Harvard Catalyst Profiles

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Edy Yong Kim, M.D.,Ph.D.

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Biography
Harvard CollegeAB
Coro Fellow in Public Affairs
Washington Univ Saint LouisMD PhD
Brigham and Women's HospitalResidencyInternal Medicine
Harvard Combined, (MGH, BWH, BIDMC)FellowshipPulmonary and Critical Care
2010
1st place, 7th Annual Respiratory Disease Young Investigator Forum
2015
ReSS Young Investigator Award
2017
AAI Young Investigator Award
2018
AHA Cournand and Comroe Award Finalist
2019
BWH Innovation Evergreen Fund

Overview
I welcome any inquires regarding research rotations, RA or post-doctoral positions from candidates interested in the immunology of human disease, in particular those with bioinformatics experience. Bridging clinical data and biobanks, discovery platforms (e.g., single-cell RNASeq, lipidomics) and mechanistic studies is a strength of my lab.

Clinical interests: I attend in the Brigham and Women's Hospital Medical Intensive Care Unit (MICU) and the Pulmonary Fellows' Clinic.

Research interests: The Kim lab focuses on deep immunophenotyping of human disease via discovery platforms with validation in experimental models. In line with my clinical interests, we study cardiac arrest and resuscitation, post-sepsis immunosuppression, auto-immune pulmonary fibrosis (esp. RA-ILD) and immune checkpoint inhibitor (ICI) pneumonitis.

Translational: The Kim lab runs two clinical biobanks: The Cardiac Arrest Biobank and VATS (early lung disease biopsy) Biobank; we work closely with Dr. Osama Rahma on a ICI pneumonitis biobank.

Experimental: The Kim lab runs mouse models of cardiac arrest, sepsis and pulmonary fibrosis.

Pharma collaboration: The Kim lab works with Roche and Bayer to apply discovery platforms to human biobanks.

Academic collaboration: The Kim lab collaborates closely with laboratories across BWH (e.g., in Pulmonary, Cardiovascular Medicine, Renal, Rheumatology) and at other centers (e.g., Univ. Pittsburgh, Univ. of Toronto, BIDMC, MGH).

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. (Edy Kim) Dec 15, 2019 - Dec 14, 2020
    ATS Foundation
    NKT cell activation of mTOR drives post-sepsis immunosuppression
  2. 15FTF25080205 (Edy Kim) Jun 30, 2015 - Jun 30, 2020
    AHA
    NKT Cells Protect Against Brain Injury After Cardiac Arrest and Resuscitation
  3. R01HL123546 (Raby)
    NHLBI
    Functional Consequences of 17q12 polymorphisms in Asthma
    Role: Co-I

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Kim EY, Ner-Gaon H, Varon J, Cullen AM, Guo J, Choi J, Barragan-Bradford D, Higuera A, Pinilla-Vera M, Short SA, Arciniegas-Rubio A, Tamura T, Leaf DE, Baron RM, Shay T, Brenner MB. Post-sepsis immunosuppression depends on NKT cell regulation of mTOR/IFN-? in NK cells. J Clin Invest. 2020 May 11. PMID: 32154791.
    Citations:    
  2. Nagai J, Balestrieri B, Fanning LB, Kyin T, Cirka H, Lin J, Idzko M, Zech A, Kim EY, Brennan PJ, Boyce JA. P2Y6 signaling in alveolar macrophages prevents leukotriene-dependent type 2 allergic lung inflammation. J Clin Invest. 2019 12 02; 129(12):5169-5186. PMID: 31638598.
    Citations:    
  3. Chu SG, Villalba JA, Liang X, Xiong K, Tsoyi K, Ith B, Ayaub EA, Tatituri RV, Byers DE, Hsu FF, El-Chemaly S, Kim EY, Shi Y, Rosas IO. Palmitic Acid-Rich High-Fat Diet Exacerbates Experimental Pulmonary Fibrosis by Modulating Endoplasmic Reticulum Stress. Am J Respir Cell Mol Biol. 2019 12; 61(6):737-746. PMID: 31461627.
    Citations:    
  4. Lee PY, Nelson-Maney N, Huang Y, Levescot A, Wang Q, Wei K, Cunin P, Li Y, Lederer JA, Zhuang H, Han S, Kim EY, Reeves WH, Nigrovic PA. High-dimensional analysis reveals a pathogenic role of inflammatory monocytes in experimental diffuse alveolar hemorrhage. JCI Insight. 2019 Aug 08; 4(15). PMID: 31391335.
    Citations:    
  5. Cunin P, Lee PY, Kim E, Schmider AB, Cloutier N, Pare A, Gunzer M, Soberman RJ, Lacroix S, Boilard E, Lefort CT, Nigrovic PA. Differential attenuation of ß2 integrin-dependent and -independent neutrophil migration by Ly6G ligation. Blood Adv. 2019 02 12; 3(3):256-267. PMID: 30696624.
    Citations:    
  6. Yoshida H, Lareau CA, Ramirez RN, Rose SA, Maier B, Wroblewska A, Desland F, Chudnovskiy A, Mortha A, Dominguez C, Tellier J, Kim E, Dwyer D, Shinton S, Nabekura T, Qi Y, Yu B, Robinette M, Kim KW, Wagers A, Rhoads A, Nutt SL, Brown BD, Mostafavi S, Buenrostro JD, Benoist C. The cis-Regulatory Atlas of the Mouse Immune System. Cell. 2019 02 07; 176(4):897-912.e20. PMID: 30686579.
    Citations:    Fields:    
  7. Kim EY, Oldham WM. Innate T cells in the intensive care unit. Mol Immunol. 2019 01; 105:213-223. PMID: 30554082.
    Citations:    Fields:    
  8. Dwyer DF, Barrett NA, Austen KF. Expression profiling of constitutive mast cells reveals a unique identity within the immune system. Nat Immunol. 2016 Jul; 17(7):878-87. PMID: 27135604.
    Citations: 26     Fields:    Translation:AnimalsCells
  9. Kim EY, Lynch L, Brennan PJ, Cohen NR, Brenner MB. The transcriptional programs of iNKT cells. Semin Immunol. 2015 Feb; 27(1):26-32. PMID: 25841627.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  10. Robinette ML, Fuchs A, Cortez VS, Lee JS, Wang Y, Durum SK, Gilfillan S, Colonna M. Transcriptional programs define molecular characteristics of innate lymphoid cell classes and subsets. Nat Immunol. 2015 Mar; 16(3):306-17. PMID: 25621825.
    Citations: 127     Fields:    Translation:AnimalsCells
  11. Benoist C, Lanier L, Merad M, Mathis D. Consortium biology in immunology: the perspective from the Immunological Genome Project. Nat Rev Immunol. 2012 10; 12(10):734-40. PMID: 22955842.
    Citations: 13     Fields:    Translation:HumansAnimals
  12. Cohen NR, Tatituri RV, Rivera A, Watts GF, Kim EY, Chiba A, Fuchs BB, Mylonakis E, Besra GS, Levitz SM, Brigl M, Brenner MB. Innate recognition of cell wall ß-glucans drives invariant natural killer T cell responses against fungi. Cell Host Microbe. 2011 Nov 17; 10(5):437-50. PMID: 22100160.
    Citations: 41     Fields:    Translation:AnimalsCells
  13. Brennan PJ, Tatituri RV, Brigl M, Kim EY, Tuli A, Sanderson JP, Gadola SD, Hsu FF, Besra GS, Brenner MB. Invariant natural killer T cells recognize lipid self antigen induced by microbial danger signals. Nat Immunol. 2011 Oct 30; 12(12):1202-11. PMID: 22037601.
    Citations: 136     Fields:    Translation:HumansAnimalsCells
  14. Holtzman MJ, Byers DE, Benoit LA, Battaile JT, You Y, Agapov E, Park C, Grayson MH, Kim EY, Patel AC. Immune pathways for translating viral infection into chronic airway disease. Adv Immunol. 2009; 102:245-76. PMID: 19477323.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  15. Kim EY, Battaile JT, Patel AC, You Y, Agapov E, Grayson MH, Benoit LA, Byers DE, Alevy Y, Tucker J, Swanson S, Tidwell R, Tyner JW, Morton JD, Castro M, Polineni D, Patterson GA, Schwendener RA, Allard JD, Peltz G, Holtzman MJ. Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease. Nat Med. 2008 Jun; 14(6):633-40. PMID: 18488036.
    Citations: 189     Fields:    Translation:AnimalsCells
  16. Grayson MH, Cheung D, Rohlfing MM, Kitchens R, Spiegel DE, Tucker J, Battaile JT, Alevy Y, Yan L, Agapov E, Kim EY, Holtzman MJ. Induction of high-affinity IgE receptor on lung dendritic cells during viral infection leads to mucous cell metaplasia. J Exp Med. 2007 Oct 29; 204(11):2759-69. PMID: 17954569.
    Citations: 76     Fields:    Translation:AnimalsCells
  17. Patel AC, Morton JD, Kim EY, Alevy Y, Swanson S, Tucker J, Huang G, Agapov E, Phillips TE, Fuentes ME, Iglesias A, Aud D, Allard JD, Dabbagh K, Peltz G, Holtzman MJ. Genetic segregation of airway disease traits despite redundancy of calcium-activated chloride channel family members. Physiol Genomics. 2006 May 16; 25(3):502-13. PMID: 16569774.
    Citations: 37     Fields:    Translation:AnimalsCells
  18. Tyner JW, Kim EY, Ide K, Pelletier MR, Roswit WT, Morton JD, Battaile JT, Patel AC, Patterson GA, Castro M, Spoor MS, You Y, Brody SL, Holtzman MJ. Blocking airway mucous cell metaplasia by inhibiting EGFR antiapoptosis and IL-13 transdifferentiation signals. J Clin Invest. 2006 Feb; 116(2):309-21. PMID: 16453019.
    Citations: 93     Fields:    Translation:HumansAnimalsCells
  19. Tyner JW, Uchida O, Kajiwara N, Kim EY, Patel AC, O'Sullivan MP, Walter MJ, Schwendener RA, Cook DN, Danoff TM, Holtzman MJ. CCL5-CCR5 interaction provides antiapoptotic signals for macrophage survival during viral infection. Nat Med. 2005 Nov; 11(11):1180-7. PMID: 16208318.
    Citations: 90     Fields:    Translation:AnimalsCells
  20. Holtzman MJ, Kim EY, Lo MS, Tyner JW, Shornick LP, Sumino KC, Zhang Y. Defining and adjusting divergent host responses to viral infection. Immunol Res. 2005; 32(1-3):123-41. PMID: 16106064.
    Citations:    Fields:    Translation:HumansAnimalsCells
  21. Holtzman MJ, Tyner JW, Kim EY, Lo MS, Patel AC, Shornick LP, Agapov E, Zhang Y. Acute and chronic airway responses to viral infection: implications for asthma and chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2005; 2(2):132-40. PMID: 16113481.
    Citations: 19     Fields:    Translation:HumansAnimals
  22. Holtzman MJ, Shornick LP, Grayson MH, Kim EY, Tyner JW, Patel AC, Agapov E, Zhang Y. "Hit-and-run" effects of paramyxoviruses as a basis for chronic respiratory disease. Pediatr Infect Dis J. 2004 Nov; 23(11 Suppl):S235-45. PMID: 15577579.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  23. Holtzman MJ, Agapov E, Kim E, Kim JI, Morton JD. Developing the epithelial, viral, and allergic paradigm for asthma: Giles F. Filley lecture. Chest. 2003 Mar; 123(3 Suppl):377S-84S. PMID: 12628993.
    Citations:    Fields:    Translation:Humans
  24. Xu YJ, Kim EY, Demple B. Excision of C-4'-oxidized deoxyribose lesions from double-stranded DNA by human apurinic/apyrimidinic endonuclease (Ape1 protein) and DNA polymerase beta. J Biol Chem. 1998 Oct 30; 273(44):28837-44. PMID: 9786884.
    Citations: 25     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.