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Radhika Basheer, Ph.D.

Other Positions

Madurai Kamaraj University, Tamil Nadu, IndiaMSc05/1979Molecular Biology
Madurai Kamaraj University, Tamil Nadu, IndiaPh.D.01/1988Molecular Biology

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. IS1BX004396 (BASHEER, RADHIKA) Jan 1, 2018 - Sep 30, 2018
    ShEEP Request for Q-Exactive HF-X Mass Spectrometer with EASY-nLC
    Role: Principal Investigator
  2. R21NS079866 (BASHEER, RADHIKA) Jul 1, 2012 - Jun 30, 2014
    Optogenetic dissection of basal forebrain neurons involved in sleep homeostasis
    Role: Principal Investigator
  3. I01BX001404 (BASHEER, RADHIKA) Oct 1, 2011 - Sep 30, 2015
    Purinergic Mechanisms in Homeostatic Sleep Control
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Uygun DS, Basheer R. Circuits and components of delta wave regulation. Brain Res Bull. 2022 10 01; 188:223-232. PMID: 35738502; PMCID: PMC9680038.
    Citations:    Fields:    
  2. Uygun DS, Yang C, Tilli ER, Katsuki F, Hodges EL, McKenna JT, McNally JM, Brown RE, Basheer R. Knockdown of GABAA alpha3 subunits on thalamic reticular neurons enhances deep sleep in mice. Nat Commun. 2022 04 26; 13(1):2246. PMID: 35473906; PMCID: PMC9042958.
    Citations: 1     Fields:    Translation:AnimalsCells
  3. McKenna JT, Yang C, Bellio T, Anderson-Chernishof MB, Gamble MC, Hulverson A, McCoy JG, Winston S, Hodges E, Katsuki F, McNally JM, Basheer R, Brown RE. Characterization of basal forebrain glutamate neurons suggests a role in control of arousal and avoidance behavior. Brain Struct Funct. 2021 Jul; 226(6):1755-1778. PMID: 33997911; PMCID: PMC8340131.
    Citations:    Fields:    Translation:AnimalsCells
  4. McKenna JT, Thankachan S, Uygun DS, Shukla C, McNally JM, Schiffino FL, Cordeira J, Katsuki F, Zant JC, Gamble MC, Deisseroth K, McCarley RW, Brown RE, Strecker RE, Basheer R. Basal Forebrain Parvalbumin Neurons Mediate Arousals from Sleep Induced by Hypercarbia or Auditory Stimuli. Curr Biol. 2020 06 22; 30(12):2379-2385.e4. PMID: 32413301.
    Citations: 7     Fields:    Translation:AnimalsCells
  5. Aguilar DD, Strecker RE, Basheer R, McNally JM. Alterations in sleep, sleep spindle, and EEG power in mGluR5 knockout mice. J Neurophysiol. 2020 01 01; 123(1):22-33. PMID: 31747354.
    Citations: 10     Fields:    Translation:Animals
  6. Thankachan S, Katsuki F, McKenna JT, Yang C, Shukla C, Deisseroth K, Uygun DS, Strecker RE, Brown RE, McNally JM, Basheer R. Thalamic Reticular Nucleus Parvalbumin Neurons Regulate Sleep Spindles and Electrophysiological Aspects of Schizophrenia in Mice. Sci Rep. 2019 03 05; 9(1):3607. PMID: 30837664.
    Citations: 18     Fields:    Translation:AnimalsCells
  7. Uygun DS, Katsuki F, Bolortuya Y, Aguilar DD, McKenna JT, Thankachan S, McCarley RW, Basheer R, Brown RE, Strecker RE, McNally JM. Validation of an automated sleep spindle detection method for mouse electroencephalography. Sleep. 2019 02 01; 42(2). PMID: 30476300.
    Citations: 13     Fields:    Translation:HumansAnimals
  8. Yang C, Larin A, McKenna JT, Jacobson KA, Winston S, Strecker RE, Kalinchuk A, Basheer R, Brown RE. Activation of basal forebrain purinergic P2 receptors promotes wakefulness in mice. Sci Rep. 2018 Jul 16; 8(1):10730. PMID: 30013200.
    Citations: 1     Fields:    Translation:AnimalsCells
  9. Dworak M, Kim T, Mccarley RW, Basheer R. Creatine supplementation reduces sleep need and homeostatic sleep pressure in rats. J Sleep Res. 2017 06; 26(3):377-385. PMID: 28397310.
    Citations: 4     Fields:    Translation:Animals
  10. Zielinski MR, Gerashchenko D, Karpova SA, Konanki V, McCarley RW, Sutterwala FS, Strecker RE, Basheer R. The NLRP3 inflammasome modulates sleep and NREM sleep delta power induced by spontaneous wakefulness, sleep deprivation and lipopolysaccharide. Brain Behav Immun. 2017 May; 62:137-150. PMID: 28109896.
    Citations: 16     Fields:    Translation:AnimalsCells
  11. Gvilia I, Suntsova N, Kostin A, Kalinchuk A, McGinty D, Basheer R, Szymusiak R. The role of adenosine in the maturation of sleep homeostasis in rats. J Neurophysiol. 2017 01 01; 117(1):327-335. PMID: 27784808.
    Citations: 5     Fields:    Translation:Animals
  12. Zant JC, Kim T, Prokai L, Szarka S, McNally J, McKenna JT, Shukla C, Yang C, Kalinchuk AV, McCarley RW, Brown RE, Basheer R. Cholinergic Neurons in the Basal Forebrain Promote Wakefulness by Actions on Neighboring Non-Cholinergic Neurons: An Opto-Dialysis Study. J Neurosci. 2016 Feb 10; 36(6):2057-67. PMID: 26865627; PMCID: PMC4748083.
    Citations: 35     Fields:    Translation:AnimalsCells
  13. Shukla C, Basheer R. Metabolic signals in sleep regulation: recent insights. Nat Sci Sleep. 2016; 8:9-20. PMID: 26793010; PMCID: PMC4708875.
    Citations: 7     
  14. Kim T, Ramesh V, Dworak M, Choi DS, McCarley RW, Kalinchuk AV, Basheer R. Disrupted sleep-wake regulation in type 1 equilibrative nucleoside transporter knockout mice. Neuroscience. 2015 Sep 10; 303:211-9. PMID: 26143012.
    Citations: 8     Fields:    Translation:Animals
  15. Kim T, Thankachan S, McKenna JT, McNally JM, Yang C, Choi JH, Chen L, Kocsis B, Deisseroth K, Strecker RE, Basheer R, Brown RE, McCarley RW. Cortically projecting basal forebrain parvalbumin neurons regulate cortical gamma band oscillations. Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11):3535-40. PMID: 25733878.
    Citations: 115     Fields:    Translation:AnimalsCells
  16. Kalinchuk AV, Porkka-Heiskanen T, McCarley RW, Basheer R. Cholinergic neurons of the basal forebrain mediate biochemical and electrophysiological mechanisms underlying sleep homeostasis. Eur J Neurosci. 2015 Jan; 41(2):182-95. PMID: 25369989; PMCID: PMC4460789.
    Citations: 21     Fields:    Translation:AnimalsCells
  17. Yang C, McKenna JT, Zant JC, Winston S, Basheer R, Brown RE. Cholinergic neurons excite cortically projecting basal forebrain GABAergic neurons. J Neurosci. 2014 Feb 19; 34(8):2832-44. PMID: 24553925.
    Citations: 41     Fields:    Translation:AnimalsCells
  18. Brown RE, Basheer R, McKenna JT, Strecker RE, McCarley RW. Control of sleep and wakefulness. Physiol Rev. 2012 Jul; 92(3):1087-187. PMID: 22811426.
    Citations: 419     Fields:    Translation:HumansAnimalsCells
  19. Kim Y, Bolortuya Y, Chen L, Basheer R, McCarley RW, Strecker RE. Decoupling of sleepiness from sleep time and intensity during chronic sleep restriction: evidence for a role of the adenosine system. Sleep. 2012 Jun 01; 35(6):861-9. PMID: 22654205.
    Citations: 25     Fields:    Translation:Animals
  20. Dworak M, McCarley RW, Kim T, Basheer R. Delta oscillations induced by ketamine increase energy levels in sleep-wake related brain regions. Neuroscience. 2011 Dec 01; 197:72-9. PMID: 21958867.
    Citations: 6     Fields:    Translation:Animals
  21. Dworak M, McCarley RW, Kim T, Kalinchuk AV, Basheer R. Replies to commentaries on ATP changes during sleep. Sleep. 2011 Jul 01; 34(7):841-3. PMID: 21731133.
    Citations: 5     Fields:    Translation:HumansAnimals
  22. Dworak M, Kim T, McCarley RW, Basheer R. Sleep, brain energy levels, and food intake: Relationship between hypothalamic ATP concentrations, food intake, and body weight during sleep-wake and sleep deprivation in rats. Somnologie (Berl). 2011 Jun; 15(2):111-117. PMID: 23585726.
    Citations: 8     
  23. Kalinchuk AV, McCarley RW, Porkka-Heiskanen T, Basheer R. The time course of adenosine, nitric oxide (NO) and inducible NO synthase changes in the brain with sleep loss and their role in the non-rapid eye movement sleep homeostatic cascade. J Neurochem. 2011 Jan; 116(2):260-72. PMID: 21062286.
    Citations: 37     Fields:    Translation:Animals
  24. Chen L, McKenna JT, Bolortuya Y, Winston S, Thakkar MM, Basheer R, Brown RE, McCarley RW. Knockdown of orexin type 1 receptor in rat locus coeruleus increases REM sleep during the dark period. Eur J Neurosci. 2010 Nov; 32(9):1528-36. PMID: 21089218.
    Citations: 18     Fields:    Translation:Animals
  25. Kalinchuk AV, McCarley RW, Porkka-Heiskanen T, Basheer R. Sleep deprivation triggers inducible nitric oxide-dependent nitric oxide production in wake-active basal forebrain neurons. J Neurosci. 2010 Oct 06; 30(40):13254-64. PMID: 20926651.
    Citations: 35     Fields:    Translation:AnimalsCells
  26. Dworak M, McCarley RW, Kim T, Kalinchuk AV, Basheer R. Sleep and brain energy levels: ATP changes during sleep. J Neurosci. 2010 Jun 30; 30(26):9007-16. PMID: 20592221.
    Citations: 102     Fields:    Translation:AnimalsCells
  27. Elmenhorst D, Basheer R, McCarley RW, Bauer A. Sleep deprivation increases A(1) adenosine receptor density in the rat brain. Brain Res. 2009 Mar 03; 1258:53-8. PMID: 19146833.
    Citations: 29     Fields:    Translation:Animals
  28. Kalinchuk AV, McCarley RW, Stenberg D, Porkka-Heiskanen T, Basheer R. The role of cholinergic basal forebrain neurons in adenosine-mediated homeostatic control of sleep: lessons from 192 IgG-saporin lesions. Neuroscience. 2008 Nov 11; 157(1):238-53. PMID: 18805464.
    Citations: 30     Fields:    Translation:AnimalsCells
  29. Brown RE, McKenna JT, Winston S, Basheer R, Yanagawa Y, Thakkar MM, McCarley RW. Characterization of GABAergic neurons in rapid-eye-movement sleep controlling regions of the brainstem reticular formation in GAD67-green fluorescent protein knock-in mice. Eur J Neurosci. 2008 Jan; 27(2):352-63. PMID: 18215233.
    Citations: 44     Fields:    Translation:AnimalsCells
  30. Basheer R, Bauer A, Elmenhorst D, Ramesh V, McCarley RW. Sleep deprivation upregulates A1 adenosine receptors in the rat basal forebrain. Neuroreport. 2007 Dec 03; 18(18):1895-9. PMID: 18007182.
    Citations: 31     Fields:    Translation:AnimalsCells
  31. Ramesh V, Thatte HS, McCarley RW, Basheer R. Adenosine and sleep deprivation promote NF-kappaB nuclear translocation in cholinergic basal forebrain. J Neurochem. 2007 Mar; 100(5):1351-63. PMID: 17316404.
    Citations: 18     Fields:    Translation:AnimalsCells
  32. Elmenhorst D, Meyer PT, Winz OH, Matusch A, Ermert J, Coenen HH, Basheer R, Haas HL, Zilles K, Bauer A. Sleep deprivation increases A1 adenosine receptor binding in the human brain: a positron emission tomography study. J Neurosci. 2007 Feb 28; 27(9):2410-5. PMID: 17329439; PMCID: PMC6673478.
    Citations: 66     Fields:    Translation:Humans
  33. Chen L, Thakkar MM, Winston S, Bolortuya Y, Basheer R, McCarley RW. REM sleep changes in rats induced by siRNA-mediated orexin knockdown. Eur J Neurosci. 2006 Oct; 24(7):2039-48. PMID: 17067300; PMCID: PMC2394504.
    Citations: 34     Fields:    Translation:Animals
  34. Brown RE, Winston S, Basheer R, Thakkar MM, McCarley RW. Electrophysiological characterization of neurons in the dorsolateral pontine rapid-eye-movement sleep induction zone of the rat: Intrinsic membrane properties and responses to carbachol and orexins. Neuroscience. 2006 Dec; 143(3):739-55. PMID: 17008019.
    Citations: 32     Fields:    Translation:AnimalsCells
  35. Strecker RE, Basheer R, McKenna JT, McCarley RW. Another chapter in the adenosine story. Sleep. 2006 Apr; 29(4):426-8. PMID: 16676774.
    Citations: 4     Fields:    Translation:Humans
  36. Basheer R, Brown R, Ramesh V, Begum S, McCarley RW. Sleep deprivation-induced protein changes in basal forebrain: implications for synaptic plasticity. J Neurosci Res. 2005 Dec 01; 82(5):650-8. PMID: 16273548.
    Citations: 28     Fields:    Translation:AnimalsCells
  37. Basheer R, Strecker RE, Thakkar MM, McCarley RW. Adenosine and sleep-wake regulation. Prog Neurobiol. 2004 Aug; 73(6):379-96. PMID: 15313333.
    Citations: 181     Fields:    Translation:HumansAnimals
  38. Ramesh V, Thakkar MM, Strecker RE, Basheer R, McCarley RW. Wakefulness-inducing effects of histamine in the basal forebrain of freely moving rats. Behav Brain Res. 2004 Jul 09; 152(2):271-8. PMID: 15196795.
    Citations: 15     Fields:    Translation:Animals
  39. Basheer R, Arrigoni E, Thatte HS, Greene RW, Ambudkar IS, McCarley RW. Adenosine induces inositol 1,4,5-trisphosphate receptor-mediated mobilization of intracellular calcium stores in basal forebrain cholinergic neurons. J Neurosci. 2002 Sep 01; 22(17):7680-6. PMID: 12196591; PMCID: PMC6758010.
    Citations: 17     Fields:    Translation:AnimalsCells
  40. Basheer R, Halldner L, Alanko L, McCarley RW, Fredholm BB, Porkka-Heiskanen T. Opposite changes in adenosine A1 and A2A receptor mRNA in the rat following sleep deprivation. Neuroreport. 2001 Jun 13; 12(8):1577-80. PMID: 11409719.
    Citations: 26     Fields:    Translation:Animals
  41. Basheer R, Shiromani PJ. Effects of prolonged wakefulness on c-fos and AP1 activity in young and old rats. Brain Res Mol Brain Res. 2001 Apr 18; 89(1-2):153-7. PMID: 11311986.
    Citations: 6     Fields:    Translation:Animals
  42. Basheer R, Rainnie DG, Porkka-Heiskanen T, Ramesh V, McCarley RW. Adenosine, prolonged wakefulness, and A1-activated NF-kappaB DNA binding in the basal forebrain of the rat. Neuroscience. 2001; 104(3):731-9. PMID: 11440805.
    Citations: 27     Fields:    Translation:AnimalsCells
  43. Basheer R, Porkka-Heiskanen T, Strecker RE, Thakkar MM, McCarley RW. Adenosine as a biological signal mediating sleepiness following prolonged wakefulness. Biol Signals Recept. 2000 Nov-Dec; 9(6):319-27. PMID: 11025338.
    Citations: 19     Fields:    
  44. Strecker RE, Morairty S, Thakkar MM, Porkka-Heiskanen T, Basheer R, Dauphin LJ, Rainnie DG, Portas CM, Greene RW, McCarley RW. Adenosinergic modulation of basal forebrain and preoptic/anterior hypothalamic neuronal activity in the control of behavioral state. Behav Brain Res. 2000 Nov; 115(2):183-204. PMID: 11000420.
    Citations: 80     Fields:    Translation:AnimalsCells
  45. Shiromani PJ, Basheer R, Thakkar J, Wagner D, Greco MA, Charness ME. Sleep and wakefulness in c-fos and fos B gene knockout mice. Brain Res Mol Brain Res. 2000 Aug 14; 80(1):75-87. PMID: 11039731.
    Citations: 8     Fields:    Translation:Animals
  46. Shiromani PJ, Lu J, Wagner D, Thakkar J, Greco MA, Basheer R, Thakkar M. Compensatory sleep response to 12 h wakefulness in young and old rats. Am J Physiol Regul Integr Comp Physiol. 2000 Jan; 278(1):R125-33. PMID: 10644630.
    Citations: 28     Fields:    Translation:Animals
  47. Basheer R, Porkka-Heiskanen T, Stenberg D, McCarley RW. Adenosine and behavioral state control: adenosine increases c-Fos protein and AP1 binding in basal forebrain of rats. Brain Res Mol Brain Res. 1999 Nov 10; 73(1-2):1-10. PMID: 10581392.
    Citations: 37     Fields:    Translation:AnimalsCells
  48. Basheer R, Magner M, McCarley RW, Shiromani PJ. REM sleep deprivation increases the levels of tyrosine hydroxylase and norepinephrine transporter mRNA in the locus coeruleus. Brain Res Mol Brain Res. 1998 Jun 15; 57(2):235-40. PMID: 9675421.
    Citations: 14     Fields:    Translation:Animals
  49. Basheer R, Sherin JE, Saper CB, Morgan JI, McCarley RW, Shiromani PJ. Effects of sleep on wake-induced c-fos expression. J Neurosci. 1997 Dec 15; 17(24):9746-50. PMID: 9391027; PMCID: PMC6573405.
    Citations: 25     Fields:    Translation:Animals
  50. Tempel A, Yang J, Basheer R. Prenatal morphine exposure differentially alters expression of opioid peptides in striatum of newborns. Brain Res Mol Brain Res. 1995 Nov; 33(2):227-32. PMID: 8750881.
    Citations: 5     Fields:    Translation:AnimalsCells
  51. Basheer R, Tempel A. Morphine-induced reciprocal alterations in G alpha s and opioid peptide mRNA levels in discrete brain regions. J Neurosci Res. 1993 Dec 01; 36(5):551-7. PMID: 7908338.
    Citations: 3     Fields:    Translation:Animals
  52. Basheer R, Yang J, Tempel A. Chronic prenatal morphine treatment decreases G alpha s mRNA levels in neonatal frontal cortex. Brain Res Dev Brain Res. 1992 Nov 20; 70(1):145-8. PMID: 1473274.
    Citations: 3     Fields:    Translation:Animals
  53. Iordanescu S, Basheer R. The Staphylococcus aureus mutation pcrA3 leads to the accumulation of pT181 replication initiation complexes. J Mol Biol. 1991 Oct 20; 221(4):1183-9. PMID: 1942047.
    Citations: 11     Fields:    Translation:Cells
  54. Basheer R, Iordanescu S. The Staphylococcus aureus chromosomal gene plaC, identified by mutations amplifying plasmid pT181, encodes a sigma factor. Nucleic Acids Res. 1991 Sep 25; 19(18):4921-4. PMID: 1923759; PMCID: PMC328790.
    Citations: 4     Fields:    Translation:Cells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.