Contact, publication, and social network information about Harvard faculty and fellows. Harvard Catalyst Profiles
Keywords
Last Name
Institution

profileHemant S. Thatte, Ph.D.

TitleAssociate Professor of Surgery
InstitutionVeterans Affairs Boston Healthcare System
DepartmentSurgery
AddressVA Boston Healthcare System
Department of Surgery (MC112)
1400 VFW Pkwy
West Roxbury MA 02132
Phone857/203-5919
Fax857/203-5592
vCardDownload vCard (login for email)
Profile Picture

Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
I01BX000817     (THATTE, HEMANT SADASHIV)Oct 1, 2010 - Sep 30, 2014
VA
Functional Evaluation of Somah Technology for Heart Transplant
Role: Principal Investigator

F33HL009403     (THATTE, HEMANT)Mar 28, 1996
NIH/NHLBI
OXYSTEROLS AND SICKLE CELL DISEASE
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Meng H, Kou J, Ma R, Ding W, Kou Y, Cao M, Dong Z, Bi Y, Thatte HS, Shi J. Prognostic implications and procoagulant activity of phosphatidylserine exposure of blood cells and microparticles in patients with atrial fibrillation treated with pulmonary vein isolation. Mol Med Rep. 2017 Oct 11. PMID: 29039531.
    View in: PubMed
  2. Ma R, Xie R, Yu C, Si Y, Wu X, Zhao L, Yao Z, Fang S, Chen H, Novakovic V, Gao C, Kou J, Bi Y, Thatte HS, Yu B, Yang S, Zhou J, Shi J. Phosphatidylserine-mediated platelet clearance by endothelium decreases platelet aggregates and procoagulant activity in sepsis. Sci Rep. 2017 Jul 10; 7(1):4978. PMID: 28694452.
    View in: PubMed
  3. Yao Z, Wang L, Wu X, Zhao L, Chi C, Guo L, Tong D, Yang X, Dong Z, Deng R, Novakovic VA, Thatte HS, Bi Y, Tian Y, Shi J, Zhou J, Kou J, Hu S. Enhanced Procoagulant Activity on Blood Cells after Acute Ischemic Stroke. Transl Stroke Res. 2017 Feb; 8(1):83-91. PMID: 27650774.
    View in: PubMed
  4. Zhang Y, Meng H, Ma R, He Z, Wu X, Cao M, Yao Z, Zhao L, Li T, Deng R, Dong Z, Tian Y, Bi Y, Kou J, Thatte HS, Zhou J, Shi J. CIRCULATING MICROPARTICLES, BLOOD CELLS, AND ENDOTHELIUM INDUCE PROCOAGULANT ACTIVITY IN SEPSIS THROUGH PHOSPHATIDYLSERINE EXPOSURE. Shock. 2016 Mar; 45(3):299-307. PMID: 26513704.
    View in: PubMed
  5. He Z, Si Y, Jiang T, Ma R, Zhang Y, Cao M, Li T, Yao Z, Zhao L, Fang S, Yu B, Dong Z, Thatte HS, Bi Y, Kou J, Yang S, Piao D, Hao L, Zhou J, Shi J. Phosphotidylserine exposure and neutrophil extracellular traps enhance procoagulant activity in patients with inflammatory bowel disease. Thromb Haemost. 2016 Apr; 115(4):738-51. PMID: 26660948.
    View in: PubMed
  6. Ding W, Kou J, Meng H, Kou Y, He Z, Cao M, Wang L, Bi Y, Thatte HS, Shi J. Procoagulant activity induced by transcatheter closure of atrial septal defects is associated with exposure of phosphatidylserine on microparticles, platelets and red blood cells. Thromb Res. 2015 Aug; 136(2):354-60. PMID: 26099643.
    View in: PubMed
  7. Lowalekar SK, Treanor PR, Thatte HS. Cardioplegia at subnormothermia facilitates rapid functional resuscitation of hearts preserved in SOMAH for transplants. J Cardiothorac Surg. 2014 Sep 20; 9:155. PMID: 25238790; PMCID: PMC4182865.
  8. Lowalekar SK, Cao H, Lu XG, Treanor PR, Thatte HS. Subnormothermic preservation in somah: a novel approach for enhanced functional resuscitation of donor hearts for transplant. Am J Transplant. 2014 Oct; 14(10):2253-62. PMID: 25154901.
    View in: PubMed
  9. Lowalekar SK, Cao H, Lu XG, Treanor PR, Thatte HS. Sub-normothermic preservation of donor hearts for transplantation using a novel solution, Somah: a comparative pre-clinical study. J Heart Lung Transplant. 2014 Sep; 33(9):963-70. PMID: 25001113.
    View in: PubMed
  10. Lowalekar SK, Lu XG, Thatte HS. Further evaluation of Somah: long-term preservation, temperature effect, and prevention of ischemia-reperfusion injury in rat hearts harvested after cardiocirculatory death. Transplant Proc. 2013 Nov; 45(9):3192-7. PMID: 24182783.
    View in: PubMed
  11. Ng KK, Thatte HS, Spector M. Chondrogenic differentiation of adult mesenchymal stem cells and embryonic cells in collagen scaffolds. J Biomed Mater Res A. 2011 Nov; 99(2):275-82. PMID: 21858916.
    View in: PubMed
  12. Hussaini BE, Lu XG, Wolfe JA, Thatte HS. Evaluation of endoscopic vein extraction on structural and functional viability of saphenous vein endothelium. J Cardiothorac Surg. 2011 Jun 10; 6:82. PMID: 21663646; PMCID: PMC3125322.
  13. Ikuta T, Thatte HS, Tang JX, Mukerji I, Knee K, Bridges KR, Wang S, Montero-Huerta P, Joshi RM, Head CA. Nitric oxide reduces sickle hemoglobin polymerization: potential role of nitric oxide-induced charge alteration in depolymerization. Arch Biochem Biophys. 2011 Jun 01; 510(1):53-61. PMID: 21457702; PMCID: PMC3889650.
  14. Hussaini BE, Thatte HS, Rhodes BA, Treanor PR, Birjiniuk V. Thromboresistant surfaces with low-dose anticoagulation alleviate clopidogrel-related complications in patients undergoing coronary artery bypass grafting. J Thorac Cardiovasc Surg. 2011 Mar; 141(3):782-8. PMID: 21146837.
    View in: PubMed
  15. Hussaini BE, Treanor PR, Healey NA, Lu XG, Khuri SF, Thatte HS. Multifactorial comparison of modified and conventional perfusion strategies in a porcine model of cardiopulmonary bypass. J Surg Res. 2011 Jun 01; 168(1):e7-15. PMID: 20421111.
    View in: PubMed
  16. Hussaini BE, Treanor PR, Healey NA, Tilahun D, Srey R, Lu XG, Khuri SF, Thatte HS. Evaluation of blood components exposed to coated arterial filters in extracorporeal circuits. Perfusion. 2009 Sep; 24(5):317-23. PMID: 19965951.
    View in: PubMed
  17. Thatte HS, Rousou L, Hussaini BE, Lu XG, Treanor PR, Khuri SF. Development and evaluation of a novel solution, Somah, for the procurement and preservation of beating and nonbeating donor hearts for transplantation. Circulation. 2009 Oct 27; 120(17):1704-13. PMID: 19822811.
    View in: PubMed
  18. Kumbhani DJ, Healey NA, Thatte HS, Birjiniuk V, Crittenden MD, Treanor PR, Khuri SF. Intraoperative myocardial acidosis as a risk for hospital readmission after cardiac surgery. Am J Surg. 2009 Sep; 198(3):373-80. PMID: 19716885.
    View in: PubMed
  19. Thatte HS, He XD, Goyal RK. Imaging of nitric oxide in nitrergic neuromuscular neurotransmission in the gut. PLoS One. 2009; 4(4):e4990. PMID: 19340298; PMCID: PMC2659787.
  20. Rousou LJ, Taylor KB, Lu XG, Healey N, Crittenden MD, Khuri SF, Thatte HS. Saphenous vein conduits harvested by endoscopic technique exhibit structural and functional damage. Ann Thorac Surg. 2009 Jan; 87(1):62-70. PMID: 19101270.
    View in: PubMed
  21. Rousou LJ, Crittenden MD, Taylor KB, Healey NA, Gibson S, Thatte HS, Haime M, Khuri SF. Troponin I after cardiac surgery and its implications on myocardial protection, outcomes, and cost. Am J Surg. 2008 Nov; 196(5):703-9. PMID: 18789416.
    View in: PubMed
  22. Kabatas S, Yu D, He XD, Thatte HS, Benedict D, Hepgul KT, Black PM, Sabharwal S, Teng YD. Neural and anatomical abnormalities of the gastrointestinal system resulting from contusion spinal cord injury. Neuroscience. 2008 Jul 17; 154(4):1627-38. PMID: 18556138.
    View in: PubMed
  23. Rao VS, Titushkin IA, Moros EG, Pickard WF, Thatte HS, Cho MR. Nonthermal effects of radiofrequency-field exposure on calcium dynamics in stem cell-derived neuronal cells: elucidation of calcium pathways. Radiat Res. 2008 Mar; 169(3):319-29. PMID: 18302487.
    View in: PubMed
  24. Kumbhani DJ, Healey NA, Thatte HS, Nawas S, Crittenden MD, Birjiniuk V, Treanor PR, Khuri SF. Patients with diabetes mellitus undergoing cardiac surgery are at greater risk for developing intraoperative myocardial acidosis. J Thorac Cardiovasc Surg. 2007 Jun; 133(6):1566-72. PMID: 17532958.
    View in: PubMed
  25. Ramesh V, Thatte HS, McCarley RW, Basheer R. Adenosine and sleep deprivation promote NF-kappaB nuclear translocation in cholinergic basal forebrain. J Neurochem. 2007 Mar; 100(5):1351-63. PMID: 17316404.
    View in: PubMed
  26. Zhu DM, Dustin ML, Cairo CW, Thatte HS, Golan DE. Mechanisms of Cellular Avidity Regulation in CD2-CD58-Mediated T Cell Adhesion. ACS Chem Biol. 2006 Nov 21; 1(10):649-58. PMID: 17168569.
    View in: PubMed
  27. Dygert JH, Thatte HS, Kumbhani DJ, Najjar SF, Treanor PR, Khuri SF. Intracoronary shunt-induced endothelial cell damage in porcine heart. J Surg Res. 2006 Apr; 131(2):168-74. PMID: 16412472.
    View in: PubMed
  28. Thirunavukkarasu M, Penumathsa S, Juhasz B, Zhan L, Bagchi M, Yasmin T, Shara MA, Thatte HS, Bagchi D, Maulik N. Enhanced cardiovascular function and energy level by a novel chromium (III)-supplement. Biofactors. 2006; 27(1-4):53-67. PMID: 17012764.
    View in: PubMed
  29. Prabhala RH, Neri P, Bae JE, Tassone P, Shammas MA, Allam CK, Daley JF, Chauhan D, Blanchard E, Thatte HS, Anderson KC, Munshi NC. Dysfunctional T regulatory cells in multiple myeloma. Blood. 2006 Jan 01; 107(1):301-4. PMID: 16150935; PMCID: PMC1895365.
  30. Fischer TH, Thatte HS, Nichols TC, Bender-Neal DE, Bellinger AD, Vournakis JN. Synergistic platelet integrin signaling and factor XII activation in poly-N-acetyl glucosamine fiber-mediated hemostasis. Biomaterials. 2005 Sep; 26(27):5433-43. PMID: 15860200.
    View in: PubMed
  31. Gao W, Eisenhauer PB, Conn K, Lynch JA, Wells JM, Ullman MD, McKee A, Thatte HS, Fine RE. Insulin degrading enzyme is expressed in the human cerebrovascular endothelium and in cultured human cerebrovascular endothelial cells. Neurosci Lett. 2004 Nov 16; 371(1):6-11. PMID: 15500957.
    View in: PubMed
  32. Thatte HS, Zagarins SE, Amiji M, Khuri SF. Poly-N-acetyl glucosamine-mediated red blood cell interactions. J Trauma. 2004 Jul; 57(1 Suppl):S7-12. PMID: 15280744.
    View in: PubMed
  33. Najjar SF, Healey NA, Healey CM, McGarry T, Khan B, Thatte HS, Khuri SF. Evaluation of poly-N-acetyl glucosamine as a hemostatic agent in patients undergoing cardiac catheterization: a double-blind, randomized study. J Trauma. 2004 Jul; 57(1 Suppl):S38-41. PMID: 15280750.
    View in: PubMed
  34. Thatte HS, Zagarins S, Khuri SF, Fischer TH. Mechanisms of poly-N-acetyl glucosamine polymer-mediated hemostasis: platelet interactions. J Trauma. 2004 Jul; 57(1 Suppl):S13-21. PMID: 15280745.
    View in: PubMed
  35. Thatte HS, Rhee JH, Zagarins SE, Treanor PR, Birjiniuk V, Crittenden MD, Khuri SF. Acidosis-induced apoptosis in human and porcine heart. Ann Thorac Surg. 2004 Apr; 77(4):1376-83. PMID: 15063270.
    View in: PubMed
  36. Fischer TH, Connolly R, Thatte HS, Schwaitzberg SS. Comparison of structural and hemostatic properties of the poly-N-acetyl glucosamine Syvek Patch with products containing chitosan. Microsc Res Tech. 2004 Feb 15; 63(3):168-74. PMID: 14755604.
    View in: PubMed
  37. Thatte HS, Biswas KS, Najjar SF, Birjiniuk V, Crittenden MD, Michel T, Khuri SF. Multi-photon microscopic evaluation of saphenous vein endothelium and its preservation with a new solution, GALA. Ann Thorac Surg. 2003 Apr; 75(4):1145-52; discussion 1152. PMID: 12683553.
    View in: PubMed
  38. Basheer R, Arrigoni E, Thatte HS, Greene RW, Ambudkar IS, McCarley RW. Adenosine induces inositol 1,4,5-trisphosphate receptor-mediated mobilization of intracellular calcium stores in basal forebrain cholinergic neurons. J Neurosci. 2002 Sep 01; 22(17):7680-6. PMID: 12196591.
    View in: PubMed
  39. Cho MR, Marler JP, Thatte HS, Golan DE. Control of calcium entry in human fibroblasts by frequency-dependent electrical stimulation. Front Biosci. 2002 Jan 01; 7:a1-8. PMID: 11779692.
    View in: PubMed
  40. Thatte HS, Khuri SF. The coronary artery bypass conduit: I. Intraoperative endothelial injury and its implication on graft patency. Ann Thorac Surg. 2001 Dec; 72(6):S2245-52; discussion S2267-70. PMID: 11789848.
    View in: PubMed
  41. Sivarao DV, Mashimo HL, Thatte HS, Goyal RK. Lower esophageal sphincter is achalasic in nNOS(-/-) and hypotensive in W/W(v) mutant mice. Gastroenterology. 2001 Jul; 121(1):34-42. PMID: 11438492.
    View in: PubMed
  42. Biswas KS, Thatte HS, Najjar SF, Rhee JH, Birjiniuk V, Crittenden MD, Michel T, Khuri SF. Multi-photon microscopy in the evaluation of human saphenous vein. J Surg Res. 2001 Jan; 95(1):37-43. PMID: 11120633.
    View in: PubMed
  43. Cho MR, Thatte HS, Lee RC, Golan DE. Integrin-dependent human macrophage migration induced by oscillatory electrical stimulation. Ann Biomed Eng. 2000 Mar; 28(3):234-43. PMID: 10784088.
    View in: PubMed
  44. Akbarali HI, Thatte H, He XD, Giles WR, Goyal RK. Role of HERG-like K(+) currents in opossum esophageal circular smooth muscle. Am J Physiol. 1999 Dec; 277(6 Pt 1):C1284-90. PMID: 10600781.
    View in: PubMed
  45. Igarashi J, Thatte HS, Prabhakar P, Golan DE, Michel T. Calcium-independent activation of endothelial nitric oxide synthase by ceramide. Proc Natl Acad Sci U S A. 1999 Oct 26; 96(22):12583-8. PMID: 10535965; PMCID: PMC22998.
  46. Leiter LM, Thatte HS, Okafor C, Marks PW, Golan DE, Bridges KR. Chloramphenicol-induced mitochondrial dysfunction is associated with decreased transferrin receptor expression and ferritin synthesis in K562 cells and is unrelated to IRE-IRP interactions. J Cell Physiol. 1999 Sep; 180(3):334-44. PMID: 10430173.
    View in: PubMed
  47. Cho MR, Thatte HS, Silvia MT, Golan DE. Transmembrane calcium influx induced by ac electric fields. FASEB J. 1999 Apr; 13(6):677-83. PMID: 10094928.
    View in: PubMed
  48. Goetz RM, Thatte HS, Prabhakar P, Cho MR, Michel T, Golan DE. Estradiol induces the calcium-dependent translocation of endothelial nitric oxide synthase. Proc Natl Acad Sci U S A. 1999 Mar 16; 96(6):2788-93. PMID: 10077589; PMCID: PMC15847.
  49. Prabhakar P, Thatte HS, Goetz RM, Cho MR, Golan DE, Michel T. Receptor-regulated translocation of endothelial nitric-oxide synthase. J Biol Chem. 1998 Oct 16; 273(42):27383-8. PMID: 9765266.
    View in: PubMed
  50. Cho MR, Thatte HS, Lee RC, Golan DE. Reorganization of microfilament structure induced by ac electric fields. FASEB J. 1996 Nov; 10(13):1552-8. PMID: 8940302.
    View in: PubMed
  51. Golan DE, Corbett JD, Korsgren C, Thatte HS, Hayette S, Yawata Y, Cohen CM. Control of band 3 lateral and rotational mobility by band 4.2 in intact erythrocytes: release of band 3 oligomers from low-affinity binding sites. Biophys J. 1996 Mar; 70(3):1534-42. PMID: 8785311; PMCID: PMC1225081.
  52. Thatte HS, Bridges KR, Golan DE. ATP depletion causes translational immobilization of cell surface transferrin receptors in K562 cells. J Cell Physiol. 1996 Feb; 166(2):446-52. PMID: 8592005.
    View in: PubMed
  53. Thatte HS, Bridges KR, Golan DE. Microtubule inhibitors differentially affect translational movement, cell surface expression, and endocytosis of transferrin receptors in K562 cells. J Cell Physiol. 1994 Aug; 160(2):345-57. PMID: 7913709.
    View in: PubMed
  54. Cho MR, Thatte HS, Lee RC, Golan DE. Induced redistribution of cell surface receptors by alternating current electric fields. FASEB J. 1994 Jul; 8(10):771-6. PMID: 8050677.
    View in: PubMed
  55. Goncalves E, Yamada K, Thatte HS, Backer JM, Golan DE, Kahn CR, Shoelson SE. Optimizing transmembrane domain helicity accelerates insulin receptor internalization and lateral mobility. Proc Natl Acad Sci U S A. 1993 Jun 15; 90(12):5762-6. PMID: 8390680; PMCID: PMC46802.
  56. Thatte HS, Kasschau MR, Furlong ST, Byam-Smith MP, Williams DF, Golan DE. Schistosoma mansoni: membranes from adult worms reversibly perturb shape, volume, and membrane organization of intact human red blood cells. Exp Parasitol. 1993 Feb; 76(1):13-22. PMID: 8467896.
    View in: PubMed
  57. Thatte HS, Schrier SL. Comparison of transferrin receptor-mediated endocytosis and drug-induced endocytosis in human neonatal and adult RBCs. Blood. 1988 Nov; 72(5):1693-700. PMID: 3179445.
    View in: PubMed
  58. Thatte HS, Mickelson JR, Addis PB, Louis CF. Erythrocyte membrane ATPase and calcium pumping activities in porcine malignant hyperthermia. Biochem Med Metab Biol. 1987 Dec; 38(3):355-65. PMID: 2963654.
    View in: PubMed
  59. Thatte HS, Addis PB, Thomas DD, Bigelow DJ, Mickelson JR, Louis CF. Temperature-dependent abnormalities of the erythrocyte membrane in porcine malignant hyperthermia. Biochem Med Metab Biol. 1987 Dec; 38(3):366-77. PMID: 2829949.
    View in: PubMed
  60. Mickelson JR, Thatte HS, Beaudry TM, Gallant EM, Louis CF. Increased skeletal muscle acetylcholinesterase activity in porcine malignant hyperthermia. Muscle Nerve. 1987 Oct; 10(8):723-7. PMID: 3683445.
    View in: PubMed
  61. O'Brien PJ, Rooney MT, Reik TR, Thatte HS, Rempel WE, Addis PB, Louis CF. Porcine malignant hyperthermia susceptibility: erythrocytic osmotic fragility. Am J Vet Res. 1985 Jul; 46(7):1451-6. PMID: 4026025.
    View in: PubMed
  62. O'Brien PJ, Forsyth GW, Olexson DW, Thatte HS, Addis PB. Canine malignant hyperthermia susceptibility: erythrocytic defects--osmotic fragility, glucose-6-phosphate dehydrogenase deficiency and abnormal Ca2+ homeostasis. Can J Comp Med. 1984 Oct; 48(4):381-9. PMID: 6150753; PMCID: PMC1236089.
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact feedbackcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Thatte's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts Expand Description
_
Co-Authors Expand Description
_
Similar People Expand Description
_
Same Department Expand Description
Physical Neighbors Expand Description
_