Harvard Catalyst Profiles

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Daphne Jane Holt, M.D., Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01MH109562 (HOLT, DAPHNE J) Sep 21, 2016 - Jun 30, 2021
    NIH/NIMH
    Neural mechanisms of social distance in psychosis
    Role: Principal Investigator
  2. R21MH097094 (DICKERSON, BRADFORD C) Sep 19, 2012 - May 31, 2014
    NIH/NIMH
    Social cognitive impairment in frontotemporal degeneration and schizophrenia
    Role: Co-Principal Investigator
  3. R01MH095904 (HOLT, DAPHNE J) Mar 1, 2012 - Dec 31, 2016
    NIH/NIMH
    The neural basis of deficits in acquisition and extinction of fear in schizophren
    Role: Principal Investigator
  4. K23MH076054 (HOLT, DAPHNE J) Mar 1, 2010 - Feb 28, 2011
    NIH/NIMH
    The Neural Basis of Delusions in Schizophrenia: Studies of Emotional Perception
    Role: Principal Investigator
  5. F31MH010522 (HOLT, DAPHNE J) Mar 25, 1994
    NIH/NIMH
    NEUROCHEMICAL ORGANIZATION OF THE HUMAN STRIATUM
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Worthington MA, Petkova E, Freudenreich O, Cather C, Holt D, Bello I, Diminich E, Tang Y, Ardekani BA, Zeng B, Wu R, Fan X, Zhao J, Wang J, Goff DC. Air pollution and hippocampal atrophy in first episode schizophrenia. Schizophr Res. 2020 04; 218:63-69. PMID: 32169403.
    Citations:    Fields:    
  2. Pelletier-Baldelli A, Holt DJ. Are Negative Symptoms Merely the "Real World" Consequences of Deficits in Social Cognition? Schizophr Bull. 2020 02 26; 46(2):236-241. PMID: 31598707.
    Citations: 2     Fields:    
  3. Burke AS, Shapero BG, Pelletier-Baldelli A, Deng WY, Nyer MB, Leathem L, Namey L, Landa C, Cather C, Holt DJ. Rationale, Methods, Feasibility, and Preliminary Outcomes of a Transdiagnostic Prevention Program for At-Risk College Students. Front Psychiatry. 2019; 10:1030. PMID: 32158406.
    Citations: 1     
  4. Barbour T, Holmes AJ, Farabaugh AH, DeCross SN, Coombs G, Boeke EA, Wolthusen RPF, Nyer M, Pedrelli P, Fava M, Holt DJ. Elevated Amygdala Activity in Young Adults With Familial Risk for Depression: A Potential Marker of Low Resilience. Biol Psychiatry Cogn Neurosci Neuroimaging. 2020 02; 5(2):194-202. PMID: 31948836.
    Citations:    Fields:    
  5. Ho NF, Holt DJ, Cheung M, Iglesias JE, Goh A, Wang M, Lim JKW, de Souza J, Poh JS, See YM, Adcock RA, Wood SJ, Chee MWL, Lee J, Zhou J. Correction: Progressive decline in hippocampal CA1 volume in individuals at ultra-high-risk for psychosis who do not remit: findings from the longitudinal youth at risk study. Neuropsychopharmacology. 2019 Nov; 44(12):2144. PMID: 31413353.
    Citations:    Fields:    
  6. Holt DJ. Deficient Hippocampal Habituation in Psychosis: A Manifestation of Hippocampal Overactivity? Biol Psychiatry Cogn Neurosci Neuroimaging. 2019 11; 4(11):938-939. PMID: 31699302.
    Citations:    Fields:    Translation:Humans
  7. Ge T, Chen CY, Doyle AE, Vettermann R, Tuominen LJ, Holt DJ, Sabuncu MR, Smoller JW. The Shared Genetic Basis of Educational Attainment and Cerebral Cortical Morphology. Cereb Cortex. 2019 07 22; 29(8):3471-3481. PMID: 30272126.
    Citations: 2     Fields:    Translation:Humans
  8. Gilbert TM, Zürcher NR, Catanese MC, Tseng CJ, Di Biase MA, Lyall AE, Hightower BG, Parmar AJ, Bhanot A, Wu CJ, Hibert ML, Kim M, Mahmood U, Stufflebeam SM, Schroeder FA, Wang C, Roffman JL, Holt DJ, Greve DN, Pasternak O, Kubicki M, Wey HY, Hooker JM. Neuroepigenetic signatures of age and sex in the living human brain. Nat Commun. 2019 07 03; 10(1):2945. PMID: 31270332.
    Citations: 3     Fields:    Translation:Humans
  9. Chen X, Fan X, Hu Y, Zuo C, Whitfield-Gabrieli S, Holt D, Gong Q, Yang Y, Pizzagalli DA, Du F, Ongur D. Regional GABA Concentrations Modulate Inter-network Resting-state Functional Connectivity. Cereb Cortex. 2019 04 01; 29(4):1607-1618. PMID: 29608677.
    Citations: 3     Fields:    Translation:Humans
  10. DeCross SN, Farabaugh AH, Holmes AJ, Ward M, Boeke EA, Wolthusen RPF, Coombs G, Nyer M, Fava M, Buckner RL, Holt DJ. Increased amygdala-visual cortex connectivity in youth with persecutory ideation. Psychol Med. 2020 01; 50(2):273-283. PMID: 30744715.
    Citations: 1     Fields:    
  11. Goff DC, Freudenreich O, Cather C, Holt D, Bello I, Diminich E, Tang Y, Ardekani BA, Worthington M, Zeng B, Wu R, Fan X, Li C, Troxel A, Wang J, Zhao J. Citalopram in first episode schizophrenia: The DECIFER trial. Schizophr Res. 2019 06; 208:331-337. PMID: 30709746.
    Citations:    Fields:    Translation:Humans
  12. Tuominen L, Boeke E, DeCross S, Wolthusen RP, Nasr S, Milad M, Vangel M, Tootell R, Holt D. The relationship of perceptual discrimination to neural mechanisms of fear generalization. Neuroimage. 2019 03; 188:445-455. PMID: 30572112.
    Citations: 1     Fields:    Translation:Humans
  13. Gilbert TM, Zürcher NR, Wu CJ, Bhanot A, Hightower BG, Kim M, Albrecht DS, Wey HY, Schroeder FA, Rodriguez-Thompson A, Morin TM, Hart KL, Pellegrini AM, Riley MM, Wang C, Stufflebeam SM, Haggarty SJ, Holt DJ, Loggia ML, Perlis RH, Brown HE, Roffman JL, Hooker JM. PET neuroimaging reveals histone deacetylase dysregulation in schizophrenia. J Clin Invest. 2019 01 02; 129(1):364-372. PMID: 30530989.
    Citations: 4     Fields:    Translation:HumansCTClinical Trials
  14. Shapero BG, Farabaugh A, Terechina O, DeCross S, Cheung JC, Fava M, Holt DJ. Understanding the effects of emotional reactivity on depression and suicidal thoughts and behaviors: Moderating effects of childhood adversity and resilience. J Affect Disord. 2019 02 15; 245:419-427. PMID: 30423470.
    Citations: 3     Fields:    Translation:Humans
  15. Blokland GAM, Del Re EC, Mesholam-Gately RI, Jovicich J, Trampush JW, Keshavan MS, DeLisi LE, Walters JTR, Turner JA, Malhotra AK, Lencz T, Shenton ME, Voineskos AN, Rujescu D, Giegling I, Kahn RS, Roffman JL, Holt DJ, Ehrlich S, Kikinis Z, Dazzan P, Murray RM, Di Forti M, Lee J, Sim K, Lam M, Wolthusen RPF, de Zwarte SMC, Walton E, Cosgrove D, Kelly S, Maleki N, Osiecki L, Picchioni MM, Bramon E, Russo M, David AS, Mondelli V, Reinders AATS, Falcone MA, Hartmann AM, Konte B, Morris DW, Gill M, Corvin AP, Cahn W, Ho NF, Liu JJ, Keefe RSE, Gollub RL, Manoach DS, Calhoun VD, Schulz SC, Sponheim SR, Goff DC, Buka SL, Cherkerzian S, Thermenos HW, Kubicki M, Nestor PG, Dickie EW, Vassos E, Ciufolini S, Reis Marques T, Crossley NA, Purcell SM, Smoller JW, van Haren NEM, Toulopoulou T, Donohoe G, Goldstein JM, Seidman LJ, McCarley RW, Petryshen TL. The Genetics of Endophenotypes of Neurofunction to Understand Schizophrenia (GENUS) consortium: A collaborative cognitive and neuroimaging genetics project. Schizophr Res. 2018 05; 195:306-317. PMID: 28982554.
    Citations: 2     Fields:    Translation:Humans
  16. Wolthusen RPF, Coombs G, Boeke EA, Ehrlich S, DeCross SN, Nasr S, Holt DJ. Correlation Between Levels of Delusional Beliefs and Perfusion of the Hippocampus and an Associated Network in a Non-Help-Seeking Population. Biol Psychiatry Cogn Neurosci Neuroimaging. 2018 02; 3(2):178-186. PMID: 29529413.
    Citations:    Fields:    Translation:Humans
  17. Ho NF, Holt DJ, Cheung M, Iglesias JE, Goh A, Wang M, Lim JK, de Souza J, Poh JS, See YM, Adcock AR, Wood SJ, Chee MW, Lee J, Zhou J. Progressive Decline in Hippocampal CA1 Volume in Individuals at Ultra-High-Risk for Psychosis Who Do Not Remit: Findings from the Longitudinal Youth at Risk Study. Neuropsychopharmacology. 2017 May; 42(6):1361-1370. PMID: 28079061.
    Citations: 12     Fields:    Translation:Humans
  18. Holt DJ. A Pathway to Understanding Emotional Dysfunction in Schizophrenia. JAMA Psychiatry. 2016 06 01; 73(6):555-6. PMID: 27145062.
    Citations:    Fields:    Translation:Humans
  19. Holt DJ, Boeke EA, Coombs G, DeCross SN, Cassidy BS, Stufflebeam S, Rauch SL, Tootell RBH. Corrigendum to abnormalities in personal space and parietal-frontal function in schizophrenia. Neuroimage Clin. 2016; 11:538. PMID: 27144121.
    Citations:    Fields:    
  20. Ho NF, Iglesias JE, Sum MY, Kuswanto CN, Sitoh YY, De Souza J, Hong Z, Fischl B, Roffman JL, Zhou J, Sim K, Holt DJ. Progression from selective to general involvement of hippocampal subfields in schizophrenia. Mol Psychiatry. 2017 01; 22(1):142-152. PMID: 26903271.
    Citations: 31     Fields:    Translation:Humans
  21. Brent BK, Rosso IM, Thermenos HW, Holt DJ, Faraone SV, Makris N, Tsuang MT, Seidman LJ. Alterations of lateral temporal cortical gray matter and facial memory as vulnerability indicators for schizophrenia: An MRI study in youth at familial high-risk for schizophrenia. Schizophr Res. 2016 Jan; 170(1):123-9. PMID: 26621001.
    Citations: 1     Fields:    Translation:Humans
  22. Rosenbaum BL, Bui E, Marin MF, Holt DJ, Lasko NB, Pitman RK, Orr SP, Milad MR. Reprint of: "Demographic factors predict magnitude of conditioned fear". Int J Psychophysiol. 2015 Dec; 98(3 Pt 2):606-11. PMID: 26608179.
    Citations:    Fields:    
  23. Wang D, Buckner RL, Fox MD, Holt DJ, Holmes AJ, Stoecklein S, Langs G, Pan R, Qian T, Li K, Baker JT, Stufflebeam SM, Wang K, Wang X, Hong B, Liu H. Parcellating cortical functional networks in individuals. Nat Neurosci. 2015 Dec; 18(12):1853-60. PMID: 26551545.
    Citations: 92     Fields:    Translation:Humans
  24. Maher S, Ekstrom T, Holt D, Ongur D, Chen Y. The Core Brain Region for Face Processing in Schizophrenia Lacks Face Selectivity. Schizophr Bull. 2016 May; 42(3):666-74. PMID: 26453911.
    Citations: 4     Fields:    Translation:Humans
  25. Wolthusen RP, Hass J, Walton E, Turner JA, Rössner V, Sponheim SR, Ho BC, Holt DJ, Gollub RL, Calhoun V, Ehrlich S. Genetic underpinnings of left superior temporal gyrus thickness in patients with schizophrenia. World J Biol Psychiatry. 2015 Aug 07; 1-11. PMID: 26249676.
    Citations: 3     Fields:    
  26. Holt DJ, Boeke EA, Coombs G, DeCross SN, Cassidy BS, Stufflebeam S, Rauch SL, Tootell RB. Abnormalities in personal space and parietal-frontal function in schizophrenia. Neuroimage Clin. 2015; 9:233-43. PMID: 26484048.
    Citations: 6     Fields:    Translation:Humans
  27. Rosenbaum BL, Bui E, Marin MF, Holt DJ, Lasko NB, Pitman RK, Orr SP, Milad MR. Demographic factors predict magnitude of conditioned fear. Int J Psychophysiol. 2015 Oct; 98(1):59-64. PMID: 26151498.
    Citations: 4     Fields:    Translation:Humans
  28. Mueller S, Wang D, Pan R, Holt DJ, Liu H. Abnormalities in hemispheric specialization of caudate nucleus connectivity in schizophrenia. JAMA Psychiatry. 2015 Jun; 72(6):552-60. PMID: 25830688.
    Citations: 16     Fields:    Translation:Humans
  29. Nyer M, Mischoulon D, Alpert JE, Holt DJ, Brill CD, Yeung A, Pedrelli P, Baer L, Dording C, Huz I, Fisher L, Fava M, Farabaugh A. College students with depressive symptoms with and without fatigue: Differences in functioning, suicidality, anxiety, and depressive severity. Ann Clin Psychiatry. 2015 May; 27(2):100-8. PMID: 25954936.
    Citations: 3     Fields:    Translation:Humans
  30. Farabaugh A, Fisher L, Nyer M, Holt D, Cohen M, Baer L, Shapero BG, Huz I, Cardoos A, Fava M, Alpert JE. Similar changes in cognitions following cognitive-behavioral therapy or escitalopram for major depressive disorder: Implications for mechanisms of change. Ann Clin Psychiatry. 2015 May; 27(2):118-26. PMID: 25954938.
    Citations: 3     Fields:    Translation:Humans
  31. Hass J, Walton E, Kirsten H, Turner J, Wolthusen R, Roessner V, Sponheim SR, Holt D, Gollub R, Calhoun VD, Ehrlich S. Complexin2 modulates working memory-related neural activity in patients with schizophrenia. Eur Arch Psychiatry Clin Neurosci. 2015 Mar; 265(2):137-45. PMID: 25297695.
    Citations: 4     Fields:    Translation:Humans
  32. Holt DJ, Boeke EA, Wolthusen RP, Nasr S, Milad MR, Tootell RB. A parametric study of fear generalization to faces and non-face objects: relationship to discrimination thresholds. Front Hum Neurosci. 2014; 8:624. PMID: 25249955.
    Citations: 4     
  33. Brent BK, Seidman LJ, Coombs G, Keshavan MS, Moran JM, Holt DJ. Neural responses during social reflection in relatives of schizophrenia patients: relationship to subclinical delusions. Schizophr Res. 2014 Aug; 157(1-3):292-8. PMID: 24951401.
    Citations: 4     Fields:    Translation:Humans
  34. Coombs G, Loggia ML, Greve DN, Holt DJ. Amygdala perfusion is predicted by its functional connectivity with the ventromedial prefrontal cortex and negative affect. PLoS One. 2014; 9(5):e97466. PMID: 24816735.
    Citations: 8     Fields:    Translation:Humans
  35. Holt DJ, Cassidy BS, Yue X, Rauch SL, Boeke EA, Nasr S, Tootell RB, Coombs G. Neural correlates of personal space intrusion. J Neurosci. 2014 Mar 19; 34(12):4123-34. PMID: 24647934.
    Citations: 16     Fields:    Translation:Humans
  36. Brent BK, Holt DJ, Keshavan MS, Seidman LJ, Fonagy P. Mentalization-based treatment for psychosis: linking an attachment-based model to the psychotherapy for impaired mental state understanding in people with psychotic disorders. Isr J Psychiatry Relat Sci. 2014; 51(1):17-24. PMID: 24858631.
    Citations: 7     Fields:    Translation:Humans
  37. Schneider CE, White T, Hass J, Geisler D, Wallace SR, Roessner V, Holt DJ, Calhoun VD, Gollub RL, Ehrlich S. Smoking status as a potential confounder in the study of brain structure in schizophrenia. J Psychiatr Res. 2014 Mar; 50:84-91. PMID: 24373929.
    Citations: 14     Fields:    Translation:HumansCells
  38. Pedrelli P, Nyer M, Holt D, Bakow BR, Fava M, Baer L, Cassiello C, Mulligan M, Cusin C, Farabaugh A. Correlates of irritability in college students with depressive symptoms. J Nerv Ment Dis. 2013 Nov; 201(11):953-8. PMID: 24177482.
    Citations: 5     Fields:    Translation:Humans
  39. Schwartz CE, Holt DJ, Rosenbaum JF. Methodological challenges of moving beyond DSM categories: transdiagnostic studies of frontolimbic connectivity changes in vulnerable individuals. Biol Psychiatry. 2013 Aug 15; 74(4):240-1. PMID: 23885753.
    Citations:    Fields:    Translation:Humans
  40. Brent BK, Seidman LJ, Thermenos HW, Holt DJ, Keshavan MS. Self-disturbances as a possible premorbid indicator of schizophrenia risk: a neurodevelopmental perspective. Schizophr Res. 2014 Jan; 152(1):73-80. PMID: 23932148.
    Citations: 12     Fields:    Translation:Humans
  41. Soskin DP, Holt DJ, Sacco GR, Fava M. Incentive salience: novel treatment strategies for major depression. CNS Spectr. 2013 Dec; 18(6):307-14. PMID: 23903027.
    Citations: 6     Fields:    Translation:HumansAnimals
  42. Nyer M, Farabaugh A, Fehling K, Soskin D, Holt D, Papakostas GI, Pedrelli P, Fava M, Pisoni A, Vitolo O, Mischoulon D. Relationship between sleep disturbance and depression, anxiety, and functioning in college students. Depress Anxiety. 2013 Sep; 30(9):873-80. PMID: 23681944.
    Citations: 22     Fields:    Translation:Humans
  43. Yue X, Nasr S, Devaney KJ, Holt DJ, Tootell RB. fMRI analysis of contrast polarity in face-selective cortex in humans and monkeys. Neuroimage. 2013 Aug 01; 76:57-69. PMID: 23518007.
    Citations: 4     Fields:    Translation:HumansAnimals
  44. Ho NF, Hooker JM, Sahay A, Holt DJ, Roffman JL. In vivo imaging of adult human hippocampal neurogenesis: progress, pitfalls and promise. Mol Psychiatry. 2013 Apr; 18(4):404-16. PMID: 23439487.
    Citations: 28     Fields:    Translation:HumansAnimals
  45. Nyer M, Holt DJ, Pedrelli P, Fava M, Ameral V, Cassiello CF, Nock MK, Ross M, Hutchinson D, Farabaugh A. Factors that distinguish college students with depressive symptoms with and without suicidal thoughts. Ann Clin Psychiatry. 2013 Feb; 25(1):41-9. PMID: 23376869.
    Citations: 12     Fields:    Translation:Humans
  46. Linnman C, Coombs G, Goff DC, Holt DJ. Lack of insula reactivity to aversive stimuli in schizophrenia. Schizophr Res. 2013 Jan; 143(1):150-7. PMID: 23201307.
    Citations: 9     Fields:    Translation:Humans
  47. Brent BK, Coombs G, Keshavan MS, Seidman LJ, Moran JM, Holt DJ. Subclinical delusional thinking predicts lateral temporal cortex responses during social reflection. Soc Cogn Affect Neurosci. 2014 Mar; 9(3):273-82. PMID: 23160817.
    Citations: 9     Fields:    Translation:HumansCTClinical Trials
  48. Holt DJ, Coombs G, Zeidan MA, Goff DC, Milad MR. Failure of neural responses to safety cues in schizophrenia. Arch Gen Psychiatry. 2012 Sep; 69(9):893-903. PMID: 22945619.
    Citations: 36     Fields:    Translation:Humans
  49. Farabaugh A, Bitran S, Nyer M, Holt DJ, Pedrelli P, Shyu I, Hollon SD, Zisook S, Baer L, Busse W, Petersen TJ, Pender M, Tucker DD, Fava M. Depression and suicidal ideation in college students. Psychopathology. 2012; 45(4):228-34. PMID: 22627683.
    Citations: 18     Fields:    Translation:HumansPHPublic Health
  50. Lebron-Milad K, Abbs B, Milad MR, Linnman C, Rougemount-Bücking A, Zeidan MA, Holt DJ, Goldstein JM. Sex differences in the neurobiology of fear conditioning and extinction: a preliminary fMRI study of shared sex differences with stress-arousal circuitry. Biol Mood Anxiety Disord. 2012 Apr 16; 2:7. PMID: 22738021.
    Citations: 32     
  51. Zeidan MA, Lebron-Milad K, Thompson-Hollands J, Im JJ, Dougherty DD, Holt DJ, Orr SP, Milad MR. Test-retest reliability during fear acquisition and fear extinction in humans. CNS Neurosci Ther. 2012 Apr; 18(4):313-7. PMID: 21592319.
    Citations: 13     Fields:    Translation:Humans
  52. Michael AM, King MD, Ehrlich S, Pearlson G, White T, Holt DJ, Andreasen NC, Sakoglu U, Ho BC, Schulz SC, Calhoun VD. A Data-Driven Investigation of Gray Matter-Function Correlations in Schizophrenia during a Working Memory Task. Front Hum Neurosci. 2011; 5:71. PMID: 21886614.
    Citations: 11     
  53. Ehrlich S, Yendiki A, Greve DN, Manoach DS, Ho BC, White T, Schulz SC, Goff DC, Gollub RL, Holt DJ. Striatal function in relation to negative symptoms in schizophrenia. Psychol Med. 2012 Feb; 42(2):267-82. PMID: 21733291.
    Citations: 15     Fields:    Translation:Humans
  54. Holt DJ, Cassidy BS, Andrews-Hanna JR, Lee SM, Coombs G, Goff DC, Gabrieli JD, Moran JM. An anterior-to-posterior shift in midline cortical activity in schizophrenia during self-reflection. Biol Psychiatry. 2011 Mar 01; 69(5):415-23. PMID: 21144498.
    Citations: 51     Fields:    
  55. Yeo BT, Sabuncu MR, Vercauteren T, Holt DJ, Amunts K, Zilles K, Golland P, Fischl B. Learning task-optimal registration cost functions for localizing cytoarchitecture and function in the cerebral cortex. IEEE Trans Med Imaging. 2010 Jul; 29(7):1424-41. PMID: 20529736.
    Citations: 23     Fields:    Translation:Humans
  56. Yue X, Cassidy BS, Devaney KJ, Holt DJ, Tootell RB. Lower-level stimulus features strongly influence responses in the fusiform face area. Cereb Cortex. 2011 Jan; 21(1):35-47. PMID: 20375074.
    Citations: 35     Fields:    Translation:Humans
  57. Ehrlich S, Morrow EM, Roffman JL, Wallace SR, Naylor M, Bockholt HJ, Lundquist A, Yendiki A, Ho BC, White T, Manoach DS, Clark VP, Calhoun VD, Gollub RL, Holt DJ. The COMT Val108/158Met polymorphism and medial temporal lobe volumetry in patients with schizophrenia and healthy adults. Neuroimage. 2010 Nov 15; 53(3):992-1000. PMID: 20026221.
    Citations: 32     Fields:    Translation:Humans
  58. Holt DJ, Lynn SK, Kuperberg GR. Neurophysiological correlates of comprehending emotional meaning in context. J Cogn Neurosci. 2009 Nov; 21(11):2245-62. PMID: 18855550.
    Citations: 27     Fields:    Translation:Humans
  59. Gasic GP, Smoller JW, Perlis RH, Sun M, Lee S, Kim BW, Lee MJ, Holt DJ, Blood AJ, Makris N, Kennedy DK, Hoge RD, Calhoun J, Fava M, Gusella JF, Breiter HC. BDNF, relative preference, and reward circuitry responses to emotional communication. . 2009 Sep 05; 150B(6):762-81. PMID: 19388013.
    Citations: 29     Translation:Humans
  60. Holt DJ, Lakshmanan B, Freudenreich O, Goff DC, Rauch SL, Kuperberg GR. Dysfunction of a cortical midline network during emotional appraisals in schizophrenia. Schizophr Bull. 2011 Jan; 37(1):164-76. PMID: 19605517.
    Citations: 23     Fields:    Translation:Humans
  61. Kuperberg GR, Kreher DA, Swain A, Goff DC, Holt DJ. Selective emotional processing deficits to social vignettes in schizophrenia: an ERP study. Schizophr Bull. 2011 Jan; 37(1):148-63. PMID: 19564165.
    Citations: 7     Fields:    Translation:Humans
  62. Norton D, McBain R, Holt DJ, Ongur D, Chen Y. Association of impaired facial affect recognition with basic facial and visual processing deficits in schizophrenia. Biol Psychiatry. 2009 Jun 15; 65(12):1094-8. PMID: 19268917.
    Citations: 36     Fields:    Translation:Humans
  63. Holt DJ, Lebron-Milad K, Milad MR, Rauch SL, Pitman RK, Orr SP, Cassidy BS, Walsh JP, Goff DC. Extinction memory is impaired in schizophrenia. Biol Psychiatry. 2009 Mar 15; 65(6):455-63. PMID: 18986648.
    Citations: 74     Fields:    Translation:Humans
  64. Perlis RH, Holt DJ, Smoller JW, Blood AJ, Lee S, Kim BW, Lee MJ, Sun M, Makris N, Kennedy DK, Rooney K, Dougherty DD, Hoge R, Rosenbaum JF, Fava M, Gusella J, Gasic GP, Breiter HC. Association of a polymorphism near CREB1 with differential aversion processing in the insula of healthy participants. Arch Gen Psychiatry. 2008 Aug; 65(8):882-92. PMID: 18678793.
    Citations: 14     Fields:    Translation:Humans
  65. Freudenreich O, Holt DJ, Cather C, Goff DC. The evaluation and management of patients with first-episode schizophrenia: a selective, clinical review of diagnosis, treatment, and prognosis. Harv Rev Psychiatry. 2007 Sep-Oct; 15(5):189-211. PMID: 17924256.
    Citations: 5     Fields:    Translation:Humans
  66. Kuperberg GR, Deckersbach T, Holt DJ, Goff D, West WC. Increased temporal and prefrontal activity in response to semantic associations in schizophrenia. Arch Gen Psychiatry. 2007 Feb; 64(2):138-51. PMID: 17283282.
    Citations: 38     Fields:    Translation:Humans
  67. Freudenreich O, Cather C, Holt D. Stimulant misuse in college for "pseudo-attention deficit disorder" during schizophrenia prodrome. Am J Psychiatry. 2006 Nov; 163(11):2019. PMID: 17074965.
    Citations:    Fields:    Translation:Humans
  68. Holt DJ, Titone D, Long LS, Goff DC, Cather C, Rauch SL, Judge A, Kuperberg GR. The misattribution of salience in delusional patients with schizophrenia. Schizophr Res. 2006 Apr; 83(2-3):247-56. PMID: 16540291.
    Citations: 24     Fields:    Translation:Humans
  69. Holt DJ, Kunkel L, Weiss AP, Goff DC, Wright CI, Shin LM, Rauch SL, Hootnick J, Heckers S. Increased medial temporal lobe activation during the passive viewing of emotional and neutral facial expressions in schizophrenia. Schizophr Res. 2006 Feb 28; 82(2-3):153-62. PMID: 16377154.
    Citations: 83     Fields:    Translation:Humans
  70. Holt DJ, Bachus SE, Hyde TM, Wittie M, Herman MM, Vangel M, Saper CB, Kleinman JE. Reduced density of cholinergic interneurons in the ventral striatum in schizophrenia: an in situ hybridization study. Biol Psychiatry. 2005 Sep 01; 58(5):408-16. PMID: 16023618.
    Citations: 25     Fields:    Translation:HumansCells
  71. Holt DJ, Weiss AP, Rauch SL, Wright CI, Zalesak M, Goff DC, Ditman T, Welsh RC, Heckers S. Sustained activation of the hippocampus in response to fearful faces in schizophrenia. Biol Psychiatry. 2005 May 01; 57(9):1011-9. PMID: 15860342.
    Citations: 50     Fields:    Translation:Humans
  72. Holt DJ, Phillips KA, Shapiro ER, Becker AE. "My Face Is My Fate": biological and psychosocial approaches to the treatment of a woman with obsessions and delusions. Harv Rev Psychiatry. 2003 May-Jun; 11(3):142-54. PMID: 12893504.
    Citations: 1     Fields:    Translation:Humans
  73. Holt DJ, Herman MM, Hyde TM, Kleinman JE, Sinton CM, German DC, Hersh LB, Graybiel AM, Saper CB. Evidence for a deficit in cholinergic interneurons in the striatum in schizophrenia. Neuroscience. 1999; 94(1):21-31. PMID: 10613493.
    Citations: 32     Fields:    Translation:HumansCells
  74. Holt DJ, Graybiel AM, Saper CB. Neurochemical architecture of the human striatum. J Comp Neurol. 1997 Jul 21; 384(1):1-25. PMID: 9214537.
    Citations: 46     Fields:    Translation:HumansCells
  75. Holt DJ, Hersh LB, Saper CB. Cholinergic innervation in the human striatum: a three-compartment model. Neuroscience. 1996 Sep; 74(1):67-87. PMID: 8843078.
    Citations: 12     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.