Harvard Catalyst Profiles

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Joseph T. Coyle, M.D.

Title
Institution
Department
Address
Phone
Fax

Biography
1968
Henry Strong Denison Research Scholarship
1969
Alpha Omega Alpha Student Research Award
1978
A.E.Bennett Award in Basic Science
1979
John Jacob Abel Award
1979
Sato International Memorial Award
1982
Daniel Efron Award
1985
Foundations' Fund Prize for Research in Psychiatry
1986
Alpha Omega Alpha Honor Society
1990
Institute of Medicine of the National Academy of Sciences
1990
Nancy and Daniel Weisman Award for Research on Mental Retardation
1991
Edward A. Strecker Award
1991
Gold Medal Award
1991 - 1992
President
1992
William R. McAlpin, Jr. Research Achievement Award
1994
Fellow
1997
Award for Neuropsychiatric Research
1997
Exemplary Psychiatrist Award
2001 - 2002
President
2001
2001 Highly Cited Researchers Award
2001 - 2004
Council
2001
Special Achievement Award
2004
Lieber Prize for Schizophrenia Research
2006
Fellow
2007
2007 Sanctae Crucis Award
2007
2008 Julius Axelrod Award

Overview
Joseph T. Coyle, M.D. holds the Eben S. Draper Chair of Psychiatry and Neuroscience at Harvard Medical School. From 1991 to 2001, he served as Chairman of the Consolidated Department of Psychiatry at Harvard Medical School, which included the nine hospital programs of psychiatry affiliated with the Medical School. After graduating from Holy Cross College, he received his medical degree (M.D.) from Johns Hopkins School of Medicine in 1969. Following an internship in Pediatrics, he spent three years at the National Institutes of Health as a research fellow in the laboratory of Nobel laureate Julius Axelrod, Ph.D. He returned to Hopkins in 1973 to complete his Psychiatric residency, in which he is board certified, and joined the faculty in 1975. In 1980, he was promoted to Professor of Neuroscience, Pharmacology and Psychiatry; and in 1982 he assumed the Directorship of the Division of Child and Adolescent Psychiatry, being named the Distinguished Service Professor in 1985.

Dr. Coyle's research interests include developmental neurobiology, mechanisms of neuronal vulnerability and psychopharmacology. In particular, he has carried out research on the role of glutamatergic neurons in the pathophysiology of neuropsychiatric disorders for 30 years. He has a long commitment to training. In the mid-1980s, he was the PI of a NIMH Training Grant that had a core curriculum, which introduced PhD fellows to psychiatric illnesses with patient demonstrations. While President of the Society of Neuroscience, he worked with NIMH to develop a minority Training Grant. For the last 10 years, he has served as co-PI on this grant, which was the foundation for minority mentoring and net-working for the Society. He has published over 500 scientific articles and has edited seven books. His research has been cited over 35,000 times, and his H-factor is 93. He has received continuous NIH funding for his research for 30 years and is the Director of an NIMH Conte Center on the Neurobiology of Schizophrenia (2001-11).

Dr. Coyle is a member of the Institute of Medicine of the National Academy of Sciences (1990), a fellow of the American Academy of Arts and Sciences (1993), a Distinguished Fellow of the American Psychiatric Association, a fellow of the American College of Psychiatry and fellow of the American Association for the Advancement of Science. He served on the National Advisory Mental Health Council for the National Institute of Mental Health (1990-94). He is Past-President of the American College of Neuropsychopharmacology (2001) and Past-President (1991) of the Society for Neuroscience, an organization with more than 35,000 members. He sits on over 20 journal editorial boards including JAMA and is the Editor-in-Chief of the Archives of General Psychiatry, the most highly cited journal in the field (citation impact:15.98).

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21DA035427 (COYLE, JOSEPH T.) May 15, 2013 - Jul 31, 2015
    NIH
    Drug Abuse, Schizophrenia, NMDA Receptor
    Role: Principal Investigator
  2. P50MH060450 (COYLE, JOSEPH T) Jul 21, 2000 - May 31, 2012
    NIH
    Glutamatergic Dysfunction and Schizophrenia
    Role: Principal Investigator
  3. R01MH051290 (COYLE, JOSEPH T.) Aug 1, 1994 - Apr 30, 2018
    NIH
    Psychosis and Brain Glutamate
    Role: Principal Investigator
  4. P01MH046529 (MORAN, TIMOTHY H.) Apr 1, 1990 - Mar 31, 1994
    NIH
    GENE DOSAGE EFFECTS ON THE DEVELOPING BRAIN
    Role: Co-Principal Investigator
  5. U09MH041623 (COYLE, JAMES T) Sep 30, 1985 - Oct 31, 1989
    NIH
    SCIENTIFIC EVALUATION AND PLANNING
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Halmi K, Coyle JT. Dona Lee Wong (1946-2022). Neuropsychopharmacology. 2023 Mar 01. PMID: 36859480.
    Citations:    Fields:    
  2. Liu D, Zinski A, Mishra A, Noh H, Park GH, Qin Y, Olorife O, Park JM, Abani CP, Park JS, Fung J, Sawaqed F, Coyle JT, Stahl E, Bendl J, Fullard JF, Roussos P, Zhang X, Stanton PK, Yin C, Huang W, Kim HY, Won H, Cho JH, Chung S. Impact of schizophrenia GWAS loci converge onto distinct pathways in cortical interneurons vs glutamatergic neurons during development. Mol Psychiatry. 2022 10; 27(10):4218-4233. PMID: 35701597.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  3. Nomoto M, Konopaske GT, Yamashita N, Aoki R, Jitsuki-Takahashi A, Nakamura H, Makihara H, Saito M, Saigusa Y, Nakamura F, Watanabe K, Baba T, Benes FM, Tobe BTD, Pernia CD, Coyle JT, Sidman RL, Hirayasu Y, Snyder EY, Goshima Y. Clinical evidence that a dysregulated master neural network modulator may aid in diagnosing schizophrenia. Proc Natl Acad Sci U S A. 2021 08 03; 118(31). PMID: 34330827.
    Citations: 1     Fields:    Translation:Humans
  4. Coyle JT, Öngür D. In Memoriam: James C. Harris, MD. JAMA Psychiatry. 2021 Jun 16. PMID: 34132763.
    Citations:    Fields:    
  5. Dallérac G, Li X, Lecouflet P, Morisot N, Sacchi S, Asselot R, Pham TH, Potier B, Watson DJG, Schmidt S, Levasseur G, Fossat P, Besedin A, Rivet JM, Coyle JT, Collo G, Pollegioni L, Kehr J, Galante M, Fone KC, Gardier AM, Freret T, Contarino A, Millan MJ, Mothet JP. Dopaminergic neuromodulation of prefrontal cortex activity requires the NMDA receptor coagonist d-serine. Proc Natl Acad Sci U S A. 2021 06 08; 118(23). PMID: 34083436.
    Citations: 6     Fields:    Translation:AnimalsCells
  6. Aguilar DD, Radzik LK, Schiffino FL, Folorunso OO, Zielinski MR, Coyle JT, Balu DT, McNally JM. Altered neural oscillations and behavior in a genetic mouse model of NMDA receptor hypofunction. Sci Rep. 2021 04 27; 11(1):9031. PMID: 33907230; PMCID: PMC8079688.
    Citations: 7     Fields:    Translation:Animals
  7. Coyle JT, Holtzheimer PE, Salzman C. In memoriam-Alan Ivan Green, MD (1943-2020). Neuropsychopharmacology. 2021 Apr; 46(5):1058-1059. PMID: 33558675.
    Citations:    Fields:    
  8. Coyle JT, Ruzicka WB, Balu DT. Fifty Years of Research on Schizophrenia: The Ascendance of the Glutamatergic Synapse. Am J Psychiatry. 2020 12 01; 177(12):1119-1128. PMID: 33256439; PMCID: PMC8011846.
    Citations: 8     Fields:    Translation:HumansCells
  9. Takagi S, Balu DT, Coyle JT. Factors regulating serine racemase and d-amino acid oxidase expression in the mouse striatum. Brain Res. 2021 01 15; 1751:147202. PMID: 33171153; PMCID: PMC8753929.
    Citations: 2     Fields:    Translation:Animals
  10. Wong JM, Folorunso OO, Barragan EV, Berciu C, Harvey TL, Coyle JT, Balu DT, Gray JA. Postsynaptic Serine Racemase Regulates NMDA Receptor Function. J Neurosci. 2020 12 09; 40(50):9564-9575. PMID: 33158959.
    Citations: 11     Fields:    Translation:AnimalsCells
  11. Ni P, Noh H, Park GH, Shao Z, Guan Y, Park JM, Yu S, Park JS, Coyle JT, Weinberger DR, Straub RE, Cohen BM, McPhie DL, Yin C, Huang W, Kim HY, Chung S. Correction: iPSC-derived homogeneous populations of developing schizophrenia cortical interneurons have compromised mitochondrial function. Mol Psychiatry. 2020 Nov; 25(11):3103-3104. PMID: 31366918.
    Citations: 1     Fields:    
  12. Park GH, Noh H, Shao Z, Ni P, Qin Y, Liu D, Beaudreault CP, Park JS, Abani CP, Park JM, Le DT, Gonzalez SZ, Guan Y, Cohen BM, McPhie DL, Coyle JT, Lanz TA, Xi HS, Yin C, Huang W, Kim HY, Chung S. Activated microglia cause metabolic disruptions in developmental cortical interneurons that persist in interneurons from individuals with schizophrenia. Nat Neurosci. 2020 11; 23(11):1352-1364. PMID: 33097921.
    Citations: 17     Fields:    Translation:HumansCells
  13. Coyle JT, Schwarcz R. The Discovery and Characterization of Targeted Perikaryal-Specific Brain Lesions With Excitotoxins. Front Neurosci. 2020; 14:927. PMID: 33013307.
    Citations:    
  14. Takagi S, Puhl MD, Anderson T, Balu DT, Coyle JT. Serine Racemase Expression by Striatal Neurons. Cell Mol Neurobiol. 2022 Jan; 42(1):279-289. PMID: 32445040; PMCID: PMC7680280.
    Citations: 4     Fields:    Translation:AnimalsCells
  15. Coyle JT, Balu D, Wolosker H. D-Serine, the Shape-Shifting NMDA Receptor Co-agonist. Neurochem Res. 2020 Jun; 45(6):1344-1353. PMID: 32189130.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  16. Torres Jimenez N, Lines JW, Kueppers RB, Kofuji P, Wei H, Rankila A, Coyle JT, Miller RF, McLoon LK. Electroretinographic Abnormalities and Sex Differences Detected with Mesopic Adaptation in a Mouse Model of Schizophrenia: A and B Wave Analysis. Invest Ophthalmol Vis Sci. 2020 02 07; 61(2):16. PMID: 32053730; PMCID: PMC7326504.
    Citations: 3     Fields:    Translation:Animals
  17. Balu DT, Pantazopoulos H, Huang CCY, Muszynski K, Harvey TL, Uno Y, Rorabaugh JM, Galloway CR, Botz-Zapp C, Berretta S, Weinshenker D, Coyle JT. Neurotoxic astrocytes express the d-serine synthesizing enzyme, serine racemase, in Alzheimer's disease. Neurobiol Dis. 2019 10; 130:104511. PMID: 31212068; PMCID: PMC6689433.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  18. Bodkin JA, Coleman MJ, Godfrey LJ, Carvalho CMB, Morgan CJ, Suckow RF, Anderson T, Öngür D, Kaufman MJ, Lewandowski KE, Siegel AJ, Waldstreicher E, Grochowski CM, Javitt DC, Rujescu D, Hebbring S, Weinshilboum R, Rodriguez SB, Kirchhoff C, Visscher T, Vuckovic A, Fialkowski A, McCarthy S, Malhotra D, Sebat J, Goff DC, Hudson JI, Lupski JR, Coyle JT, Rudolph U, Levy DL. Targeted Treatment of Individuals With Psychosis Carrying a Copy Number Variant Containing a Genomic Triplication of the Glycine Decarboxylase Gene. Biol Psychiatry. 2019 10 01; 86(7):523-535. PMID: 31279534; PMCID: PMC6745274.
    Citations: 17     Fields:    Translation:HumansCTClinical Trials
  19. Ni P, Noh H, Park GH, Shao Z, Guan Y, Park JM, Yu S, Park JS, Coyle JT, Weinberger DR, Straub RE, Cohen BM, McPhie DL, Yin C, Huang W, Kim HY, Chung S. iPSC-derived homogeneous populations of developing schizophrenia cortical interneurons have compromised mitochondrial function. Mol Psychiatry. 2020 11; 25(11):2873-2888. PMID: 31019265.
    Citations: 22     Fields:    Translation:HumansCells
  20. Uno Y, Coyle JT. Glutamate hypothesis in schizophrenia. Psychiatry Clin Neurosci. 2019 May; 73(5):204-215. PMID: 30666759.
    Citations: 85     Fields:    Translation:HumansAnimals
  21. Gicquelais RE, Foxman B, Coyle J, Eisenberg MC. Hepatitis C transmission in young people who inject drugs: Insights using a dynamic model informed by state public health surveillance. Epidemics. 2019 06; 27:86-95. PMID: 30930214.
    Citations: 7     Fields:    Translation:HumansPHPublic Health
  22. Mothet JP, Billard JM, Pollegioni L, Coyle JT, Sweedler JV. Investigating brain d-serine: Advocacy for good practices. Acta Physiol (Oxf). 2019 05; 226(1):e13257. PMID: 30650253.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  23. Shao Z, Noh H, Bin Kim W, Ni P, Nguyen C, Cote SE, Noyes E, Zhao J, Parsons T, Park JM, Zheng K, Park JJ, Coyle JT, Weinberger DR, Straub RE, Berman KF, Apud J, Ongur D, Cohen BM, McPhie DL, Rapoport JL, Perlis RH, Lanz TA, Xi HS, Yin C, Huang W, Hirayama T, Fukuda E, Yagi T, Ghosh S, Eggan KC, Kim HY, Eisenberg LM, Moghadam AA, Stanton PK, Cho JH, Chung S. Dysregulated protocadherin-pathway activity as an intrinsic defect in induced pluripotent stem cell-derived cortical interneurons from subjects with schizophrenia. Nat Neurosci. 2019 02; 22(2):229-242. PMID: 30664768; PMCID: PMC6373728.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  24. Konopaske GT, Balu DT, Presti KT, Chan G, Benes FM, Coyle JT. Dysbindin-1 contributes to prefrontal cortical dendritic arbor pathology in schizophrenia. Schizophr Res. 2018 11; 201:270-277. PMID: 29759351; PMCID: PMC6230503.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  25. Ruzicka WB, Subburaju S, Coyle JT, Benes FM. Location matters: distinct DNA methylation patterns in GABAergic interneuronal populations from separate microcircuits within the human hippocampus. Hum Mol Genet. 2018 01 15; 27(2):254-265. PMID: 29106556; PMCID: PMC5886141.
    Citations: 4     Fields:    Translation:HumansCells
  26. Li S, Uno Y, Rudolph U, Cobb J, Liu J, Anderson T, Levy D, Balu DT, Coyle JT. Astrocytes in primary cultures express serine racemase, synthesize d-serine and acquire A1 reactive astrocyte features. Biochem Pharmacol. 2018 05; 151:245-251. PMID: 29305854; PMCID: PMC5899945.
    Citations: 19     Fields:    Translation:AnimalsCells
  27. Coyle JT, Balu DT. The Role of Serine Racemase in the Pathophysiology of Brain Disorders. Adv Pharmacol. 2018; 82:35-56. PMID: 29413527; PMCID: PMC5821497.
    Citations: 18     Fields:    Translation:HumansAnimals
  28. Balu DT, Coyle JT. Altered CREB Binding to Activity-Dependent Genes in Serine Racemase Deficient Mice, a Mouse Model of Schizophrenia. ACS Chem Neurosci. 2018 09 19; 9(9):2205-2209. PMID: 29172439; PMCID: PMC5971149.
    Citations: 1     Fields:    Translation:Animals
  29. Puhl MD, Desai RI, Takagi S, Presti KT, Doyle MR, Donahue RJ, Landino SM, Bergman J, Carlezon WA, Coyle JT. N-Methyl-d-aspartate receptor co-agonist availability affects behavioral and neurochemical responses to cocaine: insights into comorbid schizophrenia and substance abuse. Addict Biol. 2019 01; 24(1):40-50. PMID: 29168271.
    Citations: 7     Fields:    Translation:Animals
  30. Kim SY, Kaufman MJ, Cohen BM, Jensen JE, Coyle JT, Du F, Öngür D. In Vivo Brain Glycine and Glutamate Concentrations in Patients With First-Episode Psychosis Measured by Echo Time-Averaged Proton Magnetic Resonance Spectroscopy at 4T. Biol Psychiatry. 2018 03 15; 83(6):484-491. PMID: 29031411; PMCID: PMC5809251.
    Citations: 12     Fields:    Translation:Humans
  31. Balu DT, Presti KT, Huang CCY, Muszynski K, Radzishevsky I, Wolosker H, Guffanti G, Ressler KJ, Coyle JT. Serine Racemase and D-serine in the Amygdala Are Dynamically Involved in Fear Learning. Biol Psychiatry. 2018 02 01; 83(3):273-283. PMID: 29025687; PMCID: PMC5806199.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  32. Wolosker H, Balu DT, Coyle JT. Astroglial Versus Neuronal D-Serine: Check Your Controls! Trends Neurosci. 2017 09; 40(9):520-522. PMID: 28756007; PMCID: PMC5810374.
    Citations: 14     Fields:    Translation:HumansCells
  33. Perez EJ, Tapanes SA, Loris ZB, Balu DT, Sick TJ, Coyle JT, Liebl DJ. Enhanced astrocytic d-serine underlies synaptic damage after traumatic brain injury. J Clin Invest. 2017 Aug 01; 127(8):3114-3125. PMID: 28714867; PMCID: PMC5531405.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  34. Noh H, Shao Z, Coyle JT, Chung S. Modeling schizophrenia pathogenesis using patient-derived induced pluripotent stem cells (iPSCs). Biochim Biophys Acta Mol Basis Dis. 2017 09; 1863(9):2382-2387. PMID: 28668333; PMCID: PMC5737829.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  35. Coyle JT. Cortical Pyramidal Neurons Show a Selective Loss of New Synapses in Chronic Schizophrenia. Am J Psychiatry. 2017 06 01; 174(6):510-511. PMID: 28565949.
    Citations: 2     Fields:    Translation:HumansCells
  36. Tobe BTD, Crain AM, Winquist AM, Calabrese B, Makihara H, Zhao WN, Lalonde J, Nakamura H, Konopaske G, Sidor M, Pernia CD, Yamashita N, Wada M, Inoue Y, Nakamura F, Sheridan SD, Logan RW, Brandel M, Wu D, Hunsberger J, Dorsett L, Duerr C, Basa RCB, McCarthy MJ, Udeshi ND, Mertins P, Carr SA, Rouleau GA, Mastrangelo L, Li J, Gutierrez GJ, Brill LM, Venizelos N, Chen G, Nye JS, Manji H, Price JH, McClung CA, Akiskal HS, Alda M, Chuang DM, Coyle JT, Liu Y, Teng YD, Ohshima T, Mikoshiba K, Sidman RL, Halpain S, Haggarty SJ, Goshima Y, Snyder EY. Probing the lithium-response pathway in hiPSCs implicates the phosphoregulatory set-point for a cytoskeletal modulator in bipolar pathogenesis. Proc Natl Acad Sci U S A. 2017 05 30; 114(22):E4462-E4471. PMID: 28500272; PMCID: PMC5465887.
    Citations: 56     Fields:    Translation:HumansAnimalsCells
  37. Coyle JT. Schizophrenia: Basic and Clinical. Adv Neurobiol. 2017; 15:255-280. PMID: 28674984.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  38. Wolosker H, Balu DT, Coyle JT. The Rise and Fall of the d-Serine-Mediated Gliotransmission Hypothesis. Trends Neurosci. 2016 11; 39(11):712-721. PMID: 27742076; PMCID: PMC5113294.
    Citations: 73     Fields:    Translation:HumansAnimalsCells
  39. Basu AC, Puhl MD, Coyle JT. Endogenous co-agonists of the NMDA receptor modulate contextual fear in trace conditioning. Neurobiol Learn Mem. 2016 Dec; 136:244-250. PMID: 27633914.
    Citations: 2     Fields:    Translation:Animals
  40. Coyle JT, Konopaske G. Glutamatergic Dysfunction in Schizophrenia Evaluated With Magnetic Resonance Spectroscopy. JAMA Psychiatry. 2016 07 01; 73(7):649-50. PMID: 27305626.
    Citations: 3     Fields:    Translation:Humans
  41. Perez EJ, Cepero ML, Perez SU, Coyle JT, Sick TJ, Liebl DJ. EphB3 signaling propagates synaptic dysfunction in the traumatic injured brain. Neurobiol Dis. 2016 Oct; 94:73-84. PMID: 27317833; PMCID: PMC5662938.
    Citations: 14     Fields:    Translation:AnimalsCells
  42. Coyle JT. My Life in Clinical Neuroscience: The Beginning. Adv Pharmacol. 2016; 76:1-12. PMID: 27288071.
    Citations:    Fields:    Translation:Humans
  43. Coyle JT, Balu DT, Puhl MD, Konopaske GT. History of the Concept of Disconnectivity in Schizophrenia. Harv Rev Psychiatry. 2016 Mar-Apr; 24(2):80-6. PMID: 26954593.
    Citations: 14     Fields:    Translation:HumansCells
  44. Kangas BD, Bergman J, Coyle JT. Touchscreen assays of learning, response inhibition, and motivation in the marmoset (Callithrix jacchus). Anim Cogn. 2016 May; 19(3):673-7. PMID: 26846231.
    Citations: 7     Fields:    Translation:Animals
  45. Balu DT, Li Y, Takagi S, Presti KT, Ramikie TS, Rook JM, Jones CK, Lindsley CW, Conn PJ, Bolshakov VY, Coyle JT. An mGlu5-Positive Allosteric Modulator Rescues the Neuroplasticity Deficits in a Genetic Model of NMDA Receptor Hypofunction in Schizophrenia. Neuropsychopharmacology. 2016 07; 41(8):2052-61. PMID: 26741285.
    Citations: 27     Fields:    Translation:AnimalsCells
  46. Konopaske GT, Coyle JT. Possible compensatory mechanisms for glutamatergic disconnection found in the auditory cortex in schizophrenia. Biol Psychiatry. 2015 Jun 01; 77(11):923-4. PMID: 25959563; PMCID: PMC4806226.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  47. Puhl MD, Berg AR, Bechtholt AJ, Coyle JT. Availability of N-Methyl-d-Aspartate Receptor Coagonists Affects Cocaine-Induced Conditioned Place Preference and Locomotor Sensitization: Implications for Comorbid Schizophrenia and Substance Abuse. J Pharmacol Exp Ther. 2015 Jun; 353(3):465-70. PMID: 25788713; PMCID: PMC4429674.
    Citations: 6     Fields:    Translation:Animals
  48. Ishiwata S, Umino A, Balu DT, Coyle JT, Nishikawa T. Neuronal serine racemase regulates extracellular D-serine levels in the adult mouse hippocampus. J Neural Transm (Vienna). 2015 Aug; 122(8):1099-103. PMID: 25782690.
    Citations: 12     Fields:    Translation:AnimalsCells
  49. Konopaske GT, Subburaju S, Coyle JT, Benes FM. Altered prefrontal cortical MARCKS and PPP1R9A mRNA expression in schizophrenia and bipolar disorder. Schizophr Res. 2015 May; 164(1-3):100-8. PMID: 25757715; PMCID: PMC4409526.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  50. Takagi S, Balu DT, Coyle JT. Subchronic pharmacological and chronic genetic NMDA receptor hypofunction differentially regulate the Akt signaling pathway and Arc expression in juvenile and adult mice. Schizophr Res. 2015 Mar; 162(1-3):216-21. PMID: 25592804; PMCID: PMC4339465.
    Citations: 6     Fields:    Translation:AnimalsCells
  51. Balu DT, Coyle JT. The NMDA receptor 'glycine modulatory site' in schizophrenia: D-serine, glycine, and beyond. Curr Opin Pharmacol. 2015 Feb; 20:109-15. PMID: 25540902.
    Citations: 89     Fields:    Translation:HumansAnimalsCells
  52. Coyle JT. Farewell. JAMA Psychiatry. 2014 Dec 1; 71(12):1321-2. PMID: 25470990.
    Citations:    
  53. Konopaske GT, Lange N, Coyle JT, Benes FM. Prefrontal cortical dendritic spine pathology in schizophrenia and bipolar disorder. JAMA Psychiatry. 2014 Dec 01; 71(12):1323-31. PMID: 25271938; PMCID: PMC5510541.
    Citations: 163     Fields:    Translation:HumansAnimalsCells
  54. Zhang S, Wang S, Puhl MD, Jiang X, Hyrc KL, Laciny E, Wallendorf MJ, Pappan KL, Coyle JT, Wice BM. Global biochemical profiling identifies ß-hydroxypyruvate as a potential mediator of type 2 diabetes in mice and humans. Diabetes. 2015 Apr; 64(4):1383-94. PMID: 25368100; PMCID: PMC4375086.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  55. Puhl MD, Mintzopoulos D, Jensen JE, Gillis TE, Konopaske GT, Kaufman MJ, Coyle JT. In vivo magnetic resonance studies reveal neuroanatomical and neurochemical abnormalities in the serine racemase knockout mouse model of schizophrenia. Neurobiol Dis. 2015 Jan; 73:269-74. PMID: 25461193; PMCID: PMC4408217.
    Citations: 20     Fields:    Translation:Animals
  56. Balu DT, Coyle JT. Chronic D-serine reverses arc expression and partially rescues dendritic abnormalities in a mouse model of NMDA receptor hypofunction. Neurochem Int. 2014 Sep; 75:76-8. PMID: 24915645.
    Citations: 21     Fields:    Translation:Animals
  57. Balu DT, Takagi S, Puhl MD, Benneyworth MA, Coyle JT. D-serine and serine racemase are localized to neurons in the adult mouse and human forebrain. Cell Mol Neurobiol. 2014 Apr; 34(3):419-35. PMID: 24436034.
    Citations: 59     Fields:    Translation:HumansAnimalsCells
  58. Santini MA, Balu DT, Puhl MD, Hill-Smith TE, Berg AR, Lucki I, Mikkelsen JD, Coyle JT. D-serine deficiency attenuates the behavioral and cellular effects induced by the hallucinogenic 5-HT(2A) receptor agonist DOI. Behav Brain Res. 2014 Feb 01; 259:242-6. PMID: 24269270.
    Citations: 2     Fields:    Translation:Animals
  59. Coyle JT, Ongur D. Relapse in alcohol use disorder--reply. JAMA Psychiatry. 2013 Nov; 70(11):1248. PMID: 24196497.
    Citations:    Fields:    Translation:Humans
  60. O'Connor JE, Coyle J, Bogue C, Spence LD, Last J. Age prediction formulae from radiographic assessment of skeletal maturation at the knee in an Irish population. Forensic Sci Int. 2014 Jan; 234:188.e1-8. PMID: 24262807.
    Citations: 9     Fields:    Translation:Humans
  61. Coyle JT. Brain structural alterations induced by fetal exposure to cocaine persist into adolescence and affect behavior. JAMA Psychiatry. 2013 Oct; 70(10):1113-4. PMID: 23986322.
    Citations: 2     Fields:    Translation:Humans
  62. Coyle JT. Nitric oxide and symptom reduction in schizophrenia. JAMA Psychiatry. 2013 Jul; 70(7):664-5. PMID: 23699799.
    Citations: 5     Fields:    Translation:Humans
  63. Balu DT, Li Y, Puhl MD, Benneyworth MA, Basu AC, Takagi S, Bolshakov VY, Coyle JT. Multiple risk pathways for schizophrenia converge in serine racemase knockout mice, a mouse model of NMDA receptor hypofunction. Proc Natl Acad Sci U S A. 2013 Jun 25; 110(26):E2400-9. PMID: 23729812.
    Citations: 108     Fields:    Translation:HumansAnimalsCells
  64. Konopaske GT, Bolo NR, Basu AC, Renshaw PF, Coyle JT. Time-dependent effects of haloperidol on glutamine and GABA homeostasis and astrocyte activity in the rat brain. Psychopharmacology (Berl). 2013 Nov; 230(1):57-67. PMID: 23660600.
    Citations: 8     Fields:    Translation:AnimalsCells
  65. Coyle JT. Much more than a name change. JAMA Psychiatry. 2013 Jan; 70(1):8. PMID: 23303609.
    Citations:    Fields:    Translation:Humans
  66. Li Y, Sacchi S, Pollegioni L, Basu AC, Coyle JT, Bolshakov VY. Identity of endogenous NMDAR glycine site agonist in amygdala is determined by synaptic activity level. Nat Commun. 2013; 4:1760. PMID: 23612301.
    Citations: 40     Fields:    Translation:AnimalsCells
  67. Saalau-Bethell SM, Woodhead AJ, Chessari G, Carr MG, Coyle J, Graham B, Hiscock SD, Murray CW, Pathuri P, Rich SJ, Richardson CJ, Williams PA, Jhoti H. Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function. Nat Chem Biol. 2012 Nov; 8(11):920-5. PMID: 23023261.
    Citations: 44     Fields:    Translation:Cells
  68. Coyle JT. NMDA receptor and schizophrenia: a brief history. Schizophr Bull. 2012 Sep; 38(5):920-6. PMID: 22987850; PMCID: PMC3446237.
    Citations: 156     Fields:    Translation:HumansAnimals
  69. Bauchner H, Albert DM, Coyle JT, Freischlag JA, Larrabee WF, Levine PA, Redberg RF, Rivara FP, Robinson JK, Rosenberg RN. The JAMA network journals: new names for the archives journals. Arch Intern Med. 2012 Jul 23; 172(14):1056. PMID: 22751685.
    Citations:    Fields:    Translation:Humans
  70. Benneyworth MA, Coyle JT. Altered acquisition and extinction of amphetamine-paired context conditioning in genetic mouse models of altered NMDA receptor function. Neuropsychopharmacology. 2012 Oct; 37(11):2496-504. PMID: 22763616.
    Citations: 10     Fields:    Translation:AnimalsCells
  71. Bauchner H, Albert DM, Coyle JT, Freischlag JA, Larrabee WF, Levine PA, Redberg RF, Redberg RA, Rivara FP, Robinson JK, Rosenberg RN. The JAMA Network Journals: new names for the archives journals. Arch Dermatol. 2012 Jul; 148(7):788. PMID: 22751861.
    Citations:    Fields:    Translation:Humans
  72. Bauchner H, Albert DM, Coyle JT, Freischlag JA, Larrabee WF, Levine PA, Redberg RA, Rivara FP, Robinson JK, Rosenberg RN. The JAMA Network Journals: new names for the archives journals. Arch Pediatr Adolesc Med. 2012 Jul 01; 166(7):662. PMID: 22751884.
    Citations:    Fields:    Translation:Humans
  73. Bauchner H, Albert DM, Coyle JT, Freischlag JA, Larrabee WF, Levine PA, Redberg RF, Redberg RA, Rivara FP, Robinson JK, Rosenberg RN. The JAMA Network journals: new names for the archives journals. Arch Facial Plast Surg. 2012 Jul-Aug; 14(4):236. PMID: 22751939.
    Citations:    Fields:    Translation:Humans
  74. Bauchner H, Albert DM, Coyle JT, Freischlag JA, Larrabee WF, Levine PA, Redberg RA, Rivara FP, Robinson JK, Rosenberg RN. The JAMA Network journals: new names for the archives journals. Arch Surg. 2012 Jul; 147(7):587. PMID: 22802053.
    Citations:    Fields:    Translation:Humans
  75. Coyle JT. Changing to JAMA Psychiatry. Arch Gen Psychiatry. 2012 Jul 1; 69(7):661. PMID: 23117594.
    Citations:    
  76. Bauchner H, Albert DM, Coyle JT, Freischlag JA, Larrabee WF, Levine PA, Redberg RF, Rivara FP, Robinson JK, Rosenberg RN. The JAMA Network Journals: New Names for the Archives Journals. Arch Gen Psychiatry. 2012 Jul 01; 69(7):660. PMID: 23754012.
    Citations:    Fields:    
  77. Coyle JT. Changing to JAMA Psychiatry. Arch Gen Psychiatry. 2012 Jul 01; 69(7):661. PMID: 23754033.
    Citations:    Fields:    
  78. Bauchner H, Albert DM, Coyle JT, Freischlag JA, Larrabee WF, Levine PA, Redberg RF, Rivara FP, Robinson JK, Rosenberg RN. The JAMA Network Journals: New Names for the Archives Journals. Arch Neurol. 2012 Jul; 69(7):817. PMID: 23403866.
    Citations:    Fields:    
  79. Bauchner H, Albert DM, Coyle JT, Freischlag JA, Larrabee WF, Levine PA, Redberg RF, Rivara FP, Robinson JK, Rosenberg RN. The JAMA Network Journals: New Names for the Archives Journals. Arch Ophthalmol. 2012 Jul; 130(7):914. PMID: 23403910.
    Citations:    Fields:    
  80. Bauchner H, Albert DM, Coyle JT, Freischlag JA, Larrabee WF, Levine PA, Redberg RA, Rivara FP, Robinson JK, Rosenberg RN. The JAMA Network Journals: New Names for the Archives Journals. Arch Neurol. 2012 Jul 1; 69(7):817. PMID: 22772586.
    Citations:    
  81. Bauchner H, Albert DM, Coyle JT, Freischlag JA, Larrabee WF, Levine PA, Redberg RF, Rivara FP, Robinson JK, Rosenberg RN. The JAMA Network Journals: New Names for the Archives Journals. Arch Otolaryngol Head Neck Surg. 2012 Jul 01; 138(7):620. PMID: 23753751.
    Citations:    Fields:    
  82. Schaevitz LR, Picker JD, Rana J, Kolodny NH, Shane B, Berger-Sweeney JE, Coyle JT. Glutamate carboxypeptidase II and folate deficiencies result in reciprocal protection against cognitive and social deficits in mice: implications for neurodevelopmental disorders. Dev Neurobiol. 2012 Jun; 72(6):891-905. PMID: 22076974.
    Citations: 4     Fields:    Translation:Animals
  83. Coyle JT. Changes in JAMA and the Archives of General Psychiatry: what they mean for readers and authors. Arch Gen Psychiatry. 2012 May; 69(5):447-8. PMID: 22566577.
    Citations:    Fields:    
  84. Balu DT, Coyle JT. Neuronal D-serine regulates dendritic architecture in the somatosensory cortex. Neurosci Lett. 2012 May 31; 517(2):77-81. PMID: 22521586.
    Citations: 28     Fields:    Translation:AnimalsCells
  85. Coyle JT. Reviewers Who Completed a Review During 2011. Arch Gen Psychiatry. 2012 Apr 01; 69(4):E1-E8. PMID: 29138792.
    Citations:    Fields:    
  86. Benneyworth MA, Li Y, Basu AC, Bolshakov VY, Coyle JT. Cell selective conditional null mutations of serine racemase demonstrate a predominate localization in cortical glutamatergic neurons. Cell Mol Neurobiol. 2012 May; 32(4):613-24. PMID: 22362148.
    Citations: 67     Fields:    Translation:AnimalsCells
  87. Chen Y, Norton DJ, McBain R, Gold J, Frazier JA, Coyle JT. Enhanced local processing of dynamic visual information in autism: evidence from speed discrimination. Neuropsychologia. 2012 Apr; 50(5):733-9. PMID: 22261399.
    Citations: 18     Fields:    Translation:Humans
  88. Bergeron R, Coyle JT. NAAG, NMDA receptor and psychosis. Curr Med Chem. 2012; 19(9):1360-4. PMID: 22304714.
    Citations: 19     Fields:    Translation:HumansAnimals
  89. Coyle JT, Basu A, Benneyworth M, Balu D, Konopaske G. Glutamatergic synaptic dysregulation in schizophrenia: therapeutic implications. Handb Exp Pharmacol. 2012; (213):267-95. PMID: 23027419.
    Citations: 70     Fields:    Translation:HumansAnimalsCells
  90. Sullivan SJ, Esguerra M, Wickham RJ, Romero GE, Coyle JT, Miller RF. Serine racemase deletion abolishes light-evoked NMDA receptor currents in retinal ganglion cells. J Physiol. 2011 Dec 15; 589(Pt 24):5997-6006. PMID: 22041185.
    Citations: 11     Fields:    Translation:AnimalsCells
  91. Balu DT, Basu AC, Corradi JP, Cacace AM, Coyle JT. The NMDA receptor co-agonists, D-serine and glycine, regulate neuronal dendritic architecture in the somatosensory cortex. Neurobiol Dis. 2012 Feb; 45(2):671-82. PMID: 22024716.
    Citations: 47     Fields:    Translation:AnimalsCells
  92. Balu DT, Coyle JT. Glutamate receptor composition of the post-synaptic density is altered in genetic mouse models of NMDA receptor hypo- and hyperfunction. Brain Res. 2011 May 25; 1392:1-7. PMID: 21443867; PMCID: PMC3225000.
    Citations: 22     Fields:    Translation:AnimalsCells
  93. Coyle JT. Online first. Arch Gen Psychiatry. 2011 Apr 4; 68(4):339. PMID: 22639041.
    Citations:    
  94. Benneyworth MA, Roseman AS, Basu AC, Coyle JT. Failure of NMDA receptor hypofunction to induce a pathological reduction in PV-positive GABAergic cell markers. Neurosci Lett. 2011 Jan 25; 488(3):267-71. PMID: 21094213.
    Citations: 15     Fields:    Translation:AnimalsCells
  95. DeVito LM, Balu DT, Kanter BR, Lykken C, Basu AC, Coyle JT, Eichenbaum H. Serine racemase deletion disrupts memory for order and alters cortical dendritic morphology. Genes Brain Behav. 2011 Mar; 10(2):210-22. PMID: 21029376.
    Citations: 60     Fields:    Translation:AnimalsCells
  96. Balu DT, Coyle JT. Neuroplasticity signaling pathways linked to the pathophysiology of schizophrenia. Neurosci Biobehav Rev. 2011 Jan; 35(3):848-70. PMID: 20951727.
    Citations: 76     Fields:    Translation:HumansAnimalsCells
  97. Benneyworth MA, Basu AC, Coyle JT. Discordant behavioral effects of psychotomimetic drugs in mice with altered NMDA receptor function. Psychopharmacology (Berl). 2011 Jan; 213(1):143-53. PMID: 20865248.
    Citations: 3     Fields:    Translation:Animals
  98. Mustafa AK, Ahmad AS, Zeynalov E, Gazi SK, Sikka G, Ehmsen JT, Barrow RK, Coyle JT, Snyder SH, Doré S. Serine racemase deletion protects against cerebral ischemia and excitotoxicity. J Neurosci. 2010 Jan 27; 30(4):1413-6. PMID: 20107067.
    Citations: 36     Fields:    Translation:AnimalsCells
  99. Coyle JT, Balu D, Benneyworth M, Basu A, Roseman A. Beyond the dopamine receptor: novel therapeutic targets for treating schizophrenia. Dialogues Clin Neurosci. 2010; 12(3):359-82. PMID: 20954431.
    Citations: 27     Fields:    Translation:HumansAnimals
  100. Reed BT, Sullivan SJ, Tsai G, Coyle JT, Esguerra M, Miller RF. The glycine transporter GlyT1 controls N-methyl-D-aspartic acid receptor coagonist occupancy in the mouse retina. Eur J Neurosci. 2009 Dec; 30(12):2308-17. PMID: 20092573.
    Citations: 11     Fields:    Translation:AnimalsCells
  101. Han L, Picker JD, Schaevitz LR, Tsai G, Feng J, Jiang Z, Chu HC, Basu AC, Berger-Sweeney J, Coyle JT. Phenotypic characterization of mice heterozygous for a null mutation of glutamate carboxypeptidase II. Synapse. 2009 Aug; 63(8):625-35. PMID: 19347959.
    Citations: 11     Fields:    Translation:Animals
  102. Ghose S, Chin R, Gallegos A, Roberts R, Coyle J, Tamminga C. Localization of NAAG-related gene expression deficits to the anterior hippocampus in schizophrenia. Schizophr Res. 2009 Jun; 111(1-3):131-7. PMID: 19403271.
    Citations: 17     Fields:    Translation:HumansCells
  103. Coyle JT. MicroRNAs suggest a new mechanism for altered brain gene expression in schizophrenia. Proc Natl Acad Sci U S A. 2009 Mar 03; 106(9):2975-6. PMID: 19251669.
    Citations: 10     Fields:    Translation:AnimalsCells
  104. Basu AC, Tsai GE, Ma CL, Ehmsen JT, Mustafa AK, Han L, Jiang ZI, Benneyworth MA, Froimowitz MP, Lange N, Snyder SH, Bergeron R, Coyle JT. Targeted disruption of serine racemase affects glutamatergic neurotransmission and behavior. Mol Psychiatry. 2009 Jul; 14(7):719-27. PMID: 19065142.
    Citations: 139     Fields:    Translation:AnimalsCells
  105. Coyle JT. Erratum: "Prevalence, heritability, and prospective risk factors for anorexia nervosa" (2006;63[3]:305-312). Arch Gen Psychiatry. 2008 Sep; 65(9):994. PMID: 18762585.
    Citations:    Fields:    Translation:Humans
  106. Regenberg A, Mathews DJ, Blass DM, Bok H, Coyle JT, Duggan P, Faden R, Finkel J, Gearhart JD, Hillis A, Hoke A, Johnson R, Johnston M, Kahn J, Kerr D, King P, Kurtzberg J, Liao SM, McDonald JW, McKhann G, Nelson KB, Rao M, Siegel AW, Smith K, Solter D, Song H, Sugarman J, Vescovi A, Young W, Greely HT, Traystman RJ. The role of animal models in evaluating reasonable safety and efficacy for human trials of cell-based interventions for neurologic conditions. J Cereb Blood Flow Metab. 2009 Jan; 29(1):1-9. PMID: 18728679.
    Citations: 13     Fields:    Translation:HumansAnimals
  107. Lisman JE, Coyle JT, Green RW, Javitt DC, Benes FM, Heckers S, Grace AA. Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia. Trends Neurosci. 2008 May; 31(5):234-42. PMID: 18395805.
    Citations: 468     Fields:    Translation:HumansAnimals
  108. Eaton DL, Daroff RB, Autrup H, Bridges J, Buffler P, Costa LG, Coyle J, McKhann G, Mobley WC, Nadel L, Neubert D, Schulte-Hermann R, Spencer PS. Review of the toxicology of chlorpyrifos with an emphasis on human exposure and neurodevelopment. Crit Rev Toxicol. 2008; 38 Suppl 2:1-125. PMID: 18726789.
    Citations: 147     Fields:    Translation:HumansAnimalsPHPublic Health
  109. Lawson-Yuen A, Liu D, Han L, Jiang ZI, Tsai GE, Basu AC, Picker J, Feng J, Coyle JT. Ube3a mRNA and protein expression are not decreased in Mecp2R168X mutant mice. Brain Res. 2007 Nov 14; 1180:1-6. PMID: 17936729.
    Citations: 34     Fields:    Translation:Animals
  110. Han L, Wong DL, Tsai G, Jiang Z, Coyle JT. Promoter analysis of human glutamate carboxypeptidase II. Brain Res. 2007 Sep 19; 1170:1-12. PMID: 17689503; PMCID: PMC2706136.
    Citations: 3     Fields:    Translation:HumansCells
  111. Coyle JT, Geerts H, Sorra K, Amatniek J. Beyond in vitro data: a review of in vivo evidence regarding the allosteric potentiating effect of galantamine on nicotinic acetylcholine receptors in Alzheimer's neuropathology. J Alzheimers Dis. 2007 Jul; 11(4):491-507. PMID: 17656829.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  112. Coyle JT. What can a clock mutation in mice tell us about bipolar disorder? Proc Natl Acad Sci U S A. 2007 Apr 10; 104(15):6097-8. PMID: 17404212; PMCID: PMC1851026.
    Citations: 5     Fields:    Translation:Animals
  113. Bergeron R, Imamura Y, Frangioni JV, Greene RW, Coyle JT. Endogenous N-acetylaspartylglutamate reduced NMDA receptor-dependent current neurotransmission in the CA1 area of the hippocampus. J Neurochem. 2007 Jan; 100(2):346-57. PMID: 17241157.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  114. Coyle JT. Substance use disorders and Schizophrenia: a question of shared glutamatergic mechanisms. Neurotox Res. 2006 Dec; 10(3-4):221-33. PMID: 17197372.
    Citations: 28     Fields:    Translation:HumansAnimals
  115. Siekmeier PJ, Hasselmo ME, Howard MW, Coyle J. Modeling of context-dependent retrieval in hippocampal region CA1: implications for cognitive function in schizophrenia. Schizophr Res. 2007 Jan; 89(1-3):177-90. PMID: 17055702.
    Citations: 17     Fields:    Translation:Humans
  116. Ross CA, Margolis RL, Reading SA, Pletnikov M, Coyle JT. Neurobiology of schizophrenia. Neuron. 2006 Oct 05; 52(1):139-53. PMID: 17015232.
    Citations: 257     Fields:    Translation:HumansAnimalsCells
  117. Coyle JT. Glutamate and schizophrenia: beyond the dopamine hypothesis. Cell Mol Neurobiol. 2006 Jul-Aug; 26(4-6):365-84. PMID: 16773445.
    Citations: 351     Fields:    Translation:HumansAnimalsCells
  118. Frye MA, Tsai GE, Huggins T, Coyle JT, Post RM. Low cerebrospinal fluid glutamate and glycine in refractory affective disorder. Biol Psychiatry. 2007 Jan 15; 61(2):162-6. PMID: 16735030.
    Citations: 38     Fields:    Translation:Humans
  119. Coyle JT. A brief overview of N-acetylaspartate and N-acetylaspartylglutamate. Adv Exp Med Biol. 2006; 576:1-6; discussion 361-3. PMID: 16802701.
    Citations: 1     Fields:    Translation:AnimalsCells
  120. Coyle JT. Glial metabolites of tryptophan and excitotoxicity: coming unglued. Exp Neurol. 2006 Jan; 197(1):4-7. PMID: 16300760.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  121. Picker JD, Coyle JT. Do maternal folate and homocysteine levels play a role in neurodevelopmental processes that increase risk for schizophrenia? Harv Rev Psychiatry. 2005 Jul-Aug; 13(4):197-205. PMID: 16126606.
    Citations: 24     Fields:    Translation:Humans
  122. Yurgelun-Todd DA, Coyle JT, Gruber SA, Renshaw PF, Silveri MM, Amico E, Cohen B, Goff DC. Functional magnetic resonance imaging studies of schizophrenic patients during word production: effects of D-cycloserine. Psychiatry Res. 2005 Jan 30; 138(1):23-31. PMID: 15708298.
    Citations: 16     Fields:    Translation:HumansCTClinical Trials
  123. Martina M, B-Turcotte ME, Halman S, Tsai G, Tiberi M, Coyle JT, Bergeron R. Reduced glycine transporter type 1 expression leads to major changes in glutamatergic neurotransmission of CA1 hippocampal neurones in mice. J Physiol. 2005 Mar 15; 563(Pt 3):777-93. PMID: 15661817; PMCID: PMC1665613.
    Citations: 23     Fields:    Translation:AnimalsCells
  124. Bergeron R, Coyle JT, Tsai G, Greene RW. NAAG reduces NMDA receptor current in CA1 hippocampal pyramidal neurons of acute slices and dissociated neurons. Neuropsychopharmacology. 2005 Jan; 30(1):7-16. PMID: 15354184.
    Citations: 28     Fields:    Translation:AnimalsCells
  125. Coyle JT. The GABA-glutamate connection in schizophrenia: which is the proximate cause? Biochem Pharmacol. 2004 Oct 15; 68(8):1507-14. PMID: 15451393.
    Citations: 70     Fields:    Translation:HumansAnimals
  126. Goff DC, Bottiglieri T, Arning E, Shih V, Freudenreich O, Evins AE, Henderson DC, Baer L, Coyle J. Folate, homocysteine, and negative symptoms in schizophrenia. Am J Psychiatry. 2004 Sep; 161(9):1705-8. PMID: 15337665.
    Citations: 33     Fields:    Translation:Humans
  127. Tsai G, Ralph-Williams RJ, Martina M, Bergeron R, Berger-Sweeney J, Dunham KS, Jiang Z, Caine SB, Coyle JT. Gene knockout of glycine transporter 1: characterization of the behavioral phenotype. Proc Natl Acad Sci U S A. 2004 Jun 01; 101(22):8485-90. PMID: 15159536; PMCID: PMC420420.
    Citations: 65     Fields:    Translation:AnimalsCells
  128. Ghose S, Weickert CS, Colvin SM, Coyle JT, Herman MM, Hyde TM, Kleinman JE. Glutamate carboxypeptidase II gene expression in the human frontal and temporal lobe in schizophrenia. Neuropsychopharmacology. 2004 Jan; 29(1):117-25. PMID: 14560319.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  129. Coyle JT, Tsai G. NMDA receptor function, neuroplasticity, and the pathophysiology of schizophrenia. Int Rev Neurobiol. 2004; 59:491-515. PMID: 15006500.
    Citations: 52     Fields:    Translation:HumansAnimals
  130. Javitt DC, Coyle JT. Decoding schizophrenia. Sci Am. 2004 Jan; 290(1):48-55. PMID: 14682038.
    Citations: 7     Fields:    Translation:HumansCells
  131. Tsai G, Dunham KS, Drager U, Grier A, Anderson C, Collura J, Coyle JT. Early embryonic death of glutamate carboxypeptidase II (NAALADase) homozygous mutants. Synapse. 2003 Dec 15; 50(4):285-92. PMID: 14556233.
    Citations: 9     Fields:    Translation:AnimalsCells
  132. Coyle JT, Pine DS, Charney DS, Lewis L, Nemeroff CB, Carlson GA, Joshi PT, Reiss D, Todd RD, Hellander M. Depression and bipolar support alliance consensus statement on the unmet needs in diagnosis and treatment of mood disorders in children and adolescents. J Am Acad Child Adolesc Psychiatry. 2003 Dec; 42(12):1494-503. PMID: 14627885.
    Citations: 19     Fields:    Translation:Humans
  133. Coyle JT, Tsai G. The NMDA receptor glycine modulatory site: a therapeutic target for improving cognition and reducing negative symptoms in schizophrenia. Psychopharmacology (Berl). 2004 Jun; 174(1):32-8. PMID: 15205876.
    Citations: 71     Fields:    Translation:HumansAnimals
  134. Coyle JT, Tsai G, Goff D. Converging evidence of NMDA receptor hypofunction in the pathophysiology of schizophrenia. Ann N Y Acad Sci. 2003 Nov; 1003:318-27. PMID: 14684455.
    Citations: 149     Fields:    Translation:Humans
  135. Coyle JT. Use it or lose it--do effortful mental activities protect against dementia? N Engl J Med. 2003 Jun 19; 348(25):2489-90. PMID: 12815133.
    Citations: 14     Fields:    Translation:Humans
  136. Coyle JT, Duman RS. Finding the intracellular signaling pathways affected by mood disorder treatments. Neuron. 2003 Apr 24; 38(2):157-60. PMID: 12718851.
    Citations: 92     Fields:    Translation:HumansAnimalsCells
  137. Flores C, Coyle JT. Regulation of glutamate carboxypeptidase II function in corticolimbic regions of rat brain by phencyclidine, haloperidol, and clozapine. Neuropsychopharmacology. 2003 Jul; 28(7):1227-34. PMID: 12700705.
    Citations: 7     Fields:    Translation:Animals
  138. Coyle JT. A continuing commitment to excellence. Arch Gen Psychiatry. 2002 Nov; 59(11):977. PMID: 12418929.
    Citations:    Fields:    Translation:Humans
  139. Coyle JT, Manji HK. Getting balance: drugs for bipolar disorder share target. Nat Med. 2002 Jun; 8(6):557-8. PMID: 12042799.
    Citations: 8     Fields:    Translation:HumansCells
  140. Coyle JT, Tsai G, Goff DC. Ionotropic glutamate receptors as therapeutic targets in schizophrenia. Curr Drug Targets CNS Neurol Disord. 2002 Apr; 1(2):183-9. PMID: 12769626.
    Citations: 39     Fields:    Translation:HumansAnimals
  141. Frazier JA, Doyle R, Chiu S, Coyle JT. Treating a child with Asperger's disorder and comorbid bipolar disorder. Am J Psychiatry. 2002 Jan; 159(1):13-21. PMID: 11772683.
    Citations: 6     Fields:    Translation:Humans
  142. Leski ML, Hassinger LC, Valentine SL, Baer JD, Coyle JT. L-type calcium channels reduce ROS generation in cerebellar granule cells following kainate exposure. Synapse. 2002 Jan; 43(1):30-41. PMID: 11746731.
    Citations:    Fields:    Translation:AnimalsCells
  143. Tsai G, Coyle JT. Glutamatergic mechanisms in schizophrenia. Annu Rev Pharmacol Toxicol. 2002; 42:165-79. PMID: 11807169.
    Citations: 175     Fields:    Translation:HumansAnimals
  144. Goff DC, Coyle JT. The emerging role of glutamate in the pathophysiology and treatment of schizophrenia. Am J Psychiatry. 2001 Sep; 158(9):1367-77. PMID: 11532718.
    Citations: 259     Fields:    Translation:HumansAnimalsCells
  145. Coyle J, Kershaw P. Galantamine, a cholinesterase inhibitor that allosterically modulates nicotinic receptors: effects on the course of Alzheimer's disease. Biol Psychiatry. 2001 Feb 01; 49(3):289-99. PMID: 11230880.
    Citations: 29     Fields:    Translation:HumansCells
  146. Leski ML, Valentine SL, Baer JD, Coyle JT. Insulin-like growth factor I prevents the development of sensitivity to kainate neurotoxicity in cerebellar granule cells. J Neurochem. 2000 Oct; 75(4):1548-56. PMID: 10987835.
    Citations: 5     Fields:    Translation:AnimalsCells
  147. Leveque JC, Macías W, Rajadhyaksha A, Carlson RR, Barczak A, Kang S, Li XM, Coyle JT, Huganir RL, Heckers S, Konradi C. Intracellular modulation of NMDA receptor function by antipsychotic drugs. J Neurosci. 2000 Jun 01; 20(11):4011-20. PMID: 10818136; PMCID: PMC4203343.
    Citations: 45     Fields:    Translation:AnimalsCells
  148. Nguyen TV, Brownell AL, Iris Chen YC, Livni E, Coyle JT, Rosen BR, Cavagna F, Jenkins BG. Detection of the effects of dopamine receptor supersensitivity using pharmacological MRI and correlations with PET. Synapse. 2000 Apr; 36(1):57-65. PMID: 10700026.
    Citations: 24     Fields:    Translation:Animals
  149. Price BH, Adams RD, Coyle JT. Neurology and psychiatry: closing the great divide. Neurology. 2000 Jan 11; 54(1):8-14. PMID: 10636118.
    Citations: 21     Fields:    Translation:Humans
  150. Coyle JT, Schwarcz R. Mind glue: implications of glial cell biology for psychiatry. Arch Gen Psychiatry. 2000 Jan; 57(1):90-3. PMID: 10632240.
    Citations: 28     Fields:    Translation:HumansCells
  151. Berger UV, Luthi-Carter R, Passani LA, Elkabes S, Black I, Konradi C, Coyle JT. Glutamate carboxypeptidase II is expressed by astrocytes in the adult rat nervous system. J Comp Neurol. 1999 Dec 06; 415(1):52-64. PMID: 10540357.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  152. Lindley CR, Coyle JT. Psychopharmacologist as family doctor: complications in the joint treatment of a husband and wife. Harv Rev Psychiatry. 1999 Nov-Dec; 7(4):222-9. PMID: 10579102.
    Citations:    Fields:    Translation:Humans
  153. Tsai GE, Yang P, Chung LC, Tsai IC, Tsai CW, Coyle JT. D-serine added to clozapine for the treatment of schizophrenia. Am J Psychiatry. 1999 Nov; 156(11):1822-5. PMID: 10553752.
    Citations: 52     Fields:    Translation:HumansCTClinical Trials
  154. Leski ML, Valentine SL, Coyle JT. L-type voltage-gated calcium channels modulate kainic acid neurotoxicity in cerebellar granule cells. Brain Res. 1999 May 15; 828(1-2):27-40. PMID: 10320722.
    Citations: 9     Fields:    Translation:AnimalsCells
  155. Coyle JT. Ice-nine and human prion disease. Harv Rev Psychiatry. 1999 Mar-Apr; 6(6):331-3. PMID: 10370441.
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