Harvard Catalyst Profiles

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Denise L. Faustman, M.D., Ph.D.

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Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. P30DK057521 (FLOREZ, JOSE CARLOS) Jun 1, 2000 - Mar 31, 2021
    NIH
    Boston Area Diabetes Endocrinology Research Center
    Role: Co-Principal Investigator
  2. R01HD032460 (FAUSTMAN, DENISE L) Apr 10, 1997 - Mar 31, 2001
    NIH
    BASIC AND CLINICAL INTERVENTION IN OVARIAN FAILURE
    Role: Principal Investigator
  3. R03DE011023 (FAUSTMAN, DENISE L) Apr 1, 1994 - Mar 31, 1996
    NIH
    GENETIC SCREENING OF SJOGRENS FOR MUTATION IN TAP-1/2
    Role: Principal Investigator
  4. R01DE011151 (FAUSTMAN, DENISE L) Mar 1, 1994 - Feb 28, 1999
    NIH
    EXPLORATION FOR A NEW PATHOGENESIS OF SJOGRENS SYNDROME
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Dias HF, Mochizuki Y, Kühtreiber WM, Takahashi H, Zheng H, Faustman DL. Bacille Calmette Guerin (BCG) and prevention of types 1 and 2 diabetes: Results of two observational studies. PLoS One. 2023; 18(1):e0276423. PMID: 36662841; PMCID: PMC9858877.
    Citations:    Fields:    Translation:Humans
  2. Takahashi H, Kühtreiber WM, Keefe RC, Lee AH, Aristarkhova A, Dias HF, Ng N, Nelson KJ, Bien S, Scheffey D, Faustman DL. BCG vaccinations drive epigenetic changes to the human T cell receptor: Restored expression in type 1 diabetes. Sci Adv. 2022 Nov 18; 8(46):eabq7240. PMID: 36383663; PMCID: PMC9668301.
    Citations:    Fields:    
  3. He T, Chen Y, Islam MS, Chou CK, Liu J, Faustman DL, Oppenheim JJ, Chen X. TNFR2 antagonistic antibody induces the death of tumor infiltrating CD4+Foxp3+ regulatory T cells. Cell Oncol (Dordr). 2023 Feb; 46(1):167-177. PMID: 36369606.
    Citations: 2     Fields:    Translation:AnimalsCells
  4. Faustman DL, Lee A, Hostetter ER, Aristarkhova A, Ng NC, Shpilsky GF, Tran L, Wolfe G, Takahashi H, Dias HF, Braley J, Zheng H, Schoenfeld DA, Kühtreiber WM. Multiple BCG vaccinations for the prevention of COVID-19 and other infectious diseases in type 1 diabetes. Cell Rep Med. 2022 09 20; 3(9):100728. PMID: 36027906; PMCID: PMC9376308.
    Citations: 5     Fields:    Translation:HumansCellsPHPublic HealthCTClinical Trials
  5. Takahashi H, Yoshimatsu G, Faustman DL. The Roles of TNFR2 Signaling in Cancer Cells and the Tumor Microenvironment and the Potency of TNFR2 Targeted Therapy. Cells. 2022 06 17; 11(12). PMID: 35741080; PMCID: PMC9222015.
    Citations:    Fields:    Translation:AnimalsCells
  6. Vanamee ÉS, Lippner G, Faustman DL. Signal Amplification in Highly Ordered Networks Is Driven by Geometry. Cells. 2022 01 13; 11(2). PMID: 35053388; PMCID: PMC8773832.
    Citations:    Fields:    Translation:HumansAnimalsCells
  7. Jiang M, Liu J, Tross D, Li P, Chen F, Alam MM, Faustman DL, Oppenheim JJ, Chen X. A TNFR2 antibody by countering immunosuppression cooperates with HMGN1 and R848 immune stimulants to inhibit murine colon cancer. Int Immunopharmacol. 2021 Dec; 101(Pt A):108345. PMID: 34794079; PMCID: PMC8665148.
    Citations: 5     Fields:    Translation:AnimalsCells
  8. Angelidou A, Pittet LF, Faustman D, Curtis N, Levy O. BCG vaccine's off-target effects on allergic, inflammatory, and autoimmune diseases: Worth another shot? J Allergy Clin Immunol. 2022 01; 149(1):51-54. PMID: 34673049.
    Citations: 1     Fields:    Translation:Humans
  9. Shpilsky GF, Takahashi H, Aristarkhova A, Weil M, Ng N, Nelson KJ, Lee A, Zheng H, Kühtreiber WM, Faustman DL. Bacillus Calmette-Guerin 's beneficial impact on glucose metabolism: evidence for broad based applications. iScience. 2021 Oct 22; 24(10):103150. PMID: 34646988.
    Citations:    
  10. Keefe RC, Takahashi H, Tran L, Nelson K, Ng N, Kühtreiber WM, Faustman DL. BCG therapy is associated with long-term, durable induction of Treg signature genes by epigenetic modulation. Sci Rep. 2021 07 22; 11(1):14933. PMID: 34294806.
    Citations: 1     Fields:    Translation:HumansCells
  11. Dias HF, Kühtreiber WM, Nelson KJ, Ng NC, Zheng H, Faustman DL. Epigenetic changes related to glucose metabolism in type 1 diabetes after BCG vaccinations: A vital role for KDM2B. Vaccine. 2022 03 08; 40(11):1540-1554. PMID: 33933315.
    Citations: 1     Fields:    Translation:HumansCellsPHPublic Health
  12. Torrey H, Kühtreiber WM, Okubo Y, Tran L, Case K, Zheng H, Vanamee E, Faustman DL. A novel TNFR2 agonist antibody expands highly potent regulatory T cells. Sci Signal. 2020 12 08; 13(661). PMID: 33293464.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  13. Adetunji SA, Faustman DL, Adams LG, Garcia-Gonzalez DG, Hensel ME, Khalaf OH, Arenas-Gamboa AM. Brucella abortus and Pregnancy in Mice: Impact of Chronic Infection on Fertility and the Role of Regulatory T Cells in Tissue Colonization. Infect Immun. 2020 09 18; 88(10). PMID: 32690635; PMCID: PMC7504963.
    Citations: 1     Fields:    Translation:AnimalsCells
  14. Rivero-Calle I, Gómez-Rial J, Bont L, Gessner BD, Kohn M, Dagan R, Payne DC, Bruni L, Pollard AJ, García-Sastre A, Faustman DL, Osterhaus A, Butler R, Giménez Sánchez F, Álvarez F, Kaforou M, Bello X, Martinón-Torres F. TIPICO X: report of the 10th interactive infectious disease workshop on infectious diseases and vaccines. Hum Vaccin Immunother. 2021 03 04; 17(3):759-772. PMID: 32755474.
    Citations:    Fields:    Translation:HumansAnimalsCellsPHPublic Health
  15. Case K, Tran L, Yang M, Zheng H, Kuhtreiber WM, Faustman DL. TNFR2 blockade alone or in combination with PD-1 blockade shows therapeutic efficacy in murine cancer models. J Leukoc Biol. 2020 06; 107(6):981-991. PMID: 32449229.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  16. Kühtreiber WM, Takahashi H, Keefe RC, Song Y, Tran L, Luck TG, Shpilsky G, Moore L, Sinton SM, Graham JC, Faustman DL. BCG Vaccinations Upregulate Myc, a Central Switch for Improved Glucose Metabolism in Diabetes. iScience. 2020 May 22; 23(5):101085. PMID: 32380424.
    Citations: 2     
  17. Yang M, Tran L, Torrey H, Song Y, Perkins H, Case K, Zheng H, Takahashi H, Kuhtreiber WM, Faustman DL. Optimizing TNFR2 antagonism for immunotherapy with tumor microenvironment specificity. J Leukoc Biol. 2020 06; 107(6):971-980. PMID: 32202358.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  18. Vanamee ÉS, Faustman DL. On the TRAIL of Better Therapies: Understanding TNFRSF Structure-Function. Cells. 2020 03 20; 9(3). PMID: 32245106.
    Citations: 8     Fields:    Translation:HumansCells
  19. Faustman DL. Benefits of BCG-induced metabolic switch from oxidative phosphorylation to aerobic glycolysis in autoimmune and nervous system diseases. J Intern Med. 2020 12; 288(6):641-650. PMID: 32107806.
    Citations: 9     Fields:    Translation:HumansCells
  20. Kühtreiber WM, Faustman DL. BCG Therapy for Type 1 Diabetes: Restoration of Balanced Immunity and Metabolism. Trends Endocrinol Metab. 2019 02; 30(2):80-92. PMID: 30600132.
    Citations: 17     Fields:    Translation:Humans
  21. Atretkhany KN, Mufazalov IA, Dunst J, Kuchmiy A, Gogoleva VS, Andruszewski D, Drutskaya MS, Faustman DL, Schwabenland M, Prinz M, Kruglov AA, Waisman A, Nedospasov SA. Intrinsic TNFR2 signaling in T regulatory cells provides protection in CNS autoimmunity. Proc Natl Acad Sci U S A. 2018 12 18; 115(51):13051-13056. PMID: 30498033; PMCID: PMC6304938.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  22. Ristori G, Faustman D, Matarese G, Romano S, Salvetti M. Bridging the gap between vaccination with Bacille Calmette-Guérin (BCG) and immunological tolerance: the cases of type 1 diabetes and multiple sclerosis. Curr Opin Immunol. 2018 12; 55:89-96. PMID: 30447407.
    Citations: 11     Fields:    Translation:HumansPHPublic Health
  23. Torrey H, Khodadoust M, Tran L, Baum D, Defusco A, Kim YH, Faustman DL. Targeted killing of TNFR2-expressing tumor cells and Tregs by TNFR2 antagonistic antibodies in advanced Sézary syndrome. Leukemia. 2019 05; 33(5):1206-1218. PMID: 30356161; PMCID: PMC6756055.
    Citations: 24     Fields:    Translation:HumansCells
  24. Kühtreiber WM, Tran L, Kim T, Dybala M, Nguyen B, Plager S, Huang D, Janes S, Defusco A, Baum D, Zheng H, Faustman DL. Long-term reduction in hyperglycemia in advanced type 1 diabetes: the value of induced aerobic glycolysis with BCG vaccinations. NPJ Vaccines. 2018; 3:23. PMID: 29951281; PMCID: PMC6013479.
    Citations: 37     
  25. Vanamee ÉS, Faustman DL. Structural principles of tumor necrosis factor superfamily signaling. Sci Signal. 2018 01 02; 11(511). PMID: 29295955.
    Citations: 78     Fields:    Translation:HumansAnimalsCells
  26. Vanamee ÉS, Faustman DL. TNFR2: A Novel Target for Cancer Immunotherapy. Trends Mol Med. 2017 11; 23(11):1037-1046. PMID: 29032004.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  27. Faustman DL. TNF, TNF inducers, and TNFR2 agonists: A new path to type 1 diabetes treatment. Diabetes Metab Res Rev. 2018 01; 34(1). PMID: 28843039.
    Citations: 16     Fields:    Translation:HumansCells
  28. Torrey H, Butterworth J, Mera T, Okubo Y, Wang L, Baum D, Defusco A, Plager S, Warden S, Huang D, Vanamee E, Foster R, Faustman DL. Targeting TNFR2 with antagonistic antibodies inhibits proliferation of ovarian cancer cells and tumor-associated Tregs. Sci Signal. 2017 01 17; 10(462). PMID: 28096513.
    Citations: 76     Fields:    Translation:HumansCells
  29. Okubo Y, Torrey H, Butterworth J, Zheng H, Faustman DL. Treg activation defect in type 1 diabetes: correction with TNFR2 agonism. Clin Transl Immunology. 2016 Jan; 5(1):e56. PMID: 26900470; PMCID: PMC4735064.
    Citations: 41     
  30. Kuhtreiber WM, Washer SL, Hsu E, Zhao M, Reinhold P, Burger D, Zheng H, Faustman DL. Low levels of C-peptide have clinical significance for established Type 1 diabetes. Diabet Med. 2015 Oct; 32(10):1346-53. PMID: 26172028; PMCID: PMC4578991.
    Citations: 39     Fields:    Translation:Humans
  31. Ban L, Kuhtreiber W, Butterworth J, Okubo Y, Vanamee ÉS, Faustman DL. Strategic internal covalent cross-linking of TNF produces a stable TNF trimer with improved TNFR2 signaling. Mol Cell Ther. 2015; 3:7. PMID: 26266038; PMCID: PMC4531505.
    Citations: 8     
  32. Mera T, Faustman DL. Removal of donor human leukocyte antigen class I proteins with papain: translation for possible whole organ practices. Transplantation. 2015 Apr; 99(4):724-30. PMID: 25340603.
    Citations: 1     Fields:    Translation:HumansCells
  33. Faustman DL, Vivino FB, Carsons SE. Treatment of primary Sjögren syndrome with rituximab. Ann Intern Med. 2014 Sep 02; 161(5):376-7. PMID: 25178574.
    Citations: 3     Fields:    Translation:Humans
  34. Khalili S, Faustman DL, Liu Y, Sumita Y, Blank D, Peterson A, Kodama S, Tran SD. Treatment for salivary gland hypofunction at both initial and advanced stages of Sjögren-like disease: a comparative study of bone marrow therapy versus spleen cell therapy with a 1-year monitoring period. Cytotherapy. 2014 Mar; 16(3):412-23. PMID: 24411591.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  35. Faustman DL, Davis M. TNF Receptor 2 and Disease: Autoimmunity and Regenerative Medicine. Front Immunol. 2013 Dec 23; 4:478. PMID: 24391650.
    Citations: 71     Fields:    
  36. Okubo Y, Mera T, Wang L, Faustman DL. Homogeneous expansion of human T-regulatory cells via tumor necrosis factor receptor 2. Sci Rep. 2013 Nov 06; 3:3153. PMID: 24193319.
    Citations: 84     Fields:    Translation:HumansAnimalsCells
  37. Faustman DL. Why were we wrong for so long? The pancreas of type 1 diabetic patients commonly functions for decades. Diabetologia. 2014 Jan; 57(1):1-3. PMID: 24190583.
    Citations: 8     Fields:    Translation:HumansCells
  38. Enger TB, Samad-Zadeh A, Bouchie MP, Skarstein K, Galtung HK, Mera T, Walker J, Menko AS, Varelas X, Faustman DL, Jensen JL, Kukuruzinska MA. The Hippo signaling pathway is required for salivary gland development and its dysregulation is associated with Sjogren's syndrome. Lab Invest. 2013 Nov; 93(11):1203-18. PMID: 24080911; PMCID: PMC3864807.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  39. Martinez-Gamboa L, Lesemann K, Kuckelkorn U, Scheffler S, Ghannam K, Hahne M, Gaber-Elsner T, Egerer K, Naumann L, Buttgereit F, Dörner T, Kloetzel PM, Burmester GR, Faustman DL, Feist E. Gene expression of catalytic proteasome subunits and resistance toward proteasome inhibition of B lymphocytes from patients with primary sjogren syndrome. J Rheumatol. 2013 May; 40(5):663-73. PMID: 23504381.
    Citations: 6     Fields:    Translation:HumansCells
  40. Faustman DL. EBV infection and anti-CD3 treatment for Type 1 diabetes: bad cop, good cop? Expert Rev Clin Immunol. 2013 Feb; 9(2):95-7. PMID: 23390937; PMCID: PMC4078994.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  41. Faustman DL, Wang L, Okubo Y, Burger D, Ban L, Man G, Zheng H, Schoenfeld D, Pompei R, Avruch J, Nathan DM. Proof-of-concept, randomized, controlled clinical trial of Bacillus-Calmette-Guerin for treatment of long-term type 1 diabetes. PLoS One. 2012; 7(8):e41756. PMID: 22905105.
    Citations: 45     Fields:    Translation:HumansCells
  42. Wang L, Lovejoy NF, Faustman DL. Persistence of prolonged C-peptide production in type 1 diabetes as measured with an ultrasensitive C-peptide assay. Diabetes Care. 2012 Mar; 35(3):465-70. PMID: 22355018.
    Citations: 79     Fields:    Translation:Humans
  43. Burger DE, Wang L, Ban L, Okubo Y, Kühtreiber WM, Leichliter AK, Faustman DL. Novel automated blood separations validate whole cell biomarkers. PLoS One. 2011; 6(7):e22430. PMID: 21799852.
    Citations: 2     Fields:    Translation:HumansCells
  44. Faustman DL, Davis M. Stem cells in the spleen: therapeutic potential for Sjogren's syndrome, type I diabetes, and other disorders. Int J Biochem Cell Biol. 2010 Oct; 42(10):1576-9. PMID: 20601088.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  45. Faustman D, Davis M. TNF receptor 2 pathway: drug target for autoimmune diseases. Nat Rev Drug Discov. 2010 Jun; 9(6):482-93. PMID: 20489699.
    Citations: 187     Fields:    Translation:HumansCells
  46. Dieguez-Acuña F, Kodama S, Okubo Y, Paz AC, Gygi SP, Faustman DL. Proteomics identifies multipotent and low oncogenic risk stem cells of the spleen. Int J Biochem Cell Biol. 2010 Oct; 42(10):1651-60. PMID: 20005973; PMCID: PMC2891339.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  47. Morawietz L, Martinez-Gamboa L, Scheffler S, Hausdorf G, Dankof A, Kuckelkorn U, Doerner T, Egerer K, Burmester GR, Faustman DL, Feist E. Expression of proteasomal immunosubunit beta1i is dysregulated in inflammatory infiltrates of minor salivary glands in Sjogren's syndrome. J Rheumatol. 2009 Dec; 36(12):2694-703. PMID: 19833746.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  48. Faustman DL, Davis M. The primacy of CD8 T lymphocytes in type 1 diabetes and implications for therapies. J Mol Med (Berl). 2009 Dec; 87(12):1173-8. PMID: 19693476.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  49. Faustman DL. Immunotherapy on trial for new-onset type 1 diabetes. N Engl J Med. 2008 Oct 30; 359(18):1956-8. PMID: 18843119.
    Citations: 3     Fields:    Translation:Humans
  50. Ban L, Zhang J, Wang L, Kuhtreiber W, Burger D, Faustman DL. Selective death of autoreactive T cells in human diabetes by TNF or TNF receptor 2 agonism. Proc Natl Acad Sci U S A. 2008 Sep 09; 105(36):13644-9. PMID: 18755894.
    Citations: 41     Fields:    Translation:HumansCells
  51. Lonyai A, Kodama S, Burger D, Faustman DL. Fetal Hox11 expression patterns predict defective target organs: a novel link between developmental biology and autoimmunity. Immunol Cell Biol. 2008 May-Jun; 86(4):301-9. PMID: 18301381.
    Citations: 8     Fields:    Translation:HumansAnimals
  52. Lonyai A, Kodama S, Burger D, Davis M, Faustman DL. The promise of Hox11+ stem cells of the spleen for treating autoimmune diseases. Horm Metab Res. 2008 Feb; 40(2):137-46. PMID: 18283632.
    Citations: 9     Fields:    Translation:HumansAnimals
  53. Dieguez-Acuna FJ, Gygi SP, Davis M, Faustman DL. Splenectomy: a new treatment option for ALL tumors expressing Hox-11 and a means to test the stem cell hypothesis of cancer in humans. Leukemia. 2007 Oct; 21(10):2192-4. PMID: 17713543.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  54. Faustman DL. Permanent reversal of diabetes in NOD mice. Science. 2007 Jul 13; 317(5835):196. PMID: 17626866.
    Citations:    Fields:    Translation:Animals
  55. Faustman DL. Reversal of type 1 diabetes in mice. N Engl J Med. 2007 01 18; 356(3):311-2. PMID: 17229964.
    Citations:    Fields:    Translation:Animals
  56. Tran SD, Kodama S, Lodde BM, Szalayova I, Key S, Khalili S, Faustman DL, Mezey E. Reversal of Sjogren's-like syndrome in non-obese diabetic mice. Ann Rheum Dis. 2007 Jun; 66(6):812-4. PMID: 17179174; PMCID: PMC1954678.
    Citations: 16     Fields:    Translation:Animals
  57. Dale E, Davis M, Faustman DL. A role for transcription factor NF-kappaB in autoimmunity: possible interactions of genes, sex, and the immune response. Adv Physiol Educ. 2006 Dec; 30(4):152-8. PMID: 17108242.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  58. Faustman DL, Tran SD, Kodama S, Lodde BM, Szalayova I, Key S, Toth ZE, Mezey E. Comment on papers by Chong et al., Nishio et al., and Suri et al. on diabetes reversal in NOD mice. Science. 2006 Nov 24; 314(5803):1243; author reply 1243. PMID: 17124308.
    Citations: 5     Fields:    Translation:AnimalsCells
  59. Faustman D. Search for cure moves forward despite controversy. Interview by Ho Spencer. Nephrol News Issues. 2006 Jun; 20(7):24, 26. PMID: 16764140.
    Citations:    Fields:    Translation:HumansAnimals
  60. Faustman DL. Regenerative medicine: Stem cell research turns to the spleen. Discov Med. 2005 Oct; 5(29):447-9. PMID: 20704840.
    Citations: 2     Fields:    
  61. Kühtreiber WM, Kodama S, Burger DE, Dale EA, Faustman DL. Methods to characterize lymphoid apoptosis in a murine model of autoreactivity. J Immunol Methods. 2005 Nov 30; 306(1-2):137-50. PMID: 16242708.
    Citations: 3     Fields:    Translation:AnimalsCells
  62. Kodama S, Davis M, Faustman DL. The therapeutic potential of tumor necrosis factor for autoimmune disease: a mechanistically based hypothesis. Cell Mol Life Sci. 2005 Aug; 62(16):1850-62. PMID: 15968469.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  63. Dieguez-Acuna FJ, Gerber SA, Kodama S, Elias JE, Beausoleil SA, Faustman D, Gygi SP. Characterization of mouse spleen cells by subtractive proteomics. Mol Cell Proteomics. 2005 Oct; 4(10):1459-70. PMID: 16037072.
    Citations: 23     Fields:    Translation:Animals
  64. Kodama S, Davis M, Faustman DL. Regenerative medicine: a radical reappraisal of the spleen. Trends Mol Med. 2005 Jun; 11(6):271-6. PMID: 15949768.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  65. Kodama S, Davis M, Faustman DL. Diabetes and stem cell researchers turn to the lowly spleen. Sci Aging Knowledge Environ. 2005 Jan 19; 2005(3):pe2. PMID: 15659719.
    Citations: 11     Fields:    Translation:AnimalsCells
  66. Abraham EJ, Kodama S, Lin JC, Ubeda M, Faustman DL, Habener JF. Human pancreatic islet-derived progenitor cell engraftment in immunocompetent mice. Am J Pathol. 2004 Mar; 164(3):817-30. PMID: 14982836; PMCID: PMC1613272.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  67. Kodama S, Faustman DL. Routes to regenerating islet cells: stem cells and other biological therapies for type 1 diabetes. Pediatr Diabetes. 2004; 5 Suppl 2:38-44. PMID: 15601373.
    Citations: 5     Fields:    Translation:Humans
  68. Kühtreiber WM, Hayashi T, Dale EA, Faustman DL. Central role of defective apoptosis in autoimmunity. J Mol Endocrinol. 2003 Dec; 31(3):373-99. PMID: 14664701.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  69. Kodama S, Kühtreiber W, Fujimura S, Dale EA, Faustman DL. Islet regeneration during the reversal of autoimmune diabetes in NOD mice. Science. 2003 Nov 14; 302(5648):1223-7. PMID: 14615542.
    Citations: 105     Fields:    Translation:AnimalsCells
  70. Yan G, Shi L, Penfornis A, Faustman DL. Impaired processing and presentation by MHC class II proteins in human diabetic cells. J Immunol. 2003 Jan 01; 170(1):620-7. PMID: 12496451.
    Citations: 4     Fields:    Translation:HumansCells
  71. Hayashi T, Faustman DL. Role of defective apoptosis in type 1 diabetes and other autoimmune diseases. Recent Prog Horm Res. 2003; 58:131-53. PMID: 12795417.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  72. Penfornis A, Yan G, Shi L, Faustman DL. Polymorphisms of human TAP2 detected by denaturing gradient gel electrophoresis. Hum Immunol. 2003 Jan; 64(1):156-67. PMID: 12507827.
    Citations: 1     Fields:    Translation:Humans
  73. Faustman DL, Pedersen RL, Kim SK, Lemischka IR, McKay RD. Cells for repair: breakout session summary. Ann N Y Acad Sci. 2002 Jun; 961:45-7. PMID: 12081862.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  74. Faustman DL. Reversal of established autoimmune diabetes by in situ beta-cell regeneration. Ann N Y Acad Sci. 2002 Jun; 961:40. PMID: 12081859.
    Citations:    Fields:    Translation:AnimalsCells
  75. Hayashi T, Faustman DL. Development of spontaneous uterine tumors in low molecular mass polypeptide-2 knockout mice. Cancer Res. 2002 Jan 01; 62(1):24-7. PMID: 11782352.
    Citations: 20     Fields:    Translation:AnimalsCells
  76. Penfornis A, Tuomilehto-Wolf E, Faustman DL, Hitman GA. Analysis of TAP2 polymorphisms in Finnish individuals with type I diabetes. Hum Immunol. 2002 Jan; 63(1):61-70. PMID: 11916171.
    Citations: 5     Fields:    Translation:HumansCells
  77. Hayashi T, Faustman DL. Selected contribution: Association of gender-related LMP2 inactivation with autoimmune pathogenesis. J Appl Physiol (1985). 2001 Dec; 91(6):2804-15. PMID: 11717249.
    Citations: 8     Fields:    Translation:AnimalsCells
  78. Lee ML, Schoenfeld D, Wang X, Penfornis A, Faustman D. Bayesian analysis of case control polygenic etiology studies with missing data. Biostatistics. 2001 Sep; 2(3):309-22. PMID: 12933541.
    Citations:    Fields:    
  79. Ryu S, Kodama S, Ryu K, Schoenfeld DA, Faustman DL. Reversal of established autoimmune diabetes by restoration of endogenous beta cell function. J Clin Invest. 2001 Jul; 108(1):63-72. PMID: 11435458; PMCID: PMC209340.
    Citations: 55     Fields:    Translation:HumansAnimalsCells
  80. Hayashi T, Faustman DL. Implications of altered apoptosis in diabetes mellitus and autoimmune disease. Apoptosis. 2001 Feb-Apr; 6(1-2):31-45. PMID: 11321039.
    Citations: 6     Fields:    Translation:HumansAnimals
  81. Hayashi T, Kodama S, Faustman DL. Reply to 'LMP2 expression and proteasome activity in NOD mice' Nat Med. 2000 Oct; 6(10):1065-6. PMID: 11017113.
    Citations: 13     Fields:    
  82. Hayashi T, Faustman D. The role of the proteasome in autoimmunity. Diabetes Metab Res Rev. 2000 Sep-Oct; 16(5):325-37. PMID: 11025557.
    Citations:    Fields:    Translation:HumansAnimalsCells
  83. Yan G, Schoenfeld D, Penney C, Hurxthal K, Taylor AE, Faustman D. Identification of premature ovarian failure patients with underlying autoimmunity. J Womens Health Gend Based Med. 2000 Apr; 9(3):275-87. PMID: 10787223.
    Citations: 14     Fields:    Translation:HumansCells
  84. Hayashi T, Faustman D. Essential role of human leukocyte antigen-encoded proteasome subunits in NF-kappaB activation and prevention of tumor necrosis factor-alpha-induced apoptosis. J Biol Chem. 2000 Feb 18; 275(7):5238-47. PMID: 10671572.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  85. Hayashi T, Faustman D. Defective function of the proteasome in autoimmunity: involvement of impaired NF-kappaB activation. Diabetes Technol Ther. 2000; 2(3):415-28. PMID: 11467344.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  86. Hayashi T, Faustman D. A role for NF-kappaB and the proteasome in autoimmunity. Arch Immunol Ther Exp (Warsz). 2000; 48(5):353-65. PMID: 11140462.
    Citations: 1     Fields:    Translation:AnimalsCells
  87. Faustman DL. Antibodies for transplantation. Methods Mol Med. 2000; 40:141-56. PMID: 21337088.
    Citations:    Fields:    
  88. Hayashi T, Faustman D. NOD mice are defective in proteasome production and activation of NF-kappaB. Mol Cell Biol. 1999 Dec; 19(12):8646-59. PMID: 10567588.
    Citations: 40     Fields:    Translation:AnimalsCells
  89. Faustman D. On the periphery: Nature questions the role of women in science. J Womens Health Gend Based Med. 1999 Oct; 8(8):1009-10. PMID: 10565656.
    Citations:    Fields:    Translation:Humans
  90. Yan G, Shi L, Faustman D. Novel splicing of the human MHC-encoded peptide transporter confers unique properties. J Immunol. 1999 Jan 15; 162(2):852-9. PMID: 9916708.
    Citations: 6     Fields:    Translation:HumansCells
  91. Fu Y, Yan G, Shi L, Faustman D. Antigen processing and autoimmunity. Evaluation of mRNA abundance and function of HLA-linked genes. Ann N Y Acad Sci. 1998 Apr 15; 842:138-55. PMID: 9599304.
    Citations: 11     Fields:    Translation:HumansCells
  92. Yan G, Shi L, Fu Y, Wang X, Schoenfeld D, Ma L, Penfornis A, Gebel H, Faustman DL. Screening of the TAP1 gene by denaturing gradient gel electrophoresis in insulin-dependent diabetes mellitus: detection and comparison of new polymorphisms between patients and controls. Tissue Antigens. 1997 Dec; 50(6):576-85. PMID: 9458110.
    Citations: 1     Fields:    Translation:HumansCells
  93. Faustman DL. Gender is important: lessons in autoimmunity. J Womens Health. 1997 Oct; 6(5):521-2. PMID: 9356974.
    Citations:    Fields:    Translation:Humans
  94. Yan G, Fu Y, Faustman DL. Reduced expression of Tap1 and Lmp2 antigen-processing genes in the nonobese diabetic (NOD) mouse due to a mutation in their shared bidirectional promoter. J Immunol. 1997 Sep 15; 159(6):3068-80. PMID: 9300732.
    Citations: 16     Fields:    Translation:AnimalsCells
  95. Lernmark A, Eisenbarth G, Ducat L, Erlich HA, Faustman D, Maclaren NK, Ott J, Permutt MA, She JX, Todd J. Family cell lines available for research--an endangered resource? Am J Hum Genet. 1997 Sep; 61(3):778-9. PMID: 9326346; PMCID: PMC1715934.
    Citations: 1     Fields:    Translation:HumansCells
  96. Tambur AR, Foster P, Mellins E, Cresswell P, Faustman D, Gebel HM. Ultraviolet B irradiation reduces the surface expression of conformationally correct class I and II histocompatibility antigens. Transplant Proc. 1997 Sep; 29(6):2689-91. PMID: 9290791.
    Citations:    Fields:    Translation:HumansCells
  97. Shi L, Yan G, Fu Y, Ma L, Penfornis A, Faustman D. Human TAP1 polymorphisms detected by denaturing gradient gel electrophoresis. Tissue Antigens. 1997 Apr; 49(4):421-6. PMID: 9151396.
    Citations: 1     Fields:    Translation:Humans
  98. Ma L, Penfornis A, Wang X, Schoenfeld D, Tuomilehto-Wolf E, Metcalfe K, Hitman G, Faustman D. Evaluation of TAP1 polymorphisms with insulin dependent diabetes mellitus in Finnish diabetic patients. The Childhood Diabetes in Finland (DiMe) Study Group. Hum Immunol. 1997 Apr 01; 53(2):159-66. PMID: 9129974.
    Citations: 5     Fields:    Translation:Humans
  99. Pinies JA, Fu Y, Vazquez JA, Faustman D. New monoclonal antibody diagnostic reagents for type I diabetes: differential lymphocyte surface antigen expression related to disease. Diabetes. 1997 Mar; 46(3):363-71. PMID: 9032090.
    Citations:    Fields:    Translation:HumansAnimalsCells
  100. Huang R, Guo J, Li X, Faustman DL. Elimination of self-peptide major histocompatibility complex class I reactivity in NOD and beta 2-microglobulin-negative mice. Diabetes. 1995 Sep; 44(9):1114-20. PMID: 7657037.
    Citations: 1     Fields:    Translation:AnimalsCells
  101. Wang F, Li X, Annis B, Faustman DL. Tap-1 and Tap-2 gene therapy selectively restores conformationally dependent HLA Class I expression in type I diabetic cells. Hum Gene Ther. 1995 Aug; 6(8):1005-17. PMID: 7578413.
    Citations: 4     Fields:    Translation:HumansCells
  102. Li F, Linan MJ, Stein MC, Faustman DL. Reduced expression of peptide-loaded HLA class I molecules on multiple sclerosis lymphocytes. Ann Neurol. 1995 Aug; 38(2):147-54. PMID: 7654061.
    Citations: 3     Fields:    Translation:HumansCells
  103. Faustman DL. Altered MHC class I expression: a role for transplantation and IDDM autoimmunity. Diabetes Metab Rev. 1995 Apr; 11(1):1-19. PMID: 7600904.
    Citations:    Fields:    Translation:HumansAnimals
  104. Faustman D. Strategies for circumventing transplant rejection: modification of cells, tissues and organs. Trends Biotechnol. 1995 Mar; 13(3):100-5. PMID: 7766216.
    Citations:    Fields:    Translation:HumansCells
  105. Vidal-Puig A, Faustman DL. Tolerance to peripheral tissue is transient and maintained by tissue-specific class I expression. Transplant Proc. 1994 Dec; 26(6):3314-6. PMID: 7998151.
    Citations: 2     Fields:    Translation:Animals
  106. Li F, Guo J, Fu Y, Yan G, Faustman D. Abnormal class I assembly and peptide presentation in the nonobese diabetic mouse. Proc Natl Acad Sci U S A. 1994 Nov 08; 91(23):11128-32. PMID: 7972022; PMCID: PMC45180.
    Citations: 11     Fields:    Translation:AnimalsCells
  107. Faustman DL. Occult CD45 T cell developmental defect in type 1 diabetes. Diabete Metab. 1993 Sep-Oct; 19(5):446-57. PMID: 8056125.
    Citations: 4     Fields:    Translation:HumansCells
  108. Li X, Golden J, Faustman DL. Faulty major histocompatibility complex class II I-E expression is associated with autoimmunity in diverse strains of mice. Autoantibodies, insulitis, and sialadenitis. Diabetes. 1993 Aug; 42(8):1166-72. PMID: 8325448.
    Citations: 4     Fields:    Translation:Animals
  109. Fu Y, Nathan DM, Li F, Li X, Faustman DL. Defective major histocompatibility complex class I expression on lymphoid cells in autoimmunity. J Clin Invest. 1993 May; 91(5):2301-7. PMID: 8486790; PMCID: PMC288235.
    Citations: 17     Fields:    Translation:HumansCells
  110. Li X, Faustman D. Use of donor beta 2-microglobulin-deficient transgenic mouse liver cells for isografts, allografts, and xenografts. Transplantation. 1993 Apr; 55(4):940-6. PMID: 8475570.
    Citations: 9     Fields:    Translation:AnimalsCells
  111. Hardiman O, Faustman D, Li X, Sklar RM, Brown RH. Expression of major histocompatibility complex antigens in cultures of clonally derived human myoblasts. Neurology. 1993 Mar; 43(3 Pt 1):604-8. PMID: 8451007.
    Citations: 1     Fields:    Translation:HumansCells
  112. Faustman D. Mechanisms of autoimmunity in type I diabetes. J Clin Immunol. 1993 Jan; 13(1):1-7. PMID: 8445041.
    Citations:    Fields:    Translation:HumansAnimals
  113. Faustman DL. MHC class I and autoimmune diabetes. Biomed Pharmacother. 1993; 47(1):3-10. PMID: 7872965.
    Citations: 1     Fields:    Translation:Animals
  114. Faustman D. Faulty major histocompatibility complex class I function linked to autoimmune diabetes. Transplant Proc. 1992 Dec; 24(6):2874-6. PMID: 1465979.
    Citations:    Fields:    Translation:HumansAnimals
  115. Faustman D, Coe C. Xenograft acceptance by masking donor antigens. Transplant Proc. 1992 Dec; 24(6):2854-5. PMID: 1465972.
    Citations:    Fields:    Translation:HumansAnimalsCells
  116. Faustman D, Li X, Lin HY, Huang R, Guo J. Response. Science. 1992 Jun 26; 256(5065):1830-1. PMID: 17743036.
    Citations: 3     Fields:    
  117. Lanza RP, Butler DH, Borland KM, Harvey JM, Faustman DL, Solomon BA, Muller TE, Rupp RG, Maki T, Monaco AP, et al. Successful xenotransplantation of a diffusion-based biohybrid artificial pancreas: a study using canine, bovine, and porcine islets. Transplant Proc. 1992 Apr; 24(2):669-71. PMID: 1566475.
    Citations: 2     Fields:    Translation:Animals
  118. Faustman D, Li XP, Lin HY, Fu YE, Eisenbarth G, Avruch J, Guo J. Linkage of faulty major histocompatibility complex class I to autoimmune diabetes. Science. 1991 Dec 20; 254(5039):1756-61. PMID: 1763324.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  119. Lanza RP, Butler DH, Borland KM, Staruk JE, Faustman DL, Solomon BA, Muller TE, Rupp RG, Maki T, Monaco AP, et al. Xenotransplantation of canine, bovine, and porcine islets in diabetic rats without immunosuppression. Proc Natl Acad Sci U S A. 1991 Dec 15; 88(24):11100-4. PMID: 1763025; PMCID: PMC53081.
    Citations: 15     Fields:    Translation:Animals
  120. Faustman D, Coe C. Prevention of xenograft rejection by masking donor HLA class I antigens. Science. 1991 Jun 21; 252(5013):1700-2. PMID: 1710828.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  121. Faustman D, Schoenfeld D, Ziegler R. T-lymphocyte changes linked to autoantibodies. Association of insulin autoantibodies with CD4+CD45R+ lymphocyte subpopulation in prediabetic subjects. Diabetes. 1991 May; 40(5):590-7. PMID: 1827080.
    Citations: 10     Fields:    Translation:HumansCells
  122. Faustman D, Eisenbarth G, Breitmeyer J. Analysis of T lymphocyte subsets in all stages of diabetes. J Autoimmun. 1990 Apr; 3 Suppl 1:111-6. PMID: 2340061.
    Citations: 2     Fields:    Translation:HumansCells
  123. Faustman D, Eisenbarth G, Daley J, Breitmeyer J. Abnormal T-lymphocyte subsets in type I diabetes. Diabetes. 1989 Nov; 38(11):1462-8. PMID: 2533573.
    Citations: 22     Fields:    Translation:HumansCells
  124. Breitmeyer JB, Faustman DL. Sheep erythrocyte rosetting induces multiple alterations in T lymphocyte function: inhibition of T cell receptor activity and stimulation of T11/CD2. Cell Immunol. 1989 Oct 01; 123(1):118-33. PMID: 2570643.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  125. Faustman DL, Hauptfeld V, Davie JM, Lacy PE. Prolonged survival of donor skin grafts on mice bearing established islet of Langerhans transplants. Transplantation. 1985 Aug; 40(2):216-8. PMID: 3927534.
    Citations: 1     Fields:    Translation:Animals
  126. Rossini AA, Faustman D, Woda BA, Like AA, Szymanski I, Mordes JP. Lymphocyte transfusions prevent diabetes in the Bio-Breeding/Worcester rat. J Clin Invest. 1984 Jul; 74(1):39-46. PMID: 6610693; PMCID: PMC425182.
    Citations: 19     Fields:    Translation:AnimalsCells
  127. Faustman DL, Steinman RM, Gebel HM, Hauptfeld V, Davie JM, Lacy PE. Prevention of rejection of murine islet allografts by pretreatment with anti-dendritic cell antibody. Proc Natl Acad Sci U S A. 1984 Jun; 81(12):3864-8. PMID: 6427778; PMCID: PMC345322.
    Citations: 62     Fields:    Translation:AnimalsCells
  128. Faustman D, Kraus P, Lacy PE, Finke EH, Davie JM. Survival of heart allografts in nonimmunosuppressed murine recipients by pretreatment of the donor tissue with anti-Ia antibodies. Transplantation. 1982 Nov; 34(5):302-5. PMID: 6961607.
    Citations: 1     Fields:    Translation:Animals
  129. Faustman D, Lacy PE, Davie JM. Transplantation without immunosuppression. Diabetes. 1982 Aug; 31 Suppl 4:11-6. PMID: 6819960.
    Citations: 5     Fields:    Translation:AnimalsCells
  130. Faustman D, Lacy P, Davie J, Hauptfeld V. Prevention of allograft rejection by immunization with donor blood depleted of Ia-bearing cells. Science. 1982 Jul 09; 217(4555):157-8. PMID: 6806903.
    Citations: 11     Fields:    Translation:AnimalsCellsPHPublic Health
  131. Faustman D, Hauptfeld V, Lacy P, Davie J. Demonstration of active tolerance in maintenance of established islet of Langerhans allografts. Proc Natl Acad Sci U S A. 1982 Jul; 79(13):4153-5. PMID: 6810361; PMCID: PMC346595.
    Citations: 3     Fields:    Translation:Animals
  132. Faustman D, Hauptfeld V, Lacy P, Davie J. Prolongation of murine islet allograft survival by pretreatment of islets with antibody directed to Ia determinants. Proc Natl Acad Sci U S A. 1981 Aug; 78(8):5156-9. PMID: 6795629; PMCID: PMC320354.
    Citations: 38     Fields:    Translation:Animals
  133. Faustman D, Hauptfeld V, Davie JM, Lacy PE, Shreffler DC. Murine pancreatic beta-cells express H-2K and H-2D but not Ia antigens. J Exp Med. 1980 Jun 01; 151(6):1563-8. PMID: 6991630; PMCID: PMC2185869.
    Citations: 16     Fields:    Translation:Animals
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