Harvard Catalyst Profiles

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Sylvie Le Gall, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21AI143449 (LE GALL, SYLVIE) Feb 15, 2019 - Dec 31, 2019
    Identification of novel HIV-derived antigens
    Role: Principal Investigator
  2. R21AI129717 (LE GALL, SYLVIE) Jul 14, 2017 - Dec 31, 2019
    The HLA-E peptidome in HIV infection
    Role: Principal Investigator
  3. R21AI131912 (LE GALL, SYLVIE) Jun 26, 2017 - Dec 31, 2019
    Unbiased identification of HIV-derived antigens during latency and reactivation
    Role: Principal Investigator
  4. R56AI122947 (LE GALL, SYLVIE) Aug 15, 2016 - Jul 31, 2018
    Defining and matching epitope presentation in HIV infection and vaccination
    Role: Principal Investigator
  5. R01AI123286 (BEHAR, SAMUEL M) Feb 15, 2016 - Jan 31, 2021
    Tuberculosis and T cell Recognition
    Role: Co-Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Sutiwisesak R, Hicks ND, Boyce S, Murphy KC, Papavinasasundaram K, Carpenter SM, Boucau J, Joshi N, Le Gall S, Fortune SM, Sassetti CM, Behar SM. A natural polymorphism of Mycobacterium tuberculosis in the esxH gene disrupts immunodomination by the TB10.4-specific CD8 T cell response. PLoS Pathog. 2020 10; 16(10):e1009000. PMID: 33075106.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  2. Boucau J, Das J, Joshi N, Le Gall S. Latency reversal agents modulate HIV antigen processing and presentation to CD8 T cells. PLoS Pathog. 2020 03; 16(3):e1008442. PMID: 32196533.
    Citations: 2     Fields:    Translation:HumansCells
  3. Kulkarni S, Lied A, Kulkarni V, Rucevic M, Martin MP, Walker-Sperling V, Anderson SK, Ewy R, Singh S, Nguyen H, McLaren PJ, Viard M, Naranbhai V, Zou C, Lin Z, Gatanaga H, Oka S, Takiguchi M, Thio CL, Margolick J, Kirk GD, Goedert JJ, Hoots WK, Deeks SG, Haas DW, Michael N, Walker B, Le Gall S, Chowdhury FZ, Yu XG, Carrington M. Author Correction: CCR5AS lncRNA variation differentially regulates CCR5, influencing HIV disease outcome. Nat Immunol. 2019 Nov; 20(11):1555. PMID: 31548709.
    Citations:    Fields:    
  4. Kulkarni S, Lied A, Kulkarni V, Rucevic M, Martin MP, Walker-Sperling V, Anderson SK, Ewy R, Singh S, Nguyen H, McLaren PJ, Viard M, Naranbhai V, Zou C, Lin Z, Gatanaga H, Oka S, Takiguchi M, Thio CL, Margolick J, Kirk GD, Goedert JJ, Hoots WK, Deeks SG, Haas DW, Michael N, Walker B, Le Gall S, Chowdhury FZ, Yu XG, Carrington M. CCR5AS lncRNA variation differentially regulates CCR5, influencing HIV disease outcome. Nat Immunol. 2019 07; 20(7):824-834. PMID: 31209403.
    Citations: 19     Fields:    Translation:HumansCells
  5. Monel B, McKeon A, Lamothe-Molina P, Jani P, Boucau J, Pacheco Y, Jones RB, Le Gall S, Walker BD. HIV Controllers Exhibit Effective CD8+ T Cell Recognition of HIV-1-Infected Non-activated CD4+ T Cells. Cell Rep. 2019 04 02; 27(1):142-153.e4. PMID: 30943397.
    Citations: 5     Fields:    Translation:HumansCells
  6. Boucau J, Madouasse J, Kourjian G, Carlin CS, Wambua D, Berberich MJ, Le Gall S. The Activation State of CD4 T Cells Alters Cellular Peptidase Activities, HIV Antigen Processing, and MHC Class I Presentation in a Sequence-Dependent Manner. J Immunol. 2019 05 15; 202(10):2856-2872. PMID: 30936293.
    Citations: 3     Fields:    Translation:HumansCellsCTClinical Trials
  7. Moynihan KD, Holden RL, Mehta NK, Wang C, Karver MR, Dinter J, Liang S, Abraham W, Melo MB, Zhang AQ, Li N, Gall SL, Pentelute BL, Irvine DJ. Enhancement of Peptide Vaccine Immunogenicity by Increasing Lymphatic Drainage and Boosting Serum Stability. Cancer Immunol Res. 2018 09; 6(9):1025-1038. PMID: 29915023.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  8. Boucau J, Le Gall S. Antigen processing and presentation in HIV infection. Mol Immunol. 2019 09; 113:67-74. PMID: 29636181.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  9. Kulkarni S, Ramsuran V, Rucevic M, Singh S, Lied A, Kulkarni V, O'hUigin C, Le Gall S, Carrington M. Posttranscriptional Regulation of HLA-A Protein Expression by Alternative Polyadenylation Signals Involving the RNA-Binding Protein Syncrip. J Immunol. 2017 12 01; 199(11):3892-3899. PMID: 29055006.
    Citations: 9     Fields:    Translation:HumansCells
  10. Rucevic M, Kourjian G, Boucau J, Blatnik R, Garcia Bertran W, Berberich MJ, Walker BD, Riemer AB, Le Gall S. Analysis of Major Histocompatibility Complex-Bound HIV Peptides Identified from Various Cell Types Reveals Common Nested Peptides and Novel T Cell Responses. J Virol. 2016 10 01; 90(19):8605-20. PMID: 27440904.
    Citations: 7     Fields:    Translation:HumansCells
  11. Kourjian G, Rucevic M, Berberich MJ, Dinter J, Wambua D, Boucau J, Le Gall S. HIV Protease Inhibitor-Induced Cathepsin Modulation Alters Antigen Processing and Cross-Presentation. J Immunol. 2016 05 01; 196(9):3595-607. PMID: 27009491.
    Citations: 9     Fields:    Translation:HumansCells
  12. Davis ZB, Cogswell A, Scott H, Mertsching A, Boucau J, Wambua D, Le Gall S, Planelles V, Campbell KS, Barker E. A Conserved HIV-1-Derived Peptide Presented by HLA-E Renders Infected T-cells Highly Susceptible to Attack by NKG2A/CD94-Bearing Natural Killer Cells. PLoS Pathog. 2016 Feb; 12(2):e1005421. PMID: 26828202.
    Citations: 38     Fields:    Translation:HumansCells
  13. Griesbeck M, Ziegler S, Laffont S, Smith N, Chauveau L, Tomezsko P, Sharei A, Kourjian G, Porichis F, Hart M, Palmer CD, Sirignano M, Beisel C, Hildebrandt H, Cénac C, Villani AC, Diefenbach TJ, Le Gall S, Schwartz O, Herbeuval JP, Autran B, Guéry JC, Chang JJ, Altfeld M. Sex Differences in Plasmacytoid Dendritic Cell Levels of IRF5 Drive Higher IFN-a Production in Women. J Immunol. 2015 Dec 01; 195(11):5327-36. PMID: 26519527.
    Citations: 55     Fields:    Translation:HumansAnimalsCells
  14. Dinter J, Duong E, Lai NY, Berberich MJ, Kourjian G, Bracho-Sanchez E, Chu D, Su H, Zhang SC, Le Gall S. Variable processing and cross-presentation of HIV by dendritic cells and macrophages shapes CTL immunodominance and immune escape. PLoS Pathog. 2015 Mar; 11(3):e1004725. PMID: 25781895.
    Citations: 18     Fields:    Translation:HumansCells
  15. Mattison CP, Dinter J, Berberich MJ, Chung SY, Reed SS, Le Gall S, Grimm CC. In vitro evaluation of digestive and endolysosomal enzymes to cleave CML-modified Ara h 1 peptides. Food Sci Nutr. 2015 Jul; 3(4):273-83. PMID: 26288719.
    Citations: 2     
  16. Kourjian G, Poplimont H, Mondesire-Crump I, Berberich M, Su H, Le Gall S. HAART alters multiple cellular peptidase activities and predictably modifies protein degradation patterns, epitope production and presentation. AIDS Res Hum Retroviruses. 2014 Oct; 30 Suppl 1:A181. PMID: 25357509.
  17. Felber BK, Hu X, Kulkarni V, Valentin A, Rosati M, Alicea C, Rolland M, Le Gall S, Sardesai NY, Mothe B, Brander C, Mullins JI, Pavlakis GN. Expanded Epitope Recognition by Vaccination with DNA Encoding Novel Immunogens Comprising HIV Conserved Elements. AIDS Res Hum Retroviruses. 2014 Oct; 30 Suppl 1:A45-6. PMID: 25357859.
  18. Dinter J, Gourdain P, Lai NY, Duong E, Bracho-Sanchez E, Rucevic M, Liebesny PH, Xu Y, Shimada M, Ghebremichael M, Kavanagh DG, Le Gall S. Different antigen-processing activities in dendritic cells, macrophages, and monocytes lead to uneven production of HIV epitopes and affect CTL recognition. J Immunol. 2014 Nov 01; 193(9):4322-4334. PMID: 25230751.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  19. Rucevic M, Boucau J, Dinter J, Kourjian G, Le Gall S. Mechanisms of HIV protein degradation into epitopes: implications for vaccine design. Viruses. 2014 Aug 21; 6(8):3271-92. PMID: 25196483.
    Citations: 4     Fields:    Translation:HumansCells
  20. Kourjian G, Xu Y, Mondesire-Crump I, Shimada M, Gourdain P, Le Gall S. Sequence-specific alterations of epitope production by HIV protease inhibitors. J Immunol. 2014 Apr 15; 192(8):3496-506. PMID: 24616479.
    Citations: 13     Fields:    Translation:HumansCells
  21. Kulkarni V, Valentin A, Rosati M, Alicea C, Singh AK, Jalah R, Broderick KE, Sardesai NY, Le Gall S, Mothe B, Brander C, Rolland M, Mullins JI, Pavlakis GN, Felber BK. Altered response hierarchy and increased T-cell breadth upon HIV-1 conserved element DNA vaccination in macaques. PLoS One. 2014; 9(1):e86254. PMID: 24465991.
    Citations: 37     Fields:    Translation:AnimalsCellsPHPublic Health
  22. Buzon MJ, Yang Y, Ouyang Z, Sun H, Seiss K, Rogich J, Le Gall S, Pereyra F, Rosenberg ES, Yu XG, Lichterfeld M. Susceptibility to CD8 T-cell-mediated killing influences the reservoir of latently HIV-1-infected CD4 T cells. . 2014 Jan 01; 65(1):1-9. PMID: 23846565.
    Citations: 12     Translation:HumansCells
  23. Gourdain P, Boucau J, Kourjian G, Lai NY, Duong E, Le Gall S. A real-time killing assay to follow viral epitope presentation to CD8 T cells. J Immunol Methods. 2013 Dec 15; 398-399:60-7. PMID: 24060536.
    Citations: 3     Fields:    Translation:HumansCellsCTClinical Trials
  24. Vaithilingam A, Lai NY, Duong E, Boucau J, Xu Y, Shimada M, Gandhi M, Le Gall S. A simple methodology to assess endolysosomal protease activity involved in antigen processing in human primary cells. BMC Cell Biol. 2013 Aug 09; 14:35. PMID: 23937268.
    Citations: 9     Fields:    Translation:HumansCells
  25. Balamurugan A, Ali A, Boucau J, Le Gall S, Ng HL, Yang OO. HIV-1 gag cytotoxic T lymphocyte epitopes vary in presentation kinetics relative to HLA class I downregulation. J Virol. 2013 Aug; 87(15):8726-34. PMID: 23740989.
    Citations: 6     Fields:    Translation:HumansCells
  26. Kulkarni V, Rosati M, Valentin A, Ganneru B, Singh AK, Yan J, Rolland M, Alicea C, Beach RK, Zhang GM, Le Gall S, Broderick KE, Sardesai NY, Heckerman D, Mothe B, Brander C, Weiner DB, Mullins JI, Pavlakis GN, Felber BK. HIV-1 p24(gag) derived conserved element DNA vaccine increases the breadth of immune response in mice. PLoS One. 2013; 8(3):e60245. PMID: 23555935.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  27. Zhang SC, Martin E, Shimada M, Godfrey SB, Fricke J, Locastro S, Lai NY, Liebesny P, Carlson JM, Brumme CJ, Ogbechie OA, Chen H, Walker BD, Brumme ZL, Kavanagh DG, Le Gall S. Aminopeptidase substrate preference affects HIV epitope presentation and predicts immune escape patterns in HIV-infected individuals. J Immunol. 2012 Jun 15; 188(12):5924-34. PMID: 22586036.
    Citations: 23     Fields:    Translation:Humans
  28. Lazaro E, Kadie C, Stamegna P, Zhang SC, Gourdain P, Lai NY, Zhang M, Martinez SA, Heckerman D, Le Gall S. Variable HIV peptide stability in human cytosol is critical to epitope presentation and immune escape. J Clin Invest. 2011 Jun; 121(6):2480-92. PMID: 21555856.
    Citations: 27     Fields:    Translation:HumansCells
  29. Kessler JH, Khan S, Seifert U, Le Gall S, Chow KM, Paschen A, Bres-Vloemans SA, de Ru A, van Montfoort N, Franken KL, Benckhuijsen WE, Brooks JM, van Hall T, Ray K, Mulder A, Doxiadis II, van Swieten PF, Overkleeft HS, Prat A, Tomkinson B, Neefjes J, Kloetzel PM, Rodgers DW, Hersh LB, Drijfhout JW, van Veelen PA, Ossendorp F, Melief CJ. Antigen processing by nardilysin and thimet oligopeptidase generates cytotoxic T cell epitopes. Nat Immunol. 2011 Jan; 12(1):45-53. PMID: 21151101.
    Citations: 47     Fields:    Translation:HumansCells
  30. Pereyra F, Jia X, McLaren PJ, Telenti A, de Bakker PI, Walker BD, Ripke S, Brumme CJ, Pulit SL, Carrington M, Kadie CM, Carlson JM, Heckerman D, Graham RR, Plenge RM, Deeks SG, Gianniny L, Crawford G, Sullivan J, Gonzalez E, Davies L, Camargo A, Moore JM, Beattie N, Gupta S, Crenshaw A, Burtt NP, Guiducci C, Gupta N, Gao X, Qi Y, Yuki Y, Piechocka-Trocha A, Cutrell E, Rosenberg R, Moss KL, Lemay P, O'Leary J, Schaefer T, Verma P, Toth I, Block B, Baker B, Rothchild A, Lian J, Proudfoot J, Alvino DM, Vine S, Addo MM, Allen TM, Altfeld M, Henn MR, Le Gall S, Streeck H, Haas DW, Kuritzkes DR, Robbins GK, Shafer RW, Gulick RM, Shikuma CM, Haubrich R, Riddler S, Sax PE, Daar ES, Ribaudo HJ, Agan B, Agarwal S, Ahern RL, Allen BL, Altidor S, Altschuler EL, Ambardar S, Anastos K, Anderson B, Anderson V, Andrady U, Antoniskis D, Bangsberg D, Barbaro D, Barrie W, Bartczak J, Barton S, Basden P, Basgoz N, Bazner S, Bellos NC, Benson AM, Berger J, Bernard NF, Bernard AM, Birch C, Bodner SJ, Bolan RK, Boudreaux ET, Bradley M, Braun JF, Brndjar JE, Brown SJ, Brown K, Brown ST, Burack J, Bush LM, Cafaro V, Campbell O, Campbell J, Carlson RH, Carmichael JK, Casey KK, Cavacuiti C, Celestin G, Chambers ST, Chez N, Chirch LM, Cimoch PJ, Cohen D, Cohn LE, Conway B, Cooper DA, Cornelson B, Cox DT, Cristofano MV, Cuchural G, Czartoski JL, Dahman JM, Daly JS, Davis BT, Davis K, Davod SM, DeJesus E, Dietz CA, Dunham E, Dunn ME, Ellerin TB, Eron JJ, Fangman JJ, Farel CE, Ferlazzo H, Fidler S, Fleenor-Ford A, Frankel R, Freedberg KA, French NK, Fuchs JD, Fuller JD, Gaberman J, Gallant JE, Gandhi RT, Garcia E, Garmon D, Gathe JC, Gaultier CR, Gebre W, Gilman FD, Gilson I, Goepfert PA, Gottlieb MS, Goulston C, Groger RK, Gurley TD, Haber S, Hardwicke R, Hardy WD, Harrigan PR, Hawkins TN, Heath S, Hecht FM, Henry WK, Hladek M, Hoffman RP, Horton JM, Hsu RK, Huhn GD, Hunt P, Hupert MJ, Illeman ML, Jaeger H, Jellinger RM, John M, Johnson JA, Johnson KL, Johnson H, Johnson K, Joly J, Jordan WC, Kauffman CA, Khanlou H, Killian RK, Kim AY, Kim DD, Kinder CA, Kirchner JT, Kogelman L, Kojic EM, Korthuis PT, Kurisu W, Kwon DS, LaMar M, Lampiris H, Lanzafame M, Lederman MM, Lee DM, Lee JM, Lee MJ, Lee ET, Lemoine J, Levy JA, Llibre JM, Liguori MA, Little SJ, Liu AY, Lopez AJ, Loutfy MR, Loy D, Mohammed DY, Man A, Mansour MK, Marconi VC, Markowitz M, Marques R, Martin JN, Martin HL, Mayer KH, McElrath MJ, McGhee TA, McGovern BH, McGowan K, McIntyre D, Mcleod GX, Menezes P, Mesa G, Metroka CE, Meyer-Olson D, Miller AO, Montgomery K, Mounzer KC, Nagami EH, Nagin I, Nahass RG, Nelson MO, et al. The major genetic determinants of HIV-1 control affect HLA class I peptide presentation. Science. 2010 Dec 10; 330(6010):1551-7. PMID: 21051598.
    Citations: 583     Fields:    Translation:HumansCells
  31. Hassemer EL, Le Gall SM, Liegel R, McNally M, Chang B, Zeiss CJ, Dubielzig RD, Horiuchi K, Kimura T, Okada Y, Blobel CP, Sidjanin DJ. The waved with open eyelids (woe) locus is a hypomorphic mouse mutation in Adam17. Genetics. 2010 May; 185(1):245-55. PMID: 20194968.
    Citations: 23     Fields:    Translation:AnimalsCells
  32. Lazaro E, Godfrey SB, Stamegna P, Ogbechie T, Kerrigan C, Zhang M, Walker BD, Le Gall S. Differential HIV epitope processing in monocytes and CD4 T cells affects cytotoxic T lymphocyte recognition. J Infect Dis. 2009 Jul 15; 200(2):236-43. PMID: 19505257.
    Citations: 20     Fields:    Translation:HumansCells
  33. Brockman MA, Kwon DS, Tighe DP, Pavlik DF, Rosato PC, Sela J, Porichis F, Le Gall S, Waring MT, Moss K, Jessen H, Pereyra F, Kavanagh DG, Walker BD, Kaufmann DE. IL-10 is up-regulated in multiple cell types during viremic HIV infection and reversibly inhibits virus-specific T cells. Blood. 2009 Jul 09; 114(2):346-56. PMID: 19365081.
    Citations: 129     Fields:    Translation:HumansCells
  34. Troyer RM, McNevin J, Liu Y, Zhang SC, Krizan RW, Abraha A, Tebit DM, Zhao H, Avila S, Lobritz MA, McElrath MJ, Le Gall S, Mullins JI, Arts EJ. Variable fitness impact of HIV-1 escape mutations to cytotoxic T lymphocyte (CTL) response. PLoS Pathog. 2009 Apr; 5(4):e1000365. PMID: 19343217.
    Citations: 115     Fields:    Translation:HumansCells
  35. Le Gall S, Stamegna P, Walker BD. Portable flanking sequences modulate CTL epitope processing. J Clin Invest. 2007 Nov; 117(11):3563-75. PMID: 17975674.
    Citations: 56     Fields:    Translation:HumansAnimalsCells
  36. Kaufmann DE, Kavanagh DG, Pereyra F, Zaunders JJ, Mackey EW, Miura T, Palmer S, Brockman M, Rathod A, Piechocka-Trocha A, Baker B, Zhu B, Le Gall S, Waring MT, Ahern R, Moss K, Kelleher AD, Coffin JM, Freeman GJ, Rosenberg ES, Walker BD. Upregulation of CTLA-4 by HIV-specific CD4+ T cells correlates with disease progression and defines a reversible immune dysfunction. Nat Immunol. 2007 Nov; 8(11):1246-54. PMID: 17906628.
    Citations: 258     Fields:    Translation:HumansCells
  37. Schneidewind A, Brockman MA, Yang R, Adam RI, Li B, Le Gall S, Rinaldo CR, Craggs SL, Allgaier RL, Power KA, Kuntzen T, Tung CS, LaBute MX, Mueller SM, Harrer T, McMichael AJ, Goulder PJ, Aiken C, Brander C, Kelleher AD, Allen TM. Escape from the dominant HLA-B27-restricted cytotoxic T-lymphocyte response in Gag is associated with a dramatic reduction in human immunodeficiency virus type 1 replication. J Virol. 2007 Nov; 81(22):12382-93. PMID: 17804494.
    Citations: 208     Fields:    Translation:HumansCells
  38. Kavanagh DG, Kaufmann DE, Sunderji S, Frahm N, Le Gall S, Boczkowski D, Rosenberg ES, Stone DR, Johnston MN, Wagner BS, Zaman MT, Brander C, Gilboa E, Walker BD, Bhardwaj N. Expansion of HIV-specific CD4+ and CD8+ T cells by dendritic cells transfected with mRNA encoding cytoplasm- or lysosome-targeted Nef. Blood. 2006 Mar 01; 107(5):1963-9. PMID: 16249391.
    Citations: 26     Fields:    Translation:HumansCells
  39. Leslie A, Kavanagh D, Honeyborne I, Pfafferott K, Edwards C, Pillay T, Hilton L, Thobakgale C, Ramduth D, Draenert R, Le Gall S, Luzzi G, Edwards A, Brander C, Sewell AK, Moore S, Mullins J, Moore C, Mallal S, Bhardwaj N, Yusim K, Phillips R, Klenerman P, Korber B, Kiepiela P, Walker B, Goulder P. Transmission and accumulation of CTL escape variants drive negative associations between HIV polymorphisms and HLA. J Exp Med. 2005 Mar 21; 201(6):891-902. PMID: 15781581.
    Citations: 119     Fields:    Translation:HumansCells
  40. Lichterfeld M, Yu XG, Le Gall S, Altfeld M. Immunodominance of HIV-1-specific CD8(+) T-cell responses in acute HIV-1 infection: at the crossroads of viral and host genetics. Trends Immunol. 2005 Mar; 26(3):166-71. PMID: 15745859.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  41. Allen TM, Altfeld M, Yu XG, O'Sullivan KM, Lichterfeld M, Le Gall S, John M, Mothe BR, Lee PK, Kalife ET, Cohen DE, Freedberg KA, Strick DA, Johnston MN, Sette A, Rosenberg ES, Mallal SA, Goulder PJ, Brander C, Walker BD. Selection, transmission, and reversion of an antigen-processing cytotoxic T-lymphocyte escape mutation in human immunodeficiency virus type 1 infection. J Virol. 2004 Jul; 78(13):7069-78. PMID: 15194783.
    Citations: 144     Fields:    Translation:HumansCells
  42. Draenert R, Le Gall S, Pfafferott KJ, Leslie AJ, Chetty P, Brander C, Holmes EC, Chang SC, Feeney ME, Addo MM, Ruiz L, Ramduth D, Jeena P, Altfeld M, Thomas S, Tang Y, Verrill CL, Dixon C, Prado JG, Kiepiela P, Martinez-Picado J, Walker BD, Goulder PJ. Immune selection for altered antigen processing leads to cytotoxic T lymphocyte escape in chronic HIV-1 infection. J Exp Med. 2004 Apr 05; 199(7):905-15. PMID: 15067030.
    Citations: 152     Fields:    Translation:HumansCells
  43. Le Gall S, Neuhof A, Rapoport T. The endoplasmic reticulum membrane is permeable to small molecules. Mol Biol Cell. 2004 Feb; 15(2):447-55. PMID: 14617815.
    Citations: 36     Fields:    Translation:HumansCells
  44. Stumptner-Cuvelette P, Morchoisne S, Dugast M, Le Gall S, Raposo G, Schwartz O, Benaroch P. HIV-1 Nef impairs MHC class II antigen presentation and surface expression. Proc Natl Acad Sci U S A. 2001 Oct 09; 98(21):12144-9. PMID: 11593029.
    Citations: 102     Fields:    Translation:HumansCells
  45. Janvier K, Craig H, Le Gall S, Benarous R, Guatelli J, Schwartz O, Benichou S. Nef-induced CD4 downregulation: a diacidic sequence in human immunodeficiency virus type 1 Nef does not function as a protein sorting motif through direct binding to beta-COP. J Virol. 2001 Apr; 75(8):3971-6. PMID: 11264386.
    Citations: 25     Fields:    Translation:HumansCells
  46. Buseyne F, Le Gall S, Boccaccio C, Abastado JP, Lifson JD, Arthur LO, Rivière Y, Heard JM, Schwartz O. MHC-I-restricted presentation of HIV-1 virion antigens without viral replication. Nat Med. 2001 Mar; 7(3):344-9. PMID: 11231634.
    Citations: 62     Fields:    Translation:HumansCells
  47. Le Gall S, Buseyne F, Trocha A, Walker BD, Heard JM, Schwartz O. Distinct trafficking pathways mediate Nef-induced and clathrin-dependent major histocompatibility complex class I down-regulation. J Virol. 2000 Oct; 74(19):9256-66. PMID: 10982373.
    Citations: 36     Fields:    Translation:HumansCells
  48. Liu LX, Heveker N, Fackler OT, Arold S, Le Gall S, Janvier K, Peterlin BM, Dumas C, Schwartz O, Benichou S, Benarous R. Mutation of a conserved residue (D123) required for oligomerization of human immunodeficiency virus type 1 Nef protein abolishes interaction with human thioesterase and results in impairment of Nef biological functions. J Virol. 2000 Jun; 74(11):5310-9. PMID: 10799608.
    Citations: 52     Fields:    Translation:HumansCells
  49. Piguet V, Schwartz O, Le Gall S, Trono D. The downregulation of CD4 and MHC-I by primate lentiviruses: a paradigm for the modulation of cell surface receptors. Immunol Rev. 1999 Apr; 168:51-63. PMID: 10399064.
    Citations: 73     Fields:    Translation:HumansAnimalsCells
  50. Le Gall S, Erdtmann L, Benichou S, Berlioz-Torrent C, Liu L, Benarous R, Heard JM, Schwartz O. Nef interacts with the mu subunit of clathrin adaptor complexes and reveals a cryptic sorting signal in MHC I molecules. Immunity. 1998 Apr; 8(4):483-95. PMID: 9586638.
    Citations: 142     Fields:    Translation:HumansCells
  51. Amara A, Gall SL, Schwartz O, Salamero J, Montes M, Loetscher P, Baggiolini M, Virelizier JL, Arenzana-Seisdedos F. HIV coreceptor downregulation as antiviral principle: SDF-1alpha-dependent internalization of the chemokine receptor CXCR4 contributes to inhibition of HIV replication. J Exp Med. 1997 Jul 07; 186(1):139-46. PMID: 9207008.
    Citations: 156     Fields:    Translation:HumansAnimalsCells
  52. Liu LX, Margottin F, Le Gall S, Schwartz O, Selig L, Benarous R, Benichou S. Binding of HIV-1 Nef to a novel thioesterase enzyme correlates with Nef-mediated CD4 down-regulation. J Biol Chem. 1997 May 23; 272(21):13779-85. PMID: 9153233.
    Citations: 22     Fields:    Translation:HumansCells
  53. Le Gall S, Prevost MC, Heard JM, Schwartz O. Human immunodeficiency virus type I Nef independently affects virion incorporation of major histocompatibility complex class I molecules and virus infectivity. Virology. 1997 Mar 03; 229(1):295-301. PMID: 9123874.
    Citations: 22     Fields:    Translation:HumansCells
  54. Le Gall S, Heard JM, Schwartz O. Analysis of Nef-induced MHC-I endocytosis. Res Virol. 1997 Jan-Feb; 148(1):43-7. PMID: 9017833.
    Citations: 6     Fields:    Translation:HumansCells
  55. Schwartz O, Maréchal V, Le Gall S, Lemonnier F, Heard JM. Endocytosis of major histocompatibility complex class I molecules is induced by the HIV-1 Nef protein. Nat Med. 1996 Mar; 2(3):338-42. PMID: 8612235.
    Citations: 407     Fields:    Translation:HumansCells
  56. Naffakh N, Le Gall S, Danos O, Heard JM, Cournot G, Motoyoshi K, Vilmer E. Macrophage colony-stimulating factor: serum levels and cDNA structure in malignant osteopetrosis. Blood. 1993 May 15; 81(10):2817-8. PMID: 8490189.
    Citations:    Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.