Harvard Catalyst Profiles

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Alan F. Cowman, Ph.D.

Title
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Department
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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AI044008 (COWMAN, ALAN FREDERICK) Jan 1, 1999 - Feb 28, 2011
    NIH/NIAID
    Adherence of malaria-infected red cells
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. LaMonte GM, Rocamora F, Marapana DS, Gnädig NF, Ottilie S, Luth MR, Worgall TS, Goldgof GM, Mohunlal R, Santha Kumar TR, Thompson JK, Vigil E, Yang J, Hutson D, Johnson T, Huang J, Williams RM, Zou BY, Cheung AL, Kumar P, Egan TJ, Lee MCS, Siegel D, Cowman AF, Fidock DA, Winzeler EA. Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway. Nat Commun. 2020 04 14; 11(1):1780. PMID: 32286267.
    Citations:    
  2. Favuzza P, de Lera Ruiz M, Thompson JK, Triglia T, Ngo A, Steel RWJ, Vavrek M, Christensen J, Healer J, Boyce C, Guo Z, Hu M, Khan T, Murgolo N, Zhao L, Penington JS, Reaksudsan K, Jarman K, Dietrich MH, Richardson L, Guo KY, Lopaticki S, Tham WH, Rottmann M, Papenfuss T, Robbins JA, Boddey JA, Sleebs BE, Sabroux HJ, McCauley JA, Olsen DB, Cowman AF. Dual Plasmepsin-Targeting Antimalarial Agents Disrupt Multiple Stages of the Malaria Parasite Life Cycle. Cell Host Microbe. 2020 04 08; 27(4):642-658.e12. PMID: 32109369.
    Citations:    
  3. Marapana D, Cowman AF. Uncovering the ART of antimalarial resistance. Science. 2020 01 03; 367(6473):22-23. PMID: 31896702.
    Citations:    
  4. Jennison C, Lucantoni L, O'Neill MT, McConville R, Erickson SM, Cowman AF, Sleebs BE, Avery VM, Boddey JA. Inhibition of Plasmepsin V Activity Blocks Plasmodium falciparum Gametocytogenesis and Transmission to Mosquitoes. Cell Rep. 2019 12 17; 29(12):3796-3806.e4. PMID: 31851913.
    Citations:    
  5. Dumont L, Richardson MB, van der Peet P, Marapana DS, Triglia T, Dixon MWA, Cowman AF, Williams SJ, Tilley L, McConville MJ, Cobbold SA. The Metabolite Repair Enzyme Phosphoglycolate Phosphatase Regulates Central Carbon Metabolism and Fosmidomycin Sensitivity in Plasmodium falciparum. mBio. 2019 12 10; 10(6). PMID: 31822583.
    Citations:    
  6. Wilde ML, Triglia T, Marapana D, Thompson JK, Kouzmitchev AA, Bullen HE, Gilson PR, Cowman AF, Tonkin CJ. Protein Kinase A Is Essential for Invasion of Plasmodium falciparum into Human Erythrocytes. mBio. 2019 10 08; 10(5). PMID: 31594816.
    Citations:    
  7. Gilson PR, Kumarasingha R, Thompson J, Zhang X, Penington JS, Kalhor R, Bullen HE, Lehane AM, Dans MG, de Koning-Ward TF, Holien JK, Soares da Costa TP, Hulett MD, Buskes MJ, Crabb BS, Kirk K, Papenfuss AT, Cowman AF, Abbott BM. A 4-cyano-3-methylisoquinoline inhibitor of Plasmodium falciparum growth targets the sodium efflux pump PfATP4. Sci Rep. 2019 07 16; 9(1):10292. PMID: 31311978.
    Citations:    
  8. Healer J, Wong W, Thompson JK, He W, Birkinshaw RW, Miura K, Long CA, Soroka V, Søgaard TMM, Jørgensen T, de Jongh WA, Weir C, Svahn E, Czabotar PE, Tham WH, Mueller I, Barlow PN, Cowman AF. Neutralising antibodies block the function of Rh5/Ripr/CyRPA complex during invasion of Plasmodium falciparum into human erythrocytes. Cell Microbiol. 2019 07; 21(7):e13030. PMID: 30965383.
    Citations:    
  9. Schloetel JG, Heine J, Cowman AF, Pasternak M. Guided STED nanoscopy enables super-resolution imaging of blood stage malaria parasites. Sci Rep. 2019 03 18; 9(1):4674. PMID: 30886187.
    Citations:    
  10. Gilson PR, Nguyen W, Poole WA, Teixeira JE, Thompson JK, Guo K, Stewart RJ, Ashton TD, White KL, Sanz LM, Gamo FJ, Charman SA, Wittlin S, Duffy J, Tonkin CJ, Tham WH, Crabb BS, Cooke BM, Huston CD, Cowman AF, Sleebs BE. Evaluation of 4-Amino 2-Anilinoquinazolines against Plasmodium and Other Apicomplexan Parasites In Vitro and in a P. falciparum Humanized NOD-scid IL2R?null Mouse Model of Malaria. Antimicrob Agents Chemother. 2019 03; 63(3). PMID: 30559138.
    Citations:    Fields:    
  11. He WQ, Shakri AR, Bhardwaj R, França CT, Stanisic DI, Healer J, Kiniboro B, Robinson LJ, Guillotte-Blisnick M, Huon C, Siba P, Cowman A, King CL, Tham WH, Chitnis CE, Mueller I. Antibody responses to Plasmodium vivax Duffy binding and Erythrocyte binding proteins predict risk of infection and are associated with protection from clinical Malaria. PLoS Negl Trop Dis. 2019 02; 13(2):e0006987. PMID: 30768655.
    Citations:    
  12. Wong W, Huang R, Menant S, Hong C, Sandow JJ, Birkinshaw RW, Healer J, Hodder AN, Kanjee U, Tonkin CJ, Heckmann D, Soroka V, Søgaard TMM, Jørgensen T, Duraisingh MT, Czabotar PE, de Jongh WA, Tham WH, Webb AI, Yu Z, Cowman AF. Structure of Plasmodium falciparum Rh5-CyRPA-Ripr invasion complex. Nature. 2019 01; 565(7737):118-121. PMID: 30542156.
    Citations:    Fields:    
  13. Marapana DS, Dagley LF, Sandow JJ, Nebl T, Triglia T, Pasternak M, Dickerman BK, Crabb BS, Gilson PR, Webb AI, Boddey JA, Cowman AF. Plasmepsin V cleaves malaria effector proteins in a distinct endoplasmic reticulum translocation interactome for export to the erythrocyte. Nat Microbiol. 2018 09; 3(9):1010-1022. PMID: 30127496.
    Citations:    Fields:    
  14. Pawliw R, Farrow R, Sekuloski S, Jennings H, Healer J, Phuong T, Sathe P, Pasay C, Evans K, Cowman AF, Schofield L, Chen N, McCarthy J, Trenholme K. A bioreactor system for the manufacture of a genetically modified Plasmodium falciparum blood stage malaria cell bank for use in a clinical trial. Malar J. 2018 Aug 06; 17(1):283. PMID: 30081913.
    Citations:    Fields:    Translation:Animals
  15. Gruszczyk J, Huang RK, Chan LJ, Menant S, Hong C, Murphy JM, Mok YF, Griffin MDW, Pearson RD, Wong W, Cowman AF, Yu Z, Tham WH. Cryo-EM structure of an essential Plasmodium vivax invasion complex. Nature. 2018 07; 559(7712):135-139. PMID: 29950717.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  16. Nguyen W, Hodder AN, de Lezongard RB, Czabotar PE, Jarman KE, O'Neill MT, Thompson JK, Jousset Sabroux H, Cowman AF, Boddey JA, Sleebs BE. Enhanced antimalarial activity of plasmepsin V inhibitors by modification of the P2 position of PEXEL peptidomimetics. Eur J Med Chem. 2018 Jun 25; 154:182-198. PMID: 29800827.
    Citations:    Fields:    Translation:AnimalsCells
  17. Hallée S, Boddey JA, Cowman AF, Richard D. Evidence that the Plasmodium falciparum Protein Sortilin Potentially Acts as an Escorter for the Trafficking of the Rhoptry-Associated Membrane Antigen to the Rhoptries. mSphere. 2018 Jan-Feb; 3(1). PMID: 29299530.
    Citations: 1     
  18. Weber GE, White MT, Babakhanyan A, Sumba PO, Vulule J, Ely D, John C, Angov E, Lanar D, Dutta S, Narum DL, Horii T, Cowman A, Beeson J, Smith J, Kazura JW, Dent AE. Sero-catalytic and Antibody Acquisition Models to Estimate Differing Malaria Transmission Intensities in Western Kenya. Sci Rep. 2017 12 04; 7(1):16821. PMID: 29203846.
    Citations:    Fields:    
  19. França CT, White MT, He WQ, Hostetler JB, Brewster J, Frato G, Malhotra I, Gruszczyk J, Huon C, Lin E, Kiniboro B, Yadava A, Siba P, Galinski MR, Healer J, Chitnis C, Cowman AF, Takashima E, Tsuboi T, Tham WH, Fairhurst RM, Rayner JC, King CL, Mueller I. Identification of highly-protective combinations of Plasmodium vivax recombinant proteins for vaccine development. Elife. 2017 09 26; 6. PMID: 28949293.
    Citations: 2     Fields:    Translation:HumansAnimals