Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Daphne Jane Holt, M.D., Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01MH127265 (HOLT, DAPHNE J) Sep 1, 2021 - Jun 30, 2026
    Neurobehavioral mechanisms of social isolation and loneliness in serious mental illness
    Role: Principal Investigator
  2. R01MH109562 (HOLT, DAPHNE J) Sep 21, 2016 - Jun 30, 2021
    Neural mechanisms of social distance in psychosis
    Role: Principal Investigator
  3. R21MH097094 (DICKERSON, BRADFORD C) Sep 19, 2012 - May 31, 2015
    Social cognitive impairment in frontotemporal degeneration and schizophrenia
    Role: Co-Principal Investigator
  4. R01MH095904 (HOLT, DAPHNE J) Mar 1, 2012 - Dec 31, 2017
    The neural basis of deficits in acquisition and extinction of fear in schizophren
    Role: Principal Investigator
  5. K23MH076054 (HOLT, DAPHNE J) Sep 1, 2006 - Feb 24, 2012
    The Neural Basis of Delusions in Schizophrenia: Studies of Emotional Perception
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Tootell RBH, Zapetis SL, Babadi B, Nasiriavanaki Z, Hughes DE, Mueser K, Otto M, Pace-Schott E, Holt DJ. Psychological and physiological evidence for an initial 'Rough Sketch' calculation of personal space. Sci Rep. 2021 Oct 25; 11(1):20960. PMID: 34697390.
    Citations:    Fields:    
  2. Tuominen L, Romaniuk L, Milad MR, Goff DC, Hall J, Holt DJ. Impairment in acquisition of conditioned fear in schizophrenia. Neuropsychopharmacology. 2021 Sep 29. PMID: 34588608.
    Citations:    Fields:    
  3. Webler RD, Berg H, Fhong K, Tuominen L, Holt DJ, Morey RA, Lange I, Burton PC, Fullana MA, Radua J, Lissek S. The neurobiology of human fear generalization: meta-analysis and working neural model. Neurosci Biobehav Rev. 2021 09; 128:421-436. PMID: 34242718.
    Citations:    Fields:    Translation:Humans
  4. Wang J, Hart KL, Qi W, Ardekani BA, Li C, Marx J, Freudenreich O, Cather C, Holt D, Bello I, Diminich ED, Tang Y, Worthington M, Zeng B, Wu R, Fan X, Zhao J, Wang J, Goff DC. Association of Aripiprazole With Reduced Hippocampal Atrophy During Maintenance Treatment of First-Episode Schizophrenia. J Clin Psychopharmacol. 2021 May-Jun 01; 41(3):244-249. PMID: 33814546.
    Citations:    Fields:    
  5. Wright AC, Cather C, Farabaugh A, Terechina O, Pedrelli P, Nyer M, Fava M, Holt DJ. Relationship between cannabis use and psychotic experiences in college students. Schizophr Res. 2021 05; 231:198-204. PMID: 33887647.
    Citations:    Fields:    Translation:HumansAnimals
  6. Qi W, Blessing E, Li C, Ardekani BA, Hart KL, Marx J, Freudenreich O, Cather C, Holt D, Bello I, Diminich ED, Tang Y, Worthington M, Zeng B, Wu R, Fan X, Troxel A, Zhao J, Wang J, Goff DC. Effect of citalopram on hippocampal volume in first-episode schizophrenia: Structural MRI results from the DECIFER trial. Psychiatry Res Neuroimaging. 2021 06 30; 312:111286. PMID: 33857750.
    Citations:    Fields:    Translation:Humans
  7. Nasiriavanaki Z, Barbour T, Farabaugh AH, Fava M, Holmes AJ, Tootell RBH, Holt DJ. Anxious attachment is associated with heightened responsivity of a parietofrontal cortical network that monitors peri-personal space. Neuroimage Clin. 2021; 30:102585. PMID: 33773165.
    Citations: 2     Fields:    Translation:Humans
  8. Tuominen L, DeCross SN, Boeke E, Cassidy CM, Freudenreich O, Shinn AK, Tootell RBH, Holt DJ. Neural Abnormalities in Fear Generalization in Schizophrenia and Associations With Negative Symptoms. Biol Psychiatry Cogn Neurosci Neuroimaging. 2021 Jan 29. PMID: 33524600.
    Citations:    Fields:    
  9. Wang D, Peng X, Pelletier-Baldelli A, Orlov N, Farabaugh A, Nasr S, Eryilmaz H, Fava M, Holmes AJ, Roffman JL, Liu H, Holt DJ. Altered temporal, but intact spatial, features of transient network dynamics in psychosis. Mol Psychiatry. 2021 06; 26(6):2493-2503. PMID: 33462330.
    Citations: 1     Fields:    Translation:Humans
  10. Park ER, Sylvia LG, Streck JM, Luberto CM, Stanton AM, Perez GK, Baim M, Bliss CC, Convery MS, Crute S, Denninger JW, Donelan K, Dossett ML, Fava M, Fredriksson S, Fricchione G, George N, Hall DL, Hart BR, Herman J, Hirschberg A, Holt D, Looby SE, Malloy L, Meek J, Mehta DH, Millstein RA, Mizrach H, Rosa K, Slawsby E, Stupinski AC, Traeger L, Vanderkruik R, Vogeli C, Wilhelm S. Launching a resiliency group program to assist frontline clinicians in meeting the challenges of the COVID-19 pandemic: Results of a hospital-based systems trial. Gen Hosp Psychiatry. 2021 Jan-Feb; 68:111-112. PMID: 33229013.
    Citations:    Fields:    Translation:Humans
  11. Worthington MA, Petkova E, Freudenreich O, Cather C, Holt D, Bello I, Diminich E, Tang Y, Ardekani BA, Zeng B, Wu R, Fan X, Zhao J, Wang J, Goff DC. Air pollution and hippocampal atrophy in first episode schizophrenia. Schizophr Res. 2020 04; 218:63-69. PMID: 32169403.
    Citations:    Fields:    Translation:HumansPHPublic Health
  12. Pelletier-Baldelli A, Holt DJ. Are Negative Symptoms Merely the "Real World" Consequences of Deficits in Social Cognition? Schizophr Bull. 2020 02 26; 46(2):236-241. PMID: 31598707.
    Citations: 5     Fields:    Translation:Humans
  13. Burke AS, Shapero BG, Pelletier-Baldelli A, Deng WY, Nyer MB, Leathem L, Namey L, Landa C, Cather C, Holt DJ. Rationale, Methods, Feasibility, and Preliminary Outcomes of a Transdiagnostic Prevention Program for At-Risk College Students. Front Psychiatry. 2019; 10:1030. PMID: 32158406.
    Citations: 3     
  14. Barbour T, Holmes AJ, Farabaugh AH, DeCross SN, Coombs G, Boeke EA, Wolthusen RPF, Nyer M, Pedrelli P, Fava M, Holt DJ. Elevated Amygdala Activity in Young Adults With Familial Risk for Depression: A Potential Marker of Low Resilience. Biol Psychiatry Cogn Neurosci Neuroimaging. 2020 02; 5(2):194-202. PMID: 31948836.
    Citations: 1     Fields:    Translation:Humans
  15. Ho NF, Holt DJ, Cheung M, Iglesias JE, Goh A, Wang M, Lim JKW, de Souza J, Poh JS, See YM, Adcock RA, Wood SJ, Chee MWL, Lee J, Zhou J. Correction: Progressive decline in hippocampal CA1 volume in individuals at ultra-high-risk for psychosis who do not remit: findings from the longitudinal youth at risk study. Neuropsychopharmacology. 2019 Nov; 44(12):2144. PMID: 31413353.
    Citations: 1     Fields:    
  16. Holt DJ. Deficient Hippocampal Habituation in Psychosis: A Manifestation of Hippocampal Overactivity? Biol Psychiatry Cogn Neurosci Neuroimaging. 2019 11; 4(11):938-939. PMID: 31699302.
    Citations:    Fields:    Translation:Humans
  17. Ge T, Chen CY, Doyle AE, Vettermann R, Tuominen LJ, Holt DJ, Sabuncu MR, Smoller JW. The Shared Genetic Basis of Educational Attainment and Cerebral Cortical Morphology. Cereb Cortex. 2019 07 22; 29(8):3471-3481. PMID: 30272126.
    Citations: 2     Fields:    Translation:Humans
  18. Gilbert TM, Zürcher NR, Catanese MC, Tseng CJ, Di Biase MA, Lyall AE, Hightower BG, Parmar AJ, Bhanot A, Wu CJ, Hibert ML, Kim M, Mahmood U, Stufflebeam SM, Schroeder FA, Wang C, Roffman JL, Holt DJ, Greve DN, Pasternak O, Kubicki M, Wey HY, Hooker JM. Neuroepigenetic signatures of age and sex in the living human brain. Nat Commun. 2019 07 03; 10(1):2945. PMID: 31270332.
    Citations: 8     Fields:    Translation:Humans
  19. Chen X, Fan X, Hu Y, Zuo C, Whitfield-Gabrieli S, Holt D, Gong Q, Yang Y, Pizzagalli DA, Du F, Ongur D. Regional GABA Concentrations Modulate Inter-network Resting-state Functional Connectivity. Cereb Cortex. 2019 04 01; 29(4):1607-1618. PMID: 29608677.
    Citations: 10     Fields:    Translation:Humans
  20. DeCross SN, Farabaugh AH, Holmes AJ, Ward M, Boeke EA, Wolthusen RPF, Coombs G, Nyer M, Fava M, Buckner RL, Holt DJ. Increased amygdala-visual cortex connectivity in youth with persecutory ideation. Psychol Med. 2020 01; 50(2):273-283. PMID: 30744715.
    Citations: 3     Fields:    Translation:Humans
  21. Goff DC, Freudenreich O, Cather C, Holt D, Bello I, Diminich E, Tang Y, Ardekani BA, Worthington M, Zeng B, Wu R, Fan X, Li C, Troxel A, Wang J, Zhao J. Citalopram in first episode schizophrenia: The DECIFER trial. Schizophr Res. 2019 06; 208:331-337. PMID: 30709746.
    Citations: 3     Fields:    Translation:Humans
  22. Tuominen L, Boeke E, DeCross S, Wolthusen RP, Nasr S, Milad M, Vangel M, Tootell R, Holt D. The relationship of perceptual discrimination to neural mechanisms of fear generalization. Neuroimage. 2019 03; 188:445-455. PMID: 30572112.
    Citations: 4     Fields:    Translation:Humans
  23. Gilbert TM, Zürcher NR, Wu CJ, Bhanot A, Hightower BG, Kim M, Albrecht DS, Wey HY, Schroeder FA, Rodriguez-Thompson A, Morin TM, Hart KL, Pellegrini AM, Riley MM, Wang C, Stufflebeam SM, Haggarty SJ, Holt DJ, Loggia ML, Perlis RH, Brown HE, Roffman JL, Hooker JM. PET neuroimaging reveals histone deacetylase dysregulation in schizophrenia. J Clin Invest. 2019 01 02; 129(1):364-372. PMID: 30530989.
    Citations: 12     Fields:    Translation:HumansCTClinical Trials
  24. Shapero BG, Farabaugh A, Terechina O, DeCross S, Cheung JC, Fava M, Holt DJ. Understanding the effects of emotional reactivity on depression and suicidal thoughts and behaviors: Moderating effects of childhood adversity and resilience. J Affect Disord. 2019 02 15; 245:419-427. PMID: 30423470.
    Citations: 4     Fields:    Translation:Humans
  25. Blokland GAM, Del Re EC, Mesholam-Gately RI, Jovicich J, Trampush JW, Keshavan MS, DeLisi LE, Walters JTR, Turner JA, Malhotra AK, Lencz T, Shenton ME, Voineskos AN, Rujescu D, Giegling I, Kahn RS, Roffman JL, Holt DJ, Ehrlich S, Kikinis Z, Dazzan P, Murray RM, Di Forti M, Lee J, Sim K, Lam M, Wolthusen RPF, de Zwarte SMC, Walton E, Cosgrove D, Kelly S, Maleki N, Osiecki L, Picchioni MM, Bramon E, Russo M, David AS, Mondelli V, Reinders AATS, Falcone MA, Hartmann AM, Konte B, Morris DW, Gill M, Corvin AP, Cahn W, Ho NF, Liu JJ, Keefe RSE, Gollub RL, Manoach DS, Calhoun VD, Schulz SC, Sponheim SR, Goff DC, Buka SL, Cherkerzian S, Thermenos HW, Kubicki M, Nestor PG, Dickie EW, Vassos E, Ciufolini S, Reis Marques T, Crossley NA, Purcell SM, Smoller JW, van Haren NEM, Toulopoulou T, Donohoe G, Goldstein JM, Seidman LJ, McCarley RW, Petryshen TL. The Genetics of Endophenotypes of Neurofunction to Understand Schizophrenia (GENUS) consortium: A collaborative cognitive and neuroimaging genetics project. Schizophr Res. 2018 05; 195:306-317. PMID: 28982554.
    Citations: 10     Fields:    Translation:Humans
  26. Wolthusen RPF, Coombs G, Boeke EA, Ehrlich S, DeCross SN, Nasr S, Holt DJ. Correlation Between Levels of Delusional Beliefs and Perfusion of the Hippocampus and an Associated Network in a Non-Help-Seeking Population. Biol Psychiatry Cogn Neurosci Neuroimaging. 2018 02; 3(2):178-186. PMID: 29529413.
    Citations: 1     Fields:    Translation:Humans
  27. Ho NF, Holt DJ, Cheung M, Iglesias JE, Goh A, Wang M, Lim JK, de Souza J, Poh JS, See YM, Adcock AR, Wood SJ, Chee MW, Lee J, Zhou J. Progressive Decline in Hippocampal CA1 Volume in Individuals at Ultra-High-Risk for Psychosis Who Do Not Remit: Findings from the Longitudinal Youth at Risk Study. Neuropsychopharmacology. 2017 May; 42(6):1361-1370. PMID: 28079061.
    Citations: 26     Fields:    Translation:Humans
  28. Holt DJ. A Pathway to Understanding Emotional Dysfunction in Schizophrenia. JAMA Psychiatry. 2016 06 01; 73(6):555-6. PMID: 27145062.
    Citations:    Fields:    Translation:Humans
  29. Holt DJ, Boeke EA, Coombs G, DeCross SN, Cassidy BS, Stufflebeam S, Rauch SL, Tootell RBH. Corrigendum to abnormalities in personal space and parietal-frontal function in schizophrenia. Neuroimage Clin. 2016; 11:538. PMID: 27144121.
    Citations:    Fields:    
  30. Ho NF, Iglesias JE, Sum MY, Kuswanto CN, Sitoh YY, De Souza J, Hong Z, Fischl B, Roffman JL, Zhou J, Sim K, Holt DJ. Progression from selective to general involvement of hippocampal subfields in schizophrenia. Mol Psychiatry. 2017 01; 22(1):142-152. PMID: 26903271.
    Citations: 45     Fields:    Translation:Humans
  31. Brent BK, Rosso IM, Thermenos HW, Holt DJ, Faraone SV, Makris N, Tsuang MT, Seidman LJ. Alterations of lateral temporal cortical gray matter and facial memory as vulnerability indicators for schizophrenia: An MRI study in youth at familial high-risk for schizophrenia. Schizophr Res. 2016 Jan; 170(1):123-9. PMID: 26621001.
    Citations: 2     Fields:    Translation:Humans
  32. Rosenbaum BL, Bui E, Marin MF, Holt DJ, Lasko NB, Pitman RK, Orr SP, Milad MR. Reprint of: "Demographic factors predict magnitude of conditioned fear". Int J Psychophysiol. 2015 Dec; 98(3 Pt 2):606-11. PMID: 26608179.
    Citations:    Fields:    
  33. Wang D, Buckner RL, Fox MD, Holt DJ, Holmes AJ, Stoecklein S, Langs G, Pan R, Qian T, Li K, Baker JT, Stufflebeam SM, Wang K, Wang X, Hong B, Liu H. Parcellating cortical functional networks in individuals. Nat Neurosci. 2015 Dec; 18(12):1853-60. PMID: 26551545.
    Citations: 130     Fields:    Translation:Humans
  34. Maher S, Ekstrom T, Holt D, Ongur D, Chen Y. The Core Brain Region for Face Processing in Schizophrenia Lacks Face Selectivity. Schizophr Bull. 2016 May; 42(3):666-74. PMID: 26453911.
    Citations: 7     Fields:    Translation:Humans
  35. Wolthusen RP, Hass J, Walton E, Turner JA, Rössner V, Sponheim SR, Ho BC, Holt DJ, Gollub RL, Calhoun V, Ehrlich S. Genetic underpinnings of left superior temporal gyrus thickness in patients with schizophrenia. World J Biol Psychiatry. 2015 Aug 07; 1-11. PMID: 26249676.
    Citations: 5     Fields:    
  36. Holt DJ, Boeke EA, Coombs G, DeCross SN, Cassidy BS, Stufflebeam S, Rauch SL, Tootell RB. Abnormalities in personal space and parietal-frontal function in schizophrenia. Neuroimage Clin. 2015; 9:233-43. PMID: 26484048.
    Citations: 15     Fields:    Translation:Humans
  37. Rosenbaum BL, Bui E, Marin MF, Holt DJ, Lasko NB, Pitman RK, Orr SP, Milad MR. Demographic factors predict magnitude of conditioned fear. Int J Psychophysiol. 2015 Oct; 98(1):59-64. PMID: 26151498.
    Citations: 6     Fields:    Translation:Humans
  38. Mueller S, Wang D, Pan R, Holt DJ, Liu H. Abnormalities in hemispheric specialization of caudate nucleus connectivity in schizophrenia. JAMA Psychiatry. 2015 Jun; 72(6):552-60. PMID: 25830688.
    Citations: 18     Fields:    Translation:Humans
  39. Nyer M, Mischoulon D, Alpert JE, Holt DJ, Brill CD, Yeung A, Pedrelli P, Baer L, Dording C, Huz I, Fisher L, Fava M, Farabaugh A. College students with depressive symptoms with and without fatigue: Differences in functioning, suicidality, anxiety, and depressive severity. Ann Clin Psychiatry. 2015 May; 27(2):100-8. PMID: 25954936.
    Citations: 4     Fields:    Translation:Humans
  40. Farabaugh A, Fisher L, Nyer M, Holt D, Cohen M, Baer L, Shapero BG, Huz I, Cardoos A, Fava M, Alpert JE. Similar changes in cognitions following cognitive-behavioral therapy or escitalopram for major depressive disorder: Implications for mechanisms of change. Ann Clin Psychiatry. 2015 May; 27(2):118-26. PMID: 25954938.
    Citations: 4     Fields:    Translation:Humans
  41. Hass J, Walton E, Kirsten H, Turner J, Wolthusen R, Roessner V, Sponheim SR, Holt D, Gollub R, Calhoun VD, Ehrlich S. Complexin2 modulates working memory-related neural activity in patients with schizophrenia. Eur Arch Psychiatry Clin Neurosci. 2015 Mar; 265(2):137-45. PMID: 25297695.
    Citations: 4     Fields:    Translation:Humans
  42. Holt DJ, Boeke EA, Wolthusen RP, Nasr S, Milad MR, Tootell RB. A parametric study of fear generalization to faces and non-face objects: relationship to discrimination thresholds. Front Hum Neurosci. 2014; 8:624. PMID: 25249955.
    Citations: 11     
  43. Brent BK, Seidman LJ, Coombs G, Keshavan MS, Moran JM, Holt DJ. Neural responses during social reflection in relatives of schizophrenia patients: relationship to subclinical delusions. Schizophr Res. 2014 Aug; 157(1-3):292-8. PMID: 24951401.
    Citations: 6     Fields:    Translation:Humans
  44. Coombs G, Loggia ML, Greve DN, Holt DJ. Amygdala perfusion is predicted by its functional connectivity with the ventromedial prefrontal cortex and negative affect. PLoS One. 2014; 9(5):e97466. PMID: 24816735.
    Citations: 9     Fields:    Translation:Humans
  45. Holt DJ, Cassidy BS, Yue X, Rauch SL, Boeke EA, Nasr S, Tootell RB, Coombs G. Neural correlates of personal space intrusion. J Neurosci. 2014 Mar 19; 34(12):4123-34. PMID: 24647934.
    Citations: 28     Fields:    Translation:Humans
  46. Brent BK, Holt DJ, Keshavan MS, Seidman LJ, Fonagy P. Mentalization-based treatment for psychosis: linking an attachment-based model to the psychotherapy for impaired mental state understanding in people with psychotic disorders. Isr J Psychiatry Relat Sci. 2014; 51(1):17-24. PMID: 24858631.
    Citations: 7     Fields:    Translation:Humans
  47. Schneider CE, White T, Hass J, Geisler D, Wallace SR, Roessner V, Holt DJ, Calhoun VD, Gollub RL, Ehrlich S. Smoking status as a potential confounder in the study of brain structure in schizophrenia. J Psychiatr Res. 2014 Mar; 50:84-91. PMID: 24373929.
    Citations: 15     Fields:    Translation:HumansCells
  48. Pedrelli P, Nyer M, Holt D, Bakow BR, Fava M, Baer L, Cassiello C, Mulligan M, Cusin C, Farabaugh A. Correlates of irritability in college students with depressive symptoms. J Nerv Ment Dis. 2013 Nov; 201(11):953-8. PMID: 24177482.
    Citations: 6     Fields:    Translation:Humans
  49. Schwartz CE, Holt DJ, Rosenbaum JF. Methodological challenges of moving beyond DSM categories: transdiagnostic studies of frontolimbic connectivity changes in vulnerable individuals. Biol Psychiatry. 2013 Aug 15; 74(4):240-1. PMID: 23885753.
    Citations:    Fields:    Translation:Humans
  50. Brent BK, Seidman LJ, Thermenos HW, Holt DJ, Keshavan MS. Self-disturbances as a possible premorbid indicator of schizophrenia risk: a neurodevelopmental perspective. Schizophr Res. 2014 Jan; 152(1):73-80. PMID: 23932148.
    Citations: 21     Fields:    Translation:Humans
  51. Soskin DP, Holt DJ, Sacco GR, Fava M. Incentive salience: novel treatment strategies for major depression. CNS Spectr. 2013 Dec; 18(6):307-14. PMID: 23903027.
    Citations: 7     Fields:    Translation:HumansAnimals
  52. Nyer M, Farabaugh A, Fehling K, Soskin D, Holt D, Papakostas GI, Pedrelli P, Fava M, Pisoni A, Vitolo O, Mischoulon D. Relationship between sleep disturbance and depression, anxiety, and functioning in college students. Depress Anxiety. 2013 Sep; 30(9):873-80. PMID: 23681944.
    Citations: 24     Fields:    Translation:Humans
  53. Yue X, Nasr S, Devaney KJ, Holt DJ, Tootell RB. fMRI analysis of contrast polarity in face-selective cortex in humans and monkeys. Neuroimage. 2013 Aug 01; 76:57-69. PMID: 23518007.
    Citations: 4     Fields:    Translation:HumansAnimals
  54. Ho NF, Hooker JM, Sahay A, Holt DJ, Roffman JL. In vivo imaging of adult human hippocampal neurogenesis: progress, pitfalls and promise. Mol Psychiatry. 2013 Apr; 18(4):404-16. PMID: 23439487.
    Citations: 33     Fields:    Translation:HumansAnimals
  55. Nyer M, Holt DJ, Pedrelli P, Fava M, Ameral V, Cassiello CF, Nock MK, Ross M, Hutchinson D, Farabaugh A. Factors that distinguish college students with depressive symptoms with and without suicidal thoughts. Ann Clin Psychiatry. 2013 Feb; 25(1):41-9. PMID: 23376869.
    Citations: 12     Fields:    Translation:Humans
  56. Linnman C, Coombs G, Goff DC, Holt DJ. Lack of insula reactivity to aversive stimuli in schizophrenia. Schizophr Res. 2013 Jan; 143(1):150-7. PMID: 23201307.
    Citations: 13     Fields:    Translation:Humans
  57. Brent BK, Coombs G, Keshavan MS, Seidman LJ, Moran JM, Holt DJ. Subclinical delusional thinking predicts lateral temporal cortex responses during social reflection. Soc Cogn Affect Neurosci. 2014 Mar; 9(3):273-82. PMID: 23160817.
    Citations: 9     Fields:    Translation:HumansCTClinical Trials
  58. Holt DJ, Coombs G, Zeidan MA, Goff DC, Milad MR. Failure of neural responses to safety cues in schizophrenia. Arch Gen Psychiatry. 2012 Sep; 69(9):893-903. PMID: 22945619.
    Citations: 50     Fields:    Translation:Humans
  59. Farabaugh A, Bitran S, Nyer M, Holt DJ, Pedrelli P, Shyu I, Hollon SD, Zisook S, Baer L, Busse W, Petersen TJ, Pender M, Tucker DD, Fava M. Depression and suicidal ideation in college students. Psychopathology. 2012; 45(4):228-34. PMID: 22627683.
    Citations: 19     Fields:    Translation:HumansPHPublic Health
  60. Lebron-Milad K, Abbs B, Milad MR, Linnman C, Rougemount-Bücking A, Zeidan MA, Holt DJ, Goldstein JM. Sex differences in the neurobiology of fear conditioning and extinction: a preliminary fMRI study of shared sex differences with stress-arousal circuitry. Biol Mood Anxiety Disord. 2012 Apr 16; 2:7. PMID: 22738021.
    Citations: 37     
  61. Zeidan MA, Lebron-Milad K, Thompson-Hollands J, Im JJ, Dougherty DD, Holt DJ, Orr SP, Milad MR. Test-retest reliability during fear acquisition and fear extinction in humans. CNS Neurosci Ther. 2012 Apr; 18(4):313-7. PMID: 21592319.
    Citations: 18     Fields:    Translation:Humans
  62. Michael AM, King MD, Ehrlich S, Pearlson G, White T, Holt DJ, Andreasen NC, Sakoglu U, Ho BC, Schulz SC, Calhoun VD. A Data-Driven Investigation of Gray Matter-Function Correlations in Schizophrenia during a Working Memory Task. Front Hum Neurosci. 2011; 5:71. PMID: 21886614.
    Citations: 13     
  63. Ehrlich S, Yendiki A, Greve DN, Manoach DS, Ho BC, White T, Schulz SC, Goff DC, Gollub RL, Holt DJ. Striatal function in relation to negative symptoms in schizophrenia. Psychol Med. 2012 Feb; 42(2):267-82. PMID: 21733291.
    Citations: 19     Fields:    Translation:Humans
  64. Holt DJ, Cassidy BS, Andrews-Hanna JR, Lee SM, Coombs G, Goff DC, Gabrieli JD, Moran JM. An anterior-to-posterior shift in midline cortical activity in schizophrenia during self-reflection. Biol Psychiatry. 2011 Mar 01; 69(5):415-23. PMID: 21144498.
    Citations: 61     Fields:    
  65. Yeo BT, Sabuncu MR, Vercauteren T, Holt DJ, Amunts K, Zilles K, Golland P, Fischl B. Learning task-optimal registration cost functions for localizing cytoarchitecture and function in the cerebral cortex. IEEE Trans Med Imaging. 2010 Jul; 29(7):1424-41. PMID: 20529736.
    Citations: 24     Fields:    Translation:Humans
  66. Yue X, Cassidy BS, Devaney KJ, Holt DJ, Tootell RB. Lower-level stimulus features strongly influence responses in the fusiform face area. Cereb Cortex. 2011 Jan; 21(1):35-47. PMID: 20375074.
    Citations: 39     Fields:    Translation:Humans
  67. Ehrlich S, Morrow EM, Roffman JL, Wallace SR, Naylor M, Bockholt HJ, Lundquist A, Yendiki A, Ho BC, White T, Manoach DS, Clark VP, Calhoun VD, Gollub RL, Holt DJ. The COMT Val108/158Met polymorphism and medial temporal lobe volumetry in patients with schizophrenia and healthy adults. Neuroimage. 2010 Nov 15; 53(3):992-1000. PMID: 20026221.
    Citations: 34     Fields:    Translation:Humans
  68. Holt DJ, Lynn SK, Kuperberg GR. Neurophysiological correlates of comprehending emotional meaning in context. J Cogn Neurosci. 2009 Nov; 21(11):2245-62. PMID: 18855550.
    Citations: 31     Fields:    Translation:Humans
  69. Gasic GP, Smoller JW, Perlis RH, Sun M, Lee S, Kim BW, Lee MJ, Holt DJ, Blood AJ, Makris N, Kennedy DK, Hoge RD, Calhoun J, Fava M, Gusella JF, Breiter HC. BDNF, relative preference, and reward circuitry responses to emotional communication. Am J Med Genet B Neuropsychiatr Genet. 2009 Sep 05; 150B(6):762-81. PMID: 19388013.
    Citations: 34     Fields:    Translation:Humans
  70. Holt DJ, Lakshmanan B, Freudenreich O, Goff DC, Rauch SL, Kuperberg GR. Dysfunction of a cortical midline network during emotional appraisals in schizophrenia. Schizophr Bull. 2011 Jan; 37(1):164-76. PMID: 19605517.
    Citations: 24     Fields:    Translation:Humans
  71. Kuperberg GR, Kreher DA, Swain A, Goff DC, Holt DJ. Selective emotional processing deficits to social vignettes in schizophrenia: an ERP study. Schizophr Bull. 2011 Jan; 37(1):148-63. PMID: 19564165.
    Citations: 7     Fields:    Translation:Humans
  72. Norton D, McBain R, Holt DJ, Ongur D, Chen Y. Association of impaired facial affect recognition with basic facial and visual processing deficits in schizophrenia. Biol Psychiatry. 2009 Jun 15; 65(12):1094-8. PMID: 19268917.
    Citations: 40     Fields:    Translation:Humans
  73. Holt DJ, Lebron-Milad K, Milad MR, Rauch SL, Pitman RK, Orr SP, Cassidy BS, Walsh JP, Goff DC. Extinction memory is impaired in schizophrenia. Biol Psychiatry. 2009 Mar 15; 65(6):455-63. PMID: 18986648.
    Citations: 86     Fields:    Translation:Humans
  74. Perlis RH, Holt DJ, Smoller JW, Blood AJ, Lee S, Kim BW, Lee MJ, Sun M, Makris N, Kennedy DK, Rooney K, Dougherty DD, Hoge R, Rosenbaum JF, Fava M, Gusella J, Gasic GP, Breiter HC. Association of a polymorphism near CREB1 with differential aversion processing in the insula of healthy participants. Arch Gen Psychiatry. 2008 Aug; 65(8):882-92. PMID: 18678793.
    Citations: 17     Fields:    Translation:Humans
  75. Freudenreich O, Holt DJ, Cather C, Goff DC. The evaluation and management of patients with first-episode schizophrenia: a selective, clinical review of diagnosis, treatment, and prognosis. Harv Rev Psychiatry. 2007 Sep-Oct; 15(5):189-211. PMID: 17924256.
    Citations: 6     Fields:    Translation:Humans
  76. Kuperberg GR, Deckersbach T, Holt DJ, Goff D, West WC. Increased temporal and prefrontal activity in response to semantic associations in schizophrenia. Arch Gen Psychiatry. 2007 Feb; 64(2):138-51. PMID: 17283282.
    Citations: 41     Fields:    Translation:Humans
  77. Freudenreich O, Cather C, Holt D. Stimulant misuse in college for "pseudo-attention deficit disorder" during schizophrenia prodrome. Am J Psychiatry. 2006 Nov; 163(11):2019. PMID: 17074965.
    Citations:    Fields:    Translation:Humans
  78. Holt DJ, Titone D, Long LS, Goff DC, Cather C, Rauch SL, Judge A, Kuperberg GR. The misattribution of salience in delusional patients with schizophrenia. Schizophr Res. 2006 Apr; 83(2-3):247-56. PMID: 16540291.
    Citations: 30     Fields:    Translation:Humans
  79. Holt DJ, Kunkel L, Weiss AP, Goff DC, Wright CI, Shin LM, Rauch SL, Hootnick J, Heckers S. Increased medial temporal lobe activation during the passive viewing of emotional and neutral facial expressions in schizophrenia. Schizophr Res. 2006 Feb 28; 82(2-3):153-62. PMID: 16377154.
    Citations: 95     Fields:    Translation:Humans
  80. Holt DJ, Bachus SE, Hyde TM, Wittie M, Herman MM, Vangel M, Saper CB, Kleinman JE. Reduced density of cholinergic interneurons in the ventral striatum in schizophrenia: an in situ hybridization study. Biol Psychiatry. 2005 Sep 01; 58(5):408-16. PMID: 16023618.
    Citations: 28     Fields:    Translation:HumansCells
  81. Holt DJ, Weiss AP, Rauch SL, Wright CI, Zalesak M, Goff DC, Ditman T, Welsh RC, Heckers S. Sustained activation of the hippocampus in response to fearful faces in schizophrenia. Biol Psychiatry. 2005 May 01; 57(9):1011-9. PMID: 15860342.
    Citations: 59     Fields:    Translation:Humans
  82. Holt DJ, Phillips KA, Shapiro ER, Becker AE. "My Face Is My Fate": biological and psychosocial approaches to the treatment of a woman with obsessions and delusions. Harv Rev Psychiatry. 2003 May-Jun; 11(3):142-54. PMID: 12893504.
    Citations: 1     Fields:    Translation:Humans
  83. Holt DJ, Herman MM, Hyde TM, Kleinman JE, Sinton CM, German DC, Hersh LB, Graybiel AM, Saper CB. Evidence for a deficit in cholinergic interneurons in the striatum in schizophrenia. Neuroscience. 1999; 94(1):21-31. PMID: 10613493.
    Citations: 35     Fields:    Translation:HumansCells
  84. Holt DJ, Graybiel AM, Saper CB. Neurochemical architecture of the human striatum. J Comp Neurol. 1997 Jul 21; 384(1):1-25. PMID: 9214537.
    Citations: 50     Fields:    Translation:HumansCells
  85. Holt DJ, Hersh LB, Saper CB. Cholinergic innervation in the human striatum: a three-compartment model. Neuroscience. 1996 Sep; 74(1):67-87. PMID: 8843078.
    Citations: 13     Fields:    Translation:HumansCells
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact contactcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Holt's Networks
Click the
buttons for more information and interactive visualizations!
Concepts (258)
Co-Authors (102)
Similar People (60)
Same Department 
Physical Neighbors
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.