic agent depend on the relative strength of various independent actions that constitute the components of anesthesia (unconsciousness, absence of movement in response to noxious stimulation, attenuation of autonomic responses, etc.). The development of this concept led to the conclusion that the search for a reliable index of anesthetic depth should be focused on separate indices of the distinct components of anesthesia.

One area of my investigations is preemptive analgesia (1990-2002), an intervention which prevents establishment of the altered sensory processing that amplifies post-operative pain. We identified the most important condition for maximizing the preemptive effect: the treatment should cover the entire duration of high-intensity noxious stimulation that can lead to establishment of sensitization including the initial postoperative period. As a result, we suggested the adoption of a different term – “preventive analgesia”.

We demonstrated (1991-1998) that acute tolerance to opioid analgesia can develop very rapidly and that this phenomenon carries over into humans, especially with short-acting opioids such as remifentanil.

We also demonstrated (1994-1998) that intrathecally administered local anesthetics decrease hypnotic requirements for general anesthetics (and for antinociception above the level of spinal blockade), mostly due to decreased afferent input.

We have found (2002-2009) that perineural administration of the vanilloid (TRPV1) agonist resiniferatoxin prevents hyperalgesia in a rat model of postoperative pain. An electron microscopy study in rats also demonstrated that resiniferatoxin-induced sciatic nerve blockade may produce morphological changes in C fibers, but to a much smaller degree than local anesthetics. This result opens a new avenue in the treatment of pain: to use nerve blockade for selective analgesia, analgesia without suppressing motor or sensory functions unrelated to pain.

We opened (2011-2016) a new area of scientometrics (studies on quantitative aspects of science): the assessment of medical research using specific publication-based indices. This direction belongs to a category of big data analytics.

Presently (2017-2018) we are concentrating on the following topic: "Stagnation in the research related to the pharmacological basis of anesthesia." To assess this problem we are combining three approaches: scientometric analysis of changes in academic interest in this field, assessment of the degree of novelty of new drugs and drug candidates for general and regional anesthesia, and evaluation of advances reported in pertinent meta-analyses.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01GM065834 (KISSIN, IGOR) Apr 1, 2004 - Mar 31, 2010
    NIH/NIGMS
    Neural blockade with vanilloids
    Role: Principal Investigator
  2. R01GM039344 (KISSIN, IGOR) Apr 1, 1989 - Mar 31, 1995
    NIH/NIGMS
    MODULATION OF ANESTHETIC ACTION OF BENZODIAZEPINES
    Role: Principal Investigator
  3. R01GM035135 (KISSIN, IGOR) Sep 1, 1985 - Sep 29, 2003
    NIH/NIGMS
    ACUTE TOLERANCE IN ANESTHETIC ACTIONS AND INTERACTIONS
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Kissin I, Vlassakov KV. Pharmacological Basis of Anesthesia: How to Overcome Stagnation? Anesth Analg. 2018 Apr 19. PMID: 29683831.
    View in: PubMed
  2. Kissin I. What Can Big Data on Academic Interest Reveal about a Drug? Reflections in Three Major US Databases. Trends Pharmacol Sci. 2018 Mar; 39(3):248-257. PMID: 29358009.
    View in: PubMed
  3. Correll DJ, Kissin I. Publication-Based Academic Interest in Drugs and Techniques for Treatment of Postoperative Pain, 1975-2015. J Anesth Hist. 2017 Oct; 3(4):122-127. PMID: 29275803.
    View in: PubMed
  4. Vlassakov KV, Kissin I. Assessing advances in regional anesthesia by their portrayals in meta-analyses: an alternative view on recent progress. BMC Anesthesiol. 2017 Aug 29; 17(1):112. PMID: 28851295.
    View in: PubMed
  5. Vlassakov KV, Kissin I. Trends in Academic Interest Indicate a Constantly Declining Choice of Anesthetics: In Response to Dhillon and Butterworth. J Anesth Hist. 2016 Oct; 2(4):151-152. PMID: 27852464.
    View in: PubMed
  6. Kissin I. Opioid prescriptions for pain and epidemic of overdose death: can the dramatic reduction in anesthesia mortality serve as an example? J Pain Res. 2016; 9:453-6. PMID: 27418852; PMCID: PMC4935029.
  7. Vlassakov KV, Kissin I. Changes in Publication-Based Academic Interest in Local Anesthetics Over the Past 50 Years. J Anesth Hist. 2016 Jul; 2(3):73-8. PMID: 27480472.
    View in: PubMed
  8. Vlassakov KV, Kissin I. Decline in the Development of New Anesthetics. Trends Pharmacol Sci. 2016 05; 37(5):344-352. PMID: 26922254.
    View in: PubMed
  9. Kissin I. Scientometrics of drug discovery efforts: pain-related molecular targets. Drug Des Devel Ther. 2015; 9:3393-404. PMID: 26170624; PMCID: PMC4492640.
  10. Vlassakov KV, Kissin I. A quest to increase safety of anesthetics by advancements in anesthesia monitoring: scientometric analysis. Drug Des Devel Ther. 2015; 9:2599-608. PMID: 26005336; PMCID: PMC4433046.
  11. Vlassakov KV, Kissin I. Scientometrics of anesthetic drugs and their techniques of administration, 1984-2013. Drug Des Devel Ther. 2014; 8:2463-73. PMID: 25525336; PMCID: PMC4267516.
  12. Kissin I. Scientometric assessment of drugs for chronic pain, 1979-2013: rapid growth of publications, paucity of successful drugs. J Pain Res. 2014; 7:505-14. PMID: 25187736; PMCID: PMC4149448.
  13. Correll DJ, Vlassakov KV, Kissin I. No evidence of real progress in treatment of acute pain, 1993-2012: scientometric analysis. J Pain Res. 2014; 7:199-210. PMID: 24748816; PMCID: PMC3990387.
  14. Kissin I. Long-term opioid treatment of chronic nonmalignant pain: unproven efficacy and neglected safety? J Pain Res. 2013; 6:513-29. PMID: 23874119; PMCID: PMC3712997.
  15. Kissin I. An early indicator of drug success: Top Journal Selectivity Index. Drug Des Devel Ther. 2013; 7:93-8. PMID: 23430968; PMCID: PMC3575128.
  16. Kissin I, Bradley Jr. EL. Migration of scientists to novel areas of biomedical research: Role of article-related productivity. J Scientometric Res. 2013; 2(3):206 - 213.
  17. Kissin I, Gelman S. Chronic postsurgical pain: still a neglected topic? J Pain Res. 2012; 5:473-89. PMID: 23152698; PMCID: PMC3496527.
  18. Kissin I. How does the lidocaine patch (5%) relieve pain? Pain. 2012 Jun; 153(6):1332-3. PMID: 22494921.
    View in: PubMed
  19. Vlassakov KV, Narang S, Kissin I. Cutaneous anesthesia in neuropathic pain: Systematic analysis. J Anesth Clin Res. 2012; 3(3):1000199.
  20. Kissin I, Bradley EL Jr. Top Journal Selectivity Index and "me-too" drugs. Scientometrics. 2012; 91(1):131-42.
  21. Kissin I. A call to reassess the clinical value of preventive (preemptive) analgesia. Anesth Analg. 2011 Nov; 113(5):977-8. PMID: 22021795.
    View in: PubMed
  22. Kissin I, Bradley EL Jr. Top Journal Selectivity Index: Is it acceptable for drugs beyond the field of analgesia? Scientometrics. 2011; 88(2):589- 97.
  23. Kissin I. Can a bibliometric indicator predict the success of an analgesic? Scientometrics. 2011; 86(3):785-95.
  24. Vlassakov KV, Narang S, Kissin I. Local anesthetic blockade of peripheral nerves for treatment of neuralgias: systematic analysis. Anesth Analg. 2011 Jun; 112(6):1487-93. PMID: 21372279.
    View in: PubMed
  25. Kissin I, Szallasi A. Therapeutic targeting of TRPV1 by resiniferatoxin, from preclinical studies to clinical trials. Curr Top Med Chem. 2011; 11(17):2159-70. PMID: 21671878.
    View in: PubMed
  26. Kissin I. The development of new analgesics over the past 50 years: a lack of real breakthrough drugs. Anesth Analg. 2010 Mar 01; 110(3):780-9. PMID: 20185657.
    View in: PubMed
  27. Kissin I. Preemptive analgesia: problems with assessment of clinical significance. Methods Mol Biol. 2010; 617:475-82. PMID: 20336442.
    View in: PubMed
  28. Kissin I. Patient-controlled-analgesia analgesimetry and its problems. Anesth Analg. 2009 Jun; 108(6):1945-9. PMID: 19448227.
    View in: PubMed
  29. Sugimoto K, Kissin I, Strichartz G. A high concentration of resiniferatoxin inhibits ion channel function in clonal neuroendocrine cells. Anesth Analg. 2008 Jul; 107(1):318-24. PMID: 18635503.
    View in: PubMed
  30. Kissin I. Vanilloid-induced conduction analgesia: selective, dose-dependent, long-lasting, with a low level of potential neurotoxicity. Anesth Analg. 2008 Jul; 107(1):271-81. PMID: 18635498; PMCID: PMC2497455.
  31. Yukhananov R, Kissin I. Persistent changes in spinal cord gene expression after recovery from inflammatory hyperalgesia: a preliminary study on pain memory. BMC Neurosci. 2008 Mar 13; 9:32. PMID: 18366630; PMCID: PMC2315656.
  32. Kissin I, Freitas CF, Mulhern HL, DeGirolami U. Sciatic nerve block with resiniferatoxin: an electron microscopic study of unmyelinated fibers in the rat. Anesth Analg. 2007 Sep; 105(3):825-31. PMID: 17717246.
    View in: PubMed
  33. Kissin I, Freitas CF, Bradley EL. Perineural resiniferatoxin prevents the development of hyperalgesia produced by loose ligation of the sciatic nerve in rats. Anesth Analg. 2007 May; 104(5):1210-6, tables of contents. PMID: 17456676.
    View in: PubMed
  34. Kissin I, Freitas CF, Bradley EL. Memory of pain: the effect of perineural resiniferatoxin. Anesth Analg. 2006 Sep; 103(3):721-8. PMID: 16931687.
    View in: PubMed
  35. Wasan AD, Correll DJ, Kissin I, O'Shea S, Jamison RN. Iatrogenic addiction in patients treated for acute or subacute pain: a systematic review. J Opioid Manag. 2006 Jan-Feb; 2(1):16-22. PMID: 17319113.
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  36. Kissin I. Tolerance to opioid analgesia: why do we differ from rats? Anesth Analg. 2005 Dec; 101(6):1727-9. PMID: 16301250.
    View in: PubMed
  37. Kissin EY, Freitas CF, Kissin I. The effects of intraarticular resiniferatoxin in experimental knee-joint arthritis. Anesth Analg. 2005 Nov; 101(5):1433-9. PMID: 16244007; PMCID: PMC1409708.
  38. Kissin I, Davison N, Bradley EL. Perineural resiniferatoxin prevents hyperalgesia in a rat model of postoperative pain. Anesth Analg. 2005 Mar; 100(3):774-80, table of contents. PMID: 15728067.
    View in: PubMed
  39. Kissin I. Preemptive analgesia at the crossroad. Anesth Analg. 2005 Mar; 100(3):754-6. PMID: 15728065.
    View in: PubMed
  40. Kissin I, Lee SS. Effects of long-term nerve blockade in the spared nerve injury model. Anesthesiology. 2004 Sep; 101(3):806-7. PMID: 15329619.
    View in: PubMed
  41. Yukhananov RY, Kissin I. Comment on Zeitz, K.P., et al., Reduced development of tolerance to the analgesic effects of morphine and clonidine in PKC mutant mice, PAIN 94 (2002) 245-253. Pain. 2003 Apr; 102(3):309-10; author reply 310-1. PMID: 12670673.
    View in: PubMed
  42. Kissin I, Bright CA, Bradley EL. Selective and long-lasting neural blockade with resiniferatoxin prevents inflammatory pain hypersensitivity. Anesth Analg. 2002 May; 94(5):1253-8, table of contents. PMID: 11973200.
    View in: PubMed
  43. Kissin I. Study design to demonstrate clinical value of preemptive analgesia: is the commonly used approach valid? Reg Anesth Pain Med. 2002 May-Jun; 27(3):242-4. PMID: 12016595.
    View in: PubMed
  44. Kissin I, Bright CA, Bradley EL. Can inflammatory pain prevent the development of acute tolerance to alfentanil? Anesth Analg. 2001 May; 92(5):1296-300. PMID: 11323365.
    View in: PubMed
  45. Kissin I, Bright CA, Bradley EL. The effect of ketamine on opioid-induced acute tolerance: can it explain reduction of opioid consumption with ketamine-opioid analgesic combinations? Anesth Analg. 2000 Dec; 91(6):1483-8. PMID: 11094005.
    View in: PubMed
  46. Kissin I. Preemptive analgesia. Anesthesiology. 2000 Oct; 93(4):1138-43. PMID: 11020772.
    View in: PubMed
  47. Kissin I, Bright CA, Bradley EL. Acute tolerance to continuously infused alfentanil: the role of cholecystokinin and N-methyl-D-aspartate-nitric oxide systems. Anesth Analg. 2000 Jul; 91(1):110-6. PMID: 10866896.
    View in: PubMed
  48. Kissin I. Depth of anesthesia and bispectral index monitoring. Anesth Analg. 2000 May; 90(5):1114-7. PMID: 10781463.
    View in: PubMed
  49. Kissin I, Lee SS, Bradley EL. Hyperalgesia caused by nerve transection: long-lasting block prevents early hyperalgesia in the receptive field of the surviving nerve. Anesth Analg. 1999 Dec; 89(6):1475-81. PMID: 10589632.
    View in: PubMed
  50. Vinik HR, Bradley EL, Kissin I. Isobolographic analysis of propofol-thiopental hypnotic interaction in surgical patients. Anesth Analg. 1999 Mar; 88(3):667-70. PMID: 10072025.
    View in: PubMed
  51. Tverskoy M, Braslavsky A, Mazor A, Ferman R, Kissin I. The peripheral effect of fentanyl on postoperative pain. Anesth Analg. 1998 Nov; 87(5):1121-4. PMID: 9806693.
    View in: PubMed
  52. Vinik HR, Kissin I. Rapid development of tolerance to analgesia during remifentanil infusion in humans. Anesth Analg. 1998 Jun; 86(6):1307-11. PMID: 9620525.
    View in: PubMed
  53. Eappen S, Kissin I. Effect of subarachnoid bupivacaine block on anesthetic requirements for thiopental in rats. Anesthesiology. 1998 Apr; 88(4):1036-42. PMID: 9579513.
    View in: PubMed
  54. Kissin I, Lee SS, Bradley EL. Effect of prolonged nerve block on inflammatory hyperalgesia in rats: prevention of late hyperalgesia. Anesthesiology. 1998 Jan; 88(1):224-32. PMID: 9447876.
    View in: PubMed
  55. Kissin I. Anesthetic interactions following bolus injections. J Clin Anesth. 1997 Sep; 9(6 Suppl):14S-17S. PMID: 9278849.
    View in: PubMed
  56. Kissin I. A concept for assessing interactions of general anesthetics. Anesth Analg. 1997 Jul; 85(1):204-10. PMID: 9212148.
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  57. Kissin I, Lee SS, Arthur GR, Bradley EL. Effect of midazolam on development of acute tolerance to alfentanil: the role of pharmacokinetic interactions. Anesth Analg. 1997 Jul; 85(1):182-7. PMID: 9212144.
    View in: PubMed
  58. Choi RH, Birknes JK, Popitz-Bergez FA, Kissin I, Strichartz GR. Pharmacokinetic nature of tachyphylaxis to lidocaine: peripheral nerve blocks and infiltration anesthesia in rats. Life Sci. 1997; 61(12):PL 177-84. PMID: 9315513.
    View in: PubMed
  59. Kissin I, Lee SS, Arthur GR, Bradley EL. Time course characteristics of acute tolerance development to continuously infused alfentanil in rats. Anesth Analg. 1996 Sep; 83(3):600-5. PMID: 8780289.
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  60. Tverskoy M, Oren M, Vaskovich M, Dashkovsky I, Kissin I. Ketamine enhances local anesthetic and analgesic effects of bupivacaine by peripheral mechanism: a study in postoperative patients. Neurosci Lett. 1996 Aug 30; 215(1):5-8. PMID: 8880740.
    View in: PubMed
  61. Tverskoy M, Oren M, Dashkovsky I, Kissin I. Alfentanil dose-response relationships for relief of postoperative pain. Anesth Analg. 1996 Aug; 83(2):387-93. PMID: 8694324.
    View in: PubMed
  62. Tverskoy M, Shagal M, Finger J, Kissin I. Spinal anesthesia and midazolam hypnotic requirements. Anesth Analg. 1996 Jul; 83(1):198-9. PMID: 8659749.
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  63. Tverskoy M, Shifrin V, Finger J, Fleyshman G, Kissin I. Effect of epidural bupivacaine block on midazolam hypnotic requirements. Reg Anesth. 1996 May-Jun; 21(3):209-13. PMID: 8744662.
    View in: PubMed
  64. Kissin I. Preemptive analgesia. Why its effect is not always obvious. Anesthesiology. 1996 May; 84(5):1015-9. PMID: 8623993.
    View in: PubMed
  65. Kissin I, Tverskoy M. Another explanation for reduced meperidine consumption in the immediate postoperative period. Anesth Analg. 1995 Jan; 80(1):214. PMID: 7802295.
    View in: PubMed
  66. Tverskoy M, Shagal M, Finger J, Kissin I. Subarachnoid bupivacaine blockade decreases midazolam and thiopental hypnotic requirements. J Clin Anesth. 1994 Nov-Dec; 6(6):487-90. PMID: 7880512.
    View in: PubMed
  67. Kissin I. Preemptive analgesia: terminology and clinical relevance. Anesth Analg. 1994 Oct; 79(4):809-10. PMID: 7943800.
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  68. Tverskoy M, Oz Y, Isakson A, Finger J, Bradley EL, Kissin I. Preemptive effect of fentanyl and ketamine on postoperative pain and wound hyperalgesia. Anesth Analg. 1994 Feb; 78(2):205-9. PMID: 8311269.
    View in: PubMed
  69. Vinik HR, Bradley EL, Kissin I. Triple anesthetic combination: propofol-midazolam-alfentanil. Anesth Analg. 1994 Feb; 78(2):354-8. PMID: 8311290.
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  70. Mehta D, Bradley EL, Kissin I. Metoclopramide decreases thiopental hypnotic requirements. Anesth Analg. 1993 Oct; 77(4):784-7. PMID: 8214666.
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  71. DeLorey TM, Kissin I, Brown P, Brown GB. Barbiturate-benzodiazepine interactions at the gamma-aminobutyric acidA receptor in rat cerebral cortical synaptoneurosomes. Anesth Analg. 1993 Sep; 77(3):598-605. PMID: 8396370.
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  72. Kissin I, Stanski DR, Brown PT, Bradley EL. Pentobarbital-morphine anesthetic interactions in terms of intensity of noxious stimulation required for arousal. Anesthesiology. 1993 Apr; 78(4):744-9. PMID: 8466074.
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  73. Kissin I. General anesthetic action: an obsolete notion? Anesth Analg. 1993 Feb; 76(2):215-8. PMID: 8424493.
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  74. Jebeles JA, Reilly JS, Gutierrez JF, Bradley EL, Kissin I. Tonsillectomy and adenoidectomy pain reduction by local bupivacaine infiltration in children. Int J Pediatr Otorhinolaryngol. 1993 Jan; 25(1-3):149-54. PMID: 8436459.
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  75. Kissin I, Brown PT, Bradley EL. Does midazolam inhibit the development of acute tolerance to the analgesic effect of alfentanil? Life Sci. 1993; 52(8):PL55-60. PMID: 8445997.
    View in: PubMed
  76. Kissin I, Brown PT, Bradley EL. Locomotor activity after recovery from hypnosis: midazolam-morphine versus midazolam. Anesth Analg. 1992 Dec; 75(6):929-31. PMID: 1443712.
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  77. Roytblat L, Katz J, Rozentsveig V, Gesztes T, Bradley EL, Kissin I. Anaesthetic interaction between thiopentone and ketamine. Eur J Anaesthesiol. 1992 Jul; 9(4):307-12. PMID: 1628634.
    View in: PubMed
  78. Jebeles JA, Reilly JS, Gutierrez JF, Bradley EL, Kissin I. The effect of pre-incisional infiltration of tonsils with bupivacaine on the pain following tonsillectomy under general anesthesia. Pain. 1991 Dec; 47(3):305-8. PMID: 1784501.
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  79. Kissin I, Brown PT, Bradley EL. Magnitude of acute tolerance to opioids is not related to their potency. Anesthesiology. 1991 Nov; 75(5):813-6. PMID: 1659255.
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  80. Kissin I, Brown PT, Robinson CA, Bradley EL. Acute tolerance to the hypnotic effect of morphine in rats. Anesth Analg. 1991 Nov; 73(5):619-21. PMID: 1952144.
    View in: PubMed
  81. Kissin I, Vinik HR, Bradley EL. Midazolam potentiates thiopental sodium anesthetic induction in patients. J Clin Anesth. 1991 Sep-Oct; 3(5):367-70. PMID: 1931060.
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  82. Kissin I, Brown PT, Johannson ML. Map of contributions to Anesthesiology and Anesthesia and Analgesia. Anesth Analg. 1991 Aug; 73(2):233-5. PMID: 1854041.
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  83. Mehta D, Bradley EL, Kissin I. Effect of alfentanil on hypnotic and antinociceptive components of thiopental sodium anesthesia. J Clin Anesth. 1991 Jul-Aug; 3(4):280-4. PMID: 1910794.
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  84. Vinik HR, Kissin I. Sedation in the ICU. Intensive Care Med. 1991; 17 Suppl 1:S20-3. PMID: 1774408.
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  85. Kissin I, Brown PT, Robinson CA, Bradley EL. Acute tolerance in morphine analgesia: continuous infusion and single injection in rats. Anesthesiology. 1991 Jan; 74(1):166-71. PMID: 1986642.
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  86. Crisologo PA, Neal B, Brown R, McDanal J, Kissin I. Lidocaine-induced spinal block can relieve central poststroke pain: role of the block in chronic pain diagnosis. Anesthesiology. 1991 Jan; 74(1):184-5. PMID: 1986644.
    View in: PubMed
  87. Kissin I, Brown PT, Bradley EL. Morphine and fentanyl anesthetic interactions with diazepam: relative antagonism in rats. Anesth Analg. 1990 Sep; 71(3):236-41. PMID: 2168134.
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  88. Kissin I, Brown PT, Bradley EL. Sedative and hypnotic midazolam-morphine interactions in rats. Anesth Analg. 1990 Aug; 71(2):137-43. PMID: 2375515.
    View in: PubMed
  89. Kissin I, Vinik HR, Castillo R, Bradley EL. Alfentanil potentiates midazolam-induced unconsciousness in subanalgesic doses. Anesth Analg. 1990 Jul; 71(1):65-9. PMID: 2363531.
    View in: PubMed
  90. Xavier AV, Farrell CE, McDanal J, Kissin I. Does antidromic activation of nociceptors play a role in sciatic radicular pain? Pain. 1990 Jan; 40(1):77-9. PMID: 2339019.
    View in: PubMed
  91. Tverskoy M, Cozacov C, Ayache M, Bradley EL, Kissin I. Postoperative pain after inguinal herniorrhaphy with different types of anesthesia. Anesth Analg. 1990 Jan; 70(1):29-35. PMID: 2297102.
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  92. Kissin I, Xavier AV, McDanal J. Blockade of sciatic nerve branches relieves sciatic radicular pain. Anesth Analg. 1989 Aug; 69(2):262-3. PMID: 2548416.
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  93. Kissin I, McDanal J, Xavier AV. Topical lidocaine for relief of superficial pain in postherpetic neuralgia. Neurology. 1989 Aug; 39(8):1132-3. PMID: 2761713.
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  94. Vinik HR, Bradley EL, Kissin I. Midazolam-alfentanil synergism for anesthetic induction in patients. Anesth Analg. 1989 Aug; 69(2):213-7. PMID: 2504079.
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  95. Kissin I, Gelman S. Isoflurane: myocardial ischemia without coronary steal? Anesth Analg. 1989 Jun; 68(6):825-6. PMID: 2735553.
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  96. Kissin I, Brown PT, Bradley EL, Robinson CA, Cassady JL. Diazepam--morphine hypnotic synergism in rats. Anesthesiology. 1989 Apr; 70(4):689-94. PMID: 2930007.
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  97. Xavier AV, McDanal J, Kissin I. Mechanism of pain caused by the nerve-root tension test in patients with sciatica. Neurology. 1989 Apr; 39(4):601-2. PMID: 2927688.
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  98. Tverskoy M, Fleyshman G, Ezry J, Bradley EL, Kissin I. Midazolam-morphine sedative interaction in patients. Anesth Analg. 1989 Mar; 68(3):282-5. PMID: 2919767.
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  99. Xavier AV, McDanal J, Kissin I. Relief of sciatic radicular pain by sciatic nerve block. Anesth Analg. 1988 Dec; 67(12):1177-80. PMID: 3269220.
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  100. Kissin I, Gelman S. Components of anaesthesia. Br J Anaesth. 1988 Aug; 61(2):237-8. PMID: 3415899.
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  101. Kissin I, Wright AJ. The introduction of hedonal: a Russian contribution to intravenous anesthesia. Anesthesiology. 1988 Aug; 69(2):242-5. PMID: 3044190.
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  102. Tverskoy M, Fleyshman G, Bradley EL, Kissin I. Midazolam-thiopental anesthetic interaction in patients. Anesth Analg. 1988 Apr; 67(4):342-5. PMID: 2833135.
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  103. Kissin I, McDanal J, Brown PT, Xavier AV, Bradley EL. Sympathetic blockade increases tactile sensitivity. Anesth Analg. 1987 Dec; 66(12):1251-5. PMID: 3688497.
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  104. Daghero AM, Bradley EL, Kissin I. Midazolam antagonizes the analgesic effect of morphine in rats. Anesth Analg. 1987 Oct; 66(10):944-7. PMID: 2820271.
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  105. Kissin I, Mason JO, Bradley EL. Morphine and fentanyl hypnotic interactions with thiopental. Anesthesiology. 1987 Sep; 67(3):331-5. PMID: 3631607.
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  106. Kissin I, Mason JO, Bradley EL. Pentobarbital and thiopental anesthetic interactions with midazolam. Anesthesiology. 1987 Jul; 67(1):26-31. PMID: 3605731.
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  107. Kissin I, Mason JO, Vinik HR, McDanal J, Bradley EL. Barbiturates inhibit stress-induced analgesia. Can J Anaesth. 1987 Mar; 34(2):146-51. PMID: 3829300.
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  108. Kissin I, Gelman S. Three components of anesthesia: one more reason to accept the concept. Anesth Analg. 1987 Jan; 66(1):98. PMID: 3800024.
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  109. Kissin I, Mason JO, Bradley EL. Morphine and fentanyl interactions with thiopental in relation to movement response to noxious stimulation. Anesth Analg. 1986 Nov; 65(11):1149-54. PMID: 3767013.
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  110. Jebeles JA, Kissin I, Bradley EL. Spinal and supraspinal mechanisms for morphine-pentobarbital antinociceptive interaction in relation to cardiac acceleration response in rats. Anesth Analg. 1986 Jun; 65(6):601-4. PMID: 3754702.
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  111. Castillo R, Kissin I, Bradley EL. Selective kappa opioid agonist for spinal analgesia without the risk of respiratory depression. Anesth Analg. 1986 Apr; 65(4):350-4. PMID: 3006552.
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  112. Kissin I. Morphine-halothane interaction controversy. Anesth Analg. 1986 Mar; 65(3):319-21. PMID: 3954106.
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  113. Person DL, Kissin I, Brown PT, Xavier AV, Vinik HR, Bradley EL. Morphine--caffeine analgesic interaction in rats. Anesth Analg. 1985 Sep; 64(9):851-6. PMID: 4025851.
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  114. Kissin I, Brown PT. Reserpine-induced changes in anesthetic action of fentanyl. Anesthesiology. 1985 May; 62(5):597-600. PMID: 3994025.
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  115. Menkhaus PG, Reves JG, Kissin I, Alvis JM, Govier AV, Samuelson PN, Lell WA, Henling CE, Bradley E. Cardiovascular effects of esmolol in anesthetized humans. Anesth Analg. 1985 Mar; 64(3):327-34. PMID: 2858169.
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  116. Ritchie G, Ebert JP, Jannett TC, Kissin I, Sheppard LC. A microcomputer based controller for neuromuscular block during surgery. Ann Biomed Eng. 1985; 13(1):3-15. PMID: 4003871.
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  117. Kissin I, Jebeles JA. Halothane antagonizes effect of morphine on the motor reaction threshold in rats. Anesthesiology. 1984 Dec; 61(6):671-6. PMID: 6507925.
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  118. Kissin I, Green D. Effect of halothane on cardiac acceleration response to somatic nerve stimulation in dogs. Anesthesiology. 1984 Dec; 61(6):708-11. PMID: 6507926.
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  119. Kissin I, Jebeles JA. Pentobarbital antagonizes the effect of morphine on cardiac acceleration response to noxious stimulation. Anesth Analg. 1984 Jul; 63(7):669-72. PMID: 6731894.
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  120. Kissin I, Kerr CR, Smith LR. Morphine-halothane interaction in rats. Anesthesiology. 1984 Jun; 60(6):553-61. PMID: 6731910.
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  121. Reves JG, Kissin I, Fournier S. Negative inotropic effects of midazolam. Anesthesiology. 1984 May; 60(5):517-8. PMID: 6711872.
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  122. Kissin I, Kerr CR, Smith LR. Effect of morphine on the heart rate response to noxious stimulation: interaction with halothane and naloxone. Pain. 1984 Apr; 18(4):351-8. PMID: 6328399.
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  123. Reves JG, Kissin I, Fournier SE, Smith LR. Additive negative inotropic effect of a combination of diazepam and fentanyl. Anesth Analg. 1984 Feb; 63(2):97-100. PMID: 6691589.
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  124. Kissin I, Reves JG. Halothane and ischemic injury. Anesthesiology. 1984 Jan; 60(1):74. PMID: 6691599.
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  125. Motomura S, Kissin I, Aultman DF, Reves JG. Effects of fentanyl and nitrous oxide on contractility of blood-perfused papillary muscle of the dog. Anesth Analg. 1984 Jan; 63(1):47-50. PMID: 6691564.
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  126. Kissin I, Motomura S, Aultman DF, Reves JG. Inotropic and anesthetic potencies of etomidate and thiopental in dogs. Anesth Analg. 1983 Nov; 62(11):961-5. PMID: 6625216.
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  127. Kissin I, Kerr CR, Smith LR. Assessment of anaesthetic action of morphine and fentanyl in rats. Can Anaesth Soc J. 1983 Nov; 30(6):623-8. PMID: 6640399.
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  128. Kissin I, Aultman DF, Smith LR. Effects of volatile anesthetics on myocardial oxidation-reduction status assessed by NADH fluorometry. Anesthesiology. 1983 Nov; 59(5):447-52. PMID: 6638554.
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  129. Tosone SR, Reves JG, Kissin I, Smith LR, Fournier SE. Hemodynamic responses to nifedipine in dogs anesthetized with halothane. Anesth Analg. 1983 Oct; 62(10):903-8. PMID: 6614523.
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  130. Marshall AG, Kissin I, Reves JG, Bradley EL, Blackstone EH. Interaction between negative inotropic effects of halothane and nifedipine in the isolated rat heart. J Cardiovasc Pharmacol. 1983 Jul-Aug; 5(4):592-7. PMID: 6193356.
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  131. Kissin I, Morgan PL, Smith LR. Comparison of isoflurane and halothane safety margins in rats. Anesthesiology. 1983 Jun; 58(6):556-61. PMID: 6859586.
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  132. Kissin I, Thomson CT, Smith LR. Effect of halothane on contractile function of ischemic myocardium. J Cardiovasc Pharmacol. 1983 May-Jun; 5(3):438-42. PMID: 6191143.
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  133. Kissin I, Morgan PL. Heart rate response to nociceptive stimulation as an index of anesthetic potency for enflurane. Anesthesiology. 1983 Jan; 58(1):109-10. PMID: 6848013.
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  134. Kissin I, Morgan PL, Smith LR. Anesthetic potencies of isoflurane, halothane, and diethyl ether for various end points of anesthesia. Anesthesiology. 1983 Jan; 58(1):88-92. PMID: 6848020.
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  135. Reves JG, Kissin I, Lell WA, Tosone S. Calcium entry blockers: uses and implications for anesthesiologists. Anesthesiology. 1982 Dec; 57(6):504-18. PMID: 6756213.
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  136. Kissin I, McGee T. Hypnotic effect of thiopental-lidocaine combination in the rat. Anesthesiology. 1982 Oct; 57(4):311-3. PMID: 7125268.
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  137. Kissin I, Kilpatrick JV. Effects of nifedipine on myocardial energy balance in experimental coronary vasoconstriction and occlusion. J Cardiovasc Pharmacol. 1982 Jan-Feb; 4(1):111-5. PMID: 6176785.
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  138. Kissin I, McGee T, Smith LR. The indices of potency for intravenous anaesthetics. Can Anaesth Soc J. 1981 Nov; 28(6):585-90. PMID: 7306864.
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  139. Kissin I, Cavender JB. Effect of propranolol on energy demand -- supply balance in myocardial ischemia. J Cardiovasc Pharmacol. 1981 Sep-Oct; 3(5):992-1001. PMID: 6168867.
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  140. Reves JG, Kissin I, Smith LR. The effective dose of midazolam. Anesthesiology. 1981 Jul; 55(1):82. PMID: 7247063.
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  141. Kissin I, Stanbridge R, Bishop SP, Reves JG. Effect of halothane on myocardial infarct size in rats. Can Anaesth Soc J. 1981 May; 28(3):239-43. PMID: 7237217.
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  142. Kissin I. Bioassay, potency, and intravenous anesthetics. Anesthesiology. 1980 Oct; 53(4):351-3. PMID: 7425367.
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  143. Kissin I. Diazepam anesthesia and myocardial contractility. Anesthesiology. 1980 Jul; 53(1):78. PMID: 7386915.
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  144. Kissin I, Reves JG, Mardis M. Is the rate-pressure product a misleading guide? Anesthesiology. 1980 Apr; 52(4):373-4. PMID: 7362064.
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