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Jacob Alexander Sloane, M.D.

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selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Barletta VT, Herranz E, Treaba CA, Mehndiratta A, Ouellette R, Granberg T, Klawiter EC, Ionete C, Sloane JA, Mainero C. In vivo characterization of microglia and myelin relation in multiple sclerosis by combined 11C-PBR28 PET and synthetic MRI. J Neurol. 2023 Mar 02. PMID: 36859627.
    Citations:    Fields:    
  2. Money KM, Baber U, Saart E, Samaan S, Sloane JA. Blunted Post-COVID-19 Humoral Immunity in Patients With CNS Demyelinating Disorders on Anti-CD20 Treatments. Front Neurol. 2022; 13:843081. PMID: 35280260; PMCID: PMC8905651.
    Citations:    
  3. AbdelRazek MA, Casasola M, Mollashahi R, Brodski A, Morin S, Augustynowicz A, Jassim S, Matiello M, Sloane J. Extended B-cell depletion beyond 6-months in patients receiving ocrelizumab or rituximab for CNS demyelinating disease. Mult Scler Relat Disord. 2022 Mar; 59:103505. PMID: 35121247.
    Citations: 1     Fields:    Translation:Humans
  4. Barletta V, Herranz E, Treaba CA, Mehndiratta A, Ouellette R, Mangeat G, Granberg T, Sloane JA, Klawiter EC, Cohen-Adad J, Mainero C. Quantitative 7-Tesla Imaging of Cortical Myelin Changes in Early Multiple Sclerosis. Front Neurol. 2021; 12:714820. PMID: 34539559.
    Citations:    
  5. Money KM, Mahatoo A, Samaan S, Anand P, Baber U, Bailey M, Bakshi R, Bouley A, Bower A, Cahill J, Houtchens M, Katz J, Lathi E, Levit E, Longbrake EE, McAdams M, Napoli S, Raibagkar P, Wade P, Sloane JA. A New England COVID-19 Registry of Patients With CNS Demyelinating Disease: A Pilot Analysis. Neurol Neuroimmunol Neuroinflamm. 2021 09; 8(5). PMID: 34341094; PMCID: PMC8362350.
    Citations: 3     Fields:    Translation:Humans
  6. Treaba CA, Conti A, Klawiter EC, Barletta VT, Herranz E, Mehndiratta A, Russo AW, Sloane JA, Kinkel RP, Toschi N, Mainero C. Cortical and phase rim lesions on 7 T MRI as markers of multiple sclerosis disease progression. Brain Commun. 2021; 3(3):fcab134. PMID: 34704024; PMCID: PMC8361394.
    Citations: 5     
  7. Treaba CA, Herranz E, Barletta VT, Mehndiratta A, Ouellette R, Sloane JA, Klawiter EC, Kinkel RP, Mainero C. The relevance of multiple sclerosis cortical lesions on cortical thinning and their clinical impact as assessed by 7.0-T MRI. J Neurol. 2021 Jul; 268(7):2473-2481. PMID: 33523256.
    Citations: 4     Fields:    Translation:Humans
  8. Miravalle AA, Katz J, Robertson D, Hayward B, Harlow DE, Lebson LA, Sloane JA, Bass AD, Fox EJ. CLICK-MS and MASTER-2 Phase IV trial design: cladribine tablets in suboptimally controlled relapsing multiple sclerosis. Neurodegener Dis Manag. 2021 04; 11(2):99-111. PMID: 33517769.
    Citations: 3     Fields:    Translation:HumansCTClinical Trials
  9. AbdelRazek MA, Hillis JM, Guo Y, Martinez-Lage M, Gholipour T, Sloane J, Cho T, Matiello M. Unilateral Relapsing Primary Angiitis of the CNS: An Entity Suggesting Differences in the Immune Response Between the Cerebral Hemispheres. Neurol Neuroimmunol Neuroinflamm. 2021 03 04; 8(2). PMID: 33402525.
    Citations: 1     Fields:    Translation:Humans
  10. Levit E, Bouley A, Baber U, Djonlagic I, Sloane JA. Brainstem lesions are associated with sleep apnea in multiple sclerosis. Mult Scler J Exp Transl Clin. 2020 Oct-Dec; 6(4):2055217320967955. PMID: 33224518; PMCID: PMC7649856.
    Citations: 1     
  11. Ouellette R, Treaba CA, Granberg T, Herranz E, Barletta V, Mehndiratta A, De Leener B, Tauhid S, Yousuf F, Dupont SM, Klawiter EC, Sloane JA, Bakshi R, Cohen-Adad J, Mainero C. 7 T imaging reveals a gradient in spinal cord lesion distribution in multiple sclerosis. Brain. 2020 10 01; 143(10):2973-2987. PMID: 32935834; PMCID: PMC8453298.
    Citations: 6     Fields:    Translation:Humans
  12. Titelbaum DS, Engisch R, Schwartz ED, Napoli SQ, Sloane JA, Samaan S, Katz JD, Lathi ES. Leptomeningeal Enhancement on 3D-FLAIR MRI in Multiple Sclerosis: Systematic Observations in Clinical Practice. J Neuroimaging. 2020 11; 30(6):917-929. PMID: 32830899.
    Citations: 2     Fields:    Translation:Humans
  13. Mehndiratta A, Treaba CA, Barletta V, Herranz E, Ouellette R, Sloane JA, Klawiter EC, Kinkel RP, Mainero C. Characterization of thalamic lesions and their correlates in multiple sclerosis by ultra-high-field MRI. Mult Scler. 2021 04; 27(5):674-683. PMID: 32584159.
    Citations: 5     Fields:    Translation:Humans
  14. Maghzi AH, Houtchens MK, Preziosa P, Ionete C, Beretich BD, Stankiewicz JM, Tauhid S, Cabot A, Berriosmorales I, Schwartz THW, Sloane JA, Freedman MS, Filippi M, Weiner HL, Bakshi R. COVID-19 in teriflunomide-treated patients with multiple sclerosis. J Neurol. 2020 Oct; 267(10):2790-2796. PMID: 32494856; PMCID: PMC7268971.
    Citations: 33     Fields:    Translation:HumansCellsPHPublic Health
  15. Bouley AJ, Baber U, Egnor E, Samaan S, Sloane JA. Prevalence of Latent Tuberculosis in the Multiple Sclerosis Clinic and Effect of Multiple Sclerosis Treatment on Tuberculosis Testing. Int J MS Care. 2021 Jan-Feb; 23(1):26-30. PMID: 33658903; PMCID: PMC7906031.
    Citations: 2     
  16. Sierra Morales F, Koralnik IJ, Gautam S, Samaan S, Sloane JA. Correction to: Risk factors for lymphopenia in patients with relapsing-remitting multiple sclerosis treated with dimethyl fumarate. J Neurol. 2020 01; 267(1):132. PMID: 31758256.
    Citations:    Fields:    
  17. Morales FS, Koralnik IJ, Gautam S, Samaan S, Sloane JA. Risk factors for lymphopenia in patients with relapsing-remitting multiple sclerosis treated with dimethyl fumarate. J Neurol. 2020 01; 267(1):125-131. PMID: 31583427.
    Citations: 12     Fields:    Translation:Humans
  18. Herranz E, Louapre C, Treaba CA, Govindarajan ST, Ouellette R, Mangeat G, Loggia ML, Cohen-Adad J, Klawiter EC, Sloane JA, Mainero C. Profiles of cortical inflammation in multiple sclerosis by 11C-PBR28 MR-PET and 7 Tesla imaging. Mult Scler. 2020 10; 26(12):1497-1509. PMID: 31368404; PMCID: PMC6994367.
    Citations: 11     Fields:    Translation:Humans
  19. Treaba CA, Granberg TE, Sormani MP, Herranz E, Ouellette RA, Louapre C, Sloane JA, Kinkel RP, Mainero C. Longitudinal Characterization of Cortical Lesion Development and Evolution in Multiple Sclerosis with 7.0-T MRI. Radiology. 2019 06; 291(3):740-749. PMID: 30964421; PMCID: PMC6543899.
    Citations: 26     Fields:    Translation:Humans
  20. Min J, Cohan S, Alvarez E, Sloane J, Phillips JT, van der Walt A, Koulinska I, Fang F, Miller C, Chan A. Real-World Characterization of Dimethyl Fumarate-Related Gastrointestinal Events in Multiple Sclerosis: Management Strategies to Improve Persistence on Treatment and Patient Outcomes. Neurol Ther. 2019 Jun; 8(1):109-119. PMID: 30706431.
    Citations: 11     
  21. Baber U, Bouley A, Egnor E, Sloane JA. Anti-JC virus antibody index changes in rituximab-treated multiple sclerosis patients. J Neurol. 2018 Oct; 265(10):2342-2345. PMID: 30109480.
    Citations: 12     Fields:    Translation:HumansCells
  22. Mangeat G, Badji A, Ouellette R, Treaba CA, Herranz E, Granberg T, Louapre C, Stikov N, Sloane JA, Bellec P, Mainero C, Cohen-Adad J. Changes in structural network are associated with cortical demyelination in early multiple sclerosis. Hum Brain Mapp. 2018 05; 39(5):2133-2146. PMID: 29411457.
    Citations: 10     Fields:    Translation:Humans
  23. Granberg T, Fan Q, Treaba CA, Ouellette R, Herranz E, Mangeat G, Louapre C, Cohen-Adad J, Klawiter EC, Sloane JA, Mainero C. In vivo characterization of cortical and white matter neuroaxonal pathology in early multiple sclerosis. Brain. 2017 Nov 01; 140(11):2912-2926. PMID: 29053798; PMCID: PMC5841207.
    Citations: 58     Fields:    Translation:HumansCells
  24. Lex H, Weisenbach S, Sloane J, Syed S, Rasky E, Freidl W. Social-emotional aspects of quality of life in multiple sclerosis. Psychol Health Med. 2018 04; 23(4):411-423. PMID: 29077480.
    Citations: 7     Fields:    Translation:Humans
  25. Sierra Morales F, Illingworth C, Lin K, Rivera Agosto I, Powell C, Sloane JA, Koralnik IJ. PML-IRIS in an HIV-2-infected patient presenting as Bell's palsy. J Neurovirol. 2017 10; 23(5):789-792. PMID: 28831749; PMCID: PMC5718171.
    Citations: 2     Fields:    Translation:HumansCells
  26. Louapre C, Govindarajan ST, Giannì C, Madigan N, Sloane JA, Treaba CA, Herranz E, Kinkel RP, Mainero C. Heterogeneous pathological processes account for thalamic degeneration in multiple sclerosis: Insights from 7?T imaging. Mult Scler. 2018 10; 24(11):1433-1444. PMID: 28803512.
    Citations: 17     Fields:    Translation:Humans
  27. Siddiqui U, Egnor E, Sloane JA. Biotin supplementation in MS clinically valuable but can alter multiple blood test results. Mult Scler. 2017 04; 23(4):619-620. PMID: 27899554.
    Citations: 5     Fields:    Translation:Humans
  28. Louapre C, Govindarajan ST, Giannì C, Madigan N, Nielsen AS, Sloane JA, Kinkel RP, Mainero C. The association between intra- and juxta-cortical pathology and cognitive impairment in multiple sclerosis by quantitative T2* mapping at 7 T MRI. Neuroimage Clin. 2016; 12:879-886. PMID: 27872810.
    Citations: 13     Fields:    Translation:Humans
  29. Herranz E, Giannì C, Louapre C, Treaba CA, Govindarajan ST, Ouellette R, Loggia ML, Sloane JA, Madigan N, Izquierdo-Garcia D, Ward N, Mangeat G, Granberg T, Klawiter EC, Catana C, Hooker JM, Taylor N, Ionete C, Kinkel RP, Mainero C. Neuroinflammatory component of gray matter pathology in multiple sclerosis. Ann Neurol. 2016 Nov; 80(5):776-790. PMID: 27686563; PMCID: PMC5115951.
    Citations: 71     Fields:    Translation:Humans
  30. Miskin DP, Saadi A, Chikoya L, Sloane JA, Koralnik IJ, Siddiqi OK. Challenges in the diagnosis and treatment of CNS demyelinating disorders in Zambia. Mult Scler J Exp Transl Clin. 2016 Jan-Dec; 2:2055217316657117. PMID: 28607733; PMCID: PMC5433341.
    Citations:    
  31. Zurawski J, Flinn A, Sklover L, Sloane JA. Relapse frequency in transitioning from natalizumab to dimethyl fumarate: assessment of risk factors. J Neurol. 2016 Aug; 263(8):1511-7. PMID: 27193310.
    Citations: 3     Fields:    Translation:Humans
  32. Louapre C, Govindarajan ST, Giannì C, Langkammer C, Sloane JA, Kinkel RP, Mainero C. Beyond focal cortical lesions in MS: An in vivo quantitative and spatial imaging study at 7T. Neurology. 2015 Nov 10; 85(19):1702-9. PMID: 26468411; PMCID: PMC4653110.
    Citations: 20     Fields:    Translation:Humans
  33. Louapre C, Govindarajan ST, Giannì C, Cohen-Adad J, Gregory MD, Nielsen AS, Madigan N, Sloane JA, Kinkel RP, Mainero C. Is the Relationship between Cortical and White Matter Pathologic Changes in Multiple Sclerosis Spatially Specific? A Multimodal 7-T and 3-T MR Imaging Study with Surface and Tract-based Analysis. Radiology. 2016 Feb; 278(2):524-35. PMID: 26334679; PMCID: PMC4734161.
    Citations: 8     Fields:    Translation:HumansCells
  34. Sloane JA, Mainero C, Kinkel RP. No Evidence of Disease Activity in Multiple Sclerosis. JAMA Neurol. 2015 Jul; 72(7):835-6. PMID: 26167901.
    Citations: 3     Fields:    Translation:Humans
  35. Mainero C, Louapre C, Govindarajan ST, Giannì C, Nielsen AS, Cohen-Adad J, Sloane J, Kinkel RP. A gradient in cortical pathology in multiple sclerosis by in vivo quantitative 7 T imaging. Brain. 2015 Apr; 138(Pt 4):932-45. PMID: 25681411; PMCID: PMC4677339.
    Citations: 55     Fields:    Translation:Humans
  36. Chalkias S, Dang X, Bord E, Stein MC, Kinkel RP, Sloane JA, Donnelly M, Ionete C, Houtchens MK, Buckle GJ, Batson S, Koralnik IJ. JC virus reactivation during prolonged natalizumab monotherapy for multiple sclerosis. Ann Neurol. 2014 Jun; 75(6):925-34. PMID: 24687904.
    Citations: 26     Fields:    Translation:HumansCells
  37. Chen CD, Sloane JA, Li H, Aytan N, Giannaris EL, Zeldich E, Hinman JD, Dedeoglu A, Rosene DL, Bansal R, Luebke JI, Kuro-o M, Abraham CR. The antiaging protein Klotho enhances oligodendrocyte maturation and myelination of the CNS. J Neurosci. 2013 Jan 30; 33(5):1927-39. PMID: 23365232; PMCID: PMC3711388.
    Citations: 71     Fields:    Translation:AnimalsCells
  38. Hanafy KA, Sloane JA. Regulation of remyelination in multiple sclerosis. FEBS Lett. 2011 Dec 01; 585(23):3821-8. PMID: 21443876.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  39. Sloane JA, Batt C, Ma Y, Harris ZM, Trapp B, Vartanian T. Hyaluronan blocks oligodendrocyte progenitor maturation and remyelination through TLR2. Proc Natl Acad Sci U S A. 2010 Jun 22; 107(25):11555-60. PMID: 20534434.
    Citations: 162     Fields:    Translation:HumansAnimalsCells
  40. Sloane JA, Blitz D, Margolin Z, Vartanian T. A clear and present danger: endogenous ligands of Toll-like receptors. Neuromolecular Med. 2010 Jun; 12(2):149-63. PMID: 19830599.
    Citations: 30     Fields:    Translation:HumansCells
  41. Cameron JS, Alexopoulou L, Sloane JA, DiBernardo AB, Ma Y, Kosaras B, Flavell R, Strittmatter SM, Volpe J, Sidman R, Vartanian T. Toll-like receptor 3 is a potent negative regulator of axonal growth in mammals. J Neurosci. 2007 Nov 21; 27(47):13033-41. PMID: 18032677.
    Citations: 103     Fields:    Translation:AnimalsCells
  42. Sloane JA, Vartanian TK. Myosin Va controls oligodendrocyte morphogenesis and myelination. J Neurosci. 2007 Oct 17; 27(42):11366-75. PMID: 17942731.
    Citations: 29     Fields:    Translation:AnimalsCells
  43. Sloane JA, Vartanian TK. WAVE1 and regulation of actin nucleation in myelination. Neuroscientist. 2007 Oct; 13(5):486-91. PMID: 17901257.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  44. Ma Y, Li J, Chiu I, Wang Y, Sloane JA, Lü J, Kosaras B, Sidman RL, Volpe JJ, Vartanian T. Toll-like receptor 8 functions as a negative regulator of neurite outgrowth and inducer of neuronal apoptosis. J Cell Biol. 2006 Oct 23; 175(2):209-15. PMID: 17060494; PMCID: PMC2064562.
    Citations: 124     Fields:    Translation:AnimalsCells
  45. Kim HJ, DiBernardo AB, Sloane JA, Rasband MN, Solomon D, Kosaras B, Kwak SP, Vartanian TK. WAVE1 is required for oligodendrocyte morphogenesis and normal CNS myelination. J Neurosci. 2006 May 24; 26(21):5849-59. PMID: 16723544; PMCID: PMC6675261.
    Citations: 50     Fields:    Translation:AnimalsCells
  46. Sloane JA, Hinman JD, Lubonia M, Hollander W, Abraham CR. Age-dependent myelin degeneration and proteolysis of oligodendrocyte proteins is associated with the activation of calpain-1 in the rhesus monkey. J Neurochem. 2003 Jan; 84(1):157-68. PMID: 12485412.
    Citations: 37     Fields:    Translation:AnimalsCells
  47. Sloane JA, Hollander W, Rosene DL, Moss MB, Kemper T, Abraham CR. Astrocytic hypertrophy and altered GFAP degradation with age in subcortical white matter of the rhesus monkey. Brain Res. 2000 Apr 17; 862(1-2):1-10. PMID: 10799662.
    Citations: 24     Fields:    Translation:AnimalsCells
  48. Sloane JA, Hollander W, Moss MB, Rosene DL, Abraham CR. Increased microglial activation and protein nitration in white matter of the aging monkey. Neurobiol Aging. 1999 Jul-Aug; 20(4):395-405. PMID: 10604432.
    Citations: 58     Fields:    Translation:AnimalsCells
  49. Yamin R, Malgeri EG, Sloane JA, McGraw WT, Abraham CR. Metalloendopeptidase EC 3.4.24.15 is necessary for Alzheimer's amyloid-beta peptide degradation. J Biol Chem. 1999 Jun 25; 274(26):18777-84. PMID: 10373494.
    Citations: 14     Fields:    Translation:HumansCells
  50. Sloane JA, Pietropaolo MF, Rosene DL, Moss MB, Peters A, Kemper T, Abraham CR. Lack of correlation between plaque burden and cognition in the aged monkey. Acta Neuropathol. 1997 Nov; 94(5):471-8. PMID: 9386780.
    Citations: 34     Fields:    Translation:Animals
  51. Liang JS, Sloane JA, Wells JM, Abraham CR, Fine RE, Sipe JD. Evidence for local production of acute phase response apolipoprotein serum amyloid A in Alzheimer's disease brain. Neurosci Lett. 1997 Apr 04; 225(2):73-6. PMID: 9147377.
    Citations: 19     Fields:    Translation:Humans
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