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Jill M. Goldstein, Ph.D.

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Biography
Brown University , Providence, RIA.B.05/1976Psychological Anthropology
Columbia University School of Public Health, NY, NYM.P.H05/1979Mental Health Evaluation
Columbia University Graduate School of Arts and Sciences, NY, NYPh.D.05/1985Epidemiology in Psychiatry
Harvard Medical School, Beth Israel & Massachusetts General Hospitals, Boston, MAPostdoctoral05/1994Clinical Neuroscience
Harvard University, Cambridge, MAHonorary M.A.2004In Honor of Harvard Professorship
1987 - 1989
Schizophrenia Research Program Award
1989 - 1989
NIMH Young Investigator Award
1989 - 1991
Young Investigator Award for Scientific Research
1990 - 1991
William F. Milton Fund Award for Scientific Research
1991 - 1992
NIMH Clinical Research Fellowship Award in Biological Psychiatry
2002 - 2003
Collaborative Research Award
2005 - 2005
Award for Exploratory Seminar on the “Genetics of Sex Effects in Clinical Medicine”
2007 - 2007
Selected the 2007 Spinoza Professor
2008 - 2008
Award for Exploratory Seminar on “Unexplored Sex Differences in Cardiovascular Disease”
2013 - 2013
Stuart T. Hauser Mentorship Award in Psychiatry
2015 - 2015
Distinguished Scientist Award
2015 - 2015
Award for Workshop entitled "Sex-Dependent NeuroDiscovery and CNS Therapeutics"
2018 - 2018
Award for Women, Heart and Brain Global Initiative Stakeholders Meeting
2018
Helen T. Moerschner Endowed MGH Research Institute Chair in Women's Health
2018
Founder and Executive Director of the Innovation Center on Sex Differences in Medicine

Overview
Introduction: I have had a long-standing interest in sex differences in the brain and the roles of steroid hormones, genes, and markers of immune function in understanding sex differences in psychiatric disorders and their comorbidity with general medicine. I believe that an understanding of these pathways will provide knowledge for the development of novel sex-dependent therapeutic discovery. For >30 years at Harvard, I have been working with colleagues that span Harvard schools and departments and other collaborative institutions that integrate fields of study, methods of analysis, and levels of study from basic to clinical to tackle issues of sex differences in medicine and women's health. Relatively little is known about how sex differences in healthy brain development may or may not deviate in producing pathology and the impact on treatment. Further, clinical decisions based on research are primarily based on data from males that are often inappropriate for females, even for disorders (like depression) in which women predominate. Given the gap between the clinical and scientific importance of studying sex effects in medicine and the relative paucity of studies on these issues, the history of my work has contributed to moving this field forward.

History of Research: My laboratory, called the Clinical Neuroscience Laboratory of Sex Differences in the Brain, has been ongoing for >25 years (http://cnl-sd.mgh.harvard.edu). Our team consists of an interdisciplinary group of investigators, integrating structural and functional MRI studies, psychophysiology, steroid hormones, markers of immune function, genetics, and collaborative efforts with preclinical investigators modeling steroid hormones, genes, immune function, and the brain. The first disorder of interest was schizophrenia, a devastating illness for which men have a higher risk than women. Although in the 1980’s, the prevailing ideology was that it was similar in men and women, my team was instrumental in demonstrating that men have a significantly higher risk than women, the causes for which begin during mid-gestation, a key period of the sexual differentiation of the brain. Our studies of sex differences in cognitive functions identified specific domains in which women compared with men had relative preservation of function, i.e. language, executive functions, verbal memory, and olfaction. Using structural and functional MRI, my team identified brain abnormalities in schizophrenia in regions associated with sex differences in cognitive and affective functions. These brain regions, rich in gonadal hormone receptors, led to studies with basic neuroscience colleagues to map out prenatal stress and immune mechanisms associated with the dysregulation of the sexual differentiation of the brain during mid-gestation. We further demonstrated similar causal pathways for understanding sex differences in the risk for major depressive disorder, but for which women have a significantly higher risk than men.

Over the last 15 years, the lab has focused on sex differences in major depression and why it is highly comorbid with cardiovascular disease and risk for Alzheimer’s disease later in life. We continue to take a lifespan approach to understanding sex differences in the shared causes of these disorders of the heart and brain. Included in this work, I oversee a unique prenatal cohort study in which subjects have prospective data from pregnancy through their 60’s, including brain imaging, allowing us to investigate in a human population the fetal programming of adult onset disorders, a topic primarily studied in animals. Our work has contributed to identifying fetal stress-immune biomarkers that disrupt the sexual differentiation of the brain and that are retained and expressed in adulthood as sex differences in deficits in stress response circuitry, major depression, and comorbid physiologic and cardiac dysfunction. In 2018, I launched the Innovation Center on Sex Differences in Medicine (ICON), a collaborative effort between Massachusetts General Hospital and the Harvard T. H. Chan School of Public Health, partnering with WomenAgainstAlzheimers (http://icon.mgh.harvard.edu). ICON consists of collaborators across departments, fields and methodologies bringing together psychiatry, OB-GYN, cardiology, neurology, and public health. ICON’s primary mission is to leverage fundamental discoveries “from cells to society” about sex differences in the brain and heart into strategies to develop sex-dependent therapeutics and target them early for prevention. In addition, we are invested in educating the next generation of scientists, clinicians, and the public about sex differences in medicine and advocating for these issues at the national and global levels. In 2020, ICON was designated an NIH Specialized Center of Research Excellence (SCORE) for Sex Differences in Medicine, one of only 8 in the country.

Finally, I have spent my career educating the next generation of scientists and clinicians to study sex differences in health and disease across disciplines and methods and providing resources for their careers in women’s health and sex differences in medicine. In the service of this for >15 years, I have been the PI of a Harvard-wide junior faculty training program (ORWH-NICHD K12 HD051959-06) called Building Interdisciplinary Careers in Women's Health (BIRCWH) with ours targeted to "Hormones and Genes in Women's Health: From Bench to Bedside". With a translational focus, BIRCWH is training the next generation to investigate sex differences in medicine, and/or women's health specifically, and incorporate the knowledge into their academic and clinical careers in medicine.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. RF1AG074008 (GOLDSTEIN, JILL M) Sep 30, 2021 - Aug 31, 2024
    NIH
    Impact of sex differences in immune function on shared risk for cardiometabolic disorder & Alzheimer's disease
    Role: Principal Investigator
  2. U54MH118919 (GOLDSTEIN, JILL M) Feb 1, 2020 - Dec 31, 2024
    NIH
    Sex Differences in Major Depression: Impact of Prenatal Stress-Immune and Autonomic Dysregulation
    Role: Principal Investigator
  3. R01AG067019 (GOLDSTEIN, JILL M) Sep 15, 2019 - May 31, 2024
    NIH
    Impact of Depression on Alzheimer's disease: Prenatal Immune Origins and Shared Impact of Sex
    Role: Principal Investigator
  4. R01AG057505 (GOLDSTEIN, JILL M) Jun 15, 2018 - Feb 28, 2023
    NIH
    Aging of Emotion Circuitry: Impact of Sex, Depression, and Fetal Immune Origins
    Role: Principal Investigator
  5. R56MH113217 (GOLDSTEIN, JILL M) Sep 20, 2017 - Aug 31, 2018
    NIH
    Prenatal Immune Programming of Sex Differences in Dysregulation of Emotion Processing in Midlife
    Role: Principal Investigator

Featured Content

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Mountain RV, Zhu Y, Pickett OR, Lussier AA, Goldstein JM, Roffman JL, Bidlack FB, Dunn EC. Association of Maternal Stress and Social Support During Pregnancy With Growth Marks in Children's Primary Tooth Enamel. JAMA Netw Open. 2021 11 01; 4(11):e2129129. PMID: 34751761.
    Citations: 3     Fields:    Translation:Humans
  2. Chang RS, Cerit H, Hye T, Durham EL, Aizley H, Boukezzi S, Haimovici F, Goldstein JM, Dillon DG, Pizzagalli DA, Holsen LM. Stress-induced alterations in HPA-axis reactivity and mesolimbic reward activation in individuals with emotional eating. Appetite. 2022 01 01; 168:105707. PMID: 34562531.
    Citations: 1     Fields:    Translation:Humans
  3. Holsen LM, Hoge WS, Lennerz BS, Cerit H, Hye T, Moondra P, Goldstein JM, Ebbeling CB, Ludwig DS. Diets Varying in Carbohydrate Content Differentially Alter Brain Activity in Homeostatic and Reward Regions in Adults. J Nutr. 2021 08 07; 151(8):2465-2476. PMID: 33852013.
    Citations: 2     Fields:    Translation:Humans
  4. Ironside M, Moser AD, Holsen LM, Zuo CS, Du F, Perlo S, Richards CE, Duda JM, Chen X, Nickerson LD, Null KE, Nascimento N, Crowley DJ, Misra M, Goldstein JM, Pizzagalli DA. Reductions in rostral anterior cingulate GABA are associated with stress circuitry in females with major depression: a multimodal imaging investigation. Neuropsychopharmacology. 2021 11; 46(12):2188-2196. PMID: 34363015.
    Citations:    Fields:    Translation:Humans
  5. Garcia RG, Cohen JE, Stanford AD, Gabriel A, Stowell J, Aizley H, Barbieri R, Gitlin D, Napadow V, Goldstein JM. Respiratory-gated auricular vagal afferent nerve stimulation (RAVANS) modulates brain response to stress in major depression. J Psychiatr Res. 2021 10; 142:188-197. PMID: 34365067.
    Citations:    Fields:    Translation:Humans
  6. Goldstein JM, Cohen JE, Mareckova K, Holsen L, Whitfield-Gabrieli S, Gilman SE, Buka SL, Hornig M. Impact of prenatal maternal cytokine exposure on sex differences in brain circuitry regulating stress in offspring 45 years later. Proc Natl Acad Sci U S A. 2021 04 13; 118(15). PMID: 33876747.
    Citations: 4     Fields:    Translation:Humans
  7. Blokland GAM, Grove J, Chen CY, Cotsapas C, Tobet S, Handa R, St Clair D, Lencz T, Mowry BJ, Periyasamy S, Cairns MJ, Tooney PA, Wu JQ, Kelly B, Kirov G, Sullivan PF, Corvin A, Riley BP, Esko T, Milani L, Jönsson EG, Palotie A, Ehrenreich H, Begemann M, Steixner-Kumar A, Sham PC, Iwata N, Weinberger DR, Gejman PV, Sanders AR, Buxbaum JD, Rujescu D, Giegling I, Konte B, Hartmann AM, Bramon E, Murray RM, Pato MT, Lee J, Melle I, Molden E, Ophoff RA, McQuillin A, Bass NJ, Adolfsson R, Malhotra AK, Martin NG, Fullerton JM, Mitchell PB, Schofield PR, Forstner AJ, Degenhardt F, Schaupp S, Comes AL, Kogevinas M, Guzman-Parra J, Reif A, Streit F, Sirignano L, Cichon S, Grigoroiu-Serbanescu M, Hauser J, Lissowska J, Mayoral F, Müller-Myhsok B, Swiatkowska B, Schulze TG, Nöthen MM, Rietschel M, Kelsoe J, Leboyer M, Jamain S, Etain B, Bellivier F, Vincent JB, Alda M, O'Donovan C, Cervantes P, Biernacka JM, Frye M, McElroy SL, Scott LJ, Stahl EA, Landén M, Hamshere ML, Smeland OB, Djurovic S, Vaaler AE, Andreassen OA, Baune BT, Air T, Preisig M, Uher R, Levinson DF, Weissman MM, Potash JB, Shi J, Knowles JA, Perlis RH, Lucae S, Boomsma DI, Penninx BWJH, Hottenga JJ, de Geus EJC, Willemsen G, Milaneschi Y, Tiemeier H, Grabe HJ, Teumer A, Van der Auwera S, Völker U, Hamilton SP, Magnusson PKE, Viktorin A, Mehta D, Mullins N, Adams MJ, Breen G, McIntosh AM, Lewis CM, Hougaard DM, Nordentoft M, Mors O, Mortensen PB, Werge T, Als TD, Børglum AD, Petryshen TL, Smoller JW, Goldstein JM. Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders. Biol Psychiatry. 2022 01 01; 91(1):102-117. PMID: 34099189.
    Citations: 7     Fields:    Translation:HumansCells
  8. Holsen LM, Huang G, Cherkerzian S, Aroner S, Loucks EB, Buka S, Handa RJ, Goldstein JM. Sex Differences in Hemoglobin A1c Levels Related to the Comorbidity of Obesity and Depression. J Womens Health (Larchmt). 2021 09; 30(9):1303-1312. PMID: 33534642.
    Citations:    Fields:    Translation:Humans
  9. Martin J, Khramtsova EA, Goleva SB, Blokland GAM, Traglia M, Walters RK, Hübel C, Coleman JRI, Breen G, Børglum AD, Demontis D, Grove J, Werge T, Bralten J, Bulik CM, Lee PH, Mathews CA, Peterson RE, Winham SJ, Wray N, Edenberg HJ, Guo W, Yao Y, Neale BM, Faraone SV, Petryshen TL, Weiss LA, Duncan LE, Goldstein JM, Smoller JW, Stranger BE, Davis LK. Examining Sex-Differentiated Genetic Effects Across Neuropsychiatric and Behavioral Traits. Biol Psychiatry. 2021 06 15; 89(12):1127-1137. PMID: 33648717.
    Citations: 7     Fields:    Translation:Humans
  10. Goldstein JM, Langer A, Lesser JA. Sex Differences in Disorders of the Brain and Heart-A Global Crisis of Multimorbidity and Novel Opportunity. JAMA Psychiatry. 2021 01 01; 78(1):7-8. PMID: 32639554.
    Citations: 1     Fields:    Translation:HumansPHPublic Health
  11. Duda JM, Moser AD, Zuo CS, Du F, Chen X, Perlo S, Richards CE, Nascimento N, Ironside M, Crowley DJ, Holsen LM, Misra M, Hudson JI, Goldstein JM, Pizzagalli DA. Repeatability and reliability of GABA measurements with magnetic resonance spectroscopy in healthy young adults. Magn Reson Med. 2021 05; 85(5):2359-2369. PMID: 33216412.
    Citations: 3     Fields:    Translation:Humans
  12. Ghassabian A, Hornig M, Chen Z, Yeung E, Buka SL, Yu J, Ma G, Goldstein JM, Gilman SE. Gestational Cytokines and the Developmental Expression of Obesity in Childhood. Obesity (Silver Spring). 2020 11; 28(11):2192-2200. PMID: 32985128.
    Citations:    Fields:    Translation:Humans
  13. Yu J, Ghassabian A, Chen Z, Goldstein RB, Hornig M, Buka SL, Goldstein JM, Gilman SE. Maternal Immune activity during pregnancy and socioeconomic disparities in children's self-regulation. Brain Behav Immun. 2020 11; 90:346-352. PMID: 32919039.
    Citations: 1     Fields:    Translation:Humans
  14. Huang G, Aroner SA, Bay CP, Gilman SE, Ghassabian A, Loucks EB, Buka SL, Handa RJ, Lasley BL, Bhasin S, Goldstein JM. Sex-dependent associations of maternal androgen levels with offspring BMI and weight trajectory from birth to early childhood. J Endocrinol Invest. 2021 Apr; 44(4):851-863. PMID: 32776198.
    Citations: 1     Fields:    Translation:Humans
  15. Staley R, Garcia RG, Stowell J, Sclocco R, Fisher H, Napadow V, Goldstein JM, Barbieri R. Modulatory Effects of Respiratory-Gated Auricular Vagal Nerve Stimulation on Cardiovagal Activity in Hypertension. Annu Int Conf IEEE Eng Med Biol Soc. 2020 07; 2020:2581-2584. PMID: 33018534.
    Citations: 1     Fields:    Translation:Humans
  16. Bartz D, Chitnis T, Kaiser UB, Rich-Edwards JW, Rexrode KM, Pennell PB, Goldstein JM, O'Neal MA, LeBoff M, Behn M, Seely EW, Joffe H, Manson JE. Clinical Advances in Sex- and Gender-Informed Medicine to Improve the Health of All: A Review. JAMA Intern Med. 2020 04 01; 180(4):574-583. PMID: 32040165.
    Citations: 32     Fields:    Translation:Humans
  17. Sclocco R, Garcia RG, Kettner NW, Fisher HP, Isenburg K, Makarovsky M, Stowell JA, Goldstein J, Barbieri R, Napadow V. Stimulus frequency modulates brainstem response to respiratory-gated transcutaneous auricular vagus nerve stimulation. Brain Stimul. 2020 Jul - Aug; 13(4):970-978. PMID: 32380448.
    Citations: 7     Fields:    Translation:Humans
  18. Garcia RG, Mareckova K, Holsen LM, Cohen JE, Whitfield-Gabrieli S, Napadow V, Barbieri R, Goldstein JM. Impact of sex and depressed mood on the central regulation of cardiac autonomic function. Neuropsychopharmacology. 2020 07; 45(8):1280-1288. PMID: 32152473.
    Citations: 5     Fields:    Translation:Humans
  19. Konishi K, Cherkerzian S, Aroner S, Jacobs EG, Rentz DM, Remington A, Aizley H, Hornig M, Klibanski A, Goldstein JM. Impact of BDNF and sex on maintaining intact memory function in early midlife. Neurobiol Aging. 2020 04; 88:137-149. PMID: 31948671.
    Citations: 3     Fields:    Translation:Humans
  20. Goldstein JM, Valido A, Lewandowski JP, Walker RG, Mills MJ, Messemer KA, Besseling P, Lee KH, Wattrus SJ, Cho M, Lee RT, Wagers AJ. Variation in zygotic CRISPR/Cas9 gene editing outcomes generates novel reporter and deletion alleles at the Gdf11 locus. Sci Rep. 2019 12 09; 9(1):18613. PMID: 31819086.
    Citations:    Fields:    Translation:AnimalsCells
  21. Goldstein JM, Sengul H, Messemer KA, Fernández-Alfara M, Garbern JC, Kristl AC, Lee RT, Wagers AJ. Steady-state and regenerative hematopoiesis occurs normally in mice in the absence of GDF11. Blood. 2019 11 14; 134(20):1712-1716. PMID: 31530563.
    Citations: 4     Fields:    Translation:AnimalsCells
  22. Lewandowski JP, Lee JC, Hwang T, Sunwoo H, Goldstein JM, Groff AF, Chang NP, Mallard W, Williams A, Henao-Meija J, Flavell RA, Lee JT, Gerhardinger C, Wagers AJ, Rinn JL. The Firre locus produces a trans-acting RNA molecule that functions in hematopoiesis. Nat Commun. 2019 11 13; 10(1):5137. PMID: 31723143.
    Citations: 16     Fields:    Translation:Animals
  23. Cerit H, Davidson P, Hye T, Moondra P, Haimovici F, Sogg S, Shikora S, Goldstein JM, Evins AE, Whitfield-Gabrieli S, Stoeckel LE, Holsen LM. Resting-State Brain Connectivity Predicts Weight Loss and Cognitive Control of Eating Behavior After Vertical Sleeve Gastrectomy. Obesity (Silver Spring). 2019 11; 27(11):1846-1855. PMID: 31689011.
    Citations: 5     Fields:    Translation:Humans
  24. Lee YH, Cherkerzian S, Seidman LJ, Papandonatos GD, Savitz DA, Tsuang MT, Goldstein JM, Buka SL. Maternal Bacterial Infection During Pregnancy and Offspring Risk of Psychotic Disorders: Variation by Severity of Infection and Offspring Sex. Am J Psychiatry. 2020 01 01; 177(1):66-75. PMID: 31581799.
    Citations: 8     Fields:    Translation:Humans
  25. Fitzsimmons J, Rosa P, Sydnor VJ, Reid BE, Makris N, Goldstein JM, Mesholam-Gately RI, Woodberry K, Wojcik J, McCarley RW, Seidman LJ, Shenton ME, Kubicki M. Cingulum bundle abnormalities and risk for schizophrenia. Schizophr Res. 2020 01; 215:385-391. PMID: 31477373.
    Citations: 6     Fields:    Translation:HumansCells
  26. Konishi K, Cherkerzian S, Jacobs EG, Richards C, Remington A, Aizley H, Misra M, Lasley BL, Goldstein JM. Impact of adrenal hormones, reproductive aging, and major depression on memory circuitry decline in early midlife. Brain Res. 2019 10 15; 1721:146303. PMID: 31279842.
    Citations: 1     Fields:    Translation:Humans
  27. Garbern J, Kristl AC, Bassaneze V, Vujic A, Schoemaker H, Sereda R, Peng L, Ricci-Blair EM, Goldstein JM, Walker RG, Bhasin S, Wagers AJ, Lee RT. Analysis of Cre-mediated genetic deletion of Gdf11 in cardiomyocytes of young mice. Am J Physiol Heart Circ Physiol. 2019 07 01; 317(1):H201-H212. PMID: 31125255.
    Citations: 10     Fields:    Translation:AnimalsCells
  28. Goldstein JM, Tabebordbar M, Zhu K, Wang LD, Messemer KA, Peacker B, Ashrafi Kakhki S, Gonzalez-Celeiro M, Shwartz Y, Cheng JKW, Xiao R, Barungi T, Albright C, Hsu YC, Vandenberghe LH, Wagers AJ. In Situ Modification of Tissue Stem and Progenitor Cell Genomes. Cell Rep. 2019 04 23; 27(4):1254-1264.e7. PMID: 31018138.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  29. Oribe N, Hirano Y, Del Re E, Seidman LJ, Mesholam-Gately RI, Woodberry KA, Wojcik JD, Ueno T, Kanba S, Onitsuka T, Shenton ME, Goldstein JM, Niznikiewicz MA, McCarley RW, Spencer KM. Progressive reduction of auditory evoked gamma in first episode schizophrenia but not clinical high risk individuals. Schizophr Res. 2019 06; 208:145-152. PMID: 31005464.
    Citations: 9     Fields:    Translation:Humans
  30. Lyall AE, Savadjiev P, Del Re EC, Seitz J, O'Donnell LJ, Westin CF, Mesholam-Gately RI, Petryshen T, Wojcik JD, Nestor P, Niznikiewicz M, Goldstein J, Seidman LJ, McCarley RW, Shenton ME, Kubicki M. Utilizing Mutual Information Analysis to Explore the Relationship Between Gray and White Matter Structural Pathologies in Schizophrenia. Schizophr Bull. 2019 03 07; 45(2):386-395. PMID: 29618096.
    Citations: 1     Fields:    Translation:Humans
  31. Sclocco R, Garcia RG, Kettner NW, Isenburg K, Fisher HP, Hubbard CS, Ay I, Polimeni JR, Goldstein J, Makris N, Toschi N, Barbieri R, Napadow V. The influence of respiration on brainstem and cardiovagal response to auricular vagus nerve stimulation: A multimodal ultrahigh-field (7T) fMRI study. Brain Stimul. 2019 Jul - Aug; 12(4):911-921. PMID: 30803865.
    Citations: 19     Fields:    Translation:HumansAnimals
  32. Seitz J, Kubicki M, Jacobs EG, Cherkerzian S, Weiss BK, Papadimitriou G, Mouradian P, Buka S, Goldstein JM, Makris N. Impact of sex and reproductive status on memory circuitry structure and function in early midlife using structural covariance analysis. Hum Brain Mapp. 2019 03; 40(4):1221-1233. PMID: 30548738.
    Citations: 3     Fields:    Translation:Humans
  33. Kline E, Hendel V, Friedman-Yakoobian M, Mesholam-Gately RI, Findeisen A, Zimmet S, Wojcik JD, Petryshen TL, Woo TW, Goldstein JM, Shenton ME, Keshavan MS, McCarley RW, Seidman LJ. A comparison of neurocognition and functioning in first episode psychosis populations: do research samples reflect the real world? Soc Psychiatry Psychiatr Epidemiol. 2019 Mar; 54(3):291-301. PMID: 30488086.
    Citations: 4     Fields:    Translation:Humans
  34. Huang G, Cherkerzian S, Loucks EB, Buka SL, Handa RJ, Lasley BL, Bhasin S, Goldstein JM. Sex Differences in the Prenatal Programming of Adult Metabolic Syndrome by Maternal Androgens. J Clin Endocrinol Metab. 2018 11 01; 103(11):3945-3953. PMID: 30113645.
    Citations: 6     Fields:    Translation:Humans
  35. Wang YB, Chen Z, Goldstein JM, Buck Louis GM, Gilman SE. A Bayesian regularized mediation analysis with multiple exposures. Stat Med. 2019 02 28; 38(5):828-843. PMID: 30375022.
    Citations: 1     Fields:    Translation:Humans
  36. Cerit H, Christensen K, Moondra P, Klibanski A, Goldstein JM, Holsen LM. Divergent associations between ghrelin and neural responsivity to palatable food in hyperphagic and hypophagic depression. J Affect Disord. 2019 01 01; 242:29-38. PMID: 30170236.
    Citations: 4     Fields:    Translation:Humans
  37. Rich-Edwards JW, Kaiser UB, Chen GL, Manson JE, Goldstein JM. Sex and Gender Differences Research Design for Basic, Clinical, and Population Studies: Essentials for Investigators. Endocr Rev. 2018 08 01; 39(4):424-439. PMID: 29668873.
    Citations: 34     Fields:    Translation:Humans
  38. Konishi J, Del Re EC, Bouix S, Blokland GAM, Mesholam-Gately R, Woodberry K, Niznikiewicz M, Goldstein J, Hirayasu Y, Petryshen TL, Seidman LJ, Shenton ME, McCarley RW. Abnormal relationships between local and global brain measures in subjects at clinical high risk for psychosis: a pilot study. Brain Imaging Behav. 2018 Aug; 12(4):974-988. PMID: 28815390.
    Citations: 1     Fields:    Translation:Humans
  39. Goldstein JM, Hale T, Foster SL, Tobet SA, Handa RJ. Sex differences in major depression and comorbidity of cardiometabolic disorders: impact of prenatal stress and immune exposures. Neuropsychopharmacology. 2019 01; 44(1):59-70. PMID: 30030541.
    Citations: 26     Fields:    Translation:Humans
  40. Nebel RA, Aggarwal NT, Barnes LL, Gallagher A, Goldstein JM, Kantarci K, Mallampalli MP, Mormino EC, Scott L, Yu WH, Maki PM, Mielke MM. Understanding the impact of sex and gender in Alzheimer's disease: A call to action. Alzheimers Dement. 2018 09; 14(9):1171-1183. PMID: 29907423.
    Citations: 123     Fields:    Translation:HumansAnimals
  41. Jacobs EG, Goldstein JM. The Middle-Aged Brain: Biological sex and sex hormones shape memory circuitry. Curr Opin Behav Sci. 2018 Oct; 23:84-91. PMID: 30271832.
    Citations: 9     
  42. Goldstein JM. Impact of Prenatal Stress on Offspring Psychopathology and Comorbidity With General Medicine Later in Life. Biol Psychiatry. 2019 01 15; 85(2):94-96. PMID: 29576191.
    Citations: 4     Fields:    Translation:HumansAnimals
  43. Ghassabian A, Albert PS, Hornig M, Yeung E, Cherkerzian S, Goldstein RB, Buka SL, Goldstein JM, Gilman SE. Gestational cytokine concentrations and neurocognitive development at 7 years. Transl Psychiatry. 2018 03 13; 8(1):64. PMID: 29531226.
    Citations: 16     Fields:    Translation:Humans
  44. Pace LE, Chen GL, Chai J, Goldstein JM, Orton P, Bartz D, Rich-Edwards J, Manson JE, Johnson PA. Advancing Sex- and Gender-Informed Approaches to Health in an Academic Medical Center. Womens Health Issues. 2018 Mar - Apr; 28(2):117-121. PMID: 29249334.
    Citations: 2     Fields:    Translation:Humans
  45. Blokland GAM, Del Re EC, Mesholam-Gately RI, Jovicich J, Trampush JW, Keshavan MS, DeLisi LE, Walters JTR, Turner JA, Malhotra AK, Lencz T, Shenton ME, Voineskos AN, Rujescu D, Giegling I, Kahn RS, Roffman JL, Holt DJ, Ehrlich S, Kikinis Z, Dazzan P, Murray RM, Di Forti M, Lee J, Sim K, Lam M, Wolthusen RPF, de Zwarte SMC, Walton E, Cosgrove D, Kelly S, Maleki N, Osiecki L, Picchioni MM, Bramon E, Russo M, David AS, Mondelli V, Reinders AATS, Falcone MA, Hartmann AM, Konte B, Morris DW, Gill M, Corvin AP, Cahn W, Ho NF, Liu JJ, Keefe RSE, Gollub RL, Manoach DS, Calhoun VD, Schulz SC, Sponheim SR, Goff DC, Buka SL, Cherkerzian S, Thermenos HW, Kubicki M, Nestor PG, Dickie EW, Vassos E, Ciufolini S, Reis Marques T, Crossley NA, Purcell SM, Smoller JW, van Haren NEM, Toulopoulou T, Donohoe G, Goldstein JM, Seidman LJ, McCarley RW, Petryshen TL. The Genetics of Endophenotypes of Neurofunction to Understand Schizophrenia (GENUS) consortium: A collaborative cognitive and neuroimaging genetics project. Schizophr Res. 2018 05; 195:306-317. PMID: 28982554.
    Citations: 12     Fields:    Translation:Humans
  46. Holsen LM, Davidson P, Cerit H, Hye T, Moondra P, Haimovici F, Sogg S, Shikora S, Goldstein JM, Evins AE, Stoeckel LE. Neural predictors of 12-month weight loss outcomes following bariatric surgery. Int J Obes (Lond). 2018 04; 42(4):785-793. PMID: 28894291.
    Citations: 16     Fields:    Translation:Humans
  47. Mareckova K, Holsen L, Admon R, Whitfield-Gabrieli S, Seidman LJ, Buka SL, Klibanski A, Goldstein JM. Neural - hormonal responses to negative affective stimuli: Impact of dysphoric mood and sex. J Affect Disord. 2017 11; 222:88-97. PMID: 28688266.
    Citations: 10     Fields:    Translation:Humans
  48. Gilman SE, Hornig M, Ghassabian A, Hahn J, Cherkerzian S, Albert PS, Buka SL, Goldstein JM. Socioeconomic disadvantage, gestational immune activity, and neurodevelopment in early childhood. Proc Natl Acad Sci U S A. 2017 06 27; 114(26):6728-6733. PMID: 28607066.
    Citations: 31     Fields:    Translation:HumansPHPublic HealthCTClinical Trials
  49. Jacobs EG, Weiss B, Makris N, Whitfield-Gabrieli S, Buka SL, Klibanski A, Goldstein JM. Reorganization of Functional Networks in Verbal Working Memory Circuitry in Early Midlife: The Impact of Sex and Menopausal Status. Cereb Cortex. 2017 05 01; 27(5):2857-2870. PMID: 27178194.
    Citations: 23     Fields:    Translation:Humans
  50. Rentz DM, Weiss BK, Jacobs EG, Cherkerzian S, Klibanski A, Remington A, Aizley H, Goldstein JM. Sex differences in episodic memory in early midlife: impact of reproductive aging. Menopause. 2017 04; 24(4):400-408. PMID: 27824681.
    Citations: 40     Fields:    Translation:Humans
  51. Agnew-Blais J, Seidman LJ, Fitzmaurice GM, Smoller JW, Goldstein JM, Buka SL. The interplay of childhood behavior problems and IQ in the development of later schizophrenia and affective psychoses. Schizophr Res. 2017 06; 184:45-51. PMID: 28062262.
    Citations: 3     Fields:    Translation:Humans
  52. Goldstein JM, Holsen L, Huang G, Hammond BD, James-Todd T, Cherkerzian S, Hale TM, Handa RJ. Prenatal stress-immune programming of sex differences in comorbidity of depression and obesity/metabolic syndrome. Dialogues Clin Neurosci. 2016 12; 18(4):425-436. PMID: 28179814.
    Citations: 20     Fields:    Translation:Humans
  53. Del Re EC, Konishi J, Bouix S, Blokland GA, Mesholam-Gately RI, Goldstein J, Kubicki M, Wojcik J, Pasternak O, Seidman LJ, Petryshen T, Hirayasu Y, Niznikiewicz M, Shenton ME, McCarley RW. Enlarged lateral ventricles inversely correlate with reduced corpus callosum central volume in first episode schizophrenia: association with functional measures. Brain Imaging Behav. 2016 12; 10(4):1264-1273. PMID: 26678596.
    Citations: 14     Fields:    Translation:Humans
  54. Mareckova K, Holsen LM, Admon R, Makris N, Seidman L, Buka S, Whitfield-Gabrieli S, Goldstein JM. Brain activity and connectivity in response to negative affective stimuli: Impact of dysphoric mood and sex across diagnoses. Hum Brain Mapp. 2016 11; 37(11):3733-3744. PMID: 27246897.
    Citations: 16     Fields:    Translation:Humans
  55. Jacobs EG, Weiss BK, Makris N, Whitfield-Gabrieli S, Buka SL, Klibanski A, Goldstein JM. Impact of Sex and Menopausal Status on Episodic Memory Circuitry in Early Midlife. J Neurosci. 2016 09 28; 36(39):10163-73. PMID: 27683911.
    Citations: 26     Fields:    Translation:Humans
  56. Gilman SE, Cherkerzian S, Buka SL, Hahn J, Hornig M, Goldstein JM. Prenatal immune programming of the sex-dependent risk for major depression. Transl Psychiatry. 2016 05 31; 6(5):e822. PMID: 27244231.
    Citations: 30     Fields:    Translation:Humans
  57. Seitz J, Zuo JX, Lyall AE, Makris N, Kikinis Z, Bouix S, Pasternak O, Fredman E, Duskin J, Goldstein JM, Petryshen TL, Mesholam-Gately RI, Wojcik J, McCarley RW, Seidman LJ, Shenton ME, Koerte IK, Kubicki M. Tractography Analysis of 5 White Matter Bundles and Their Clinical and Cognitive Correlates in Early-Course Schizophrenia. Schizophr Bull. 2016 May; 42(3):762-71. PMID: 27009248.
    Citations: 21     Fields:    Translation:Humans
  58. Thermenos HW, Juelich RJ, DiChiara SR, Mesholam-Gately RI, Woodberry KA, Wojcik J, Makris N, Keshavan MS, Whitfield-Gabrieli S, Woo TU, Petryshen TL, Goldstein JM, Shenton ME, McCarley RW, Seidman LJ. Hyperactivity of caudate, parahippocampal, and prefrontal regions during working memory in never-medicated persons at clinical high-risk for psychosis. Schizophr Res. 2016 May; 173(1-2):1-12. PMID: 26965745.
    Citations: 7     Fields:    Translation:Humans
  59. Chin-Lun Hung G, Hahn J, Alamiri B, Buka SL, Goldstein JM, Laird N, Nelson CA, Smoller JW, Gilman SE. Socioeconomic disadvantage and neural development from infancy through early childhood. Int J Epidemiol. 2015 Dec; 44(6):1889-99. PMID: 26675752.
    Citations: 28     Fields:    Translation:Humans
  60. Del Re EC, Gao Y, Eckbo R, Petryshen TL, Blokland GA, Seidman LJ, Konishi J, Goldstein JM, McCarley RW, Shenton ME, Bouix S. A New MRI Masking Technique Based on Multi-Atlas Brain Segmentation in Controls and Schizophrenia: A Rapid and Viable Alternative to Manual Masking. J Neuroimaging. 2016 Jan-Feb; 26(1):28-36. PMID: 26585545.
    Citations: 9     Fields:    Translation:Humans
  61. Poggioli T, Vujic A, Yang P, Macias-Trevino C, Uygur A, Loffredo FS, Pancoast JR, Cho M, Goldstein J, Tandias RM, Gonzalez E, Walker RG, Thompson TB, Wagers AJ, Fong YW, Lee RT. Circulating Growth Differentiation Factor 11/8 Levels Decline With Age. Circ Res. 2016 Jan 08; 118(1):29-37. PMID: 26489925.
    Citations: 82     Fields:    Translation:Animals
  62. Goldstein J, Roth E, Roberts N, Zwick R, Lin S, Fletcher S, Tadeu A, Wu C, Beck A, Zeiss C, Suárez-Fariñas M, Horsley V. Loss of endogenous Nfatc1 reduces the rate of DMBA/TPA-induced skin tumorigenesis. Mol Biol Cell. 2015 Oct 15; 26(20):3606-14. PMID: 26310443.
    Citations: 6     Fields:    Translation:AnimalsCells
  63. Ohtani T, Bouix S, Lyall AE, Hosokawa T, Saito Y, Melonakos E, Westin CF, Seidman LJ, Goldstein J, Mesholam-Gately R, Petryshen T, Wojcik J, Kubicki M. Abnormal white matter connections between medial frontal regions predict symptoms in patients with first episode schizophrenia. Cortex. 2015 Oct; 71:264-76. PMID: 26277547.
    Citations: 10     Fields:    Translation:Humans
  64. Canuti M, Buka S, Jazaeri Farsani SM, Oude Munnink BB, Jebbink MF, van Beveren NJ, de Haan L, Goldstein J, Seidman LJ, Tsuang MT, Storosum JG, van der Hoek L. Reduced maternal levels of common viruses during pregnancy predict offspring psychosis: potential role of enhanced maternal immune activity? Schizophr Res. 2015 Aug; 166(1-3):248-54. PMID: 26004694.
    Citations: 4     Fields:    Translation:Humans
  65. Lawson EA, Holsen LM, Santin M, DeSanti R, Meenaghan E, Eddy KT, Herzog DB, Goldstein JM, Klibanski A. Correction: Postprandial oxytocin secretion is associated with severity of anxiety and depressive symptoms in anorexia nervosa. J Clin Psychiatry. 2015 05; 76(5):666. PMID: 26035205.
    Citations:    Fields:    
  66. Agnew-Blais JC, Buka SL, Fitzmaurice GM, Smoller JW, Goldstein JM, Seidman LJ. Early Childhood IQ Trajectories in Individuals Later Developing Schizophrenia and Affective Psychoses in the New England Family Studies. Schizophr Bull. 2015 Jul; 41(4):817-23. PMID: 25904723.
    Citations: 13     Fields:    Translation:Humans
  67. Holsen LM, Goldstein JM. Valuation and cognitive circuitry in anorexia nervosa: disentangling appetite from the effort to obtain a reward. Biol Psychiatry. 2015 Apr 01; 77(7):604-6. PMID: 25766686.
    Citations: 1     Fields:    Translation:Humans
  68. Goldstein JM, Lancaster K, Longenecker JM, Abbs B, Holsen LM, Cherkerzian S, Whitfield-Gabrieli S, Makris N, Tsuang MT, Buka SL, Seidman LJ, Klibanski A. Sex differences, hormones, and fMRI stress response circuitry deficits in psychoses. Psychiatry Res. 2015 Jun 30; 232(3):226-36. PMID: 25914141.
    Citations: 12     Fields:    Translation:Humans
  69. Kikinis Z, Fitzsimmons J, Dunn C, Vu MA, Makris N, Bouix S, Goldstein JM, Mesholam-Gately RI, Petryshen T, Del Re EC, Wojcik J, Seidman LJ, Kubicki M. Anterior commissural white matter fiber abnormalities in first-episode psychosis: a tractography study. Schizophr Res. 2015 Mar; 162(1-3):29-34. PMID: 25667192.
    Citations: 6     Fields:    Translation:Humans
  70. del Re EC, Spencer KM, Oribe N, Mesholam-Gately RI, Goldstein J, Shenton ME, Petryshen T, Seidman LJ, McCarley RW, Niznikiewicz MA. Clinical high risk and first episode schizophrenia: auditory event-related potentials. Psychiatry Res. 2015 Feb 28; 231(2):126-33. PMID: 25557063.
    Citations: 20     Fields:    Translation:Humans
  71. Admon R, Holsen LM, Aizley H, Remington A, Whitfield-Gabrieli S, Goldstein JM, Pizzagalli DA. Striatal Hypersensitivity During Stress in Remitted Individuals with Recurrent Depression. Biol Psychiatry. 2015 Jul 01; 78(1):67-76. PMID: 25483401.
    Citations: 35     Fields:    Translation:Humans
  72. Goldstein JM, Holsen L, Handa R, Tobet S. Fetal hormonal programming of sex differences in depression: linking women's mental health with sex differences in the brain across the lifespan. Front Neurosci. 2014; 8:247. PMID: 25249929.
    Citations: 23     
  73. Fitzsimmons J, Schneiderman JS, Whitford TJ, Swisher T, Niznikiewicz MA, Pelavin PE, Terry DP, Mesholam-Gately RI, Seidman LJ, Goldstein JM, Kubicki M. Cingulum bundle diffusivity and delusions of reference in first episode and chronic schizophrenia. Psychiatry Res. 2014 Nov 30; 224(2):124-32. PMID: 25174840.
    Citations: 11     Fields:    Translation:Humans
  74. Jacobs EG, Holsen LM, Lancaster K, Makris N, Whitfield-Gabrieli S, Remington A, Weiss B, Buka S, Klibanski A, Goldstein JM. 17ß-estradiol differentially regulates stress circuitry activity in healthy and depressed women. Neuropsychopharmacology. 2015 Feb; 40(3):566-76. PMID: 25113601.
    Citations: 29     Fields:    Translation:Humans
  75. Goldstein J, Fletcher S, Roth E, Wu C, Chun A, Horsley V. Calcineurin/Nfatc1 signaling links skin stem cell quiescence to hormonal signaling during pregnancy and lactation. Genes Dev. 2014 Jul 1; 28(13):1515. PMID: 24990968.
    Citations:    
  76. Woodberry KA, Serur RA, Hallinan SB, Mesholam-Gately RI, Giuliano AJ, Wojcik JD, Keshavan MS, Frazier JA, Goldstein JM, Shenton ME, McCarley RW, Seidman LJ. Frequency and pattern of childhood symptom onset reported by first episode schizophrenia and clinical high risk youth. Schizophr Res. 2014 Sep; 158(1-3):45-51. PMID: 24924404.
    Citations: 10     Fields:    Translation:Humans
  77. Oribe N, Hirano Y, Kanba S, Del Re E, Seidman L, Mesholam-Gately R, Goldstein JM, Shenton M, Spencer KM, McCarley RW, Niznikiewicz M. Progressive reduction of visual P300 amplitude in patients with first-episode schizophrenia: an ERP study. Schizophr Bull. 2015 Mar; 41(2):460-70. PMID: 24914176.
    Citations: 9     Fields:    Translation:Humans
  78. Holsen LM, Lawson EA, Christensen K, Klibanski A, Goldstein JM. Abnormal relationships between the neural response to high- and low-calorie foods and endogenous acylated ghrelin in women with active and weight-recovered anorexia nervosa. Psychiatry Res. 2014 Aug 30; 223(2):94-103. PMID: 24862390.
    Citations: 26     Fields:    Translation:HumansCells
  79. Goldstein J, Fletcher S, Roth E, Wu C, Chun A, Horsley V. Calcineurin/Nfatc1 signaling links skin stem cell quiescence to hormonal signaling during pregnancy and lactation. Genes Dev. 2014 May 01; 28(9):983-94. PMID: 24732379.
    Citations: 20     Fields:    Translation:AnimalsCells
  80. Pietersen CY, Mauney SA, Kim SS, Lim MP, Rooney RJ, Goldstein JM, Petryshen TL, Seidman LJ, Shenton ME, McCarley RW, Sonntag KC, Woo TU. Molecular profiles of pyramidal neurons in the superior temporal cortex in schizophrenia. J Neurogenet. 2014 Mar-Jun; 28(1-2):53-69. PMID: 24702465.
    Citations: 35     Fields:    Translation:HumansCells
  81. Goldstein JM, Cherkerzian S, Seidman LJ, Donatelli JA, Remington AG, Tsuang MT, Hornig M, Buka SL. Prenatal maternal immune disruption and sex-dependent risk for psychoses. Psychol Med. 2014 Nov; 44(15):3249-61. PMID: 25065485.
    Citations: 29     Fields:    Translation:Humans
  82. Pietersen CY, Mauney SA, Kim SS, Passeri E, Lim MP, Rooney RJ, Goldstein JM, Petreyshen TL, Seidman LJ, Shenton ME, Mccarley RW, Sonntag KC, Woo TU. Molecular profiles of parvalbumin-immunoreactive neurons in the superior temporal cortex in schizophrenia. J Neurogenet. 2014 Mar-Jun; 28(1-2):70-85. PMID: 24628518.
    Citations: 34     Fields:    Translation:HumansCells
  83. Del Re EC, Bergen SE, Mesholam-Gately RI, Niznikiewicz MA, Goldstein JM, Woo TU, Shenton ME, Seidman LJ, McCarley RW, Petryshen TL. Analysis of schizophrenia-related genes and electrophysiological measures reveals ZNF804A association with amplitude of P300b elicited by novel sounds. Transl Psychiatry. 2014 Jan 14; 4:e346. PMID: 24424392.
    Citations: 14     Fields:    Translation:Humans
  84. Goldstein JM, Handa RJ, Tobet SA. Disruption of fetal hormonal programming (prenatal stress) implicates shared risk for sex differences in depression and cardiovascular disease. Front Neuroendocrinol. 2014 Jan; 35(1):140-58. PMID: 24355523.
    Citations: 34     Fields:    Translation:HumansAnimals
  85. Buka SL, Seidman LJ, Tsuang MT, Goldstein JM. The New England Family Study High-risk Project: neurological impairments among offspring of parents with schizophrenia and other psychoses. Am J Med Genet B Neuropsychiatr Genet. 2013 Oct; 162B(7):653-60. PMID: 24132897.
    Citations: 6     Fields:    Translation:Humans
  86. Lawson EA, Holsen LM, Desanti R, Santin M, Meenaghan E, Herzog DB, Goldstein JM, Klibanski A. Increased hypothalamic-pituitary-adrenal drive is associated with decreased appetite and hypoactivation of food-motivation neurocircuitry in anorexia nervosa. Eur J Endocrinol. 2013 Nov; 169(5):639-47. PMID: 23946275.
    Citations: 20     Fields:    Translation:Humans
  87. Goldstein JM, Cherkerzian S,