Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Bruce Gorton Jenkins, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AG070257 (CHENG, LEO L) Feb 15, 2021 - Jan 31, 2026
    Metabolomic characterization of normal aging and Alzheimer's disease under anesthesia- surgery stimuli
    Role: Co-Principal Investigator
  2. RF1AG069228 (JENKINS, BRUCE G) Sep 1, 2020 - Aug 31, 2024
    Protective roles of taurine in Alzheimer's disease brain
    Role: Principal Investigator
  3. R01AG056032 (DEDEOGLU, ALPASLAN) Sep 1, 2017 - Jun 30, 2022
    Sphingosine-1-phosphate induced modulation of inflammation in aging and Alzheimer's disease
    Role: Co-Principal Investigator
  4. RF1AG056032 (DEDEOGLU, ALPASLAN) Sep 1, 2017 - Mar 31, 2022
    Sphingosine-1-phosphate induced modulation of inflammation in aging and Alzheimer's disease
    Role: Co-Principal Investigator
  5. S10RR022976 (JENKINS, BRUCE) Jul 15, 2007 - Jul 14, 2008
    Combined MRI/PET Imager for Simultaneous Acquisition of PET/MRI Data
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Hone-Blanchet A, Antal B, McMahon L, Lithen A, Smith NA, Stufflebeam S, Yen YF, Lin A, Jenkins BG, Mujica-Parodi LR, Ratai EM. Acute administration of ketone beta-hydroxybutyrate downregulates 7T proton magnetic resonance spectroscopy-derived levels of anterior and posterior cingulate GABA and glutamate in healthy adults. Neuropsychopharmacology. 2022 Aug 22. PMID: 35995971.
    Citations:    Fields:    
  2. Mealer RG, Jenkins BG, Chen CY, Daly MJ, Ge T, Lehoux S, Marquardt T, Palmer CD, Park JH, Parsons PJ, Sackstein R, Williams SE, Cummings RD, Scolnick EM, Smoller JW. The schizophrenia risk locus in SLC39A8 alters brain metal transport and plasma glycosylation. Sci Rep. 2020 08 04; 10(1):13162. PMID: 32753748.
    Citations: 19     Fields:    Translation:HumansCells
  3. Carreras I, Aytan N, Choi JK, Tognoni CM, Kowall NW, Jenkins BG, Dedeoglu A. Dual dose-dependent effects of fingolimod in a mouse model of Alzheimer's disease. Sci Rep. 2019 07 29; 9(1):10972. PMID: 31358793.
    Citations: 18     Fields:    Translation:AnimalsCells
  4. Carreras I, Aytan N, Mellott T, Choi JK, Lehar M, Crabtree L, Leite-Morris K, Jenkins BG, Blusztajn JK, Dedeoglu A. Corrigendum to "Anxiety, neuroinflammation, cholinergic and GABAergic abnormalities are early markers of Gulf War illness in a mouse model of the disease" [Brain Res. 1681 (2018) 34-43]. Brain Res. 2018 06 01; 1688:113-115. PMID: 29526415.
    Citations:    Fields:    
  5. Choi JK, Lim G, Chen YI, Jenkins BG. Abstinence to chronic methamphetamine switches connectivity between striatal, hippocampal and sensorimotor regions and increases cerebral blood volume response. Neuroimage. 2018 07 01; 174:364-379. PMID: 29518566.
    Citations: 4     Fields:    Translation:Animals
  6. Aytan N, Choi JK, Carreras I, Crabtree L, Nguyen B, Lehar M, Blusztajn JK, Jenkins BG, Dedeoglu A. Protective effects of 7,8-dihydroxyflavone on neuropathological and neurochemical changes in a mouse model of Alzheimer's disease. Eur J Pharmacol. 2018 Jun 05; 828:9-17. PMID: 29510124; PMCID: PMC5971844.
    Citations: 17     Fields:    Translation:AnimalsCells
  7. Carreras I, Aytan N, Mellott T, Choi JK, Lehar M, Crabtree L, Leite-Morris K, Jenkins BG, Blusztajn JK, Dedeoglu A. Anxiety, neuroinflammation, cholinergic and GABAergic abnormalities are early markers of Gulf War illness in a mouse model of the disease. Brain Res. 2018 02 15; 1681:34-43. PMID: 29277710; PMCID: PMC5971846.
    Citations: 14     Fields:    Translation:AnimalsCells
  8. Kantarci A, Aytan N, Palaska I, Stephens D, Crabtree L, Benincasa C, Jenkins BG, Carreras I, Dedeoglu A. Combined administration of resolvin E1 and lipoxin A4 resolves inflammation in a murine model of Alzheimer's disease. Exp Neurol. 2018 02; 300:111-120. PMID: 29126887.
    Citations: 50     Fields:    Translation:Animals
  9. Aytan N, Choi JK, Carreras I, Brinkmann V, Kowall NW, Jenkins BG, Dedeoglu A. Fingolimod modulates multiple neuroinflammatory markers in a mouse model of Alzheimer's disease. Sci Rep. 2016 04 27; 6:24939. PMID: 27117087.
    Citations: 57     Fields:    Translation:Animals
  10. Jenkins BG, Zhu A, Poutiainen P, Choi JK, Kil KE, Zhang Z, Kuruppu D, Aytan N, Dedeoglu A, Brownell AL. Functional modulation of G-protein coupled receptors during Parkinson disease-like neurodegeneration. Neuropharmacology. 2016 09; 108:462-73. PMID: 26581500.
    Citations: 1     Fields:    Translation:AnimalsCells
  11. Choi JK, Zhu A, Jenkins BG, Hattori S, Kil KE, Takagi T, Ishii S, Miyakawa T, Brownell AL. Combined behavioral studies and in vivo imaging of inflammatory response and expression of mGlu5 receptors in schnurri-2 knockout mice. Neurosci Lett. 2015 Nov 16; 609:159-64. PMID: 26483320.
    Citations: 4     Fields:    Translation:Animals
  12. Choi JK, Carreras I, Aytan N, Jenkins-Sahlin E, Dedeoglu A, Jenkins BG. The effects of aging, housing and ibuprofen treatment on brain neurochemistry in a triple transgene Alzheimer's disease mouse model using magnetic resonance spectroscopy and imaging. Brain Res. 2014 Nov 24; 1590:85-96. PMID: 25301691.
    Citations: 13     Fields:    Translation:HumansAnimals
  13. Lu H, Jenkins BG, Stein EA. Introduction to the special issue on neuroimaging in neuropharmacology. Neuropharmacology. 2014 Sep; 84:63-4. PMID: 24859606.
    Citations: 1     Fields:    Translation:HumansAnimals
  14. Korkmaz OT, Aytan N, Carreras I, Choi JK, Kowall NW, Jenkins BG, Dedeoglu A. 7,8-Dihydroxyflavone improves motor performance and enhances lower motor neuronal survival in a mouse model of amyotrophic lateral sclerosis. Neurosci Lett. 2014 Apr 30; 566:286-91. PMID: 24637017.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  15. Mandeville JB, Liu CH, Vanduffel W, Marota JJ, Jenkins BG. Data collection and analysis strategies for phMRI. Neuropharmacology. 2014 Sep; 84:65-78. PMID: 24613447.
    Citations: 9     Fields:    Translation:HumansAnimals
  16. Carreras I, McKee AC, Choi JK, Aytan N, Kowall NW, Jenkins BG, Dedeoglu A. R-flurbiprofen improves tau, but not Aß pathology in a triple transgenic model of Alzheimer's disease. Brain Res. 2013 Dec 06; 1541:115-27. PMID: 24161403.
    Citations: 16     Fields:    Translation:HumansAnimals
  17. Aytan N, Choi JK, Carreras I, Kowall NW, Jenkins BG, Dedeoglu A. Combination therapy in a transgenic model of Alzheimer's disease. Exp Neurol. 2013 Dec; 250:228-238. PMID: 24120437.
    Citations: 18     Fields:    Translation:Animals
  18. Mandeville JB, Sander CYM, Jenkins BG, Hooker JM, Catana C, Vanduffel W, Alpert NM, Rosen BR, Normandin MD. A receptor-based model for dopamine-induced fMRI signal. Neuroimage. 2013 Jul 15; 75:46-57. PMID: 23466936.
    Citations: 33     Fields:    Translation:HumansAnimals
  19. Jenkins BG. Pharmacologic magnetic resonance imaging (phMRI): imaging drug action in the brain. Neuroimage. 2012 Aug 15; 62(2):1072-85. PMID: 22495143.
    Citations: 46     Fields:    Translation:HumansAnimals
  20. Chen YI, Famous K, Xu H, Choi JK, Mandeville JB, Schmidt HD, Pierce RC, Jenkins BG. Cocaine self-administration leads to alterations in temporal responses to cocaine challenge in limbic and motor circuitry. Eur J Neurosci. 2011 Sep; 34(5):800-15. PMID: 21896062.
    Citations: 12     Fields:    Translation:HumansAnimals
  21. Mandeville JB, Choi JK, Jarraya B, Rosen BR, Jenkins BG, Vanduffel W. fMRI of cocaine self-administration in macaques reveals functional inhibition of basal ganglia. Neuropsychopharmacology. 2011 May; 36(6):1187-98. PMID: 21307843.
    Citations: 27     Fields:    Translation:Animals
  22. Choi JK, Mandeville JB, Chen YI, Grundt P, Sarkar SK, Newman AH, Jenkins BG. Imaging brain regional and cortical laminar effects of selective D3 agonists and antagonists. Psychopharmacology (Berl). 2010 Sep; 212(1):59-72. PMID: 20628733.
    Citations: 15     Fields:    Translation:Animals
  23. Chen YI, Choi JK, Xu H, Ren J, Andersen SL, Jenkins BG. Pharmacologic neuroimaging of the ontogeny of dopamine receptor function. Dev Neurosci. 2010 Jul; 32(2):125-38. PMID: 20523024.
    Citations: 28     Fields:    Translation:HumansAnimals
  24. Choi JK, Carreras I, Dedeoglu A, Jenkins BG. Detection of increased scyllo-inositol in brain with magnetic resonance spectroscopy after dietary supplementation in Alzheimer's disease mouse models. Neuropharmacology. 2010 Sep-Oct; 59(4-5):353-7. PMID: 20399219.
    Citations: 13     Fields:    Translation:HumansAnimals
  25. Choi JK, Dedeoglu A, Jenkins BG. Longitudinal monitoring of motor neuron circuitry in FALS rats using in-vivo phMRI. Neuroreport. 2010 Feb 17; 21(3):157-62. PMID: 20118741.
    Citations:    Fields:    Translation:AnimalsCells
  26. Wu CL, Jordan KW, Ratai EM, Sheng J, Adkins CB, Defeo EM, Jenkins BG, Ying L, McDougal WS, Cheng LL. Metabolomic imaging for human prostate cancer detection. Sci Transl Med. 2010 Jan 27; 2(16):16ra8. PMID: 20371475.
    Citations: 18     Fields:    Translation:Humans
  27. Carreras I, Yuruker S, Aytan N, Hossain L, Choi JK, Jenkins BG, Kowall NW, Dedeoglu A. Moderate exercise delays the motor performance decline in a transgenic model of ALS. Brain Res. 2010 Feb 08; 1313:192-201. PMID: 19968977.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  28. Choi JK, Küstermann E, Dedeoglu A, Jenkins BG. Magnetic resonance spectroscopy of regional brain metabolite markers in FALS mice and the effects of dietary creatine supplementation. Eur J Neurosci. 2009 Dec; 30(11):2143-50. PMID: 19930399.
    Citations: 21     Fields:    Translation:Animals
  29. Ren J, Xu H, Choi JK, Jenkins BG, Chen YI. Dopaminergic response to graded dopamine concentration elicited by four amphetamine doses. Synapse. 2009 Sep; 63(9):764-72. PMID: 19484725.
    Citations: 29     Fields:    Translation:AnimalsCells
  30. Choi JK, Jenkins BG, Carreras I, Kaymakcalan S, Cormier K, Kowall NW, Dedeoglu A. Anti-inflammatory treatment in AD mice protects against neuronal pathology. Exp Neurol. 2010 Jun; 223(2):377-84. PMID: 19679126.
    Citations: 29     Fields:    Translation:HumansAnimals
  31. Astradsson A, Jenkins BG, Choi JK, Hallett PJ, Levesque MA, McDowell JS, Brownell AL, Spealman RD, Isacson O. The blood-brain barrier is intact after levodopa-induced dyskinesias in parkinsonian primates--evidence from in vivo neuroimaging studies. Neurobiol Dis. 2009 Sep; 35(3):348-51. PMID: 19501164.
    Citations: 15     Fields:    Translation:Animals
  32. Henchcliffe C, Shungu DC, Mao X, Huang C, Nirenberg MJ, Jenkins BG, Beal MF. Multinuclear magnetic resonance spectroscopy for in vivo assessment of mitochondrial dysfunction in Parkinson's disease. Ann N Y Acad Sci. 2008 Dec; 1147:206-20. PMID: 19076443.
    Citations: 29     Fields:    Translation:HumansCells
  33. McKee AC, Carreras I, Hossain L, Ryu H, Klein WL, Oddo S, LaFerla FM, Jenkins BG, Kowall NW, Dedeoglu A. Ibuprofen reduces Abeta, hyperphosphorylated tau and memory deficits in Alzheimer mice. Brain Res. 2008 May 01; 1207:225-36. PMID: 18374906.
    Citations: 89     Fields:    Translation:HumansAnimalsCells
  34. Chen YI, Ren J, Wang FN, Xu H, Mandeville JB, Kim Y, Rosen BR, Jenkins BG, Hui KK, Kwong KK. Inhibition of stimulated dopamine release and hemodynamic response in the brain through electrical stimulation of rat forepaw. Neurosci Lett. 2008 Feb 06; 431(3):231-5. PMID: 18178315; PMCID: PMC2254524.
    Citations: 9     Fields:    Translation:Animals
  35. Stack EC, Dedeoglu A, Smith KM, Cormier K, Kubilus JK, Bogdanov M, Matson WR, Yang L, Jenkins BG, Luthi-Carter R, Kowall NW, Hersch SM, Beal MF, Ferrante RJ. Neuroprotective effects of synaptic modulation in Huntington's disease R6/2 mice. J Neurosci. 2007 Nov 21; 27(47):12908-15. PMID: 18032664.
    Citations: 34     Fields:    Translation:AnimalsCells
  36. Liu PK, Mandeville JB, Jenkins BG, Kim YR, Liu CH. Transcription MRI: a new view of the living brain. Neuroscientist. 2008 Oct; 14(5):503-20. PMID: 18024855.
    Citations: 6     Fields:    Translation:HumansCells
  37. Grundt P, Prevatt KM, Cao J, Taylor M, Floresca CZ, Choi JK, Jenkins BG, Luedtke RR, Newman AH. Heterocyclic analogues of N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)arylcarboxamides with functionalized linking chains as novel dopamine D3 receptor ligands: potential substance abuse therapeutic agents. J Med Chem. 2007 Aug 23; 50(17):4135-46. PMID: 17672446.
    Citations: 63     Fields:    Translation:HumansAnimalsCells
  38. Sánchez-Pernaute R, Jenkins BG, Choi JK, Iris Chen YC, Isacson O. In vivo evidence of D3 dopamine receptor sensitization in parkinsonian primates and rodents with l-DOPA-induced dyskinesias. Neurobiol Dis. 2007 Aug; 27(2):220-7. PMID: 17588764; PMCID: PMC2674779.
    Citations: 24     Fields:    Translation:Animals
  39. Choi JK, Dedeoglu A, Jenkins BG. Application of MRS to mouse models of neurodegenerative illness. NMR Biomed. 2007 May; 20(3):216-37. PMID: 17451183.
    Citations: 50     Fields:    Translation:HumansAnimals
  40. Kraft E, Chen AW, Flaherty AW, Blood AJ, Kwong KK, Jenkins BG. The role of the basal ganglia in bimanual coordination. Brain Res. 2007 Jun 02; 1151:62-73. PMID: 17448452.
    Citations: 19     Fields:    Translation:Humans
  41. Choi JK, Mandeville JB, Chen YI, Kim YR, Jenkins BG. High resolution spatial mapping of nicotine action using pharmacologic magnetic resonance imaging. Synapse. 2006 Aug; 60(2):152-7. PMID: 16715493.
    Citations: 11     Fields:    Translation:Animals
  42. Choi JK, Chen YI, Hamel E, Jenkins BG. Brain hemodynamic changes mediated by dopamine receptors: Role of the cerebral microvasculature in dopamine-mediated neurovascular coupling. Neuroimage. 2006 Apr 15; 30(3):700-12. PMID: 16459104.
    Citations: 98     Fields:    Translation:Animals
  43. Hersch SM, Gevorkian S, Marder K, Moskowitz C, Feigin A, Cox M, Como P, Zimmerman C, Lin M, Zhang L, Ulug AM, Beal MF, Matson W, Bogdanov M, Ebbel E, Zaleta A, Kaneko Y, Jenkins B, Hevelone N, Zhang H, Yu H, Schoenfeld D, Ferrante R, Rosas HD. Creatine in Huntington disease is safe, tolerable, bioavailable in brain and reduces serum 8OH2'dG. Neurology. 2006 Jan 24; 66(2):250-2. PMID: 16434666.
    Citations: 105     Fields:    Translation:Humans
  44. Chen YC, Choi JK, Andersen SL, Rosen BR, Jenkins BG. Mapping dopamine D2/D3 receptor function using pharmacological magnetic resonance imaging. Psychopharmacology (Berl). 2005 Aug; 180(4):705-15. PMID: 15536545.
    Citations: 43     Fields:    Translation:Animals
  45. Sánchez-Pernaute R, Brownell AL, Jenkins BG, Isacson O. Insights into Parkinson's disease models and neurotoxicity using non-invasive imaging. Toxicol Appl Pharmacol. 2005 Sep 01; 207(2 Suppl):251-6. PMID: 15979668.
    Citations: 3     Fields:    Translation:HumansAnimals
  46. Jenkins BG, Andreassen OA, Dedeoglu A, Leavitt B, Hayden M, Borchelt D, Ross CA, Ferrante RJ, Beal MF. Effects of CAG repeat length, HTT protein length and protein context on cerebral metabolism measured using magnetic resonance spectroscopy in transgenic mouse models of Huntington's disease. J Neurochem. 2005 Oct; 95(2):553-62. PMID: 16135087.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  47. Chen YI, Choi JK, Jenkins BG. Mapping interactions between dopamine and adenosine A2a receptors using pharmacologic MRI. Synapse. 2005 Feb; 55(2):80-8. PMID: 15529335.
    Citations: 5     Fields:    Translation:Animals
  48. Mandeville JB, Jenkins BG, Chen YC, Choi JK, Kim YR, Belen D, Liu C, Kosofsky BE, Marota JJ. Exogenous contrast agent improves sensitivity of gradient-echo functional magnetic resonance imaging at 9.4 T. Magn Reson Med. 2004 Dec; 52(6):1272-81. PMID: 15562489.
    Citations: 43     Fields:    Translation:Animals
  49. Jenkins BG, Sanchez-Pernaute R, Brownell AL, Chen YC, Isacson O. Mapping dopamine function in primates using pharmacologic magnetic resonance imaging. J Neurosci. 2004 Oct 27; 24(43):9553-60. PMID: 15509742; PMCID: PMC2629666.
    Citations: 41     Fields:    Translation:Animals
  50. Dedeoglu A, Choi JK, Cormier K, Kowall NW, Jenkins BG. Magnetic resonance spectroscopic analysis of Alzheimer's disease mouse brain that express mutant human APP shows altered neurochemical profile. Brain Res. 2004 Jun 25; 1012(1-2):60-5. PMID: 15158161.
    Citations: 64     Fields:    Translation:HumansAnimals
  51. Brownell AL, Chen YI, Yu M, Wang X, Dedeoglu A, Cicchetti F, Jenkins BG, Beal MF. 3-Nitropropionic acid-induced neurotoxicity--assessed by ultra high resolution positron emission tomography with comparison to magnetic resonance spectroscopy. J Neurochem. 2004 Jun; 89(5):1206-14. PMID: 15147513.
    Citations: 7     Fields:    Translation:Animals
  52. Blood AJ, Flaherty AW, Choi JK, Hochberg FH, Greve DN, Bonmassar G, Rosen BR, Jenkins BG. Basal ganglia activity remains elevated after movement in focal hand dystonia. Ann Neurol. 2004 May; 55(5):744-8. PMID: 15122718.
    Citations: 36     Fields:    Translation:Humans
  53. Brownell AL, Canales K, Chen YI, Jenkins BG, Owen C, Livni E, Yu M, Cicchetti F, Sanchez-Pernaute R, Isacson O. Mapping of brain function after MPTP-induced neurotoxicity in a primate Parkinson's disease model. Neuroimage. 2003 Oct; 20(2):1064-75. PMID: 14568476.
    Citations: 22     Fields:    Translation:Animals
  54. Rosas HD, Koroshetz WJ, Chen YI, Skeuse C, Vangel M, Cudkowicz ME, Caplan K, Marek K, Seidman LJ, Makris N, Jenkins BG, Goldstein JM. Evidence for more widespread cerebral pathology in early HD: an MRI-based morphometric analysis. Neurology. 2003 May 27; 60(10):1615-20. PMID: 12771251.
    Citations: 161     Fields:    Translation:Humans
  55. Rosas HD, Liu AK, Hersch S, Glessner M, Ferrante RJ, Salat DH, van der Kouwe A, Jenkins BG, Dale AM, Fischl B. Regional and progressive thinning of the cortical ribbon in Huntington's disease. Neurology. 2002 Mar 12; 58(5):695-701. PMID: 11889230.
    Citations: 426     Fields:    Translation:Humans
  56. Ferrante RJ, Andreassen OA, Dedeoglu A, Ferrante KL, Jenkins BG, Hersch SM, Beal MF. Therapeutic effects of coenzyme Q10 and remacemide in transgenic mouse models of Huntington's disease. J Neurosci. 2002 Mar 01; 22(5):1592-9. PMID: 11880489; PMCID: PMC6758854.
    Citations: 126     Fields:    Translation:HumansAnimals
  57. Bjorklund LM, Sánchez-Pernaute R, Chung S, Andersson T, Chen IY, McNaught KS, Brownell AL, Jenkins BG, Wahlestedt C, Kim KS, Isacson O. Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model. Proc Natl Acad Sci U S A. 2002 Feb 19; 99(4):2344-9. PMID: 11782534; PMCID: PMC122367.
    Citations: 284     Fields:    Translation:AnimalsCells
  58. Chen YC, Mandeville JB, Nguyen TV, Talele A, Cavagna F, Jenkins BG. Improved mapping of pharmacologically induced neuronal activation using the IRON technique with superparamagnetic blood pool agents. J Magn Reson Imaging. 2001 Nov; 14(5):517-24. PMID: 11747003.
    Citations: 33     Fields:    Translation:Animals
  59. Rosas HD, Goodman J, Chen YI, Jenkins BG, Kennedy DN, Makris N, Patti M, Seidman LJ, Beal MF, Koroshetz WJ. Striatal volume loss in HD as measured by MRI and the influence of CAG repeat. Neurology. 2001 Sep 25; 57(6):1025-8. PMID: 11571328.
    Citations: 58     Fields:    Translation:HumansCells
  60. Andreassen OA, Dedeoglu A, Ferrante RJ, Jenkins BG, Ferrante KL, Thomas M, Friedlich A, Browne SE, Schilling G, Borchelt DR, Hersch SM, Ross CA, Beal MF. Creatine increase survival and delays motor symptoms in a transgenic animal model of Huntington's disease. Neurobiol Dis. 2001 Jun; 8(3):479-91. PMID: 11447996.
    Citations: 81     Fields:    Translation:AnimalsCells
  61. Andreassen OA, Jenkins BG, Dedeoglu A, Ferrante KL, Bogdanov MB, Kaddurah-Daouk R, Beal MF. Increases in cortical glutamate concentrations in transgenic amyotrophic lateral sclerosis mice are attenuated by creatine supplementation. J Neurochem. 2001 Apr; 77(2):383-90. PMID: 11299300.
    Citations: 32     Fields:    Translation:Animals
  62. Mandeville JB, Jenkins BG, Kosofsky BE, Moskowitz MA, Rosen BR, Marota JJ. Regional sensitivity and coupling of BOLD and CBV changes during stimulation of rat brain. Magn Reson Med. 2001 Mar; 45(3):443-7. PMID: 11241702.
    Citations: 46     Fields:    Translation:Animals
  63. Scholz VH, Flaherty AW, Kraft E, Keltner JR, Kwong KK, Chen YI, Rosen BR, Jenkins BG. Laterality, somatotopy and reproducibility of the basal ganglia and motor cortex during motor tasks. Brain Res. 2000 Oct 06; 879(1-2):204-15. PMID: 11011024.
    Citations: 28     Fields:    Translation:Humans
  64. Zaharchuk G, Yamada M, Sasamata M, Jenkins BG, Moskowitz MA, Rosen BR. Is all perfusion-weighted magnetic resonance imaging for stroke equal? The temporal evolution of multiple hemodynamic parameters after focal ischemia in rats correlated with evidence of infarction. J Cereb Blood Flow Metab. 2000 Sep; 20(9):1341-51. PMID: 10994856.
    Citations: 11     Fields:    Translation:HumansAnimals
  65. Ferrante RJ, Andreassen OA, Jenkins BG, Dedeoglu A, Kuemmerle S, Kubilus JK, Kaddurah-Daouk R, Hersch SM, Beal MF. Neuroprotective effects of creatine in a transgenic mouse model of Huntington's disease. J Neurosci. 2000 Jun 15; 20(12):4389-97. PMID: 10844007; PMCID: PMC6772461.
    Citations: 131     Fields:    Translation:HumansAnimalsCells
  66. Jenkins BG, Klivenyi P, Kustermann E, Andreassen OA, Ferrante RJ, Rosen BR, Beal MF. Nonlinear decrease over time in N-acetyl aspartate levels in the absence of neuronal loss and increases in glutamine and glucose in transgenic Huntington's disease mice. J Neurochem. 2000 May; 74(5):2108-19. PMID: 10800956.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  67. Nguyen TV, Brownell AL, Iris Chen YC, Livni E, Coyle JT, Rosen BR, Cavagna F, Jenkins BG. Detection of the effects of dopamine receptor supersensitivity using pharmacological MRI and correlations with PET. Synapse. 2000 Apr; 36(1):57-65. PMID: 10700026.
    Citations: 24     Fields:    Translation:Animals
  68. Jenkins BG, Kraft E. Magnetic resonance spectroscopy in toxic encephalopathy and neurodegeneration. Curr Opin Neurol. 1999 Dec; 12(6):753-60. PMID: 10676760.
    Citations: 6     Fields:    Translation:HumansAnimals
  69. Chen YI, Brownell AL, Galpern W, Isacson O, Bogdanov M, Beal MF, Livni E, Rosen BR, Jenkins BG. Detection of dopaminergic cell loss and neural transplantation using pharmacological MRI, PET and behavioral assessment. Neuroreport. 1999 Sep 29; 10(14):2881-6. PMID: 10549790.
    Citations: 23     Fields:    Translation:AnimalsCells
  70. Hill RA, Chiappa KH, Huang-Hellinger F, Jenkins BG. Hemodynamic and metabolic aspects of photosensitive epilepsy revealed by functional magnetic resonance imaging and magnetic resonance spectroscopy. Epilepsia. 1999 Jul; 40(7):912-20. PMID: 10403215.
    Citations: 5     Fields:    Translation:Humans
  71. Guimaraes AR, Baker JR, Jenkins BG, Lee PL, Weisskoff RM, Rosen BR, González RG. Echoplanar chemical shift imaging. Magn Reson Med. 1999 May; 41(5):877-82. PMID: 10332868.
    Citations: 6     Fields:    Translation:Humans
  72. Brownell AL, Jenkins BG, Isacson O. Dopamine imaging markers and predictive mathematical models for progressive degeneration in Parkinson's disease. Biomed Pharmacother. 1999 Apr; 53(3):131-40. PMID: 10349501.
    Citations: 6     Fields:    Translation:HumansAnimals
  73. Rosas HD, Koroshetz WJ, Jenkins BG, Chen YI, Hayden DL, Beal MF, Cudkowicz ME. Riluzole therapy in Huntington's disease (HD). Mov Disord. 1999 Mar; 14(2):326-30. PMID: 10091628.
    Citations: 18     Fields:    Translation:HumansCTClinical Trials
  74. Chiappa KH, Hill RA, Huang-Hellinger F, Jenkins BG. Photosensitive epilepsy studied by functional magnetic resonance imaging and magnetic resonance spectroscopy. Epilepsia. 1999; 40 Suppl 4:3-7. PMID: 10487166.
    Citations: 1     Fields:    Translation:Humans
  75. Jenkins BG, Chen YI, Kuestermann E, Makris NM, Nguyen TV, Kraft E, Brownell AL, Rosas HD, Kennedy DN, Rosen BR, Koroshetz WJ, Beal MF. An integrated strategy for evaluation of metabolic and oxidative defects in neurodegenerative illness using magnetic resonance techniques. Ann N Y Acad Sci. 1999; 893:214-42. PMID: 10672240.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  76. Zaharchuk G, Bogdanov AA, Marota JJ, Shimizu-Sasamata M, Weisskoff RM, Kwong KK, Jenkins BG, Weissleder R, Rosen BR. Continuous assessment of perfusion by tagging including volume and water extraction (CAPTIVE): a steady-state contrast agent technique for measuring blood flow, relative blood volume fraction, and the water extraction fraction. Magn Reson Med. 1998 Nov; 40(5):666-78. PMID: 9797148.
    Citations: 7     Fields:    Translation:Animals
  77. Brownell AL, Jenkins BG, Elmaleh DR, Deacon TW, Spealman RD, Isacson O. Combined PET/MRS brain studies show dynamic and long-term physiological changes in a primate model of Parkinson disease. Nat Med. 1998 Nov; 4(11):1308-12. PMID: 9809556.
    Citations: 27     Fields:    Translation:AnimalsCells
  78. Jenkins BG, Rosas HD, Chen YC, Makabe T, Myers R, MacDonald M, Rosen BR, Beal MF, Koroshetz WJ. 1H NMR spectroscopy studies of Huntington's disease: correlations with CAG repeat numbers. Neurology. 1998 May; 50(5):1357-65. PMID: 9595987.
    Citations: 58     Fields:    Translation:HumansCells
  79. Keltner JR, Wald LL, Ledden PJ, Chen YC, Matthews RT, Küestermann EH, Baker JR, Rosen BR, Jenkins BG. A localized double-quantum filter for the in vivo detection of brain glucose. Magn Reson Med. 1998 Apr; 39(4):651-6. PMID: 9543429.
    Citations: 4     Fields:    Translation:AnimalsCells
  80. Matthews RT, Yang L, Jenkins BG, Ferrante RJ, Rosen BR, Kaddurah-Daouk R, Beal MF. Neuroprotective effects of creatine and cyclocreatine in animal models of Huntington's disease. J Neurosci. 1998 Jan 01; 18(1):156-63. PMID: 9412496; PMCID: PMC6793381.
    Citations: 94     Fields:    Translation:Animals
  81. Cavagna FM, Maggioni F, Castelli PM, Daprà M, Imperatori LG, Lorusso V, Jenkins BG. Gadolinium chelates with weak binding to serum proteins. A new class of high-efficiency, general purpose contrast agents for magnetic resonance imaging. Invest Radiol. 1997 Dec; 32(12):780-96. PMID: 9406019.
    Citations: 52     Fields:    Translation:AnimalsCells
  82. Chen YC, Galpern WR, Brownell AL, Matthews RT, Bogdanov M, Isacson O, Keltner JR, Beal MF, Rosen BR, Jenkins BG. Detection of dopaminergic neurotransmitter activity using pharmacologic MRI: correlation with PET, microdialysis, and behavioral data. Magn Reson Med. 1997 Sep; 38(3):389-98. PMID: 9339439.
    Citations: 74     Fields:    Translation:Animals
  83. Makabe T, Edmister WB, Jenkins BG, Rosen BR. [Brain structures of reading Japanese words with functional MRI]. Nihon Rinsho. 1997 Jul; 55(7):1699-705. PMID: 9233012.
    Citations:    Fields:    Translation:Humans
  84. Matthews RT, Ferrante RJ, Jenkins BG, Browne SE, Goetz K, Berger S, Chen IY, Beal MF. Iodoacetate produces striatal excitotoxic lesions. J Neurochem. 1997 Jul; 69(1):285-9. PMID: 9202321.
    Citations: 7     Fields:    Translation:Animals
  85. Schulz JB, Panahian N, Chen YI, Beal MF, Moskowitz MA, Rosen BR, Jenkins BG. Facilitation of postischemic reperfusion with alpha-PBN: assessment using NMR and Doppler flow techniques. Am J Physiol. 1997 Apr; 272(4 Pt 2):H1986-95. PMID: 9139987.
    Citations: 7     Fields:    Translation:Animals
  86. Koroshetz WJ, Jenkins BG, Rosen BR, Beal MF. Energy metabolism defects in Huntington's disease and effects of coenzyme Q10. Ann Neurol. 1997 Feb; 41(2):160-5. PMID: 9029064.
    Citations: 98     Fields:    Translation:Humans
  87. Zaharchuk G, Hara H, Huang PL, Fishman MC, Moskowitz MA, Jenkins BG, Rosen BR. Neuronal nitric oxide synthase mutant mice show smaller infarcts and attenuated apparent diffusion coefficient changes in the peri-infarct zone during focal cerebral ischemia. Magn Reson Med. 1997 Feb; 37(2):170-5. PMID: 9001139.
    Citations: 10     Fields:    Translation:AnimalsCells
  88. Jenkins BG, Brouillet E, Chen YC, Storey E, Schulz JB, Kirschner P, Beal MF, Rosen BR. Non-invasive neurochemical analysis of focal excitotoxic lesions in models of neurodegenerative illness using spectroscopic imaging. J Cereb Blood Flow Metab. 1996 May; 16(3):450-61. PMID: 8621749.
    Citations: 13     Fields:    Translation:Animals
  89. Kirschner PB, Jenkins BG, Schulz JB, Finkelstein SP, Matthews RT, Rosen BR, Beal MF. NGF, BDNF and NT-5, but not NT-3 protect against MPP+ toxicity and oxidative stress in neonatal animals. Brain Res. 1996 Mar 25; 713(1-2):178-85. PMID: 8724989.
    Citations: 21     Fields:    Translation:HumansAnimals
  90. Schulz JB, Matthews RT, Jenkins BG, Ferrante RJ, Siwek D, Henshaw DR, Cipolloni PB, Mecocci P, Kowall NW, Rosen BR, et al. Blockade of neuronal nitric oxide synthase protects against excitotoxicity in vivo. J Neurosci. 1995 Dec; 15(12):8419-29. PMID: 8613773; PMCID: PMC6577929.
    Citations: 55     Fields:    Translation:AnimalsCells
  91. Guimaraes AR, Schwartz P, Prakash MR, Carr CA, Berger UV, Jenkins BG, Coyle JT, González RG. Quantitative in vivo 1H nuclear magnetic resonance spectroscopic imaging of neuronal loss in rat brain. Neuroscience. 1995 Dec; 69(4):1095-1101. PMID: 8848098.
    Citations: 12     Fields:    Translation:Animals
  92. Schulz JB, Matthews RT, Jenkins BG, Brar P, Beal MF. Improved therapeutic window for treatment of histotoxic hypoxia with a free radical spin trap. J Cereb Blood Flow Metab. 1995 Nov; 15(6):948-52. PMID: 7593355.
    Citations: 6     Fields:    Translation:Animals
  93. Hill RA, Chiappa KH, Huang-Hellinger F, Jenkins BG. EEG during MR imaging: differentiation of movement artifact from paroxysmal cortical activity. Neurology. 1995 Oct; 45(10):1942-3. PMID: 7478002.
    Citations: 4     Fields:    Translation:Humans
  94. Schulz JB, Henshaw DR, Siwek D, Jenkins BG, Ferrante RJ, Cipolloni PB, Kowall NW, Rosen BR, Beal MF. Involvement of free radicals in excitotoxicity in vivo. J Neurochem. 1995 May; 64(5):2239-47. PMID: 7536809.
    Citations: 47     Fields:    Translation:AnimalsCells
  95. Persichetti F, Ambrose CM, Ge P, McNeil SM, Srinidhi J, Anderson MA, Jenkins B, Barnes GT, Duyao MP, Kanaley L, et al. Normal and expanded Huntington's disease gene alleles produce distinguishable proteins due to translation across the CAG repeat. Mol Med. 1995 May; 1(4):374-83. PMID: 8521295; PMCID: PMC2230005.
    Citations: 25     Fields:    Translation:HumansCells
  96. Burns LH, Pakzaban P, Deacon TW, Brownell AL, Tatter SB, Jenkins BG, Isacson O. Selective putaminal excitotoxic lesions in non-human primates model the movement disorder of Huntington disease. Neuroscience. 1995 Feb; 64(4):1007-17. PMID: 7753372.
    Citations: 20     Fields:    Translation:Animals
  97. Beal MF, Henshaw DR, Jenkins BG, Rosen BR, Schulz JB. Coenzyme Q10 and nicotinamide block striatal lesions produced by the mitochondrial toxin malonate. Ann Neurol. 1994 Dec; 36(6):882-8. PMID: 7998775.
    Citations: 42     Fields:    Translation:AnimalsCells
  98. Schulz JB, Henshaw DR, Jenkins BG, Ferrante RJ, Kowall NW, Rosen BR, Beal MF. 3-Acetylpyridine produces age-dependent excitotoxic lesions in rat striatum. J Cereb Blood Flow Metab. 1994 Nov; 14(6):1024-9. PMID: 7929644.
    Citations: 3     Fields:    Translation:Animals
  99. Brouillet E, Hyman BT, Jenkins BG, Henshaw DR, Schulz JB, Sodhi P, Rosen BR, Beal MF. Systemic or local administration of azide produces striatal lesions by an energy impairment-induced excitotoxic mechanism. Exp Neurol. 1994 Oct; 129(2):175-82. PMID: 7525331.
    Citations: 4     Fields:    Translation:AnimalsCells
  100. Henshaw R, Jenkins BG, Schulz JB, Ferrante RJ, Kowall NW, Rosen BR, Beal MF. Malonate produces striatal lesions by indirect NMDA receptor activation. Brain Res. 1994 May 30; 647(1):161-6. PMID: 8069700.
    Citations: 16     Fields:    Translation:AnimalsCells
  101. Garrido L, Pfleiderer B, Jenkins BG, Hulka CA, Kopans DB. Migration and chemical modification of silicone in women with breast prostheses. Magn Reson Med. 1994 Mar; 31(3):328-30. PMID: 8057806.
    Citations: 9     Fields:    Translation:Humans
  102. Jenkins BG, Koroshetz WJ, Beal MF, Rosen BR. Evidence for impairment of energy metabolism in vivo in Huntington's disease using localized 1H NMR spectroscopy. Neurology. 1993 Dec; 43(12):2689-95. PMID: 8255479.
    Citations: 130     Fields:    Translation:Humans
  103. Beal MF, Brouillet E, Jenkins BG, Ferrante RJ, Kowall NW, Miller JM, Storey E, Srivastava R, Rosen BR, Hyman BT. Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid. J Neurosci. 1993 Oct; 13(10):4181-92. PMID: 7692009; PMCID: PMC6576392.
    Citations: 224     Fields:    Translation:AnimalsCells
  104. Beal MF, Brouillet E, Jenkins B, Henshaw R, Rosen B, Hyman BT. Age-dependent striatal excitotoxic lesions produced by the endogenous mitochondrial inhibitor malonate. J Neurochem. 1993 Sep; 61(3):1147-50. PMID: 7689641.
    Citations: 66     Fields:    Translation:AnimalsCells
  105. Brouillet E, Jenkins BG, Hyman BT, Ferrante RJ, Kowall NW, Srivastava R, Roy DS, Rosen BR, Beal MF. Age-dependent vulnerability of the striatum to the mitochondrial toxin 3-nitropropionic acid. J Neurochem. 1993 Jan; 60(1):356-9. PMID: 8417157.
    Citations: 67     Fields:    Translation:Cells
  106. Storey E, Hyman BT, Jenkins B, Brouillet E, Miller JM, Rosen BR, Beal MF. 1-Methyl-4-phenylpyridinium produces excitotoxic lesions in rat striatum as a result of impairment of oxidative metabolism. J Neurochem. 1992 May; 58(5):1975-8. PMID: 1560246.
    Citations: 17     Fields:    Translation:AnimalsCells
  107. Jenkins BG, Armstrong E, Lauffer RB. Site-specific water proton relaxation enhancement of iron(III) chelates noncovalently bound to human serum albumin. Magn Reson Med. 1991 Jan; 17(1):164-78. PMID: 1648652.
    Citations: 8     Fields:    Translation:HumansCells
  108. Jenkins BG. Detection of site-specific binding and co-binding of ligands to macromolecules using 19F NMR. Life Sci. 1991; 48(13):1227-40. PMID: 2002752.
    Citations: 7     Fields:    Translation:Cells
  109. Jenkins BG, Lauffer RB. Detection of site-specific binding and co-binding of ligands to human serum albumin using 19F NMR. Mol Pharmacol. 1990 Jan; 37(1):111-8. PMID: 2300044.
    Citations: 5     Fields:    Translation:HumansCells
  110. Larsen SK Jenkins BG Memon N Lauffer RB. Structure affinity relationships in the binding of unsubstituted iron phenolate complexes to human serum albumin. molecular structure of iron (III) N,N'-Bis (2-hydroxybenzyl)ethylenediamine-N,N'diacetate. Inorganic Chemistry. 1990; 29:1147-1152.
  111. Jenkins BG Lauffer RB. Solution structure and dynamics of lanthanide(III) complexes of diethylenetriaminepentaacetate: a two-dimensional NMR analysis. Inorganic Chemistry. 1988; 27(26):4730-4738.
  112. Jenkins BG Lauffer RB. 2D NMR of paramagnetic complexes of diethylene triaminepentaacetate. Journal of Magnetic Resonance. 1988; 80:328-336.
  113. Jenkins BG, Wartell RM, Alderfer JL. Conformational properties of poly[d(G-T)].poly[d(C-A)] and poly[d(A-T)] in low- and high-salt solutions: NMR and laser Raman analysis. Biopolymers. 1986 May; 25(5):823-49. PMID: 3755066.
    Citations: 1     Fields:    Translation:Cells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.