Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Denisa D. Wagner, Ph.D.

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Institution
Department
Address
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Mentoring
completed student projects
Platelet depletion accelerates thrombus resolution and decreases thrombus neovascularization in mice
Summer, 06/16/14 - 08/11/14

Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R35HL135765 (WAGNER, DENISA D) Jan 11, 2017 - Dec 31, 2023
    NIH
    How inflammation and thrombosis fuel disease and aging: Focus on NETs
    Role: Principal Investigator
  2. R01HL125501 (WAGNER, DENISA D) Dec 1, 2014 - Nov 30, 2018
    NIH
    NETs and their modulating enzymes in age-related inflammatory diseases
    Role: Principal Investigator
  3. R01HL102101 (WAGNER, DENISA D) Jun 15, 2011 - May 31, 2019
    NIH
    NETS in thrombosis and inflammatory responses
    Role: Principal Investigator
  4. R01HL095091 (WAKEFIELD, THOMAS WILLIAM) Sep 26, 2008 - Jul 31, 2013
    NIH
    Novel Therapeutic Targets for Venous Thromboembolism
    Role: Principal Investigator
  5. P01HL066105 (KRIEGER, MONTY) Dec 15, 2000 - Jun 30, 2013
    NIH/NHLBI
    Molecular Analysis of Cardiovascular Biology and Pathology
    Role: Co-Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Aymonnier K, Ng J, Fredenburgh LE, Zambrano-Vera K, Münzer P, Gutch S, Fukui S, Desjardins M, Subramaniam M, Baron RM, Raby BA, Perrella MA, Lederer JA, Wagner DD. Inflammasome activation in neutrophils of patients with severe COVID-19. Blood Adv. 2022 04 12; 6(7):2001-2013. PMID: 34991159.
    Citations:    Fields:    
  2. Fukui S, Gutch S, Fukui S, Cherpokova D, Aymonnier K, Sheehy CE, Chu L, Wagner DD. The prominent role of hematopoietic peptidyl arginine deiminase 4 in arthritis: collagen and G-CSF induced arthritis model in C57BL/6 mice. Arthritis Rheumatol. 2022 Feb 15. PMID: 35166055.
    Citations:    Fields:    
  3. Bowman TV, Jamieson C, Steidl U, Stanley ER, Gritsman K, Wagner D, Manwani D, Trumpp A, Suda T, Ito K, Dawlaty M, Lucas D, Pinho S. Paul S. Frenette (1965-2021). Cell Stem Cell. 2021 10 07; 28(10):1686-1689. PMID: 34624230.
    Citations:    Fields:    
  4. Bowman TV, Jamieson C, Steidl U, Stanley ER, Gritsman K, Wagner D, Manwani D, Trumpp A, Suda T, Ito K, Dawlaty M, Lucas D, Pinho S. Paul S. Frenette (1965-2021). Cell. 2021 Sep 30; 184(20):5073-5076. PMID: 34597597.
    Citations:    Fields:    
  5. Bowman TV, Jamieson C, Steidl U, Stanley ER, Gritsman K, Wagner D, Manwani D, Trumpp A, Suda T, Ito K, Dawlaty M, Lucas D, Pinho S. Paul S. Frenette (1965-2021). Dev Cell. 2021 Oct 11; 56(19):2688-2691. PMID: 34597594.
    Citations:    Fields:    
  6. Tilvawala R, Nemmara VV, Reyes AC, Sorvillo N, Salinger AJ, Cherpokova D, Fukui S, Gutch S, Wagner D, Thompson PR. The role of SERPIN citrullination in thrombosis. Cell Chem Biol. 2021 12 16; 28(12):1728-1739.e5. PMID: 34352225.
    Citations:    Fields:    Translation:Animals
  7. Münzer P, Negro R, Fukui S, di Meglio L, Aymonnier K, Chu L, Cherpokova D, Gutch S, Sorvillo N, Shi L, Magupalli VG, Weber ANR, Scharf RE, Waterman CM, Wu H, Wagner DD. NLRP3 Inflammasome Assembly in Neutrophils Is Supported by PAD4 and Promotes NETosis Under Sterile Conditions. Front Immunol. 2021; 12:683803. PMID: 34122445.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  8. Varjú I, Sorvillo N, Cherpokova D, Farkas ÁZ, Farkas VJ, Komorowicz E, Feller T, Kiss B, Kellermayer MZ, Szabó L, Wacha A, Bóta A, Longstaff C, Wagner DD, Kolev K. Citrullinated Fibrinogen Renders Clots Mechanically Less Stable, but Lysis-Resistant. Circ Res. 2021 07 09; 129(2):342-344. PMID: 34037437.
    Citations:    Fields:    Translation:HumansAnimalsCells
  9. Shi L, Aymonnier K, Wagner DD. Neutrophil stimulation with citrullinated histone H4 slows down calcium influx and reduces NET formation compared with native histone H4. PLoS One. 2021; 16(5):e0251726. PMID: 33999963.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  10. DeRoo E, Martinod K, Cherpokova D, Fuchs T, Cifuni S, Chu L, Staudinger C, Wagner DD. The role of platelets in thrombus fibrosis and vessel wall remodeling after venous thrombosis. J Thromb Haemost. 2021 02; 19(2):387-399. PMID: 33058430.
    Citations: 1     Fields:    Translation:AnimalsCells
  11. Thiam HR, Wong SL, Qiu R, Kittisopikul M, Vahabikashi A, Goldman AE, Goldman RD, Wagner DD, Waterman CM. Reply to Liu: The disassembly of the actin cytoskeleton is an early event during NETosis. Proc Natl Acad Sci U S A. 2020 09 15; 117(37):22655-22656. PMID: 32943583.
    Citations:    Fields:    Translation:Cells
  12. Thiam HR, Wong SL, Wagner DD, Waterman CM. Cellular Mechanisms of NETosis. Annu Rev Cell Dev Biol. 2020 10 06; 36:191-218. PMID: 32663035.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  13. Thiam HR, Wong SL, Qiu R, Kittisopikul M, Vahabikashi A, Goldman AE, Goldman RD, Wagner DD, Waterman CM. NETosis proceeds by cytoskeleton and endomembrane disassembly and PAD4-mediated chromatin decondensation and nuclear envelope rupture. Proc Natl Acad Sci U S A. 2020 03 31; 117(13):7326-7337. PMID: 32170015.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  14. Wong SL, Goverman J, Staudinger C, Wagner DD. Recombinant human ADAMTS13 treatment and anti-NET strategies enhance skin allograft survival in mice. Am J Transplant. 2020 04; 20(4):1162-1169. PMID: 31730284.
    Citations:    Fields:    Translation:HumansAnimals
  15. Cherpokova D, Jouvene CC, Libreros S, DeRoo EP, Chu L, de la Rosa X, Norris PC, Wagner DD, Serhan CN. Resolvin D4 attenuates the severity of pathological thrombosis in mice. Blood. 2019 10 24; 134(17):1458-1468. PMID: 31300403.
    Citations: 28     Fields:    Translation:Animals
  16. Sorvillo N, Cherpokova D, Martinod K, Wagner DD. Extracellular DNA NET-Works With Dire Consequences for Health. Circ Res. 2019 08 02; 125(4):470-488. PMID: 31518165.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  17. Sorvillo N, Mizurini DM, Coxon C, Martinod K, Tilvawala R, Cherpokova D, Salinger AJ, Seward RJ, Staudinger C, Weerapana E, Shapiro NI, Costello CE, Thompson PR, Wagner DD. Plasma Peptidylarginine Deiminase IV Promotes VWF-Platelet String Formation and Accelerates Thrombosis After Vessel Injury. Circ Res. 2019 08 16; 125(5):507-519. PMID: 31248335.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  18. Demers M, Suidan GL, Andrews N, Martinod K, Cabral JE, Wagner DD. Solid peripheral tumor leads to systemic inflammation, astrocyte activation and signs of behavioral despair in mice. PLoS One. 2018; 13(11):e0207241. PMID: 30439993.
    Citations: 3     Fields:    Translation:AnimalsCells
  19. Krishnamoorthy N, Douda DN, Brüggemann TR, Ricklefs I, Duvall MG, Abdulnour RE, Martinod K, Tavares L, Wang X, Cernadas M, Israel E, Mauger DT, Bleecker ER, Castro M, Erzurum SC, Gaston BM, Jarjour NN, Wenzel S, Dunican E, Fahy JV, Irimia D, Wagner DD, Levy BD. Neutrophil cytoplasts induce TH17 differentiation and skew inflammation toward neutrophilia in severe asthma. Sci Immunol. 2018 08 03; 3(26). PMID: 30076281.
    Citations: 56     Fields:    
  20. Wong SL, Wagner DD. Peptidylarginine deiminase 4: a nuclear button triggering neutrophil extracellular traps in inflammatory diseases and aging. FASEB J. 2018 Jun 20; fj201800691R. PMID: 29924943.
    Citations: 37     Fields:    
  21. Wolach O, Sellar RS, Martinod K, Cherpokova D, McConkey M, Chappell RJ, Silver AJ, Adams D, Castellano CA, Schneider RK, Padera RF, DeAngelo DJ, Wadleigh M, Steensma DP, Galinsky I, Stone RM, Genovese G, McCarroll SA, Iliadou B, Hultman C, Neuberg D, Mullally A, Wagner DD, Ebert BL. Increased neutrophil extracellular trap formation promotes thrombosis in myeloproliferative neoplasms. Sci Transl Med. 2018 04 11; 10(436). PMID: 29643232.
    Citations: 113     Fields:    Translation:AnimalsCells
  22. Franck G, Mawson TL, Folco EJ, Molinaro R, Ruvkun V, Engelbertsen D, Liu X, Tesmenitsky Y, Shvartz E, Sukhova GK, Michel JB, Nicoletti A, Lichtman A, Wagner D, Croce KJ, Libby P. Roles of PAD4 and NETosis in Experimental Atherosclerosis and Arterial Injury: Implications for Superficial Erosion. Circ Res. 2018 06 22; 123(1):33-42. PMID: 29572206.
    Citations: 67     Fields:    Translation:HumansAnimalsCells
  23. Mauracher LM, Posch F, Martinod K, Grilz E, Däullary T, Hell L, Brostjan C, Zielinski C, Ay C, Wagner DD, Pabinger I, Thaler J. Citrullinated histone H3, a biomarker of neutrophil extracellular trap formation, predicts the risk of venous thromboembolism in cancer patients. J Thromb Haemost. 2018 03; 16(3):508-518. PMID: 29325226.
    Citations: 73     Fields:    Translation:HumansCells
  24. Witsch T, Martinod K, Sorvillo N, Portier I, De Meyer SF, Wagner DD. Recombinant Human ADAMTS13 Treatment Improves Myocardial Remodeling and Functionality After Pressure Overload Injury in Mice. J Am Heart Assoc. 2018 01 24; 7(3). PMID: 29367415.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  25. Hayashi H, Cherpokova D, Martinod K, Witsch T, Wong SL, Gallant M, Cifuni SM, Guarente LP, Wagner DD. Sirt3 deficiency does not affect venous thrombosis or NETosis despite mild elevation of intracellular ROS in platelets and neutrophils in mice. PLoS One. 2017; 12(12):e0188341. PMID: 29236713.
    Citations: 5     Fields:    Translation:AnimalsCells
  26. Gavillet M, Martinod K, Renella R, Wagner DD, Williams DA. A key role for Rac and Pak signaling in neutrophil extracellular traps (NETs) formation defines a new potential therapeutic target. Am J Hematol. 2018 02; 93(2):269-276. PMID: 29124783.
    Citations: 16     Fields:    Translation:AnimalsCells
  27. Teague HL, Ahlman MA, Alavi A, Wagner DD, Lichtman AH, Nahrendorf M, Swirski FK, Nestle F, Gelfand JM, Kaplan MJ, Grinspoon S, Ridker PM, Newby DE, Tawakol A, Fayad ZA, Mehta NN. Unraveling Vascular Inflammation: From Immunology to Imaging. J Am Coll Cardiol. 2017 Sep 12; 70(11):1403-1412. PMID: 28882238.
    Citations: 19     Fields:    Translation:Humans
  28. Ponomaryov T, Payne H, Fabritz L, Wagner DD, Brill A. Mast Cells Granular Contents Are Crucial for Deep Vein Thrombosis in Mice. Circ Res. 2017 Sep 29; 121(8):941-950. PMID: 28739590.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  29. Zitomersky NL, Demers M, Martinod K, Gallant M, Cifuni SM, Biswas A, Snapper S, Wagner DD. ADAMTS13 Deficiency Worsens Colitis and Exogenous ADAMTS13 Administration Decreases Colitis Severity in Mice. TH Open. 2017 Jun; 1(1):e11-e23. PMID: 29376146.
    Citations: 5     
  30. Martinod K, Witsch T, Erpenbeck L, Savchenko A, Hayashi H, Cherpokova D, Gallant M, Mauler M, Cifuni SM, Wagner DD. Peptidylarginine deiminase 4 promotes age-related organ fibrosis. J Exp Med. 2017 02; 214(2):439-458. PMID: 28031479.
    Citations: 56     Fields:    Translation:AnimalsCells
  31. Erpenbeck L, Chowdhury CS, Zsengellér ZK, Gallant M, Burke SD, Cifuni S, Hahn S, Wagner DD, Karumanchi SA. PAD4 Deficiency Decreases Inflammation and Susceptibility to Pregnancy Loss in a Mouse Model. Biol Reprod. 2016 12; 95(6):132. PMID: 28007693.
    Citations: 9     Fields:    Translation:AnimalsCells
  32. Shaw MA, Kombrinck KW, McElhinney KE, Sweet DR, Flick MJ, Palumbo JS, Cheng M, Esmon NL, Esmon CT, Brill A, Wagner DD, Degen JL, Mullins ES. Limiting prothrombin activation to meizothrombin is compatible with survival but significantly alters hemostasis in mice. Blood. 2016 08 04; 128(5):721-31. PMID: 27252233.
    Citations: 5     Fields:    Translation:Animals
  33. Pillai PS, Molony RD, Martinod K, Dong H, Pang IK, Tal MC, Solis AG, Bielecki P, Mohanty S, Trentalange M, Homer RJ, Flavell RA, Wagner DD, Montgomery RR, Shaw AC, Staeheli P, Iwasaki A. Mx1 reveals innate pathways to antiviral resistance and lethal influenza disease. Science. 2016 Apr 22; 352(6284):463-6. PMID: 27102485.
    Citations: 113     Fields:    Translation:HumansAnimalsCells
  34. Demers M, Wong SL, Martinod K, Gallant M, Cabral JE, Wang Y, Wagner DD. Priming of neutrophils toward NETosis promotes tumor growth. Oncoimmunology. 2016 May; 5(5):e1134073. PMID: 27467952.
    Citations: 78     Fields:    
  35. Thålin C, Demers M, Blomgren B, Wong SL, von Arbin M, von Heijne A, Laska AC, Wallén H, Wagner DD, Aspberg S. NETosis promotes cancer-associated arterial microthrombosis presenting as ischemic stroke with troponin elevation. Thromb Res. 2016 Mar; 139:56-64. PMID: 26916297.
    Citations: 63     Fields:    Translation:HumansCells
  36. Gavillet M, Martinod K, Renella R, Harris C, Shapiro NI, Wagner DD, Williams DA. Flow cytometric assay for direct quantification of neutrophil extracellular traps in blood samples. Am J Hematol. 2015 Dec; 90(12):1155-8. PMID: 26347989.
    Citations: 47     Fields:    Translation:HumansAnimalsCells
  37. Wong SL, Demers M, Martinod K, Gallant M, Wang Y, Goldfine AB, Kahn CR, Wagner DD. Diabetes primes neutrophils to undergo NETosis, which impairs wound healing. Nat Med. 2015 Jul; 21(7):815-9. PMID: 26076037.
    Citations: 313     Fields:    Translation:HumansAnimalsCells
  38. Erpenbeck L, Demers M, Zsengellér ZK, Gallant M, Cifuni SM, Stillman IE, Karumanchi SA, Wagner DD. ADAMTS13 Endopeptidase Protects against Vascular Endothelial Growth Factor Inhibitor-Induced Thrombotic Microangiopathy. J Am Soc Nephrol. 2016 Jan; 27(1):120-31. PMID: 26038528.
    Citations: 6     Fields:    Translation:Animals
  39. Etulain J, Martinod K, Wong SL, Cifuni SM, Schattner M, Wagner DD. P-selectin promotes neutrophil extracellular trap formation in mice. Blood. 2015 Jul 09; 126(2):242-6. PMID: 25979951.
    Citations: 133     Fields:    Translation:AnimalsCells
  40. Martinod K, Fuchs TA, Zitomersky NL, Wong SL, Demers M, Gallant M, Wang Y, Wagner DD. PAD4-deficiency does not affect bacteremia in polymicrobial sepsis and ameliorates endotoxemic shock. Blood. 2015 Mar 19; 125(12):1948-56. PMID: 25624317.
    Citations: 80     Fields:    Translation:AnimalsCells
  41. Lewis HD, Liddle J, Coote JE, Atkinson SJ, Barker MD, Bax BD, Bicker KL, Bingham RP, Campbell M, Chen YH, Chung CW, Craggs PD, Davis RP, Eberhard D, Joberty G, Lind KE, Locke K, Maller C, Martinod K, Patten C, Polyakova O, Rise CE, Rüdiger M, Sheppard RJ, Slade DJ, Thomas P, Thorpe J, Yao G, Drewes G, Wagner DD, Thompson PR, Prinjha RK, Wilson DM. Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation. Nat Chem Biol. 2015 Mar; 11(3):189-91. PMID: 25622091.
    Citations: 201     Fields:    Translation:HumansAnimalsCells
  42. Reiner MF, Martinod K, Stivala S, Savarese G, Camici GG, Lüscher TF, Wagner DD, Beer JH. Dietary omega-3 alpha-linolenic acid does not prevent venous thrombosis in mice. Thromb Haemost. 2015 Jan; 113(1):177-84. PMID: 25231375.
    Citations: 4     Fields:    Translation:Animals
  43. Chen G, Zhang D, Fuchs TA, Manwani D, Wagner DD, Frenette PS. Heme-induced neutrophil extracellular traps contribute to the pathogenesis of sickle cell disease. Blood. 2014 Jun 12; 123(24):3818-27. PMID: 24620350.
    Citations: 128     Fields:    Translation:HumansAnimalsCells
  44. Demers M, Wagner DD. NETosis: a new factor in tumor progression and cancer-associated thrombosis. Semin Thromb Hemost. 2014 Apr; 40(3):277-83. PMID: 24590420.
    Citations: 71     Fields:    Translation:HumansAnimalsCells
  45. Martinod K, Wagner DD. Thrombosis: tangled up in NETs. Blood. 2014 May 01; 123(18):2768-76. PMID: 24366358.
    Citations: 254     Fields:    Translation:HumansAnimalsCells
  46. Savchenko AS, Borissoff JI, Martinod K, De Meyer SF, Gallant M, Erpenbeck L, Brill A, Wang Y, Wagner DD. VWF-mediated leukocyte recruitment with chromatin decondensation by PAD4 increases myocardial ischemia/reperfusion injury in mice. Blood. 2014 Jan 02; 123(1):141-8. PMID: 24200682.
    Citations: 112     Fields:    Translation:HumansAnimalsCells
  47. Suidan GL, Brill A, De Meyer SF, Voorhees JR, Cifuni SM, Cabral JE, Wagner DD. Endothelial Von Willebrand factor promotes blood-brain barrier flexibility and provides protection from hypoxia and seizures in mice. Arterioscler Thromb Vasc Biol. 2013 Sep; 33(9):2112-20. PMID: 23825365.
    Citations: 33     Fields:    Translation:AnimalsCells
  48. Borissoff JI, Joosen IA, Versteylen MO, Brill A, Fuchs TA, Savchenko AS, Gallant M, Martinod K, Ten Cate H, Hofstra L, Crijns HJ, Wagner DD, Kietselaer BLJH. Elevated levels of circulating DNA and chromatin are independently associated with severe coronary atherosclerosis and a prothrombotic state. Arterioscler Thromb Vasc Biol. 2013 Aug; 33(8):2032-2040. PMID: 23818485.
    Citations: 140     Fields:    Translation:HumansCells
  49. Martinod K, Demers M, Fuchs TA, Wong SL, Brill A, Gallant M, Hu J, Wang Y, Wagner DD. Neutrophil histone modification by peptidylarginine deiminase 4 is critical for deep vein thrombosis in mice. Proc Natl Acad Sci U S A. 2013 May 21; 110(21):8674-9. PMID: 23650392.
    Citations: 215     Fields:    Translation:AnimalsCells
  50. Fuchs TA, Alvarez JJ, Martinod K, Bhandari AA, Kaufman RM, Wagner DD. Neutrophils release extracellular DNA traps during storage of red blood cell units. Transfusion. 2013 Dec; 53(12):3210-6. PMID: 23560771.
    Citations: 14     Fields:    Translation:HumansCells
  51. Suidan GL, Duerschmied D, Dillon GM, Vanderhorst V, Hampton TG, Wong SL, Voorhees JR, Wagner DD. Lack of tryptophan hydroxylase-1 in mice results in gait abnormalities. PLoS One. 2013; 8(3):e59032. PMID: 23516593.
    Citations: 8     Fields:    Translation:Animals
  52. Demers M, Wagner DD. Neutrophil extracellular traps: A new link to cancer-associated thrombosis and potential implications for tumor progression. Oncoimmunology. 2013 Feb 01; 2(2):e22946. PMID: 23526174.
    Citations: 73     Fields:    
  53. Duerschmied D, Suidan GL, Demers M, Herr N, Carbo C, Brill A, Cifuni SM, Mauler M, Cicko S, Bader M, Idzko M, Bode C, Wagner DD. Platelet serotonin promotes the recruitment of neutrophils to sites of acute inflammation in mice. Blood. 2013 Feb 07; 121(6):1008-15. PMID: 23243271.
    Citations: 98     Fields:    Translation:AnimalsCells
  54. Carbo C, Yuki K, Demers M, Wagner DD, Shimaoka M. Isoflurane inhibits neutrophil recruitment in the cutaneous Arthus reaction model. J Anesth. 2013 Apr; 27(2):261-8. PMID: 23096126.
    Citations: 22     Fields:    Translation:Animals
  55. Chen K, Nishi H, Travers R, Tsuboi N, Martinod K, Wagner DD, Stan R, Croce K, Mayadas TN. Endocytosis of soluble immune complexes leads to their clearance by Fc?RIIIB but induces neutrophil extracellular traps via Fc?RIIA in vivo. Blood. 2012 Nov 22; 120(22):4421-31. PMID: 22955924.
    Citations: 80     Fields:    Translation:HumansAnimalsCells
  56. De Meyer SF, Savchenko AS, Haas MS, Schatzberg D, Carroll MC, Schiviz A, Dietrich B, Rottensteiner H, Scheiflinger F, Wagner DD. Protective anti-inflammatory effect of ADAMTS13 on myocardial ischemia/reperfusion injury in mice. Blood. 2012 Dec 20; 120(26):5217-23. PMID: 22915644.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  57. Demers M, Krause DS, Schatzberg D, Martinod K, Voorhees JR, Fuchs TA, Scadden DT, Wagner DD. Cancers predispose neutrophils to release extracellular DNA traps that contribute to cancer-associated thrombosis. Proc Natl Acad Sci U S A. 2012 Aug 07; 109(32):13076-81. PMID: 22826226.
    Citations: 316     Fields:    Translation:AnimalsCells
  58. Crescente M, Thomas GM, Demers M, Voorhees JR, Wong SL, Ho-Tin-Noé B, Wagner DD. ADAMTS13 exerts a thrombolytic effect in microcirculation. Thromb Haemost. 2012 Sep; 108(3):527-32. PMID: 22782575.
    Citations: 12     Fields:    Translation:HumansAnimals
  59. Korin N, Kanapathipillai M, Matthews BD, Crescente M, Brill A, Mammoto T, Ghosh K, Jurek S, Bencherif SA, Bhatta D, Coskun AU, Feldman CL, Wagner DD, Ingber DE. Shear-activated nanotherapeutics for drug targeting to obstructed blood vessels. Science. 2012 Aug 10; 337(6095):738-42. PMID: 22767894.
    Citations: 114     Fields:    Translation:Animals
  60. Fuchs TA, Brill A, Wagner DD. Neutrophil extracellular trap (NET) impact on deep vein thrombosis. Arterioscler Thromb Vasc Biol. 2012 Aug; 32(8):1777-83. PMID: 22652600.
    Citations: 174     Fields:    Translation:HumansAnimalsCells
  61. Brill A, Yesilaltay A, De Meyer SF, Kisucka J, Fuchs TA, Kocher O, Krieger M, Wagner DD. Extrahepatic high-density lipoprotein receptor SR-BI and apoA-I protect against deep vein thrombosis in mice. Arterioscler Thromb Vasc Biol. 2012 Aug; 32(8):1841-7. PMID: 22652597.
    Citations: 21     Fields:    Translation:AnimalsCells
  62. De Meyer SF, Suidan GL, Fuchs TA, Monestier M, Wagner DD. Extracellular chromatin is an important mediator of ischemic stroke in mice. Arterioscler Thromb Vasc Biol. 2012 Aug; 32(8):1884-91. PMID: 22628431.
    Citations: 81     Fields:    Translation:AnimalsCells
  63. Fuchs TA, Kremer Hovinga JA, Schatzberg D, Wagner DD, Lämmle B. Circulating DNA and myeloperoxidase indicate disease activity in patients with thrombotic microangiopathies. Blood. 2012 Aug 09; 120(6):1157-64. PMID: 22611154.
    Citations: 91     Fields:    Translation:HumansCells
  64. Thomas GM, Carbo C, Curtis BR, Martinod K, Mazo IB, Schatzberg D, Cifuni SM, Fuchs TA, von Andrian UH, Hartwig JH, Aster RH, Wagner DD. Extracellular DNA traps are associated with the pathogenesis of TRALI in humans and mice. Blood. 2012 Jun 28; 119(26):6335-43. PMID: 22596262.
    Citations: 109     Fields:    Translation:HumansAnimalsCells
  65. von Brühl ML, Stark K, Steinhart A, Chandraratne S, Konrad I, Lorenz M, Khandoga A, Tirniceriu A, Coletti R, Köllnberger M, Byrne RA, Laitinen I, Walch A, Brill A, Pfeiler S, Manukyan D, Braun S, Lange P, Riegger J, Ware J, Eckart A, Haidari S, Rudelius M, Schulz C, Echtler K, Brinkmann V, Schwaiger M, Preissner KT, Wagner DD, Mackman N, Engelmann B, Massberg S. Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo. J Exp Med. 2012 Apr 09; 209(4):819-35. PMID: 22451716.
    Citations: 539     Fields:    Translation:AnimalsCells
  66. Siller-Matula JM, Merhi Y, Tanguay JF, Duerschmied D, Wagner DD, McGinness KE, Pendergrast PS, Chung JK, Tian X, Schaub RG, Jilma B. ARC15105 is a potent antagonist of von Willebrand factor mediated platelet activation and adhesion. Arterioscler Thromb Vasc Biol. 2012 Apr; 32(4):902-9. PMID: 22282355.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  67. Brill A, Fuchs TA, Savchenko AS, Thomas GM, Martinod K, De Meyer SF, Bhandari AA, Wagner DD. Neutrophil extracellular traps promote deep vein thrombosis in mice. J Thromb Haemost. 2012 Jan; 10(1):136-44. PMID: 22044575.
    Citations: 320     Fields:    Translation:AnimalsCells
  68. Demers M, Wagner DD. Targeting platelet function to improve drug delivery. Oncoimmunology. 2012 Jan 01; 1(1):100-102. PMID: 22720224.
    Citations: 10     Fields:    
  69. De Meyer SF, Stoll G, Wagner DD, Kleinschnitz C. von Willebrand factor: an emerging target in stroke therapy. Stroke. 2012 Feb; 43(2):599-606. PMID: 22180250.
    Citations: 66     Fields:    Translation:HumansCells
  70. Jansen AJ, Josefsson EC, Rumjantseva V, Liu QP, Falet H, Bergmeier W, Cifuni SM, Sackstein R, von Andrian UH, Wagner DD, Hartwig JH, Hoffmeister KM. Desialylation accelerates platelet clearance after refrigeration and initiates GPIba metalloproteinase-mediated cleavage in mice. Blood. 2012 Feb 02; 119(5):1263-73. PMID: 22101895.
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