Harvard Catalyst Profiles

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William Waiman Chin, M.D.

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Mentoring
Optimizing the Role of Academia in Regulatory Science
Summer, 07/02/12 - 08/24/12

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01DK054343 (MAAS, RICHARD L) Sep 15, 1998 - Jul 31, 2002
    NIH/NIDDK
    THYROID HORMONE ACTION IN NEUROGENESIS
    Role: Co-Principal Investigator
  2. R01DK050300 (CHIN, WILLIAM W.) Sep 1, 1995 - Aug 31, 2000
    NIH/NIDDK
    MECHANISMS OF NUCLEAR THYROID HORMONE ACTION
    Role: Principal Investigator
  3. K12DK001401 (BRENNER, BARRY M) Jul 1, 1985 - Jun 30, 1992
    NIH/NIDDK
    PHYSICIAN SCIENTIST PROGRAM AWARD
    Role: Co-Principal Investigator
  4. R01HD019938 (KAISER, URSULA B) Aug 1, 1984 - Oct 31, 2009
    NIH/NICHD
    Reproductive Physiology of Gonadotropin Synthesis
    Role: Co-Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Yu L, Iwasaki T, Xu M, Lesmana R, Xiong Y, Shimokawa N, Chin WW, Koibuchi N. Aberrant cerebellar development of transgenic mice expressing dominant-negative thyroid hormone receptor in cerebellar Purkinje cells. Endocrinology. 2015 Apr; 156(4):1565-76. PMID: 25603044.
    Citations: 7     Fields:    Translation:AnimalsCells
  2. Munos BH, Chin WW. How to revive breakthrough innovation in the pharmaceutical industry. Sci Transl Med. 2011 Jun 29; 3(89):89cm16. PMID: 21715677.
    Citations: 15     Fields:    Translation:Humans
  3. Na S, Ma Y, Zhao J, Schmidt C, Zeng QQ, Chandrasekhar S, Chin WW, Nagpal S. A Nonsecosteroidal Vitamin D Receptor Modulator Ameliorates Experimental Autoimmune Encephalomyelitis without Causing Hypercalcemia. Autoimmune Dis. 2011 Jan 26; 2011:132958. PMID: 21318047.
    Citations: 4     
  4. Lee LS, Thong PS, Olivo M, Chin WW, Ramaswamy B, Kho KW, Lim PL, Lau WK. Chlorin e6-polyvinylpyrrolidone mediated photodynamic therapy--A potential bladder sparing option for high risk non-muscle invasive bladder cancer. Photodiagnosis Photodyn Ther. 2010 Dec; 7(4):213-20. PMID: 21112542.
    Citations: 5     Fields:    Translation:Humans
  5. Chin WW, Praveen T, Heng PW, Olivo M. Effect of polyvinylpyrrolidone on the interaction of chlorin e6 with plasma proteins and its subcellular localization. Eur J Pharm Biopharm. 2010 Oct; 76(2):245-52. PMID: 20558287.
    Citations:    Fields:    Translation:HumansAnimalsCells
  6. Munos BH, Chin WW. A call for sharing: adapting pharmaceutical research to new realities. Sci Transl Med. 2009 Dec 02; 1(9):9cm8. PMID: 20368187.
    Citations: 7     Fields:    
  7. Thong PS, Olivo M, Chin WW, Bhuvaneswari R, Mancer K, Soo KC. Clinical application of fluorescence endoscopic imaging using hypericin for the diagnosis of human oral cavity lesions. Br J Cancer. 2009 Nov 03; 101(9):1580-4. PMID: 19809432.
    Citations: 4     Fields:    Translation:Humans
  8. Chin WW, Thong PS, Bhuvaneswari R, Soo KC, Heng PW, Olivo M. In-vivo optical detection of cancer using chlorin e6--polyvinylpyrrolidone induced fluorescence imaging and spectroscopy. BMC Med Imaging. 2009 Jan 08; 9:1. PMID: 19133127.
    Citations: 3     Fields:    Translation:AnimalsCells
  9. Chin WW, Heng PW, Lim PL, Lau WK, Olivo M. Membrane transport enhancement of chlorin e6-polyvinylpyrrolidone and its photodynamic efficacy on the chick chorioallantoic model. J Biophotonics. 2008 Oct; 1(5):395-407. PMID: 19343663.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  10. Bhuvaneswari R, Gan YY, Lucky SS, Chin WW, Ali SM, Soo KC, Olivo M. Molecular profiling of angiogenesis in hypericin mediated photodynamic therapy. Mol Cancer. 2008 Jun 13; 7:56. PMID: 18549507.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  11. Chin WW, Heng PW, Thong PS, Bhuvaneswari R, Hirt W, Kuenzel S, Soo KC, Olivo M. Improved formulation of photosensitizer chlorin e6 polyvinylpyrrolidone for fluorescence diagnostic imaging and photodynamic therapy of human cancer. Eur J Pharm Biopharm. 2008 Aug; 69(3):1083-93. PMID: 18396019.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  12. Thong PS, Olivo M, Kho KW, Bhuvaneswari R, Chin WW, Ong KW, Soo KC. Immune response against angiosarcoma following lower fluence rate clinical photodynamic therapy. J Environ Pathol Toxicol Oncol. 2008; 27(1):35-42. PMID: 18551894.
    Citations: 10     Fields:    Translation:Humans
  13. Chin WW, Heng PW, Olivo M. Chlorin e6 - polyvinylpyrrolidone mediated photosensitization is effective against human non-small cell lung carcinoma compared to small cell lung carcinoma xenografts. BMC Pharmacol. 2007 Dec 01; 7:15. PMID: 18053148.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  14. Fu CY, Ng BK, Razul SG, Chin WW, Tan PH, Lau WK, Olivo M. Fluorescence detection of bladder cancer using urine cytology. Int J Oncol. 2007 Sep; 31(3):525-30. PMID: 17671678.
    Citations: 3     Fields:    Translation:Humans
  15. Saw CL, Olivo M, Chin WW, Soo KC, Heng PW. Superiority of N-methyl pyrrolidone over albumin with hypericin for fluorescence diagnosis of human bladder cancer cells implanted in the chick chorioallantoic membrane model. J Photochem Photobiol B. 2007 Mar 01; 86(3):207-18. PMID: 17134910.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  16. Chin WW, Heng PW, Bhuvaneswari R, Lau WK, Olivo M. The potential application of chlorin e6-polyvinylpyrrolidone formulation in photodynamic therapy. Photochem Photobiol Sci. 2006 Nov; 5(11):1031-7. PMID: 17077899.
    Citations: 7     Fields:    Translation:Animals
  17. Chin WW, Lau WK, Heng PW, Bhuvaneswari R, Olivo M. Fluorescence imaging and phototoxicity effects of new formulation of chlorin e6-polyvinylpyrrolidone. J Photochem Photobiol B. 2006 Aug 01; 84(2):103-10. PMID: 16542848.
    Citations: 9     Fields:    Translation:Animals
  18. Ma Y, Khalifa B, Yee YK, Lu J, Memezawa A, Savkur RS, Yamamoto Y, Chintalacharuvu SR, Yamaoka K, Stayrook KR, Bramlett KS, Zeng QQ, Chandrasekhar S, Yu XP, Linebarger JH, Iturria SJ, Burris TP, Kato S, Chin WW, Nagpal S. Identification and characterization of noncalcemic, tissue-selective, nonsecosteroidal vitamin D receptor modulators. J Clin Invest. 2006 Apr; 116(4):892-904. PMID: 16528410.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  19. Chin WW, Lau WK, Bhuvaneswari R, Heng PW, Olivo M. Chlorin e6-polyvinylpyrrolidone as a fluorescent marker for fluorescence diagnosis of human bladder cancer implanted on the chick chorioallantoic membrane model. Cancer Lett. 2007 Jan 08; 245(1-2):127-33. PMID: 16516376.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  20. Olivo M, Chin W. Perylenequinones in photodynamic therapy: cellular versus vascular response. J Environ Pathol Toxicol Oncol. 2006; 25(1-2):223-37. PMID: 16566720.
    Citations: 8     Fields:    Translation:HumansAnimals
  21. Iwasaki T, Takeshita A, Miyazaki W, Chin WW, Koibuchi N. The interaction of TRbeta1-N terminus with steroid receptor coactivator-1 (SRC-1) serves a full transcriptional activation function of SRC-1. Endocrinology. 2006 Mar; 147(3):1452-7. PMID: 16357047.
    Citations:    Fields:    Translation:AnimalsCells
  22. Perry WL, Shepard RL, Sampath J, Yaden B, Chin WW, Iversen PW, Jin S, Lesoon A, O'Brien KA, Peek VL, Rolfe M, Shyjan A, Tighe M, Williamson M, Krishnan V, Moore RE, Dantzig AH. Human splicing factor SPF45 (RBM17) confers broad multidrug resistance to anticancer drugs when overexpressed--a phenotype partially reversed by selective estrogen receptor modulators. Cancer Res. 2005 Aug 01; 65(15):6593-600. PMID: 16061639.
    Citations: 9     Fields:    Translation:HumansCells
  23. Saw CL, Heng PW, Chin WW, Soo KC, Olivo M. Enhanced photodynamic activity of hypericin by penetration enhancer N-methyl pyrrolidone formulations in the chick chorioallantoic membrane model. Cancer Lett. 2006 Jul 08; 238(1):104-10. PMID: 16054752.
    Citations: 1     Fields:    Translation:AnimalsCells
  24. Ramaswamy B, Manivasager V, Chin WW, Soo KC, Olivo M. Photodynamic diagnosis of a human nasopharyngeal carcinoma xenograft model using the novel Chlorin e6 photosensitizer Fotolon. Int J Oncol. 2005 Jun; 26(6):1501-6. PMID: 15870862.
    Citations: 2     Fields:    Translation:HumansAnimals
  25. Saw CL, Olivo M, Chin WW, Soo KC, Heng PW. Transport of hypericin across chick chorioallantoic membrane and photodynamic therapy vasculature assessment. Biol Pharm Bull. 2005 Jun; 28(6):1054-60. PMID: 15930744.
    Citations: 2     Fields:    Translation:Animals
  26. Gray SG, Iglesias AH, Lizcano F, Villanueva R, Camelo S, Jingu H, Teh BT, Koibuchi N, Chin WW, Kokkotou E, Dangond F. Functional characterization of JMJD2A, a histone deacetylase- and retinoblastoma-binding protein. J Biol Chem. 2005 Aug 05; 280(31):28507-18. PMID: 15927959.
    Citations: 43     Fields:    Translation:HumansCells
  27. Iwasaki T, Koibuchi N, Chin WW. Synovial sarcoma translocation (SYT) encodes a nuclear receptor coactivator. Endocrinology. 2005 Sep; 146(9):3892-9. PMID: 15919756.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  28. Vasudevan N, Kia HK, Hadjimarkou M, Koibuchi N, Chin WW, Forrest D, Vennstrom B, Pfaff D. Retinoid-related receptor (ROR) alpha mRNA expression is altered in the brain of male mice lacking all ligand-binding thyroid hormone receptor (TR) isoforms. Endocrine. 2005 Feb; 26(1):25-32. PMID: 15805582.
    Citations: 1     Fields:    Translation:Animals
  29. Chin W, Lau W, Lay SL, Wei KK, Olivo M. Photodynamic-induced vascular damage of the chick chorioallantoic membrane model using perylenequinones. Int J Oncol. 2004 Oct; 25(4):887-91. PMID: 15375536.
    Citations: 1     Fields:    Translation:Animals
  30. Chin W, Lau W, Cheng C, Olivo M. Evaluation of Hypocrellin B in a human bladder tumor model in experimental photodynamic therapy: biodistribution, light dose and drug-light interval effects. Int J Oncol. 2004 Sep; 25(3):623-9. PMID: 15289863.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  31. Jeong KH, Chin WW, Kaiser UB. Essential role of the homeodomain for pituitary homeobox 1 activation of mouse gonadotropin-releasing hormone receptor gene expression through interactions with c-Jun and DNA. Mol Cell Biol. 2004 Jul; 24(14):6127-39. PMID: 15226417.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  32. Bettoun DJ, Lu J, Khalifa B, Yee Y, Chin WW, Nagpal S. Ligand modulates VDR-Ser/Thr protein phosphatase interaction and p70S6 kinase phosphorylation in a cell-context-dependent manner. J Steroid Biochem Mol Biol. 2004 May; 89-90(1-5):195-8. PMID: 15225771.
    Citations: 4     Fields:    Translation:HumansCells
  33. Bettoun DJ, Burris TP, Houck KA, Buck DW, Stayrook KR, Khalifa B, Lu J, Chin WW, Nagpal S. Retinoid X receptor is a nonsilent major contributor to vitamin D receptor-mediated transcriptional activation. Mol Endocrinol. 2003 Nov; 17(11):2320-8. PMID: 12893883.
    Citations: 21     Fields:    Translation:HumansCells
  34. Draper MW, Chin WW. Molecular and clinical evidence for the unique nature of individual selective estrogen receptor modulators. Clin Obstet Gynecol. 2003 Jun; 46(2):265-97. PMID: 12808380.
    Citations:    Fields:    Translation:Humans
  35. Ko L, Chin WW. Nuclear receptor coactivator thyroid hormone receptor-binding protein (TRBP) interacts with and stimulates its associated DNA-dependent protein kinase. J Biol Chem. 2003 Mar 28; 278(13):11471-9. PMID: 12519782.
    Citations: 7     Fields:    Translation:HumansCells
  36. Koibuchi N, Jingu H, Iwasaki T, Chin WW. Current perspectives on the role of thyroid hormone in growth and development of cerebellum. Cerebellum. 2003; 2(4):279-89. PMID: 14964687.
    Citations: 17     Fields:    Translation:HumansAnimals
  37. Wu Y, Chin WW, Wang Y, Burris TP. Ligand and coactivator identity determines the requirement of the charge clamp for coactivation of the peroxisome proliferator-activated receptor gamma. J Biol Chem. 2003 Mar 07; 278(10):8637-44. PMID: 12502716.
    Citations: 14     Fields:    Translation:HumansCells
  38. Thomas J, Bramlett KS, Montrose C, Foxworthy P, Eacho PI, McCann D, Cao G, Kiefer A, McCowan J, Yu KL, Grese T, Chin WW, Burris TP, Michael LF. A chemical switch regulates fibrate specificity for peroxisome proliferator-activated receptor alpha (PPARalpha ) versus liver X receptor. J Biol Chem. 2003 Jan 24; 278(4):2403-10. PMID: 12441342.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  39. Delerive P, Chin WW, Suen CS. Identification of Reverb(alpha) as a novel ROR(alpha) target gene. J Biol Chem. 2002 Sep 20; 277(38):35013-8. PMID: 12114512.
    Citations: 26     Fields:    Translation:AnimalsCells
  40. Bettoun DJ, Buck DW, Lu J, Khalifa B, Chin WW, Nagpal S. A vitamin D receptor-Ser/Thr phosphatase-p70 S6 kinase complex and modulation of its enzymatic activities by the ligand. J Biol Chem. 2002 Jul 12; 277(28):24847-50. PMID: 12036952.
    Citations: 9     Fields:    Translation:HumansCells
  41. Norwitz ER, Xu S, Jeong KH, Bédécarrats GY, Winebrenner LD, Chin WW, Kaiser UB. Activin A augments GnRH-mediated transcriptional activation of the mouse GnRH receptor gene. Endocrinology. 2002 Mar; 143(3):985-97. PMID: 11861523.
    Citations: 18     Fields:    Translation:AnimalsCells
  42. Norwitz ER, Xu S, Jeong KH, Be de Carrats GG, Winebrenner LD, Chin WW, Kaiser UB. Activin A Augments GnRH-Mediated Transcriptional Activation of the Mouse GnRH Receptor Gene. Endocrinology. 2002 Mar 01; 143(3):985-997. PMID: 28204468.
    Citations:    
  43. Ko L, Cardona GR, Henrion-Caude A, Chin WW. Identification and characterization of a tissue-specific coactivator, GT198, that interacts with the DNA-binding domains of nuclear receptors. Mol Cell Biol. 2002 Jan; 22(1):357-69. PMID: 11739747.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  44. Ko L, Cardona GR, Iwasaki T, Bramlett KS, Burris TP, Chin WW. Ser-884 adjacent to the LXXLL motif of coactivator TRBP defines selectivity for ERs and TRs. Mol Endocrinol. 2002 Jan; 16(1):128-40. PMID: 11773444.
    Citations: 11     Fields:    Translation:AnimalsCells
  45. Wu Y, Delerive P, Chin WW, Burris TP. Requirement of helix 1 and the AF-2 domain of the thyroid hormone receptor for coactivation by PGC-1. J Biol Chem. 2002 Mar 15; 277(11):8898-905. PMID: 11751919.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  46. Delerive P, Wu Y, Burris TP, Chin WW, Suen CS. PGC-1 functions as a transcriptional coactivator for the retinoid X receptors. J Biol Chem. 2002 Feb 08; 277(6):3913-7. PMID: 11714715.
    Citations: 19     Fields:    Translation:HumansCells
  47. Vasudevan N, Koibuchi N, Chin WW, Pfaff DW. Differential crosstalk between estrogen receptor (ER)alpha and ERbeta and the thyroid hormone receptor isoforms results in flexible regulation of the consensus ERE. Brain Res Mol Brain Res. 2001 Nov 01; 95(1-2):9-17. PMID: 11687272.
    Citations: 15     Fields:    Translation:AnimalsCells
  48. Vasudevan N, Davidkova G, Zhu YS, Koibuchi N, Chin WW, Pfaff D. Differential interaction of estrogen receptor and thyroid hormone receptor isoforms on the rat oxytocin receptor promoter leads to differences in transcriptional regulation. Neuroendocrinology. 2001 Nov; 74(5):309-24. PMID: 11694763.
    Citations: 14     Fields:    Translation:AnimalsCells
  49. Chin WW. Message from the president of the American Thyroid Association. Thyroid. 2001 Sep; 11(9):811. PMID: 11575848.
    Citations:    Fields:    
  50. Vasudevan N, Zhu YS, Daniel S, Koibuchi N, Chin WW, Pfaff D. Crosstalk between oestrogen receptors and thyroid hormone receptor isoforms results in differential regulation of the preproenkephalin gene. J Neuroendocrinol. 2001 Sep; 13(9):779-90. PMID: 11578528.
    Citations: 11     Fields:    Translation:AnimalsCells
  51. Kia HK, Krebs CJ, Koibuchi N, Chin WW, Pfaff DW. Co-expression of estrogen and thyroid hormone receptors in individual hypothalamic neurons. J Comp Neurol. 2001 Aug 27; 437(3):286-95. PMID: 11494256.
    Citations: 1     Fields:    Translation:AnimalsCells
  52. Zhu YS, Cai LQ, You X, Duan Y, Imperato-McGinley J, Chin WW, Pfaff DW. Molecular analysis of estrogen induction of preproenkephalin gene expression and its modulation by thyroid hormones. Brain Res Mol Brain Res. 2001 Jul 13; 91(1-2):23-33. PMID: 11457489.
    Citations: 7     Fields:    Translation:AnimalsCells
  53. Iwasaki T, Chin WW, Ko L. Identification and characterization of RRM-containing coactivator activator (CoAA) as TRBP-interacting protein, and its splice variant as a coactivator modulator (CoAM). J Biol Chem. 2001 Sep 07; 276(36):33375-83. PMID: 11443112.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  54. Kubin M, Cassiano L, Chalupny J, Chin W, Cosman D, Fanslow W, Müllberg J, Rousseau AM, Ulrich D, Armitage R. ULBP1, 2, 3: novel MHC class I-related molecules that bind to human cytomegalovirus glycoprotein UL16, activate NK cells. Eur J Immunol. 2001 May; 31(5):1428-37. PMID: 11465099.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  55. Koibuchi N, Yamaoka S, Chin WW. Effect of altered thyroid status on neurotrophin gene expression during postnatal development of the mouse cerebellum. Thyroid. 2001 Mar; 11(3):205-10. PMID: 11327610.
    Citations: 14     Fields:    Translation:Animals
  56. Lizcano F, Koibuchi N, Fukuda H, Dangond F, Chin WW. Cell type-specific roles of histone deacetylase in TR ligand-independent transcriptional repression. Mol Cell Endocrinol. 2001 Feb 14; 172(1-2):13-20. PMID: 11165035.
    Citations: 2     Fields:    Translation:AnimalsCells
  57. Eng PH, Cardona GR, Previti MC, Chin WW, Braverman LE. Regulation of the sodium iodide symporter by iodide in FRTL-5 cells. Eur J Endocrinol. 2001 Feb; 144(2):139-44.