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M. Charles Liberman, PH.D.

Title
Institution
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Address
Phone
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Mentoring
completed student projects
Cell Proliferation in Pig Cranial Sutures
Summer, 06/21/04 - 08/20/04

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Wu PZ, Liberman LD, Bennett K, de Gruttola V, O'Malley JT, Liberman MC. Primary Neural Degeneration in the Human Cochlea: Evidence for Hidden Hearing Loss in the Aging Ear. Neuroscience. 2018 Aug 10. PMID: 30099118.
    View in: PubMed
  2. Hickman TT, Smalt C, Bobrow J, Quatieri T, Liberman MC. Blast-induced cochlear synaptopathy in chinchillas. Sci Rep. 2018 Jul 16; 8(1):10740. PMID: 30013117.
    View in: PubMed
  3. Valero MD, Hancock KE, Maison SF, Liberman MC. Effects of cochlear synaptopathy on middle-ear muscle reflexes in unanesthetized mice. Hear Res. 2018 Jun; 363:109-118. PMID: 29598837.
    View in: PubMed
  4. Gao X, Tao Y, Lamas V, Huang M, Yeh WH, Pan B, Hu YJ, Hu JH, Thompson DB, Shu Y, Li Y, Wang H, Yang S, Xu Q, Polley DB, Liberman MC, Kong WJ, Holt JR, Chen ZY, Liu DR. Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents. Nature. 2018 01 11; 553(7687):217-221. PMID: 29258297.
    View in: PubMed
  5. Valero MD, Burton JA, Hauser SN, Hackett TA, Ramachandran R, Liberman MC. Noise-induced cochlear synaptopathy in rhesus monkeys (Macaca mulatta). Hear Res. 2017 09; 353:213-223. PMID: 28712672.
    View in: PubMed
  6. Liberman MC. Noise-induced and age-related hearing loss:  new perspectives and potential therapies. F1000Res. 2017; 6:927. PMID: 28690836.
    View in: PubMed
  7. Suzuki J, Hashimoto K, Xiao R, Vandenberghe LH, Liberman MC. Corrigendum: Cochlear gene therapy with ancestral AAV in adult mice: complete transduction of inner hair cells without cochlear dysfunction. Sci Rep. 2017 05 22; 7:46827. PMID: 28530226.
    View in: PubMed
  8. Suzuki J, Hashimoto K, Xiao R, Vandenberghe LH, Liberman MC. Cochlear gene therapy with ancestral AAV in adult mice: complete transduction of inner hair cells without cochlear dysfunction. Sci Rep. 2017 04 03; 7:45524. PMID: 28367981.
    View in: PubMed
  9. Liberman MC, Kujawa SG. Cochlear synaptopathy in acquired sensorineural hearing loss: Manifestations and mechanisms. Hear Res. 2017 06; 349:138-147. PMID: 28087419.
    View in: PubMed
  10. Maison S, Liberman LD, Liberman MC. Type II Cochlear Ganglion Neurons Do Not Drive the Olivocochlear Reflex: Re-Examination of the Cochlear Phenotype in Peripherin Knock-Out Mice. eNeuro. 2016 Jul-Aug; 3(4). PMID: 27570826; PMCID: PMC4987660.
    View in: PubMed, PubMed Central
  11. Liberman LD, Liberman MC. Postnatal maturation of auditory-nerve heterogeneity, as seen in spatial gradients of synapse morphology in the inner hair cell area. Hear Res. 2016 09; 339:12-22. PMID: 27288592.
    View in: PubMed
  12. Mehraei G, Hickox AE, Bharadwaj HM, Goldberg H, Verhulst S, Liberman MC, Shinn-Cunningham BG. Auditory Brainstem Response Latency in Noise as a Marker of Cochlear Synaptopathy. J Neurosci. 2016 Mar 30; 36(13):3755-64. PMID: 27030760; PMCID: PMC4812134 [Available on 09/30/16].
    View in: PubMed, PubMed Central
  13. Maison SF, Yin Y, Liberman LD, Liberman MC. Perinatal thiamine deficiency causes cochlear innervation abnormalities in mice. Hear Res. 2016 05; 335:94-104. PMID: 26944177.
    View in: PubMed
  14. Chambers AR, Resnik J, Yuan Y, Whitton JP, Edge AS, Liberman MC, Polley DB. Central Gain Restores Auditory Processing following Near-Complete Cochlear Denervation. Neuron. 2016 Feb 17; 89(4):867-79. PMID: 26833137; PMCID: PMC4760846 [Available on 02/17/17].
    View in: PubMed, PubMed Central
  15. Valero MD, Hancock KE, Liberman MC. The middle ear muscle reflex in the diagnosis of cochlear neuropathy. Hear Res. 2016 Feb; 332:29-38. PMID: 26657094.
    View in: PubMed
  16. Liberman MC, Liberman LD, Maison SF. Chronic Conductive Hearing Loss Leads to Cochlear Degeneration. PLoS One. 2015; 10(11):e0142341. PMID: 26580411; PMCID: PMC4651495.
    View in: PubMed, PubMed Central
  17. Hickman TT, Liberman MC, Jacob MH. Adenomatous Polyposis Coli Protein Deletion in Efferent Olivocochlear Neurons Perturbs Afferent Synaptic Maturation and Reduces the Dynamic Range of Hearing. J Neurosci. 2015 Jun 17; 35(24):9236-45. PMID: 26085645.
    View in: PubMed
  18. Viana LM, O'Malley JT, Burgess BJ, Jones DD, Oliveira CA, Santos F, Merchant SN, Liberman LD, Liberman MC. Cochlear neuropathy in human presbycusis: Confocal analysis of hidden hearing loss in post-mortem tissue. Hear Res. 2015 Sep; 327:78-88. PMID: 26002688; PMCID: PMC4554812.
    View in: PubMed, PubMed Central
  19. Fernandez KA, Jeffers PW, Lall K, Liberman MC, Kujawa SG. Aging after noise exposure: acceleration of cochlear synaptopathy in "recovered" ears. J Neurosci. 2015 May 13; 35(19):7509-20. PMID: 25972177; PMCID: PMC4429155.
    View in: PubMed, PubMed Central
  20. Jensen JB, Lysaght AC, Liberman MC, Qvortrup K, Stankovic KM. Immediate and delayed cochlear neuropathy after noise exposure in pubescent mice. PLoS One. 2015; 10(5):e0125160. PMID: 25955832.
    View in: PubMed
  21. Liberman LD, Suzuki J, Liberman MC. Erratum to: dynamics of cochlear synaptopathy after acoustic overexposure. J Assoc Res Otolaryngol. 2015 Apr; 16(2):221. PMID: 25732849; PMCID: PMC4368651.
    View in: PubMed, PubMed Central
  22. Kujawa SG, Liberman MC. Synaptopathy in the noise-exposed and aging cochlea: Primary neural degeneration in acquired sensorineural hearing loss. Hear Res. 2015 Dec; 330(Pt B):191-9. PMID: 25769437; PMCID: PMC4567542 [Available on 12/01/16].
    View in: PubMed, PubMed Central
  23. Liberman LD, Suzuki J, Liberman MC. Dynamics of cochlear synaptopathy after acoustic overexposure. J Assoc Res Otolaryngol. 2015 Apr; 16(2):205-19. PMID: 25676132; PMCID: PMC4368657.
    View in: PubMed, PubMed Central
  24. Flores EN, Duggan A, Madathany T, Hogan AK, Márquez FG, Kumar G, Seal RP, Edwards RH, Liberman MC, García-Añoveros J. A non-canonical pathway from cochlea to brain signals tissue-damaging noise. Curr Biol. 2015 Mar 02; 25(5):606-12. PMID: 25639244; PMCID: PMC4348215.
    View in: PubMed, PubMed Central
  25. Liberman MC, Kujawa SG. Hot Topics-Hidden hearing loss: Permanent cochlear-nerve degeneration after temporary noise-induced threshold shift. J Acoust Soc Am. 2014 Apr; 135(4):2311. PMID: 25235676.
    View in: PubMed
  26. Liberman MC, Maison SF. Shelter from the Glutamate storm: Loss of olivocochlear efferents increases cochlear nerve degeneration during aging. J Acoust Soc Am. 2014 Apr; 135(4):2384. PMID: 25235936.
    View in: PubMed
  27. Liberman MC, Liberman LD, Maison SF. Efferent feedback slows cochlear aging. J Neurosci. 2014 Mar 26; 34(13):4599-607. PMID: 24672005; PMCID: PMC3965785.
    View in: PubMed, PubMed Central
  28. Yuan Y, Shi F, Yin Y, Tong M, Lang H, Polley DB, Liberman MC, Edge AS. Ouabain-induced cochlear nerve degeneration: synaptic loss and plasticity in a mouse model of auditory neuropathy. J Assoc Res Otolaryngol. 2014 Feb; 15(1):31-43. PMID: 24113829; PMCID: PMC3901858.
    View in: PubMed, PubMed Central
  29. Kantardzhieva A, Liberman MC, Sewell WF. Quantitative analysis of ribbons, vesicles, and cisterns at the cat inner hair cell synapse: correlations with spontaneous rate. J Comp Neurol. 2013 Oct 01; 521(14):3260-71. PMID: 23787810; PMCID: PMC4309284.
    View in: PubMed, PubMed Central
  30. Huang M, Kantardzhieva A, Scheffer D, Liberman MC, Chen ZY. Hair cell overexpression of Islet1 reduces age-related and noise-induced hearing loss. J Neurosci. 2013 Sep 18; 33(38):15086-94. PMID: 24048839; PMCID: PMC3776061.
    View in: PubMed, PubMed Central
  31. Sergeyenko Y, Lall K, Liberman MC, Kujawa SG. Age-related cochlear synaptopathy: an early-onset contributor to auditory functional decline. J Neurosci. 2013 Aug 21; 33(34):13686-94. PMID: 23966690; PMCID: PMC3755715.
    View in: PubMed, PubMed Central
  32. Furman AC, Kujawa SG, Liberman MC. Noise-induced cochlear neuropathy is selective for fibers with low spontaneous rates. J Neurophysiol. 2013 Aug; 110(3):577-86. PMID: 23596328; PMCID: PMC3742994.
    View in: PubMed, PubMed Central
  33. Maison SF, Usubuchi H, Liberman MC. Efferent feedback minimizes cochlear neuropathy from moderate noise exposure. J Neurosci. 2013 Mar 27; 33(13):5542-52. PMID: 23536069; PMCID: PMC3640841.
    View in: PubMed, PubMed Central
  34. Maison SF, Pyott SJ, Meredith AL, Liberman MC. Olivocochlear suppression of outer hair cells in vivo: evidence for combined action of BK and SK2 channels throughout the cochlea. J Neurophysiol. 2013 Mar; 109(6):1525-34. PMID: 23282326; PMCID: PMC3602942.
    View in: PubMed, PubMed Central
  35. McGinley MJ, Liberman MC, Bal R, Oertel D. Generating synchrony from the asynchronous: compensation for cochlear traveling wave delays by the dendrites of individual brainstem neurons. J Neurosci. 2012 Jul 04; 32(27):9301-11. PMID: 22764237; PMCID: PMC3417346.
    View in: PubMed, PubMed Central
  36. Maison SF, Usubuchi H, Vetter DE, Elgoyhen AB, Thomas SA, Liberman MC. Contralateral-noise effects on cochlear responses in anesthetized mice are dominated by feedback from an unknown pathway. J Neurophysiol. 2012 Jul; 108(2):491-500. PMID: 22514298; PMCID: PMC3404795.
    View in: PubMed, PubMed Central
  37. Zilberstein Y, Liberman MC, Corfas G. Inner hair cells are not required for survival of spiral ganglion neurons in the adult cochlea. J Neurosci. 2012 Jan 11; 32(2):405-10. PMID: 22238076; PMCID: PMC3678770.
    View in: PubMed, PubMed Central
  38. Maison SF, Liu XP, Eatock RA, Sibley DR, Grandy DK, Liberman MC. Dopaminergic signaling in the cochlea: receptor expression patterns and deletion phenotypes. J Neurosci. 2012 Jan 04; 32(1):344-55. PMID: 22219295; PMCID: PMC3313790.
    View in: PubMed, PubMed Central
  39. Chambers AR, Hancock KE, Maison SF, Liberman MC, Polley DB. Sound-evoked olivocochlear activation in unanesthetized mice. J Assoc Res Otolaryngol. 2012 Apr; 13(2):209-217. PMID: 22160753; PMCID: PMC3298614.
    View in: PubMed, PubMed Central
  40. Makary CA, Shin J, Kujawa SG, Liberman MC, Merchant SN. Age-related primary cochlear neuronal degeneration in human temporal bones. J Assoc Res Otolaryngol. 2011 Dec; 12(6):711-7. PMID: 21748533; PMCID: PMC3214241.
    View in: PubMed, PubMed Central
  41. Lin HW, Furman AC, Kujawa SG, Liberman MC. Primary neural degeneration in the Guinea pig cochlea after reversible noise-induced threshold shift. J Assoc Res Otolaryngol. 2011 Oct; 12(5):605-16. PMID: 21688060; PMCID: PMC3173555.
    View in: PubMed, PubMed Central
  42. Amatuzzi M, Liberman MC, Northrop C. Selective inner hair cell loss in prematurity: a temporal bone study of infants from a neonatal intensive care unit. J Assoc Res Otolaryngol. 2011 Oct; 12(5):595-604. PMID: 21674215; PMCID: PMC3173554.
    View in: PubMed, PubMed Central
  43. Irving S, Moore DR, Liberman MC, Sumner CJ. Olivocochlear efferent control in sound localization and experience-dependent learning. J Neurosci. 2011 Feb 16; 31(7):2493-501. PMID: 21325517; PMCID: PMC3292219.
    View in: PubMed, PubMed Central
  44. Liberman LD, Wang H, Liberman MC. Opposing gradients of ribbon size and AMPA receptor expression underlie sensitivity differences among cochlear-nerve/hair-cell synapses. J Neurosci. 2011 Jan 19; 31(3):801-8. PMID: 21248103; PMCID: PMC3290333.
    View in: PubMed, PubMed Central
  45. Jones SM, Robertson NG, Given S, Giersch AB, Liberman MC, Morton CC. Hearing and vestibular deficits in the Coch(-/-) null mouse model: comparison to the Coch(G88E/G88E) mouse and to DFNA9 hearing and balance disorder. Hear Res. 2011 Feb; 272(1-2):42-8. PMID: 21073934; PMCID: PMC3039082.
    View in: PubMed, PubMed Central
  46. Buran BN, Strenzke N, Neef A, Gundelfinger ED, Moser T, Liberman MC. Onset coding is degraded in auditory nerve fibers from mutant mice lacking synaptic ribbons. J Neurosci. 2010 Jun 02; 30(22):7587-97. PMID: 20519533; PMCID: PMC2901931.
    View in: PubMed, PubMed Central
  47. Yang J, Liu X, Zhao Y, Adamian M, Pawlyk B, Sun X, McMillan DR, Liberman MC, Li T. Ablation of whirlin long isoform disrupts the USH2 protein complex and causes vision and hearing loss. PLoS Genet. 2010 May 20; 6(5):e1000955. PMID: 20502675; PMCID: PMC2873905.
    View in: PubMed, PubMed Central
  48. Maison SF, Liu XP, Vetter DE, Eatock RA, Nathanson NM, Wess J, Liberman MC. Muscarinic signaling in the cochlea: presynaptic and postsynaptic effects on efferent feedback and afferent excitability. J Neurosci. 2010 May 12; 30(19):6751-62. PMID: 20463237; PMCID: PMC3332094.
    View in: PubMed, PubMed Central
  49. Larsen E, Liberman MC. Contralateral cochlear effects of ipsilateral damage: no evidence for interaural coupling. Hear Res. 2010 Feb; 260(1-2):70-80. PMID: 19944141; PMCID: PMC2815182.
    View in: PubMed, PubMed Central
  50. Kujawa SG, Liberman MC. Adding insult to injury: cochlear nerve degeneration after "temporary" noise-induced hearing loss. J Neurosci. 2009 Nov 11; 29(45):14077-85. PMID: 19906956; PMCID: PMC2812055.
    View in: PubMed, PubMed Central
  51. Liberman M, Mathisen DJ. Tailored cricoplasty: an improved modification for reconstruction in subglottic tracheal stenosis. J Thorac Cardiovasc Surg. 2009 Mar; 137(3):573-8; discussion 578-9. PMID: 19258068.
    View in: PubMed
  52. Larsen E, Liberman MC. Slow build-up of cochlear suppression during sustained contralateral noise: central modulation of olivocochlear efferents? Hear Res. 2009 Oct; 256(1-2):1-10. PMID: 19232534; PMCID: PMC2740808.
    View in: PubMed, PubMed Central
  53. Taranda J, Maison SF, Ballestero JA, Katz E, Savino J, Vetter DE, Boulter J, Liberman MC, Fuchs PA, Elgoyhen AB. A point mutation in the hair cell nicotinic cholinergic receptor prolongs cochlear inhibition and enhances noise protection. PLoS Biol. 2009 Jan 20; 7(1):e18. PMID: 19166271; PMCID: PMC2628405.
    View in: PubMed, PubMed Central
  54. Nehra D, Liberman M, Vagefi PA, Evans N, Inglessis I, Kradin RL, Ono J, Kanarek DJ, Gaissert HA. Complete pulmonary venous occlusion after radiofrequency ablation for atrial fibrillation. Ann Thorac Surg. 2009 Jan; 87(1):292-5. PMID: 19101316.
    View in: PubMed
  55. Maison SF, Casanova E, Holstein GR, Bettler B, Liberman MC. Loss of GABAB receptors in cochlear neurons: threshold elevation suggests modulation of outer hair cell function by type II afferent fibers. J Assoc Res Otolaryngol. 2009 Mar; 10(1):50-63. PMID: 18925381; PMCID: PMC2644393.
    View in: PubMed, PubMed Central
  56. Murthy V, Maison SF, Taranda J, Haque N, Bond CT, Elgoyhen AB, Adelman JP, Liberman MC, Vetter DE. SK2 channels are required for function and long-term survival of efferent synapses on mammalian outer hair cells. Mol Cell Neurosci. 2009 Jan; 40(1):39-49. PMID: 18848895; PMCID: PMC2661972.
    View in: PubMed, PubMed Central
  57. Robertson NG, Jones SM, Sivakumaran TA, Giersch AB, Jurado SA, Call LM, Miller CE, Maison SF, Liberman MC, Morton CC. A targeted Coch missense mutation: a knock-in mouse model for DFNA9 late-onset hearing loss and vestibular dysfunction. Hum Mol Genet. 2008 Nov 01; 17(21):3426-34. PMID: 18697796; PMCID: PMC2566528.
    View in: PubMed, PubMed Central
  58. Thiers FA, Nadol JB, Liberman MC. Reciprocal synapses between outer hair cells and their afferent terminals: evidence for a local neural network in the mammalian cochlea. J Assoc Res Otolaryngol. 2008 Dec; 9(4):477-89. PMID: 18688678; PMCID: PMC2580814.
    View in: PubMed, PubMed Central
  59. Depreux FF, Darrow K, Conner DA, Eavey RD, Liberman MC, Seidman CE, Seidman JG. Eya4-deficient mice are a model for heritable otitis media. J Clin Invest. 2008 Feb; 118(2):651-8. PMID: 18219393; PMCID: PMC2213371.
    View in: PubMed, PubMed Central
  60. Williamson RE, Darrow KN, Giersch AB, Resendes BL, Huang M, Conrad GW, Chen ZY, Liberman MC, Morton CC, Tasheva ES. Expression studies of osteoglycin/mimecan (OGN) in the cochlea and auditory phenotype of Ogn-deficient mice. Hear Res. 2008 Mar; 237(1-2):57-65. PMID: 18243607; PMCID: PMC2518649.
    View in: PubMed, PubMed Central
  61. Vetter DE, Katz E, Maison SF, Taranda J, Turcan S, Ballestero J, Liberman MC, Elgoyhen AB, Boulter J. The alpha10 nicotinic acetylcholine receptor subunit is required for normal synaptic function and integrity of the olivocochlear system. Proc Natl Acad Sci U S A. 2007 Dec 18; 104(51):20594-9. PMID: 18077337; PMCID: PMC2154476.
    View in: PubMed, PubMed Central
  62. Shi F, Corrales CE, Liberman MC, Edge AS. BMP4 induction of sensory neurons from human embryonic stem cells and reinnervation of sensory epithelium. Eur J Neurosci. 2007 Dec; 26(11):3016-23. PMID: 18005071.
    View in: PubMed
  63. Williamson RE, Darrow KN, Michaud S, Jacobs JS, Jones MC, Eberl DF, Maas RL, Liberman MC, Morton CC. Methylthioadenosine phosphorylase (MTAP) in hearing: gene disruption by chromosomal rearrangement in a hearing impaired individual and model organism analysis. Am J Med Genet A. 2007 Jul 15; 143A(14):1630-9. PMID: 17534888.
    View in: PubMed
  64. Gao J, Maison SF, Wu X, Hirose K, Jones SM, Bayazitov I, Tian Y, Mittleman G, Matthews DB, Zakharenko SS, Liberman MC, Zuo J. Orphan glutamate receptor delta1 subunit required for high-frequency hearing. Mol Cell Biol. 2007 Jun; 27(12):4500-12. PMID: 17438141; PMCID: PMC1900048.
    View in: PubMed, PubMed Central
  65. Maison SF, Vetter DE, Liberman MC. A novel effect of cochlear efferents: in vivo response enhancement does not require alpha9 cholinergic receptors. J Neurophysiol. 2007 May; 97(5):3269-78. PMID: 17344378.
    View in: PubMed
  66. Liu X, Bulgakov OV, Darrow KN, Pawlyk B, Adamian M, Liberman MC, Li T. Usherin is required for maintenance of retinal photoreceptors and normal development of cochlear hair cells. Proc Natl Acad Sci U S A. 2007 Mar 13; 104(11):4413-8. PMID: 17360538; PMCID: PMC1838616.
    View in: PubMed, PubMed Central
  67. Sugawara M, Murtie JC, Stankovic KM, Liberman MC, Corfas G. Dynamic patterns of neurotrophin 3 expression in the postnatal mouse inner ear. J Comp Neurol. 2007 Mar 01; 501(1):30-7. PMID: 17206617.
    View in: PubMed
  68. Maison SF, Parker LL, Young L, Adelman JP, Zuo J, Liberman MC. Overexpression of SK2 channels enhances efferent suppression of cochlear responses without enhancing noise resistance. J Neurophysiol. 2007 Apr; 97(4):2930-6. PMID: 17267753; PMCID: PMC1850627.
    View in: PubMed, PubMed Central
  69. Darrow KN, Maison SF, Liberman MC. Cochlear efferent feedback balances interaural sensitivity. Nat Neurosci. 2006 Dec; 9(12):1474-6. PMID: 17115038; PMCID: PMC1806686.
    View in: PubMed, PubMed Central
  70. Darrow KN, Maison SF, Liberman MC. Selective removal of lateral olivocochlear efferents increases vulnerability to acute acoustic injury. J Neurophysiol. 2007 Feb; 97(2):1775-85. PMID: 17093118; PMCID: PMC1805782.
    View in: PubMed, PubMed Central
  71. Corrales CE, Pan L, Li H, Liberman MC, Heller S, Edge AS. Engraftment and differentiation of embryonic stem cell-derived neural progenitor cells in the cochlear nerve trunk: growth of processes into the organ of Corti. J Neurobiol. 2006 Nov; 66(13):1489-500. PMID: 17013931; PMCID: PMC2040047.
    View in: PubMed, PubMed Central
  72. Maison SF, Rosahl TW, Homanics GE, Liberman MC. Functional role of GABAergic innervation of the cochlea: phenotypic analysis of mice lacking GABA(A) receptor subunits alpha 1, alpha 2, alpha 5, alpha 6, beta 2, beta 3, or delta. J Neurosci. 2006 Oct 04; 26(40):10315-26. PMID: 17021187; PMCID: PMC1806703.
    View in: PubMed, PubMed Central
  73. Darrow KN, Simons EJ, Dodds L, Liberman MC. Dopaminergic innervation of the mouse inner ear: evidence for a separate cytochemical group of cochlear efferent fibers. J Comp Neurol. 2006 Sep 20; 498(3):403-14. PMID: 16871528; PMCID: PMC1805779.
    View in: PubMed, PubMed Central
  74. Oliver D, Taberner AM, Thurm H, Sausbier M, Arntz C, Ruth P, Fakler B, Liberman MC. The role of BKCa channels in electrical signal encoding in the mammalian auditory periphery. J Neurosci. 2006 Jun 07; 26(23):6181-9. PMID: 16763026; PMCID: PMC1806704.
    View in: PubMed, PubMed Central
  75. Wang H, Northrop C, Burgess B, Liberman MC, Merchant SN. Three-dimensional virtual model of the human temporal bone: a stand-alone, downloadable teaching tool. Otol Neurotol. 2006 Jun; 27(4):452-7. PMID: 16791035; PMCID: PMC1805780.
    View in: PubMed, PubMed Central
  76. Liberman MC, Tartaglini E, Fleming JC, Neufeld EJ. Deletion of SLC19A2, the high affinity thiamine transporter, causes selective inner hair cell loss and an auditory neuropathy phenotype. J Assoc Res Otolaryngol. 2006 Sep; 7(3):211-7. PMID: 16642288; PMCID: PMC1805778.
    View in: PubMed, PubMed Central
  77. Kujawa SG, Liberman MC. Acceleration of age-related hearing loss by early noise exposure: evidence of a misspent youth. J Neurosci. 2006 Feb 15; 26(7):2115-23. PMID: 16481444; PMCID: PMC1855187.
    View in: PubMed, PubMed Central
  78. Robertson NG, Cremers CW, Huygen PL, Ikezono T, Krastins B, Kremer H, Kuo SF, Liberman MC, Merchant SN, Miller CE, Nadol JB, Sarracino DA, Verhagen WI, Morton CC. Cochlin immunostaining of inner ear pathologic deposits and proteomic analysis in DFNA9 deafness and vestibular dysfunction. Hum Mol Genet. 2006 Apr 01; 15(7):1071-85. PMID: 16481359.
    View in: PubMed
  79. Drottar M, Liberman MC, Ratan RR, Roberson DW. The histone deacetylase inhibitor sodium butyrate protects against cisplatin-induced hearing loss in guinea pigs. Laryngoscope. 2006 Feb; 116(2):292-6. PMID: 16467722; PMCID: PMC2570099.
    View in: PubMed, PubMed Central
  80. de Venecia RK, Liberman MC, Guinan JJ, Brown MC. Medial olivocochlear reflex interneurons are located in the posteroventral cochlear nucleus: a kainic acid lesion study in guinea pigs. J Comp Neurol. 2005 Jul 11; 487(4):345-60. PMID: 15906311; PMCID: PMC1815216.
    View in: PubMed, PubMed Central
  81. Sugawara M, Corfas G, Liberman MC. Influence of supporting cells on neuronal degeneration after hair cell loss. J Assoc Res Otolaryngol. 2005 Jun; 6(2):136-47. PMID: 15952050; PMCID: PMC2538335.
    View in: PubMed, PubMed Central
  82. Stankovic K, Rio C, Xia A, Sugawara M, Adams JC, Liberman MC, Corfas G. Survival of adult spiral ganglion neurons requires erbB receptor signaling in the inner ear. J Neurosci. 2004 Oct 06; 24(40):8651-61. PMID: 15470130.
    View in: PubMed
  83. Taberner AM, Liberman MC. Response properties of single auditory nerve fibers in the mouse. J Neurophysiol. 2005 Jan; 93(1):557-69. PMID: 15456804.
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  84. Liberman MC, Zuo J, Guinan JJ. Otoacoustic emissions without somatic motility: can stereocilia mechanics drive the mammalian cochlea? J Acoust Soc Am. 2004 Sep; 116(3):1649-55. PMID: 15478431; PMCID: PMC1805783.
    View in: PubMed, PubMed Central
  85. Groff JA, Liberman MC. Modulation of cochlear afferent response by the lateral olivocochlear system: activation via electrical stimulation of the inferior colliculus. J Neurophysiol. 2003 Nov; 90(5):3178-200. PMID: 14615429.
    View in: PubMed
  86. Hirose K, Liberman MC. Lateral wall histopathology and endocochlear potential in the noise-damaged mouse cochlea. J Assoc Res Otolaryngol. 2003 Sep; 4(3):339-52. PMID: 14690052; PMCID: PMC1805786.
    View in: PubMed, PubMed Central
  87. Maison SF, Emeson RB, Adams JC, Luebke AE, Liberman MC. Loss of alpha CGRP reduces sound-evoked activity in the cochlear nerve. J Neurophysiol. 2003 Nov; 90(5):2941-9. PMID: 12904337.
    View in: PubMed
  88. Shibusawa N, Hashimoto K, Nikrodhanond AA, Liberman MC, Applebury ML, Liao XH, Robbins JT, Refetoff S, Cohen RN, Wondisford FE. Thyroid hormone action in the absence of thyroid hormone receptor DNA-binding in vivo. J Clin Invest. 2003 Aug; 112(4):588-97. PMID: 12925699; PMCID: PMC171393.
    View in: PubMed, PubMed Central
  89. Maison SF, Adams JC, Liberman MC. Olivocochlear innervation in the mouse: immunocytochemical maps, crossed versus uncrossed contributions, and transmitter colocalization. J Comp Neurol. 2003 Jan 13; 455(3):406-16. PMID: 12483691; PMCID: PMC1805785.
    View in: PubMed, PubMed Central
  90. Maison SF, Luebke AE, Liberman MC, Zuo J. Efferent protection from acoustic injury is mediated via alpha9 nicotinic acetylcholine receptors on outer hair cells. J Neurosci. 2002 Dec 15; 22(24):10838-46. PMID: 12486177.
    View in: PubMed
  91. Liberman MC, Gao J, He DZ, Wu X, Jia S, Zuo J. Prestin is required for electromotility of the outer hair cell and for the cochlear amplifier. Nature. 2002 Sep 19; 419(6904):300-4. PMID: 12239568.
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  92. Vetter DE, Li C, Zhao L, Contarino A, Liberman MC, Smith GW, Marchuk Y, Koob GF, Heinemann SF, Vale W, Lee KF. Urocortin-deficient mice show hearing impairment and increased anxiety-like behavior. Nat Genet. 2002 Aug; 31(4):363-9. PMID: 12091910.
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  93. Wang Y, Liberman MC. Restraint stress and protection from acoustic injury in mice. Hear Res. 2002 Mar; 165(1-2):96-102. PMID: 12031519.
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  94. Wang Y, Hirose K, Liberman MC. Dynamics of noise-induced cellular injury and repair in the mouse cochlea. J Assoc Res Otolaryngol. 2002 Sep; 3(3):248-68. PMID: 12382101; PMCID: PMC3202415.
    View in: PubMed, PubMed Central
  95. Boyev KP, Liberman MC, Brown MC. Effects of anesthesia on efferent-mediated adaptation of the DPOAE. J Assoc Res Otolaryngol. 2002 Sep; 3(3):362-73. PMID: 12382109; PMCID: PMC3202411.
    View in: PubMed, PubMed Central
  96. Rio C, Dikkes P, Liberman MC, Corfas G. Glial fibrillary acidic protein expression and promoter activity in the inner ear of developing and adult mice. J Comp Neurol. 2002 Jan 07; 442(2):156-62. PMID: 11754168.
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  97. Bhatt KA, Liberman MC, Nadol JB. Morphometric analysis of age-related changes in the human basilar membrane. Ann Otol Rhinol Laryngol. 2001 Dec; 110(12):1147-53. PMID: 11768706.
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  98. Kujawa SG, Liberman MC. Effects of olivocochlear feedback on distortion product otoacoustic emissions in guinea pig. J Assoc Res Otolaryngol. 2001 Sep; 2(3):268-78. PMID: 11669399; PMCID: PMC3201675.
    View in: PubMed, PubMed Central
  99. Amatuzzi MG, Northrop C, Liberman MC, Thornton A, Halpin C, Herrmann B, Pinto LE, Saenz A, Carranza A, Eavey RD. Selective inner hair cell loss in premature infants and cochlea pathological patterns from neonatal intensive care unit autopsies. Arch Otolaryngol Head Neck Surg. 2001 Jun; 127(6):629-36. PMID: 11405860.
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  100. Hequembourg S, Liberman MC. Spiral ligament pathology: a major aspect of age-related cochlear degeneration in C57BL/6 mice. J Assoc Res Otolaryngol. 2001 Jun; 2(2):118-29. PMID: 11550522; PMCID: PMC3201181.
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  101. Yoshida N, Liberman MC, Brown MC, Sewell WF. Fast, but not slow, effects of olivocochlear activation are resistant to apamin. J Neurophysiol. 2001 Jan; 85(1):84-8. PMID: 11152708.
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  102. Yoshida N, Liberman MC. Sound conditioning reduces noise-induced permanent threshold shift in mice. Hear Res. 2000 Oct; 148(1-2):213-9. PMID: 10978838.
    View in: PubMed
  103. Liberman MC, O'Grady DF, Dodds LW, McGee J, Walsh EJ. Afferent innervation of outer and inner hair cells is normal in neonatally de-efferented cats. J Comp Neurol. 2000 Jul 17; 423(1):132-9. PMID: 10861542.
    View in: PubMed
  104. Maison SF, Liberman MC. Predicting vulnerability to acoustic injury with a noninvasive assay of olivocochlear reflex strength. J Neurosci. 2000 Jun 15; 20(12):4701-7. PMID: 10844039.
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  105. Yoshida N, Hequembourg SJ, Atencio CA, Rosowski JJ, Liberman MC. Acoustic injury in mice: 129/SvEv is exceptionally resistant to noise-induced hearing loss. Hear Res. 2000 03; 141(1-2):97-106. PMID: 10713498.
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  106. Yoshida N, Liberman MC, Brown MC, Sewell WF. Gentamicin blocks both fast and slow effects of olivocochlear activation in anesthetized guinea pigs. J Neurophysiol. 1999 Dec; 82(6):3168-74. PMID: 10601450.
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  107. Yoshida N, Kristiansen A, Liberman MC. Heat stress and protection from permanent acoustic injury in mice. J Neurosci. 1999 Nov 15; 19(22):10116-24. PMID: 10559419.
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  108. Abel ED, Boers ME, Pazos-Moura C, Moura E, Kaulbach H, Zakaria M, Lowell B, Radovick S, Liberman MC, Wondisford F. Divergent roles for thyroid hormone receptor beta isoforms in the endocrine axis and auditory system. J Clin Invest. 1999 Aug; 104(3):291-300. PMID: 10430610; PMCID: PMC408418.
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  109. Kujawa SG, Liberman MC. Long-term sound conditioning enhances cochlear sensitivity. J Neurophysiol. 1999 Aug; 82(2):863-73. PMID: 10444683.
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  110. Vetter DE, Liberman MC, Mann J, Barhanin J, Boulter J, Brown MC, Saffiote-Kolman J, Heinemann SF, Elgoyhen AB. Role of alpha9 nicotinic ACh receptor subunits in the development and function of cochlear efferent innervation. Neuron. 1999 May; 23(1):93-103. PMID: 10402196.
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  111. Yoshida N, Liberman MC. Stereociliary anomaly in the guinea pig: effects of hair bundle rotation on cochlear sensitivity. Hear Res. 1999 May; 131(1-2):29-38. PMID: 10355602.
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  112. Liberman MC, Guinan JJ. Feedback control of the auditory periphery: anti-masking effects of middle ear muscles vs. olivocochlear efferents. J Commun Disord. 1998 Nov-Dec; 31(6):471-82; quiz 483; 553. PMID: 9836136.
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  113. Fechner FP, Burgess BJ, Adams JC, Liberman MC, Nadol JB. Dense innervation of Deiters' and Hensen's cells persists after chronic deefferentation of guinea pig cochleas. J Comp Neurol. 1998 Oct 26; 400(3):299-309. PMID: 9779936.
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  114. Brown MC, Kujawa SG, Liberman MC. Single olivocochlear neurons in the guinea pig. II. Response plasticity due to noise conditioning. J Neurophysiol. 1998 Jun; 79(6):3088-97. PMID: 9636110.
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  115. Walsh EJ, McGee J, McFadden SL, Liberman MC. Long-term effects of sectioning the olivocochlear bundle in neonatal cats. J Neurosci. 1998 May 15; 18(10):3859-69. PMID: 9570815.
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  116. Kujawa SG, Liberman MC. Conditioning-related protection from acoustic injury: effects of chronic deefferentation and sham surgery. J Neurophysiol. 1997 Dec; 78(6):3095-106. PMID: 9405529.
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  117. Tsuji J, Liberman MC. Intracellular labeling of auditory nerve fibers in guinea pig: central and peripheral projections. J Comp Neurol. 1997 May 05; 381(2):188-202. PMID: 9130668.
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  118. Satake M, Liberman MC. Morphological subclasses of lateral olivocochlear terminals? Ultrastructural analysis of inner spiral bundle in cat and guinea pig. J Comp Neurol. 1996 Aug 05; 371(4):621-32. PMID: 8841914.
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  119. Merchan-Perez A, Liberman MC. Ultrastructural differences among afferent synapses on cochlear hair cells: correlations with spontaneous discharge rate. J Comp Neurol. 1996 Jul 22; 371(2):208-21. PMID: 8835727.
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  120. Liberman MC, Puria S, Guinan JJ. The ipsilaterally evoked olivocochlear reflex causes rapid adaptation of the 2f1-f2 distortion product otoacoustic emission. J Acoust Soc Am. 1996 Jun; 99(6):3572-84. PMID: 8655789.
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  121. Puria S, Guinan JJ, Liberman MC. Olivocochlear reflex assays: effects of contralateral sound on compound action potentials versus ear-canal distortion products. J Acoust Soc Am. 1996 Jan; 99(1):500-7. PMID: 8568037.
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  122. Liberman MC, Gao WY. Chronic cochlear de-efferentation and susceptibility to permanent acoustic injury. Hear Res. 1995 Oct; 90(1-2):158-68. PMID: 8974993.
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  123. Sridhar TS, Liberman MC, Brown MC, Sewell WF. A novel cholinergic "slow effect" of efferent stimulation on cochlear potentials in the guinea pig. J Neurosci. 1995 May; 15(5 Pt 1):3667-78. PMID: 7751937.
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  124. Reiter ER, Liberman MC. Efferent-mediated protection from acoustic overexposure: relation to slow effects of olivocochlear stimulation. J Neurophysiol. 1995 Feb; 73(2):506-14. PMID: 7760114.
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  125. Kawase T, Liberman MC. Antimasking effects of the olivocochlear reflex. I. Enhancement of compound action potentials to masked tones. J Neurophysiol. 1993 Dec; 70(6):2519-32. PMID: 8120596.
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  126. Kawase T, Delgutte B, Liberman MC. Antimasking effects of the olivocochlear reflex. II. Enhancement of auditory-nerve response to masked tones. J Neurophysiol. 1993 Dec; 70(6):2533-49. PMID: 8120597.
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  127. Liberman MC. Central projections of auditory nerve fibers of differing spontaneous rate, II: Posteroventral and dorsal cochlear nuclei. J Comp Neurol. 1993 Jan 01; 327(1):17-36. PMID: 8432906.
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  128. Kawase T, Liberman MC. Spatial organization of the auditory nerve according to spontaneous discharge rate. J Comp Neurol. 1992 May 08; 319(2):312-8. PMID: 1381729.
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  129. Liberman MC. Central projections of auditory-nerve fibers of differing spontaneous rate. I. Anteroventral cochlear nucleus. J Comp Neurol. 1991 Nov 08; 313(2):240-58. PMID: 1722487.
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  130. Liberman MC. The olivocochlear efferent bundle and susceptibility of the inner ear to acoustic injury. J Neurophysiol. 1991 Jan; 65(1):123-32. PMID: 1999726.
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  131. Liberman MC, Dodds LW, Pierce S. Afferent and efferent innervation of the cat cochlea: quantitative analysis with light and electron microscopy. J Comp Neurol. 1990 Nov 15; 301(3):443-60. PMID: 2262601.
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  132. Liberman MC. Effects of chronic cochlear de-efferentation on auditory-nerve response. Hear Res. 1990 Nov; 49(1-3):209-23. PMID: 1705540.
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  133. Liberman MC. Quantitative assessment of inner ear pathology following ototoxic drugs or acoustic trauma. Toxicol Pathol. 1990; 18(1 Pt 2):138-48. PMID: 2195634.
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  134. Liberman MC. Rapid assessment of sound-evoked olivocochlear feedback: suppression of compound action potentials by contralateral sound. Hear Res. 1989 Mar; 38(1-2):47-56. PMID: 2708159.
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  135. Warren EH, Liberman MC. Effects of contralateral sound on auditory-nerve responses. I. Contributions of cochlear efferents. Hear Res. 1989 Jan; 37(2):89-104. PMID: 2914811.
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  136. Warren EH, Liberman MC. Effects of contralateral sound on auditory-nerve responses. II. Dependence on stimulus variables. Hear Res. 1989 Jan; 37(2):105-21. PMID: 2914807.
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  137. Brown MC, Liberman MC, Benson TE, Ryugo DK. Brainstem branches from olivocochlear axons in cats and rodents. J Comp Neurol. 1988 Dec 22; 278(4):591-603. PMID: 3230172.
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  138. Liberman MC. Response properties of cochlear efferent neurons: monaural vs. binaural stimulation and the effects of noise. J Neurophysiol. 1988 Nov; 60(5):1779-98. PMID: 3199181.
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  139. Liberman MC. Physiology of cochlear efferent and afferent neurons: direct comparisons in the same animal. Hear Res. 1988 Jul 15; 34(2):179-91. PMID: 3170360.
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  140. Simmons DD, Liberman MC. Afferent innervation of outer hair cells in adult cats: I. Light microscopic analysis of fibers labeled with horseradish peroxidase. J Comp Neurol. 1988 Apr 01; 270(1):132-44. PMID: 3372735.
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  141. Simmons DD, Liberman MC. Afferent innervation of outer hair cells in adult cats: II. Electron microscopic analysis of fibers labeled with horseradish peroxidase. J Comp Neurol. 1988 Apr 01; 270(1):145-54. PMID: 3372736.
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  142. Liberman MC, Dodds LW. Acute ultrastructural changes in acoustic trauma: serial-section reconstruction of stereocilia and cuticular plates. Hear Res. 1987; 26(1):45-64. PMID: 3558143.
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  143. Liberman MC. Chronic ultrastructural changes in acoustic trauma: serial-section reconstruction of stereocilia and cuticular plates. Hear Res. 1987; 26(1):65-88. PMID: 3558144.
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  144. Liberman MC, Brown MC. Physiology and anatomy of single olivocochlear neurons in the cat. Hear Res. 1986; 24(1):17-36. PMID: 3759672.
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  145. Kiang NY, Liberman MC, Sewell WF, Guinan JJ. Single unit clues to cochlear mechanisms. Hear Res. 1986; 22:171-82. PMID: 3733538.
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  146. Liberman MC, Simmons DD. Applications of neuronal labeling techniques to the study of the peripheral auditory system. J Acoust Soc Am. 1985 Jul; 78(1 Pt 2):312-9. PMID: 4031239.
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  147. Fekete DM, Rouiller EM, Liberman MC, Ryugo DK. The central projections of intracellularly labeled auditory nerve fibers in cats. J Comp Neurol. 1984 Nov 01; 229(3):432-50. PMID: 6209306.
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  148. Liberman MC. Single-neuron labeling and chronic cochlear pathology. I. Threshold shift and characteristic-frequency shift. Hear Res. 1984 Oct; 16(1):33-41. PMID: 6096345.
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  149. Liberman MC, Kiang NY. Single-neuron labeling and chronic cochlear pathology. IV. Stereocilia damage and alterations in rate- and phase-level functions. Hear Res. 1984 Oct; 16(1):75-90. PMID: 6511674.
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  150. Liberman MC, Dodds LW. Single-neuron labeling and chronic cochlear pathology. III. Stereocilia damage and alterations of threshold tuning curves. Hear Res. 1984 Oct; 16(1):55-74. PMID: 6511673.
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  151. Liberman MC, Dodds LW. Single-neuron labeling and chronic cochlear pathology. II. Stereocilia damage and alterations of spontaneous discharge rates. Hear Res. 1984 Oct; 16(1):43-53. PMID: 6511672.
    View in: PubMed
  152. Pettigrew AM, Liberman MC, Kiang NY. Click-evoked gross potentials and single-unit thresholds in acoustically traumatized cats. Ann Otol Rhinol Laryngol Suppl. 1984 Jul-Aug; 112:83-96. PMID: 6431888.
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  153. Liberman MC, Oliver ME. Morphometry of intracellularly labeled neurons of the auditory nerve: correlations with functional properties. J Comp Neurol. 1984 Feb 20; 223(2):163-76. PMID: 6200517.
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  154. Kiang NY, Keithley EM, Liberman MC. The impact of auditory nerve experiments on cochlear implant design. Ann N Y Acad Sci. 1983; 405:114-21. PMID: 6575637.
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  155. Liberman MC. The cochlear frequency map for the cat: labeling auditory-nerve fibers of known characteristic frequency. J Acoust Soc Am. 1982 Nov; 72(5):1441-9. PMID: 7175031.
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  156. Kiang NY, Rho JM, Northrop CC, Liberman MC, Ryugo DK. Hair-cell innervation by spiral ganglion cells in adult cats. Science. 1982 Jul 09; 217(4555):175-7. PMID: 7089553.
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  157. Liberman MC. Single-neuron labeling in the cat auditory nerve. Science. 1982 Jun 11; 216(4551):1239-41. PMID: 7079757.
    View in: PubMed
  158. Liberman MC. Efferent synapses in the inner hair cell area of the cat cochlea: an electron microscopic study of serial sections. Hear Res. 1980 Oct; 3(3):189-204. PMID: 7440423.
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  159. Liberman MC. Morphological differences among radial afferent fibers in the cat cochlea: an electron-microscopic study of serial sections. Hear Res. 1980 Jul; 3(1):45-63. PMID: 7400048.
    View in: PubMed
  160. Liberman MC, Beil DG. Hair cell condition and auditory nerve response in normal and noise-damaged cochleas. Acta Otolaryngol. 1979; 88(3-4):161-76. PMID: 495068.
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  161. Liberman MC. Auditory-nerve response from cats raised in a low-noise chamber. J Acoust Soc Am. 1978 Feb; 63(2):442-55. PMID: 670542.
    View in: PubMed
  162. Liberman MC, Kiang NY. Acoustic trauma in cats. Cochlear pathology and auditory-nerve activity. Acta Otolaryngol Suppl. 1978; 358:1-63. PMID: 281107.
    View in: PubMed
  163. Kiang NY, Liberman MC, Levine RA. Auditory-nerve activity in cats exposed to ototoxic drugs and high-intensity sounds. Ann Otol Rhinol Laryngol. 1976 Nov-Dec; 85(6 PT. 1):752-68. PMID: 999140.
    View in: PubMed
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