Harvard Catalyst Profiles

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Caroline Ann Owen, PH.D., M.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. (Owen CA) Jul 1, 2016 - Jan 31, 2018
    Department of Defense
    B cells in Acute Lung Injury
  2. R21ES025379 (FEDULOV, ALEXEY V) Jun 15, 2015 - May 31, 2017
    Epigenetic reactivation of human club cell protein 16 in COPD
    Role: Co-Investigator
  3. R01HL127200 (ZHOU, ANNY XIAOBO) Apr 1, 2015 - Mar 31, 2020
    HL-FAM13A Regulates the beta-catenin/Wnt Pathway in Chronic Obstructive Pulmonary Disease
    Role: Co-Investigator
  4. RO1AI111475 (Owen, Caroline) Apr 1, 2014 - Mar 31, 2019
    Targeting MMP-9 to improve outcomes in serious influenza viral infections
    Role: Principal Investigator
  5. P01HL114501 (CHOI, AUGUSTINE M) Sep 6, 2013 - Jun 30, 2018
    Distinct and Overlapping Pathways of Fibrosis and Emphysema in Cigarette Smokers
    Role: Co-Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Polverino F, Lu B, Quintero JR, Vargas SO, Patel AS, Owen CA, Gerard NP, Gerard C, Cernadas M. CFTR regulates B cell activation and lymphoid follicle development. Respir Res. 2019 Jul 01; 20(1):133. PMID: 31262295.
  2. Walker S, Flume P, McNamara J, Solomon M, Chilvers M, Chmiel J, Harris RS, Haseltine E, Stiles D, Li C, Ahluwalia N, Zhou H, Owen CA, Sawicki G. A phase 3 study of tezacaftor in combination with ivacaftor in children aged 6 through 11?years with cystic fibrosis. J Cyst Fibros. 2019 Jun 25. PMID: 31253540.
  3. Wang X, Rojas-Quintero J, Wilder J, Tesfaigzi Y, Zhang D, Owen CA. Tissue Inhibitor of Metalloproteinase-1 Promotes Polymorphonuclear Neutrophil (PMN) Pericellular Proteolysis by Anchoring Matrix Metalloproteinase-8 and -9 to PMN Surfaces. J Immunol. 2019 Jun 01; 202(11):3267-3281. PMID: 31019060.
  4. Wang X, Rojas-Quintero J, Owen CA. To Bet or Not To Bet on T-Bet As A Therapeutic Target in Emphysema? Am J Respir Cell Mol Biol. 2019 Apr 15. PMID: 30986358.
  5. Morrow JD, Chase RP, Parker MM, Glass K, Seo M, Divo M, Owen CA, Castaldi P, DeMeo DL, Silverman EK, Hersh CP. RNA-sequencing across three matched tissues reveals shared and tissue-specific gene expression and pathway signatures of COPD. Respir Res. 2019 Apr 02; 20(1):65. PMID: 30940135.
  6. Bazzone LE, King M, MacKay CR, Kyawe PP, Meraner P, Lindstrom D, Rojas-Quintero J, Owen CA, Wang JP, Brass AL, Kurt-Jones EA, Finberg RW. A Disintegrin and Metalloproteinase 9 Domain (ADAM9) Is a Major Susceptibility Factor in the Early Stages of Encephalomyocarditis Virus Infection. MBio. 2019 02 05; 10(1). PMID: 30723129.
  7. Zhai J, Insel M, Addison KJ, Stern DA, Pederson W, Dy A, Rojas-Quintero J, Owen CA, Sherrill DL, Morgan W, Wright AL, Halonen M, Martinez FD, Kraft M, Guerra S, Ledford JG. Club Cell Secretory Protein Deficiency Leads to Altered Lung Function. Am J Respir Crit Care Med. 2019 Feb 01; 199(3):302-312. PMID: 30543455.
    Citations:    Fields:    
  8. Rojas-Quintero J, Wang X, Owen CA. Dusting Off IL-9 as a New Therapeutic Target for Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2019 Feb; 60(2):141-143. PMID: 30281328.
    Citations:    Fields:    
  9. McNamara JJ, McColley SA, Marigowda G, Liu F, Tian S, Owen CA, Stiles D, Li C, Waltz D, Wang LT, Sawicki GS. Safety, pharmacokinetics, and pharmacodynamics of lumacaftor and ivacaftor combination therapy in children aged 2-5 years with cystic fibrosis homozygous for F508del-CFTR: an open-label phase 3 study. Lancet Respir Med. 2019 Apr; 7(4):325-335. PMID: 30686767.
    Citations:    Fields:    
  10. Rojas-Quintero J, Wang X, Tipper J, Burkett PR, Zuñiga J, Ashtekar AR, Polverino F, Rout A, Yambayev I, Hernández C, Jimenez L, Ramírez G, Harrod KS, Owen CA. Matrix metalloproteinase-9 deficiency protects mice from severe influenza A viral infection. JCI Insight. 2018 12 20; 3(24). PMID: 30568032.
    Citations:    Fields:    
  11. Tesfaigzi Y, Petersen H, Celli B, Owen C. Functional Studies of Single-Nucleotide Polymorphisms Suggest Heterogeneity in Chronic Obstructive Pulmonary Disease due to Susceptibility of Different Cell Types. Ann Am Thorac Soc. 2018 Dec; 15(Supplement_4):S285. PMID: 30759009.
  12. Ryter SW, Rosas IO, Owen CA, Martinez FJ, Choi ME, Lee CG, Elias JA, Choi AMK. Mitochondrial Dysfunction as a Pathogenic Mediator of Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis. Ann Am Thorac Soc. 2018 Dec; 15(Supplement_4):S266-S272. PMID: 30759019.
  13. Petersen H, Sood A, Polverino F, Owen CA, Pinto-Plata V, Celli BR, Tesfaigzi Y. The Course of Lung Function in Middle-aged Heavy Smokers: Incidence and Time to Early Onset of Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2018 Dec 01; 198(11):1449-1451. PMID: 30114375.
    Citations:    Fields:    
  14. Liang X, Gupta K, Quintero JR, Cernadas M, Kobzik L, Christou H, Pier GB, Owen CA, Çataltepe S. Macrophage FABP4 is required for neutrophil recruitment and bacterial clearance in Pseudomonas aeruginosa pneumonia. FASEB J. 2019 Mar; 33(3):3562-3574. PMID: 30462529.
    Citations:    Fields:    
  15. Polverino F, Rojas-Quintero J, Wang X, Petersen H, Zhang L, Gai X, Higham A, Zhang D, Gupta K, Rout A, Yambayev I, Pinto-Plata V, Sholl LM, Cunoosamy D, Celli BR, Goldring J, Singh D, Tesfaigzi Y, Wedzicha J, Olsson H, Owen CA. A Disintegrin and Metalloproteinase Domain-8: A Novel Protective Proteinase in Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2018 Nov 15; 198(10):1254-1267. PMID: 29750543.
    Citations:    Fields:    
  16. Pabón MA, Patino E, Bhatia D, Rojas-Quintero J, Ma KC, Finkelsztein EJ, Osorio JC, Malick F, Polverino F, Owen CA, Ryter SW, Choi AM, Cloonan SM, Choi ME. Beclin-1 regulates cigarette smoke-induced kidney injury in a murine model of chronic obstructive pulmonary disease. JCI Insight. 2018 Sep 20; 3(18). PMID: 30232271.
    Citations:    Fields:    
  17. Laucho-Contreras ME, Polverino F, Rojas-Quintero J, Wang X, Owen CA. Club cell protein 16 (Cc16) deficiency increases inflamm-aging in the lungs of mice. Physiol Rep. 2018 08; 6(15):e13797. PMID: 30084231.
    Citations:    Fields:    
  18. Wang X, Polverino F, Rojas-Quintero J, Zhang D, Sánchez J, Yambayev I, Lindqvist E, Virtala R, Djukanovic R, Davies DE, Wilson S, O'Donnell R, Cunoosamy D, Hazon P, Higham A, Singh D, Olsson H, Owen CA. A Disintegrin and A Metalloproteinase-9 (ADAM9): A Novel Proteinase Culprit with Multifarious Contributions to COPD. Am J Respir Crit Care Med. 2018 Jun 04. PMID: 29864380.
    Citations:    Fields:    
  19. Celli BR, Locantore N, Tal-Singer R, Riley J, Miller B, Vestbo J, Yates JC, Silverman EK, Owen CA, Divo M, Pinto-Plata V, Wouters EFM, Faner R, Agusti A. Emphysema and extrapulmonary tissue loss in COPD: a multi-organ loss of tissue phenotype. Eur Respir J. 2018 02; 51(2). PMID: 29437944.
  20. Polverino F, Celli BR, Owen CA. Reply to Voelkel: Cigarette Smoke Is an Endothelial Cell Toxin. Am J Respir Crit Care Med. 2018 01 15; 197(2):274-275. PMID: 28726486.
    Citations: 1     Fields:    
  21. Polverino F, Celli BR, Owen CA. COPD as an endothelial disorder: endothelial injury linking lesions in the lungs and other organs? (2017 Grover Conference Series). Pulm Circ. 2018 Jan-Mar; 8(1):2045894018758528. PMID: 29468936.
    Citations: 3     
  22. Polverino F, Celli BR, Owen CA. Chronic Obstructive Pulmonary Disease: Breathing New Life into Old Cardiovascular Drugs? Ann Am Thorac Soc. 2017 11; 14(11):1718. PMID: 28950067.
    Citations:    Fields:    
  23. Yun JH, Morrow J, Owen CA, Qiu W, Glass K, Lao T, Jiang Z, Perrella MA, Silverman EK, Zhou X, Hersh CP. Transcriptomic Analysis of Lung Tissue from Cigarette Smoke-Induced Emphysema Murine Models and Human Chronic Obstructive Pulmonary Disease Show Shared and Distinct Pathways. Am J Respir Cell Mol Biol. 2017 07; 57(1):47-58. PMID: 28248572.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  24. Polverino F, Laucho-Contreras ME, Petersen H, Bijol V, Sholl LM, Choi ME, Divo M, Pinto-Plata V, Chetta A, Tesfaigzi Y, Celli BR, Owen CA. A Pilot Study Linking Endothelial Injury in Lungs and Kidneys in Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2017 06 01; 195(11):1464-1476. PMID: 28085500.
    Citations: 9     Fields:    Translation:HumansAnimals
  25. Wan ES, Li Y, Lao T, Qiu W, Jiang Z, Mancini JD, Owen CA, Clish C, DeMeo DL, Silverman EK, Zhou X. Metabolomic profiling in a Hedgehog Interacting Protein (Hhip) murine model of chronic obstructive pulmonary disease. Sci Rep. 2017 05 31; 7(1):2504. PMID: 28566717.
  26. Almeida-Reis R, Theodoro-Junior OA, Oliveira BTM, Oliva LV, Toledo-Arruda AC, Bonturi CR, Brito MV, Lopes FDTQS, Prado CM, Florencio AC, Martins MA, Owen CA, Leick EA, Oliva MLV, Tibério IFLC. Plant Proteinase Inhibitor BbCI Modulates Lung Inflammatory Responses and Mechanic and Remodeling Alterations Induced by Elastase in Mice. Biomed Res Int. 2017; 2017:8287125. PMID: 28466019.
    Citations: 2     Fields:    Translation:HumansAnimals
  27. Nakajima T, Nakamura H, Owen CA, Yoshida S, Tsuduki K, Chubachi S, Shirahata T, Mashimo S, Nakamura M, Takahashi S, Minematsu N, Tateno H, Fujishima S, Asano K, Celli BR, Betsuyaku T. Plasma Cathepsin S and Cathepsin S/Cystatin C Ratios Are Potential Biomarkers for COPD. Dis Markers. 2016; 2016:4093870. PMID: 27994288.
    Citations: 3     Fields:    Translation:Humans
  28. Polverino F, Seys LJ, Bracke KR, Owen CA. B cells in chronic obstructive pulmonary disease: moving to center stage. Am J Physiol Lung Cell Mol Physiol. 2016 Oct 01; 311(4):L687-L695. PMID: 27542809.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  29. Lao T, Jiang Z, Yun J, Qiu W, Guo F, Huang C, Mancini JD, Gupta K, Laucho-Contreras ME, Naing ZZ, Zhang L, Perrella MA, Owen CA, Silverman EK, Zhou X. Hhip haploinsufficiency sensitizes mice to age-related emphysema. Proc Natl Acad Sci U S A. 2016 08 09; 113(32):E4681-7. PMID: 27444019.
    Citations: 7     Fields:    Translation:Animals
  30. Jiang Z, Lao T, Qiu W, Polverino F, Gupta K, Guo F, Mancini JD, Naing ZZ, Cho MH, Castaldi PJ, Sun Y, Yu J, Laucho-Contreras ME, Kobzik L, Raby BA, Choi AM, Perrella MA, Owen CA, Silverman EK, Zhou X. A Chronic Obstructive Pulmonary Disease Susceptibility Gene, FAM13A, Regulates Protein Stability of ß-Catenin. Am J Respir Crit Care Med. 2016 07 15; 194(2):185-97. PMID: 26862784.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  31. Desoubeaux G, Reichert JM, Sleeman M, Reckamp KL, Ryffel B, Adamczewski JP, Sweeney TD, Vanbever R, Diot P, Owen CA, Page C, Lerondel S, Le Pape A, Heuze-Vourc'h N. Therapeutic monoclonal antibodies for respiratory diseases: Current challenges and perspectives, March 31 - April 1, 2016, Tours, France. MAbs. 2016 Aug-Sep; 8(6):999-1009. PMID: 27266390.
    Citations:    Fields:    Translation:Humans
  32. Polverino F, Laucho-Contreras M, Rojas Quintero J, Divo M, Pinto-Plata V, Sholl L, de-Torres JP, Celli BR, Owen CA. Increased expression of A Proliferation-inducing Ligand (APRIL) in lung leukocytes and alveolar epithelial cells in COPD patients with non small cell lung cancer: a possible link between COPD and lung cancer? Multidiscip Respir Med. 2016; 11:17. PMID: 27047662.
    Citations: 2     
  33. Laucho-Contreras ME, Polverino F, Tesfaigzi Y, Pilon A, Celli BR, Owen CA. Club Cell Protein 16 (CC16) Augmentation: A Potential Disease-modifying Approach for Chronic Obstructive Pulmonary Disease (COPD). Expert Opin Ther Targets. 2016 Jul; 20(7):869-83. PMID: 26781659.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  34. Cloonan SM, Glass K, Laucho-Contreras ME, Bhashyam AR, Cervo M, Pabón MA, Konrad C, Polverino F, Siempos II, Perez E, Mizumura K, Ghosh MC, Parameswaran H, Williams NC, Rooney KT, Chen ZH, Goldklang MP, Yuan GC, Moore SC, Demeo DL, Rouault TA, D'Armiento JM, Schon EA, Manfredi G, Quackenbush J, Mahmood A, Silverman EK, Owen CA, Choi AM. Mitochondrial iron chelation ameliorates cigarette smoke-induced bronchitis and emphysema in mice. Nat Med. 2016 Feb; 22(2):163-74. PMID: 26752519.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  35. Laucho-Contreras M, de Oca MM, Owen CA. Asthma COPD Overlap Syndrome: An Approach to A Real -World Endotype in Obstructive Lung Disease? Curr Pharm Des. 2016; 22(41):6273-6282. PMID: 27604607.
    Citations:    Fields:    Translation:Humans
  36. Craig VJ, Zhang L, Hagood JS, Owen CA. Matrix metalloproteinases as therapeutic targets for idiopathic pulmonary fibrosis. Am J Respir Cell Mol Biol. 2015 Nov; 53(5):585-600. PMID: 26121236.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  37. Polverino F, Cosio BG, Pons J, Laucho-Contreras M, Tejera P, Iglesias A, Rios A, Jahn A, Sauleda J, Divo M, Pinto-Plata V, Sholl L, Rosas IO, Agustí A, Celli BR, Owen CA. B Cell-Activating Factor. An Orchestrator of Lymphoid Follicles in Severe Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2015 Sep 15; 192(6):695-705. PMID: 26073875.
    Citations: 19     Fields:    Translation:HumansCells
  38. Lange P, Celli B, Agustí A, Boje Jensen G, Divo M, Faner R, Guerra S, Marott JL, Martinez FD, Martinez-Camblor P, Meek P, Owen CA, Petersen H, Pinto-Plata V, Schnohr P, Sood A, Soriano JB, Tesfaigzi Y, Vestbo J. Lung-Function Trajectories Leading to Chronic Obstructive Pulmonary Disease. N Engl J Med. 2015 Jul 09; 373(2):111-22. PMID: 26154786.
    Citations: 80     Fields:    Translation:Humans
  39. Petersen H, Leng S, Belinsky SA, Miller BE, Tal-Singer R, Owen CA, Celli B, Tesfaigzi Y. Low plasma CC16 levels in smokers are associated with a higher risk for chronic bronchitis. Eur Respir J. 2015 Nov; 46(5):1501-3. PMID: 26160869.
    Citations: 5     Fields:    Translation:Humans
  40. Laucho-Contreras ME, Polverino F, Gupta K, Taylor KL, Kelly E, Pinto-Plata V, Divo M, Ashfaq N, Petersen H, Stripp B, Pilon AL, Tesfaigzi Y, Celli BR, Owen CA. Protective role for club cell secretory protein-16 (CC16) in the development of COPD. Eur Respir J. 2015 Jun; 45(6):1544-56. PMID: 25700379.
    Citations: 18     Fields:    Translation:HumansAnimals
  41. Lao T, Glass K, Qiu W, Polverino F, Gupta K, Morrow J, Mancini JD, Vuong L, Perrella MA, Hersh CP, Owen CA, Quackenbush J, Yuan GC, Silverman EK, Zhou X. Haploinsufficiency of Hedgehog interacting protein causes increased emphysema induced by cigarette smoke through network rewiring. Genome Med. 2015; 7(1):12. PMID: 25763110.
    Citations: 12     Fields:    
  42. Laucho-Contreras ME, Taylor KL, Mahadeva R, Boukedes SS, Owen CA. Automated measurement of pulmonary emphysema and small airway remodeling in cigarette smoke-exposed mice. J Vis Exp. 2015 Jan 16; (95):52236. PMID: 25651034.
    Citations: 11     Fields:    Translation:Animals
  43. Polverino F, Doyle-Eisele M, McDonald J, Wilder JA, Royer C, Laucho-Contreras M, Kelly EM, Divo M, Pinto-Plata V, Mauderly J, Celli BR, Tesfaigzi Y, Owen CA. A novel nonhuman primate model of cigarette smoke-induced airway disease. Am J Pathol. 2015 Mar; 185(3):741-55. PMID: 25542772.
    Citations: 13     Fields:    Translation:Animals
  44. Tejera P, O'Mahony DS, Owen CA, Wei Y, Wang Z, Gupta K, Su L, Villar J, Wurfel M, Christiani DC. Functional characterization of polymorphisms in the peptidase inhibitor 3 (elafin) gene and validation of their contribution to risk of acute respiratory distress syndrome. Am J Respir Cell Mol Biol. 2014 Aug; 51(2):262-72. PMID: 24617927.
    Citations: 4     Fields:    Translation:HumansCells
  45. Khabibullin D, Medvetz DA, Pinilla M, Hariharan V, Li C, Hergrueter A, Laucho Contreras M, Zhang E, Parkhitko A, Yu JJ, Owen CA, Huang H, Baron RM, Henske EP. Folliculin regulates cell-cell adhesion, AMPK, and mTORC1 in a cell-type-specific manner in lung-derived cells. Physiol Rep. 2014 Aug 01; 2(8). PMID: 25121506.
    Citations: 10     Fields:    
  46. Mizumura K, Cloonan SM, Nakahira K, Bhashyam AR, Cervo M, Kitada T, Glass K, Owen CA, Mahmood A, Washko GR, Hashimoto S, Ryter SW, Choi AM. Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD. J Clin Invest. 2014 Sep; 124(9):3987-4003. PMID: 25083992.
    Citations: 83     Fields:    Translation:AnimalsCells
  47. Roychaudhuri R, Hergrueter AH, Polverino F, Laucho-Contreras ME, Gupta K, Borregaard N, Owen CA. ADAM9 is a novel product of polymorphonuclear neutrophils: regulation of expression and contributions to extracellular matrix protein degradation during acute lung injury. J Immunol. 2014 Sep 01; 193(5):2469-82. PMID: 25063875.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  48. Matteis M, Polverino F, Spaziano G, Roviezzo F, Santoriello C, Sullo N, Bucci MR, Rossi F, Polverino M, Owen CA, D'Agostino B. Effects of sex hormones on bronchial reactivity during the menstrual cycle. BMC Pulm Med. 2014 Jul 01; 14:108. PMID: 24984749.
    Citations: 4     Fields:    Translation:Humans
  49. Cicchitto G, Musella V, Acitorio M, Capuano N, Fiorenzano G, Owen CA, Polverino M, Polverino F. Idiopathic pulmonary fibrosis and coronary artery disease. Multidiscip Respir Med. 2014; 9(1):31. PMID: 24976970.
    Citations: 1     
  50. Craig VJ, Polverino F, Laucho-Contreras ME, Shi Y, Liu Y, Osorio JC, Tesfaigzi Y, Pinto-Plata V, Gochuico BR, Rosas IO, Owen CA. Mononuclear phagocytes and airway epithelial cells: novel sources of matrix metalloproteinase-8 (MMP-8) in patients with idiopathic pulmonary fibrosis. PLoS One. 2014; 9(5):e97485. PMID: 24828408.
    Citations: 8     Fields:    Translation:HumansCells
  51. Petersen H, Sood A, Meek PM, Shen X, Cheng Y, Belinsky SA, Owen CA, Washko G, Pinto-Plata V, Kelly E, Celli B, Tesfaigzi Y. Rapid lung function decline in smokers is a risk factor for COPD and is attenuated by angiotensin-converting enzyme inhibitor use. Chest. 2014 Apr; 145(4):695-703. PMID: 24008986.
    Citations: 14     Fields:    Translation:Humans
  52. Celli BR, Owen CA. The club cell and its protein, CC16: time to shine. Lancet Respir Med. 2013 Dec; 1(10):757-9. PMID: 24461745.
    Citations: 2     Fields:    Translation:HumansPHPublic Health
  53. Lam HC, Cloonan SM, Bhashyam AR, Haspel JA, Singh A, Sathirapongsasuti JF, Cervo M, Yao H, Chung AL, Mizumura K, An CH, Shan B, Franks JM, Haley KJ, Owen CA, Tesfaigzi Y, Washko GR, Quackenbush J, Silverman EK, Rahman I, Kim HP, Mahmood A, Biswal SS, Ryter SW, Choi AM. Histone deacetylase 6-mediated selective autophagy regulates COPD-associated cilia dysfunction. J Clin Invest. 2013 Dec; 123(12):5212-30. PMID: 24200693.
    Citations: 68     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  54. Knolle MD, Nakajima T, Hergrueter A, Gupta K, Polverino F, Craig VJ, Fyfe SE, Zahid M, Permaul P, Cernadas M, Montano G, Tesfaigzi Y, Sholl L, Kobzik L, Israel E, Owen CA. Adam8 limits the development of allergic airway inflammation in mice. J Immunol. 2013 Jun 15; 190(12):6434-49. PMID: 23670189.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  55. Kelly E, Owen CA, Abraham A, Knowlton DL, Celli BR, Pinto-Plata V. Comparison of arterial and venous blood biomarker levels in chronic obstructive pulmonary disease. F1000Res. 2013; 2:114. PMID: 24555057.
    Citations: 1     
  56. Craig VJ, Quintero PA, Fyfe SE, Patel AS, Knolle MD, Kobzik L, Owen CA. Profibrotic activities for matrix metalloproteinase-8 during bleomycin-mediated lung injury. J Immunol. 2013 Apr 15; 190(8):4283-96. PMID: 23487425.
    Citations: 16     Fields:    Translation:HumansAnimals
  57. Gupta K, Hergrueter A, Owen CA. Adipose-derived stem cells weigh in as novel therapeutics for acute lung injury. Stem Cell Res Ther. 2013 Feb 28; 4(1):19. PMID: 23510703.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  58. Kelly E, Owen CA, Pinto-Plata V, Celli BR. The role of systemic inflammatory biomarkers to predict mortality in chronic obstructive pulmonary disease. Expert Rev Respir Med. 2013 Feb; 7(1):57-64. PMID: 23362815.
    Citations: 6     Fields:    Translation:Humans
  59. Moghadaszadeh B, Rider BE, Lawlor MW, Childers MK, Grange RW, Gupta K, Boukedes SS, Owen CA, Beggs AH. Selenoprotein N deficiency in mice is associated with abnormal lung development. FASEB J. 2013 Apr; 27(4):1585-99. PMID: 23325319.
    Citations: 10     Fields:    Translation:HumansAnimals
  60. Sethi S, Mahler DA, Marcus P, Owen CA, Yawn B, Rennard S. Inflammation in COPD: implications for management. Am J Med. 2012 Dec; 125(12):1162-70. PMID: 23164484.
    Citations: 22     Fields:    Translation:HumansCells
  61. Nakajima T, Owen CA. Interleukin-18: the master regulator driving destructive and remodeling processes in the lungs of patients with chronic obstructive pulmonary disease? Am J Respir Crit Care Med. 2012 Jun 01; 185(11):1137-9. PMID: 22661518.
    Citations: 3     Fields:    Translation:Animals
  62. Baron RM, Choi AJ, Owen CA, Choi AM. Genetically manipulated mouse models of lung disease: potential and pitfalls. Am J Physiol Lung Cell Mol Physiol. 2012 Mar 15; 302(6):L485-97. PMID: 22198907.
    Citations: 16     Fields:    Translation:HumansAnimals
  63. Nakajima T, Owen CA. Polymorphonuclear neutrophils move into the fast lane in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2011 May 01; 183(9):1118-20. PMID: 21531949.
    Citations:    Fields:    Translation:HumansCells
  64. Hergrueter AH, Nguyen K, Owen CA. Matrix metalloproteinases: all the RAGE in the acute respiratory distress syndrome. Am J Physiol Lung Cell Mol Physiol. 2011 Apr; 300(4):L512-5. PMID: 21296893.
    Citations: 10     Fields:    Translation:HumansAnimals
  65. Quintero PA, Knolle MD, Cala LF, Zhuang Y, Owen CA. Matrix metalloproteinase-8 inactivates macrophage inflammatory protein-1 alpha to reduce acute lung inflammation and injury in mice. J Immunol. 2010 Feb 01; 184(3):1575-88. PMID: 20042585.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  66. Knolle MD, Owen CA. ADAM8: a new therapeutic target for asthma. Expert Opin Ther Targets. 2009 May; 13(5):523-40. PMID: 19397475.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  67. Takamiya R, Hung CC, Hall SR, Fukunaga K, Nagaishi T, Maeno T, Owen C, Macias AA, Fredenburgh LE, Ishizaka A, Blumberg RS, Baron RM, Perrella MA. High-mobility group box 1 contributes to lethality of endotoxemia in heme oxygenase-1-deficient mice. Am J Respir Cell Mol Biol. 2009 Aug; 41(2):129-35. PMID: 19097991.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  68. Owen CA. Leukocyte cell surface proteinases: regulation of expression, functions, and mechanisms of surface localization. Int J Biochem Cell Biol. 2008; 40(6-7):1246-72. PMID: 18329945.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  69. Owen CA. Roles for proteinases in the pathogenesis of chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2008; 3(2):253-68. PMID: 18686734.
    Citations: 44     Fields:    Translation:HumansAnimals
  70. Maeno T, Houghton AM, Quintero PA, Grumelli S, Owen CA, Shapiro SD. CD8+ T Cells are required for inflammation and destruction in cigarette smoke-induced emphysema in mice. J Immunol. 2007 Jun 15; 178(12):8090-6. PMID: 17548647.
    Citations: 85     Fields:    Translation:AnimalsCells
  71. Campbell EJ, Owen CA. The sulfate groups of chondroitin sulfate- and heparan sulfate-containing proteoglycans in neutrophil plasma membranes are novel binding sites for human leukocyte elastase and cathepsin G. J Biol Chem. 2007 May 11; 282(19):14645-54. PMID: 17384412.
    Citations: 25     Fields:    Translation:HumansCells
  72. Chu EK, Cheng J, Foley JS, Mecham BH, Owen CA, Haley KJ, Mariani TJ, Kohane IS, Tschumperlin DJ, Drazen JM. Induction of the plasminogen activator system by mechanical stimulation of human bronchial epithelial cells. Am J Respir Cell Mol Biol. 2006 Dec; 35(6):628-38. PMID: 16794260.
    Citations: 22     Fields:    Translation:HumansCells
  73. Owen CA. Proteinases as targets in the treatment of COPD. In. The Science of COPD: Opportunities for Combination Therapy. eds. S. Rennard. 2006; 33-34.
  74. Owen CA. Serine Proteinases: Overview. In. Encyclopedia of Respiratory Medicine. eds GJ Laurent and SD Shapiro. 2006; 4:1-9.
  75. Owen CA. Clinical Assessment of proteinase and oxidants in the treatment of COPD. In. Proceedings of the American Thoracic Society. 2005; 2(4):373-385.
  76. Owen CA. Proteinases and oxidants as targets in the treatment of chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2005; 2(4):373-85; discussion 394-5. PMID: 16267366.
    Citations: 25     Fields:    Translation:HumansAnimals
  77. Dahl M, Blobel CP, Owen CA. ADAM15 inhibits macrophage and lymphocyte accumulation in the lungs of cigarette smoke exposed mice. Proc Am Thoracic Soc. 2005; 2:A137.
  78. Zhuang Y, Owen CA. PMN express a membrane-bound form of TIMP-1: Counterintuitive roles in anchoring and promoting the pericellular activity of MP-8 and MMP-9. Proc Am Thoracic Soc. 2005; 2:A481.
  79. Roychaudhuri R, Blobel CP, Owen CA. ADAM 9 is a matrix degrading inflammatory cell proteinase but is not required for PMN migration into the lung during acute lung injury in mice. Proc Am Thoracic Soc. 2005; 2:A838.
  80. Owen CA, Zhuang Y, Quintero P, Lopez-Otin C, Shapiro SD. MMP-8 has a novel anti-inflammatory role in acute lung injury. Proc Am Thoracic Soc. 2005; 2:A148.
  81. Owen CA, Hu Z, Lopez-Otin C, Shapiro SD. Membrane-bound matrix metalloproteinase-8 on activated polymorphonuclear cells is a potent, tissue inhibitor of metalloproteinase-resistant collagenase and serpinase. J Immunol. 2004 Jun 15; 172(12):7791-803. PMID: 15187163.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  82. Quintero PA, Dawkins PA, Owen CA, Riese R, Shapiro SD. Total Lung Digestion: A method to study the total inflammatory response in the lung. Am J Respir Crit Care Med. 2004; 169:A813.
  83. Kaynar M, Roychaudhuri R, Shapiro SD, Owen CA. Inducible Expression of Inflammatory Cell ADAMs -8, -10, -15 and -17 During Acute Lung Injury. Am J Respir Crit Care Med. 2004; 169:A813.
  84. Roychaudhuri R, Kaynar M, Shapiro SD, Owen, CA. Human ADAM 9 and ADAM 10 can degrade lung basement membrane proteins. Am J Respir Crit Care Med. 2004; 169:A855.
  85. Anthwal S, Xu J, Opdenakker G, Soloway PD, Shapiro SD, Owen CA. Membrane-bound TIMP-1 on PMN has a Counter Intuitive Role in Anchoring MMP-9 to the Cell Surface and Promoting Cell Associated MMP. Am J Respir Crit Care Med. 2004; 169:A867.
  86. Dollery CM, Owen CA, Sukhova GK, Krettek A, Shapiro SD, Libby P. Neutrophil elastase in human atherosclerotic plaques: production by macrophages. Circulation. 2003 Jun 10; 107(22):2829-36. PMID: 12771009.
    Citations: 48     Fields:    Translation:HumansCells
  87. Owen CA, Hu Z, Barrick B, Shapiro SD. Inducible expression of tissue inhibitor of metalloproteinases-resistant matrix metalloproteinase-9 on the cell surface of neutrophils. Am J Respir Cell Mol Biol. 2003 Sep; 29(3 Pt 1):283-94. PMID: 12663332.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  88. Owen CA, Otin-Lopez C, Shapiro SD. Novel, anti-inflammatory roles for matrix metalloproteinase-8 in acute lung injury. Am J Respir Crit Care Med. 2003; 167:A195.
  89. Dunsmore SE, Rzymkiewiez DM, Owen CA, Roes J, Laurant GJ, Shapiro SD. Cathepsin G induces alveolar epithelial cell apoptosis: potential role in alveolar repair. Am J Respir Crit Care Med. 2003; 167:A649.
  90. Kaynar M, Owen CA, Shapiro SD. Dihydro-ß-erythroidine - an a4ß2 nACh-receptor antagonist abolishes the protective effects of nicotine on LPS-stimulated macrophages. Am Soc Anasthesiol. 2003.
  91. Anthwal S, Opdenakker G, Soloway PD, Shapiro, SD, Owen CA. TIMP-1 Promotes pericellular proteolysis by anchoring active MMP-9 to PMN cell surface. J Leukocyte Biol. 2003; 23(suppl):A35.
  92. Owen CA, Wang W, Shapiro SD. Up-regulation of the expression of ADAMs on inflammatory cells during acute lung injury. Am J Respir Crit Care Med. 2003; 167:A195.
  93. Shapiro SD, Owen CA. ADAM-33 surfaces as an asthma gene. N Engl J Med. 2002 Sep 19; 347(12):936-8. PMID: 12239266.
    Citations: 12     Fields:    Translation:HumansAnimals
  94. Campbell EJ, Campbell MA, Owen CA. Bioactive proteinase 3 on the cell surface of human neutrophils: quantification, catalytic activity, and susceptibility to inhibition. J Immunol. 2000 Sep 15; 165(6):3366-74. PMID: 10975855.
    Citations: 44     Fields:    Translation:HumansCells
  95. Campbell EJ, Campbell MA, Boukedes SS, Owen CA. Quantum proteolysis by neutrophils : implications for pulmonary emphysema in alpha(1)-antitrypsin deficiency Chest. 2000 May; 117(5 Suppl 1):303S. PMID: 10843966.
    Citations: 1     Fields:    
  96. Campbell EJ, Campbell MA, Boukedes SS, Owen CA. Quantum proteolysis by neutrophils in alpha 1 anti-trypsin deficiency. Chest. 2000; 117:303S.
  97. Owen CA. Pericellular proteolysis by inflammatory cells: Interactions between cytokines, chemokines, and proteinases on the cell surface. The Weizman Institute of Science and The Center for the Study of Emerging Diseases. 2000; 1:A17.
  98. Barrick B, Campbell EJ, Owen CA. Leukocyte proteinases in wound healing: roles in physiologic and pathologic processes. Wound Repair Regen. 1999 Nov-Dec; 7(6):410-22. PMID: 10633000.
    Citations: 15     Fields:    Translation:HumansCells
  99. Owen CA, Campbell EJ. Extracellular proteolysis: new paradigms for an old paradox. J Lab Clin Med. 1999 Oct; 134(4):341-51. PMID: 10521080.
    Citations: 5     Fields:    Translation:HumansCells
  100. Campbell EJ, Campbell MA, Boukedes SS, Owen CA. Quantum proteolysis by neutrophils: implications for pulmonary emphysema in alpha 1-antitrypsin deficiency. J Clin Invest. 1999 Aug; 104(3):337-44. PMID: 10430615.
    Citations: 16     Fields:    Translation:HumansCells
  101. Morrison HM, Welgus HG, Owen CA, Stockley RA, Campbell EJ. Interaction between leukocyte elastase and elastin: quantitative and catalytic analyses. Biochim Biophys Acta. 1999 Mar 19; 1430(2):179-90. PMID: 10082946.
    Citations: 5     Fields:    Translation:HumansCells
  102. Owen CA, Campbell EJ. The cell biology of leukocyte-mediated proteolysis. J Leukoc Biol. 1999 Feb; 65(2):137-50. PMID: 10088596.
    Citations: 87     Fields:    Translation:HumansCells
  103. Owen CA, Campbell EJ. Angiotensin II generation at the cell surface of activated neutrophils: novel cathepsin G-mediated catalytic activity that is resistant to inhibition. J Immunol. 1998 Feb 01; 160(3):1436-43. PMID: 9570564.
    Citations: 22     Fields:    Translation:HumansCells
  104. Owen CA, Campbell MA, Boukedes SS, Campbell EJ. Cytokines regulate membrane-bound leukocyte elastase on neutrophils: a novel mechanism for effector activity. Am J Physiol. 1997 Mar; 272(3 Pt 1):L385-93. PMID: 9124593.
    Citations: 17     Fields:    Translation:HumansCells
  105. Owen CA, Campbell EJ. Proteinases in the adult respiratory distress syndrom. In. Adult Respiratory Distress Syndrom. eds. C Haslett, T Evans. 1996; 139-165.
  106. Owen CA, Campbell MA, Boukedes SS, Campbell EJ. Inducible binding of bioactive cathepsin G to the cell surface of neutrophils. A novel mechanism for mediating extracellular catalytic activity of cathepsin G. J Immunol. 1995 Dec 15; 155(12):5803-10. PMID: 7499869.
    Citations: 22     Fields:    Translation:HumansCells
  107. Owen CA, Campbell EJ. Neutrophil proteinases and matrix degradation. The cell biology of pericellular proteolysis. Semin Cell Biol. 1995 Dec; 6(6):367-76. PMID: 8748144.
    Citations: 10     Fields:    Translation:HumansCells
  108. Owen CA, Campbell MA, Sannes PL, Boukedes SS, Campbell EJ. Cell surface-bound elastase and cathepsin G on human neutrophils: a novel, non-oxidative mechanism by which neutrophils focus and preserve catalytic activity of serine proteinases. J Cell Biol. 1995 Nov; 131(3):775-89. PMID: 7593196.
    Citations: 72     Fields:    Translation:HumansCells
  109. Owen CA, Campbell MA, Boukedes SS, Campbell EJ. Monocytes recruited to sites of inflammation express a distinctive proinflammatory (P) phenotype. Am J Physiol. 1994 Dec; 267(6 Pt 1):L786-96. PMID: 7810683.
    Citations: 6     Fields:    Translation:HumansCells
  110. Owen CA, Campbell MA, Boukedes SS, Stockley RA, Campbell EJ. A discrete subpopulation of human monocytes expresses a neutrophil-like proinflammatory (P) phenotype. Am J Physiol. 1994 Dec; 267(6 Pt 1):L775-85. PMID: 7810682.
    Citations: 18     Fields:    Translation:HumansCells
  111. Owen CA. Functional heterogenity of human monocytes: monocyte adherence to fibronectin and its relationship to other monocyte functions. 1993.
  112. Owen CA. Recent advances in somatic gene therapy for hereditary respiratory diseases. Thorax. 1992 Apr; 47(4):315-6. PMID: 1585298.
    Citations:    Fields:    Translation:Humans
  113. Owen CA, Campbell EJ, Stockley RA. Monocyte adherence to fibronectin: role of CD11/CD18 integrins and relationship to other monocyte functions. J Leukoc Biol. 1992 Apr; 51(4):400-8. PMID: 1348780.
    Citations: 10     Fields:    Translation:HumansCells
  114. Owen CA, Campbell EJ, Hill SL, Stockley RA. Increased adherence of monocytes to fibronectin in bronchiectasis. Regulatory effects of bacterial lipopolysaccharide and role of CD11/CD18 integrins. Am Rev Respir Dis. 1992 Mar; 145(3):626-31. PMID: 1546844.
    Citations: 5     Fields:    Translation:HumansCells
  115. Owen CA, Stockley RA. Molecular biology and respiratory disease. 2-- Applications to the study and treatment of respiratory disease: methods in molecular biology. Thorax. 1990 Feb; 45(2):147-53. PMID: 2180109.
    Citations:    Fields:    Translation:HumansCells
  116. Owen CA, Stockley RA. Molecular biology and respiratory disease. I-- Basic principles. Thorax. 1990 Jan; 45(1):52-6. PMID: 2181718.
    Citations:    Fields:    Translation:HumansCells
  117. Williams AC, Owen CA, Heath D. A compulsive movement disorder with cavitation of the caudate nucleus. J Neurol Neurosurg Psych. 1988; 51:447-448.
  118. Divertie MB, Owen CA, Barham SS, Ludwig J. Accumulation of radionuclide-labeled platelets and fibrinogen in paraquat-damaged rat lungs. Am Rev Respir Dis. 1982 Oct; 126(4):740. PMID: 7125373.
    Citations:    Fields:    Translation:Animals
  119. Su LC, Ravanshad S, Owen CA, McCall JT, Zollman PE, Hardy RM. A comparison of copper-loading disease in Bedlington terriers and Wilson's disease in humans. Am J Physiol. 1982 Sep; 243(3):G226-30. PMID: 7114265.
    Citations: 17     Fields:    Translation:HumansAnimals
  120. Divertie MB, Owen CA, Barham SS, Ludwig J. Accumulation of radionuclide-labeled platelets and fibrinogen in paraquat-damaged rat lungs. Am Rev Respir Dis. 1982 May; 125(5):574-8. PMID: 7081818.
    Citations: 2     Fields:    Translation:AnimalsCells
  121. Owen CA, Ludwig J. Inherited copper toxicosis in Bedlington terriers: Wilson's disease (hepatolenticular degeneration). Am J Pathol. 1982 Mar; 106(3):432-4. PMID: 7065120.
    Citations: 6     Fields:    Translation:HumansAnimals
  122. Sun NC, Bowie EJ, Titus JL, Owen CA. Effect of induced chronic intravascular coagulation on plasminogen activator in dogs. Thromb Diath Haemorrh. 1974 Sep 30; 32(1):189-202. PMID: 4454038.
    Citations: 2     Fields:    Translation:AnimalsCells
  123. Bowie EJ, Owen CA. Aspirin, platelets, and bleeding. Circulation. 1969 Dec; 40(6):757-60. PMID: 5387355.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  124. Wollenweber J, Kottke BA, Owen CA. Pool size and turnover of bile acids in six hypercholesteremic patients with and without administration of nicotinic acid. J Lab Clin Med. 1967 Apr; 69(4):584-93. PMID: 6020697.
    Citations: 5     Fields:    Translation:Humans
  125. Harrison CE, Brandenburg RO, Ongley PA, Orvis AL, Owen CA. The distribution and excretion of tritiated substances in experimental animals following the administration of digoxin-3H. J Lab Clin Med. 1966 May; 67(5):764-77. PMID: 5946035.
    Citations: 13     Fields:    Translation:Animals
  126. Rodriguez Garay EA, Owen CA, Flock EV. Formation of bilirubin in normal, damaged, and Gunn rat livers. J Lab Clin Med. 1966 May; 67(5):817-29. PMID: 5946037.
    Citations:    Fields:    Translation:Animals
  127. Bowie EJ, Todd M, Thompson JH, Owen CA, Wright IS. Anticoagulant malingerers (the "dicumarol-eaters"). Am J Med. 1965 Nov; 39(5):855-64. PMID: 4158003.
    Citations: 3     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.