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William A. Carlezon, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. T32MH125786 (CARLEZON, WILLIAM A.) Jul 1, 2021 - Jun 30, 2026
    Training to Enhance Alignment of Psychiatry and Neuroscience
    Role: Principal Investigator
  2. P50MH115874 (CARLEZON, WILLIAM A.) Apr 1, 2019 - Feb 28, 2024
    Silvio O. Conte Center for Stress Peptide Advanced Research, Education, & Dissemination (SPARED) at McLean Hospital
    Role: Principal Investigator
  3. R01MH097860 (CARLEZON, WILLIAM A.) May 1, 2013 - Mar 31, 2018
    PACAP signaling in stress and anxiety
    Role: Principal Investigator
  4. R56MH097860 (CARLEZON, WILLIAM A) Jun 20, 2012 - Apr 30, 2013
    PACAP signaling in stress and anxiety
    Role: Principal Investigator
  5. R03DA030586 (CARLEZON, WILLIAM A) Sep 30, 2010 - May 31, 2013
    Kappa opioid antagonists: synthesis, potency, selectivity, and time-course
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Linton SR, Murphy M, Schroder HS, Breiger M, Iturra-Mena AM, Kangas BD, Bergman J, Carlezon WA, Risbrough VB, Barnes SA, Der-Avakian A, Pizzagalli DA. Effects of modafinil on electroencephalographic microstates in healthy adults. Psychopharmacology (Berl). 2022 Aug; 239(8):2573-2584. PMID: 35471613; PMCID: PMC9296596.
    Citations:    Fields:    Translation:Humans
  2. Missig G, Mehta N, Robbins JO, Good CH, Iliopoulos-Tsoutsouvas C, Makriyannis A, Nikas SP, Bergman J, Carlezon WA, Paronis CA. Altered sleep during spontaneous cannabinoid withdrawal in male mice. Behav Pharmacol. 2022 04 01; 33(2&3):195-205. PMID: 35288510; PMCID: PMC8928162.
    Citations: 2     Fields:    Translation:Animals
  3. Schroder HS, Iturra-Mena AM, Breiger M, Linton SR, Robble MA, Kangas BD, Bergman J, Nickels S, Vitaliano G, Der-Avakian A, Barnes SA, Carlezon WA, Pizzagalli DA. Error-related Alpha Suppression: Scalp Topography and (Lack of) Modulation by Modafinil. J Cogn Neurosci. 2022 03 31; 34(5):864-876. PMID: 35195725.
    Citations:    Fields:    Translation:Humans
  4. Ressler KJ, Berretta S, Bolshakov VY, Rosso IM, Meloni EG, Rauch SL, Carlezon WA. Post-traumatic stress disorder: clinical and translational neuroscience from cells to circuits. Nat Rev Neurol. 2022 05; 18(5):273-288. PMID: 35352034.
    Citations: 2     Fields:    Translation:HumansAnimals
  5. Hupalo S, Martinowich K, Carlezon WA, Jordan CJ. Neuropsychopharmacology (NPP) 2020 report on gender balance among corresponding authors and reviewers: before and during the COVID-19 pandemic. Neuropsychopharmacology. 2022 04; 47(5):973-975. PMID: 35190705; PMCID: PMC8860368.
    Citations:    Fields:    Translation:HumansPHPublic Health
  6. Carlezon WA, Missig G. Super glue: emerging roles for non-neuronal brain cells in mental health. Neuropsychopharmacology. 2022 01; 47(1):391-392. PMID: 34312495; PMCID: PMC8617164.
    Citations: 1     Fields:    
  7. Missig G, Fritsch EL, Mehta N, Damon ME, Jarrell EM, Bartlett AA, Carroll FI, Carlezon WA. Blockade of kappa-opioid receptors amplifies microglia-mediated inflammatory responses. Pharmacol Biochem Behav. 2022 01; 212:173301. PMID: 34826432; PMCID: PMC8748402.
    Citations:    Fields:    Translation:AnimalsCells
  8. Benham RS, Choi C, Hodgson NW, Hewage NB, Kastli R, Donahue RJ, Muschamp JW, Engin E, Carlezon WA, Hensch TK, Rudolph U. a2-containing ?-aminobutyric acid type A receptors promote stress resiliency in male mice. Neuropsychopharmacology. 2021 11; 46(12):2197-2206. PMID: 34408277; PMCID: PMC8505491.
    Citations:    Fields:    Translation:Animals
  9. Kangas BD, Iturra-Mena AM, Robble MA, Luc OT, Potter D, Nickels S, Bergman J, Carlezon WA, Pizzagalli DA. Concurrent electrophysiological recording and cognitive testing in a rodent touchscreen environment. Sci Rep. 2021 06 03; 11(1):11665. PMID: 34083596; PMCID: PMC8175731.
    Citations:    Fields:    Translation:Animals
  10. Borrelli KN, Langan CR, Dubinsky KR, Szumlinski KK, Carlezon WA, Chartoff EH, Bryant CD. Intracranial self-stimulation and concomitant behaviors following systemic methamphetamine administration in Hnrnph1 mutant mice. Psychopharmacology (Berl). 2021 Jul; 238(7):2031-2041. PMID: 33758972.
    Citations:    Fields:    Translation:Animals
  11. Robble MA, Schroder HS, Kangas BD, Nickels S, Breiger M, Iturra-Mena AM, Perlo S, Cardenas E, Der-Avakian A, Barnes SA, Leutgeb S, Risbrough VB, Vitaliano G, Bergman J, Carlezon WA, Pizzagalli DA. Concordant neurophysiological signatures of cognitive control in humans and rats. Neuropsychopharmacology. 2021 06; 46(7):1252-1262. PMID: 33746206; PMCID: PMC8134486.
    Citations: 3     Fields:    Translation:HumansAnimals
  12. Jordan CJ, Martinowich K, Carlezon WA. Neuropsychopharmacology (NPP): update on relationships between online attention and citation counts. Neuropsychopharmacology. 2021 05; 46(6):1061-1063. PMID: 33603138; PMCID: PMC8115066.
    Citations:    Fields:    
  13. McCullough KM, Missig G, Robble MA, Foilb AR, Wells AM, Hartmann J, Anderson KJ, Neve RL, Nestler EJ, Ressler KJ, Carlezon WA. Nucleus Accumbens Medium Spiny Neuron Subtypes Differentially Regulate Stress-Associated Alterations in Sleep Architecture. Biol Psychiatry. 2021 06 15; 89(12):1138-1149. PMID: 33715826; PMCID: PMC8178228.
    Citations: 5     Fields:    Translation:AnimalsCells
  14. McCullough KM, Chatzinakos C, Hartmann J, Missig G, Neve RL, Fenster RJ, Carlezon WA, Daskalakis NP, Ressler KJ. Author Correction: Genome-wide translational profiling of amygdala Crh-expressing neurons reveals role for CREB in fear extinction learning. Nat Commun. 2020 Oct 27; 11(1):5529. PMID: 33110083.
    Citations:    Fields:    
  15. McCullough KM, Chatzinakos C, Hartmann J, Missig G, Neve RL, Fenster RJ, Carlezon WA, Daskalakis NP, Ressler KJ. Genome-wide translational profiling of amygdala Crh-expressing neurons reveals role for CREB in fear extinction learning. Nat Commun. 2020 10 14; 11(1):5180. PMID: 33057013.
    Citations: 5     Fields:    Translation:AnimalsCells
  16. Jordan CJ, Carlezon WA. Effects of the COVID-19 pandemic on gender representation among corresponding authors of Neuropsychopharmacology (NPP) manuscripts: submissions during January-June, 2020. Neuropsychopharmacology. 2021 01; 46(2):269-270. PMID: 32967001.
    Citations: 2     Fields:    Translation:HumansPHPublic Health
  17. Robble MA, Holloway IL, Ridener E, Webber CJ, Caine SB, Meloni EG, Desai RI, Carlezon WA. Differential Effects of Nicotine and Nicotine Withdrawal on Fear Conditioning in Male Rats. Int J Neuropsychopharmacol. 2020 07 29; 23(7):469-479. PMID: 32242615.
    Citations:    Fields:    Translation:Animals
  18. Carlezon WA. NPP statement on racism, discrimination, and abuse of power. Neuropsychopharmacology. 2020 09; 45(10):1589-1590. PMID: 32563182.
    Citations:    Fields:    
  19. Selley DE, Lazenka MF, Sim-Selley LJ, Secor McVoy JR, Potter DN, Chartoff EH, Carlezon WA, Negus SS. Attenuated dopamine receptor signaling in nucleus accumbens core in a rat model of chemically-induced neuropathy. Neuropharmacology. 2020 04; 166:107935. PMID: 31917153; PMCID: PMC7654441.
    Citations: 6     Fields:    Translation:AnimalsCells
  20. Carlezon WA, Kim W, Missig G, Finger BC, Landino SM, Alexander AJ, Mokler EL, Robbins JO, Li Y, Bolshakov VY, McDougle CJ, Kim KS. Maternal and early postnatal immune activation produce sex-specific effects on autism-like behaviors and neuroimmune function in mice. Sci Rep. 2019 11 15; 9(1):16928. PMID: 31729416.
    Citations: 31     Fields:    Translation:AnimalsPHPublic Health
  21. Page S, Mavrikaki MM, Lintz T, Puttick D, Roberts E, Rosen H, Carroll FI, Carlezon WA, Chartoff EH. Behavioral Pharmacology of Novel Kappa Opioid Receptor Antagonists in Rats. Int J Neuropsychopharmacol. 2019 11 01; 22(11):735-745. PMID: 31613314; PMCID: PMC7145521.
    Citations: 15     Fields:    Translation:Animals
  22. Jordan CJ, Carlezon WA. NPP (Neuropsychopharmacology): update on gender balance in journal function. Neuropsychopharmacology. 2019 12; 44(13):2145-2148. PMID: 31480071; PMCID: PMC6898399.
    Citations: 1     Fields:    Translation:Humans
  23. Jordan CJ, Neigh GN, Carlezon WA. Neuropsychopharmacology (NPP): relationships between online attention and citation counts. Neuropsychopharmacology. 2019 08; 44(9):1513-1515. PMID: 31146279.
    Citations:    Fields:    Translation:Humans
  24. Missig G, McDougle CJ, Carlezon WA. Sleep as a translationally-relevant endpoint in studies of autism spectrum disorder (ASD). Neuropsychopharmacology. 2020 01; 45(1):90-103. PMID: 31060044; PMCID: PMC6879602.
    Citations: 7     Fields:    Translation:HumansAnimals
  25. Bale TL, Abel T, Akil H, Carlezon WA, Moghaddam B, Nestler EJ, Ressler KJ, Thompson SM. The critical importance of basic animal research for neuropsychiatric disorders. Neuropsychopharmacology. 2019 07; 44(8):1349-1353. PMID: 31048727.
    Citations: 43     Fields:    Translation:HumansAnimals
  26. Missig G, Robbins JO, Mokler EL, McCullough KM, Bilbo SD, McDougle CJ, Carlezon WA. Sex-dependent neurobiological features of prenatal immune activation via TLR7. Mol Psychiatry. 2020 10; 25(10):2330-2341. PMID: 30610201; PMCID: PMC7515834.
    Citations: 15     Fields:    Translation:Animals
  27. Meloni EG, Kaye KT, Venkataraman A, Carlezon WA. PACAP increases Arc/Arg 3.1 expression within the extended amygdala after fear conditioning in rats. Neurobiol Learn Mem. 2019 01; 157:24-34. PMID: 30458282; PMCID: PMC6494622.
    Citations: 11     Fields:    Translation:AnimalsCells
  28. Jordan CJ, Carlezon WA. Neuropsychopharmacology (NPP): gender balance in journal function. Neuropsychopharmacology. 2019 01; 44(1):4-8. PMID: 30188510.
    Citations: 2     Fields:    Translation:Humans
  29. Baker JT, Germine LT, Ressler KJ, Rauch SL, Carlezon WA. Digital devices and continuous telemetry: opportunities for aligning psychiatry and neuroscience. Neuropsychopharmacology. 2018 12; 43(13):2499-2503. PMID: 30120409.
    Citations: 14     Fields:    Translation:HumansAnimals
  30. Li Y, Missig G, Finger BC, Landino SM, Alexander AJ, Mokler EL, Robbins JO, Manasian Y, Kim W, Kim KS, McDougle CJ, Carlezon WA, Bolshakov VY. Maternal and Early Postnatal Immune Activation Produce Dissociable Effects on Neurotransmission in mPFC-Amygdala Circuits. J Neurosci. 2018 03 28; 38(13):3358-3372. PMID: 29491010; PMCID: PMC6596064.
    Citations: 28     Fields:    Translation:AnimalsCells
  31. McCullough KM, Morrison FG, Hartmann J, Carlezon WA, Ressler KJ. Quantified Coexpression Analysis of Central Amygdala Subpopulations. eNeuro. 2018 Jan-Feb; 5(1). PMID: 29445764.
    Citations: 46     Fields:    Translation:AnimalsCells
  32. Puhl MD, Desai RI, Takagi S, Presti KT, Doyle MR, Donahue RJ, Landino SM, Bergman J, Carlezon WA, Coyle JT. N-Methyl-d-aspartate receptor co-agonist availability affects behavioral and neurochemical responses to cocaine: insights into comorbid schizophrenia and substance abuse. Addict Biol. 2019 01; 24(1):40-50. PMID: 29168271.
    Citations: 7     Fields:    Translation:Animals
  33. Missig G, Mokler EL, Robbins JO, Alexander AJ, McDougle CJ, Carlezon WA. Perinatal Immune Activation Produces Persistent Sleep Alterations and Epileptiform Activity in Male Mice. Neuropsychopharmacology. 2018 02; 43(3):482-491. PMID: 28984294.
    Citations: 14     Fields:    Translation:Animals
  34. Wells AM, Ridener E, Bourbonais CA, Kim W, Pantazopoulos H, Carroll FI, Kim KS, Cohen BM, Carlezon WA. Effects of Chronic Social Defeat Stress on Sleep and Circadian Rhythms Are Mitigated by Kappa-Opioid Receptor Antagonism. J Neurosci. 2017 08 09; 37(32):7656-7668. PMID: 28674176; PMCID: PMC5551063.
    Citations: 39     Fields:    Translation:Animals
  35. Carlezon WA, Abi-Dargham A. NPP: Our Designs for the Future. Neuropsychopharmacology. 2017 Jun; 42(7):1371-1372. PMID: 28496174.
    Citations:    Fields:    Translation:Humans
  36. Lezak KR, Missig G, Carlezon WA. Behavioral methods to study anxiety in rodents. Dialogues Clin Neurosci. 2017 06; 19(2):181-191. PMID: 28867942; PMCID: PMC5573562.
    Citations: 62     Fields:    Translation:Animals
  37. Der-Avakian A, D'Souza MS, Potter DN, Chartoff EH, Carlezon WA, Pizzagalli DA, Markou A. Social defeat disrupts reward learning and potentiates striatal nociceptin/orphanin FQ mRNA in rats. Psychopharmacology (Berl). 2017 05; 234(9-10):1603-1614. PMID: 28280884; PMCID: PMC5420477.
    Citations: 23     Fields:    Translation:HumansAnimals
  38. Tejeda HA, Wu J, Kornspun AR, Pignatelli M, Kashtelyan V, Krashes MJ, Lowell BB, Carlezon WA, Bonci A. Pathway- and Cell-Specific Kappa-Opioid Receptor Modulation of Excitation-Inhibition Balance Differentially Gates D1 and D2 Accumbens Neuron Activity. Neuron. 2017 Jan 04; 93(1):147-163. PMID: 28056342; PMCID: PMC5808882.
    Citations: 63     Fields:    Translation:AnimalsCells
  39. Pizzagalli DA, Carlezon WA. Error Processing in Depressive States: A Translational Opportunity? Neuropsychopharmacology. 2017 01; 42(1):372. PMID: 27909318; PMCID: PMC5143496.
    Citations: 1     Fields:    Translation:HumansAnimals
  40. Carlezon WA, Krystal AD. Kappa-Opioid Antagonists for Psychiatric Disorders: From Bench to Clinical Trials. Depress Anxiety. 2016 10; 33(10):895-906. PMID: 27699938; PMCID: PMC5288841.
    Citations: 55     Fields:    Translation:HumansAnimals
  41. Nygard SK, Hourguettes NJ, Sobczak GG, Carlezon WA, Bruchas MR. Stress-Induced Reinstatement of Nicotine Preference Requires Dynorphin/Kappa Opioid Activity in the Basolateral Amygdala. J Neurosci. 2016 09 21; 36(38):9937-48. PMID: 27656031; PMCID: PMC5030354.
    Citations: 25     Fields:    Translation:Animals
  42. Van't Veer A, Smith KL, Cohen BM, Carlezon WA, Bechtholt AJ. Kappa-opioid receptors differentially regulate low and high levels of ethanol intake in female mice. Brain Behav. 2016 09; 6(9):e00523. PMID: 27688945.
    Citations: 7     Fields:    
  43. Krystal JH, Abi-Dargham A, Akbarian S, Arnsten AFT, Barch DM, Bearden CE, Braff DL, Brown ES, Bullmore ET, Carlezon WA, Carter CS, Cook EH, Daskalakis ZJ, DiLeone RJ, Duman RS, Grace AA, Hariri AR, Harrison PJ, Hiroi N, Kenny PJ, Kleinman JE, Krystal AD, Lewis DA, Lipska BK, Marder SR, Mason GF, Mathalon DH, McClung CA, McDougle CJ, McIntosh AM, McMahon FJ, Mirnics K, Monteggia LM, Narendran R, Nestler EJ, Neumeister A, O'Donovan MC, Öngür D, Pariante CM, Paulus MP, Pearlson G, Phillips ML, Pine DS, Pizzagalli DA, Pletnikov MV, Ragland JD, Rapoport JL, Ressler KJ, Russo SJ, Sanacora G, Sawa A, Schatzberg AF, Shaham Y, Shamay-Tsoory SG, Sklar P, State MW, Stein MB, Strakowski SM, Taylor SF, Turecki G, Turetsky BI, Weissman MM, Zachariou V, Zarate CA, Zubieta JK. Constance E. Lieber, Theodore R. Stanley, and the Enduring Impact of Philanthropy on Psychiatry Research. Biol Psychiatry. 2016 07 15; 80(2):84-86. PMID: 27346079; PMCID: PMC6150945.
    Citations: 1     Fields:    
  44. Russell SE, Puttick DJ, Sawyer AM, Potter DN, Mague S, Carlezon WA, Chartoff EH. Nucleus Accumbens AMPA Receptors Are Necessary for Morphine-Withdrawal-Induced Negative-Affective States in Rats. J Neurosci. 2016 05 25; 36(21):5748-62. PMID: 27225765; PMCID: PMC4879196.
    Citations: 22     Fields:    Translation:Animals
  45. Heilig M, Carlezon WA. Circumspectives: Cannabis and Psychiatric Illness: Blunt Thoughts. Neuropsychopharmacology. 2016 Jan; 41(2):391-2. PMID: 26555278.
    Citations:    Fields:    Translation:HumansAnimals
  46. Meloni EG, Venkataraman A, Donahue RJ, Carlezon WA. Bi-directional effects of pituitary adenylate cyclase-activating polypeptide (PACAP) on fear-related behavior and c-Fos expression after fear conditioning in rats. Psychoneuroendocrinology. 2016 Feb; 64:12-21. PMID: 26590791.
    Citations: 15     Fields:    Translation:Animals
  47. Penrod RD, Wells AM, Carlezon WA, Cowan CW. Use of Adeno-Associated and Herpes Simplex Viral Vectors for In Vivo Neuronal Expression in Mice. Curr Protoc Neurosci. 2015 Oct 01; 73:4.37.1-4.37.31. PMID: 26426386.
    Citations: 12     Fields:    Translation:AnimalsCells
  48. Donahue RJ, Landino SM, Golden SA, Carroll FI, Russo SJ, Carlezon WA. Effects of acute and chronic social defeat stress are differentially mediated by the dynorphin/kappa-opioid receptor system. Behav Pharmacol. 2015 Oct; 26(7 Spec No):654-63. PMID: 26110224.
    Citations: 28     Fields:    Translation:AnimalsCells
  49. Heilig M, Carlezon WA. Circumspectives: The Replacements. Neuropsychopharmacology. 2015 Jul; 40(8):1813-4. PMID: 26068571.
    Citations: 1     Fields:    Translation:Humans
  50. Donahue RJ, Venkataraman A, Carroll FI, Meloni EG, Carlezon WA. Pituitary Adenylate Cyclase-Activating Polypeptide Disrupts Motivation, Social Interaction, and Attention in Male Sprague Dawley Rats. Biol Psychiatry. 2016 12 15; 80(12):955-964. PMID: 26229039; PMCID: PMC4684793.
    Citations: 10     Fields:    Translation:Animals
  51. Beard C, Donahue RJ, Dillon DG, Van't Veer A, Webber C, Lee J, Barrick E, Hsu KJ, Foti D, Carroll FI, Carlezon WA, Björgvinsson T, Pizzagalli DA. Abnormal error processing in depressive states: a translational examination in humans and rats. Transl Psychiatry. 2015 May 12; 5:e564. PMID: 25966364.
    Citations: 10     Fields:    Translation:HumansAnimals
  52. Dow AL, Lin TV, Chartoff EH, Potter D, McPhie DL, Van't Veer AV, Knoll AT, Lee KN, Neve RL, Patel TB, Ongur D, Cohen BM, Carlezon WA. Sprouty2 in the dorsal hippocampus regulates neurogenesis and stress responsiveness in rats. PLoS One. 2015; 10(3):e0120693. PMID: 25822989.
    Citations:    Fields:    Translation:AnimalsCells
  53. John CS, Sypek EI, Carlezon WA, Cohen BM, Öngür D, Bechtholt AJ. Blockade of the GLT-1 Transporter in the Central Nucleus of the Amygdala Induces both Anxiety and Depressive-Like Symptoms. Neuropsychopharmacology. 2015 Jun; 40(7):1700-8. PMID: 25586634.
    Citations: 29     Fields:    Translation:Animals
  54. Carlezon WA, George TP. Circumspectives: the promise of ketamine. Neuropsychopharmacology. 2015 Jan; 40(2):257-8. PMID: 25502471.
    Citations: 1     Fields:    Translation:HumansAnimals
  55. Vahabzadeh A, Landino SM, Finger BC, Carlezon WA, McDougle CJ. Neural targets in the study and treatment of social cognition in autism spectrum disorder. Handb Exp Pharmacol. 2015; 228:309-34. PMID: 25977088.
    Citations:    Fields:    Translation:HumansAnimals
  56. McDougle CJ, Landino SM, Vahabzadeh A, O'Rourke J, Zurcher NR, Finger BC, Palumbo ML, Helt J, Mullett JE, Hooker JM, Carlezon WA. Toward an immune-mediated subtype of autism spectrum disorder. Brain Res. 2015 Aug 18; 1617:72-92. PMID: 25445995.
    Citations: 40     Fields:    Translation:HumansAnimals
  57. Yap JJ, Chartoff EH, Holly EN, Potter DN, Carlezon WA, Miczek KA. Social defeat stress-induced sensitization and escalated cocaine self-administration: the role of ERK signaling in the rat ventral tegmental area. Psychopharmacology (Berl). 2015 May; 232(9):1555-69. PMID: 25373870.
    Citations: 18     Fields:    Translation:AnimalsCells
  58. Öngür D, Bechtholt AJ, Carlezon WA, Cohen BM. Glial abnormalities in mood disorders. Harv Rev Psychiatry. 2014 Nov-Dec; 22(6):334-7. PMID: 25377605.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  59. Leitl MD, Potter DN, Cheng K, Rice KC, Carlezon WA, Negus SS. Sustained pain-related depression of behavior: effects of intraplantar formalin and complete freund's adjuvant on intracranial self-stimulation (ICSS) and endogenous kappa opioid biomarkers in rats. Mol Pain. 2014 Sep 23; 10:62. PMID: 25245060.
    Citations: 32     Fields:    Translation:Animals
  60. Chartoff EH, Carlezon WA. Drug withdrawal conceptualized as a stressor. Behav Pharmacol. 2014 Sep; 25(5-6):473-92. PMID: 25083570.
    Citations: 14     Fields:    Translation:HumansAnimals
  61. Muschamp JW, Hollander JA, Thompson JL, Voren G, Hassinger LC, Onvani S, Kamenecka TM, Borgland SL, Kenny PJ, Carlezon WA. Hypocretin (orexin) facilitates reward by attenuating the antireward effects of its cotransmitter dynorphin in ventral tegmental area. Proc Natl Acad Sci U S A. 2014 Apr 22; 111(16):E1648-55. PMID: 24706819.
    Citations: 108     Fields:    Translation:AnimalsCells
  62. Donahue RJ, Muschamp JW, Russo SJ, Nestler EJ, Carlezon WA. Effects of striatal ?FosB overexpression and ketamine on social defeat stress-induced anhedonia in mice. Biol Psychiatry. 2014 Oct 01; 76(7):550-8. PMID: 24495460.
    Citations: 91     Fields:    Translation:Animals
  63. Carlezon WA. Circumspectives: viewing a topic from multiple perspectives. Neuropsychopharmacology. 2014 Jan; 39(2):253. PMID: 24336423.
    Citations:    Fields:    Translation:Humans
  64. Leitl MD, Onvani S, Bowers MS, Cheng K, Rice KC, Carlezon WA, Banks ML, Negus SS. Pain-related depression of the mesolimbic dopamine system in rats: expression, blockade by analgesics, and role of endogenous ?-opioids. Neuropsychopharmacology. 2014 Feb; 39(3):614-24. PMID: 24008352.
    Citations: 48     Fields:    Translation:Animals
  65. Munro TA, Huang XP, Inglese C, Perrone MG, Van't Veer A, Carroll FI, Béguin C, Carlezon WA, Colabufo NA, Cohen BM, Roth BL. Selective ? opioid antagonists nor-BNI, GNTI and JDTic have low affinities for non-opioid receptors and transporters. PLoS One. 2013; 8(8):e70701. PMID: 23976952.
    Citations: 12     Fields:    Translation:HumansCells
  66. Van't Veer A, Carlezon WA. Role of kappa-opioid receptors in stress and anxiety-related behavior. Psychopharmacology (Berl). 2013 Oct; 229(3):435-52. PMID: 23836029.
    Citations: 125     Fields:    Translation:HumansAnimals
  67. Rauch SL, Carlezon WA. Neuroscience. Illuminating the neural circuitry of compulsive behaviors. Science. 2013 Jun 07; 340(6137):1174-5. PMID: 23744931.
    Citations: 4     Fields:    Translation:Animals
  68. Li Y, Meloni EG, Carlezon WA, Milad MR, Pitman RK, Nader K, Bolshakov VY. Learning and reconsolidation implicate different synaptic mechanisms. Proc Natl Acad Sci U S A. 2013 Mar 19; 110(12):4798-803. PMID: 23487762; PMCID: PMC3607055.
    Citations: 23     Fields:    Translation:AnimalsCells
  69. Van't Veer A, Bechtholt AJ, Onvani S, Potter D, Wang Y, Liu-Chen LY, Schütz G, Chartoff EH, Rudolph U, Cohen BM, Carlezon WA. Ablation of kappa-opioid receptors from brain dopamine neurons has anxiolytic-like effects and enhances cocaine-induced plasticity. Neuropsychopharmacology. 2013 Jul; 38(8):1585-97. PMID: 23446450.
    Citations: 34     Fields:    Translation:AnimalsCells
  70. Carroll FI, Carlezon WA. Development of ? opioid receptor antagonists. J Med Chem. 2013 Mar 28; 56(6):2178-95. PMID: 23360448.
    Citations: 80     Fields:    Translation:HumansAnimalsCells
  71. Coleman BR, Carlezon WA, Myers KM. Extinction of conditioned opiate withdrawal in rats is blocked by intracerebroventricular infusion of an NMDA receptor antagonist. Neurosci Lett. 2013 Apr 29; 541:39-42. PMID: 23416323.
    Citations: 3     Fields:    Translation:Animals
  72. Muschamp JW, Carlezon WA. Roles of nucleus accumbens CREB and dynorphin in dysregulation of motivation. Cold Spring Harb Perspect Med. 2013 Feb 01; 3(2):a012005. PMID: 23293139.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  73. Carlezon WA. Neuropsychopharmacology: the 2013 transition in leadership. Neuropsychopharmacology. 2013 Jan; 38(2):257-8. PMID: 23247279.
    Citations:    Fields:    Translation:Humans
  74. McDougle CJ, Carlezon WA. Neuroinflammation and autism: toward mechanisms and treatments. Neuropsychopharmacology. 2013 Jan; 38(1):241-2. PMID: 23147483.
    Citations: 3     Fields:    Translation:HumansAnimals
  75. Cho JH, Zushida K, Shumyatsky GP, Carlezon WA, Meloni EG, Bolshakov VY. Pituitary adenylate cyclase-activating polypeptide induces postsynaptically expressed potentiation in the intra-amygdala circuit. J Neurosci. 2012 Oct 10; 32(41):14165-77. PMID: 23055486.
    Citations: 28     Fields:    Translation:Animals
  76. Murphy BL, Stoll AL, Harris PQ, Ravichandran C, Babb SM, Carlezon WA, Cohen BM. Omega-3 fatty acid treatment, with or without cytidine, fails to show therapeutic properties in bipolar disorder: a double-blind, randomized add-on clinical trial. J Clin Psychopharmacol. 2012 Oct; 32(5):699-703. PMID: 22926607.
    Citations: 15     Fields:    Translation:Humans
  77. Van't Veer A, Yano JM, Carroll FI, Cohen BM, Carlezon WA. Corticotropin-releasing factor (CRF)-induced disruption of attention in rats is blocked by the ?-opioid receptor antagonist JDTic. Neuropsychopharmacology. 2012 Dec; 37(13):2809-16. PMID: 22948977.
    Citations: 34     Fields:    Translation:Animals
  78. Béguin C, Potter DN, Carlezon WA, Stöhr T, Cohen BM. Effects of the anticonvulsant lacosamide compared to valproate and lamotrigine on cocaine-enhanced reward in rats. Brain Res. 2012 Oct 15; 1479:44-51. PMID: 22940183.
    Citations: 5     Fields:    Translation:Animals
  79. Reynolds LM, Engin E, Tantillo G, Lau HM, Muschamp JW, Carlezon WA, Rudolph U. Differential roles of GABA(A) receptor subtypes in benzodiazepine-induced enhancement of brain-stimulation reward. Neuropsychopharmacology. 2012 Oct; 37(11):2531-40. PMID: 22763624.
    Citations: 28     Fields:    Translation:Animals
  80. Myers KM, Carlezon WA. Reply to: Maintaining Clinical Relevance: Considerations for the Future of Research into D-Cycloserine and Cue Exposure Therapy for Addiction. Biol Psychiatry. 2012 Dec 1; 72(11):e31-2. PMID: 22748615.
  81. John CS, Smith KL, Van't Veer A, Gompf HS, Carlezon WA, Cohen BM, Öngür D, Bechtholt-Gompf AJ. Blockade of astrocytic glutamate uptake in the prefrontal cortex induces anhedonia. Neuropsychopharmacology. 2012 Oct; 37(11):2467-75. PMID: 22739467.
    Citations: 53     Fields:    Translation:AnimalsCells
  82. Myers KM, Carlezon WA. D-cycloserine effects on extinction of conditioned responses to drug-related cues. Biol Psychiatry. 2012 Jun 01; 71(11):947-55. PMID: 22579305.
    Citations: 40     Fields:    Translation:HumansAnimals
  83. Munro TA, Berry LM, Van't Veer A, Béguin C, Carroll FI, Zhao Z, Carlezon WA, Cohen BM. Long-acting ? opioid antagonists nor-BNI, GNTI and JDTic: pharmacokinetics in mice and lipophilicity. BMC Pharmacol. 2012 May 29; 12:5. PMID: 22642416.
    Citations: 40     Fields:    Translation:AnimalsCells
  84. Myers KM, Bechtholt-Gompf AJ, Coleman BR, Carlezon WA. Extinction of conditioned opiate withdrawal in rats in a two-chambered place conditioning apparatus. Nat Protoc. 2012 Feb 23; 7(3):517-26. PMID: 22362157.
    Citations: 4     Fields:    Translation:Animals
  85. Cho JH, Bayazitov IT, Meloni EG, Myers KM, Carlezon WA, Zakharenko SS, Bolshakov VY. Coactivation of thalamic and cortical pathways induces input timing-dependent plasticity in amygdala. Nat Neurosci. 2011 Dec 11; 15(1):113-22. PMID: 22158512.
    Citations: 33     Fields:    Translation:AnimalsCells
  86. Béguin C, Potuzak J, Xu W, Liu-Chen LY, Streicher JM, Groer CE, Bohn LM, Carlezon WA, Cohen BM. Differential signaling properties at the kappa opioid receptor of 12-epi-salvinorin A and its analogues. Bioorg Med Chem Lett. 2012 Jan 15; 22(2):1023-6. PMID: 22204910.
    Citations: 16     Fields:    Translation:HumansCells
  87. Wong DL, Tai TC, Wong-Faull DC, Claycomb R, Meloni EG, Myers KM, Carlezon WA, Kvetnansky R. Epinephrine: a short- and long-term regulator of stress and development of illness : a potential new role for epinephrine in stress. Cell Mol Neurobiol. 2012 Jul; 32(5):737-48. PMID: 22090159.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  88. Muschamp JW, Nemeth CL, Robison AJ, Nestler EJ, Carlezon WA. ?FosB enhances the rewarding effects of cocaine while reducing the pro-depressive effects of the kappa-opioid receptor agonist U50488. Biol Psychiatry. 2012 Jan 01; 71(1):44-50. PMID: 21962331.
    Citations: 22     Fields:    Translation:Animals
  89. Muschamp JW, Van't Veer A, Carlezon WA. Tracking down the molecular substrates of stress: new roles for p38a MAPK and kappa-opioid receptors. Neuron. 2011 Aug 11; 71(3):383-5. PMID: 21835335.
    Citations: 7     Fields:    
  90. Melief EJ, Miyatake M, Carroll FI, Béguin C, Carlezon WA, Cohen BM, Grimwood S, Mitch CH, Rorick-Kehn L, Chavkin C. Duration of action of a broad range of selective ?-opioid receptor antagonists is positively correlated with c-Jun N-terminal kinase-1 activation. Mol Pharmacol. 2011 Nov; 80(5):920-9. PMID: 21832171.
    Citations: 64     Fields:    Translation:HumansAnimalsCells
  91. Potter DN, Damez-Werno D, Carlezon WA, Cohen BM, Chartoff EH. Repeated exposure to the ?-opioid receptor agonist salvinorin A modulates extracellular signal-regulated kinase and reward sensitivity. Biol Psychiatry. 2011 Oct 15; 70(8):744-753. PMID: 21757186.
    Citations: 43     Fields:    Translation:AnimalsCells
  92. Chartoff E, Sawyer A, Rachlin A, Potter D, Pliakas A, Carlezon WA. Blockade of kappa opioid receptors attenuates the development of depressive-like behaviors induced by cocaine withdrawal in rats. Neuropharmacology. 2012 Jan; 62(1):167-76. PMID: 21736885.
    Citations: 78     Fields:    Translation:Animals
  93. Knoll AT, Muschamp JW, Sillivan SE, Ferguson D, Dietz DM, Meloni EG, Carroll FI, Nestler EJ, Konradi C, Carlezon WA. Kappa opioid receptor signaling in the basolateral amygdala regulates conditioned fear and anxiety in rats. Biol Psychiatry. 2011 Sep 01; 70(5):425-33. PMID: 21531393.
    Citations: 83     Fields:    Translation:AnimalsCells
  94. Paine TA, Slipp LE, Carlezon WA. Schizophrenia-like attentional deficits following blockade of prefrontal cortex GABAA receptors. Neuropsychopharmacology. 2011 Jul; 36(8):1703-13. PMID: 21490590.
    Citations: 45     Fields:    Translation:Animals
  95. Muschamp JW, Van't Veer A, Parsegian A, Gallo MS, Chen M, Neve RL, Meloni EG, Carlezon WA. Activation of CREB in the nucleus accumbens shell produces anhedonia and resistance to extinction of fear in rats. J Neurosci. 2011 Feb 23; 31(8):3095-103. PMID: 21414930.
    Citations: 54     Fields:    Translation:Animals
  96. Bechtholt-Gompf AJ, Smith KL, John CS, Kang HH, Carlezon WA, Cohen BM, Ongür D. CD-1 and Balb/cJ mice do not show enduring antidepressant-like effects of ketamine in tests of acute antidepressant efficacy. Psychopharmacology (Berl). 2011 Jun; 215(4):689-95. PMID: 21274700.
    Citations: 21     Fields:    Translation:Animals
  97. Smith KS, Meloni EG, Myers KM, Van't Veer A, Carlezon WA, Rudolph U. Reduction of fear-potentiated startle by benzodiazepines in C57BL/6J mice. Psychopharmacology (Berl). 2011 Feb; 213(4):697-706. PMID: 20922362.
    Citations: 9     Fields:    Translation:Animals
  98. Myers KM, Carlezon WA, Davis M. Glutamate receptors in extinction and extinction-based therapies for psychiatric illness. Neuropsychopharmacology. 2011 Jan; 36(1):274-93. PMID: 20631689.
    Citations: 88     Fields:    Translation:HumansAnimals
  99. Bechtholt-Gompf AJ, Walther HV, Adams MA, Carlezon WA, Ongür D, Cohen BM. Blockade of astrocytic glutamate uptake in rats induces signs of anhedonia and impaired spatial memory. Neuropsychopharmacology. 2010 Sep; 35(10):2049-59. PMID: 20531459.
    Citations: 64     Fields:    Translation:AnimalsCells
  100. Carlezon WA, Miczek KA. Ascent of the kappa-opioid receptor in psychopharmacology. Psychopharmacology (Berl). 2010 Jun; 210(2):107-8. PMID: 20401604.
    Citations: 5     Fields:    Translation:HumansAnimals
  101. Nemeth CL, Paine TA, Rittiner JE, Béguin C, Carroll FI, Roth BL, Cohen BM, Carlezon WA. Role of kappa-opioid receptors in the effects of salvinorin A and ketamine on attention in rats. Psychopharmacology (Berl). 2010 Jun; 210(2):263-74. PMID: 20358363.
    Citations: 41     Fields:    Translation:Animals
  102. Myers KM, Carlezon WA. Extinction of drug- and withdrawal-paired cues in animal models: relevance to the treatment of addiction. Neurosci Biobehav Rev. 2010 Nov; 35(2):285-302. PMID: 20109490.
    Citations: 46     Fields:    Translation:HumansAnimals
  103. Loweth JA, Singer BF, Baker LK, Wilke G, Inamine H, Bubula N, Alexander JK, Carlezon WA, Neve RL, Vezina P. Transient overexpression of alpha-Ca2+/calmodulin-dependent protein kinase II in the nucleus accumbens shell enhances behavioral responding to amphetamine. J Neurosci. 2010 Jan 20; 30(3):939-49. PMID: 20089902.
    Citations: 35     Fields:    Translation:Animals
  104. Myers KM, Carlezon WA. D-cycloserine facilitates extinction of naloxone-induced conditioned place aversion in morphine-dependent rats. Biol Psychiatry. 2010 Jan 01; 67(1):85-7. PMID: 19782965.
    Citations: 33     Fields:    Translation:Animals
  105. Ardayfio PA, Leung A, Park J, Hwang DY, Moran-Gates T, Choi YK, Carlezon WA, Tarazi FI, Kim KS. Pitx3-deficient aphakia mice display unique behavioral responses to psychostimulant and antipsychotic drugs. Neuroscience. 2010 Mar 17; 166(2):391-6. PMID: 20026251.
    Citations: 5     Fields:    Translation:AnimalsCells
  106. Knoll AT, Carlezon WA. Dynorphin, stress, and depression. Brain Res. 2010 Feb 16; 1314:56-73. PMID: 19782055.
    Citations: 217     Fields:    Translation:HumansAnimals
  107. Straub CJ, Carlezon WA, Rudolph U. Diazepam and cocaine potentiate brain stimulation reward in C57BL/6J mice. Behav Brain Res. 2010 Jan 05; 206(1):17-20. PMID: 19716385.
    Citations: 20     Fields:    Translation:Animals
  108. Cunningham MG, Connor CM, Carlezon WA, Meloni E. Amygdalar GABAergic-rich neural grafts attenuate anxiety-like behavior in rats. Behav Brain Res. 2009 Dec 14; 205(1):146-53. PMID: 19539663.
    Citations: 8     Fields:    Translation:AnimalsCells
  109. Carlezon WA, Béguin C, Knoll AT, Cohen BM. Kappa-opioid ligands in the study and treatment of mood disorders. Pharmacol Ther. 2009 Sep; 123(3):334-43. PMID: 19497337.
    Citations: 58     Fields:    Translation:HumansAnimals
  110. Riccio A, Li Y, Moon J, Kim KS, Smith KS, Rudolph U, Gapon S, Yao GL, Tsvetkov E, Rodig SJ, Van't Veer A, Meloni EG, Carlezon WA, Bolshakov VY, Clapham DE. Essential role for TRPC5 in amygdala function and fear-related behavior. Cell. 2009 May 15; 137(4):761-72. PMID: 19450521; PMCID: PMC2719954.
    Citations: 130     Fields:    Translation:AnimalsCells
  111. Pereira Do Carmo G, Stevenson GW, Carlezon WA, Negus SS. Effects of pain- and analgesia-related manipulations on intracranial self-stimulation in rats: further studies on pain-depressed behavior. Pain. 2009 Jul; 144(1-2):170-7. PMID: 19435650.
    Citations: 55     Fields:    Translation:Animals
  112. Paine TA, Neve RL, Carlezon WA. Attention deficits and hyperactivity following inhibition of cAMP-dependent protein kinase within the medial prefrontal cortex of rats. Neuropsychopharmacology. 2009 Aug; 34(9):2143-55. PMID: 19387423.
    Citations: 20     Fields:    Translation:Animals
  113. Paine TA, Carlezon WA. Effects of antipsychotic drugs on MK-801-induced attentional and motivational deficits in rats. Neuropharmacology. 2009 Mar; 56(4):788-97. PMID: 19705572.
    Citations: 25     Fields:    Translation:Animals
  114. Carlezon WA, Chartoff E. Perspective: Progress on the study and treatment of depressive illness. Neuropsychopharmacology. 2009 May; 34(6):1361-2. PMID: 19242407.
    Citations: 1     Fields:    Translation:HumansAnimals
  115. Dinieri JA, Nemeth CL, Parsegian A, Carle T, Gurevich VV, Gurevich E, Neve RL, Nestler EJ, Carlezon WA. Altered sensitivity to rewarding and aversive drugs in mice with inducible disruption of cAMP response element-binding protein function within the nucleus accumbens. J Neurosci. 2009 Feb 11; 29(6):1855-9. PMID: 19211892.
    Citations: 58     Fields:    Translation:Animals
  116. Paine TA, Pohlman JM, Carlezon WA. Attention in the 5-choice serial