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profileZhigang He, Ph.D., B.M.

TitleProfessor of Neurology
InstitutionBoston Children's Hospital
DepartmentNeurology
AddressChildren's Hospital
6 Duxbury Rd
3 Blackfan Circle
Boston MA 02115
Phone617/355-2353
Fax617/730-0243
vCardDownload vCard (login for email)
Other Positions
TitleProfessor of Ophthalmology
InstitutionMassachusetts Eye and Ear Infirmary
DepartmentOphthalmology


Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01NS096294     (HE, ZHIGANG)Sep 1, 2016 - Jun 30, 2021
NIH/NINDS
Promoting axon regeneration and functional recovery after SCI
Role: Principal Investigator

R01EY026939     (HE, ZHIGANG)Aug 1, 2016 - Jul 31, 2021
NIH/NEI
Reprogramming Strategies of Promoting Optic Nerve Regeneration and Vision Restoration
Role: Principal Investigator

U01MH109107     (HE, ZHIGANG)Sep 23, 2015 - Jun 30, 2018
NIH/NIMH
Generating Multiple Circuit and Neuron Type Specific AAV Vectors With Cross-Species Applicability
Role: Principal Investigator

R01EY021526     (HE, ZHIGANG)May 1, 2011 - Feb 28, 2021
NIH/NEI
Rebuilding visual functional connections
Role: Principal Investigator

R01EY021342     (HE, ZHIGANG)Jan 1, 2011 - Dec 31, 2014
NIH/NEI
New Approach to promote optic nerve regeneration and vision restoration
Role: Principal Investigator
Collapse research resources
This researcher has shared information about their research resources
in the eagle-i Network. To update or add resource records, contact
eagle-i@hms.harvard.edu.
Boston Children's Hospital Viral Core - Core services (3) and Instruments (7)

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Wang X, Liu Y, Li X, Zhang Z, Yang H, Zhang Y, Williams PR, Alwahab NSA, Kapur K, Yu B, Zhang Y, Chen M, Ding H, Gerfen CR, Wang KH, He Z. Deconstruction of Corticospinal Circuits for Goal-Directed Motor Skills. Cell. 2017 Oct 05; 171(2):440-455.e14. PMID: 28942925.
    View in: PubMed
  2. Cartoni R, Pekkurnaz G, Wang C, Schwarz TL, He Z. A high mitochondrial transport rate characterizes CNS neurons with high axonal regeneration capacity. PLoS One. 2017; 12(9):e0184672. PMID: 28926622.
    View in: PubMed
  3. Liu Y, Wang X, Li W, Zhang Q, Li Y, Zhang Z, Zhu J, Chen B, Williams PR, Zhang Y, Yu B, Gu X, He Z. A Sensitized IGF1 Treatment Restores Corticospinal Axon-Dependent Functions. Neuron. 2017 Aug 16; 95(4):817-833.e4. PMID: 28817801.
    View in: PubMed
  4. Norsworthy MW, Bei F, Kawaguchi R, Wang Q, Tran NM, Li Y, Brommer B, Zhang Y, Wang C, Sanes JR, Coppola G, He Z. Sox11 Expression Promotes Regeneration of Some Retinal Ganglion Cell Types but Kills Others. Neuron. 2017 Jun 21; 94(6):1112-1120.e4. PMID: 28641110.
    View in: PubMed
  5. Cartoni R, Norsworthy MW, Bei F, Wang C, Li S, Zhang Y, Gabel CV, Schwarz TL, He Z. The Mammalian-Specific Protein Armcx1 Regulates Mitochondrial Transport during Axon Regeneration. Neuron. 2016 Dec 21; 92(6):1294-1307. PMID: 28009275.
    View in: PubMed
  6. Williams PR, He Z. Building bridges to regenerate axons. Science. 2016 11 04; 354(6312):544-545. PMID: 27811250.
    View in: PubMed
  7. He Z, Jin Y. Intrinsic Control of Axon Regeneration. Neuron. 2016 May 04; 90(3):437-51. PMID: 27151637.
    View in: PubMed
  8. Bei F, Lee HHC, Liu X, Gunner G, Jin H, Ma L, Wang C, Hou L, Hensch TK, Frank E, Sanes JR, Chen C, Fagiolini M, He Z. Restoration of Visual Function by Enhancing Conduction in Regenerated Axons. Cell. 2016 Jan 14; 164(1-2):219-232. PMID: 26771493; PMCID: PMC4863988 [Available on 01/14/17].
  9. Benowitz LI, He Z, Goldberg JL. Reaching the brain: Advances in optic nerve regeneration. Exp Neurol. 2017 Jan; 287(Pt 3):365-373. PMID: 26746987.
    View in: PubMed
  10. Jin D, Liu Y, Sun F, Wang X, Liu X, He Z. Restoration of skilled locomotion by sprouting corticospinal axons induced by co-deletion of PTEN and SOCS3. Nat Commun. 2015 Nov 24; 6:8074. PMID: 26598325; PMCID: PMC4662086 [Available on 05/24/16].
  11. Nawabi H, Belin S, Cartoni R, Williams PR, Wang C, Latremolière A, Wang X, Zhu J, Taub DG, Fu X, Yu B, Gu X, Woolf CJ, Liu JS, Gabel CV, Steen JA, He Z. Doublecortin-Like Kinases Promote Neuronal Survival and Induce Growth Cone Reformation via Distinct Mechanisms. Neuron. 2015 Nov 18; 88(4):704-19. PMID: 26526391.
    View in: PubMed
  12. Omura T, Omura K, Tedeschi A, Riva P, Painter MW, Rojas L, Martin J, Lisi V, Huebner EA, Latremoliere A, Yin Y, Barrett LB, Singh B, Lee S, Crisman T, Gao F, Li S, Kapur K, Geschwind DH, Kosik KS, Coppola G, He Z, Carmichael ST, Benowitz LI, Costigan M, Woolf CJ. Robust Axonal Regeneration Occurs in the Injured CAST/Ei Mouse CNS. Neuron. 2015 Jun 03; 86(5):1215-27. PMID: 26004914; PMCID: PMC4458182.
  13. Belin S, Nawabi H, Wang C, Tang S, Latremoliere A, Warren P, Schorle H, Uncu C, Woolf CJ, He Z, Steen JA. Injury-induced decline of intrinsic regenerative ability revealed by quantitative proteomics. Neuron. 2015 May 20; 86(4):1000-1014. PMID: 25937169; PMCID: PMC4551425.
  14. Duan X, Qiao M, Bei F, Kim IJ, He Z, Sanes JR. Subtype-specific regeneration of retinal ganglion cells following axotomy: effects of osteopontin and mTOR signaling. Neuron. 2015 Mar 18; 85(6):1244-56. PMID: 25754821; PMCID: PMC4391013.
  15. Liu X, Williams PR, He Z. SOCS3: a common target for neuronal protection and axon regeneration after spinal cord injury. Exp Neurol. 2015 Jan; 263:364-7. PMID: 25446722.
    View in: PubMed
  16. Ni Y, Nawabi H, Liu X, Yang L, Miyamichi K, Tedeschi A, Xu B, Wall NR, Callaway EM, He Z. Characterization of long descending premotor propriospinal neurons in the spinal cord. J Neurosci. 2014 Jul 09; 34(28):9404-17. PMID: 25009272; PMCID: PMC4468139.
  17. Lu Y, Belin S, He Z. Signaling regulations of neuronal regenerative ability. Curr Opin Neurobiol. 2014 Aug; 27:135-42. PMID: 24727245; PMCID: PMC4546824.
  18. Belin S, Norsworthy M, He Z. Independent control of aging and axon regeneration. Cell Metab. 2014 Mar 04; 19(3):354-6. PMID: 24606896; PMCID: PMC4049281.
  19. Zukor K, Belin S, Wang C, Keelan N, Wang X, He Z. Short hairpin RNA against PTEN enhances regenerative growth of corticospinal tract axons after spinal cord injury. J Neurosci. 2013 Sep 25; 33(39):15350-61. PMID: 24068802; PMCID: PMC3782617.
  20. Nawabi H, Zukor K, He Z. No simpler than mammals: axon and dendrite regeneration in Drosophila. Genes Dev. 2012 Jul 15; 26(14):1509-14. PMID: 22802524; PMCID: PMC3404378.
  21. Hu Y, Park KK, Yang L, Wei X, Yang Q, Cho KS, Thielen P, Lee AH, Cartoni R, Glimcher LH, Chen DF, He Z. Differential effects of unfolded protein response pathways on axon injury-induced death of retinal ganglion cells. Neuron. 2012 Feb 09; 73(3):445-52. PMID: 22325198; PMCID: PMC3278720.
  22. Sun F, Park KK, Belin S, Wang D, Lu T, Chen G, Zhang K, Yeung C, Feng G, Yankner BA, He Z. Sustained axon regeneration induced by co-deletion of PTEN and SOCS3. Nature. 2011 Nov 06; 480(7377):372-5. PMID: 22056987; PMCID: PMC3240702.
  23. Zukor K, He Z. Regenerative medicine: drawing breath after spinal injury. Nature. 2011 Jul 13; 475(7355):177-8. PMID: 21753842.
    View in: PubMed
  24. Liu K, Tedeschi A, Park KK, He Z. Neuronal intrinsic mechanisms of axon regeneration. Annu Rev Neurosci. 2011; 34:131-52. PMID: 21438684.
    View in: PubMed
  25. Tedeschi A, He Z. Axon regeneration: electrical silencing is a condition for regrowth. Curr Biol. 2010 Sep 14; 20(17):R713-4. PMID: 20833314.
    View in: PubMed
  26. Liu K, Lu Y, Lee JK, Samara R, Willenberg R, Sears-Kraxberger I, Tedeschi A, Park KK, Jin D, Cai B, Xu B, Connolly L, Steward O, Zheng B, He Z. PTEN deletion enhances the regenerative ability of adult corticospinal neurons. Nat Neurosci. 2010 Sep; 13(9):1075-81. PMID: 20694004; PMCID: PMC2928871.
  27. Sun F, He Z. Neuronal intrinsic barriers for axon regeneration in the adult CNS. Curr Opin Neurobiol. 2010 Aug; 20(4):510-8. PMID: 20418094; PMCID: PMC2911501.
  28. Park KK, Liu K, Hu Y, Kanter JL, He Z. PTEN/mTOR and axon regeneration. Exp Neurol. 2010 May; 223(1):45-50. PMID: 20079353.
    View in: PubMed
  29. He Z. Intrinsic control of axon regeneration. J Biomed Res. 2010 Jan; 24(1):2-5. PMID: 23554605; PMCID: PMC3596529.
  30. Smith PD, Sun F, Park KK, Cai B, Wang C, Kuwako K, Martinez-Carrasco I, Connolly L, He Z. SOCS3 deletion promotes optic nerve regeneration in vivo. Neuron. 2009 Dec 10; 64(5):617-23. PMID: 20005819; PMCID: PMC2796263.
  31. Shen Y, Tenney AP, Busch SA, Horn KP, Cuascut FX, Liu K, He Z, Silver J, Flanagan JG. PTPsigma is a receptor for chondroitin sulfate proteoglycan, an inhibitor of neural regeneration. Science. 2009 Oct 23; 326(5952):592-6. PMID: 19833921; PMCID: PMC2811318.
  32. Wang J, He Z. NAD and axon degeneration: from the Wlds gene to neurochemistry. Cell Adh Migr. 2009 Jan-Mar; 3(1):77-87. PMID: 19372760; PMCID: PMC2675153.
  33. Park KK, Liu K, Hu Y, Smith PD, Wang C, Cai B, Xu B, Connolly L, Kramvis I, Sahin M, He Z. Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway. Science. 2008 Nov 07; 322(5903):963-6. PMID: 18988856; PMCID: PMC2652400.
  34. Kaneko S, Wang J, Kaneko M, Yiu G, Hurrell JM, Chitnis T, Khoury SJ, He Z. Protecting axonal degeneration by increasing nicotinamide adenine dinucleotide levels in experimental autoimmune encephalomyelitis models. J Neurosci. 2006 Sep 20; 26(38):9794-804. PMID: 16988050.
    View in: PubMed
  35. Yiu G, He Z. Glial inhibition of CNS axon regeneration. Nat Rev Neurosci. 2006 Aug; 7(8):617-27. PMID: 16858390; PMCID: PMC2693386.
  36. Koprivica V, Cho KS, Park JB, Yiu G, Atwal J, Gore B, Kim JA, Lin E, Tessier-Lavigne M, Chen DF, He Z. EGFR activation mediates inhibition of axon regeneration by myelin and chondroitin sulfate proteoglycans. Science. 2005 Oct 07; 310(5745):106-10. PMID: 16210539.
    View in: PubMed
  37. Wang J, Zhai Q, Chen Y, Lin E, Gu W, McBurney MW, He Z. A local mechanism mediates NAD-dependent protection of axon degeneration. J Cell Biol. 2005 Aug 01; 170(3):349-55. PMID: 16043516; PMCID: PMC2171458.
  38. Park JB, Yiu G, Kaneko S, Wang J, Chang J, He XL, Garcia KC, He Z. A TNF receptor family member, TROY, is a coreceptor with Nogo receptor in mediating the inhibitory activity of myelin inhibitors. Neuron. 2005 Feb 03; 45(3):345-51. PMID: 15694321.
    View in: PubMed
  39. Fischer D, He Z, Benowitz LI. Counteracting the Nogo receptor enhances optic nerve regeneration if retinal ganglion cells are in an active growth state. J Neurosci. 2004 Feb 18; 24(7):1646-51. PMID: 14973241.
    View in: PubMed
  40. Sivasankaran R, Pei J, Wang KC, Zhang YP, Shields CB, Xu XM, He Z. PKC mediates inhibitory effects of myelin and chondroitin sulfate proteoglycans on axonal regeneration. Nat Neurosci. 2004 Mar; 7(3):261-8. PMID: 14770187.
    View in: PubMed
  41. He Z, Koprivica V. The Nogo signaling pathway for regeneration block. Annu Rev Neurosci. 2004; 27:341-68. PMID: 15217336.
    View in: PubMed
  42. Yiu G, He Z. Signaling mechanisms of the myelin inhibitors of axon regeneration. Curr Opin Neurobiol. 2003 Oct; 13(5):545-51. PMID: 14630216.
    View in: PubMed
  43. Zhai Q, Wang J, Kim A, Liu Q, Watts R, Hoopfer E, Mitchison T, Luo L, He Z. Involvement of the ubiquitin-proteasome system in the early stages of wallerian degeneration. Neuron. 2003 Jul 17; 39(2):217-25. PMID: 12873380.
    View in: PubMed
  44. Wang KC, Kim JA, Sivasankaran R, Segal R, He Z. P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp. Nature. 2002 Nov 07; 420(6911):74-8. PMID: 12422217.
    View in: PubMed
  45. Wang KC, Koprivica V, Kim JA, Sivasankaran R, Guo Y, Neve RL, He Z. Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth. Nature. 2002 Jun 27; 417(6892):941-4. PMID: 12068310.
    View in: PubMed
  46. He Z, Wang KC, Koprivica V, Ming G, Song HJ. Knowing how to navigate: mechanisms of semaphorin signaling in the nervous system. Sci STKE. 2002 Feb 12; 2002(119):re1. PMID: 11842242.
    View in: PubMed
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