Harvard Catalyst Profiles

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Eduardo Folco, Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Molinaro R, Yu M, Sausen G, Bichsel CA, Corbo C, Folco EJ, Lee GY, Liu Y, Tesmenitsky Y, Shvartz E, Sukhova GK, Kloss F, Croce KJ, Farokhzad OC, Shi J, Libby P. Targeted delivery of Protein Arginine Deiminase-4 inhibitors to limit arterial intimal NETosis and preserve endothelial integrity. Cardiovasc Res. 2021 Mar 05. PMID: 33751034.
    Citations:    Fields:    
  2. Schumski A, Ortega-Gómez A, Wichapong K, Winter C, Lemnitzer P, Viola JR, Pinilla-Vera M, Folco E, Solis-Mezarino V, Völker-Albert M, Maas SL, Pan C, Perez Olivares L, Winter J, Hackeng T, Karlsson MCI, Zeller T, Imhof A, Baron RM, Nicolaes GAF, Libby P, Maegdefessel L, Kamp F, Benoit M, Döring Y, Soehnlein O. Endotoxinemia Accelerates Atherosclerosis Through Electrostatic Charge-Mediated Monocyte Adhesion. Circulation. 2021 Jan 19; 143(3):254-266. PMID: 33167684.
    Citations: 2     Fields:    
  3. Marchini JF, Manica A, Crestani P, Dutzmann J, Folco EJ, Weber H, Libby P, Croce K. Oxidized Low-Density Lipoprotein Induces Macrophage Production of Prothrombotic Microparticles. J Am Heart Assoc. 2020 08 04; 9(15):e015878. PMID: 32750308.
    Citations: 1     Fields:    Translation:HumansCells
  4. Vromman A, Ruvkun V, Shvartz E, Wojtkiewicz G, Santos Masson G, Tesmenitsky Y, Folco E, Gram H, Nahrendorf M, Swirski FK, Sukhova GK, Libby P. Stage-dependent differential effects of interleukin-1 isoforms on experimental atherosclerosis. Eur Heart J. 2019 08 07; 40(30):2482-2491. PMID: 30698710.
    Citations: 13     Fields:    Translation:AnimalsCells
  5. Folco EJ, Mawson TL, Vromman A, Bernardes-Souza B, Franck G, Persson O, Nakamura M, Newton G, Luscinskas FW, Libby P. Neutrophil Extracellular Traps Induce Endothelial Cell Activation and Tissue Factor Production Through Interleukin-1a and Cathepsin G. Arterioscler Thromb Vasc Biol. 2018 08; 38(8):1901-1912. PMID: 29976772.
    Citations: 47     Fields:    Translation:HumansCells
  6. Franck G, Mawson TL, Folco EJ, Molinaro R, Ruvkun V, Engelbertsen D, Liu X, Tesmenitsky Y, Shvartz E, Sukhova GK, Michel JB, Nicoletti A, Lichtman A, Wagner D, Croce KJ, Libby P. Roles of PAD4 and NETosis in Experimental Atherosclerosis and Arterial Injury: Implications for Superficial Erosion. Circ Res. 2018 06 22; 123(1):33-42. PMID: 29572206.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  7. Quillard T, Franck G, Mawson T, Folco E, Libby P. Mechanisms of erosion of atherosclerotic plaques. Curr Opin Lipidol. 2017 Oct; 28(5):434-441. PMID: 28682809.
    Citations: 25     Fields:    Translation:HumansAnimals
  8. Beltrami-Moreira M, Vromman A, Sukhova GK, Folco EJ, Libby P. Redundancy of IL-1 Isoform Signaling and Its Implications for Arterial Remodeling. PLoS One. 2016; 11(3):e0152474. PMID: 27032103.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  9. Folco EJ, Sukhova GK, Quillard T, Libby P. Moderate hypoxia potentiates interleukin-1ß production in activated human macrophages. Circ Res. 2014 Oct 24; 115(10):875-83. PMID: 25185259.
    Citations: 42     Fields:    Translation:HumansCells
  10. Taqueti VR, Di Carli MF, Jerosch-Herold M, Sukhova GK, Murthy VL, Folco EJ, Kwong RY, Ozaki CK, Belkin M, Nahrendorf M, Weissleder R, Libby P. Increased microvascularization and vessel permeability associate with active inflammation in human atheromata. Circ Cardiovasc Imaging. 2014 Nov; 7(6):920-9. PMID: 25170063.
    Citations: 22     Fields:    Translation:HumansCells
  11. Rocha VZ, Folco EJ, Ozdemir C, Sheikine Y, Christen T, Sukhova GK, Tang EH, Bittencourt MS, Santos RD, Luster AD, Cohen DE, Libby P. CXCR3 controls T-cell accumulation in fat inflammation. Arterioscler Thromb Vasc Biol. 2014 Jul; 34(7):1374-81. PMID: 24812325.
    Citations: 15     Fields:    Translation:AnimalsCells
  12. Cheng X, Wang J, Xia N, Yan XX, Tang TT, Chen H, Zhang HJ, Liu J, Kong W, Sjöberg S, Folco E, Libby P, Liao YH, Shi GP. A guanidine-rich regulatory oligodeoxynucleotide improves type-2 diabetes in obese mice by blocking T-cell differentiation. EMBO Mol Med. 2012 Oct; 4(10):1112-25. PMID: 23027613.
    Citations: 5     Fields:    Translation:AnimalsCells
  13. Cheng X, Folco EJ, Shimizu K, Libby P. Adiponectin induces pro-inflammatory programs in human macrophages and CD4+ T cells. J Biol Chem. 2012 Oct 26; 287(44):36896-904. PMID: 22948153.
    Citations: 37     Fields:    Translation:HumansCells
  14. Shimizu K, Libby P, Rocha VZ, Folco EJ, Shubiki R, Grabie N, Jang S, Lichtman AH, Shimizu A, Hogg N, Simon DI, Mitchell RN, Croce K. Loss of myeloid related protein-8/14 exacerbates cardiac allograft rejection. Circulation. 2011 Dec 20; 124(25):2920-32. PMID: 22144572.
    Citations: 13     Fields:    Translation:AnimalsCells
  15. Libby P, Folco E. Tension in the plaque: hypoxia modulates metabolism in atheroma. Circ Res. 2011 Oct 28; 109(10):1100-2. PMID: 22034477.
    Citations: 6     Fields:    Translation:HumansAnimals
  16. Rocha VZ, Folco EJ. Inflammatory concepts of obesity. Int J Inflam. 2011; 2011:529061. PMID: 21837268.
    Citations: 36     
  17. Folco EJ, Sheikine Y, Rocha VZ, Christen T, Shvartz E, Sukhova GK, Di Carli MF, Libby P. Hypoxia but not inflammation augments glucose uptake in human macrophages: Implications for imaging atherosclerosis with 18fluorine-labeled 2-deoxy-D-glucose positron emission tomography. J Am Coll Cardiol. 2011 Aug 02; 58(6):603-14. PMID: 21798423.
    Citations: 113     Fields:    Translation:HumansCells
  18. Vinegoni C, Botnaru I, Aikawa E, Calfon MA, Iwamoto Y, Folco EJ, Ntziachristos V, Weissleder R, Libby P, Jaffer FA. Indocyanine green enables near-infrared fluorescence imaging of lipid-rich, inflamed atherosclerotic plaques. Sci Transl Med. 2011 May 25; 3(84):84ra45. PMID: 21613624.
    Citations: 70     Fields:    Translation:HumansAnimalsCells
  19. Libby P, Okamoto Y, Rocha VZ, Folco E. Inflammation in atherosclerosis: transition from theory to practice. Circ J. 2010 Feb; 74(2):213-20. PMID: 20065609.
    Citations: 200     Fields:    Translation:HumansAnimalsCells
  20. Folco EJ, Rocha VZ, López-Ilasaca M, Libby P. Adiponectin inhibits pro-inflammatory signaling in human macrophages independent of interleukin-10. J Biol Chem. 2009 Sep 18; 284(38):25569-75. PMID: 19617629.
    Citations: 55     Fields:    Translation:HumansCells
  21. Ovchinnikova O, Robertson AK, Wågsäter D, Folco EJ, Hyry M, Myllyharju J, Eriksson P, Libby P, Hansson GK. T-cell activation leads to reduced collagen maturation in atherosclerotic plaques of Apoe(-/-) mice. Am J Pathol. 2009 Feb; 174(2):693-700. PMID: 19131590.
    Citations: 20     Fields:    Translation:AnimalsCells
  22. Rocha VZ, Folco EJ, Sukhova G, Shimizu K, Gotsman I, Vernon AH, Libby P. Interferon-gamma, a Th1 cytokine, regulates fat inflammation: a role for adaptive immunity in obesity. Circ Res. 2008 Aug 29; 103(5):467-76. PMID: 18658050.
    Citations: 201     Fields:    Translation:AnimalsCells
  23. Brunner M, Peng X, Liu GX, Ren XQ, Ziv O, Choi BR, Mathur R, Hajjiri M, Odening KE, Steinberg E, Folco EJ, Pringa E, Centracchio J, Macharzina RR, Donahay T, Schofield L, Rana N, Kirk M, Mitchell GF, Poppas A, Zehender M, Koren G. Mechanisms of cardiac arrhythmias and sudden death in transgenic rabbits with long QT syndrome. J Clin Invest. 2008 Jun; 118(6):2246-59. PMID: 18464931.
    Citations: 82     Fields:    Translation:AnimalsCells
  24. Jindal HK, Folco EJ, Liu GX, Koren G. Posttranslational modification of voltage-dependent potassium channel Kv1.5: COOH-terminal palmitoylation modulates its biological properties. . 2008 May; 294(5):H2012-21. PMID: 18344374.
    Citations: 22     Translation:AnimalsCells
  25. Minami M, Shimizu K, Okamoto Y, Folco E, Ilasaca ML, Feinberg MW, Aikawa M, Libby P. Prostaglandin E receptor type 4-associated protein interacts directly with NF-kappaB1 and attenuates macrophage activation. J Biol Chem. 2008 Apr 11; 283(15):9692-703. PMID: 18270204.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  26. Isoda K, Folco E, Marwali MR, Ohsuzu F, Libby P. Glycated LDL increases monocyte CC chemokine receptor 2 expression and monocyte chemoattractant protein-1-mediated chemotaxis. Atherosclerosis. 2008 Jun; 198(2):307-12. PMID: 18164016.
    Citations: 15     Fields:    Translation:HumansCells
  27. Okamoto Y, Folco EJ, Minami M, Wara AK, Feinberg MW, Sukhova GK, Colvin RA, Kihara S, Funahashi T, Luster AD, Libby P. Adiponectin inhibits the production of CXC receptor 3 chemokine ligands in macrophages and reduces T-lymphocyte recruitment in atherogenesis. Circ Res. 2008 Feb 01; 102(2):218-25. PMID: 17991878.
    Citations: 79     Fields:    Translation:HumansCells
  28. Isoda K, Folco EJ, Shimizu K, Libby P. AGE-BSA decreases ABCG1 expression and reduces macrophage cholesterol efflux to HDL. Atherosclerosis. 2007 Jun; 192(2):298-304. PMID: 17005185.
    Citations: 17     Fields:    Translation:HumansCells
  29. Desplats P, Folco E, Salerno GL. Sucrose may play an additional role to that of an osmolyte in Synechocystis sp. PCC 6803 salt-shocked cells. . 2005 Feb; 43(2):133-8. PMID: 15820660.
    Citations: 21     Translation:Cells
  30. Folco EJ, Liu GX, Koren G. Caveolin-3 and SAP97 form a scaffolding protein complex that regulates the voltage-gated potassium channel Kv1.5. . 2004 Aug; 287(2):H681-90. PMID: 15277200.
    Citations: 25     Translation:AnimalsCells
  31. Folco EJ, Roder K, Mitchell GF, Koren G. "Cardiac memory": a struggle against forgetting. Circ Res. 2003 Sep 05; 93(5):384-6. PMID: 12958140.
    Citations:    Fields:    Translation:AnimalsCells
  32. Brunner M, Kodirov SA, Mitchell GF, Buckett PD, Shibata K, Folco EJ, Baker L, Salama G, Chan DP, Zhou J, Koren G. In vivo gene transfer of Kv1.5 normalizes action potential duration and shortens QT interval in mice with long QT phenotype. . 2003 Jul; 285(1):H194-203. PMID: 12793978.
    Citations: 14     Translation:AnimalsCells
  33. Murata M, Buckett PD, Zhou J, Brunner M, Folco E, Koren G. SAP97 interacts with Kv1.5 in heterologous expression systems. . 2001 Dec; 281(6):H2575-84. PMID: 11709425.
    Citations: 16     Translation:AnimalsCells
  34. Curatti L, Folco E, Desplats P, Abratti G, Limones V, Herrera-Estrella L, Salerno G. Sucrose-phosphate synthase from Synechocystis sp. strain PCC 6803: identification of the spsA gene and characterization of the enzyme expressed in Escherichia coli. J Bacteriol. 1998 Dec; 180(24):6776-9. PMID: 9852031.
    Citations: 20     Fields:    Translation:Cells
  35. Folco EJ, Koren G. Degradation of the inducible cAMP early repressor (ICER) by the ubiquitin-proteasome pathway. Biochem J. 1997 Nov 15; 328 ( Pt 1):37-43. PMID: 9359831.
    Citations: 14     Fields:    Translation:AnimalsCells
  36. Folco E, Mathur R, Mori Y, Buckett P, Koren G. A cellular model for long QT syndrome. Trapping of heteromultimeric complexes consisting of truncated Kv1.1 potassium channel polypeptides and native Kv1.4 and Kv1.5 channels in the endoplasmic reticulum. J Biol Chem. 1997 Oct 17; 272(42):26505-10. PMID: 9334228.
    Citations: 7     Fields:    Translation:AnimalsCells
  37. Mori Y, Folco E, Koren G. GH3 cell-specific expression of Kv1.5 gene. Regulation by a silencer containing a dinucleotide repetitive element. J Biol Chem. 1995 Nov 17; 270(46):27788-96. PMID: 7499248.
    Citations: 10     Fields:    Translation:AnimalsCells
  38. Sánchez JJ, Folco EJ, Busconi L, Martone CB, Studdert C, Casalongué CA. Multicatalytic proteinase in fish muscle. Mol Biol Rep. 1995; 21(1):63-9. PMID: 7565667.
    Citations:    Fields:    Translation:Animals
  39. Prado GN, Thomas KM, Suzuki H, LaRosa GJ, Wilkinson N, Folco E, Navarro J. Molecular characterization of a novel rabbit interleukin-8 receptor isotype. J Biol Chem. 1994 Apr 29; 269(17):12391-4. PMID: 8175642.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  40. Mori Y, Matsubara H, Folco E, Siegel A, Koren G. The transcription of a mammalian voltage-gated potassium channel is regulated by cAMP in a cell-specific manner. J Biol Chem. 1993 Dec 15; 268(35):26482-93. PMID: 8253777.
    Citations: 16     Fields:    Translation:AnimalsCells
  41. Busconi L, Folco EJ, Studdert C, Sanchez JJ. Purification and characterization of a latent form of multicatalytic proteinase from fish muscle. Comp Biochem Physiol B. 1992 Jun; 102(2):303-9. PMID: 1617938.
    Citations: 1     Fields:    Translation:AnimalsCells
  42. Martone CB, Busconi L, Folco EJ, Sánchez JJ. Detection of a trypsin-like serine protease and its endogenous inhibitor in hake skeletal muscle. Arch Biochem Biophys. 1991 Aug 15; 289(1):1-5. PMID: 1898057.
    Citations: 2     Fields:    Translation:AnimalsCells
  43. Folco EJ, Busconi L, Martone CB, Sánchez JJ. Fish skeletal muscle contains a novel serine proteinase with an unusual subunit composition. Biochem J. 1989 Oct 15; 263(2):471-5. PMID: 2597118.
    Citations: 1     Fields:    Translation:AnimalsCells
  44. Busconi L, Folco EJ, Martone CB, Trucco RE, Sanchez JJ. Fish muscle cytoskeletal network: its spatial organization and its degradation by an endogenous serine proteinase. Arch Biochem Biophys. 1989 Jan; 268(1):203-8. PMID: 2912376.
    Citations: 2     Fields:    Translation:AnimalsCells
  45. Folco EJ, Busconi L, Martone CB, Sanchez JJ. Multicatalytic proteinase in fish muscle. Arch Biochem Biophys. 1988 Dec; 267(2):599-605. PMID: 3214172.
    Citations: 4     Fields:    Translation:AnimalsCells
  46. Folco EJ, Busconi L, Martone CB, Trucco RE, Sanchez JJ. Activation of an alkaline proteinase from fish skeletal muscle by fatty acids and sodium dodecyl sulphate. Comp Biochem Physiol B. 1988; 91(3):473-6. PMID: 3233924.
    Citations: 3     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.