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Matthew Peter Anderson, Ph.D., M.D.

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Biography
1993
International Distinguished Dissertation Award
1997
HHMI Research Fellowship for Physicians Award
2000
Career Award in the Biomedical Sciences
2000
Research Career Development Award
2006 - 2011
Independent Scientist Award

Overview
During my PhD research with HHMI Investigator Michael J. Welsh, we established CFTR, the gene mutated to cause the most common Caucasian lethal genetic disease cystic fibrosis (CF), encodes the epithelial apical membrane chloride channel essential for trans-epithelial ion and fluid secretion. CFTR cDNA induced chloride channels in diverse cell types (Anderson et al., Science, 1991a) and amino acids mutations in transmembrane domains altered pore properties (Anderson et al., Science, 1991b). Our work also established CFTR displays novel channel regulation by intracellular, hydrolysable, nucleoside triphosphates through the nucleotide binding domains (Anderson et al., Cell, 1991; Anderson et al., Science, 1992), clarifying the enigma that CFTR was not a known member of any ion channel gene family, but instead resembled a family of ATP hydrolyzing ABC transporter proteins (pumps). More importantly, the results explained how CF mutations cause disease.

During the interval from 1993-2000, I had a hiatus from research, finishing my MD-PhD training with clinical rotations in medical school, residency clinical training in anatomic pathology (University of Iowa College of Medicine), subspecialty fellowship training in neuropathology (Brigham and Women’s Hospital; Boston Children’s Hospital; and Massachusetts General Hospital), and board certification in both clinical fields. From 1998-2003, I practiced medicine as a Senior Staff Physician at Brigham and Women’s Hospital, Boston Children’s Hospital, and then at Massachusetts General Hospital with neuropathology case sign out responsibilities. Partially overlapping this clinical practice period from 2000-2005, I initiated my postdoctoral research fellowship training to expand my research skill set, and transition my biomedical research from epithelial transport/ion channel biophysics to neuroscience/molecular mouse genetics. This phase of training took place with Nobel Laureate and HHMI Investigatory Susumu Tonegawa at MIT where I acquired expertise in the following areas: neuroscience, conditional mouse genetics, bacterial artificial chromosome gene molecular engineering, mouse sleep physiology, mouse behavioral analysis, and brain slice whole cell patch clamp electrophysiology. During this time, I also trained in the implantation of microdrives onto mice for in vivo multi-unit tetrode wire electrophysiology recording of hippocampus in awake behaving mice with the laboratory Professor Matt Wilson at MIT. As is typical and expected of trainees in the Tonegawa lab, a single seminal study was published after 5-6 years of personally engineering two new conditional mouse genetic lines, developing slice whole cell patch clamp of thalamus, and performing in vivo electrophysiologic recordings to publish this work. The subjects and methods were novel to the Tonegawa Lab that had primarily been focused on learning and memory and synaptic plasticity.

My studies examined the function of ion channels mediating burst firing, prominent in thalamus during sleep. Cre/loxP-based conditional mouse genetics were developed to identify a novel form of insomnia produced when T-type Ca2+ channel Cav3.1 is selectively inactivated in thalamus. This was the first and only example of selective gene manipulation in thalamus, now available at JAXS lab (Tg(Kcnc2-cre)K128Stl). In aggregate, the studies identified a brain region and cellular mechanism for a novel sleep disorder (Anderson et al., PNAS, 2005). The brain slice electrophysiology data in the manuscript were actually performed in my own laboratory at Harvard Medical School and Beth Israel Deaconess Medical Center.

In my own laboratory, beginning in 2005/2006, I reconstituted the techniques of my two former mentor’s laboratories. Using this repertoire of techniques, my lab then generated a new mouse model of a human epilepsy disorder due to mutations in LGI1, performed brain slice whole cell patch clamp electrophysiology to interrogate hippocampal circuits, and utilized in vivo extracellular recordings of cortical and hippocampal neuronal activity to examine seizure susceptibility. We discovered that the human epilepsy gene, LGI1, is mutated to arrest postnatal development of glutamatergic circuits (Zhou et al. Nature Medicine, 2009; NINDS R01NS057444-01), revealing a novel mechanism for human epilepsy and uncovering a key molecular pathway in childhood brain development (News and Views, Nature Medicine, 2009; Anderson. Epilepsy Currents, 2010). In manuscripts under revision or submitted, we have subsequently established that LGI1 regulates axonal pruning in the thalamic retinogeniculate circuit during postnatal childhood brain (Zhou et al. J Neuroscience 2011) and regulates the adaptive homeostatic response of thalamic neuronal circuits to a seizure (Smith et al. J Neurochemistry 2011), both providing further insights into the pathophysiological basis of this human epilepsy.

In other work currently also under revision, we created a mouse transgenic model of human epilepsy associated with T-type Ca2+ channel Cav3.2 mutations (NINDS K02 NS054674) and report an age-dependent promotion of spontaneous network discharge that is magnified by a prior seizure (environment) and an epilepsy-associated mutation (gene) leading to a gene-environment-developmental age interaction model of human childhood absence epilepsy.

In a manuscript developed through a collaborative study on hypothalamic circuit repair under revision (Science 2011, collaborating with Drs. Jeffrey Flier and Jeffrey Mackliss), my lab used fluorescence-guided whole-cell, patch-clamp to analyze fluorescent progenitor transplanted neurons in hypothalamic brain slices. The study evaluates whether transplanted progenitors can functionally incorporate into the adult hypothalamus to rescue obesity due to leptin receptor deficiency. GFP-positive neural progenitors incorporate into hypothalamic circuitries, again as a large variety of neuronal subtypes. Furthermore, reconstituting the leptin responsive functions of the local hypothalamic circuitry partially ameliorated the obesity phenotype. In a second collaborative study with Dr. Jeffrey Flier’s lab, we evaluated whether functional neurogenesis continues in adult hypothalamus. Adult neurogenesis is currently only well established in dentate gyrus (one neuronal subtype) and olfactory bulb (two neuronal subtypes). Using retroviral (GFP) labeling, newly generated cells in the adult hypothalamus were shown to be electrophysiologically active neurons. Unlike these other two adult neurogenesis zones, hypothalamus generated at least three distinct neuronal subtypes (electrophysiological properties). Furthermore, newborn hypothalamic neurons form both excitatory and inhibitory synaptic connection with other neurons within native hypothalamus established via paired neuron recordings.

Currently, a major effort of my laboratory is to uncover the cellular mechanisms of human autism and schizophrenia, focusing on recently reported genomic copy number variations. We recently succeeded in reconstituting all three core autism behavioral traits (impaired social interaction, reduced vocal communication, and repetitive self grooming behavior) in a model of the most common human genetic autism disorder due to copy number variations, 15q11-13 duplication (inv dup15) and triplication (isodicentric chromosome, idic15) (NINDS R21 ARRA Heterogeneity in Autism Disorder Grant 1R21NS070295-01; Science Translational Medicine 2011; patent filed). We also identified underlying circuit defects that could be important in generating some of the behavioral deficits. We are also developing mouse models of schizophrenia due to the most common copy number variation, 16p11.2 duplication, and to investigate the underlying circuit defects.

In summary, my laboratory now merges these diverse training experiences combining mouse genetic engineering, behavioral analysis, in vivo electrophysiology, and ultrastructural, biochemical, and in vitro patch clamp electrophysiological analysis of neuronal circuitries to gain insights into the pathophysiological mechanisms of neurodevelopmental disorders including autism, schizophrenia, and epilepsy.

Mentoring
Available: 07/10/17, Expires: 07/10/20

Recent studies have uncovered microduplications of small segments of the human genome in association with autism and epilepsy. We recreate these microduplications using transgenic mice and investigate the resulting behavioral and circuit defects to gain insight into the mechanisms of these disorders. Projects are available that range from the creation of new genetic mouse models, to the analysis of social and communication behaviors, to the analysis of neuronal circuits at the structural and functional level. See our recent publication Krishnan et al. Nature 2017 for details.

Pathogenesis of Autism[login at prompt]
Available: 07/10/17, Expires: 07/13/20

There are three potential projects related to autism: 1. Studies of the postmortem human brain from individuals with autism - define molecular and cellular changes underlying autism 2. Studies of the circuit and molecular mechanisms in mouse models of human genetic autism - participate in the analysis of changes in gene expression - participate in the analysis of changes in behavior - participate in the analysis of changes in neuronal circuits 3. Human species-specific molecular mechanisms involving autism genes that enhanced neuronal function during hominid evolution - participate in gene expression studies - participate in neuronal morphological studies - participate in neuronal electrophysiology studies

Identifying transposable elements in the human and mouse genomes contributing to differences of expression of orthologous genes between human and mouse
Summer, 06/16/14 - 08/04/14
Design and construction of a mouse disease model for a novel candidate gene associated with autism spectrum disorders
Summer, 06/14/10 - 08/16/10
Activation of the medial amygdala in socially isolated and group housed mice following social interaction
Summer, 06/20/11 - 08/12/11

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01MH112714 (ANDERSON, MATTHEW P) May 1, 2018 - Jan 31, 2023
    NIH/NIMH
    VTA VGluT2 Sociability Circuit in Genetic Autism
    Role: Principal Investigator
  2. R01MH114858 (ANDERSON, MATTHEW P) Sep 12, 2017 - May 31, 2022
    NIH/NIMH
    Neurobiology of Aggression Comorbidity in Autism
    Role: Principal Investigator
  3. R21HD079249 (ANDERSON, MATTHEW P) Jun 15, 2014 - May 31, 2016
    NIH/NICHD
    Conditional Genetics Rescue of Angelman Syndrome
    Role: Principal Investigator
  4. R21MH100868 (ANDERSON, MATTHEW P) Jun 1, 2013 - Apr 30, 2015
    NIH/NIMH
    Neurobiology of Aggression Co-morbidity in Mouse Model of Idic15 Autism
    Role: Principal Investigator
  5. R01NS081916 (ANDERSON, MATTHEW P) Sep 1, 2012 - Aug 31, 2017
    NIH/NINDS
    Neurobiological Mechanism of 15q11-13 Duplication Autism Spectrum Disorder
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Nakanishi M, Anderson MP, Takumi T. Recent genetic and functional insights in autism spectrum disorder. Curr Opin Neurol. 2019 May 22. PMID: 31135459.
    Citations:    
  2. Anderson MP. DEPDC5 takes a second hit in familial focal epilepsy. J Clin Invest. 2018 Jun 01; 128(6):2194-2196. PMID: 29708509.
    Citations:    Fields:    
  3. Amaral DG, Anderson MP, Ansorge O, Chance S, Hare C, Hof PR, Miller M, Nagakura I, Pickett J, Schumann C, Tamminga C. Autism BrainNet: A network of postmortem brain banks established to facilitate autism research. Handb Clin Neurol. 2018; 150:31-39. PMID: 29496150.
    Citations:    Fields:    Translation:Humans
  4. Laviv Y, Wang JL, Anderson MP, Kasper EM. Accelerated growth of hemangioblastoma in pregnancy: the role of proangiogenic factors and upregulation of hypoxia-inducible factor (HIF) in a non-oxygen-dependent pathway. Neurosurg Rev. 2019 Jun; 42(2):209-226. PMID: 29027018.
    Citations: 1     Fields:    
  5. Kasper EM, Ippen FM, Maragkos GA, Anderson MP, Rojas R, Mahadevan A. Tanycytic ependymoma of the brain stem, presentations of rare cystic disease variants and review of literature. J Neurosurg Sci. 2018 Feb; 62(1):78-88. PMID: 28884561.
    Citations:    Fields:    Translation:HumansCells
  6. Stoppel DC, Anderson MP. Hypersociability in the Angelman syndrome mouse model. Exp Neurol. 2017 07; 293:137-143. PMID: 28411125.
    Citations: 2     Fields:    Translation:Animals
  7. Krishnan V, Stoppel DC, Nong Y, Johnson MA, Nadler MJ, Ozkaynak E, Teng BL, Nagakura I, Mohammad F, Silva MA, Peterson S, Cruz TJ, Kasper EM, Arnaout R, Anderson MP. Autism gene Ube3a and seizures impair sociability by repressing VTA Cbln1. Nature. 2017 03 23; 543(7646):507-512. PMID: 28297715.
    Citations: 10     Fields:    Translation:AnimalsCells
  8. Wüthrich C, Batson S, Anderson MP, White LR, Koralnik IJ. JC Virus Infects Neurons and Glial Cells in the Hippocampus. J Neuropathol Exp Neurol. 2016 Jun 12. PMID: 27297673.
    Citations:    Fields:    
  9. Wang H, Zhang X, Xue L, Xing J, Jouvin MH, Putney JW, Anderson MP, Trebak M, Kinet JP. Low-Voltage-Activated CaV3.1 Calcium Channels Shape T Helper Cell Cytokine Profiles. Immunity. 2016 Apr 19; 44(4):782-94. PMID: 27037192.
    Citations: 3     Fields:    Translation:AnimalsCells
  10. VanderHorst VG, Samardzic T, Saper CB, Anderson MP, Nag S, Schneider JA, Bennett DA, Buchman AS. a-Synuclein pathology accumulates in sacral spinal visceral sensory pathways. Ann Neurol. 2015 Jul; 78(1):142-9. PMID: 25893830.
    Citations: 10     Fields:    Translation:Humans
  11. Kasten MR, Anderson MP. Self-regulation of adult thalamocortical neurons. J Neurophysiol. 2015 Jul; 114(1):323-31. PMID: 25948871.
    Citations: 1     Fields:    Translation:AnimalsCells
  12. Anderson MP. Neuropathology of Autism Spectrum Disorder. Autism Spectrum Disorder, Christopher McDougle (Ed). 2015.
  13. Boillot M, Huneau C, Marsan E, Lehongre K, Navarro V, Ishida S, Dufresnois B, Ozkaynak E, Garrigue J, Miles R, Martin B, Leguern E, Anderson MP, Baulac S. Glutamatergic neuron-targeted loss of LGI1 epilepsy gene results in seizures. Brain. 2014 Nov; 137(Pt 11):2984-96. PMID: 25234641.
    Citations: 11     Fields:    Translation:AnimalsCells
  14. Khoury MN, Alsop DC, Agnihotri SP, Pfannl R, Wuthrich C, Ho ML, Hackney D, Ngo L, Anderson MP, Koralnik IJ. Hyperintense cortical signal on magnetic resonance imaging reflects focal leukocortical encephalitis and seizure risk in progressive multifocal leukoencephalopathy. Ann Neurol. 2014 May; 75(5):659-69. PMID: 24752885.
    Citations: 8     Fields:    Translation:Humans
  15. Krishnan V, Tarula E, Anderson MP, Hanafy KA, Herman ST. Postictal bradyarrhythmia following an isolated seizure in a patient with left hemisphere stroke. Seizure. 2013 Dec; 22(10):908-10. PMID: 23849848.
    Citations:    Fields:    Translation:Humans
  16. Smith SE, Elliott RM, Anderson MP. Maternal immune activation increases neonatal mouse cortex thickness and cell density. J Neuroimmune Pharmacol. 2012 Sep; 7(3):529-32. PMID: 22570011.
    Citations: 3     Fields:    Translation:Animals
  17. Smith SE, Xu L, Kasten MR, Anderson MP. Mutant LGI1 inhibits seizure-induced trafficking of Kv4.2 potassium channels. J Neurochem. 2012 Feb; 120(4):611-21. PMID: 22122031.
    Citations: 6     Fields:    Translation:AnimalsCells
  18. Zhou YD, Zhang D, Ozkaynak E, Wang X, Kasper EM, Leguern E, Baulac S, Anderson MP. Epilepsy gene LGI1 regulates postnatal developmental remodeling of retinogeniculate synapses. J Neurosci. 2012 Jan 18; 32(3):903-10. PMID: 22262888.
    Citations: 11     Fields:    Translation:AnimalsCells
  19. Czupryn A, Zhou YD, Chen X, McNay D, Anderson MP, Flier JS, Macklis JD. Transplanted hypothalamic neurons restore leptin signaling and ameliorate obesity in db/db mice. Science. 2011 Nov 25; 334(6059):1133-7. PMID: 22116886.
    Citations: 17     Fields:    Translation:AnimalsCells
  20. Smith SE, Zhou YD, Zhang G, Jin Z, Stoppel DC, Anderson MP. Increased gene dosage of Ube3a results in autism traits and decreased glutamate synaptic transmission in mice. Sci Transl Med. 2011 Oct 05; 3(103):103ra97. PMID: 21974935.
    Citations: 71     Fields:    Translation:AnimalsCells
  21. Anderson MP. Arrested glutamatergic synapse development in human partial epilepsy. Epilepsy Curr. 2010 Nov; 10(6):153-8. PMID: 21157544.
    Citations: 3     
  22. Zhou YD, Lee S, Jin Z, Wright M, Smith SE, Anderson MP. Arrested maturation of excitatory synapses in autosomal dominant lateral temporal lobe epilepsy. Nat Med. 2009 Oct; 15(10):1208-14. PMID: 19701204.
    Citations: 66     Fields:    Translation:HumansAnimalsCells
  23. Wüthrich C, Dang X, Westmoreland S, McKay J, Maheshwari A, Anderson MP, Ropper AH, Viscidi RP, Koralnik IJ. Fulminant JC virus encephalopathy with productive infection of cortical pyramidal neurons. Ann Neurol. 2009 Jun; 65(6):742-8. PMID: 19557867.
    Citations: 40     Fields:    Translation:HumansCells
  24. Peri N, Lee PH, Anderson MP, Bhadelia RA. Acute infarction of meningioma demonstrated by diffusion-weighted MR imaging. J Neurooncol. 2008 Dec; 90(3):275-8. PMID: 18726186.
    Citations: 2     Fields:    Translation:Humans
  25. Y-D Zhou, Lee S, Jin Z, Wright M, Anderson MP. Arrested developmental down-regulation of excitatory synapses in autosomal dominant lateral temporal lobe epilepsy. Society for Neuroscience Meeting Abstract. 2008.
  26. Kasten MR, Anderson MP. Epilepsy impairs in vitro thalamic signal processing. Society for Neuroscience Meeting Abstract. 2008.
  27. Anderson MP, Zhou Y-D, Lee S . Temporal lobe epilepsy-related protein Lgi1 regulates hippocampal perforant pathway glutamatergic synaptic transmission. 2007 American Epilepsy Society Annual Meeting, Philadelphia, PA. 2007.
  28. Kasten MR, Rudy B, Anderson MP. Differential regulation of action potential firing in adult murine thalamocortical neurons by Kv3.2, Kv1, and SK potassium and N-type calcium channels. J Physiol. 2007 Oct 15; 584(Pt 2):565-82. PMID: 17761775.
    Citations: 21     Fields:    Translation:AnimalsCells
  29. Anderson MP, Hooker BS, Herbert MR. Bridging from Cells to Cognition in Autism Pathophysiology: Biological Pathways to Defective Brain Function and Plasticity. Am. J. Biochem. Biotech. 2007.
  30. Anderson MP, Zhou Y-D, and Lee S. Effects of the human autosomal dominant lateral temporal lobe epilepsy gene LGI1 on the hippocampal dentate gyrus. Curing Epilepsy 2007 National Institutes of Neurological Diseases and Strokes, National Institutes of Health, Bethesda, Maryland. 2007.
  31. Kasten MR, Anderson MP. Auditory thalamus relay neuron defects in a mouse model of human autosomal dominant lateral temporal lobe epilepsy. Soc. Neurosci. Abstr. 2007. 2007; 165.12.
  32. Herbert MR, Anderson MP. Autism: Current Theories and Evidence. An Expanding Spectrum of Autism Models: From Static Defects in Development to Reversible Impairments of Function. 2007.
  33. Zhou Y-D, Lee S, Anderson MP. Temporal lobe epilepsy-related protein Lgi1 regulates hipppocampal perforant pathway synaptic transmission by reducing the probability of transmitter release. Soc. Neurosci. Abstr. 2007. 2007; 165.6.
  34. Kasten M, Lee S, Anderson MP. Auditory thalamus hyperexcitability in a mouse model of human autosomal dominant lateral temporal lobe epilepsy. Epilepsia. 2006; 47:289-373.
  35. Anderson MP, Mochizuki T, Xie J, Fischler W, Manger JP, Talley EM, Scammell TE, Tonegawa S. Thalamic Cav3.1 T-type Ca2+ channel plays a crucial role in stabilizing sleep. Proc Natl Acad Sci U S A. 2005 Feb 01; 102(5):1743-8. PMID: 15677322.
    Citations: 64     Fields:    Translation:Animals
  36. Lee S, Anderson MP. Defining the localization, membership, and function of the Cav3.1 T-type calcium channel protein complex using epitope-tagged CACNA1G transgenic mice. Soc. Neurosci. Abstr. 2005. 2005; 845.15.
  37. Kasten MR and Anderson MP. Self-inhibition of thalamic relay neurons through the synergistic activation of an unidentified potassium channel and the Cav3.1 T-type calcium channel. Soc. Neurosci. Abstr. 2005. 2005; 845.13.
  38. Zhou C, Anderson MP. Burst action potential firing of neurons in the central amygdala nucleus requires Cav3.1 T-type calcium channel [abstract]. Soc. Neurosci. Abstr. 2005. 2005; 845.16.
  39. Anderson, MP, Mochizuki, T, Scammell,T, Tonegawa, S. Region-restricted knockout of T-type calcium channel Cav3.1: subcortical neuron bursts stabilize NREM sleep. Associated Professional Sleep Societies' (APSS) 18th Annual Meeting, Philadelphia (PA). 2004.
  40. Anderson, MP, Tonegawa, S. Knockout of T-type calcium channel Cav3.1 implicates bursting in delayed fear and avoidance memory consolidation. Cold Spring Harbor Laboratory: Channels, Receptors & Synapses, Cold Spring Harbor (NY). 2004.
  41. Anderson, MP, Mochizuki, T, Manger, J., Talley, EM, Scammell,T, Tonegawa, S. Region-restricted knockout of T-type calcium channel Cav3.1: thalamic calcium spikes inhibit sodium spiking and arousal during sleep. Annual Society for Neuroscience Conference, San Diego (CA). 2004.
  42. Anderson, MP, Mochizuki, T., Manger, JP, Talley, EM, Scammell, TE, Tonegawa, S. Region-restricted knockout of T-type calcium channel Cav3.1: thalamic calcium spikes inhibit sodium spiking and arousal during sleep. 4th Annual Picower-Riken Neuroscience Symposium, Cambridge (MA). 2004.
  43. Anderson MP, Fischler W, Scammell T, Mochizuki T, Miyakawa T, Tonegawa S. . Slow wave sleep and fear memory consolidation defects in Alpha1G knockout mice. 3rd Annual RIKEN-MIT Neuroscience Symposium, Cambridge (MA). 2003.
  44. Anderson MP and Tonegawa S. Role of T-type calcium channels in forebrain synchronous and rhythmic neuronal activities. Picower Center for Learning and Memory Meeting, Kennebunkport (ME). 2002.
  45. Amato AA, Sanelli PC, Anderson MP. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 38-2001. A 51-year-old woman with lung cancer and neuropsychiatric abnormalities. N Engl J Med. 2001 Dec 13; 345(24):1758-65. PMID: 11742051.
    Citations:    Fields:    Translation:HumansCells
  46. Welsh MJ, Denning GM, Ostedgaard LS, Anderson MP. Dysfunction of CFTR bearing the delta F508 mutation. J Cell Sci Suppl. 1993; 17:235-9. PMID: 7511616.
    Citations: 8     Fields:    Translation:HumansCells
  47. Welsh MJ and Anderson MP. . Regulation of the CFTR Chloride Channel by MgATP. Chapter 9. Molecular Biology and Function of Carrier Proteins. 1993; 120-127.
  48. Welsh MJ, Anderson MP, Rich DP, Berger HA, and Sheppard DN. . The CFTR Chloride Channel. Current Topics in Membranes and Transport: Chloride Channels From Plants to Human Disease, W.B. Guggino (Ed). 1993.
  49. Anderson, MP. Function and regulation of the cystic fibrosis transmembrane conductance regulator. 1993.
  50. Welsh MJ, Anderson MP, Rich DP, Berger HA, Denning GM, Ostedgaard LS, Sheppard DN. Abnormalities of Airway Epithelial Chloride Transport in Cystic Fibrosis. Airway Secretion: Physiological Basis for the Control of Mucus Hypersecretion, T. Takishima(Ed). 1993.
  51. Welsh MJ, Anderson MP. Regulation of the cystic fibrosis transmembrane conductance regulator chloride channel by MgATP. Soc Gen Physiol Ser. 1993; 48:119-27. PMID: 7684867.
    Citations:    Fields:    Translation:HumansCells
  52. Welsh MJ, Anderson MP, Rich DP, Ostedgaard L, Gregory RJ, Cheng S, and Smith A.E. Cystic Fibrosis, CFTR and Abnormal Electrolyte Transport. Cystic Fibrosis, PB Davis C. Lenfant (Eds). 1993; 29-52.
  53. Cheng SH, Gregory RJ, Amara JF, Rich DP, Anderson M, Welsh MJ, and Smith AE. Intracellular Processing of CFTR as the Molecular Basis of Cystic Fibrosis. Current Topics in Cystic Fibrosis, Vol. 1, J. Dodge, D.J. Brock and J.M. Widdicombe (Eds). 1993; (Chapter 8):175-189.
  54. Anderson MP, Welsh MJ. Regulation by ATP and ADP of CFTR chloride channels that contain mutant nucleotide-binding domains. Science. 1992 Sep 18; 257(5077):1701-4. PMID: 1382316.
    Citations: 61     Fields:    Translation:AnimalsCells
  55. Denning GM, Anderson MP, Amara JF, Marshall J, Smith AE, Welsh MJ. Processing of mutant cystic fibrosis transmembrane conductance regulator is temperature-sensitive. Nature. 1992 Aug 27; 358(6389):761-4. PMID: 1380673.
    Citations: 374     Fields:    Translation:HumansAnimalsCells
  56. Anderson MP, Sheppard DN, Berger HA, Welsh MJ. Chloride channels in the apical membrane of normal and cystic fibrosis airway and intestinal epithelia. Am J Physiol. 1992 Jul; 263(1 Pt 1):L1-14. PMID: 1322048.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  57. Welsh MJ, Anderson MP, Rich DP, Berger HA, Denning GM, Ostedgaard LS, Sheppard DN, Cheng SH, Gregory RJ, Smith AE. Cystic fibrosis transmembrane conductance regulator: a chloride channel with novel regulation. Neuron. 1992 May; 8(5):821-9. PMID: 1375035.
    Citations: 40     Fields:    Translation:HumansCells
  58. Anderson MP, Rich DP, Gregory RJ, Cheng S, Smith AE, and Welsh MJ. Function and Regulation of the Cystic Fibrosis Transmembrane Conductance Regulator. Adenine Nucleotides in Cellular Energy Transfer and Signal Transduction. 1992; 388-413.
  59. Anderson MP, Berger HA, Rich DP, Gregory RJ, Smith AE, Welsh MJ. Nucleoside triphosphates are required to open the CFTR chloride channel. Cell. 1991 Nov 15; 67(4):775-84. PMID: 1718606.
    Citations: 131     Fields:    Translation:HumansAnimalsCells
  60. Berger HA, Anderson MP, Gregory RJ, Thompson S, Howard PW, Maurer RA, Mulligan R, Smith AE, Welsh MJ. Identification and regulation of the cystic fibrosis transmembrane conductance regulator-generated chloride channel. J Clin Invest. 1991 Oct; 88(4):1422-31. PMID: 1717515.
    Citations: 42     Fields:    Translation:HumansAnimals
  61. Gregory RJ, Rich DP, Cheng SH, Souza DW, Paul S, Manavalan P, Anderson MP, Welsh MJ, Smith AE. Maturation and function of cystic fibrosis transmembrane conductance regulator variants bearing mutations in putative nucleotide-binding domains 1 and 2. Mol Cell Biol. 1991 Aug; 11(8):3886-93. PMID: 1712898.
    Citations: 67     Fields:    Translation:HumansAnimalsCells
  62. Anderson MP, Welsh MJ. Calcium and cAMP activate different chloride channels in the apical membrane of normal and cystic fibrosis epithelia. Proc Natl Acad Sci U S A. 1991 Jul 15; 88(14):6003-7. PMID: 1712478.
    Citations: 97     Fields:    Translation:HumansCells
  63. Anderson MP, Gregory RJ, Thompson S, Souza DW, Paul S, Mulligan RC, Smith AE, Welsh MJ. Demonstration that CFTR is a chloride channel by alteration of its anion selectivity. Science. 1991 Jul 12; 253(5016):202-5. PMID: 1712984.
    Citations: 261     Fields:    Translation:HumansCells
  64. Rich DP, Gregory RJ, Anderson MP, Manavalan P, Smith AE, Welsh MJ. Effect of deleting the R domain on CFTR-generated chloride channels. Science. 1991 Jul 12; 253(5016):205-7. PMID: 1712985.
    Citations: 66     Fields:    Translation:HumansCells
  65. Anderson MP, Rich DP, Gregory RJ, Smith AE, Welsh MJ. Generation of cAMP-activated chloride currents by expression of CFTR. Science. 1991 Feb 08; 251(4994):679-82. PMID: 1704151.
    Citations: 116     Fields:    Translation:HumansAnimalsCells
  66. Anderson MP, and Welsh MJ. Regulation of Apical Membrane Chloride Channels by Phosphorylation and Fatty Acids in Normal and Cystic Fibrosis Airway Epithelium. Signaling Mechanisms in Secretory and Immune Cells. 1991; 1-5.
  67. Rich DP, Anderson MP, Gregory RJ, Cheng SH, Paul S, Jefferson DM, McCann JD, Klinger KW, Smith AE, Welsh MJ. Expression of cystic fibrosis transmembrane conductance regulator corrects defective chloride channel regulation in cystic fibrosis airway epithelial cells. Nature. 1990 Sep 27; 347(6291):358-63. PMID: 1699126.
    Citations: 136     Fields:    Translation:HumansCells
  68. Anderson MP, Welsh MJ. Fatty acids inhibit apical membrane chloride channels in airway epithelia. Proc Natl Acad Sci U S A. 1990 Sep; 87(18):7334-8. PMID: 1698296.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  69. Anderson MP, Welsh MJ. Isoproterenol, cAMP, and bradykinin stimulate diacylglycerol production in airway epithelium. Am J Physiol. 1990 Jun; 258(6 Pt 1):L294-300. PMID: 2163209.
    Citations: 3     Fields:    Translation:AnimalsCells
  70. Welsh MJ, McCann JD, Li M, Clancy JP and Anderson MP. Editorial. , 247:222, 1990. Chloride Channels in Cystic Fibrosis Patients. Science. 1990; 247:222.
  71. Li M, McCann JD, Anderson MP, Clancy JP, Liedtke CM, Nairn AC, Greengard P, Welsch MJ. Regulation of chloride channels by protein kinase C in normal and cystic fibrosis airway epithelia. Science. 1989 Jun 16; 244(4910):1353-6. PMID: 2472006.
    Citations: 54     Fields:    Translation:HumansCells
  72. Welsh MJ, Li M, McCann, JD, Clancy JP, and Anderson MP. Phosphorylation-Dependent Regulation of Apical Membrane Cl- Channels in Normal and CF Airway Epithelium. Mukoviszidose 1989: Ergebnisse aus Grundlagenforschung und Klinik. 1989; 122-125.
  73. Welsh MJ, Li M, McCann JD, Clancy JP, Anderson MP. Phosphorylation-dependent regulation of apical membrane chloride channels in normal and cystic fibrosis airway epithelium. Ann N Y Acad Sci. 1989; 574:44-51. PMID: 2561330.
    Citations:    Fields:    Translation:HumansCells
  74. Welsh MJ, Li M, McCann JD, Clancy JP, Anderson MP, Nairn AC, Greengard P, and Liedtke CM. . Regulation of Apical Membrane Chloride Channels From Normal and Cystic Fibrosis Airway Epithelium. Peds. Pulmonol. Suppl. 1989; 4:105-106.
  75. Jennings ML, Anderson MP, McCormick SJ. Functional roles of carboxyl groups in human red blood cell anion exchange. Soc Gen Physiol Ser. 1988; 43:163-80. PMID: 3077543.
    Citations:    Fields:    Translation:HumansCells
  76. Jennings ML, Anderson MP. Chemical modification and labeling of glutamate residues at the stilbenedisulfonate site of human red blood cell band 3 protein. J Biol Chem. 1987 Feb 05; 262(4):1691-7. PMID: 2879841.
    Citations: 14     Fields:    Translation:HumansCells
  77. Jennings ML, Anderson MP, Monaghan R. Monoclonal antibodies against human erythrocyte band 3 protein. Localization of proteolytic cleavage sites and stilbenedisulfonate-binding lysine residues. J Biol Chem. 1986 Jul 05; 261(19):9002-10. PMID: 3087983.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.