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Zhigang He, Ph.D., B.M.

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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01EY030204 (HE, ZHIGANG) May 1, 2019 - Apr 30, 2024
    NIH/NEI
    CRSIPR screening for novel regulators of retinal ganglion cell survival and axonal regeneration
    Role: Principal Investigator
  2. R01NS110850 (HE, ZHIGANG) Mar 15, 2019 - Jan 31, 2024
    NIH/NINDS
    KCC2 and spinal cord injury
    Role: Principal Investigator
  3. R01NS109947 (WANG, FAN) Sep 30, 2018 - Jun 30, 2023
    NIH/NINDS
    Cortical Signature and Modulation of Pain
    Role: Co-Principal Investigator
  4. R01NS096294 (HE, ZHIGANG) Sep 1, 2016 - Jun 30, 2021
    NIH/NINDS
    Promoting axon regeneration and functional recovery after SCI
    Role: Principal Investigator
  5. R01EY026939 (HE, ZHIGANG) Aug 1, 2016 - Jul 31, 2021
    NIH/NEI
    Reprogramming Strategies of Promoting Optic Nerve Regeneration and Vision Restoration
    Role: Principal Investigator
This researcher has shared information about their research resources in the eagle-i Network. To update or add resource records, contact eagle-i@hms.harvard.edu.
Boston Children's Hospital Viral Core - Core services (3) and Instruments (7)

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Zhang Y, Williams PR, Jacobi A, Wang C, Goel A, Hirano AA, Brecha NC, Kerschensteiner D, He Z. Elevating Growth Factor Responsiveness and Axon Regeneration by Modulating Presynaptic Inputs. Neuron. 2019 Jul 03; 103(1):39-51.e5. PMID: 31122676.
    Citations:    
  2. Liu Y, Latremoliere A, Li X, Zhang Z, Chen M, Wang X, Fang C, Zhu J, Alexandre C, Gao Z, Chen B, Ding X, Zhou JY, Zhang Y, Chen C, Wang KH, Woolf CJ, He Z. Touch and tactile neuropathic pain sensitivity are set by corticospinal projections. Nature. 2018 09; 561(7724):547-550. PMID: 30209395.
    Citations:    Fields:    
  3. Chen B, Li Y, Yu B, Zhang Z, Brommer B, Williams PR, Liu Y, Hegarty SV, Zhou S, Zhu J, Guo H, Lu Y, Zhang Y, Gu X, He Z. Reactivation of Dormant Relay Pathways in Injured Spinal Cord by KCC2 Manipulations. Cell. 2018 07 26; 174(3):521-535.e13. PMID: 30033363.
    Citations: 1     Fields:    
  4. Wang X, Liu Y, Li X, Zhang Z, Yang H, Zhang Y, Williams PR, Alwahab NSA, Kapur K, Yu B, Zhang Y, Chen M, Ding H, Gerfen CR, Wang KH, He Z. Deconstruction of Corticospinal Circuits for Goal-Directed Motor Skills. Cell. 2017 Oct 05; 171(2):440-455.e14. PMID: 28942925.
    Citations: 6     Fields:    Translation:Animals
  5. Cartoni R, Pekkurnaz G, Wang C, Schwarz TL, He Z. A high mitochondrial transport rate characterizes CNS neurons with high axonal regeneration capacity. PLoS One. 2017; 12(9):e0184672. PMID: 28926622.
    Citations: 1     Fields:    Translation:AnimalsCells
  6. Liu Y, Wang X, Li W, Zhang Q, Li Y, Zhang Z, Zhu J, Chen B, Williams PR, Zhang Y, Yu B, Gu X, He Z. A Sensitized IGF1 Treatment Restores Corticospinal Axon-Dependent Functions. Neuron. 2017 Aug 16; 95(4):817-833.e4. PMID: 28817801.
    Citations: 10     Fields:    Translation:AnimalsCells
  7. Norsworthy MW, Bei F, Kawaguchi R, Wang Q, Tran NM, Li Y, Brommer B, Zhang Y, Wang C, Sanes JR, Coppola G, He Z. Sox11 Expression Promotes Regeneration of Some Retinal Ganglion Cell Types but Kills Others. Neuron. 2017 Jun 21; 94(6):1112-1120.e4. PMID: 28641110.
    Citations: 12     Fields:    Translation:AnimalsCells
  8. Cartoni R, Norsworthy MW, Bei F, Wang C, Li S, Zhang Y, Gabel CV, Schwarz TL, He Z. The Mammalian-Specific Protein Armcx1 Regulates Mitochondrial Transport during Axon Regeneration. Neuron. 2016 Dec 21; 92(6):1294-1307. PMID: 28009275.
    Citations: 16     Fields:    Translation:AnimalsCells
  9. Williams PR, He Z. Building bridges to regenerate axons. Science. 2016 11 04; 354(6312):544-545. PMID: 27811250.
    Citations: 1     Fields:    Translation:Cells
  10. He Z, Jin Y. Intrinsic Control of Axon Regeneration. Neuron. 2016 05 04; 90(3):437-51. PMID: 27151637.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  11. Bei F, Lee HHC, Liu X, Gunner G, Jin H, Ma L, Wang C, Hou L, Hensch TK, Frank E, Sanes JR, Chen C, Fagiolini M, He Z. Restoration of Visual Function by Enhancing Conduction in Regenerated Axons. Cell. 2016 Jan 14; 164(1-2):219-232. PMID: 26771493.
    Citations: 33     Fields:    Translation:AnimalsCells
  12. Benowitz LI, He Z, Goldberg JL. Reaching the brain: Advances in optic nerve regeneration. Exp Neurol. 2017 Jan; 287(Pt 3):365-373. PMID: 26746987.
    Citations: 26     Fields:    Translation:HumansAnimals
  13. Jin D, Liu Y, Sun F, Wang X, Liu X, He Z. Restoration of skilled locomotion by sprouting corticospinal axons induced by co-deletion of PTEN and SOCS3. Nat Commun. 2015 Nov 24; 6:8074. PMID: 26598325.
    Citations: 25     Fields:    Translation:AnimalsCells
  14. Nawabi H, Belin S, Cartoni R, Williams PR, Wang C, Latremolière A, Wang X, Zhu J, Taub DG, Fu X, Yu B, Gu X, Woolf CJ, Liu JS, Gabel CV, Steen JA, He Z. Doublecortin-Like Kinases Promote Neuronal Survival and Induce Growth Cone Reformation via Distinct Mechanisms. Neuron. 2015 Nov 18; 88(4):704-19. PMID: 26526391.
    Citations: 11     Fields:    Translation:AnimalsCells
  15. Omura T, Omura K, Tedeschi A, Riva P, Painter MW, Rojas L, Martin J, Lisi V, Huebner EA, Latremoliere A, Yin Y, Barrett LB, Singh B, Lee S, Crisman T, Gao F, Li S, Kapur K, Geschwind DH, Kosik KS, Coppola G, He Z, Carmichael ST, Benowitz LI, Costigan M, Woolf CJ. Robust Axonal Regeneration Occurs in the Injured CAST/Ei Mouse CNS. Neuron. 2015 Jun 03; 86(5):1215-27. PMID: 26004914.
    Citations: 20     Fields:    Translation:AnimalsCells
  16. Belin S, Nawabi H, Wang C, Tang S, Latremoliere A, Warren P, Schorle H, Uncu C, Woolf CJ, He Z, Steen JA. Injury-induced decline of intrinsic regenerative ability revealed by quantitative proteomics. Neuron. 2015 May 20; 86(4):1000-1014. PMID: 25937169.
    Citations: 40     Fields:    Translation:AnimalsCells
  17. Duan X, Qiao M, Bei F, Kim IJ, He Z, Sanes JR. Subtype-specific regeneration of retinal ganglion cells following axotomy: effects of osteopontin and mTOR signaling. Neuron. 2015 Mar 18; 85(6):1244-56. PMID: 25754821.
    Citations: 62     Fields:    Translation:AnimalsCells
  18. Liu X, Williams PR, He Z. SOCS3: a common target for neuronal protection and axon regeneration after spinal cord injury. Exp Neurol. 2015 Jan; 263:364-7. PMID: 25446722.
    Citations: 4     Fields:    Translation:Animals
  19. Ni Y, Nawabi H, Liu X, Yang L, Miyamichi K, Tedeschi A, Xu B, Wall NR, Callaway EM, He Z. Characterization of long descending premotor propriospinal neurons in the spinal cord. J Neurosci. 2014 Jul 09; 34(28):9404-17. PMID: 25009272.
    Citations: 9     Fields:    Translation:AnimalsCells
  20. Lu Y, Belin S, He Z. Signaling regulations of neuronal regenerative ability. Curr Opin Neurobiol. 2014 Aug; 27:135-42. PMID: 24727245.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  21. Belin S, Norsworthy M, He Z. Independent control of aging and axon regeneration. Cell Metab. 2014 Mar 04; 19(3):354-6. PMID: 24606896.
    Citations:    Fields:    Translation:HumansAnimalsCells
  22. Zukor K, Belin S, Wang C, Keelan N, Wang X, He Z. Short hairpin RNA against PTEN enhances regenerative growth of corticospinal tract axons after spinal cord injury. J Neurosci. 2013 Sep 25; 33(39):15350-61. PMID: 24068802.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  23. Nawabi H, Zukor K, He Z. No simpler than mammals: axon and dendrite regeneration in Drosophila. Genes Dev. 2012 Jul 15; 26(14):1509-14. PMID: 22802524.
    Citations: 2     Fields:    Translation:AnimalsCells
  24. Hu Y, Park KK, Yang L, Wei X, Yang Q, Cho KS, Thielen P, Lee AH, Cartoni R, Glimcher LH, Chen DF, He Z. Differential effects of unfolded protein response pathways on axon injury-induced death of retinal ganglion cells. Neuron. 2012 Feb 09; 73(3):445-52. PMID: 22325198.
    Citations: 54     Fields:    Translation:AnimalsCells
  25. Sun F, Park KK, Belin S, Wang D, Lu T, Chen G, Zhang K, Yeung C, Feng G, Yankner BA, He Z. Sustained axon regeneration induced by co-deletion of PTEN and SOCS3. Nature. 2011 Nov 06; 480(7377):372-5. PMID: 22056987.
    Citations: 191     Fields:    Translation:AnimalsCells
  26. Zukor K, He Z. Regenerative medicine: drawing breath after spinal injury. Nature. 2011 Jul 13; 475(7355):177-8. PMID: 21753842.
    Citations:    Fields:    Translation:HumansAnimalsCells
  27. Liu K, Tedeschi A, Park KK, He Z. Neuronal intrinsic mechanisms of axon regeneration. Annu Rev Neurosci. 2011; 34:131-52. PMID: 21438684.
    Citations: 143     Fields:    Translation:HumansAnimalsCells
  28. Tedeschi A, He Z. Axon regeneration: electrical silencing is a condition for regrowth. Curr Biol. 2010 Sep 14; 20(17):R713-4. PMID: 20833314.
    Citations: 1     Fields:    Translation:AnimalsCells
  29. Liu K, Lu Y, Lee JK, Samara R, Willenberg R, Sears-Kraxberger I, Tedeschi A, Park KK, Jin D, Cai B, Xu B, Connolly L, Steward O, Zheng B, He Z. PTEN deletion enhances the regenerative ability of adult corticospinal neurons. Nat Neurosci. 2010 Sep; 13(9):1075-81. PMID: 20694004.
    Citations: 257     Fields:    Translation:AnimalsCells
  30. Sun F, He Z. Neuronal intrinsic barriers for axon regeneration in the adult CNS. Curr Opin Neurobiol. 2010 Aug; 20(4):510-8. PMID: 20418094.
    Citations: 59     Fields:    Translation:AnimalsCells
  31. Park KK, Liu K, Hu Y, Kanter JL, He Z. PTEN/mTOR and axon regeneration. Exp Neurol. 2010 May; 223(1):45-50. PMID: 20079353.
    Citations: 85     Fields:    Translation:HumansAnimalsCells
  32. He Z. Intrinsic control of axon regeneration. J Biomed Res. 2010 Jan; 24(1):2-5. PMID: 23554605.
    Citations: 4     
  33. Smith PD, Sun F, Park KK, Cai B, Wang C, Kuwako K, Martinez-Carrasco I, Connolly L, He Z. SOCS3 deletion promotes optic nerve regeneration in vivo. Neuron. 2009 Dec 10; 64(5):617-23. PMID: 20005819.
    Citations: 142     Fields:    Translation:AnimalsCells
  34. Shen Y, Tenney AP, Busch SA, Horn KP, Cuascut FX, Liu K, He Z, Silver J, Flanagan JG. PTPsigma is a receptor for chondroitin sulfate proteoglycan, an inhibitor of neural regeneration. Science. 2009 Oct 23; 326(5952):592-6. PMID: 19833921.
    Citations: 196     Fields:    Translation:AnimalsCells
  35. Wang J, He Z. NAD and axon degeneration: from the Wlds gene to neurochemistry. Cell Adh Migr. 2009 Jan-Mar; 3(1):77-87. PMID: 19372760.
    Citations: 11     Fields:    Translation:AnimalsCells
  36. Park KK, Liu K, Hu Y, Smith PD, Wang C, Cai B, Xu B, Connolly L, Kramvis I, Sahin M, He Z. Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway. Science. 2008 Nov 07; 322(5903):963-6. PMID: 18988856.
    Citations: 433     Fields:    Translation:AnimalsCells
  37. Kaneko S, Wang J, Kaneko M, Yiu G, Hurrell JM, Chitnis T, Khoury SJ, He Z. Protecting axonal degeneration by increasing nicotinamide adenine dinucleotide levels in experimental autoimmune encephalomyelitis models. J Neurosci. 2006 Sep 20; 26(38):9794-804. PMID: 16988050.
    Citations: 50     Fields:    Translation:AnimalsCells
  38. Yiu G, He Z. Glial inhibition of CNS axon regeneration. Nat Rev Neurosci. 2006 Aug; 7(8):617-27. PMID: 16858390.
    Citations: 422     Fields:    Translation:HumansAnimalsCells
  39. Koprivica V, Cho KS, Park JB, Yiu G, Atwal J, Gore B, Kim JA, Lin E, Tessier-Lavigne M, Chen DF, He Z. EGFR activation mediates inhibition of axon regeneration by myelin and chondroitin sulfate proteoglycans. Science. 2005 Oct 07; 310(5745):106-10. PMID: 16210539.
    Citations: 88     Fields:    Translation:HumansAnimalsCells
  40. Wang J, Zhai Q, Chen Y, Lin E, Gu W, McBurney MW, He Z. A local mechanism mediates NAD-dependent protection of axon degeneration. J Cell Biol. 2005 Aug 01; 170(3):349-55. PMID: 16043516.
    Citations: 108     Fields:    Translation:AnimalsCells
  41. Park JB, Yiu G, Kaneko S, Wang J, Chang J, He XL, Garcia KC, He Z. A TNF receptor family member, TROY, is a coreceptor with Nogo receptor in mediating the inhibitory activity of myelin inhibitors. Neuron. 2005 Feb 03; 45(3):345-51. PMID: 15694321.
    Citations: 111     Fields:    Translation:AnimalsCells
  42. Fischer D, He Z, Benowitz LI. Counteracting the Nogo receptor enhances optic nerve regeneration if retinal ganglion cells are in an active growth state. J Neurosci. 2004 Feb 18; 24(7):1646-51. PMID: 14973241.
    Citations: 60     Fields:    Translation:AnimalsCells
  43. Sivasankaran R, Pei J, Wang KC, Zhang YP, Shields CB, Xu XM, He Z. PKC mediates inhibitory effects of myelin and chondroitin sulfate proteoglycans on axonal regeneration. Nat Neurosci. 2004 Mar; 7(3):261-8. PMID: 14770187.
    Citations: 89     Fields:    Translation:AnimalsCells
  44. He Z, Koprivica V. The Nogo signaling pathway for regeneration block. Annu Rev Neurosci. 2004; 27:341-68. PMID: 15217336.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  45. Yiu G, He Z. Signaling mechanisms of the myelin inhibitors of axon regeneration. Curr Opin Neurobiol. 2003 Oct; 13(5):545-51. PMID: 14630216.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  46. Zhai Q, Wang J, Kim A, Liu Q, Watts R, Hoopfer E, Mitchison T, Luo L, He Z. Involvement of the ubiquitin-proteasome system in the early stages of wallerian degeneration. Neuron. 2003 Jul 17; 39(2):217-25. PMID: 12873380.
    Citations: 83     Fields:    Translation:AnimalsCells
  47. Wang KC, Kim JA, Sivasankaran R, Segal R, He Z. P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp. Nature. 2002 Nov 07; 420(6911):74-8. PMID: 12422217.
    Citations: 190     Fields:    Translation:HumansAnimalsCells
  48. Wang KC, Koprivica V, Kim JA, Sivasankaran R, Guo Y, Neve RL, He Z. Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth. Nature. 2002 Jun 27; 417(6892):941-4. PMID: 12068310.
    Citations: 217     Fields:    Translation:HumansAnimalsCells
  49. He Z, Wang KC, Koprivica V, Ming G, Song HJ. Knowing how to navigate: mechanisms of semaphorin signaling in the nervous system. Sci STKE. 2002 Feb 12; 2002(119):re1. PMID: 11842242.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.