Harvard Catalyst Profiles

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Astrid Weins, Ph.D., M.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R03DK107918 (WEINS, ASTRID) Aug 1, 2016 - May 31, 2018
    NIH/NIDDK
    Podocyte Cell Cycle Regulation after DNA Damage
    Role: Principal Investigator
  2. K08DK093783 (WEINS, ASTRID) Feb 15, 2012 - Nov 30, 2016
    NIH/NIDDK
    Senescence and Autophagy as Mediators of Glomerular Injury in Diabetes
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Sekulic M, Pichler Sekulic S, Weins A. Heavy and light chain (AHL)-type cardiac amyloidosis: first histopathologic-proven case illustrating involvement of the heart. Virchows Arch. 2020 May 09. PMID: 32388718.
    Citations:    
  2. Patel AB, Choi JY, Mutter WP, Weins A, Riella LV. Crystalline light chain proximal tubulopathy and podocytopathy: a case report. J Bras Nefrol. 2020 Mar; 42(1):99-105. PMID: 31799982.
    Citations:    
  3. Subramanian A, Sidhom EH, Emani M, Vernon K, Sahakian N, Zhou Y, Kost-Alimova M, Slyper M, Waldman J, Dionne D, Nguyen LT, Weins A, Marshall JL, Rosenblatt-Rosen O, Regev A, Greka A. Single cell census of human kidney organoids shows reproducibility and diminished off-target cells after transplantation. Nat Commun. 2019 11 29; 10(1):5462. PMID: 31784515.
    Citations:    
  4. Shao H, Wingert B, Weins A, Pollak MR, Camacho C, Wells A. Focal segmental glomerulosclerosis ACTN4 mutants binding to actin: regulation by phosphomimetic mutations. Sci Rep. 2019 10 29; 9(1):15517. PMID: 31664084.
    Citations:    
  5. Siedlecki AM, Benson C, Frates M, Azzi J, Hoffman RJ, Milford E, Weins A, Chandraker A, Mc Donald N, Philip White J, Abdi R. First Report of Perfluorobutane Microsphere-Enhanced Ultrasound in the Transplant Kidney. Transplantation. 2019 10; 103(10):e283-e284. PMID: 31335773.
    Citations:    
  6. Dvela-Levitt M, Kost-Alimova M, Emani M, Kohnert E, Thompson R, Sidhom EH, Rivadeneira A, Sahakian N, Roignot J, Papagregoriou G, Montesinos MS, Clark AR, McKinney D, Gutierrez J, Roth M, Ronco L, Elonga E, Carter TA, Gnirke A, Melanson M, Hartland K, Wieder N, Hsu JC, Deltas C, Hughey R, Bleyer AJ, Kmoch S, Živná M, Barešova V, Kota S, Schlondorff J, Heiman M, Alper SL, Wagner F, Weins A, Golub TR, Lander ES, Greka A. Small Molecule Targets TMED9 and Promotes Lysosomal Degradation to Reverse Proteinopathy. Cell. 2019 07 25; 178(3):521-535.e23. PMID: 31348885.
    Citations:    
  7. Sekulic M, Waikar S, Motwani SS, Weins A, Rennke HG. Chromogranin A Tubulopathy: Differing Histopathologic Patterns of Acute Tubular Injury in the Setting of Neuroendocrine Neoplasms. Kidney Int Rep. 2019 Aug; 4(8):1085-1093. PMID: 31440699.
    Citations:    
  8. Kelly YP, Weins A, Yeung MY. Accelerated Oxalosis Contributing to Delayed Graft Function after Renal Transplantation. Case Rep Transplant. 2019; 2019:8942062. PMID: 31019830.
    Citations:    
  9. Sekulic M, Martin S, Lal A, Weins A. Intravascular Large B-Cell Lymphoma of the Kidney. Kidney Int Rep. 2018 Nov; 3(6):1501-1505. PMID: 30450479.
    Citations:    
  10. Christov M, Clark AR, Corbin B, Hakroush S, Rhee EP, Saito H, Brooks D, Hesse E, Bouxsein M, Galjart N, Jung JY, Mundel P, Jüppner H, Weins A, Greka A. Inducible podocyte-specific deletion of CTCF drives progressive kidney disease and bone abnormalities. JCI Insight. 2018 02 22; 3(4). PMID: 29467330.
    Citations: 1     Fields:    
  11. Zhou Y, Castonguay P, Sidhom EH, Clark AR, Dvela-Levitt M, Kim S, Sieber J, Wieder N, Jung JY, Andreeva S, Reichardt J, Dubois F, Hoffmann SC, Basgen JM, Montesinos MS, Weins A, Johnson AC, Lander ES, Garrett MR, Hopkins CR, Greka A. A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models. Science. 2017 12 08; 358(6368):1332-1336. PMID: 29217578.
    Citations: 13     Fields:    Translation:AnimalsCells
  12. Zhao Y, Bucur O, Irshad H, Chen F, Weins A, Stancu AL, Oh EY, DiStasio M, Torous V, Glass B, Stillman IE, Schnitt SJ, Beck AH, Boyden ES. Nanoscale imaging of clinical specimens using pathology-optimized expansion microscopy. Nat Biotechnol. 2017 Aug; 35(8):757-764. PMID: 28714966.
    Citations: 9     Fields:    Translation:Humans
  13. Yoon KW, Byun S, Kwon E, Hwang SY, Chu K, Hiraki M, Jo SH, Weins A, Hakroush S, Cebulla A, Sykes DB, Greka A, Mundel P, Fisher DE, Mandinova A, Lee SW. Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53. Science. 2015 Jul 31; 349(6247):1261669. PMID: 26228159.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  14. Weins A, Wong JS, Basgen JM, Gupta R, Daehn I, Casagrande L, Lessman D, Schwartzman M, Meliambro K, Patrakka J, Shaw A, Tryggvason K, He JC, Nicholas SB, Mundel P, Campbell KN. Dendrin ablation prolongs life span by delaying kidney failure. Am J Pathol. 2015 Aug; 185(8):2143-57. PMID: 26073036.
    Citations: 8     Fields:    Translation:AnimalsCells
  15. Balbas MD, Burgess MR, Murali R, Wongvipat J, Skaggs BJ, Mundel P, Weins A, Sawyers CL. MAGI-2 scaffold protein is critical for kidney barrier function. Proc Natl Acad Sci U S A. 2014 Oct 14; 111(41):14876-81. PMID: 25271328.
    Citations: 8     Fields:    Translation:AnimalsCells
  16. Batal I, De Serres SA, Mfarrej BG, Grafals M, Pinkus GS, Kalra A, Weins A, Bijol V, Rennke HG, Guleria I, Abdi R, Chandraker A, Najafian N. Glomerular inflammation correlates with endothelial injury and with IL-6 and IL-1ß secretion in the peripheral blood. Transplantation. 2014 May 27; 97(10):1034-42. PMID: 24406453.
    Citations: 4     Fields:    Translation:HumansCells
  17. Barua M, Stellacci E, Stella L, Weins A, Genovese G, Muto V, Caputo V, Toka HR, Charoonratana VT, Tartaglia M, Pollak MR. Mutations in PAX2 associate with adult-onset FSGS. J Am Soc Nephrol. 2014 Sep; 25(9):1942-53. PMID: 24676634.
    Citations: 13     Fields:    Translation:HumansCells
  18. Greka A, Weins A, Mundel P. Abatacept in B7-1-positive proteinuric kidney disease. N Engl J Med. 2014 03 27; 370(13):1263-6. PMID: 24670178.
    Citations: 2     Fields:    Translation:Humans
  19. Hakroush S, Cebulla A, Schaldecker T, Behr D, Mundel P, Weins A. Extensive podocyte loss triggers a rapid parietal epithelial cell response. J Am Soc Nephrol. 2014 May; 25(5):927-38. PMID: 24335975.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  20. Schaldecker T, Kim S, Tarabanis C, Tian D, Hakroush S, Castonguay P, Ahn W, Wallentin H, Heid H, Hopkins CR, Lindsley CW, Riccio A, Buvall L, Weins A, Greka A. Inhibition of the TRPC5 ion channel protects the kidney filter. J Clin Invest. 2013 Dec; 123(12):5298-309. PMID: 24231357.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  21. Yu CC, Fornoni A, Weins A, Hakroush S, Maiguel D, Sageshima J, Chen L, Ciancio G, Faridi MH, Behr D, Campbell KN, Chang JM, Chen HC, Oh J, Faul C, Arnaout MA, Fiorina P, Gupta V, Greka A, Burke GW, Mundel P. Abatacept in B7-1-positive proteinuric kidney disease. N Engl J Med. 2013 Dec 19; 369(25):2416-23. PMID: 24206430.
    Citations: 111     Fields:    Translation:HumansCells
  22. Sieber J, Weins A, Kampe K, Gruber S, Lindenmeyer MT, Cohen CD, Orellana JM, Mundel P, Jehle AW. Susceptibility of podocytes to palmitic acid is regulated by stearoyl-CoA desaturases 1 and 2. Am J Pathol. 2013 Sep; 183(3):735-44. PMID: 23867797.
    Citations: 12     Fields:    Translation:HumansCells
  23. Buvall L, Rashmi P, Lopez-Rivera E, Andreeva S, Weins A, Wallentin H, Greka A, Mundel P. Proteasomal degradation of Nck1 but not Nck2 regulates RhoA activation and actin dynamics. Nat Commun. 2013; 4:2863. PMID: 24287595.
    Citations: 12     Fields:    Translation:HumansCells
  24. Al-Romaih KI, Genovese G, Al-Mojalli H, Al-Othman S, Al-Manea H, Al-Suleiman M, Al-Jondubi M, Atallah N, Al-Rodayyan M, Weins A, Pollak MR, Adra CN. Genetic diagnosis in consanguineous families with kidney disease by homozygosity mapping coupled with whole-exome sequencing. Am J Kidney Dis. 2011 Aug; 58(2):186-95. PMID: 21658830.
    Citations: 8     Fields:    Translation:Humans
  25. Gu C, Yaddanapudi S, Weins A, Osborn T, Reiser J, Pollak M, Hartwig J, Sever S. Direct dynamin-actin interactions regulate the actin cytoskeleton. EMBO J. 2010 Nov 03; 29(21):3593-606. PMID: 20935625.
    Citations: 70     Fields:    Translation:HumansAnimalsCells
  26. Ward SM, Weins A, Pollak MR, Weitz DA. Dynamic viscoelasticity of actin cross-linked with wild-type and disease-causing mutant alpha-actinin-4. Biophys J. 2008 Nov 15; 95(10):4915-23. PMID: 18689451.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  27. Henderson JM, Al-Waheeb S, Weins A, Dandapani SV, Pollak MR. Mice with altered alpha-actinin-4 expression have distinct morphologic patterns of glomerular disease. Kidney Int. 2008 Mar; 73(6):741-50. PMID: 18185509.
    Citations: 13     Fields:    Translation:HumansAnimals
  28. Lee SH, Weins A, Hayes DB, Pollak MR, Dominguez R. Crystal structure of the actin-binding domain of alpha-actinin-4 Lys255Glu mutant implicated in focal segmental glomerulosclerosis. J Mol Biol. 2008 Feb 15; 376(2):317-24. PMID: 18164029.
    Citations: 12     Fields:    Translation:HumansCells
  29. Weins A, Schlondorff JS, Nakamura F, Denker BM, Hartwig JH, Stossel TP, Pollak MR. Disease-associated mutant alpha-actinin-4 reveals a mechanism for regulating its F-actin-binding affinity. Proc Natl Acad Sci U S A. 2007 Oct 09; 104(41):16080-5. PMID: 17901210.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  30. Weins A, Kenlan P, Herbert S, Le TC, Villegas I, Kaplan BS, Appel GB, Pollak MR. Mutational and Biological Analysis of alpha-actinin-4 in focal segmental glomerulosclerosis. J Am Soc Nephrol. 2005 Dec; 16(12):3694-701. PMID: 16251236.
    Citations: 55     Fields:    Translation:Humans
  31. Weins A, Schwarz K, Faul C, Barisoni L, Linke WA, Mundel P. Differentiation- and stress-dependent nuclear cytoplasmic redistribution of myopodin, a novel actin-bundling protein. J Cell Biol. 2001 Oct 29; 155(3):393-404. PMID: 11673475.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.