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Marcello Pagano, Ph.D.

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Overview
Professor Pagano obtained a Ph.D. from Johns Hopkins University and has spent the last 35 years on the faculty at the Harvard School Public Health teaching biostatistics and advising students. His research in biostatistics continues to be on compute intensive inference and surveillance methods that involve screening methodologies, with their associated laboratory tests, and in obtaining more accurate testing results that use existing technologies. The accuracy of these screening tests is important-for example to maintain the integrity of the nation's blood supply-and it is doubly beneficial if these methods are also cheaper to implement; thus more testing can be done. This can mean a safer blood supply, for example.

His interests extend to the quantitative aspects of Monitoring and Evaluation, especially as they are applied in resource poor settings, and are brought to bear to improve the quality of health services to all.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. T36GM093773 (PAGANO, MARCELLO) Sep 1, 2013 - Dec 31, 2018
    NIH
    Pipelines into Biostatistics: Training in Quantitative Public Health
    Role: Co-Principal Investigator
  2. R01AI097015 (PAGANO, MARCELLO) Mar 1, 2012 - Feb 28, 2018
    NIH
    Accurate and Efficient Measures for HIV Incidence
    Role: Principal Investigator
  3. R56EB006195 (PAGANO, MARCELLO) Sep 20, 2005 - Jan 31, 2012
    NIH
    Statistical Model of the AIDS Epidemic
    Role: Principal Investigator
  4. R01EB006195 (PAGANO, MARCELLO) Sep 20, 2005 - Aug 9, 2009
    NIH
    Statistical Model of the AIDS Epidemic
    Role: Principal Investigator
  5. R01AI028076 (PAGANO, MARCELLO) Sep 30, 1989 - Sep 19, 2005
    NIH
    Statistical Model of the AIDS Epidemic
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Ocampo A, Schmidli H, Quarg P, Callegari F, Pagano M. Identifying treatment effects using trimmed means when data are missing not at random. Pharm Stat. 2021 Jun 24. PMID: 34169641.
    Citations:    Fields:    
  2. White LF, Moser CB, Thompson RN, Pagano M. Statistical Estimation of the Reproductive Number From Case Notification Data. Am J Epidemiol. 2021 04 06; 190(4):611-620. PMID: 33034345.
    Citations: 3     Fields:    Translation:HumansPHPublic Health
  3. Litvak E, Dentzer S, Pagano M. The Right Kind of Pooled Testing for the Novel Coronavirus: First, Do No Harm. Am J Public Health. 2020 12; 110(12):1772-1773. PMID: 32970452.
    Citations: 1     Fields:    Translation:HumansPHPublic Health
  4. Jeffery C, Pagano M, Hemingway J, Valadez JJ. Hybrid prevalence estimation: Method to improve intervention coverage estimations. Proc Natl Acad Sci U S A. 2018 12 18; 115(51):13063-13068. PMID: 30518561.
    Citations: 2     Fields:    Translation:HumansPHPublic Health
  5. Marino M, Pagano M. Role of survey response rates on valid inference: an application to HIV prevalence estimates. Emerg Themes Epidemiol. 2018; 15:6. PMID: 29527231.
    Citations: 1     
  6. Mitnick CD, White RA, Lu C, Rodriguez CA, Bayona J, Becerra MC, Burgos M, Centis R, Cohen T, Cox H, D'Ambrosio L, Danilovitz M, Falzon D, Gelmanova IY, Gler MT, Grinsdale JA, Holtz TH, Keshavjee S, Leimane V, Menzies D, Migliori GB, Milstein MB, Mishustin SP, Pagano M, Quelapio MI, Shean K, Shin SS, Tolman AW, van der Walt ML, Van Deun A, Viiklepp P. Multidrug-resistant tuberculosis treatment failure detection depends on monitoring interval and microbiological method. Eur Respir J. 2016 10; 48(4):1160-1170. PMID: 27587552.
    Citations: 10     Fields:    Translation:HumansCells
  7. Milstein M, Lecca L, Peloquin C, Mitchison D, Seung K, Pagano M, Coleman D, Osso E, Coit J, Vargas Vasquez DE, Sanchez Garavito E, Calderon R, Contreras C, Davies G, Mitnick CD. Evaluation of high-dose rifampin in patients with new, smear-positive tuberculosis (HIRIF): study protocol for a randomized controlled trial. BMC Infect Dis. 2016 08 27; 16(1):453. PMID: 27567500.
    Citations: 11     Fields:    Translation:Humans
  8. Anoke SC, Mwai P, Jeffery C, Valadez JJ, Pagano M. Comparing two survey methods of measuring health-related indicators: Lot Quality Assurance Sampling and Demographic Health Surveys. Trop Med Int Health. 2015 Dec; 20(12):1756-70. PMID: 26425920.
    Citations: 8     Fields:    Translation:Humans
  9. Patterson-Lomba O, Wu JW, Pagano M. Assessing Biases in the Evaluation of Classification Assays for HIV Infection Recency. PLoS One. 2015; 10(10):e0139735. PMID: 26436915.
    Citations: 1     Fields:    Translation:HumansCells
  10. Wu JW, Patterson-Lomba O, Novitsky V, Pagano M. A Generalized Entropy Measure of Within-Host Viral Diversity for Identifying Recent HIV-1 Infections. Medicine (Baltimore). 2015 Oct; 94(42):e1865. PMID: 26496342.
    Citations: 5     Fields:    Translation:HumansCells
  11. Mphaphlele M, Dharmadhikari AS, Jensen PA, Rudnick SN, van Reenen TH, Pagano MA, Leuschner W, Sears TA, Milonova SP, van der Walt M, Stoltz AC, Weyer K, Nardell EA. Institutional Tuberculosis Transmission. Controlled Trial of Upper Room Ultraviolet Air Disinfection: A Basis for New Dosing Guidelines. Am J Respir Crit Care Med. 2015 Aug 15; 192(4):477-84. PMID: 25928547.
    Citations: 16     Fields:    Translation:AnimalsPHPublic Health
  12. Ackermann N, Goodman MS, Gilbert K, Arroyo-Johnson C, Pagano M. Race, law, and health: Examination of 'Stand Your Ground' and defendant convictions in Florida. Soc Sci Med. 2015 Oct; 142:194-201. PMID: 26313247.
    Citations: 2     Fields:    Translation:Humans
  13. Hund L, Bedrick EJ, Pagano M. Choosing a Cluster Sampling Design for Lot Quality Assurance Sampling Surveys. PLoS One. 2015; 10(6):e0129564. PMID: 26125967.
    Citations: 3     Fields:    Translation:Humans
  14. Jenkins HE, Pagano M, Yuen CM, Becerra MC, Cohen T. The burden of tuberculosis disease in children--Authors' reply. Lancet. 2014 Oct 11; 384(9951):1343-4. PMID: 25307837.
    Citations: 3     Fields:    Translation:Humans
  15. Jenkins HE, Tolman AW, Yuen CM, Parr JB, Keshavjee S, Pérez-Vélez CM, Pagano M, Becerra MC, Cohen T. Incidence of multidrug-resistant tuberculosis disease in children: systematic review and global estimates. Lancet. 2014 May 03; 383(9928):1572-9. PMID: 24671080.
    Citations: 81     Fields:    Translation:Humans
  16. White LF, Archer B, Pagano M. Determining the dynamics of influenza transmission by age. Emerg Themes Epidemiol. 2014 Mar 21; 11(1):4. PMID: 24656239.
    Citations: 9     
  17. Hund L, Pagano M. Extending cluster lot quality assurance sampling designs for surveillance programs. Stat Med. 2014 Jul 20; 33(16):2746-57. PMID: 24633656.
    Citations: 3     Fields:    Translation:HumansPHPublic Health
  18. Jeffery C, Ozonoff A, Pagano M. The effect of spatial aggregation on performance when mapping a risk of disease. Int J Health Geogr. 2014 Mar 13; 13:9. PMID: 24625068.
    Citations: 3     Fields:    Translation:HumansPHPublic Health
  19. Olives C, Valadez JJ, Pagano M. Estimation after classification using lot quality assurance sampling: corrections for curtailed sampling with application to evaluating polio vaccination campaigns. Trop Med Int Health. 2014 Mar; 19(3):321-330. PMID: 24382319.
    Citations: 1     Fields:    Translation:HumansPHPublic Health
  20. Hund L, Northrop-Clewes CA, Nazario R, Suleymanova D, Mirzoyan L, Irisova M, Pagano M, Valadez JJ. A novel approach to evaluating the iron and folate status of women of reproductive age in Uzbekistan after 3 years of flour fortification with micronutrients. PLoS One. 2013; 8(11):e79726. PMID: 24260293.
    Citations: 8     Fields:    Translation:Humans
  21. Hedt-Gauthier BL, Mitsunaga T, Hund L, Olives C, Pagano M. The effect of clustering on lot quality assurance sampling: a probabilistic model to calculate sample sizes for quality assessments. Emerg Themes Epidemiol. 2013 Oct 26; 10(1):11. PMID: 24160725.
    Citations: 6     
  22. White LF, Archer B, Pagano M. Estimating the reproductive number in the presence of spatial heterogeneity of transmission patterns. Int J Health Geogr. 2013 Jul 26; 12:35. PMID: 23890514.
    Citations: 5     Fields:    Translation:HumansPHPublic Health
  23. White RA, Bjørnholt JV, Baird DD, Midtvedt T, Harris JR, Pagano M, Hide W, Rudi K, Moen B, Iszatt N, Peddada SD, Eggesbø M. Novel developmental analyses identify longitudinal patterns of early gut microbiota that affect infant growth. PLoS Comput Biol. 2013; 9(5):e1003042. PMID: 23671411.
    Citations: 36     Fields:    Translation:HumansCells
  24. Jeffery C, Ozonoff A, White LF, Pagano M. Distance-based mapping of disease risk. Int J Biostat. 2013 May 07; 9(2):265-90. PMID: 23658215.
    Citations: 2     Fields:    Translation:HumansPHPublic Health
  25. Hund L, Pagano M. Estimating HIV prevalence from surveys with low individual consent rates: annealing individual and pooled samples. Emerg Themes Epidemiol. 2013 Feb 27; 10(1):2. PMID: 23446064.
    Citations: 6     
  26. Finucane MM, Rowley CF, Paciorek CJ, Essex M, Pagano M. Estimating the prevalence of transmitted HIV drug resistance using pooled samples. Stat Methods Med Res. 2016 04; 25(2):917-35. PMID: 23376965.
    Citations: 1     Fields:    Translation:HumansCells
  27. Olives C, Pagano M. Choosing a design to fit the situation: how to improve specificity and positive predictive values using Bayesian lot quality assurance sampling. Int J Epidemiol. 2013 Feb; 42(1):346-55. PMID: 23378151.
    Citations: 4     Fields:    Translation:HumansPHPublic Health
  28. Archer BN, Tempia S, White LF, Pagano M, Cohen C. Reproductive number and serial interval of the first wave of influenza A(H1N1)pdm09 virus in South Africa. PLoS One. 2012; 7(11):e49482. PMID: 23166682.
    Citations: 4     Fields:    Translation:HumansCellsPHPublic Health
  29. Mitchell SA, Pagano M. Effective classification of the prevalence of Schistosoma mansoni. Trop Med Int Health. 2012 Dec; 17(12):1470-7. PMID: 23107575.
    Citations: 1     Fields:    Translation:HumansAnimalsPHPublic Health
  30. Hirschhorn LR, Pagano M. Estimating the benefits of antiretroviral therapy programs: how certain can we get? J Infect Dis. 2013 Jan 01; 207(1):4-5. PMID: 23100565.
    Citations: 1     Fields:    Translation:HumansCells
  31. Fier H, Won S, Prokopenko D, AlChawa T, Ludwig KU, Fimmers R, Silverman EK, Pagano M, Mangold E, Lange C. 'Location, Location, Location': a spatial approach for rare variant analysis and an application to a study on non-syndromic cleft lip with or without cleft palate. Bioinformatics. 2012 Dec 01; 28(23):3027-33. PMID: 23044548.
    Citations: 8     Fields:    Translation:HumansCells
  32. Mitchell S, Pagano M. Pooled testing for effective estimation of the prevalence of Schistosoma mansoni. Am J Trop Med Hyg. 2012 Nov; 87(5):850-861. PMID: 22964721.
    Citations: 8     Fields:    Translation:Animals
  33. Olives C, Valadez JJ, Brooker SJ, Pagano M. Multiple category-lot quality assurance sampling: a new classification system with application to schistosomiasis control. PLoS Negl Trop Dis. 2012; 6(9):e1806. PMID: 22970333.
    Citations: 12     Fields:    Translation:HumansAnimals
  34. Hedt-Gauthier BL, Tenthani L, Mitchell S, Chimbwandira FM, Makombe S, Chirwa Z, Schouten EJ, Pagano M, Jahn A. Improving data quality and supervision of antiretroviral therapy sites in Malawi: an application of Lot Quality Assurance Sampling. BMC Health Serv Res. 2012 Jul 09; 12:196. PMID: 22776745.
    Citations: 5     Fields:    Translation:Humans
  35. Cohen T, Lin HH, Shin S, Jeffery C, Contreras C, Cruz JS, Jave O, Yagui M, Asencios L, Pagano M, Manjourides J. Re: Supporting health systems for tuberculosis through research. Tuberculosis (Edinb). 2012 Jul; 92(4):290. PMID: 22687425.
    Citations:    
  36. Manjourides J, Lin HH, Shin S, Jeffery C, Contreras C, Cruz JS, Jave O, Yagui M, Asencios L, Pagano M, Cohen T. Identifying multidrug resistant tuberculosis transmission hotspots using routinely collected data. Tuberculosis (Edinb). 2012 May; 92(3):273-9. PMID: 22401962.
    Citations: 12     Fields:    Translation:HumansCellsPHPublic Health
  37. Dharmadhikari AS, Mphahlele M, Stoltz A, Venter K, Mathebula R, Masotla T, Lubbe W, Pagano M, First M, Jensen PA, van der Walt M, Nardell EA. Surgical face masks worn by patients with multidrug-resistant tuberculosis: impact on infectivity of air on a hospital ward. Am J Respir Crit Care Med. 2012 May 15; 185(10):1104-9. PMID: 22323300.
    Citations: 39     Fields:    Translation:HumansAnimalsPHPublic Health
  38. Manjourides J, Pagano M. Improving the power of chronic disease surveillance by incorporating residential history. Stat Med. 2011 Aug 15; 30(18):2222-33. PMID: 21563208.
    Citations: 7     Fields:    Translation:HumansPHPublic Health
  39. Hedt BL, Pagano M. Health indicators: eliminating bias from convenience sampling estimators. Stat Med. 2011 Feb 28; 30(5):560-8. PMID: 21290401.
    Citations: 21     Fields:    Translation:HumansPHPublic Health
  40. White LF, Pagano M. Reporting errors in infectious disease outbreaks, with an application to Pandemic Influenza A/H1N1. Epidemiol Perspect Innov. 2010 Dec 15; 7:12. PMID: 21159178.
    Citations: 12     
  41. Cohen T, Hedt BL, Pagano M. Estimating the magnitude and direction of bias in tuberculosis drug resistance surveys conducted only in the public sector: a simulation study. BMC Public Health. 2010 Jun 21; 10:355. PMID: 20565947.
    Citations: 5     Fields:    Translation:Humans
  42. Olives C, Pagano M. Bayes-LQAS: classifying the prevalence of global acute malnutrition. Emerg Themes Epidemiol. 2010 Jun 09; 7(1):3. PMID: 20534159.
    Citations: 10     
  43. Biedron C, Pagano M, Hedt BL, Kilian A, Ratcliffe A, Mabunda S, Valadez JJ. An assessment of Lot Quality Assurance Sampling to evaluate malaria outcome indicators: extending malaria indicator surveys. Int J Epidemiol. 2010 Feb; 39(1):72-9. PMID: 20139435.
    Citations: 24     Fields:    Translation:HumansPHPublic Health
  44. Pagano M, Valadez JJ. Commentary: Understanding practical lot quality assurance sampling. Int J Epidemiol. 2010 Feb; 39(1):69-71. PMID: 20139434.
    Citations: 17     Fields:    Translation:Humans
  45. Edillo F, Kiszewski A, Manjourides J, Pagano M, Hutchinson M, Kyle A, Arias J, Gaines D, Lampman R, Novak R, Foppa I, Lubelcyzk C, Smith R, Moncayo A, Spielman A. Effects of latitude and longitude on the population structure of Culex pipiens s.l., vectors of West Nile virus in North America. Am J Trop Med Hyg. 2009 Nov; 81(5):842-8. PMID: 19861620.
    Citations: 11     Fields:    Translation:AnimalsCells
  46. White LF, Wallinga J, Finelli L, Reed C, Riley S, Lipsitch M, Pagano M. Estimation of the reproductive number and the serial interval in early phase of the 2009 influenza A/H1N1 pandemic in the USA. Influenza Other Respir Viruses. 2009 Nov; 3(6):267-76. PMID: 19903209.
    Citations: 94     Fields:    Translation:HumansCellsPHPublic Health
  47. Jeffery C, Ozonoff A, White LF, Nuño M, Pagano M. Power to detect spatial disturbances under different levels of geographic aggregation. J Am Med Inform Assoc. 2009 Nov-Dec; 16(6):847-54. PMID: 19717807.
    Citations: 7     Fields:    Translation:HumansPHPublic Health
  48. White LF, Bonetti M, Pagano M. The Choice of the Number of Bins for the M Statistic. Comput Stat Data Anal. 2009 Aug 01; 53(10):3640-3649. PMID: 20161224.
    Citations: 2     
  49. Olives C, Pagano M, Deitchler M, Hedt BL, Egge K, Valadez JJ. Cluster designs to assess the prevalence of acute malnutrition by lot quality assurance sampling: a validation study by computer simulation. J R Stat Soc Ser A Stat Soc. 2009 04; 172(2):495-510. PMID: 20011037.
    Citations: 5     
  50. Kuban KC, Allred EN, O'Shea TM, Paneth N, Pagano M, Dammann O, Leviton A, Du Plessis A, Westra SJ, Miller CR, Bassan H, Krishnamoorthy K, Junewick J, Olomu N, Romano E, Seibert J, Engelke S, Karna P, Batton D, O'Connor SE, Keller CE. Cranial ultrasound lesions in the NICU predict cerebral palsy at age 2 years in children born at extremely low gestational age. J Child Neurol. 2009 Jan; 24(1):63-72. PMID: 19168819.
    Citations: 47     Fields:    Translation:Humans
  51. O'Shea TM, Kuban KC, Allred EN, Paneth N, Pagano M, Dammann O, Bostic L, Brooklier K, Butler S, Goldstein DJ, Hounshell G, Keller C, McQuiston S, Miller A, Pasternak S, Plesha-Troyke S, Price J, Romano E, Solomon KM, Jacobson A, Westra S, Leviton A. Neonatal cranial ultrasound lesions and developmental delays at 2 years of age among extremely low gestational age children. Pediatrics. 2008 Sep; 122(3):e662-9. PMID: 18762501.
    Citations: 49     Fields:    Translation:Humans
  52. Kuban KC, Allred EN, O'Shea M, Paneth N, Pagano M, Leviton A. An algorithm for identifying and classifying cerebral palsy in young children. J Pediatr. 2008 Oct; 153(4):466-72. PMID: 18534210.
    Citations: 39     Fields:    Translation:Humans
  53. White LF, Pagano M. Transmissibility of the influenza virus in the 1918 pandemic. PLoS One. 2008 Jan 30; 3(1):e1498. PMID: 18231585.
    Citations: 27     Fields:    Translation:HumansCellsPHPublic Health
  54. Ozonoff A, Jeffery C, Manjourides J, White LF, Pagano M. Effect of spatial resolution on cluster detection: a simulation study. Int J Health Geogr. 2007 Nov 27; 6:52. PMID: 18042281.
    Citations: 32     Fields:    Translation:HumansPHPublic Health
  55. Healy B, De Gruttola V, Pagano M. Combining cross-sectional and prospective data methods to improve transition parameter estimation for characterizing the accumulation of HIV-1 drug resistance mutations. Biometrics. 2007 Sep; 63(3):742-50. PMID: 17403101.
    Citations:    Fields:    Translation:Cells
  56. Olson KL, Bonetti M, Pagano M, Mandl KD. Real time spatial cluster detection using interpoint distances among precise patient locations. BMC Med Inform Decis Mak. 2005 Jun 21; 5:19. PMID: 15969749.
    Citations: 7     Fields:    Translation:HumansPHPublic Health
  57. Bonetti M, Pagano M. The interpoint distance distribution as a descriptor of point patterns, with an application to spatial disease clustering. Stat Med. 2005 Mar 15; 24(5):753-73. PMID: 15523703.
    Citations: 19     Fields:    Translation:HumansPHPublic Health
  58. Pagano M. Surveys: are they trustworthy? Nutrition. 2004 Oct; 20(10):948. PMID: 15474887.
    Citations:    Fields:    Translation:Humans
  59. Ozonoff A, Forsberg L, Bonetti M, Pagano M. Bivariate method for spatio-temporal syndromic surveillance. MMWR Suppl. 2004 Sep 24; 53:59-66. PMID: 15714631.
    Citations: 6     Translation:HumansPHPublic Health
  60. McManus ML, Long MC, Cooper A, Mandell J, Berwick DM, Pagano M, Litvak E. Variability in surgical caseload and access to intensive care services. Anesthesiology. 2003 Jun; 98(6):1491-6. PMID: 12766663.
    Citations: 24     Fields:    
  61. Reis BY, Pagano M, Mandl KD. Using temporal context to improve biosurveillance. Proc Natl Acad Sci U S A. 2003 Feb 18; 100(4):1961-5. PMID: 12574522.
    Citations: 41     Fields:    Translation:HumansPHPublic Health
  62. Caruso RA, Bellocco R, Pagano M, Bertoli G, Rigoli L, Inferrera C. Prognostic value of intratumoral neutrophils in advanced gastric carcinoma in a high-risk area in northern Italy. Mod Pathol. 2002 Aug; 15(8):831-7. PMID: 12181268.
    Citations: 68     Fields:    Translation:HumansCells
  63. Dammann O, Allred EN, Kuban KC, Van Marter LJ, Pagano M, Sanocka U, Leviton A. Systemic hypotension and white-matter damage in preterm infants. Dev Med Child Neurol. 2002 Feb; 44(2):82-90. PMID: 11852927.
    Citations: 14     Fields:    Translation:Humans
  64. Van Marter LJ, Dammann O, Allred EN, Leviton A, Pagano M, Moore M, Martin C. Chorioamnionitis, mechanical ventilation, and postnatal sepsis as modulators of chronic lung disease in preterm infants. J Pediatr. 2002 Feb; 140(2):171-6. PMID: 11865267.
    Citations: 76     Fields:    Translation:HumansCells
  65. Stewart JE, Allred EN, Collins M, Abbott J, Leviton A, Paneth N, Reuss ML, Susser M, Hegyi T, Hiatt M, Sanocka U, Shahrivar F, Van Marter LJ, Banogan P, Genest D, Heller D, Shen-Schwarz S, Dammann O, Kuban KC, Pagano M. Risk of cranial ultrasound abnormalities in very-low-birth-weight infants conceived with assisted reproductive techniques. J Perinatol. 2002 Jan; 22(1):37-45. PMID: 11840241.
    Citations: 3     Fields:    Translation:Humans
  66. Leviton A, Pagano M, Kuban KCK, Fenton T, Wolff M, Strassfeld R. Preterm infants born to women who had an elevated prepregnancy body mass index appear to be at increased risk of germinal matrix hemorrhage. Am J Hum Biol. 1992; 4(5):567-572. PMID: 28524596.
    Citations:    Fields:    
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.