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Jill M. Goldstein, Ph.D.

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Other Positions
Title
Institution
Department

Biography
1987 - 1989
Schizophrenia Research Program Award
1989 - 1989
NIMH Young Investigator Award
1989 - 1991
Young Investigator Award for Scientific Research
1990 - 1991
William F. Milton Fund Award for Scientific Research
1991 - 1992
NIMH Clinical Research Fellowship Award in Biological Psychiatry
2002 - 2003
Collaborative Research Award
2005 - 2005
Award for Exploratory Seminar on the “Genetics of Sex Effects in Clinical Medicine”
2007 - 2007
Selected the 2007 Spinoza Professor
2008 - 2008
Award for Exploratory Seminar on “Unexplored Sex Differences in Cardiovascular Disease”

Overview
Introduction: I have had a long-standing interest in sex differences in brain development and their implications for adult brain structure and function, the roles of adrenal and gonadal hormones and genes in understanding these sex differences, and how these factors relate to understanding sex differences in psychiatric disorders. I believe that an understanding of these hormonal and genetic pathways will provide knowledge for the development of novel sex-specific therapeutic discovery for these disorders. In my roles as Director of Research for the Connors Center for Women’s Health and Gender Biology at BWH, P.I. of a Harvard-wide ORWH-NICHD K-award training grant entitled, “Hormones and Genes in Women’s Health: From Bench to Bedside”, in addition to a number of cross-institutional, interdisciplinary grants, I have been working with a team of colleagues that span Harvard schools and departments and outside collaborative institutions that integrate fields of study, methods of analysis, and levels of study from basic to clinical. Little is known about how sex differences in healthy brain development may or may not deviate in producing neuropsychiatric pathology and the impact on treatment. Further, clinical decisions based on research are primarily based on data from males that are often inappropriate for females, even for disorders (like depression) in which women predominate. Given the gap between the clinical and scientific importance of studying sex effects in medicine and the relative paucity of studies on these issues, the history of my work and current team efforts have been to contribute to move this field forward.

History of Research: Schizophrenia is a devastating, costly illness, economically and socially. In the early 1980’s, the prevailing ideology was that schizophrenia was similar in men and women. The assumption was that some women with schizophrenia were misclassified as affective disorder patients. I began my career by demonstrating empirically that sex differences in schizophrenia were not an artifact of diagnosis and one’s sex may provide clues to the illness etiology. For >25 years, I have been investigating the hypothesis that men may be at higher risk for a more severe form of schizophrenia than women. Trained originally as a psychiatric epidemiologist, my work focused on identifying how men and women differed in their symptomatology, premorbid history and age at onset, course, genetic transmission, and incidence.

My team, among others, demonstrated that schizophrenia’s origins are most likely in fetal/perinatal periods of brain development. Thus, I hypothesized that explanatory mechanisms regarding sex differences involved understanding sex differences in brain development. Beginning in 1989, I received NIMH and NARSAD awards to support supplemental training in clinical neuroscience (neuroanatomy and brain imaging) to provide me with the ability to investigate this. My studies of sex differences in cognitive functions resulted in several publications identifying specific domains in which women had relative preservation of function, i.e. language, executive functions, verbal memory, and olfaction. Using sophisticated structural MRI techniques, my team showed that cortical brain regions implicated in the processing of these domains showed sex differences in brain volume in schizophrenia. Further, based on animal studies, the brain regions implicated were rich in gonadal hormone receptors compared with other brain regions. This work suggested that the effects of gonadal hormones on the brain during fetal and/or perinatal development would contribute to understanding sex differences in schizophrenia and normal sex differences in the adult brain, with implications for sex differences in brain function and activity in adulthood. Current studies are focusing on the associations between hormonal dysregulation and brain activity deficits in the stress response circuitry and in memory and working memory in major psychiatric disorders. My research program, called the Clinical Neuroscience Laboratory of Sex Differences in the Brain, has been ongoing for over 20 years (cnl-sd.bwh.harvard.edu; mddscor.bwh.harvard.edu).

Current Studies: My team’s current studies are identifying the role of pre-and perinatal risk factors in understanding differential brain abnormalities in men and women with major psychiatric disorders, such as schizophrenia and affective disorders, the role of gonadal and adrenal hormones and genes in the etiology and functional course of these abnormalities, and better identifying normal sex differences in brain structure and function in order to understand how the brain goes awry differentially in men and women with adult onset psychiatric disorders but whose origins begin during fetal development. I am also investigating the shared fetal antecedents to sex differences in the co-morbidity of psychiatric disorders with general medical disorders, such depression and cardiovascular disease and endocrine dysfunction. My research team consists of an interdisciplinary team of investigators, integrating structural and functional MRI studies, psychophysiological responses, neuroendocrine studies of adrenal and gonadal hormones, inflammatory factors, geneticists, and collaborative efforts with animal investigators of steroid hormones, genes, inflammatory factors, and the brain. Included in this work, I oversee a unique birth cohort study in which subjects have prospective data from pregnancy through their late 40’s, including brain imaging, thus drawing on my combined expertise in epidemiology and clinical neuroscience. This work is contributing to understanding the nature of major psychiatric disorders, the impact of sex, and normal properties of the male and female brain in the face of disease.

Finally, as Director of Research at the Connors-BRI Center, I have been building a research infrastructure at BWH to foster collaborative efforts to understand mechanisms that explain sex differences in health and disease across disciplines and methods of study and to provide a source of knowledge and training for future young scientists and clinicians in women’s health and gender biology.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R56MH113217 (GOLDSTEIN, JILL M) Sep 20, 2017 - Aug 31, 2018
    NIH/NIMH
    Prenatal Immune Programming of Sex Differences in Dysregulation of Emotion Processing in Midlife
    Role: Principal Investigator
  2. R01MH108602 (PIZZAGALLI, DIEGO A) Aug 10, 2016 - Apr 30, 2021
    NIH/NIMH
    Sex, Hormones and GABA in Stress Induced Anhedonia in Depression
    Role: Principal Investigator
  3. R03MH105585 (GOLDSTEIN, JILL M) Jan 1, 2015 - Dec 31, 2016
    NIH/NIMH
    Prenatal & Adult Immune Biomarkers of the Negative Valence Biosignature
    Role: Principal Investigator
  4. R21MH103468 (GOLDSTEIN, JILL M) Sep 26, 2014 - Jul 31, 2016
    NIH/NIMH
    Neural-Physiology Biosignature Shared across Negative Valence and Arousal Domains
    Role: Principal Investigator
  5. R01MH090291 (GOLDSTEIN, JILL M) Jul 1, 2011 - Mar 31, 2016
    NIH/NIMH
    Fetal Hormonal Programming of Sex Differences in Aging of the Memory Circuitry
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Nebel RA, Aggarwal NT, Barnes LL, Gallagher A, Goldstein JM, Kantarci K, Mallampalli MP, Mormino EC, Scott L, Yu WH, Maki PM, Mielke MM. Understanding the impact of sex and gender in Alzheimer's disease: A call to action. Alzheimers Dement. 2018 Jun 12. PMID: 29907423.
    View in: PubMed
  2. Rich-Edwards JW, Kaiser UB, Chen GL, Manson JE, Goldstein J. Sex and Gender Differences Research Design for Basic, Clinical and Population Studies: Essentials for Investigators. Endocr Rev. 2018 Apr 12. PMID: 29668873.
    View in: PubMed
  3. Lyall AE, Savadjiev P, Del Re EC, Seitz J, O'Donnell LJ, Westin CF, Mesholam-Gately RI, Petryshen T, Wojcik JD, Nestor P, Niznikiewicz M, Goldstein J, Seidman LJ, McCarley RW, Shenton ME, Kubicki M. Utilizing Mutual Information Analysis to Explore the Relationship Between Gray and White Matter Structural Pathologies in Schizophrenia. Schizophr Bull. 2018 Apr 03. PMID: 29618096.
    View in: PubMed
  4. Goldstein JM. Impact of Prenatal Stress on Offspring Psychopathology and Comorbidity With General Medicine Later in Life. Biol Psychiatry. 2018 Mar 15. PMID: 29576191.
    View in: PubMed
  5. Ghassabian A, Albert PS, Hornig M, Yeung E, Cherkerzian S, Goldstein RB, Buka SL, Goldstein JM, Gilman SE. Gestational cytokine concentrations and neurocognitive development at 7 years. Transl Psychiatry. 2018 Mar 13; 8(1):64. PMID: 29531226.
    View in: PubMed
  6. Pace LE, Chen GL, Chai J, Goldstein JM, Orton P, Bartz D, Rich-Edwards J, Manson JE, Johnson PA. Advancing Sex- and Gender-Informed Approaches to Health in an Academic Medical Center. Womens Health Issues. 2018 Mar - Apr; 28(2):117-121. PMID: 29249334.
    View in: PubMed
  7. Blokland GAM, Del Re EC, Mesholam-Gately RI, Jovicich J, Trampush JW, Keshavan MS, DeLisi LE, Walters JTR, Turner JA, Malhotra AK, Lencz T, Shenton ME, Voineskos AN, Rujescu D, Giegling I, Kahn RS, Roffman JL, Holt DJ, Ehrlich S, Kikinis Z, Dazzan P, Murray RM, Di Forti M, Lee J, Sim K, Lam M, Wolthusen RPF, de Zwarte SMC, Walton E, Cosgrove D, Kelly S, Maleki N, Osiecki L, Picchioni MM, Bramon E, Russo M, David AS, Mondelli V, Reinders AATS, Falcone MA, Hartmann AM, Konte B, Morris DW, Gill M, Corvin AP, Cahn W, Ho NF, Liu JJ, Keefe RSE, Gollub RL, Manoach DS, Calhoun VD, Schulz SC, Sponheim SR, Goff DC, Buka SL, Cherkerzian S, Thermenos HW, Kubicki M, Nestor PG, Dickie EW, Vassos E, Ciufolini S, Reis Marques T, Crossley NA, Purcell SM, Smoller JW, van Haren NEM, Toulopoulou T, Donohoe G, Goldstein JM, Seidman LJ, McCarley RW, Petryshen TL. The Genetics of Endophenotypes of Neurofunction to Understand Schizophrenia (GENUS) consortium: A collaborative cognitive and neuroimaging genetics project. Schizophr Res. 2018 May; 195:306-317. PMID: 28982554.
    View in: PubMed
  8. Konishi J, Del Re EC, Bouix S, Blokland GAM, Mesholam-Gately R, Woodberry K, Niznikiewicz M, Goldstein J, Hirayasu Y, Petryshen TL, Seidman LJ, Shenton ME, McCarley RW. Abnormal relationships between local and global brain measures in subjects at clinical high risk for psychosis: a pilot study. Brain Imaging Behav. 2017 Aug 16. PMID: 28815390.
    View in: PubMed
  9. Holsen LM, Davidson P, Cerit H, Hye T, Moondra P, Haimovici F, Sogg S, Shikora S, Goldstein JM, Evins AE, Stoeckel LE. Neural predictors of 12-month weight loss outcomes following bariatric surgery. Int J Obes (Lond). 2018 Apr; 42(4):785-793. PMID: 28894291.
    View in: PubMed
  10. Mareckova K, Holsen L, Admon R, Whitfield-Gabrieli S, Seidman LJ, Buka SL, Klibanski A, Goldstein JM. Neural - hormonal responses to negative affective stimuli: Impact of dysphoric mood and sex. J Affect Disord. 2017 11; 222:88-97. PMID: 28688266.
    View in: PubMed
  11. Gilman SE, Hornig M, Ghassabian A, Hahn J, Cherkerzian S, Albert PS, Buka SL, Goldstein JM. Socioeconomic disadvantage, gestational immune activity, and neurodevelopment in early childhood. Proc Natl Acad Sci U S A. 2017 06 27; 114(26):6728-6733. PMID: 28607066.
    View in: PubMed
  12. Jacobs EG, Weiss B, Makris N, Whitfield-Gabrieli S, Buka SL, Klibanski A, Goldstein JM. Reorganization of Functional Networks in Verbal Working Memory Circuitry in Early Midlife: The Impact of Sex and Menopausal Status. Cereb Cortex. 2017 05 01; 27(5):2857-2870. PMID: 27178194.
    View in: PubMed
  13. Rentz DM, Weiss BK, Jacobs EG, Cherkerzian S, Klibanski A, Remington A, Aizley H, Goldstein JM. Sex differences in episodic memory in early midlife: impact of reproductive aging. Menopause. 2017 Apr; 24(4):400-408. PMID: 27824681.
    View in: PubMed
  14. Agnew-Blais J, Seidman LJ, Fitzmaurice GM, Smoller JW, Goldstein JM, Buka SL. The interplay of childhood behavior problems and IQ in the development of later schizophrenia and affective psychoses. Schizophr Res. 2017 06; 184:45-51. PMID: 28062262.
    View in: PubMed
  15. Goldstein JM, Holsen L, Huang G, Hammond BD, James-Todd T, Cherkerzian S, Hale TM, Handa RJ. Prenatal stress-immune programming of sex differences in comorbidity of depression and obesity/metabolic syndrome. Dialogues Clin Neurosci. 2016 12; 18(4):425-436. PMID: 28179814.
    View in: PubMed
  16. Del Re EC, Konishi J, Bouix S, Blokland GA, Mesholam-Gately RI, Goldstein J, Kubicki M, Wojcik J, Pasternak O, Seidman LJ, Petryshen T, Hirayasu Y, Niznikiewicz M, Shenton ME, McCarley RW. Enlarged lateral ventricles inversely correlate with reduced corpus callosum central volume in first episode schizophrenia: association with functional measures. Brain Imaging Behav. 2016 12; 10(4):1264-1273. PMID: 26678596.
    View in: PubMed
  17. Mareckova K, Holsen LM, Admon R, Makris N, Seidman L, Buka S, Whitfield-Gabrieli S, Goldstein JM. Brain activity and connectivity in response to negative affective stimuli: Impact of dysphoric mood and sex across diagnoses. Hum Brain Mapp. 2016 11; 37(11):3733-3744. PMID: 27246897.
    View in: PubMed
  18. Jacobs EG, Weiss BK, Makris N, Whitfield-Gabrieli S, Buka SL, Klibanski A, Goldstein JM. Impact of Sex and Menopausal Status on Episodic Memory Circuitry in Early Midlife. J Neurosci. 2016 09 28; 36(39):10163-73. PMID: 27683911.
    View in: PubMed
  19. Gilman SE, Cherkerzian S, Buka SL, Hahn J, Hornig M, Goldstein JM. Prenatal immune programming of the sex-dependent risk for major depression. Transl Psychiatry. 2016 05 31; 6(5):e822. PMID: 27244231.
    View in: PubMed
  20. Seitz J, Zuo JX, Lyall AE, Makris N, Kikinis Z, Bouix S, Pasternak O, Fredman E, Duskin J, Goldstein JM, Petryshen TL, Mesholam-Gately RI, Wojcik J, McCarley RW, Seidman LJ, Shenton ME, Koerte IK, Kubicki M. Tractography Analysis of 5 White Matter Bundles and Their Clinical and Cognitive Correlates in Early-Course Schizophrenia. Schizophr Bull. 2016 May; 42(3):762-71. PMID: 27009248; PMCID: PMC4838095 [Available on 05/01/17].
  21. Thermenos HW, Juelich RJ, DiChiara SR, Mesholam-Gately RI, Woodberry KA, Wojcik J, Makris N, Keshavan MS, Whitfield-Gabrieli S, Woo TU, Petryshen TL, Goldstein JM, Shenton ME, McCarley RW, Seidman LJ. Hyperactivity of caudate, parahippocampal, and prefrontal regions during working memory in never-medicated persons at clinical high-risk for psychosis. Schizophr Res. 2016 May; 173(1-2):1-12. PMID: 26965745; PMCID: PMC4836956 [Available on 05/01/17].
  22. Chin-Lun Hung G, Hahn J, Alamiri B, Buka SL, Goldstein JM, Laird N, Nelson CA, Smoller JW, Gilman SE. Socioeconomic disadvantage and neural development from infancy through early childhood. Int J Epidemiol. 2015 Dec; 44(6):1889-99. PMID: 26675752; PMCID: PMC4715254 [Available on 12/01/16].
  23. Del Re EC, Gao Y, Eckbo R, Petryshen TL, Blokland GA, Seidman LJ, Konishi J, Goldstein JM, McCarley RW, Shenton ME, Bouix S. A New MRI Masking Technique Based on Multi-Atlas Brain Segmentation in Controls and Schizophrenia: A Rapid and Viable Alternative to Manual Masking. J Neuroimaging. 2016 Jan-Feb; 26(1):28-36. PMID: 26585545.
    View in: PubMed
  24. Poggioli T, Vujic A, Yang P, Macias-Trevino C, Uygur A, Loffredo FS, Pancoast JR, Cho M, Goldstein J, Tandias RM, Gonzalez E, Walker RG, Thompson TB, Wagers AJ, Fong YW, Lee RT. Circulating Growth Differentiation Factor 11/8 Levels Decline With Age. Circ Res. 2016 Jan 08; 118(1):29-37. PMID: 26489925; PMCID: PMC4748736.
  25. Goldstein J, Roth E, Roberts N, Zwick R, Lin S, Fletcher S, Tadeu A, Wu C, Beck A, Zeiss C, Suárez-Fariñas M, Horsley V. Loss of endogenous Nfatc1 reduces the rate of DMBA/TPA-induced skin tumorigenesis. Mol Biol Cell. 2015 Oct 15; 26(20):3606-14. PMID: 26310443; PMCID: PMC4603931.
  26. Ohtani T, Bouix S, Lyall AE, Hosokawa T, Saito Y, Melonakos E, Westin CF, Seidman LJ, Goldstein J, Mesholam-Gately R, Petryshen T, Wojcik J, Kubicki M. Abnormal white matter connections between medial frontal regions predict symptoms in patients with first episode schizophrenia. Cortex. 2015 Oct; 71:264-76. PMID: 26277547; PMCID: PMC4575843 [Available on 10/01/16].
  27. Canuti M, Buka S, Jazaeri Farsani SM, Oude Munnink BB, Jebbink MF, van Beveren NJ, de Haan L, Goldstein J, Seidman LJ, Tsuang MT, Storosum JG, van der Hoek L. Reduced maternal levels of common viruses during pregnancy predict offspring psychosis: potential role of enhanced maternal immune activity? Schizophr Res. 2015 Aug; 166(1-3):248-54. PMID: 26004694.
    View in: PubMed
  28. Agnew-Blais JC, Buka SL, Fitzmaurice GM, Smoller JW, Goldstein JM, Seidman LJ. Early Childhood IQ Trajectories in Individuals Later Developing Schizophrenia and Affective Psychoses in the New England Family Studies. Schizophr Bull. 2015 Jul; 41(4):817-23. PMID: 25904723.
    View in: PubMed
  29. Holsen LM, Goldstein JM. Valuation and cognitive circuitry in anorexia nervosa: disentangling appetite from the effort to obtain a reward. Biol Psychiatry. 2015 Apr 01; 77(7):604-6. PMID: 25766686.
    View in: PubMed
  30. Goldstein JM, Lancaster K, Longenecker JM, Abbs B, Holsen LM, Cherkerzian S, Whitfield-Gabrieli S, Makris N, Tsuang MT, Buka SL, Seidman LJ, Klibanski A. Sex differences, hormones, and fMRI stress response circuitry deficits in psychoses. Psychiatry Res. 2015 Jun 30; 232(3):226-36. PMID: 25914141; PMCID: PMC4439265.
  31. Kikinis Z, Fitzsimmons J, Dunn C, Vu MA, Makris N, Bouix S, Goldstein JM, Mesholam-Gately RI, Petryshen T, Del Re EC, Wojcik J, Seidman LJ, Kubicki M. Anterior commissural white matter fiber abnormalities in first-episode psychosis: a tractography study. Schizophr Res. 2015 Mar; 162(1-3):29-34. PMID: 25667192; PMCID: PMC4339098.
  32. del Re EC, Spencer KM, Oribe N, Mesholam-Gately RI, Goldstein J, Shenton ME, Petryshen T, Seidman LJ, McCarley RW, Niznikiewicz MA. Clinical high risk and first episode schizophrenia: auditory event-related potentials. Psychiatry Res. 2015 Feb 28; 231(2):126-33. PMID: 25557063; PMCID: PMC4314407.
  33. Admon R, Holsen LM, Aizley H, Remington A, Whitfield-Gabrieli S, Goldstein JM, Pizzagalli DA. Striatal Hypersensitivity During Stress in Remitted Individuals with Recurrent Depression. Biol Psychiatry. 2015 Jul 01; 78(1):67-76. PMID: 25483401; PMCID: PMC4383718.
  34. Goldstein JM, Holsen L, Handa R, Tobet S. Fetal hormonal programming of sex differences in depression: linking women's mental health with sex differences in the brain across the lifespan. Front Neurosci. 2014; 8:247. PMID: 25249929; PMCID: PMC4157606.
  35. Fitzsimmons J, Schneiderman JS, Whitford TJ, Swisher T, Niznikiewicz MA, Pelavin PE, Terry DP, Mesholam-Gately RI, Seidman LJ, Goldstein JM, Kubicki M. Cingulum bundle diffusivity and delusions of reference in first episode and chronic schizophrenia. Psychiatry Res. 2014 Nov 30; 224(2):124-32. PMID: 25174840; PMCID: PMC4195812.
  36. Jacobs EG, Holsen LM, Lancaster K, Makris N, Whitfield-Gabrieli S, Remington A, Weiss B, Buka S, Klibanski A, Goldstein JM. 17ß-estradiol differentially regulates stress circuitry activity in healthy and depressed women. Neuropsychopharmacology. 2015 Feb; 40(3):566-76. PMID: 25113601; PMCID: PMC4289944.
  37. Goldstein J, Fletcher S, Roth E, Wu C, Chun A, Horsley V. Calcineurin/Nfatc1 signaling links skin stem cell quiescence to hormonal signaling during pregnancy and lactation. Genes Dev. 2014 Jul 1; 28(13):1515. PMID: 24990968.
    View in: PubMed
  38. Woodberry KA, Serur RA, Hallinan SB, Mesholam-Gately RI, Giuliano AJ, Wojcik JD, Keshavan MS, Frazier JA, Goldstein JM, Shenton ME, McCarley RW, Seidman LJ. Frequency and pattern of childhood symptom onset reported by first episode schizophrenia and clinical high risk youth. Schizophr Res. 2014 Sep; 158(1-3):45-51. PMID: 24924404; PMCID: PMC4207713.
  39. Oribe N, Hirano Y, Kanba S, Del Re E, Seidman L, Mesholam-Gately R, Goldstein JM, Shenton M, Spencer KM, McCarley RW, Niznikiewicz M. Progressive reduction of visual P300 amplitude in patients with first-episode schizophrenia: an ERP study. Schizophr Bull. 2015 Mar; 41(2):460-70. PMID: 24914176; PMCID: PMC4332938.
  40. Holsen LM, Lawson EA, Christensen K, Klibanski A, Goldstein JM. Abnormal relationships between the neural response to high- and low-calorie foods and endogenous acylated ghrelin in women with active and weight-recovered anorexia nervosa. Psychiatry Res. 2014 Aug 30; 223(2):94-103. PMID: 24862390; PMCID: PMC4090258.
  41. Goldstein J, Fletcher S, Roth E, Wu C, Chun A, Horsley V. Calcineurin/Nfatc1 signaling links skin stem cell quiescence to hormonal signaling during pregnancy and lactation. Genes Dev. 2014 May 01; 28(9):983-94. PMID: 24732379; PMCID: PMC4018496.
  42. Pietersen CY, Mauney SA, Kim SS, Lim MP, Rooney RJ, Goldstein JM, Petryshen TL, Seidman LJ, Shenton ME, McCarley RW, Sonntag KC, Woo TU. Molecular profiles of pyramidal neurons in the superior temporal cortex in schizophrenia. J Neurogenet. 2014 Mar-Jun; 28(1-2):53-69. PMID: 24702465; PMCID: PMC4196521.
  43. Goldstein JM, Cherkerzian S, Seidman LJ, Donatelli JA, Remington AG, Tsuang MT, Hornig M, Buka SL. Prenatal maternal immune disruption and sex-dependent risk for psychoses. Psychol Med. 2014 Nov; 44(15):3249-61. PMID: 25065485; PMCID: PMC4477534.
  44. Pietersen CY, Mauney SA, Kim SS, Passeri E, Lim MP, Rooney RJ, Goldstein JM, Petreyshen TL, Seidman LJ, Shenton ME, Mccarley RW, Sonntag KC, Woo TU. Molecular profiles of parvalbumin-immunoreactive neurons in the superior temporal cortex in schizophrenia. J Neurogenet. 2014 Mar-Jun; 28(1-2):70-85. PMID: 24628518; PMCID: PMC4633016.
  45. Del Re EC, Bergen SE, Mesholam-Gately RI, Niznikiewicz MA, Goldstein JM, Woo TU, Shenton ME, Seidman LJ, McCarley RW, Petryshen TL. Analysis of schizophrenia-related genes and electrophysiological measures reveals ZNF804A association with amplitude of P300b elicited by novel sounds. Transl Psychiatry. 2014 Jan 14; 4:e346. PMID: 24424392; PMCID: PMC3905227.
  46. Goldstein JM, Handa RJ, Tobet SA. Disruption of fetal hormonal programming (prenatal stress) implicates shared risk for sex differences in depression and cardiovascular disease. Front Neuroendocrinol. 2014 Jan; 35(1):140-58. PMID: 24355523; PMCID: PMC3917309.
  47. Buka SL, Seidman LJ, Tsuang MT, Goldstein JM. The New England Family Study High-risk Project: neurological impairments among offspring of parents with schizophrenia and other psychoses. Am J Med Genet B Neuropsychiatr Genet. 2013 Oct; 162B(7):653-60. PMID: 24132897.
    View in: PubMed
  48. Lawson EA, Holsen LM, Desanti R, Santin M, Meenaghan E, Herzog DB, Goldstein JM, Klibanski A. Increased hypothalamic-pituitary-adrenal drive is associated with decreased appetite and hypoactivation of food-motivation neurocircuitry in anorexia nervosa. Eur J Endocrinol. 2013 Nov; 169(5):639-47. PMID: 23946275; PMCID: PMC3807591.
  49. Goldstein JM, Cherkerzian S, Tsuang MT, Petryshen TL. Sex differences in the genetic risk for schizophrenia: history of the evidence for sex-specific and sex-dependent effects. Am J Med Genet B Neuropsychiatr Genet. 2013 Oct; 162B(7):698-710. PMID: 24132902.
    View in: PubMed
  50. Faraone SV, Seidman LJ, Buka S, Goldstein JM, Lyons M, Kremen WS, Glatt SJ. Festschrift celebrating the career of Ming T. Tsuang. Am J Med Genet B Neuropsychiatr Genet. 2013 Oct; 162B(7):551-8. PMID: 24132890.
    View in: PubMed
  51. Gamma F, Goldstein JM, Seidman LJ, Fitzmaurice GM, Tsuang MT, Buka SL. Early intermodal integration in offspring of parents with psychosis. Schizophr Bull. 2014 Sep; 40(5):992-1000. PMID: 23986303; PMCID: PMC4133655.
  52. Holsen LM, Lancaster K, Klibanski A, Whitfield-Gabrieli S, Cherkerzian S, Buka S, Goldstein JM. HPA-axis hormone modulation of stress response circuitry activity in women with remitted major depression. Neuroscience. 2013 Oct 10; 250:733-42. PMID: 23891965; PMCID: PMC3772711.
  53. Lennerz BS, Alsop DC, Holsen LM, Stern E, Rojas R, Ebbeling CB, Goldstein JM, Ludwig DS. Effects of dietary glycemic index on brain regions related to reward and craving in men. Am J Clin Nutr. 2013 Sep; 98(3):641-7. PMID: 23803881; PMCID: PMC3743729.
  54. von Hohenberg CC, Pasternak O, Kubicki M, Ballinger T, Vu MA, Swisher T, Green K, Giwerc M, Dahlben B, Goldstein JM, Woo TU, Petryshen TL, Mesholam-Gately RI, Woodberry KA, Thermenos HW, Mulert C, McCarley RW, Seidman LJ, Shenton ME. White matter microstructure in individuals at clinical high risk of psychosis: a whole-brain diffusion tensor imaging study. Schizophr Bull. 2014 Jul; 40(4):895-903. PMID: 23737549; PMCID: PMC4059424.
  55. Lawson EA, Holsen LM, Santin M, DeSanti R, Meenaghan E, Eddy KT, Herzog DB, Goldstein JM, Klibanski A. Postprandial oxytocin secretion is associated with severity of anxiety and depressive symptoms in anorexia nervosa. J Clin Psychiatry. 2013 May; 74(5):e451-7. PMID: 23759466; PMCID: PMC3731039.
  56. Tobet SA, Handa RJ, Goldstein JM. Sex-dependent pathophysiology as predictors of comorbidity of major depressive disorder and cardiovascular disease. Pflugers Arch. 2013 May; 465(5):585-94. PMID: 23503726; PMCID: PMC3654035.
  57. Quan M, Lee SH, Kubicki M, Kikinis Z, Rathi Y, Seidman LJ, Mesholam-Gately RI, Goldstein JM, McCarley RW, Shenton ME, Levitt JJ. White matter tract abnormalities between rostral middle frontal gyrus, inferior frontal gyrus and striatum in first-episode schizophrenia. Schizophr Res. 2013 Apr; 145(1-3):1-10. PMID: 23415471; PMCID: PMC4110910.
  58. Lee SH, Kubicki M, Asami T, Seidman LJ, Goldstein JM, Mesholam-Gately RI, McCarley RW, Shenton ME. Extensive white matter abnormalities in patients with first-episode schizophrenia: a Diffusion Tensor Iimaging (DTI) study. Schizophr Res. 2013 Feb; 143(2-3):231-8. PMID: 23290268; PMCID: PMC4354799.
  59. Mertz AF, Che Y, Banerjee S, Goldstein JM, Rosowski KA, Revilla SF, Niessen CM, Marchetti MC, Dufresne ER, Horsley V. Cadherin-based intercellular adhesions organize epithelial cell-matrix traction forces. Proc Natl Acad Sci U S A. 2013 Jan 15; 110(3):842-7. PMID: 23277553; PMCID: PMC3549115.
  60. Makris N, Swaab DF, van der Kouwe A, Abbs B, Boriel D, Handa RJ, Tobet S, Goldstein JM. Volumetric parcellation methodology of the human hypothalamus in neuroimaging: normative data and sex differences. Neuroimage. 2013 Apr 01; 69:1-10. PMID: 23247186; PMCID: PMC3575213.
  61. Pasternak O, Westin CF, Bouix S, Seidman LJ, Goldstein JM, Woo TU, Petryshen TL, Mesholam-Gately RI, McCarley RW, Kikinis R, Shenton ME, Kubicki M. Excessive extracellular volume reveals a neurodegenerative pattern in schizophrenia onset. J Neurosci. 2012 Nov 28; 32(48):17365-72. PMID: 23197727; PMCID: PMC3549332.
  62. Holsen LM, Lawson EA, Blum J, Ko E, Makris N, Fazeli PK, Klibanski A, Goldstein JM. Food motivation circuitry hypoactivation related to hedonic and nonhedonic aspects of hunger and satiety in women with active anorexia nervosa and weight-restored women with anorexia nervosa. J Psychiatry Neurosci. 2012 Sep; 37(5):322-32. PMID: 22498079; PMCID: PMC3447131.
  63. Lawson EA, Holsen LM, Santin M, Meenaghan E, Eddy KT, Becker AE, Herzog DB, Goldstein JM, Klibanski A. Oxytocin secretion is associated with severity of disordered eating psychopathology and insular cortex hypoactivation in anorexia nervosa. J Clin Endocrinol Metab. 2012 Oct; 97(10):E1898-908. PMID: 22872688; PMCID: PMC3674290.
  64. Seidman LJ, Cherkerzian S, Goldstein JM, Agnew-Blais J, Tsuang MT, Buka SL. Neuropsychological performance and family history in children at age 7 who develop adult schizophrenia or bipolar psychosis in the New England Family Studies. Psychol Med. 2013 Jan; 43(1):119-31. PMID: 22575089; PMCID: PMC3682767.
  65. Seidman LJ, Meyer EC, Giuliano AJ, Breiter HC, Goldstein JM, Kremen WS, Thermenos HW, Toomey R, Stone WS, Tsuang MT, Faraone SV. Auditory working memory impairments in individuals at familial high risk for schizophrenia. Neuropsychology. 2012 May; 26(3):288-303. PMID: 22563872.
    View in: PubMed
  66. Lebron-Milad K, Abbs B, Milad MR, Linnman C, Rougemount-Bücking A, Zeidan MA, Holt DJ, Goldstein JM. Sex differences in the neurobiology of fear conditioning and extinction: a preliminary fMRI study of shared sex differences with stress-arousal circuitry. Biol Mood Anxiety Disord. 2012 Apr 16; 2:7. PMID: 22738021; PMCID: PMC3416700.
  67. Goldstein J, Horsley V. Home sweet home: skin stem cell niches. Cell Mol Life Sci. 2012 Aug; 69(15):2573-82. PMID: 22410738; PMCID: PMC3449145.
  68. Holsen LM, Lee JH, Spaeth SB, Ogden LA, Klibanski A, Whitfield-Gabrieli S, Sloan RP, Goldstein JM. Brain hypoactivation, autonomic nervous system dysregulation, and gonadal hormones in depression: a preliminary study. Neurosci Lett. 2012 Apr 11; 514(1):57-61. PMID: 22395084; PMCID: PMC3319257.
  69. Goldstein JM, Cherkerzian S, Buka SL, Fitzmaurice G, Hornig M, Gillman M, O'Toole S, Sloan RP. Sex-specific impact of maternal-fetal risk factors on depression and cardiovascular risk 40 years later. J Dev Orig Health Dis. 2011 Dec; 2(6):353-64. PMID: 23378891; PMCID: PMC3558934.
  70. Susser E, Buka SL, Schaefer CA, Andrews H, Cirillo PM, Factor-Litvak P, Gillman M, Goldstein JM, Ivey Henry P, Lumey LH, McKeague IW, Michels KB, Terry MB, Cohn BA. J DoHad. The Early Determinants of Adult Health Study. 2011; (In Press).
  71. Holsen LM, Savage CR, Martin LE, Bruce AS, Lepping RJ, Ko E, Brooks WM, Butler MG, Zarcone JR, Goldstein JM. Importance of reward and prefrontal circuitry in hunger and satiety: Prader-Willi syndrome vs simple obesity. Int J Obes (Lond). 2012 May; 36(5):638-47. PMID: 22024642; PMCID: PMC3270121.
  72. Zeidan MA, Igoe SA, Linnman C, Vitalo A, Levine JB, Klibanski A, Goldstein JM, Milad MR. Estradiol modulates medial prefrontal cortex and amygdala activity during fear extinction in women and female rats. Biol Psychiatry. 2011 Nov 15; 70(10):920-7. PMID: 21762880; PMCID: PMC3197763.
  73. Factor-Litvak P, Strakal N, Cherkerzian S, Richards M, Liu X, Sher A, Neils G, Buka S, Susser E, Goldstein JM. J DOHaD. Associations between fetal inflammation and cognitive functions in middle aged adults. 2011; (In Process).
  74. Goldstein, JM, Cherkerzian, S, Buka, S, Fitzmaurice, G, Susser, E, Hornig, M, Gillman, M, Factor-Litvak, P, Sloan, RP. Sex-specific impact of maternal-fetal risk factors on depression and cardiovascular risk 40 years later. 2011.
  75. Abbs B, Liang L, Makris N, Tsuang M, Seidman LJ, Goldstein JM. Covariance modeling of MRI brain volumes in memory circuitry in schizophrenia: Sex differences are critical. Neuroimage. 2011 Jun 15; 56(4):1865-74. PMID: 21497198; PMCID: PMC3113542.
  76. Milanovic SM, Thermenos HW, Goldstein JM, Brown A, Gabrieli SW, Makris N, Tsuang MT, Buka SL, Seidman LJ. Medial prefrontal cortical activation during working memory differentiates schizophrenia and bipolar psychotic patients: a pilot FMRI study. Schizophr Res. 2011 Jul; 129(2-3):208-10. PMID: 21440419; PMCID: PMC3775485.
  77. Goldstein JM, Cherkerzian S, Seidman LJ, Petryshen TL, Fitzmaurice G, Tsuang MT, Buka SL. Sex-specific rates of transmission of psychosis in the New England high-risk family study. Schizophr Res. 2011 May; 128(1-3):150-5. PMID: 21334180; PMCID: PMC3085650.
  78. Anastario M, Salafia CM, Fitzmaurice G, Goldstein JM. Impact of fetal versus perinatal hypoxia on sex differences in childhood outcomes: developmental timing matters. Soc Psychiatry Psychiatr Epidemiol. 2012 Mar; 47(3):455-64. PMID: 21327969; PMCID: PMC3715145.
  79. Rathi Y, Kubicki M, Bouix S, Westin CF, Goldstein J, Seidman L, Mesholam-Gately R, McCarley RW, Shenton ME. Statistical analysis of fiber bundles using multi-tensor tractography: application to first-episode schizophrenia. Magn Reson Imaging. 2011 May; 29(4):507-15. PMID: 21277725; PMCID: PMC3078978.
  80. Susser E, Buka S, Schaefer CA, Andrews H, Cirillo PM, Factor-Litvak P, Gillman M, Goldstein JM, Henry PI, Lumey LH, McKeague IW, Michels KB, Terry MB, Cohn BA. The Early Determinants of Adult Health Study. J Dev Orig Health Dis. 2011; 2(6):311-321. PMID: 25126404.
    View in: PubMed
  81. Holsen LM, Spaeth SB, Lee JH, Ogden LA, Klibanski A, Whitfield-Gabrieli S, Goldstein JM. Stress response circuitry hypoactivation related to hormonal dysfunction in women with major depression. J Affect Disord. 2011 Jun; 131(1-3):379-87. PMID: 21183223; PMCID: PMC3073153.
  82. Donatelli JA, Seidman LJ, Goldstein JM, Tsuang MT, Buka SL. Children of parents with affective and nonaffective psychoses: a longitudinal study of behavior problems. Am J Psychiatry. 2010 Nov; 167(11):1331-8. PMID: 20843870; PMCID: PMC3684627.
  83. Bale TL, Baram TZ, Brown AS, Goldstein JM, Insel TR, McCarthy MM, Nemeroff CB, Reyes TM, Simerly RB, Susser ES, Nestler EJ. Early life programming and neurodevelopmental disorders. Biol Psychiatry. 2010 Aug 15; 68(4):314-9. PMID: 20674602; PMCID: PMC3168778.
  84. Makris N, Seidman LJ, Ahern T, Kennedy DN, Caviness VS, Tsuang MT, Goldstein JM. White matter volume abnormalities and associations with symptomatology in schizophrenia. Psychiatry Res. 2010 Jul 30; 183(1):21-9. PMID: 20538438; PMCID: PMC2913317.
  85. Goldstein JM, Buka SL, Seidman LJ, Tsuang MT. Specificity of familial transmission of schizophrenia psychosis spectrum and affective psychoses in the New England family study's high-risk design. Arch Gen Psychiatry. 2010 May; 67(5):458-67. PMID: 20439827; PMCID: PMC3049996.
  86. Milad MR, Zeidan MA, Contero A, Pitman RK, Klibanski A, Rauch SL, Goldstein JM. The influence of gonadal hormones on conditioned fear extinction in healthy humans. Neuroscience. 2010 Jul 14; 168(3):652-8. PMID: 20412837; PMCID: PMC2881679.
  87. Goldstein JM, Jerram M, Abbs B, Whitfield-Gabrieli S, Makris N. Sex differences in stress response circuitry activation dependent on female hormonal cycle. J Neurosci. 2010 Jan 13; 30(2):431-8. PMID: 20071507; PMCID: PMC2827936.
  88. Thermenos HW, Goldstein JM, Milanovic SM, Whitfield-Gabrieli S, Makris N, Laviolette P, Koch JK, Faraone SV, Tsuang MT, Buka SL, Seidman LJ. An fMRI study of working memory in persons with bipolar disorder or at genetic risk for bipolar disorder. Am J Med Genet B Neuropsychiatr Genet. 2010 Jan 05; 153B(1):120-31. PMID: 19418510; PMCID: PMC3762486.
  89. Rathi Y, Malcolm J, Michailovich O, Goldstein J, Seidman L, McCarley RW, Westin CF, Shenton ME. Biomarkers for identifying first-episode schizophrenia patients using diffusion weighted imaging. Med Image Comput Comput Assist Interv. 2010; 13(Pt 1):657-65. PMID: 20879287; PMCID: PMC3091029.
  90. Abel KM, Drake R, Goldstein JM. Sex differences in schizophrenia. Int Rev Psychiatry. 2010; 22(5):417-28. PMID: 21047156.
    View in: PubMed
  91. Torrey EF, Buka S, Cannon TD, Goldstein JM, Seidman LJ, Liu T, Hadley T, Rosso IM, Bearden C, Yolken RH. Paternal age as a risk factor for schizophrenia: how important is it? Schizophr Res. 2009 Oct; 114(1-3):1-5. PMID: 19683417.
    View in: PubMed
  92. Hultgren S, Goldstein JM, Delancey JO, Bandstra ES, Brady KT, Brown JS, Deng HW, Dunaif A, Ehrmann DA, Mayer EA, Sinha R, Tobet S, Levine JE. The vital role of ORWH. Science. 2009 Feb 20; 323(5917):1009-10. PMID: 19229019.
    View in: PubMed
  93. Opler MG, Buka SL, Groeger J, McKeague I, Wei C, Factor-Litvak P, Bresnahan M, Graziano J, Goldstein JM, Seidman LJ, Brown AS, Susser ES. Prenatal exposure to lead, delta-aminolevulinic acid, and schizophrenia: further evidence. Environ Health Perspect. 2008 Nov; 116(11):1586-90. PMID: 19057716; PMCID: PMC2592283.
  94. Biederman J, Makris N, Valera EM, Monuteaux MC, Goldstein JM, Buka S, Boriel DL, Bandyopadhyay S, Kennedy DN, Caviness VS, Bush G, Aleardi M, Hammerness P, Faraone SV, Seidman LJ. Towards further understanding of the co-morbidity between attention deficit hyperactivity disorder and bipolar disorder: a MRI study of brain volumes. Psychol Med. 2008 Jul; 38(7):1045-56. PMID: 17935640.
    View in: PubMed
  95. Seidman LJ, Thermenos HW, Koch JK, Ward M, Breiter H, Goldstein JM, Goodman JM, Faraone SV, Tsuang MT. Auditory verbal working memory load and thalamic activation in nonpsychotic relatives of persons with schizophrenia: an fMRI replication. Neuropsychology. 2007 Sep; 21(5):599-610. PMID: 17784808.
    View in: PubMed
  96. Walder DJ, Seidman LJ, Makris N, Tsuang MT, Kennedy DN, Goldstein JM. Neuroanatomic substrates of sex differences in language dysfunction in schizophrenia: a pilot study. Schizophr Res. 2007 Feb; 90(1-3):295-301. PMID: 17150336; PMCID: PMC1894895.
  97. Milad MR, Goldstein JM, Orr SP, Wedig MM, Klibanski A, Pitman RK, Rauch SL. Fear conditioning and extinction: influence of sex and menstrual cycle in healthy humans. Behav Neurosci. 2006 Dec; 120(6):1196-203. PMID: 17201462.
    View in: PubMed
  98. Goldstein JM, Seidman LJ, Makris N, Ahern T, O'Brien LM, Caviness VS, Kennedy DN, Faraone SV, Tsuang MT. Hypothalamic abnormalities in schizophrenia: sex effects and genetic vulnerability. Biol Psychiatry. 2007 Apr 15; 61(8):935-45. PMID: 17046727.
    View in: PubMed
  99. Goldstein JM. Sex, hormones and affective arousal circuitry dysfunction in schizophrenia. Horm Behav. 2006 Nov; 50(4):612-22. PMID: 16876167.
    View in: PubMed
  100. O'Brien LM, Ziegler DA, Deutsch CK, Kennedy DN, Goldstein JM, Seidman LJ, Hodge S, Makris N, Caviness V, Frazier JA, Herbert MR. Adjustment for whole brain and cranial size in volumetric brain studies: a review of common adjustment factors and statistical methods. Harv Rev Psychiatry. 2006 May-Jun; 14(3):141-51. PMID: 16787886.
    View in: PubMed
  101. Walder DJ, Seidman LJ, Cullen N, Su J, Tsuang MT, Goldstein JM. Sex differences in language dysfunction in schizophrenia. Am J Psychiatry. 2006 Mar; 163(3):470-7. PMID: 16513869.
    View in: PubMed
  102. Seidman LJ, Buka SL, Goldstein JM, Tsuang MT. Intellectual decline in schizophrenia: evidence from a prospective birth cohort 28 year follow-up study. J Clin Exp Neuropsychol. 2006 Feb; 28(2):225-42. PMID: 16484095.
    View in: PubMed
  103. Makris N, Goldstein JM, Kennedy D, Hodge SM, Caviness VS, Faraone SV, Tsuang MT, Seidman LJ. Decreased volume of left and total anterior insular lobule in schizophrenia. Schizophr Res. 2006 Apr; 83(2-3):155-71. PMID: 16448806.
    View in: PubMed
  104. Wolfe J, Turner K, Caulfield M, Newton TL, Melia K, Martin J, Goldstein J. Gender and trauma as predictors of military attrition: a study of Marine Corps recruits. Mil Med. 2005 Dec; 170(12):1037-43. PMID: 16491944.
    View in: PubMed
  105. Goldstein JM, Jerram M, Poldrack R, Ahern T, Kennedy DN, Seidman LJ, Makris N. Hormonal cycle modulates arousal circuitry in women using functional magnetic resonance imaging. J Neurosci. 2005 Oct 05; 25(40):9309-16. PMID: 16207891.
    View in: PubMed
  106. Goldstein JM, Jerram M, Poldrack R, Anagnoson R, Breiter HC, Makris N, Goodman JM, Tsuang MT, Seidman LJ. Sex differences in prefrontal cortical brain activity during fMRI of auditory verbal working memory. Neuropsychology. 2005 Jul; 19(4):509-19. PMID: 16060826.
    View in: PubMed
  107. Thermenos HW, Goldstein JM, Buka SL, Poldrack RA, Koch JK, Tsuang MT, Seidman LJ. The effect of working memory performance on functional MRI in schizophrenia. Schizophr Res. 2005 May 01; 74(2-3):179-94. PMID: 15721998.
    View in: PubMed
  108. Buka SL, Goldstein JM, Spartos E, Tsuang MT. The retrospective measurement of prenatal and perinatal events: accuracy of maternal recall. Schizophr Res. 2004 Dec 01; 71(2-3):417-26. PMID: 15474913.
    View in: PubMed
  109. Makris N, Gasic GP, Seidman LJ, Goldstein JM, Gastfriend DR, Elman I, Albaugh MD, Hodge SM, Ziegler DA, Sheahan FS, Caviness VS, Tsuang MT, Kennedy DN, Hyman SE, Rosen BR, Breiter HC. Decreased absolute amygdala volume in cocaine addicts. Neuron. 2004 Nov 18; 44(4):729-40. PMID: 15541319.
    View in: PubMed
  110. Thermenos HW, Seidman LJ, Breiter H, Goldstein JM, Goodman JM, Poldrack R, Faraone SV, Tsuang MT. Functional magnetic resonance imaging during auditory verbal working memory in nonpsychotic relatives of persons with schizophrenia: a pilot study. Biol Psychiatry. 2004 Mar 01; 55(5):490-500. PMID: 15023577.
    View in: PubMed
  111. Fischl B, van der Kouwe A, Destrieux C, Halgren E, Ségonne F, Salat DH, Busa E, Seidman LJ, Goldstein J, Kennedy D, Caviness V, Makris N, Rosen B, Dale AM. Automatically parcellating the human cerebral cortex. Cereb Cortex. 2004 Jan; 14(1):11-22. PMID: 14654453.
    View in: PubMed
  112. Rosas HD, Koroshetz WJ, Chen YI, Skeuse C, Vangel M, Cudkowicz ME, Caplan K, Marek K, Seidman LJ, Makris N, Jenkins BG, Goldstein JM. Evidence for more widespread cerebral pathology in early HD: an MRI-based morphometric analysis. Neurology. 2003 May 27; 60(10):1615-20. PMID: 12771251.
    View in: PubMed
  113. Faraone SV, Seidman LJ, Kremen WS, Kennedy D, Makris N, Caviness VS, Goldstein J, Tsuang MT. Structural brain abnormalities among relatives of patients with schizophrenia: implications for linkage studies. Schizophr Res. 2003 Apr 01; 60(2-3):125-40. PMID: 12591577.
    View in: PubMed
  114. Chengappa KN, Goldstein JM, Greenwood M, John V, Levine J. A post hoc analysis of the impact on hostility and agitation of quetiapine and haloperidol among patients with schizophrenia. Clin Ther. 2003 Feb; 25(2):530-41. PMID: 12749512.
    View in: PubMed
  115. Seidman LJ, Pantelis C, Keshavan MS, Faraone SV, Goldstein JM, Horton NJ, Makris N, Falkai P, Caviness VS, Tsuang MT. A review and new report of medial temporal lobe dysfunction as a vulnerability indicator for schizophrenia: a magnetic resonance imaging morphometric family study of the parahippocampal gyrus. Schizophr Bull. 2003; 29(4):803-30. PMID: 14989416.
    View in: PubMed
  116. Seidman LJ, Faraone SV, Goldstein JM, Kremen WS, Horton NJ, Makris N, Toomey R, Kennedy D, Caviness VS, Tsuang MT. Left hippocampal volume as a vulnerability indicator for schizophrenia: a magnetic resonance imaging morphometric study of nonpsychotic first-degree relatives. Arch Gen Psychiatry. 2002 Sep; 59(9):839-49. PMID: 12215084.
    View in: PubMed
  117. Canuso CM, Goldstein JM, Wojcik J, Dawson R, Brandman D, Klibanski A, Schildkraut JJ, Green AI. Antipsychotic medication, prolactin elevation, and ovarian function in women with schizophrenia and schizoaffective disorder. Psychiatry Res. 2002 Aug 05; 111(1):11-20. PMID: 12140115.
    View in: PubMed
  118. Goldstein JM, Cohen LS, Horton NJ, Lee H, Andersen S, Tohen M, Crawford A, Tollefson G. Sex differences in clinical response to olanzapine compared with haloperidol. Psychiatry Res. 2002 May 15; 110(1):27-37. PMID: 12007591.
    View in: PubMed
  119. Goldstein JM. Your recall program: is it as productive as it could be? J Calif Dent Assoc. 2002 Mar; 30(3):239-43. PMID: 12002255.
    View in: PubMed
  120. Goldstein JM, Seidman LJ, O'Brien LM, Horton NJ, Kennedy DN, Makris N, Caviness VS, Faraone SV, Tsuang MT. Impact of normal sexual dimorphisms on sex differences in structural brain abnormalities in schizophrenia assessed by magnetic resonance imaging. Arch Gen Psychiatry. 2002 Feb; 59(2):154-64. PMID: 11825137.
    View in: PubMed
  121. Seidman LJ, Kremen WS, Koren D, Faraone SV, Goldstein JM, Tsuang MT. A comparative profile analysis of neuropsychological functioning in patients with schizophrenia and bipolar psychoses. Schizophr Res. 2002 Jan 01; 53(1-2):31-44. PMID: 11728836.
    View in: PubMed
  122. Goldstein JM, Seidman LJ, Horton NJ, Makris N, Kennedy DN, Caviness VS, Faraone SV, Tsuang MT. Normal sexual dimorphism of the adult human brain assessed by in vivo magnetic resonance imaging. Cereb Cortex. 2001 Jun; 11(6):490-7. PMID: 11375910.
    View in: PubMed
  123. Paul RH, Nash JM, Cohen RA, Gilchrist JM, Goldstein JM. Quality of life and well-being of patients with myasthenia gravis. Muscle Nerve. 2001 Apr; 24(4):512-6. PMID: 11268023.
    View in: PubMed
  124. Goldstein JM. The new generation of antipsychotic drugs: how atypical are they? Int J Neuropsychopharmacol. 2000 Dec; 3(4):339-349. PMID: 11343614.
    View in: PubMed
  125. Paul RH, Cohen RA, Gilchrist JM, Aloia MS, Goldstein JM. Cognitive dysfunction in individuals with myasthenia gravis. J Neurol Sci. 2000 Oct 01; 179(S 1-2):59-64. PMID: 11054486.
    View in: PubMed
  126. Goldstein JM, Brecher M. Clarification of anticholinergic effects of quetiapine. J Clin Psychiatry. 2000 Sep; 61(9):680. PMID: 11030492.
    View in: PubMed
  127. Paul RH, Cohen RA, Goldstein JM, Gilchrist JM. Fatigue and its impact on patients with myasthenia gravis. Muscle Nerve. 2000 Sep; 23(9):1402-6. PMID: 10951443.
    View in: PubMed
  128. Fucetola R, Seidman LJ, Kremen WS, Faraone SV, Goldstein JM, Tsuang MT. Age and neuropsychologic function in schizophrenia: a decline in executive abilities beyond that observed in healthy volunteers. Biol Psychiatry. 2000 Jul 15; 48(2):137-46. PMID: 10903410.
    View in: PubMed
  129. Goldstein JM, Seidman LJ, Buka SL, Horton NJ, Donatelli JL, Rieder RO, Tsuang MT. Impact of genetic vulnerability and hypoxia on overall intelligence by age 7 in offspring at high risk for schizophrenia compared with affective psychoses. Schizophr Bull. 2000; 26(2):323-34. PMID: 10885634.
    View in: PubMed
  130. Seidman LJ, Buka SL, Goldstein JM, Horton NJ, Rieder RO, Tsuang MT. The relationship of prenatal and perinatal complications to cognitive functioning at age 7 in the New England Cohorts of the National Collaborative Perinatal Project. Schizophr Bull. 2000; 26(2):309-21. PMID: 10885633.
    View in: PubMed
  131. Buka SL, Goldstein JM, Seidman LJ, Tsuang MT. Maternal recall of pregnancy history: accuracy and bias in schizophrenia research. Schizophr Bull. 2000; 26(2):335-50. PMID: 10885635.
    View in: PubMed
  132. Seidman LJ, Faraone SV, Goldstein JM, Goodman JM, Kremen WS, Toomey R, Tourville J, Kennedy D, Makris N, Caviness VS, Tsuang MT. Thalamic and amygdala-hippocampal volume reductions in first-degree relatives of patients with schizophrenia: an MRI-based morphometric analysis. Biol Psychiatry. 1999 Oct 01; 46(7):941-54. PMID: 10509177.
    View in: PubMed
  133. Goldstein JM, Goodman JM, Seidman LJ, Kennedy DN, Makris N, Lee H, Tourville J, Caviness VS, Faraone SV, Tsuang MT. Cortical abnormalities in schizophrenia identified by structural magnetic resonance imaging. Arch Gen Psychiatry. 1999 Jun; 56(6):537-47. PMID: 10359468.
    View in: PubMed
  134. Goldstein JM, Kennedy DN, Caviness VS. Images in neuroscience. Brain development, XI: sexual dimorphism. Am J Psychiatry. 1999 Mar; 156(3):352. PMID: 10080547.
    View in: PubMed
  135. Goldstein JM. Quetiapine fumarate (Seroquel): a new atypical antipsychotic. Drugs Today (Barc). 1999 Mar; 35(3):193-210. PMID: 12973385.
    View in: PubMed
  136. Goldstein JM. One important way to get the best performance from staff. J Calif Dent Assoc. 1999 Mar; 27(3):238-44. PMID: 10634128.
    View in: PubMed
  137. Goldstein JM. Inaccurate information on quetiapine. J Clin Psychiatry. 1998 Dec; 59(12):687. PMID: 9921704.
    View in: PubMed
  138. Seidman LJ, Van Manen KJ, Turner WM, Gamser DM, Faraone SV, Goldstein JM, Tsuang MT. The effects of increasing resource demand on vigilance performance in adults with schizophrenia or developmental attentional/learning disorders: a preliminary study. Schizophr Res. 1998 Nov 09; 34(1-2):101-12. PMID: 9824882.
    View in: PubMed
  139. Seidman LJ, Breiter HC, Goodman JM, Goldstein JM, Woodruff PW, O'Craven K, Savoy R, Tsuang MT, Rosen BR. A functional magnetic resonance imaging study of auditory vigilance with low and high information processing demands. Neuropsychology. 1998 Oct; 12(4):505-18. PMID: 9805320.
    View in: PubMed
  140. Goldstein JM, Seidman LJ, Goodman JM, Koren D, Lee H, Weintraub S, Tsuang MT. Are there sex differences in neuropsychological functions among patients with schizophrenia? Am J Psychiatry. 1998 Oct; 155(10):1358-64. PMID: 9766767.
    View in: PubMed
  141. Portas CM, Goldstein JM, Shenton ME, Hokama HH, Wible CG, Fischer I, Kikinis R, Donnino R, Jolesz FA, McCarley RW. Volumetric evaluation of the thalamus in schizophrenic male patients using magnetic resonance imaging. Biol Psychiatry. 1998 May 01; 43(9):649-59. PMID: 9582998.
    View in: PubMed
  142. Kremen WS, Buka SL, Seidman LJ, Goldstein JM, Koren D, Tsuang MT. IQ decline during childhood and adult psychotic symptoms in a community sample: a 19-year longitudinal study. Am J Psychiatry. 1998 May; 155(5):672-7. PMID: 9585720.
    View in: PubMed
  143. Koren D, Seidman LJ, Harrison RH, Lyons MJ, Kremen WS, Caplan B, Goldstein JM, Faraone SV, Tsuang MT. Factor structure of the Wisconsin Card Sorting Test: dimensions of deficit in schizophrenia. Neuropsychology. 1998 Apr; 12(2):289-302. PMID: 9556775.
    View in: PubMed
  144. Canuso CM, Goldstein JM, Green AI. The evaluation of women with schizophrenia. Psychopharmacol Bull. 1998; 34(3):271-7. PMID: 9803753.
    View in: PubMed
  145. Seidman LJ, Faraone SV, Goldstein JM, Goodman JM, Kremen WS, Matsuda G, Hoge EA, Kennedy D, Makris N, Caviness VS, Tsuang MT. Reduced subcortical brain volumes in nonpsychotic siblings of schizophrenic patients: a pilot magnetic resonance imaging study. Am J Med Genet. 1997 Sep 19; 74(5):507-14. PMID: 9342202.
    View in: PubMed
  146. Seidman LJ, Goldstein JM, Goodman JM, Koren D, Turner WM, Faraone SV, Tsuang MT. Sex differences in olfactory identification and Wisconsin Card Sorting performance in schizophrenia: relationship to attention and verbal ability. Biol Psychiatry. 1997 Jul 15; 42(2):104-15. PMID: 9209727.
    View in: PubMed
  147. Lopate G, Parks BJ, Goldstein JM, Yee WC, Friesenhahn GM, Pestronk A. Polyneuropathies associated with high titre antisulphatide antibodies: characteristics of patients with and without serum monoclonal proteins. J Neurol Neurosurg Psychiatry. 1997 Jun; 62(6):581-5. PMID: 9219742; PMCID: PMC1074140.
  148. Goldstein JM. Managed care: it isn't for everyone but who is it for? J Calif Dent Assoc. 1997 Mar; 25(3):192-4. PMID: 9452659.
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  149. Kremen WS, Goldstein JM, Seidman LJ, Toomey R, Lyons MJ, Tsuang MT, Faraone SV. Sex differences in neuropsychological function in non-psychotic relatives of schizophrenic probands. Psychiatry Res. 1997 Feb 07; 66(2-3):131-44. PMID: 9075277.
    View in: PubMed
  150. Woods BT, Yurgelun-Todd D, Goldstein JM, Seidman LJ, Tsuang MT. MRI brain abnormalities in chronic schizophrenia: one process or more? Biol Psychiatry. 1996 Oct 01; 40(7):585-96. PMID: 8886291.
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  151. Goldstein JM. Sex and brain abnormalities in schizophrenia: fact or fiction? Harv Rev Psychiatry. 1996 Jul-Aug; 4(2):110-5. PMID: 9384983.
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  152. Hirsch SR, Link CG, Goldstein JM, Arvanitis LA. ICI 204,636: a new atypical antipsychotic drug. Br J Psychiatry Suppl. 1996 May; (29):45-56. PMID: 8733823.
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  153. Santangelo SL, Pauls DL, Lavori PW, Goldstein JM, Faraone SV, Tsuang MT. Assessing risk for the Tourette spectrum of disorders among first-degree relatives of probands with Tourette syndrome. Am J Med Genet. 1996 Feb 16; 67(1):107-16. PMID: 8678107.
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  154. Goldstein JM, Faraone SV, Chen WJ, Tsuang MT. Genetic heterogeneity may in part explain sex differences in the familial risk for schizophrenia. Biol Psychiatry. 1995 Dec 15; 38(12):808-13. PMID: 8750039.
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  155. Goldstein JM. Pharmacotherapy of schizophrenia. Lancet. 1995 Aug 12; 346(8972):450. PMID: 7623602.
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  156. Pestronk A, Choksi R, Bieser K, Goldstein JM, Adler CH, Caselli RJ, George EB. Treatable gait disorder and polyneuropathy associated with high titer serum IgM binding to antigens that copurify with myelin-associated glycoprotein. Muscle Nerve. 1994 Nov; 17(11):1293-300. PMID: 7523945.
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  157. Goldstein JM, Seidman LJ, Santangelo S, Knapp PH, Tsuang MT. Are schizophrenic men at higher risk for developmental deficits than schizophrenic women? Implications for adult neuropsychological functions. J Psychiatr Res. 1994 Nov-Dec; 28(6):483-98. PMID: 7699608.
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  158. Santangelo SL, Pauls DL, Goldstein JM, Faraone SV, Tsuang MT, Leckman JF. Tourette's syndrome: what are the influences of gender and comorbid obsessive-compulsive disorder? J Am Acad Child Adolesc Psychiatry. 1994 Jul-Aug; 33(6):795-804. PMID: 8083136.
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  159. Kremen WS, Seidman LJ, Goldstein JM, Faraone SV, Tsuang MT. Systematized delusions and neuropsychological function in paranoid and nonparanoid schizophrenia. Schizophr Res. 1994 Jun; 12(3):223-36. PMID: 8054314.
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  160. Pestronk A, Li F, Bieser K, Choksi R, Whitton A, Kornberg AJ, Goldstein JM, Yee WC. Anti-MAG antibodies: major effects of antigen purity and antibody cross-reactivity on ELISA results and clinical correlation. Neurology. 1994 Jun; 44(6):1131-7. PMID: 7516055.
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  161. Faraone SV, Chen WJ, Goldstein JM, Tsuang MT. Gender differences in age at onset of schizophrenia. Br J Psychiatry. 1994 May; 164(5):625-9. PMID: 7921712.
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  162. Seidman LJ, Yurgelun-Todd D, Kremen WS, Woods BT, Goldstein JM, Faraone SV, Tsuang MT. Relationship of prefrontal and temporal lobe MRI measures to neuropsychological performance in chronic schizophrenia. Biol Psychiatry. 1994 Feb 15; 35(4):235-46. PMID: 8186328.
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  163. Goldstein JM, Faraone SV, Chen WJ, Tsuang MT. The role of gender in understanding the familial transmission of schizoaffective disorder. Br J Psychiatry. 1993 Dec; 163:763-8. PMID: 8306118.
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  164. Goldstein JM, Santangelo SL, Simpson J, Tsuang MT. Gender and mortality in schizophrenia: do women act like men? Psychol Med. 1993 Nov; 23(4):941-8. PMID: 8134517.
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  165. Goldstein JM, Litwin LC, Sutton EB, Malick JB. Seroquel: electrophysiological profile of a potential atypical antipsychotic. Psychopharmacology (Berl). 1993; 112(2-3):293-8. PMID: 7871033.
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  166. Goldstein JM, Faraone SV, Chen WJ, Tsuang MT. Gender and the familial risk for schizophrenia. Disentangling confounding factors. Schizophr Res. 1992 Jul; 7(2):135-40. PMID: 1515374.
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  167. Goldstein JM, Shaywitz BA, Sze G, Nallainathan S. Migraine associated with focal cerebral edema, cerebrospinal fluid pleocytosis, and progressive cerebellar ataxia: MRI documentation. Neurology. 1990 Aug; 40(8):1284-7. PMID: 2381540.
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  168. Goldstein JM, Dziobek JF, Clark R, Bassuk EL. Supportive housing for the chronically mentally ill. Matching clients with community environments. J Nerv Ment Dis. 1990 Jul; 178(7):415-22. PMID: 2366055.
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  169. Goldstein JM, Faraone SV, Chen WJ, Tolomiczencko GS, Tsuang MT. Sex differences in the familial transmission of schizophrenia. Br J Psychiatry. 1990 Jun; 156:819-26. PMID: 2207512.
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  170. Goldstein JM, Santangelo SL, Simpson JC, Tsuang MT. The role of gender in identifying subtypes of schizophrenia: a latent class analytic approach. Schizophr Bull. 1990; 16(2):263-75. PMID: 2374884.
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  171. Angermeyer MC, Goldstein JM, Kuehn L. Gender differences in schizophrenia: rehospitalization and community survival. Psychol Med. 1989 May; 19(2):365-82. PMID: 2762441.
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  172. Goldstein JM, Kreisman D. Gender, family environment and schizophrenia. Psychol Med. 1988 Nov; 18(4):861-72. PMID: 3270831.
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  173. Goldstein JM. Gender differences in the course of schizophrenia. Am J Psychiatry. 1988 Jun; 145(6):684-9. PMID: 3369553.
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  174. Goldstein JM, Cohen P, Lewis SA, Struening EL. Community treatment environments. Patient vs. staff evaluations. J Nerv Ment Dis. 1988 Apr; 176(4):227-33. PMID: 3351501.
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  175. Goldstein JM, Link BG. Gender and the expression of schizophrenia. J Psychiatr Res. 1988; 22(2):141-55. PMID: 3404482.
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  176. Magaña AB, Goldstein JM, Karno M, Miklowitz DJ, Jenkins J, Falloon IR. A brief method for assessing expressed emotion in relatives of psychiatric patients. Psychiatry Res. 1986 Mar; 17(3):203-12. PMID: 3704028.
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  177. Caton CL, Koh SP, Fleiss JL, Barrow S, Goldstein JM. Rehospitalization in chronic schizophrenia. J Nerv Ment Dis. 1985 Mar; 173(3):139-48. PMID: 2983014.
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  178. Goldstein JM, Caton CL. The effects of the community environment on chronic psychiatric patients. Psychol Med. 1983 Feb; 13(1):193-9. PMID: 6302724.
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  179. Goldstein JM, Siegel J. Suppression of attack behavior in cats by stimulation of ventral tegmental area and nucleus accumbens. Brain Res. 1980 Feb 03; 183(1):181-92. PMID: 7188874.
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  180. Malick JB, Billingsley ML, Kubena RK, Goldstein JM. Evaluation of naloxone in laboratory tests predictive of clinical antipsychotic activity. Commun Psychopharmacol. 1977; 1(5):475-88. PMID: 23920.
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  181. Factor-Litvak P, Strakal N, Cherkerzian S, Richards M, Liu X, Sher A, Neils G, Buka S, Susser E, Goldstein JM. Associations between fetal inflammation and cognitive functions in middle aged adults.
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