Harvard Catalyst Profiles

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Lorelei Ann Mucci, SC.D.

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Mentoring
Available: 10/22/18, Expires: 05/20/19

Our group has several ongoing projects in prostate cancer that are aimed at translation to primary and secondary prevention of the disease. Our group integrates a range of biomarkers -- genetic factors, tumor biomarkers, circulating markers -- to address key questions in prostate cancer etiology as well as prediction and prognostication. The work is highly interdisciplinary, with prostate cancer collaborators across the Dana Farber/Harvard Cancer Center as well as with international colleagues affiliated with the Nordic Twin Study of Cancer as well as the International Registry for Men with Advanced Prostate Cancer (IRONMAN). We have a number of ongoing research projects on which a student could take the lead or contribute depending on interests and background, particularly related to improving risk prediction for lethal prostate cancer, developing genetic signatures for prostate cancer risk factors, analyzing gene expression profiling data, and metabolomics. The student would work closely with a faculty member as well as students, postdocs, research scientists, and junior faculty within the group to define a research question, perform literature review and statistical analyses, interpret results, review medical records for study participants, and draft and publish manuscripts.

Muscarinic Stress Pathway Implicated in the Racial Disparities of Prostate Cancer
Summer, 11/27/18 - 08/31/18
The effect of SRD5a1/2 genetic variants on the TMPRSS2:ERG fusion in prostate cancer progression
Summer, 06/15/09 - 08/14/09
The Implications of TMPRSS2:ERG Fusion Status In Prostate Cancer
Summer, 07/01/15 - 04/01/16

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01CA202690 (MUCCI, LORELEI) Jan 20, 2016 - Dec 31, 2019
    NIH/NCI
    Circadian Disruption and Risk of Prostate Cancer in a Multiethnic Cohort
    Role: Principal Investigator
  2. U01CA167552 (WILLETT, WALTER C.) Aug 21, 2012 - Jul 31, 2022
    NIH/NCI
    Cancer Epidemiology Cohort in Male Health Professionals
    Role: Co-Principal Investigator
  3. R01CA136578 (MUCCI, LORELEI) Mar 3, 2009 - Jan 31, 2015
    NIH/NCI
    Sex-Hormones and the TMPRSS2: ERG Fusion in Prostate Cancer Progression
    Role: Principal Investigator
  4. P50CA090381 (LODA, MASSIMO) Apr 1, 2001 - Jun 30, 2018
    NIH/NCI
    DF/HCC SPORE in Prostate Cancer
    Role: Co-Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Malik VS, Guasch-Ferre M, Hu FB, Townsend MK, Zeleznik OA, Eliassen AH, Tworoger SS, Karlson EW, Costenbader KH, Ascherio A, Wilson KM, Mucci LA, Giovannucci EL, Fuchs CS, Bao Y. Identification of Plasma Lipid Metabolites Associated with Nut Consumption in US Men and Women. J Nutr. 2019 May 16. PMID: 31095304.
    Citations:    
  2. Stopsack KH, Whittaker CA, Gerke TA, Loda M, Kantoff PW, Mucci LA, Amon A. Aneuploidy drives lethal progression in prostate cancer. Proc Natl Acad Sci U S A. 2019 May 13. PMID: 31085648.
    Citations:    
  3. Campbell PT, Ambrosone CB, Nishihara R, Aerts HJWL, Bondy M, Chatterjee N, Garcia-Closas M, Giannakis M, Golden JA, Heng YJ, Kip NS, Koshiol J, Liu XS, Lopes-Ramos CM, Mucci LA, Nowak JA, Phipps AI, Quackenbush J, Schoen RE, Sholl LM, Tamimi RM, Wang M, Weijenberg MP, Wu CJ, Wu K, Yao S, Yu KH, Zhang X, Rebbeck TR, Ogino S. Proceedings of the fourth international molecular pathological epidemiology (MPE) meeting. Cancer Causes Control. 2019 May 08. PMID: 31069578.
    Citations:    
  4. Downer MK, Kenfield SA, Stampfer MJ, Wilson KM, Dickerman BA, Giovannucci EL, Rimm EB, Wang M, Mucci LA, Willett WC, Chan JM, Van Blarigan EL. Alcohol Intake and Risk of Lethal Prostate Cancer in the Health Professionals Follow-Up Study. J Clin Oncol. 2019 Apr 26; JCO1802462. PMID: 31026211.
    Citations:    
  5. Skytthe A, Harris JR, Czene K, Mucci L, Adami HO, Christensen K, Hjelmborg J, Holm NV, Nilsen TS, Kaprio J, Pukkala E. Cancer Incidence and Mortality in 260,000 Nordic Twins With 30,000 Prospective Cancers. Twin Res Hum Genet. 2019 Apr 25; 1-9. PMID: 31020942.
    Citations:    
  6. Heath EI, Nanus DM, Slovin S, Strand C, Higano C, Simons VH, Johnson C, Kyriakopoulos CE, Reichert ZR, Lory S, George DJ, Mucci LA, Marcus JD, Trendel JA, Bock CH. Prostate Cancer National Summit's Call to Action. Clin Genitourin Cancer. 2019 Apr 16. PMID: 31085057.
    Citations:    
  7. Watts EL, Perez-Cornago A, Appleby PN, Albanes D, Ardanaz E, Black A, Bueno-de-Mesquita HB, Chan JM, Chen C, Chubb SAP, Cook MB, Deschasaux M, Donovan JL, English DR, Flicker L, Freedman ND, Galan P, Giles GG, Giovannucci EL, Gunter MJ, Habel LA, Häggström C, Haiman C, Hamdy FC, Hercberg S, Holly JM, Huang J, Huang WY, Johansson M, Kaaks R, Kubo T, Lane JA, Layne TM, Le Marchand L, Martin RM, Metter EJ, Mikami K, Milne RL, Morris HA, Mucci LA, Neal DE, Neuhouser ML, Oliver SE, Overvad K, Ozasa K, Pala V, Pernar CH, Pollak M, Rowlands MA, Schaefer CA, Schenk JM, Stattin P, Tamakoshi A, Thysell E, Touvier M, Trichopoulou A, Tsilidis KK, Van Den Eeden SK, Weinstein SJ, Wilkens L, Yeap BB, Key TJ, Allen NE, Travis RC. The associations of anthropometric, behavioural and sociodemographic factors with circulating concentrations of IGF-I, IGF-II, IGFBP-1, IGFBP-2 and IGFBP-3 in a pooled analysis of 16,024 men from 22 studies. Int J Cancer. 2019 Mar 15. PMID: 30873591.
    Citations:    
  8. Khan NA, Stopsack KH, Allott EH, Gerke T, Giovannucci EL, Mucci LA, Kantoff PW. Intratumoral Sterol-27-Hydroxylase (CYP27A1) Expression in Relation to Cholesterol Synthesis and Vitamin D Signaling and Its Association with Lethal Prostate Cancer. Cancer Epidemiol Biomarkers Prev. 2019 Mar 13. PMID: 30867220.
    Citations:    
  9. Hang D, Kværner AS, Ma W, Hu Y, Tabung FK, Nan H, Hu Z, Shen H, Mucci LA, Chan AT, Giovannucci EL, Song M. Coffee consumption and plasma biomarkers of metabolic and inflammatory pathways in US health professionals. Am J Clin Nutr. 2019 Mar 01; 109(3):635-647. PMID: 30834441.
    Citations:    
  10. Dickerman BA, Giovannucci E, Pernar CH, Mucci LA, Hernán MA. Guideline-Based Physical Activity and Survival Among US Men With Nonmetastatic Prostate Cancer. Am J Epidemiol. 2019 Mar 01; 188(3):579-586. PMID: 30496346.
    Citations:    Fields:    
  11. Torfadottir JE, Aspelund T, Valdimarsdottir UA, Cotch MF, Tryggvadottir L, Harris TB, Gudnason V, Adami HO, Mucci LA, Giovannucci EL, Stampfer MJ, Steingrimsdottir L. Pre-diagnostic 25-hydroxyvitamin D levels and survival in cancer patients. Cancer Causes Control. 2019 Apr; 30(4):333-342. PMID: 30805814.
    Citations:    
  12. Schumacher FR, Olama AAA, Berndt SI, Benlloch S, Ahmed M, Saunders EJ, Dadaev T, Leongamornlert D, Anokian E, Cieza-Borrella C, Goh C, Brook MN, Sheng X, Fachal L, Dennis J, Tyrer J, Muir K, Lophatananon A, Stevens VL, Gapstur SM, Carter BD, Tangen CM, Goodman PJ, Thompson IM, Batra J, Chambers S, Moya L, Clements J, Horvath L, Tilley W, Risbridger GP, Gronberg H, Aly M, Nordström T, Pharoah P, Pashayan N, Schleutker J, Tammela TLJ, Sipeky C, Auvinen A, Albanes D, Weinstein S, Wolk A, Håkansson N, West CML, Dunning AM, Burnet N, Mucci LA, Giovannucci E, Andriole GL, Cussenot O, Cancel-Tassin G, Koutros S, Beane Freeman LE, Sorensen KD, Orntoft TF, Borre M, Maehle L, Grindedal EM, Neal DE, Donovan JL, Hamdy FC, Martin RM, Travis RC, Key TJ, Hamilton RJ, Fleshner NE, Finelli A, Ingles SA, Stern MC, Rosenstein BS, Kerns SL, Ostrer H, Lu YJ, Zhang HW, Feng N, Mao X, Guo X, Wang G, Sun Z, Giles GG, Southey MC, MacInnis RJ, FitzGerald LM, Kibel AS, Drake BF, Vega A, Gómez-Caamaño A, Szulkin R, Eklund M, Kogevinas M, Llorca J, Castaño-Vinyals G, Penney KL, Stampfer M, Park JY, Seller