Harvard Catalyst Profiles

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Zhe Li, PH.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01CA222560 (LI, ZHE) Dec 12, 2017 - Nov 30, 2022
    NIH/NCI
    Interplay of mammary luminal cells and environmental factors in establishing p53-deficient premalignant field
    Role: Principal Investigator
  2. UH2CA213392 (LI, ZHE) Sep 16, 2016 - Aug 31, 2018
    NIH/NCI
    Impact of aging on prostate cancer with TMPRSS2-ETS gene fusion
    Role: Principal Investigator
  3. R21CA205825 (LI, ZHE) Apr 15, 2016 - Mar 31, 2018
    NIH/NCI
    CRISPR/Cas9-based lineage tracing for fate mapping of cancer cells and stem cells
    Role: Principal Investigator
  4. R21DE024395 (LI, ZHE) Jul 10, 2014 - Jun 30, 2016
    NIH/NIDCR
    Lineage tracing and clonal analysis of oral cancer initiating cells
    Role: Principal Investigator
  5. R01HL107663 (LI, ZHE) Jun 1, 2011 - Mar 31, 2016
    NIH/NHLBI
    IGF/IGF1R signaling in hematopoiesis and leukemogenesis
    Role: Principal Investigator
This researcher has shared information about their research resources in the eagle-i Network. To update or add resource records, contact eagle-i@hms.harvard.edu.
Li Lab - Mouse strains (9)

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Tao L, Xiang D, Xie Y, Bronson RT, Li Z. Induced p53 loss in mouse luminal cells causes clonal expansion and development of mammary tumours. Nat Commun. 2017 02 13; 8:14431. PMID: 28194015.
    View in: PubMed
  2. Pakula H, Xiang D, Li Z. A Tale of Two Signals: AR and WNT in Development and Tumorigenesis of Prostate and Mammary Gland. Cancers (Basel). 2017 Jan 27; 9(2). PMID: 28134791.
    View in: PubMed
  3. Chimge NO, Little GH, Baniwal SK, Adisetiyo H, Xie Y, Zhang T, O'Laughlin A, Liu ZY, Ulrich P, Martin A, Mhawech-Fauceglia P, Ellis MJ, Tripathy D, Groshen S, Liang C, Li Z, Schones DE, Frenkel B. RUNX1 prevents oestrogen-mediated AXIN1 suppression and ß-catenin activation in ER-positive breast cancer. Nat Commun. 2016 Feb 26; 7:10751. PMID: 26916619; PMCID: PMC4773428.
  4. Linn DE, Penney KL, Bronson RT, Mucci LA, Li Z. Deletion of Interstitial Genes between TMPRSS2 and ERG Promotes Prostate Cancer Progression. Cancer Res. 2016 04 01; 76(7):1869-81. PMID: 26880803; PMCID: PMC4873435 [Available on 04/01/17].
  5. Tao L, van Bragt MP, Li Z. A Long-Lived Luminal Subpopulation Enriched with Alveolar Progenitors Serves as Cellular Origin of Heterogeneous Mammary Tumors. Stem Cell Reports. 2015 Jul 14; 5(1):60-74. PMID: 26120057; PMCID: PMC4618443.
  6. Linn DE, Bronson RT, Li Z. Genetic interaction between Tmprss2-ERG gene fusion and Nkx3.1-loss does not enhance prostate tumorigenesis in mouse models. PLoS One. 2015; 10(3):e0120628. PMID: 25780911; PMCID: PMC4364018.
  7. van Bragt MP, Hu X, Xie Y, Li Z. RUNX1, a transcription factor mutated in breast cancer, controls the fate of ER-positive mammary luminal cells. Elife. 2014 Nov 21; 3:e03881. PMID: 25415051; PMCID: PMC4381933.
  8. Tao L, van Bragt MP, Laudadio E, Li Z. Lineage tracing of mammary epithelial cells using cell-type-specific cre-expressing adenoviruses. Stem Cell Reports. 2014 Jun 03; 2(6):770-9. PMID: 24936465; PMCID: PMC4050356.
  9. Emmrich S, Rasche M, Schöning J, Reimer C, Keihani S, Maroz A, Xie Y, Li Z, Schambach A, Reinhardt D, Klusmann JH. miR-99a/100~125b tricistrons regulate hematopoietic stem and progenitor cell homeostasis by shifting the balance between TGFß and Wnt signaling. Genes Dev. 2014 Apr 15; 28(8):858-74. PMID: 24736844; PMCID: PMC4003278.
  10. Forster N, Saladi SV, van Bragt M, Sfondouris ME, Jones FE, Li Z, Ellisen LW. Basal cell signaling by p63 controls luminal progenitor function and lactation via NRG1. Dev Cell. 2014 Jan 27; 28(2):147-60. PMID: 24412575; PMCID: PMC3951056.
  11. Elagib KE, Rubinstein JD, Delehanty LL, Ngoh VS, Greer PA, Li S, Lee JK, Li Z, Orkin SH, Mihaylov IS, Goldfarb AN. Calpain 2 activation of P-TEFb drives megakaryocyte morphogenesis and is disrupted by leukemogenic GATA1 mutation. Dev Cell. 2013 Dec 23; 27(6):607-20. PMID: 24369834; PMCID: PMC3892434.
  12. Maroz A, Stachorski L, Emmrich S, Reinhardt K, Xu J, Shao Z, Käbler S, Dertmann T, Hitzler J, Roberts I, Vyas P, Juban G, Hennig C, Hansen G, Li Z, Orkin S, Reinhardt D, Klusmann JH. GATA1s induces hyperproliferation of eosinophil precursors in Down syndrome transient leukemia. Leukemia. 2014 Jun; 28(6):1259-70. PMID: 24336126; PMCID: PMC4047213.
  13. Stankov MV, El Khatib M, Kumar Thakur B, Heitmann K, Panayotova-Dimitrova D, Schoening J, Bourquin JP, Schweitzer N, Leverkus M, Welte K, Reinhardt D, Li Z, Orkin SH, Behrens GM, Klusmann JH. Histone deacetylase inhibitors induce apoptosis in myeloid leukemia by suppressing autophagy. Leukemia. 2014 Mar; 28(3):577-88. PMID: 24080946; PMCID: PMC3947652.
  14. Baena E, Shao Z, Linn DE, Glass K, Hamblen MJ, Fujiwara Y, Kim J, Nguyen M, Zhang X, Godinho FJ, Bronson RT, Mucci LA, Loda M, Yuan GC, Orkin SH, Li Z. ETV1 directs androgen metabolism and confers aggressive prostate cancer in targeted mice and patients. Genes Dev. 2013 Mar 15; 27(6):683-98. PMID: 23512661; PMCID: PMC3613614.
  15. Klusmann JH, Godinho FJ, Heitmann K, Maroz A, Koch ML, Reinhardt D, Orkin SH, Li Z. Developmental stage-specific interplay of GATA1 and IGF signaling in fetal megakaryopoiesis and leukemogenesis. Genes Dev. 2010 Aug 01; 24(15):1659-72. PMID: 20679399; PMCID: PMC2912563.
  16. Klusmann JH, Li Z, Böhmer K, Maroz A, Koch ML, Emmrich S, Godinho FJ, Orkin SH, Reinhardt D. miR-125b-2 is a potential oncomiR on human chromosome 21 in megakaryoblastic leukemia. Genes Dev. 2010 Mar 01; 24(5):478-90. PMID: 20194440; PMCID: PMC2827843.
  17. Alford KA, Slender A, Vanes L, Li Z, Fisher EM, Nizetic D, Orkin SH, Roberts I, Tybulewicz VL. Perturbed hematopoiesis in the Tc1 mouse model of Down syndrome. Blood. 2010 Apr 08; 115(14):2928-37. PMID: 20154221; PMCID: PMC2854435.
  18. Huang Z, Dore LC, Li Z, Orkin SH, Feng G, Lin S, Crispino JD. GATA-2 reinforces megakaryocyte development in the absence of GATA-1. Mol Cell Biol. 2009 Sep; 29(18):5168-80. PMID: 19620289; PMCID: PMC2738300.
  19. Li Z, Tognon CE, Godinho FJ, Yasaitis L, Hock H, Herschkowitz JI, Lannon CL, Cho E, Kim SJ, Bronson RT, Perou CM, Sorensen PH, Orkin SH. ETV6-NTRK3 fusion oncogene initiates breast cancer from committed mammary progenitors via activation of AP1 complex. Cancer Cell. 2007 Dec; 12(6):542-58. PMID: 18068631; PMCID: PMC2175032.
  20. Li Z, Lukasik SM, Liu Y, Grembecka J, Bielnicka I, Bushweller JH, Speck NA. A mutation in the S-switch region of the Runt domain alters the dynamics of an allosteric network responsible for CBFbeta regulation. J Mol Biol. 2006 Dec 15; 364(5):1073-83. PMID: 17059830.
    View in: PubMed
  21. Talebian L, Li Z, Guo Y, Gaudet J, Speck ME, Sugiyama D, Kaur P, Pear WS, Maillard I, Speck NA. T-lymphoid, megakaryocyte, and granulocyte development are sensitive to decreases in CBFbeta dosage. Blood. 2007 Jan 01; 109(1):11-21. PMID: 16940420; PMCID: PMC1785070.
  22. Chen CL, Broom DC, Liu Y, de Nooij JC, Li Z, Cen C, Samad OA, Jessell TM, Woolf CJ, Ma Q. Runx1 determines nociceptive sensory neuron phenotype and is required for thermal and neuropathic pain. Neuron. 2006 Feb 02; 49(3):365-77. PMID: 16446141.
    View in: PubMed
  23. Li Z, Chen MJ, Stacy T, Speck NA. Runx1 function in hematopoiesis is required in cells that express Tek. Blood. 2006 Jan 01; 107(1):106-10. PMID: 16174759; PMCID: PMC1895353.
  24. Li Z, Godinho FJ, Klusmann JH, Garriga-Canut M, Yu C, Orkin SH. Developmental stage-selective effect of somatically mutated leukemogenic transcription factor GATA1. Nat Genet. 2005 Jun; 37(6):613-9. PMID: 15895080.
    View in: PubMed
  25. Growney JD, Shigematsu H, Li Z, Lee BH, Adelsperger J, Rowan R, Curley DP, Kutok JL, Akashi K, Williams IR, Speck NA, Gilliland DG. Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype. Blood. 2005 Jul 15; 106(2):494-504. PMID: 15784726; PMCID: PMC1895175.
  26. Yamashiro T, Wang XP, Li Z, Oya S, Aberg T, Fukunaga T, Kamioka H, Speck NA, Takano-Yamamoto T, Thesleff I. Possible roles of Runx1 and Sox9 in incipient intramembranous ossification. J Bone Miner Res. 2004 Oct; 19(10):1671-7. PMID: 15355562.
    View in: PubMed
  27. Zhang L, Li Z, Yan J, Pradhan P, Corpora T, Cheney MD, Bravo J, Warren AJ, Bushweller JH, Speck NA. Mutagenesis of the Runt domain defines two energetic hot spots for heterodimerization with the core binding factor beta subunit. J Biol Chem. 2003 Aug 29; 278(35):33097-104. PMID: 12807883.
    View in: PubMed
  28. Li Z, Yan J, Matheny CJ, Corpora T, Bravo J, Warren AJ, Bushweller JH, Speck NA. Energetic contribution of residues in the Runx1 Runt domain to DNA binding. J Biol Chem. 2003 Aug 29; 278(35):33088-96. PMID: 12807882.
    View in: PubMed
  29. Bravo J, Li Z, Speck NA, Warren AJ. The leukemia-associated AML1 (Runx1)--CBF beta complex functions as a DNA-induced molecular clamp. Nat Struct Biol. 2001 Apr; 8(4):371-8. PMID: 11276260.
    View in: PubMed
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.