Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Denisa D. Wagner, Ph.D.

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Mentoring
completed student projects
Platelet depletion accelerates thrombus resolution and decreases thrombus neovascularization in mice
Summer, 06/16/14 - 08/11/14

Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R35HL135765 (WAGNER, DENISA D) Jan 11, 2017 - Dec 31, 2023
    NIH/NHLBI
    How inflammation and thrombosis fuel disease and aging: Focus on NETs
    Role: Principal Investigator
  2. R01HL125501 (WAGNER, DENISA D) Dec 1, 2014 - Nov 30, 2018
    NIH/NHLBI
    NETs and their modulating enzymes in age-related inflammatory diseases
    Role: Principal Investigator
  3. R01HL102101 (WAGNER, DENISA D) Apr 1, 2010 - Sep 30, 2012
    NIH/NHLBI
    NETS in thrombosis and inflammatory responses
    Role: Principal Investigator
  4. R01HL095091 (WAKEFIELD, THOMAS WILLIAM) Sep 26, 2008 - Jul 31, 2013
    NIH/NHLBI
    Novel Therapeutic Targets for Venous Thromboembolism
    Role: Principal Investigator
  5. P01HL066105 (KRIEGER, MONTY) Dec 15, 2000 - Jun 30, 2013
    NIH/NHLBI
    Molecular Analysis of Cardiovascular Biology and Pathology
    Role: Co-Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Thiam HR, Wong SL, Qiu R, Kittisopikul M, Vahabikashi A, Goldman AE, Goldman RD, Wagner DD, Waterman CM. Reply to Liu: The disassembly of the actin cytoskeleton is an early event during NETosis. Proc Natl Acad Sci U S A. 2020 Sep 15; 117(37):22655-22656. PMID: 32943583.
    Citations:    
  2. Thiam HR, Wong SL, Wagner DD, Waterman CM. Cellular Mechanisms of NETosis. Annu Rev Cell Dev Biol. 2020 Jul 14. PMID: 32663035.
    Citations:    
  3. Thiam HR, Wong SL, Qiu R, Kittisopikul M, Vahabikashi A, Goldman AE, Goldman RD, Wagner DD, Waterman CM. NETosis proceeds by cytoskeleton and endomembrane disassembly and PAD4-mediated chromatin decondensation and nuclear envelope rupture. Proc Natl Acad Sci U S A. 2020 03 31; 117(13):7326-7337. PMID: 32170015.
    Citations:    
  4. Wong SL, Goverman J, Staudinger C, Wagner DD. Recombinant human ADAMTS13 treatment and anti-NET strategies enhance skin allograft survival in mice. Am J Transplant. 2020 04; 20(4):1162-1169. PMID: 31730284.
    Citations:    
  5. Cherpokova D, Jouvene CC, Libreros S, DeRoo EP, Chu L, de la Rosa X, Norris PC, Wagner DD, Serhan CN. Resolvin D4 attenuates the severity of pathological thrombosis in mice. Blood. 2019 10 24; 134(17):1458-1468. PMID: 31300403.
    Citations:    
  6. Sorvillo N, Cherpokova D, Martinod K, Wagner DD. Extracellular DNA NET-Works With Dire Consequences for Health. Circ Res. 2019 08 02; 125(4):470-488. PMID: 31518165.
    Citations:    
  7. Sorvillo N, Mizurini DM, Coxon C, Martinod K, Tilvawala R, Cherpokova D, Salinger AJ, Seward RJ, Staudinger C, Weerapana E, Shapiro NI, Costello CE, Thompson PR, Wagner DD. Plasma Peptidylarginine Deiminase IV Promotes VWF-Platelet String Formation and Accelerates Thrombosis After Vessel Injury. Circ Res. 2019 08 16; 125(5):507-519. PMID: 31248335.
    Citations:    
  8. Demers M, Suidan GL, Andrews N, Martinod K, Cabral JE, Wagner DD. Solid peripheral tumor leads to systemic inflammation, astrocyte activation and signs of behavioral despair in mice. PLoS One. 2018; 13(11):e0207241. PMID: 30439993.
    Citations:    Fields:    
  9. Krishnamoorthy N, Douda DN, Brüggemann TR, Ricklefs I, Duvall MG, Abdulnour RE, Martinod K, Tavares L, Wang X, Cernadas M, Israel E, Mauger DT, Bleecker ER, Castro M, Erzurum SC, Gaston BM, Jarjour NN, Wenzel S, Dunican E, Fahy JV, Irimia D, Wagner DD, Levy BD. Neutrophil cytoplasts induce TH17 differentiation and skew inflammation toward neutrophilia in severe asthma. Sci Immunol. 2018 08 03; 3(26). PMID: 30076281.
    Citations:    Fields:    
  10. Wong SL, Wagner DD. Peptidylarginine deiminase 4: a nuclear button triggering neutrophil extracellular traps in inflammatory diseases and aging. FASEB J. 2018 Jun 20; fj201800691R. PMID: 29924943.
    Citations:    Fields:    
  11. Wolach O, Sellar RS, Martinod K, Cherpokova D, McConkey M, Chappell RJ, Silver AJ, Adams D, Castellano CA, Schneider RK, Padera RF, DeAngelo DJ, Wadleigh M, Steensma DP, Galinsky I, Stone RM, Genovese G, McCarroll SA, Iliadou B, Hultman C, Neuberg D, Mullally A, Wagner DD, Ebert BL. Increased neutrophil extracellular trap formation promotes thrombosis in myeloproliferative neoplasms. Sci Transl Med. 2018 04 11; 10(436). PMID: 29643232.
    Citations: 4     Fields:    
  12. Franck G, Mawson TL, Folco EJ, Molinaro R, Ruvkun V, Engelbertsen D, Liu X, Tesmenitsky Y, Shvartz E, Sukhova GK, Michel JB, Nicoletti A, Lichtman A, Wagner D, Croce KJ, Libby P. Roles of PAD4 and NETosis in Experimental Atherosclerosis and Arterial Injury: Implications for Superficial Erosion. Circ Res. 2018 06 22; 123(1):33-42. PMID: 29572206.
    Citations: 2     Fields:    
  13. Mauracher LM, Posch F, Martinod K, Grilz E, Däullary T, Hell L, Brostjan C, Zielinski C, Ay C, Wagner DD, Pabinger I, Thaler J. Citrullinated histone H3, a biomarker of neutrophil extracellular trap formation, predicts the risk of venous thromboembolism in cancer patients. J Thromb Haemost. 2018 03; 16(3):508-518. PMID: 29325226.
    Citations:    
  14. Witsch T, Martinod K, Sorvillo N, Portier I, De Meyer SF, Wagner DD. Recombinant Human ADAMTS13 Treatment Improves Myocardial Remodeling and Functionality After Pressure Overload Injury in Mice. J Am Heart Assoc. 2018 01 24; 7(3). PMID: 29367415.
    Citations: 2     Fields:    
  15. Hayashi H, Cherpokova D, Martinod K, Witsch T, Wong SL, Gallant M, Cifuni SM, Guarente LP, Wagner DD. Sirt3 deficiency does not affect venous thrombosis or NETosis despite mild elevation of intracellular ROS in platelets and neutrophils in mice. PLoS One. 2017; 12(12):e0188341. PMID: 29236713.
    Citations:    Fields:    Translation:AnimalsCells
  16. Gavillet M, Martinod K, Renella R, Wagner DD, Williams DA. A key role for Rac and Pak signaling in neutrophil extracellular traps (NETs) formation defines a new potential therapeutic target. Am J Hematol. 2018 02; 93(2):269-276. PMID: 29124783.
    Citations: 2     Fields:    Translation:AnimalsCells
  17. Teague HL, Ahlman MA, Alavi A, Wagner DD, Lichtman AH, Nahrendorf M, Swirski FK, Nestle F, Gelfand JM, Kaplan MJ, Grinspoon S, Ridker PM, Newby DE, Tawakol A, Fayad ZA, Mehta NN. Unraveling Vascular Inflammation: From Immunology to Imaging. J Am Coll Cardiol. 2017 Sep 12; 70(11):1403-1412. PMID: 28882238.
    Citations: 4     Fields:    Translation:Humans
  18. Ponomaryov T, Payne H, Fabritz L, Wagner DD, Brill A. Mast Cells Granular Contents Are Crucial for Deep Vein Thrombosis in Mice. Circ Res. 2017 Sep 29; 121(8):941-950. PMID: 28739590.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  19. Zitomersky NL, Demers M, Martinod K, Gallant M, Cifuni SM, Biswas A, Snapper S, Wagner DD. ADAMTS13 Deficiency Worsens Colitis and Exogenous ADAMTS13 Administration Decreases Colitis Severity in Mice. TH Open. 2017 Jun; 1(1):e11-e23. PMID: 29376146.
    Citations:    
  20. Martinod K, Witsch T, Erpenbeck L, Savchenko A, Hayashi H, Cherpokova D, Gallant M, Mauler M, Cifuni SM, Wagner DD. Peptidylarginine deiminase 4 promotes age-related organ fibrosis. J Exp Med. 2017 02; 214(2):439-458. PMID: 28031479.
    Citations: 9     Fields:    Translation:AnimalsCells
  21. Erpenbeck L, Chowdhury CS, Zsengellér ZK, Gallant M, Burke SD, Cifuni S, Hahn S, Wagner DD, Karumanchi SA. PAD4 Deficiency Decreases Inflammation and Susceptibility to Pregnancy Loss in a Mouse Model. Biol Reprod. 2016 12; 95(6):132. PMID: 28007693.
    Citations: 2     Fields:    Translation:AnimalsCells
  22. Shaw MA, Kombrinck KW, McElhinney KE, Sweet DR, Flick MJ, Palumbo JS, Cheng M, Esmon NL, Esmon CT, Brill A, Wagner DD, Degen JL, Mullins ES. Limiting prothrombin activation to meizothrombin is compatible with survival but significantly alters hemostasis in mice. Blood. 2016 08 04; 128(5):721-31. PMID: 27252233.
    Citations: 2     Fields:    Translation:Animals
  23. Pillai PS, Molony RD, Martinod K, Dong H, Pang IK, Tal MC, Solis AG, Bielecki P, Mohanty S, Trentalange M, Homer RJ, Flavell RA, Wagner DD, Montgomery RR, Shaw AC, Staeheli P, Iwasaki A. Mx1 reveals innate pathways to antiviral resistance and lethal influenza disease. Science. 2016 Apr 22; 352(6284):463-6. PMID: 27102485.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  24. Demers M, Wong SL, Martinod K, Gallant M, Cabral JE, Wang Y, Wagner DD. Priming of neutrophils toward NETosis promotes tumor growth. Oncoimmunology. 2016 May; 5(5):e1134073. PMID: 27467952.
    Citations: 16     
  25. Thålin C, Demers M, Blomgren B, Wong SL, von Arbin M, von Heijne A, Laska AC, Wallén H, Wagner DD, Aspberg S. NETosis promotes cancer-associated arterial microthrombosis presenting as ischemic stroke with troponin elevation. Thromb Res. 2016 Mar; 139:56-64. PMID: 26916297.
    Citations: 12     Fields:    Translation:HumansCells
  26. Gavillet M, Martinod K, Renella R, Harris C, Shapiro NI, Wagner DD, Williams DA. Flow cytometric assay for direct quantification of neutrophil extracellular traps in blood samples. Am J Hematol. 2015 Dec; 90(12):1155-8. PMID: 26347989.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  27. Wong SL, Demers M, Martinod K, Gallant M, Wang Y, Goldfine AB, Kahn CR, Wagner DD. Diabetes primes neutrophils to undergo NETosis, which impairs wound healing. Nat Med. 2015 Jul; 21(7):815-9. PMID: 26076037.
    Citations: 90     Fields:    Translation:HumansAnimalsCells
  28. Erpenbeck L, Demers M, Zsengellér ZK, Gallant M, Cifuni SM, Stillman IE, Karumanchi SA, Wagner DD. ADAMTS13 Endopeptidase Protects against Vascular Endothelial Growth Factor Inhibitor-Induced Thrombotic Microangiopathy. J Am Soc Nephrol. 2016 Jan; 27(1):120-31. PMID: 26038528.
    Citations: 5     Fields:    Translation:Animals
  29. Etulain J, Martinod K, Wong SL, Cifuni SM, Schattner M, Wagner DD. P-selectin promotes neutrophil extracellular trap formation in mice. Blood. 2015 Jul 09; 126(2):242-6. PMID: 25979951.
    Citations: 36     Fields:    Translation:AnimalsCells
  30. Martinod K, Fuchs TA, Zitomersky NL, Wong SL, Demers M, Gallant M, Wang Y, Wagner DD. PAD4-deficiency does not affect bacteremia in polymicrobial sepsis and ameliorates endotoxemic shock. Blood. 2015 Mar 19; 125(12):1948-56. PMID: 25624317.
    Citations: 30     Fields:    Translation:AnimalsCells
  31. Lewis HD, Liddle J, Coote JE, Atkinson SJ, Barker MD, Bax BD, Bicker KL, Bingham RP, Campbell M, Chen YH, Chung CW, Craggs PD, Davis RP, Eberhard D, Joberty G, Lind KE, Locke K, Maller C, Martinod K, Patten C, Polyakova O, Rise CE, Rüdiger M, Sheppard RJ, Slade DJ, Thomas P, Thorpe J, Yao G, Drewes G, Wagner DD, Thompson PR, Prinjha RK, Wilson DM. Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation. Nat Chem Biol. 2015 Mar; 11(3):189-91. PMID: 25622091.
    Citations: 58     Fields:    Translation:HumansAnimalsCells
  32. Reiner MF, Martinod K, Stivala S, Savarese G, Camici GG, Lüscher TF, Wagner DD, Beer JH. Dietary omega-3 alpha-linolenic acid does not prevent venous thrombosis in mice. Thromb Haemost. 2015 Jan; 113(1):177-84. PMID: 25231375.
    Citations:    Fields:    Translation:Animals
  33. Chen G, Zhang D, Fuchs TA, Manwani D, Wagner DD, Frenette PS. Heme-induced neutrophil extracellular traps contribute to the pathogenesis of sickle cell disease. Blood. 2014 Jun 12; 123(24):3818-27. PMID: 24620350.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  34. Demers M, Wagner DD. NETosis: a new factor in tumor progression and cancer-associated thrombosis. Semin Thromb Hemost. 2014 Apr; 40(3):277-83. PMID: 24590420.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  35. Martinod K, Wagner DD. Thrombosis: tangled up in NETs. Blood. 2014 May 01; 123(18):2768-76. PMID: 24366358.
    Citations: 86     Fields:    Translation:HumansAnimalsCells
  36. Savchenko AS, Borissoff JI, Martinod K, De Meyer SF, Gallant M, Erpenbeck L, Brill A, Wang Y, Wagner DD. VWF-mediated leukocyte recruitment with chromatin decondensation by PAD4 increases myocardial ischemia/reperfusion injury in mice. Blood. 2014 Jan 02; 123(1):141-8. PMID: 24200682.
    Citations: 47     Fields:    Translation:HumansAnimalsCells
  37. Suidan GL, Brill A, De Meyer SF, Voorhees JR, Cifuni SM, Cabral JE, Wagner DD. Endothelial Von Willebrand factor promotes blood-brain barrier flexibility and provides protection from hypoxia and seizures in mice. Arterioscler Thromb Vasc Biol. 2013 Sep; 33(9):2112-20. PMID: 23825365.
    Citations: 14     Fields:    Translation:AnimalsCells
  38. Borissoff JI, Joosen IA, Versteylen MO, Brill A, Fuchs TA, Savchenko AS, Gallant M, Martinod K, Ten Cate H, Hofstra L, Crijns HJ, Wagner DD, Kietselaer BLJH. Elevated levels of circulating DNA and chromatin are independently associated with severe coronary atherosclerosis and a prothrombotic state. Arterioscler Thromb Vasc Biol. 2013 Aug; 33(8):2032-2040. PMID: 23818485.
    Citations: 50     Fields:    Translation:HumansCells
  39. Martinod K, Demers M, Fuchs TA, Wong SL, Brill A, Gallant M, Hu J, Wang Y, Wagner DD. Neutrophil histone modification by peptidylarginine deiminase 4 is critical for deep vein thrombosis in mice. Proc Natl Acad Sci U S A. 2013 May 21; 110(21):8674-9. PMID: 23650392.
    Citations: 86     Fields:    Translation:AnimalsCells
  40. Fuchs TA, Alvarez JJ, Martinod K, Bhandari AA, Kaufman RM, Wagner DD. Neutrophils release extracellular DNA traps during storage of red blood cell units. Transfusion. 2013 Dec; 53(12):3210-6. PMID: 23560771.
    Citations: 10     Fields:    Translation:HumansCells
  41. Suidan GL, Duerschmied D, Dillon GM, Vanderhorst V, Hampton TG, Wong SL, Voorhees JR, Wagner DD. Lack of tryptophan hydroxylase-1 in mice results in gait abnormalities. PLoS One. 2013; 8(3):e59032. PMID: 23516593.
    Citations: 5     Fields:    Translation:Animals
  42. Demers M, Wagner DD. Neutrophil extracellular traps: A new link to cancer-associated thrombosis and potential implications for tumor progression. Oncoimmunology. 2013 Feb 01; 2(2):e22946. PMID: 23526174.
    Citations: 34     
  43. Duerschmied D, Suidan GL, Demers M, Herr N, Carbo C, Brill A, Cifuni SM, Mauler M, Cicko S, Bader M, Idzko M, Bode C, Wagner DD. Platelet serotonin promotes the recruitment of neutrophils to sites of acute inflammation in mice. Blood. 2013 Feb 07; 121(6):1008-15. PMID: 23243271.
    Citations: 43     Fields:    Translation:AnimalsCells
  44. Carbo C, Yuki K, Demers M, Wagner DD, Shimaoka M. Isoflurane inhibits neutrophil recruitment in the cutaneous Arthus reaction model. J Anesth. 2013 Apr; 27(2):261-8. PMID: 23096126.
    Citations: 11     Fields:    Translation:Animals
  45. Chen K, Nishi H, Travers R, Tsuboi N, Martinod K, Wagner DD, Stan R, Croce K, Mayadas TN. Endocytosis of soluble immune complexes leads to their clearance by Fc?RIIIB but induces neutrophil extracellular traps via Fc?RIIA in vivo. Blood. 2012 Nov 22; 120(22):4421-31. PMID: 22955924.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  46. De Meyer SF, Savchenko AS, Haas MS, Schatzberg D, Carroll MC, Schiviz A, Dietrich B, Rottensteiner H, Scheiflinger F, Wagner DD. Protective anti-inflammatory effect of ADAMTS13 on myocardial ischemia/reperfusion injury in mice. Blood. 2012 Dec 20; 120(26):5217-23. PMID: 22915644.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  47. Demers M, Krause DS, Schatzberg D, Martinod K, Voorhees JR, Fuchs TA, Scadden DT, Wagner DD. Cancers predispose neutrophils to release extracellular DNA traps that contribute to cancer-associated thrombosis. Proc Natl Acad Sci U S A. 2012 Aug 07; 109(32):13076-81. PMID: 22826226.
    Citations: 137     Fields:    Translation:AnimalsCells
  48. Crescente M, Thomas GM, Demers M, Voorhees JR, Wong SL, Ho-Tin-Noé B, Wagner DD. ADAMTS13 exerts a thrombolytic effect in microcirculation. Thromb Haemost. 2012 Sep; 108(3):527-32. PMID: 22782575.
    Citations: 4     Fields:    Translation:HumansAnimals
  49. Korin N, Kanapathipillai M, Matthews BD, Crescente M, Brill A, Mammoto T, Ghosh K, Jurek S, Bencherif SA, Bhatta D, Coskun AU, Feldman CL, Wagner DD, Ingber DE. Shear-activated nanotherapeutics for drug targeting to obstructed blood vessels. Science. 2012 Aug 10; 337(6095):738-42. PMID: 22767894.
    Citations: 53     Fields:    Translation:Animals
  50. Fuchs TA, Brill A, Wagner DD. Neutrophil extracellular trap (NET) impact on deep vein thrombosis. Arterioscler Thromb Vasc Biol. 2012 Aug; 32(8):1777-83. PMID: 22652600.
    Citations: 73     Fields:    Translation:HumansAnimalsCells
  51. Brill A, Yesilaltay A, De Meyer SF, Kisucka J, Fuchs TA, Kocher O, Krieger M, Wagner DD. Extrahepatic high-density lipoprotein receptor SR-BI and apoA-I protect against deep vein thrombosis in mice. Arterioscler Thromb Vasc Biol. 2012 Aug; 32(8):1841-7. PMID: 22652597.
    Citations: 15     Fields:    Translation:AnimalsCells
  52. De Meyer SF, Suidan GL, Fuchs TA, Monestier M, Wagner DD. Extracellular chromatin is an important mediator of ischemic stroke in mice. Arterioscler Thromb Vasc Biol. 2012 Aug; 32(8):1884-91. PMID: 22628431.
    Citations: 39     Fields:    Translation:AnimalsCells
  53. Fuchs TA, Kremer Hovinga JA, Schatzberg D, Wagner DD, Lämmle B. Circulating DNA and myeloperoxidase indicate disease activity in patients with thrombotic microangiopathies. Blood. 2012 Aug 09; 120(6):1157-64. PMID: 22611154.
    Citations: 44     Fields:    Translation:HumansCells
  54. Thomas GM, Carbo C, Curtis BR, Martinod K, Mazo IB, Schatzberg D, Cifuni SM, Fuchs TA, von Andrian UH, Hartwig JH, Aster RH, Wagner DD. Extracellular DNA traps are associated with the pathogenesis of TRALI in humans and mice. Blood. 2012 Jun 28; 119(26):6335-43. PMID: 22596262.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  55. von Brühl ML, Stark K, Steinhart A, Chandraratne S, Konrad I, Lorenz M, Khandoga A, Tirniceriu A, Coletti R, Köllnberger M, Byrne RA, Laitinen I, Walch A, Brill A, Pfeiler S, Manukyan D, Braun S, Lange P, Riegger J, Ware J, Eckart A, Haidari S, Rudelius M, Schulz C, Echtler K, Brinkmann V, Schwaiger M, Preissner KT, Wagner DD, Mackman N, Engelmann B, Massberg S. Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo. J Exp Med. 2012 Apr 09; 209(4):819-35. PMID: 22451716.
    Citations: 259     Fields:    Translation:AnimalsCells
  56. Siller-Matula JM, Merhi Y, Tanguay JF, Duerschmied D, Wagner DD, McGinness KE, Pendergrast PS, Chung JK, Tian X, Schaub RG, Jilma B. ARC15105 is a potent antagonist of von Willebrand factor mediated platelet activation and adhesion. Arterioscler Thromb Vasc Biol. 2012 Apr; 32(4):902-9. PMID: 22282355.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  57. Brill A, Fuchs TA, Savchenko AS, Thomas GM, Martinod K, De Meyer SF, Bhandari AA, Wagner DD. Neutrophil extracellular traps promote deep vein thrombosis in mice. J Thromb Haemost. 2012 Jan; 10(1):136-44. PMID: 22044575.
    Citations: 160     Fields:    Translation:AnimalsCells
  58. Demers M, Wagner DD. Targeting platelet function to improve drug delivery. Oncoimmunology. 2012 Jan 01; 1(1):100-102. PMID: 22720224.
    Citations: 4     
  59. De Meyer SF, Stoll G, Wagner DD, Kleinschnitz C. von Willebrand factor: an emerging target in stroke therapy. Stroke. 2012 Feb; 43(2):599-606. PMID: 22180250.
    Citations: 39     Fields:    Translation:HumansCells
  60. Jansen AJ, Josefsson EC, Rumjantseva V, Liu QP, Falet H, Bergmeier W, Cifuni SM, Sackstein R, von Andrian UH, Wagner DD, Hartwig JH, Hoffmeister KM. Desialylation accelerates platelet clearance after refrigeration and initiates GPIba metalloproteinase-mediated cleavage in mice. Blood. 2012 Feb 02; 119(5):1263-73. PMID: 22101895.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  61. De Meyer SF, Schwarz T, Schatzberg D, Wagner DD. Platelet glycoprotein Iba is an important mediator of ischemic stroke in mice. Exp Transl Stroke Med. 2011 Sep 13; 3:9. PMID: 21914206.
    Citations: 8     
  62. Ho-Tin-Noé B, Demers M, Wagner DD. How platelets safeguard vascular integrity. J Thromb Haemost. 2011 Jul; 9 Suppl 1:56-65. PMID: 21781242.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  63. Fuchs TA, Bhandari AA, Wagner DD. Histones induce rapid and profound thrombocytopenia in mice. Blood. 2011 Sep 29; 118(13):3708-14. PMID: 21700775.
    Citations: 84     Fields:    Translation:AnimalsCells
  64. Stadtmann A, Brinkhaus L, Mueller H, Rossaint J, Bolomini-Vittori M, Bergmeier W, Van Aken H, Wagner DD, Laudanna C, Ley K, Zarbock A. Rap1a activation by CalDAG-GEFI and p38 MAPK is involved in E-selectin-dependent slow leukocyte rolling. Eur J Immunol. 2011 Jul; 41(7):2074-85. PMID: 21480213.
    Citations: 35     Fields:    Translation:AnimalsCells
  65. Flick MJ, Chauhan AK, Frederick M, Talmage KE, Kombrinck KW, Miller W, Mullins ES, Palumbo JS, Zheng X, Esmon NL, Esmon CT, Thornton S, Becker A, Pelc LA, Di Cera E, Wagner DD, Degen JL. The development of inflammatory joint disease is attenuated in mice expressing the anticoagulant prothrombin mutant W215A/E217A. Blood. 2011 Jun 09; 117(23):6326-37. PMID: 21436072.
    Citations: 14     Fields:    Translation:HumansAnimals
  66. Demers M, Ho-Tin-Noé B, Schatzberg D, Yang JJ, Wagner DD. Increased efficacy of breast cancer chemotherapy in thrombocytopenic mice. Cancer Res. 2011 Mar 01; 71(5):1540-9. PMID: 21212409.
    Citations: 15     Fields:    Translation:Animals
  67. Brill A, Fuchs TA, Chauhan AK, Yang JJ, De Meyer SF, Köllnberger M, Wakefield TW, Lämmle B, Massberg S, Wagner DD. von Willebrand factor-mediated platelet adhesion is critical for deep vein thrombosis in mouse models. Blood. 2011 Jan 27; 117(4):1400-7. PMID: 20959603.
    Citations: 90     Fields:    Translation:HumansAnimals
  68. Canault M, Certel K, Schatzberg D, Wagner DD, Hynes RO. The lack of ADAM17 activity during embryonic development causes hemorrhage and impairs vessel formation. PLoS One. 2010 Oct 15; 5(10):e13433. PMID: 20976179.
    Citations: 11     Fields:    Translation:AnimalsCells
  69. Fuchs TA, Brill A, Duerschmied D, Schatzberg D, Monestier M, Myers DD, Wrobleski SK, Wakefield TW, Hartwig JH, Wagner DD. Extracellular DNA traps promote thrombosis. Proc Natl Acad Sci U S A. 2010 Sep 07; 107(36):15880-5. PMID: 20798043.
    Citations: 340     Fields:    Translation:HumansAnimals
  70. Falet H, Pollitt AY, Begonja AJ, Weber SE, Duerschmied D, Wagner DD, Watson SP, Hartwig JH. A novel interaction between FlnA and Syk regulates platelet ITAM-mediated receptor signaling and function. J Exp Med. 2010 Aug 30; 207(9):1967-79. PMID: 20713593.
    Citations: 32     Fields:    Translation:AnimalsCells
  71. Carbo C, Duerschmied D, Goerge T, Hattori H, Sakai J, Cifuni SM, White GC, Chrzanowska-Wodnicka M, Luo HR, Wagner DD. Integrin-independent role of CalDAG-GEFI in neutrophil chemotaxis. J Leukoc Biol. 2010 Aug; 88(2):313-9. PMID: 20413728.
    Citations: 10     Fields:    Translation:AnimalsCells
  72. Canault M, Duerschmied D, Brill A, Stefanini L, Schatzberg D, Cifuni SM, Bergmeier W, Wagner DD. p38 mitogen-activated protein kinase activation during platelet storage: consequences for platelet recovery and hemostatic function in vivo. Blood. 2010 Mar 04; 115(9):1835-42. PMID: 19965619.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  73. Ho-Tin-Noé B, Carbo C, Demers M, Cifuni SM, Goerge T, Wagner DD. Innate immune cells induce hemorrhage in tumors during thrombocytopenia. Am J Pathol. 2009 Oct; 175(4):1699-708. PMID: 19729481.
    Citations: 33     Fields:    Translation:AnimalsCells
  74. Zhao BQ, Chauhan AK, Canault M, Patten IS, Yang JJ, Dockal M, Scheiflinger F, Wagner DD. von Willebrand factor-cleaving protease ADAMTS13 reduces ischemic brain injury in experimental stroke. Blood. 2009 Oct 08; 114(15):3329-34. PMID: 19687510.
    Citations: 61     Fields:    Translation:HumansAnimals
  75. Ho-Tin-Noé B, Goerge T, Wagner DD. Platelets: guardians of tumor vasculature. Cancer Res. 2009 Jul 15; 69(14):5623-6. PMID: 19584268.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  76. Bernimoulin M, Waters EK, Foy M, Steele BM, Sullivan M, Falet H, Walsh MT, Barteneva N, Geng JG, Hartwig JH, Maguire PB, Wagner DD. Differential stimulation of monocytic cells results in distinct populations of microparticles. J Thromb Haemost. 2009 Jun; 7(6):1019-28. PMID: 19548909.
    Citations: 33     Fields:    Translation:HumansCells
  77. Brill A, Chauhan AK, Canault M, Walsh MT, Bergmeier W, Wagner DD. Oxidative stress activates ADAM17/TACE and induces its target receptor shedding in platelets in a p38-dependent fashion. Cardiovasc Res. 2009 Oct 01; 84(1):137-44. PMID: 19482949.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  78. Walshe TE, Dole VS, Maharaj AS, Patten IS, Wagner DD, D'Amore PA. Inhibition of VEGF or TGF-{beta} signaling activates endothelium and increases leukocyte rolling. Arterioscler Thromb Vasc Biol. 2009 Aug; 29(8):1185-92. PMID: 19461051.
    Citations: 21     Fields:    Translation:AnimalsCells
  79. Duerschmied D, Canault M, Lievens D, Brill A, Cifuni SM, Bader M, Wagner DD. Serotonin stimulates platelet receptor shedding by tumor necrosis factor-alpha-converting enzyme (ADAM17). J Thromb Haemost. 2009 Jul; 7(7):1163-71. PMID: 19426283.
    Citations: 9     Fields:    Translation:AnimalsCells
  80. Diener JL, Daniel Lagassé HA, Duerschmied D, Merhi Y, Tanguay JF, Hutabarat R, Gilbert J, Wagner DD, Schaub R. Inhibition of von Willebrand factor-mediated platelet activation and thrombosis by the anti-von Willebrand factor A1-domain aptamer ARC1779. J Thromb Haemost. 2009 Jul; 7(7):1155-62. PMID: 19422452.
    Citations: 33     Fields:    Translation:AnimalsCells
  81. Kisucka J, Chauhan AK, Zhao BQ, Patten IS, Yesilaltay A, Krieger M, Wagner DD. Elevated levels of soluble P-selectin in mice alter blood-brain barrier function, exacerbate stroke, and promote atherosclerosis. Blood. 2009 Jun 04; 113(23):6015-22. PMID: 19349621.
    Citations: 20     Fields:    Translation:Animals
  82. Banno F, Chauhan AK, Kokame K, Yang J, Miyata S, Wagner DD, Miyata T. The distal carboxyl-terminal domains of ADAMTS13 are required for regulation of in vivo thrombus formation. Blood. 2009 May 21; 113(21):5323-9. PMID: 19109562.
    Citations: 29     Fields:    Translation:AnimalsCells
  83. Lu F, Chauhan AK, Fernandes SM, Walsh MT, Wagner DD, Davis AE. The effect of C1 inhibitor on intestinal ischemia and reperfusion injury. Am J Physiol Gastrointest Liver Physiol. 2008 Nov; 295(5):G1042-9. PMID: 18787060.
    Citations: 8     Fields:    Translation:AnimalsCells
  84. Ho-Tin-Noé B, Goerge T, Cifuni SM, Duerschmied D, Wagner DD. Platelet granule secretion continuously prevents intratumor hemorrhage. Cancer Res. 2008 Aug 15; 68(16):6851-8. PMID: 18701510.
    Citations: 59     Fields:    Translation:AnimalsCells
  85. Chauhan AK, Kisucka J, Brill A, Walsh MT, Scheiflinger F, Wagner DD. ADAMTS13: a new link between thrombosis and inflammation. J Exp Med. 2008 Sep 01; 205(9):2065-74. PMID: 18695007.
    Citations: 58     Fields:    Translation:AnimalsCells
  86. Kisucka J, Chauhan AK, Patten IS, Yesilaltay A, Neumann C, Van Etten RA, Krieger M, Wagner DD. Peroxiredoxin1 prevents excessive endothelial activation and early atherosclerosis. Circ Res. 2008 Sep 12; 103(6):598-605. PMID: 18689572.
    Citations: 28     Fields:    Translation:Animals
  87. Noubade R, del Rio R, McElvany B, Zachary JF, Millward JM, Wagner DD, Offner H, Blankenhorn EP, Teuscher C. von-Willebrand factor influences blood brain barrier permeability and brain inflammation in experimental allergic encephalomyelitis. Am J Pathol. 2008 Sep; 173(3):892-900. PMID: 18688020.
    Citations: 9     Fields:    Translation:AnimalsCells
  88. Cifuni SM, Wagner DD, Bergmeier W. CalDAG-GEFI and protein kinase C represent alternative pathways leading to activation of integrin alphaIIbbeta3 in platelets. Blood. 2008 Sep 01; 112(5):1696-703. PMID: 18544684.
    Citations: 38     Fields:    Translation:AnimalsCells
  89. Wagner DD, Frenette PS. The vessel wall and its interactions. Blood. 2008 Jun 01; 111(11):5271-81. PMID: 18502843.
    Citations: 86     Fields:    Translation:HumansAnimalsCells
  90. Dole VS, Matuskova J, Vasile E, Yesilaltay A, Bergmeier W, Bernimoulin M, Wagner DD, Krieger M. Thrombocytopenia and platelet abnormalities in high-density lipoprotein receptor-deficient mice. Arterioscler Thromb Vasc Biol. 2008 Jun; 28(6):1111-6. PMID: 18436807.
    Citations: 25     Fields:    Translation:AnimalsCells
  91. Goerge T, Ho-Tin-Noe B, Carbo C, Benarafa C, Remold-O'Donnell E, Zhao BQ, Cifuni SM, Wagner DD. Inflammation induces hemorrhage in thrombocytopenia. Blood. 2008 May 15; 111(10):4958-64. PMID: 18256319.
    Citations: 64     Fields:    Translation:AnimalsCells
  92. Wagner D, Hörster R, Lange B, Lange C. [Evaluation of T-cell interferon-gamma-release assays for the diagnosis of latent and active tuberculosis]. Dtsch Med Wochenschr. 2008 Feb; 133(8):354-7. PMID: 18270916.
    Citations: 2     Fields:    Translation:HumansCellsPHPublic Health
  93. Bergmeier W, Chauhan AK, Wagner DD. Glycoprotein Ibalpha and von Willebrand factor in primary platelet adhesion and thrombus formation: lessons from mutant mice. Thromb Haemost. 2008 Feb; 99(2):264-70. PMID: 18278173.
    Citations: 22     Fields:    Translation:AnimalsCells
  94. Chauhan AK, Walsh MT, Zhu G, Ginsburg D, Wagner DD, Motto DG. The combined roles of ADAMTS13 and VWF in murine models of TTP, endotoxemia, and thrombosis. Blood. 2008 Apr 01; 111(7):3452-7. PMID: 18083848.
    Citations: 23     Fields:    Translation:HumansAnimals
  95. Chauhan AK, Kisucka J, Cozzi MR, Walsh MT, Moretti FA, Battiston M, Mazzucato M, De Marco L, Baralle FE, Wagner DD, Muro AF. Prothrombotic effects of fibronectin isoforms containing the EDA domain. Arterioscler Thromb Vasc Biol. 2008 Feb; 28(2):296-301. PMID: 17991876.
    Citations: 15     Fields:    Translation:AnimalsCells
  96. Frederix K, Chauhan AK, Kisucka J, Zhao BQ, Hoff EI, Spronk HM, Ten Cate H, Wagner DD. Platelet adhesion receptors do not modulate infarct volume after a photochemically induced stroke in mice. Brain Res. 2007 Dec 14; 1185:239-45. PMID: 17996853.
    Citations: 3     Fields:    Translation:Animals
  97. Dole VS, Bergmeier W, Patten IS, Hirahashi J, Mayadas TN, Wagner DD. PSGL-1 regulates platelet P-selectin-mediated endothelial activation and shedding of P-selectin from activated platelets. Thromb Haemost. 2007 Oct; 98(4):806-12. PMID: 17938805.
    Citations: 14     Fields:    Translation:AnimalsCells
  98. Junt T, Schulze H, Chen Z, Massberg S, Goerge T, Krueger A, Wagner DD, Graf T, Italiano JE, Shivdasani RA, von Andrian UH. Dynamic visualization of thrombopoiesis within bone marrow. Science. 2007 Sep 21; 317(5845):1767-70. PMID: 17885137.
    Citations: 175     Fields:    Translation:AnimalsCells
  99. Bergmeier W, Goerge T, Wang HW, Crittenden JR, Baldwin AC, Cifuni SM, Housman DE, Graybiel AM, Wagner DD. Mice lacking the signaling molecule CalDAG-GEFI represent a model for leukocyte adhesion deficiency type III. J Clin Invest. 2007 Jun; 117(6):1699-707. PMID: 17492052.
    Citations: 68     Fields:    Translation:HumansAnimalsCells
  100. Krüger K, Wagner D, Gawenda M, Strohe D, Uedelhoven J, Brunkwall J, Lackner K. [Coil embolization of arteriovenous fistulae on in situ saphenous vein bypasses: success rate and complications]. Rofo. 2007 Jun; 179(6):587-92. PMID: 17492541.
    Citations: 2     Fields:    Translation:Humans
  101. Babic AM, Josefsson EC, Bergmeier W, Wagner DD, Kaufman RM, Silberstein LE, Stossel TP, Hartwig JH, Hoffmeister KM. In vitro function and phagocytosis of galactosylated platelet concentrates after long-term refrigeration. Transfusion. 2007 Mar; 47(3):442-51. PMID: 17319824.
    Citations: 12     Fields:    Translation:HumansCells
  102. Denis CV, Wagner DD. Platelet adhesion receptors and their ligands in mouse models of thrombosis. Arterioscler Thromb Vasc Biol. 2007 Apr; 27(4):728-39. PMID: 17272754.
    Citations: 37     Fields:    Translation:AnimalsCells
  103. Zhu L, Bergmeier W, Wu J, Jiang H, Stalker TJ, Cieslak M, Fan R, Boumsell L, Kumanogoh A, Kikutani H, Tamagnone L, Wagner DD, Milla ME, Brass LF. Regulated surface expression and shedding support a dual role for semaphorin 4D in platelet responses to vascular injury. Proc Natl Acad Sci U S A. 2007 Jan 30; 104(5):1621-6. PMID: 17244710.
    Citations: 67     Fields:    Translation:HumansAnimalsCells
  104. Chauhan AK, Goerge T, Schneider SW, Wagner DD. Formation of platelet strings and microthrombi in the presence of ADAMTS-13 inhibitor does not require P-selectin or beta3 integrin. J Thromb Haemost. 2007 Mar; 5(3):583-9. PMID: 17166247.
    Citations: 19     Fields:    Translation:AnimalsCells
  105. Chauhan AK, Kisucka J, Lamb CB, Bergmeier W, Wagner DD. von Willebrand factor and factor VIII are independently required to form stable occlusive thrombi in injured veins. Blood. 2007 Mar 15; 109(6):2424-9. PMID: 17119108.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  106. Bergmeier W, Piffath CL, Goerge T, Cifuni SM, Ruggeri ZM, Ware J, Wagner DD. The role of platelet adhesion receptor GPIbalpha far exceeds that of its main ligand, von Willebrand factor, in arterial thrombosis. Proc Natl Acad Sci U S A. 2006 Nov 07; 103(45):16900-5. PMID: 17075060.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  107. Hirahashi J, Mekala D, Van Ziffle J, Xiao L, Saffaripour S, Wagner DD, Shapiro SD, Lowell C, Mayadas TN. Mac-1 signaling via Src-family and Syk kinases results in elastase-dependent thrombohemorrhagic vasculopathy. Immunity. 2006 Aug; 25(2):271-83. PMID: 16872848.
    Citations: 45     Fields:    Translation:AnimalsCells
  108. Hafezi-Moghadam A, Thomas KL, Wagner DD. ApoE deficiency leads to a progressive age-dependent blood-brain barrier leakage. Am J Physiol Cell Physiol. 2007 Apr; 292(4):C1256-62. PMID: 16870825.
    Citations: 46     Fields:    Translation:Animals
  109. Yang H, Reheman A, Chen P, Zhu G, Hynes RO, Freedman J, Wagner DD, Ni H. Fibrinogen and von Willebrand factor-independent platelet aggregation in vitro and in vivo. J Thromb Haemost. 2006 Oct; 4(10):2230-7. PMID: 16824188.
    Citations: 22     Fields:    Translation:AnimalsCells
  110. Yang D, Zhang Y, Nguyen HG, Koupenova M, Chauhan AK, Makitalo M, Jones MR, St Hilaire C, Seldin DC, Toselli P, Lamperti E, Schreiber BM, Gavras H, Wagner DD, Ravid K. The A2B adenosine receptor protects against inflammation and excessive vascular adhesion. J Clin Invest. 2006 Jul; 116(7):1913-23. PMID: 16823489.
    Citations: 150     Fields:    Translation:Anim