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Roeland Johannes Middelbeek, M.D.

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  1. K23DK114550 (MIDDELBEEK, ROELAND J) Apr 1, 2018 - Mar 31, 2023
    Mechanisms of exercise effects in obese humans: sex-specific regulation of novel adipose tissue function
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. White NH, Pan Q, Knowler WC, Schroeder EB, Dabelea D, Chew EY, Blodi B, Goldberg RB, Pi-Sunyer X, Darwin C, Schlögl M, Nathan DM. Risk Factors for the Development of Retinopathy in Prediabetes and Type 2 Diabetes: The Diabetes Prevention Program Experience. Diabetes Care. 2022 11 01; 45(11):2653-2661. PMID: 36098658; PMCID: PMC9679265.
    Citations: 1     Fields:    Translation:Humans
  2. Steenkamp DW, Piarulli A, Middelbeek RJW, Wolpert HA. Severe hypoglycaemia while using a hybrid closed-loop insulin pump system: A reminder of the continued importance of patient education for pre-emptive hypoglycaemia mitigation. Diabet Med. 2022 Oct 17; e14975. PMID: 36251520.
    Citations:    Fields:    
  3. Yang J, Vamvini M, Nigro P, Ho LL, Galani K, Alvarez M, Tanigawa Y, Renfro A, Carbone NP, Laakso M, Agudelo LZ, Pajukanta P, Hirshman MF, Middelbeek RJW, Grove K, Goodyear LJ, Kellis M. Single-cell dissection of the obesity-exercise axis in adipose-muscle tissues implies a critical role for mesenchymal stem cells. Cell Metab. 2022 10 04; 34(10):1578-1593.e6. PMID: 36198295; PMCID: PMC9558082.
    Citations:    Fields:    Translation:AnimalsCells
  4. Romeo GR, Shaikh YA, Middelbeek RJW. Post-graduate medical education in the time of COVID-19: Not a remotely simple task. Front Endocrinol (Lausanne). 2022; 13:980505. PMID: 36187134.
    Citations:    Fields:    Translation:HumansPHPublic Health
  5. Wing RR, Neiberg RH, Bahnson JL, Clark JM, Espeland MA, Hill JO, Johnson KC, Knowler WC, Olson K, Steinburg H, Pi-Sunyer X, Wadden TA, Wyatt H, Clark JM, Swartz L, Jiggetts D, Charleston J, Cheskin L, Maruthur NM, Pilla SJ, Diggins D, Johnson M, Bray GA, Greenway FL, Ryan DH, Champagne C, Myers V, Keller J, Stewart T, Arceneaux J, Boley K, Fry G, Jones L, Landry K, Lingle M, Smith M, Lewis CE, Thomas S, Glasser S, Dutton G, Dobelstein A, Hannum S, Hubbell A, Lee D, Millhouse P, Oden LC, Roche C, Grant J, Turman J, Nathan DM, Goldman V, Delahanty L, Larkin M, Dalton K, Singh R, Ruazol M, Munshi MN, Jackson SD, Middelbeek RJW, Caballero AE, Rodriguez A, Blackburn G, Mantzoros C, McNamara A, Wyatt H, Hill JO, Breen JA, Miller M, Bochert D, Bossart S, Cohrs P, Green S, Hamilton A, Leshchinskiy E, Rome L, Foreyt JP, Gee M, Pownall H, Balasubramanyam A, Chen CH, Jones P, Burrington M, Gardner AC, Griggs S, Hamilton M, Holley V, Lee S, Liscum SL, Cantu-Lumbreras S, Palencia J, Schmidt J, Thomas J, White C, Wright C, Alvarez M, Johnson KC, Griffin B, Coday M, Valenski D, Jones L, Johnson K, Johnson KC, Steinburg H, Jeffery RW, Skarphol T, Bantle JP, Redmon JB, Brelje K, Campbell C, Forseth MA, Uccellini S, Voeller MS, Laferrère B, Pi-Sunyer X, Patricio J, Luchsinger J, Palta P, Lyon S, Kelly K, Wadden TA, Maschak-Carey BJ, Berkowitz RI, Chao A, Davenport R, Gruber K, Leonard S, Walsh O, Jakicic JM, Wesche-Thobaben J, Ewing L, Hergenroeder A, Korytkowski M, Copelli S, Danchenko R, Ives D, Mancino J, Martich L, McGuire M, Murray TY, Semler L, Williams K, Wing RR, Egan C, Jelalian E, McCaffery J, McDermott KD, Unick J, Annis K, DaCruz J, Rafanelli A, Hazuda HP, Isaac JC, Hernandez P, Kahn SE, Boyko EJ, Tsai E, Wright L, Atkinson K, Morgan-Taggart I, Socha J, Urquhart H, Knowler WC, Bolin P, Anderson H, Michaels S, Johnson R, Poorthunder P, Smiley J, Peters AL, Ghazarian S, Beale E, Ramirez E, Rodriguez G, Ruelas V, Serafin-Dokhan S, Walker M, Perez M, Espeland MA, Wagenknecht LE, Bahnson JL, Reboussin D, Miller ME, Brubaker P, Pajewski N, Bancks M, Ding J, Deep G, Hayden K, Rapp SR, Simpson F, Chen H, Sachs BC, Houston D, Chen SH, Anderson A, Barnes JM, Barr M, Beckner TD, Cook DR, Williams CC, Evans J, Garcia K, Gaussoin SA, Kittel C, Harvin L, Howard M, Lovato J, Neiberg RH, Pierce J, Steinberg D, Webb C, Walker J, Walkup MP, Watkins C, Marcovina SM, Hurting J, Albers JJ, Gaur V, Nevitt M, Schwartz A, Shepherd J, Rahorst M, Palermo L, Ewing S, Hayashi C, Maeda J. Weight Change During the Postintervention Follow-up of Look AHEAD. Diabetes Care. 2022 Apr 14. PMID: 35421225; PMCID: PMC9277114.
    Citations:    Fields:    
  6. Lee CG, Heckman-Stoddard B, Dabelea D, Gadde KM, Ehrmann D, Ford L, Prorok P, Boyko EJ, Pi-Sunyer X, Wallia A, Knowler WC, Crandall JP, Temprosa M. Effect of Metformin and Lifestyle Interventions on Mortality in the Diabetes Prevention Program and Diabetes Prevention Program Outcomes Study. Diabetes Care. 2021 12; 44(12):2775-2782. PMID: 34697033; PMCID: PMC8669534.
    Citations: 6     Fields:    Translation:Humans
  7. Wadden TA, Chao AM, Anderson H, Annis K, Atkinson K, Bolin P, Brantley P, Clark JM, Coday M, Dutton G, Foreyt JP, W Gregg E, Hazuda HP, Hill JO, Hubbard VS, Jakicic JM, Jeffery RW, Johnson KC, Kahn SE, Knowler WC, Korytkowski M, Lewis CE, Laferrère B, Middelbeek RJ, Munshi MN, Nathan DM, Neiberg RH, Pilla SJ, Peters A, Pi-Sunyer X, Rejeski JW, Redmon B, Stewart T, Vaughan E, Wagenknecht LE, Walkup MP, Wing RR, Wyatt H, Yanovski SZ, Zhang P. Changes in mood and health-related quality of life in Look AHEAD 6 years after termination of the lifestyle intervention. Obesity (Silver Spring). 2021 08; 29(8):1294-1308. PMID: 34258889; PMCID: PMC8903054.
    Citations: 2     Fields:    Translation:Humans
  8. Kusuyama J, Alves-Wagner AB, Conlin RH, Makarewicz NS, Albertson BG, Prince NB, Kobayashi S, Kozuka C, Møller M, Bjerre M, Fuglsang J, Miele E, Middelbeek RJW, Xiudong Y, Xia Y, Garneau L, Bhattacharjee J, Aguer C, Patti ME, Hirshman MF, Jessen N, Hatta T, Ovesen PG, Adamo KB, Nozik-Grayck E, Goodyear LJ. Placental superoxide dismutase 3 mediates benefits of maternal exercise on offspring health. Cell Metab. 2021 05 04; 33(5):939-956.e8. PMID: 33770509; PMCID: PMC8103776.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  9. Qian J, Walkup MP, Chen SH, Brubaker PH, Bond DS, Richey PA, Jakicic JM, Hu K, Scheer FAJL, Middelbeek RJW. Association of Objectively Measured Timing of Physical Activity Bouts With Cardiovascular Health in Type 2 Diabetes. Diabetes Care. 2021 04; 44(4):1046-1054. PMID: 33597215; PMCID: PMC7985432.
    Citations: 2     Fields:    Translation:Humans
  10. Nigro P, Middelbeek RJW, Alves CRR, Rovira-Llopis S, Ramachandran K, Rowland LA, Møller AB, Takahashi H, Alves-Wagner AB, Vamvini M, Makarewicz NS, Albertson BG, Hirshman MF, Goodyear LJ. Exercise Training Promotes Sex-Specific Adaptations in Mouse Inguinal White Adipose Tissue. Diabetes. 2021 06; 70(6):1250-1264. PMID: 33563587; PMCID: PMC8275891.
    Citations: 3     Fields:    Translation:AnimalsCells
  11. Middelbeek RJW, Motiani P, Brandt N, Nigro P, Zheng J, Virtanen KA, Kalliokoski KK, Hannukainen JC, Goodyear LJ. Exercise intensity regulates cytokine and klotho responses in men. Nutr Diabetes. 2021 01 07; 11(1):5. PMID: 33414377; PMCID: PMC7791135.
    Citations: 9     Fields:    Translation:Humans
  12. Unick JL, Walkup MP, Miller ME, Apolzan JW, Brubaker PH, Coday M, Hill JO, Jakicic JM, Middelbeek RJW, West D, Wing RR. Early Physical Activity Adoption Predicts Longer-Term Physical Activity Among Individuals Inactive at Baseline. J Phys Act Health. 2020 11 03; 17(12):1205-1212. PMID: 33152692; PMCID: PMC9159534.
    Citations: 2     Fields:    Translation:Humans
  13. Vamvini M, Lioutas VA, Middelbeek RJW. Characteristics and Diabetes Control in Adults With Type 1 Diabetes Admitted With COVID-19 Infection. Diabetes Care. 2020 10; 43(10):e120-e122. PMID: 32769127.
    Citations: 7     Fields:    Translation:HumansCellsPHPublic Health
  14. Jakicic JM, Horton ES, Curtis JM, Killean TM, Bray GA, Cheskin LJ, Johnson KC, Middelbeek RJW, Pi-Sunyer FX, Regensteiner JG, Ribisl PM, Wagenknecht L, Espeland MA. Abnormal Exercise Test or CVD History on Weight Loss or Fitness: the Look AHEAD Trial. Transl J Am Coll Sports Med. 2020; 5(12). PMID: 34017914; PMCID: PMC8130141.
  15. Motiani P, Teuho J, Saari T, Virtanen KA, Honkala SM, Middelbeek RJ, Goodyear LJ, Eskola O, Andersson J, Löyttyniemi E, Hannukainen JC, Nuutila P. Exercise training alters lipoprotein particles independent of brown adipose tissue metabolic activity. Obes Sci Pract. 2019 Jun; 5(3):258-272. PMID: 31275600; PMCID: PMC6587322.
    Citations: 3     
  16. Takahashi H, Alves CRR, Stanford KI, Middelbeek RJW, Nigro P, Ryan RE, Xue R, Sakaguchi M, Lynes MD, So K, Mul JD, Lee MY, Balan E, Pan H, Dreyfuss JM, Hirshman MF, Azhar M, Hannukainen JC, Nuutila P, Kalliokoski KK, Nielsen S, Pedersen BK, Kahn CR, Tseng YH, Goodyear LJ. TGF-ß2 is an exercise-induced adipokine that regulates glucose and fatty acid metabolism. Nat Metab. 2019 02; 1(2):291-303. PMID: 31032475; PMCID: PMC6481955.
    Citations: 50     Fields:    Translation:Animals
  17. Stanford KI, Lynes MD, Takahashi H, Baer LA, Arts PJ, May FJ, Lehnig AC, Middelbeek RJW, Richard JJ, So K, Chen EY, Gao F, Narain NR, Distefano G, Shettigar VK, Hirshman MF, Ziolo MT, Kiebish MA, Tseng YH, Coen PM, Goodyear LJ. 12,13-diHOME: An Exercise-Induced Lipokine that Increases Skeletal Muscle Fatty Acid Uptake. Cell Metab. 2018 Jun 05; 27(6):1357. PMID: 29874569; PMCID: PMC5993199.
    Citations: 12     Fields:    
  18. Stanford KI, Lynes MD, Takahashi H, Baer LA, Arts PJ, May FJ, Lehnig AC, Middelbeek RJW, Richard JJ, So K, Chen EY, Gao F, Narain NR, Distefano G, Shettigar VK, Hirshman MF, Ziolo MT, Kiebish MA, Tseng YH, Coen PM, Goodyear LJ. 12,13-diHOME: An Exercise-Induced Lipokine that Increases Skeletal Muscle Fatty Acid Uptake. Cell Metab. 2018 May 01; 27(5):1111-1120.e3. PMID: 29719226; PMCID: PMC5935136.
    Citations: 76     Fields:    Translation:HumansAnimalsCells
  19. Mulla CM, Middelbeek RJW, Patti ME. Mechanisms of weight loss and improved metabolism following bariatric surgery. Ann N Y Acad Sci. 2018 01; 1411(1):53-64. PMID: 28868615; PMCID: PMC5788713.
    Citations: 38     Fields:    Translation:Humans
  20. Motiani P, Virtanen KA, Motiani KK, Eskelinen JJ, Middelbeek RJ, Goodyear LJ, Savolainen AM, Kemppainen J, Jensen J, Din MU, Saunavaara V, Parkkola R, Löyttyniemi E, Knuuti J, Nuutila P, Kalliokoski KK, Hannukainen JC. Decreased insulin-stimulated brown adipose tissue glucose uptake after short-term exercise training in healthy middle-aged men. Diabetes Obes Metab. 2017 10; 19(10):1379-1388. PMID: 28318098.
    Citations: 23     Fields:    Translation:Humans
  21. Middelbeek RJW, O'Neill BT, Nishino M, Pallotta JA. Concurrent Intrathyroidal Thyroid Cancer and Thyroid Cancer in Struma Ovarii: A Case Report and Literature Review. J Endocr Soc. 2017 May 01; 1(5):396-400. PMID: 29264493; PMCID: PMC5686688.
    Citations: 4     
  22. Middelbeek RJ, Brown FM, Patti ME. Weight Loss and Health Status after Bariatric Surgery in Adolescents. N Engl J Med. 2016 05 19; 374(20):1988-9. PMID: 27192680.
    Citations:    Fields:    Translation:Humans
  23. Middelbeek RJ, Veuger SA. Letter Regarding Maryland Alcohol Sales Tax and Sexually Transmitted Infections. Am J Prev Med. 2016 May; 50(5):e159. PMID: 27102643.
    Citations:    Fields:    Translation:Humans
  24. Stanford KI, Middelbeek RJ, Goodyear LJ. Erratum. Exercise Effects on White Adipose Tissue: Beiging and Metabolic Adaptations. Diabetes 2015;64:2361-2368. Diabetes. 2015 Sep; 64(9):3334. PMID: 26294430.
    Citations: 2     Fields:    
  25. Middelbeek RJ, James-Todd T, Cavallerano JD, Schlossman DK, Patti ME, Brown FM. Gastric Bypass Surgery in Severely Obese Women With Type 1 Diabetes: Anthropometric and Cardiometabolic Effects at 1 and 5 Years Postsurgery. Diabetes Care. 2015 Jul; 38(7):e104-5. PMID: 26106230.
    Citations: 8     Fields:    
  26. Stanford KI, Middelbeek RJ, Goodyear LJ. Exercise Effects on White Adipose Tissue: Beiging and Metabolic Adaptations. Diabetes. 2015 Jul; 64(7):2361-8. PMID: 26050668; PMCID: PMC4477356.
    Citations: 124     Fields:    Translation:HumansAnimalsCells
  27. Middelbeek RJ, Veuger SA. Letter to the Editor: Re: Neurobehavioral Deficits, Diseases, and Associated Costs of Exposure to Endocrine-Disrupting Chemicals in the European Union. J Clin Endocrinol Metab. 2015 Jun; 100(6):L52-3. PMID: 26047084; PMCID: PMC5393516.
    Citations: 2     Fields:    Translation:HumansPHPublic Health
  28. Stanford KI, Middelbeek RJ, Townsend KL, Lee MY, Takahashi H, So K, Hitchcox KM, Markan KR, Hellbach K, Hirshman MF, Tseng YH, Goodyear LJ. A novel role for subcutaneous adipose tissue in exercise-induced improvements in glucose homeostasis. Diabetes. 2015 Jun; 64(6):2002-14. PMID: 25605808; PMCID: PMC4439563.
    Citations: 135     Fields:    Translation:Animals
  29. Middelbeek RJ, Brown FM. Comment on Brethauer et al. Bariatric surgery improves the metabolic profile of morbidly obese patients with type 1 diabetes. Diabetes care 2014;37:e51-e52. Diabetes Care. 2014 Nov; 37(11):e250. PMID: 25342845.
    Citations: 2     Fields:    Translation:Humans
  30. Middelbeek RJ, James-Todd T, Patti ME, Brown FM. Short-term insulin requirements following gastric bypass surgery in severely obese women with type 1 diabetes. Obes Surg. 2014 Sep; 24(9):1442-6. PMID: 24668543.
    Citations: 14     Fields:    Translation:Humans
  31. Middelbeek RJ, Abrahamson MJ. Diabetes, prediabetes, and glycemic control in the United States: challenges and opportunities. Ann Intern Med. 2014 Apr 15; 160(8):572-3. PMID: 24733201.
    Citations: 3     Fields:    Translation:Humans
  32. Middelbeek RJ, Chambers MA, Tantiwong P, Treebak JT, An D, Hirshman MF, Musi N, Goodyear LJ. Insulin stimulation regulates AS160 and TBC1D1 phosphorylation sites in human skeletal muscle. Nutr Diabetes. 2013 Jun 10; 3:e74. PMID: 23752133.
    Citations: 18     Fields:    
  33. Stanford KI, Middelbeek RJ, Townsend KL, An D, Nygaard EB, Hitchcox KM, Markan KR, Nakano K, Hirshman MF, Tseng YH, Goodyear LJ. Brown adipose tissue regulates glucose homeostasis and insulin sensitivity. J Clin Invest. 2013 Jan; 123(1):215-23. PMID: 23221344; PMCID: PMC3533266.
    Citations: 446     Fields:    Translation:Animals
  34. Koh HJ, Toyoda T, Fujii N, Jung MM, Rathod A, Middelbeek RJ, Lessard SJ, Treebak JT, Tsuchihara K, Esumi H, Richter EA, Wojtaszewski JF, Hirshman MF, Goodyear LJ. Sucrose nonfermenting AMPK-related kinase (SNARK) mediates contraction-stimulated glucose transport in mouse skeletal muscle. Proc Natl Acad Sci U S A. 2010 Aug 31; 107(35):15541-6. PMID: 20713714; PMCID: PMC2932588.
    Citations: 49     Fields:    Translation:HumansAnimalsCells
  35. Middelbeek RJ, Horton ES. The role of glucose as an independent cardiovascular risk factor. Curr Diab Rep. 2007 Feb; 7(1):43-9. PMID: 17254517.
    Citations: 3     Fields:    Translation:Humans
  36. Al-Ozairi E, Middelbeek RJ, Horton ES. Cardiovascular risk assessment in type 2 diabetes mellitus. Curr Diab Rep. 2006 Nov; 6(5):333-6. PMID: 17076992.
    Citations:    Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.