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Zhigang He, Ph.D., B.M.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AT010779 (HE, ZHIGANG) Sep 15, 2019 - Aug 31, 2024
    NIH
    Mechanism and Optimization of CBD-mediated analgesic effects
    Role: Principal Investigator
  2. R01EY030204 (HE, ZHIGANG) May 1, 2019 - Apr 30, 2024
    NIH
    CRSIPR screening for novel regulators of retinal ganglion cell survival and axonal regeneration
    Role: Principal Investigator
  3. R01NS110850 (HE, ZHIGANG) Mar 15, 2019 - Feb 29, 2024
    NIH
    KCC2 and Spinal Cord Injury
    Role: Principal Investigator
  4. R01NS109947 (WANG, FAN) Sep 30, 2018 - Jun 30, 2023
    NIH
    Cortical Signature and Modulation of Pain
    Role: Co-Principal Investigator
  5. R01NS096294 (HE, ZHIGANG) Sep 1, 2016 - Jun 30, 2021
    NIH
    Promoting axon regeneration and functional recovery after SCI
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Winter CC, He Z, Jacobi A. Axon Regeneration: A Subcellular Extension in Multiple Dimensions. Cold Spring Harb Perspect Biol. 2022 03 01; 14(3). PMID: 34518340.
    Citations:    Fields:    
  2. Harbauer AB, Hees JT, Wanderoy S, Segura I, Gibbs W, Cheng Y, Ordonez M, Cai Z, Cartoni R, Ashrafi G, Wang C, Perocchi F, He Z, Schwarz TL. Neuronal mitochondria transport Pink1 mRNA via synaptojanin 2 to support local mitophagy. Neuron. 2022 Feb 19. PMID: 35216662.
    Citations:    Fields:    
  3. Suter TACS, Wang J, Meng H, He Z. Utilizing mouse optic nerve crush to examine CNS remyelination. STAR Protoc. 2021 09 17; 2(3):100796. PMID: 34786561.
    Citations:    Fields:    
  4. Brommer B, He M, Zhang Z, Yang Z, Page JC, Su J, Zhang Y, Zhu J, Gouy E, Tang J, Williams P, Dai W, Wang Q, Solinsky R, Chen B, He Z. Improving hindlimb locomotor function by Non-invasive AAV-mediated manipulations of propriospinal neurons in mice with complete spinal cord injury. Nat Commun. 2021 02 03; 12(1):781. PMID: 33536416.
    Citations: 2     Fields:    Translation:AnimalsCells
  5. Lu Y, Brommer B, Tian X, Krishnan A, Meer M, Wang C, Vera DL, Zeng Q, Yu D, Bonkowski MS, Yang JH, Zhou S, Hoffmann EM, Karg MM, Schultz MB, Kane AE, Davidsohn N, Korobkina E, Chwalek K, Rajman LA, Church GM, Hochedlinger K, Gladyshev VN, Horvath S, Levine ME, Gregory-Ksander MS, Ksander BR, He Z, Sinclair DA. Reprogramming to recover youthful epigenetic information and restore vision. Nature. 2020 12; 588(7836):124-129. PMID: 33268865.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  6. Wang J, He X, Meng H, Li Y, Dmitriev P, Tian F, Page JC, Lu QR, He Z. Robust Myelination of Regenerated Axons Induced by Combined Manipulations of GPR17 and Microglia. Neuron. 2020 12 09; 108(5):876-886.e4. PMID: 33108748.
    Citations: 17     Fields:    Translation:AnimalsCells
  7. Li Y, He X, Kawaguchi R, Zhang Y, Wang Q, Monavarfeshani A, Yang Z, Chen B, Shi Z, Meng H, Zhou S, Zhu J, Jacobi A, Swarup V, Popovich PG, Geschwind DH, He Z. Microglia-organized scar-free spinal cord repair in neonatal mice. Nature. 2020 11; 587(7835):613-618. PMID: 33029008.
    Citations: 35     Fields:    Translation:AnimalsCells
  8. Gan W, Dai X, Dai X, Xie J, Yin S, Zhu J, Wang C, Liu Y, Guo J, Wang M, Liu J, Hu J, Quinton RJ, Ganem NJ, Liu P, Asara JM, Pandolfi PP, Yang Y, He Z, Gao G, Wei W. LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control. Nat Cell Biol. 2020 02; 22(2):246-256. PMID: 32015438.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  9. Tran NM, Shekhar K, Whitney IE, Jacobi A, Benhar I, Hong G, Yan W, Adiconis X, Arnold ME, Lee JM, Levin JZ, Lin D, Wang C, Lieber CM, Regev A, He Z, Sanes JR. Single-Cell Profiles of Retinal Ganglion Cells Differing in Resilience to Injury Reveal Neuroprotective Genes. Neuron. 2019 12 18; 104(6):1039-1055.e12. PMID: 31784286.
    Citations: 110     Fields:    Translation:AnimalsCells
  10. Zhang Y, Williams PR, Jacobi A, Wang C, Goel A, Hirano AA, Brecha NC, Kerschensteiner D, He Z. Elevating Growth Factor Responsiveness and Axon Regeneration by Modulating Presynaptic Inputs. Neuron. 2019 07 03; 103(1):39-51.e5. PMID: 31122676.
    Citations: 25     Fields:    Translation:AnimalsCells
  11. Liu Y, Latremoliere A, Li X, Zhang Z, Chen M, Wang X, Fang C, Zhu J, Alexandre C, Gao Z, Chen B, Ding X, Zhou JY, Zhang Y, Chen C, Wang KH, Woolf CJ, He Z. Touch and tactile neuropathic pain sensitivity are set by corticospinal projections. Nature. 2018 09; 561(7724):547-550. PMID: 30209395.
    Citations: 54     Fields:    Translation:AnimalsCells
  12. Chen B, Li Y, Yu B, Zhang Z, Brommer B, Williams PR, Liu Y, Hegarty SV, Zhou S, Zhu J, Guo H, Lu Y, Zhang Y, Gu X, He Z. Reactivation of Dormant Relay Pathways in Injured Spinal Cord by KCC2 Manipulations. Cell. 2018 07 26; 174(3):521-535.e13. PMID: 30033363.
    Citations: 43     Fields:    Translation:AnimalsCells
  13. Wang X, Liu Y, Li X, Zhang Z, Yang H, Zhang Y, Williams PR, Alwahab NSA, Kapur K, Yu B, Zhang Y, Chen M, Ding H, Gerfen CR, Wang KH, He Z. Deconstruction of Corticospinal Circuits for Goal-Directed Motor Skills. Cell. 2017 Oct 05; 171(2):440-455.e14. PMID: 28942925.
    Citations: 45     Fields:    Translation:Animals
  14. Cartoni R, Pekkurnaz G, Wang C, Schwarz TL, He Z. A high mitochondrial transport rate characterizes CNS neurons with high axonal regeneration capacity. PLoS One. 2017; 12(9):e0184672. PMID: 28926622.
    Citations: 11     Fields:    Translation:AnimalsCells
  15. Liu Y, Wang X, Li W, Zhang Q, Li Y, Zhang Z, Zhu J, Chen B, Williams PR, Zhang Y, Yu B, Gu X, He Z. A Sensitized IGF1 Treatment Restores Corticospinal Axon-Dependent Functions. Neuron. 2017 Aug 16; 95(4):817-833.e4. PMID: 28817801.
    Citations: 51     Fields:    Translation:AnimalsCells
  16. Norsworthy MW, Bei F, Kawaguchi R, Wang Q, Tran NM, Li Y, Brommer B, Zhang Y, Wang C, Sanes JR, Coppola G, He Z. Sox11 Expression Promotes Regeneration of Some Retinal Ganglion Cell Types but Kills Others. Neuron. 2017 Jun 21; 94(6):1112-1120.e4. PMID: 28641110.
    Citations: 59     Fields:    Translation:AnimalsCells
  17. Cartoni R, Norsworthy MW, Bei F, Wang C, Li S, Zhang Y, Gabel CV, Schwarz TL, He Z. The Mammalian-Specific Protein Armcx1 Regulates Mitochondrial Transport during Axon Regeneration. Neuron. 2016 Dec 21; 92(6):1294-1307. PMID: 28009275.
    Citations: 59     Fields:    Translation:AnimalsCells
  18. Williams PR, He Z. Building bridges to regenerate axons. Science. 2016 11 04; 354(6312):544-545. PMID: 27811250.
    Citations: 1     Fields:    Translation:Cells
  19. He Z, Jin Y. Intrinsic Control of Axon Regeneration. Neuron. 2016 05 04; 90(3):437-51. PMID: 27151637.
    Citations: 180     Fields:    Translation:HumansAnimalsCells
  20. Bei F, Lee HHC, Liu X, Gunner G, Jin H, Ma L, Wang C, Hou L, Hensch TK, Frank E, Sanes JR, Chen C, Fagiolini M, He Z. Restoration of Visual Function by Enhancing Conduction in Regenerated Axons. Cell. 2016 Jan 14; 164(1-2):219-232. PMID: 26771493.
    Citations: 88     Fields:    Translation:AnimalsCells
  21. Benowitz LI, He Z, Goldberg JL. Reaching the brain: Advances in optic nerve regeneration. Exp Neurol. 2017 Jan; 287(Pt 3):365-373. PMID: 26746987.
    Citations: 80     Fields:    Translation:HumansAnimals
  22. Jin D, Liu Y, Sun F, Wang X, Liu X, He Z. Restoration of skilled locomotion by sprouting corticospinal axons induced by co-deletion of PTEN and SOCS3. Nat Commun. 2015 Nov 24; 6:8074. PMID: 26598325.
    Citations: 68     Fields:    Translation:AnimalsCells
  23. Nawabi H, Belin S, Cartoni R, Williams PR, Wang C, Latremolière A, Wang X, Zhu J, Taub DG, Fu X, Yu B, Gu X, Woolf CJ, Liu JS, Gabel CV, Steen JA, He Z. Doublecortin-Like Kinases Promote Neuronal Survival and Induce Growth Cone Reformation via Distinct Mechanisms. Neuron. 2015 Nov 18; 88(4):704-19. PMID: 26526391.
    Citations: 32     Fields:    Translation:AnimalsCells
  24. Omura T, Omura K, Tedeschi A, Riva P, Painter MW, Rojas L, Martin J, Lisi V, Huebner EA, Latremoliere A, Yin Y, Barrett LB, Singh B, Lee S, Crisman T, Gao F, Li S, Kapur K, Geschwind DH, Kosik KS, Coppola G, He Z, Carmichael ST, Benowitz LI, Costigan M, Woolf CJ. Robust Axonal Regeneration Occurs in the Injured CAST/Ei Mouse CNS. Neuron. 2015 Jun 03; 86(5):1215-27. PMID: 26004914.
    Citations: 40     Fields:    Translation:AnimalsCells
  25. Belin S, Nawabi H, Wang C, Tang S, Latremoliere A, Warren P, Schorle H, Uncu C, Woolf CJ, He Z, Steen JA. Injury-induced decline of intrinsic regenerative ability revealed by quantitative proteomics. Neuron. 2015 May 20; 86(4):1000-1014. PMID: 25937169.
    Citations: 91     Fields:    Translation:AnimalsCells
  26. Duan X, Qiao M, Bei F, Kim IJ, He Z, Sanes JR. Subtype-specific regeneration of retinal ganglion cells following axotomy: effects of osteopontin and mTOR signaling. Neuron. 2015 Mar 18; 85(6):1244-56. PMID: 25754821.
    Citations: 182     Fields:    Translation:AnimalsCells
  27. Liu X, Williams PR, He Z. SOCS3: a common target for neuronal protection and axon regeneration after spinal cord injury. Exp Neurol. 2015 Jan; 263:364-7. PMID: 25446722.
    Citations: 13     Fields:    Translation:Animals
  28. Ni Y, Nawabi H, Liu X, Yang L, Miyamichi K, Tedeschi A, Xu B, Wall NR, Callaway EM, He Z. Characterization of long descending premotor propriospinal neurons in the spinal cord. J Neurosci. 2014 Jul 09; 34(28):9404-17. PMID: 25009272.
    Citations: 31     Fields:    Translation:AnimalsCells
  29. Lu Y, Belin S, He Z. Signaling regulations of neuronal regenerative ability. Curr Opin Neurobiol. 2014 Aug; 27:135-42. PMID: 24727245.
    Citations: 60     Fields:    Translation:HumansAnimalsCells
  30. Belin S, Norsworthy M, He Z. Independent control of aging and axon regeneration. Cell Metab. 2014 Mar 04; 19(3):354-6. PMID: 24606896.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  31. Zukor K, Belin S, Wang C, Keelan N, Wang X, He Z. Short hairpin RNA against PTEN enhances regenerative growth of corticospinal tract axons after spinal cord injury. J Neurosci. 2013 Sep 25; 33(39):15350-61. PMID: 24068802.
    Citations: 117     Fields:    Translation:HumansAnimalsCells
  32. Nawabi H, Zukor K, He Z. No simpler than mammals: axon and dendrite regeneration in Drosophila. Genes Dev. 2012 Jul 15; 26(14):1509-14. PMID: 22802524.
    Citations: 8     Fields:    Translation:AnimalsCells
  33. Hu Y, Park KK, Yang L, Wei X, Yang Q, Cho KS, Thielen P, Lee AH, Cartoni R, Glimcher LH, Chen DF, He Z. Differential effects of unfolded protein response pathways on axon injury-induced death of retinal ganglion cells. Neuron. 2012 Feb 09; 73(3):445-52. PMID: 22325198.
    Citations: 95     Fields:    Translation:AnimalsCells
  34. Sun F, Park KK, Belin S, Wang D, Lu T, Chen G, Zhang K, Yeung C, Feng G, Yankner BA, He Z. Sustained axon regeneration induced by co-deletion of PTEN and SOCS3. Nature. 2011 Nov 06; 480(7377):372-5. PMID: 22056987.
    Citations: 318     Fields:    Translation:AnimalsCells
  35. Zukor K, He Z. Regenerative medicine: drawing breath after spinal injury. Nature. 2011 Jul 13; 475(7355):177-8. PMID: 21753842.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  36. Liu K, Tedeschi A, Park KK, He Z. Neuronal intrinsic mechanisms of axon regeneration. Annu Rev Neurosci. 2011; 34:131-52. PMID: 21438684.
    Citations: 202     Fields:    Translation:HumansAnimalsCells
  37. Tedeschi A, He Z. Axon regeneration: electrical silencing is a condition for regrowth. Curr Biol. 2010 Sep 14; 20(17):R713-4. PMID: 20833314.
    Citations: 3     Fields:    Translation:AnimalsCells
  38. Liu K, Lu Y, Lee JK, Samara R, Willenberg R, Sears-Kraxberger I, Tedeschi A, Park KK, Jin D, Cai B, Xu B, Connolly L, Steward O, Zheng B, He Z. PTEN deletion enhances the regenerative ability of adult corticospinal neurons. Nat Neurosci. 2010 Sep; 13(9):1075-81. PMID: 20694004.
    Citations: 414     Fields:    Translation:AnimalsCells
  39. Sun F, He Z. Neuronal intrinsic barriers for axon regeneration in the adult CNS. Curr Opin Neurobiol. 2010 Aug; 20(4):510-8. PMID: 20418094.
    Citations: 89     Fields:    Translation:AnimalsCells
  40. Park KK, Liu K, Hu Y, Kanter JL, He Z. PTEN/mTOR and axon regeneration. Exp Neurol. 2010 May; 223(1):45-50. PMID: 20079353.
    Citations: 132     Fields:    Translation:HumansAnimalsCells
  41. He Z. Intrinsic control of axon regeneration. J Biomed Res. 2010 Jan; 24(1):2-5. PMID: 23554605.
    Citations: 8     
  42. Smith PD, Sun F, Park KK, Cai B, Wang C, Kuwako K, Martinez-Carrasco I, Connolly L, He Z. SOCS3 deletion promotes optic nerve regeneration in vivo. Neuron. 2009 Dec 10; 64(5):617-23. PMID: 20005819.
    Citations: 212     Fields:    Translation:AnimalsCells
  43. Shen Y, Tenney AP, Busch SA, Horn KP, Cuascut FX, Liu K, He Z, Silver J, Flanagan JG. PTPsigma is a receptor for chondroitin sulfate proteoglycan, an inhibitor of neural regeneration. Science. 2009 Oct 23; 326(5952):592-6. PMID: 19833921.
    Citations: 283     Fields:    Translation:AnimalsCells
  44. Wang J, He Z. NAD and axon degeneration: from the Wlds gene to neurochemistry. Cell Adh Migr. 2009 Jan-Mar; 3(1):77-87. PMID: 19372760.
    Citations: 17     Fields:    Translation:AnimalsCells
  45. Park KK, Liu K, Hu Y, Smith PD, Wang C, Cai B, Xu B, Connolly L, Kramvis I, Sahin M, He Z. Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway. Science. 2008 Nov 07; 322(5903):963-6. PMID: 18988856.
    Citations: 699     Fields:    Translation:AnimalsCells
  46. Kaneko S, Wang J, Kaneko M, Yiu G, Hurrell JM, Chitnis T, Khoury SJ, He Z. Protecting axonal degeneration by increasing nicotinamide adenine dinucleotide levels in experimental autoimmune encephalomyelitis models. J Neurosci. 2006 Sep 20; 26(38):9794-804. PMID: 16988050.
    Citations: 74     Fields:    Translation:AnimalsCells
  47. Yiu G, He Z. Glial inhibition of CNS axon regeneration. Nat Rev Neurosci. 2006 Aug; 7(8):617-27. PMID: 16858390.
    Citations: 611     Fields:    Translation:HumansAnimalsCells
  48. Koprivica V, Cho KS, Park JB, Yiu G, Atwal J, Gore B, Kim JA, Lin E, Tessier-Lavigne M, Chen DF, He Z. EGFR activation mediates inhibition of axon regeneration by myelin and chondroitin sulfate proteoglycans. Science. 2005 Oct 07; 310(5745):106-10. PMID: 16210539.
    Citations: 127     Fields:    Translation:HumansAnimalsCells
  49. Wang J, Zhai Q, Chen Y, Lin E, Gu W, McBurney MW, He Z. A local mechanism mediates NAD-dependent protection of axon degeneration. J Cell Biol. 2005 Aug 01; 170(3):349-55. PMID: 16043516.
    Citations: 169     Fields:    Translation:AnimalsCells
  50. Park JB, Yiu G, Kaneko S, Wang J, Chang J, He XL, Garcia KC, He Z. A TNF receptor family member, TROY, is a coreceptor with Nogo receptor in mediating the inhibitory activity of myelin inhibitors. Neuron. 2005 Feb 03; 45(3):345-51. PMID: 15694321.
    Citations: 141     Fields:    Translation:AnimalsCells
  51. Fischer D, He Z, Benowitz LI. Counteracting the Nogo receptor enhances optic nerve regeneration if retinal ganglion cells are in an active growth state. J Neurosci. 2004 Feb 18; 24(7):1646-51. PMID: 14973241.
    Citations: 88     Fields:    Translation:AnimalsCells
  52. Sivasankaran R, Pei J, Wang KC, Zhang YP, Shields CB, Xu XM, He Z. PKC mediates inhibitory effects of myelin and chondroitin sulfate proteoglycans on axonal regeneration. Nat Neurosci. 2004 Mar; 7(3):261-8. PMID: 14770187.
    Citations: 118     Fields:    Translation:AnimalsCells
  53. He Z, Koprivica V. The Nogo signaling pathway for regeneration block. Annu Rev Neurosci. 2004; 27:341-68. PMID: 15217336.
    Citations: 77     Fields:    Translation:HumansAnimalsCells
  54. Yiu G, He Z. Signaling mechanisms of the myelin inhibitors of axon regeneration. Curr Opin Neurobiol. 2003 Oct; 13(5):545-51. PMID: 14630216.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  55. Zhai Q, Wang J, Kim A, Liu Q, Watts R, Hoopfer E, Mitchison T, Luo L, He Z. Involvement of the ubiquitin-proteasome system in the early stages of wallerian degeneration. Neuron. 2003 Jul 17; 39(2):217-25. PMID: 12873380.
    Citations: 123     Fields:    Translation:AnimalsCells
  56. Wang KC, Kim JA, Sivasankaran R, Segal R, He Z. P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp. Nature. 2002 Nov 07; 420(6911):74-8. PMID: 12422217.
    Citations: 258     Fields:    Translation:HumansAnimalsCells
  57. Wang KC, Koprivica V, Kim JA, Sivasankaran R, Guo Y, Neve RL, He Z. Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth. Nature. 2002 Jun 27; 417(6892):941-4. PMID: 12068310.
    Citations: 294     Fields:    Translation:HumansAnimalsCells
  58. He Z, Wang KC, Koprivica V, Ming G, Song HJ. Knowing how to navigate: mechanisms of semaphorin signaling in the nervous system. Sci STKE. 2002 Feb 12; 2002(119):re1. PMID: 11842242.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.