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profileAstrid Weins, Ph.D., M.D.

TitleAssistant Professor of Pathology
InstitutionBrigham and Women's Hospital
DepartmentPathology
AddressBrigham and Womens Hospital
Pathology, Amory-3
75 Francis St
Boston MA 02115
Phone617/935-9102
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Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R03DK107918     (WEINS, ASTRID)Aug 1, 2016 - May 31, 2018
NIH/NIDDK
Podocyte Cell Cycle Regulation after DNA Damage
Role: Principal Investigator

K08DK093783     (WEINS, ASTRID)Feb 15, 2012 - Nov 30, 2016
NIH/NIDDK
Senescence and Autophagy as Mediators of Glomerular Injury in Diabetes
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Zhao Y, Bucur O, Irshad H, Chen F, Weins A, Stancu AL, Oh EY, DiStasio M, Torous V, Glass B, Stillman IE, Schnitt SJ, Beck AH, Boyden ES. Nanoscale imaging of clinical specimens using pathology-optimized expansion microscopy. Nat Biotechnol. 2017 Aug; 35(8):757-764. PMID: 28714966.
    View in: PubMed
  2. Yoon KW, Byun S, Kwon E, Hwang SY, Chu K, Hiraki M, Jo SH, Weins A, Hakroush S, Cebulla A, Sykes DB, Greka A, Mundel P, Fisher DE, Mandinova A, Lee SW. Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53. Science. 2015 Jul 31; 349(6247):1261669. PMID: 26228159.
    View in: PubMed
  3. Weins A, Wong JS, Basgen JM, Gupta R, Daehn I, Casagrande L, Lessman D, Schwartzman M, Meliambro K, Patrakka J, Shaw A, Tryggvason K, He JC, Nicholas SB, Mundel P, Campbell KN. Dendrin ablation prolongs life span by delaying kidney failure. Am J Pathol. 2015 Aug; 185(8):2143-57. PMID: 26073036; PMCID: PMC4530132.
  4. Balbas MD, Burgess MR, Murali R, Wongvipat J, Skaggs BJ, Mundel P, Weins A, Sawyers CL. MAGI-2 scaffold protein is critical for kidney barrier function. Proc Natl Acad Sci U S A. 2014 Oct 14; 111(41):14876-81. PMID: 25271328; PMCID: PMC4205655.
  5. Batal I, De Serres SA, Mfarrej BG, Grafals M, Pinkus GS, Kalra A, Weins A, Bijol V, Rennke HG, Guleria I, Abdi R, Chandraker A, Najafian N. Glomerular inflammation correlates with endothelial injury and with IL-6 and IL-1ß secretion in the peripheral blood. Transplantation. 2014 May 27; 97(10):1034-42. PMID: 24406453.
    View in: PubMed
  6. Barua M, Stellacci E, Stella L, Weins A, Genovese G, Muto V, Caputo V, Toka HR, Charoonratana VT, Tartaglia M, Pollak MR. Mutations in PAX2 associate with adult-onset FSGS. J Am Soc Nephrol. 2014 Sep; 25(9):1942-53. PMID: 24676634; PMCID: PMC4147972.
  7. Greka A, Weins A, Mundel P. Abatacept in B7-1-positive proteinuric kidney disease. N Engl J Med. 2014 Mar 27; 370(13):1263-6. PMID: 24670178.
    View in: PubMed
  8. Hakroush S, Cebulla A, Schaldecker T, Behr D, Mundel P, Weins A. Extensive podocyte loss triggers a rapid parietal epithelial cell response. J Am Soc Nephrol. 2014 May; 25(5):927-38. PMID: 24335975; PMCID: PMC4005306.
  9. Schaldecker T, Kim S, Tarabanis C, Tian D, Hakroush S, Castonguay P, Ahn W, Wallentin H, Heid H, Hopkins CR, Lindsley CW, Riccio A, Buvall L, Weins A, Greka A. Inhibition of the TRPC5 ion channel protects the kidney filter. J Clin Invest. 2013 Dec; 123(12):5298-309. PMID: 24231357; PMCID: PMC3859394.
  10. Yu CC, Fornoni A, Weins A, Hakroush S, Maiguel D, Sageshima J, Chen L, Ciancio G, Faridi MH, Behr D, Campbell KN, Chang JM, Chen HC, Oh J, Faul C, Arnaout MA, Fiorina P, Gupta V, Greka A, Burke GW, Mundel P. Abatacept in B7-1-positive proteinuric kidney disease. N Engl J Med. 2013 Dec 19; 369(25):2416-23. PMID: 24206430; PMCID: PMC3951406.
  11. Sieber J, Weins A, Kampe K, Gruber S, Lindenmeyer MT, Cohen CD, Orellana JM, Mundel P, Jehle AW. Susceptibility of podocytes to palmitic acid is regulated by stearoyl-CoA desaturases 1 and 2. Am J Pathol. 2013 Sep; 183(3):735-44. PMID: 23867797; PMCID: PMC3763774.
  12. Buvall L, Rashmi P, Lopez-Rivera E, Andreeva S, Weins A, Wallentin H, Greka A, Mundel P. Proteasomal degradation of Nck1 but not Nck2 regulates RhoA activation and actin dynamics. Nat Commun. 2013; 4:2863. PMID: 24287595; PMCID: PMC4698162.
  13. Al-Romaih KI, Genovese G, Al-Mojalli H, Al-Othman S, Al-Manea H, Al-Suleiman M, Al-Jondubi M, Atallah N, Al-Rodayyan M, Weins A, Pollak MR, Adra CN. Genetic diagnosis in consanguineous families with kidney disease by homozygosity mapping coupled with whole-exome sequencing. Am J Kidney Dis. 2011 Aug; 58(2):186-95. PMID: 21658830; PMCID: PMC3291334.
  14. Gu C, Yaddanapudi S, Weins A, Osborn T, Reiser J, Pollak M, Hartwig J, Sever S. Direct dynamin-actin interactions regulate the actin cytoskeleton. EMBO J. 2010 Nov 03; 29(21):3593-606. PMID: 20935625; PMCID: PMC2982766.
  15. Ward SM, Weins A, Pollak MR, Weitz DA. Dynamic viscoelasticity of actin cross-linked with wild-type and disease-causing mutant alpha-actinin-4. Biophys J. 2008 Nov 15; 95(10):4915-23. PMID: 18689451; PMCID: PMC2576355.
  16. Henderson JM, Al-Waheeb S, Weins A, Dandapani SV, Pollak MR. Mice with altered alpha-actinin-4 expression have distinct morphologic patterns of glomerular disease. Kidney Int. 2008 Mar; 73(6):741-50. PMID: 18185509; PMCID: PMC2980842.
  17. Lee SH, Weins A, Hayes DB, Pollak MR, Dominguez R. Crystal structure of the actin-binding domain of alpha-actinin-4 Lys255Glu mutant implicated in focal segmental glomerulosclerosis. J Mol Biol. 2008 Feb 15; 376(2):317-24. PMID: 18164029; PMCID: PMC2255586.
  18. Weins A, Schlondorff JS, Nakamura F, Denker BM, Hartwig JH, Stossel TP, Pollak MR. Disease-associated mutant alpha-actinin-4 reveals a mechanism for regulating its F-actin-binding affinity. Proc Natl Acad Sci U S A. 2007 Oct 09; 104(41):16080-5. PMID: 17901210; PMCID: PMC2042165.
  19. Weins A, Kenlan P, Herbert S, Le TC, Villegas I, Kaplan BS, Appel GB, Pollak MR. Mutational and Biological Analysis of alpha-actinin-4 in focal segmental glomerulosclerosis. J Am Soc Nephrol. 2005 Dec; 16(12):3694-701. PMID: 16251236.
    View in: PubMed
  20. Weins A, Schwarz K, Faul C, Barisoni L, Linke WA, Mundel P. Differentiation- and stress-dependent nuclear cytoplasmic redistribution of myopodin, a novel actin-bundling protein. J Cell Biol. 2001 Oct 29; 155(3):393-404. PMID: 11673475; PMCID: PMC2150840.
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