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John L. Neumeyer, PH.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R44OD024615 (NEUMEYER, JOHN L) May 5, 2017 - Apr 30, 2019
    NIH
    Preclinical Validation of Novel High Affinity D2 Receptor Agonists for PET Neuroimaging
    Role: Principal Investigator
  2. R43OD020186 (NEUMEYER, JOHN L) Sep 1, 2014 - Feb 28, 2015
    NIH
    Development of a Tritiated Agonist Radioligand for the D2 Receptor
    Role: Principal Investigator
  3. R01DA014251 (NEUMEYER, JOHN L) Sep 1, 2001 - Jan 31, 2014
    NIH/NIDA
    Mixed Kappa-Mu Opioids: Synthesis and Evaluation
    Role: Principal Investigator
  4. R44DA013311 (NEUMEYER, JOHN L) Sep 30, 2000 - Aug 31, 2003
    NIH/NIDA
    DOPAMINE AGONISTS FOR THE THERAPY OF COCAINE ADDICTION
    Role: Principal Investigator
  5. R44NS040587 (NEUMEYER, JOHN L) Jun 1, 2000 - Mar 30, 2005
    NIH/NINDS
    Dopamine Transporter Imaging with Fluorine-18 PET
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Xu Y, Sromek AW, Neumeyer JL. Identification of fluorinated (R)-(-)-aporphine derivatives as potent and selective ligands at serotonin 5-HT2C receptor. Bioorg Med Chem Lett. 2019 Jan 15; 29(2):230-233. PMID: 30545651.
    Citations:    Fields:    
  2. Subburaju S, Sromek AW, Seeman P, Neumeyer JL. New Dopamine D2 Receptor Agonist, [3H]MCL-536, for Detecting Dopamine D2high Receptors in Vivo. ACS Chem Neurosci. 2018 06 20; 9(6):1283-1289. PMID: 29641175.
    Citations:    Fields:    
  3. Lincoln L, Fisher R, Jackson MJ, Jenner P, Neumeyer J, Sromek AW, Lees AJ, Rose S. Oral r-(-)-11-o-valeryl-n-n-propylnoraporphine reverses motor deficits in mptp-treated marmosets. Mov Disord. 2016 09; 31(9):1381-8. PMID: 27133947.
    Citations: 1     Fields:    Translation:Animals
  4. Sromek AW, Zhang S, Akurathi V, Packard AB, Li W, Alagille D, Morley TJ, Baldwin R, Tamagnan G, Neumeyer JL. Convenient synthesis of 18F-radiolabeled R-(-)-N-n-propyl-2-(3-fluoropropanoxy-11-hydroxynoraporphine. J Labelled Comp Radiopharm. 2014 Dec; 57(14):725-9. PMID: 25400260.
    Citations: 1     Fields:    
  5. Sun JF, Wang YH, Chai JR, Li FY, Hang A, Lu G, Tao YM, Cheng Y, Chi ZQ, Neumeyer JL, Zhang A, Liu JG, Wang YJ. Pharmacological characterization and therapeutic potential for the treatment of opioid abuse with ATPM-ET, an N-ethyl substituted aminothiazolomorphinan with ? agonist and µ agonist/antagonist activity. Eur J Pharmacol. 2014 Oct 05; 740:455-63. PMID: 24998879.
    Citations: 1     Fields:    Translation:Animals
  6. Finnema SJ, Stepanov V, Nakao R, Sromek AW, Zhang T, Neumeyer JL, George SR, Seeman P, Stabin MG, Jonsson C, Farde L, Halldin C. (18)F-MCL-524, an (18)F-Labeled Dopamine D2 and D3 Receptor Agonist Sensitive to Dopamine: A Preliminary PET Study. J Nucl Med. 2014 Jul; 55(7):1164-70. PMID: 24790219.
    Citations: 5     Fields:    Translation:Animals
  7. Sromek AW, Provencher BA, Russell S, Chartoff E, Knapp BI, Bidlack JM, Neumeyer JL. Preliminary pharmacological evaluation of enantiomeric morphinans. ACS Chem Neurosci. 2014 Feb 19; 5(2):93-9. PMID: 24393077.
    Citations: 2     Fields:    Translation:HumansAnimals
  8. Provencher BA, Sromek AW, Li W, Russell S, Chartoff E, Knapp BI, Bidlack JM, Neumeyer JL. Synthesis and pharmacological evaluation of aminothiazolomorphinans at the mu and kappa opioid receptors. J Med Chem. 2013 Nov 14; 56(21):8872-8. PMID: 24107104.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  9. Ye N, Neumeyer JL, Baldessarini RJ, Zhen X, Zhang A. Update 1 of: Recent progress in development of dopamine receptor subtype-selective agents: potential therapeutics for neurological and psychiatric disorders. Chem Rev. 2013 May 08; 113(5):PR123-78. PMID: 23464812.
    Citations: 10     Fields:    Translation:HumansAnimals
  10. Neumeyer JL, Zhang B, Zhang T, Sromek AW, Knapp BI, Cohen DJ, Bidlack JM. Synthesis, binding affinity, and functional in vitro activity of 3-benzylaminomorphinan and 3-benzylaminomorphine ligands at opioid receptors. J Med Chem. 2012 Apr 26; 55(8):3878-90. PMID: 22439881.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  11. Neumeyer JL. A tribute to Joseph G. Cannon, 1926-2011. J Med Chem. 2012 Feb 23; 55(4):1423. PMID: 22309148.
    Citations:    Fields:    
  12. Zhang B, Zhang T, Sromek AW, Scrimale T, Bidlack JM, Neumeyer JL. Synthesis and binding affinity of novel mono- and bivalent morphinan ligands for ?, µ, and d opioid receptors. Bioorg Med Chem. 2011 May 01; 19(9):2808-16. PMID: 21482470.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  13. Sromek AW, Si YG, Zhang T, George SR, Seeman P, Neumeyer JL. Synthesis and Evaluation of Fluorinated Aporphines: Potential Positron Emission Tomography Ligands for D2 Receptors ACS Med Chem Lett. 2011 Mar 10; 2(3):189-194. PMID: 21666830.
    Citations: 2     
  14. Zhang T, Yan Z, Sromek A, Knapp BI, Scrimale T, Bidlack JM, Neumeyer JL. Aminothiazolomorphinans with mixed ? and µ opioid activity. J Med Chem. 2011 Mar 24; 54(6):1903-13. PMID: 21351746.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  15. Balboni G, Salvadori S, Marczak ED, Knapp BI, Bidlack JM, Lazarus LH, Peng X, Si YG, Neumeyer JL. Opioid bifunctional ligands from morphine and the opioid pharmacophore Dmt-Tic. Eur J Med Chem. 2011 Feb; 46(2):799-803. PMID: 21216504.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  16. SUN JF, WANG YH, LI FY, LU G, TAO YM, CHENG Y, CHEN J, XU XJ, CHI ZQ, NEUMEYER JL, ZHANG A, LIU JG. Effects of ATPM-ET, a novel ? agonist with partial µ activity, on physical dependence and behavior sensitization in mice. Acta Pharmacol Sin. 2010 Dec; 31(12):1547-52. PMID: 21102484.
    Citations: 3     Fields:    Translation:Animals
  17. Hupp CD, Neumeyer JL. Rapid access to morphinones: removal of 4, 5-ether bridge with Pd-catalyzed triflate reduction. Tetrahedron Lett. 2010 Apr 28; 51(17):2359-2361. PMID: 20495617.
    Citations: 3     Fields:    
  18. Balboni G, Salvadori S, Trapella C, Knapp BI, Bidlack JM, Lazarus LH, Peng X, Neumeyer JL. Evolution of the Bifunctional Lead µ Agonist / d Antagonist Containing the Dmt-Tic Opioid Pharmacophore. ACS Chem Neurosci. 2010 Feb 17; 1(2):155-164. PMID: 20352071.
    Citations: 15     Fields:    
  19. Fulton BS, Knapp BL, Bidlack JM, Neumeyer JL. Effect of linker substitution on the binding of butorphan univalent and bivalent ligands to opioid receptors. Bioorg Med Chem Lett. 2010 Mar 01; 20(5):1507-9. PMID: 20144870.
    Citations: 2     Fields:    Translation:AnimalsCells
  20. Decker M, Si YG, Knapp BI, Bidlack JM, Neumeyer JL. Synthesis and opioid receptor binding affinities of 2-substituted and 3-aminomorphinans: ligands for mu, kappa, and delta opioid receptors. J Med Chem. 2010 Jan 14; 53(1):402-18. PMID: 19928862.
    Citations: 4     Fields:    Translation:Cells
  21. Decker M, Fulton BS, Zhang B, Knapp BI, Bidlack JM, Neumeyer JL. Univalent and bivalent ligands of butorphan: characteristics of the linking chain determine the affinity and potency of such opioid ligands. J Med Chem. 2009 Dec 10; 52(23):7389-96. PMID: 19634902.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  22. Chen XQ, Zhang J, Neumeyer JL, Jin GZ, Hu GY, Zhang A, Zhen X. Arylbenzazepines are potent modulators for the delayed rectifier K+ channel: a potential mechanism for their neuroprotective effects. PLoS One. 2009 Jun 05; 4(6):e5811. PMID: 19503734.
    Citations: 5     Fields:    Translation:AnimalsCells
  23. Wang YJ, Tao YM, Li FY, Wang YH, Xu XJ, Chen J, Cao YL, Chi ZQ, Neumeyer JL, Zhang A, Liu JG. Pharmacological characterization of ATPM [(-)-3-aminothiazolo[5,4-b]-N-cyclopropylmethylmorphinan hydrochloride], a novel mixed kappa-agonist and mu-agonist/-antagonist that attenuates morphine antinociceptive tolerance and heroin self-administration behavior. J Pharmacol Exp Ther. 2009 Apr; 329(1):306-13. PMID: 19136637.
    Citations: 7     Fields:    Translation:Animals
  24. Si YG, Choi YK, Gardner MP, Tarazi FI, Baldessarini RJ, Neumeyer JL. Synthesis and neuropharmacological evaluation of esters of R(-)-N-alkyl-11-hydroxy-2-methoxynoraporphines. Bioorg Med Chem Lett. 2009 Jan 01; 19(1):51-3. PMID: 19058967.
    Citations:    Fields:    Translation:AnimalsCells
  25. Fulton BS, Knapp BI, Bidlack JM, Neumeyer JL. Synthesis and pharmacological evaluation of hydrophobic esters and ethers of butorphanol at opioid receptors. Bioorg Med Chem Lett. 2008 Aug 15; 18(16):4474-6. PMID: 18674902.
    Citations: 1     Fields:    Translation:AnimalsCells
  26. Si YG, Gardner MP, Tarazi FI, Baldessarini RJ, Neumeyer JL. Synthesis and binding studies of 2-O- and 11-O-substituted N-alkylnoraporphines. Bioorg Med Chem Lett. 2008 Jul 15; 18(14):3971-3. PMID: 18585036.
    Citations: 4     Fields:    Translation:AnimalsCells
  27. Mathews JL, Fulton BS, Negus SS, Neumeyer JL, Bidlack JM. In vivo characterization of (-)(-)MCL-144 and (+)(-)MCL-193: isomeric, bivalent ligands with mu/kappa agonist properties. Neurochem Res. 2008 Oct; 33(10):2142-50. PMID: 18528756.
    Citations: 4     Fields:    Translation:AnimalsCells
  28. Si YG, Gardner MP, Tarazi FI, Baldessarini RJ, Neumeyer JL. Synthesis and dopamine receptor affinities of N-alkyl-11-hydroxy-2-methoxynoraporphines: N-alkyl substituents determine D1 versus D2 receptor selectivity. J Med Chem. 2008 Feb 28; 51(4):983-7. PMID: 18251489.
    Citations: 4     Fields:    Translation:AnimalsCells
  29. Reindl JD, Rowan K, Carey AN, Peng X, Neumeyer JL, McLaughlin JP. Antidepressant-like effects of the novel kappa opioid antagonist MCL-144B in the forced-swim test. Pharmacology. 2008; 81(3):229-35. PMID: 18176093.
    Citations: 15     Fields:    Translation:Animals
  30. Desai RI, Neumeyer JL, Bergman J, Paronis CA. Pharmacological characterization of the effects of dopamine D(1) agonists on eye blinking in rats. Behav Pharmacol. 2007 Dec; 18(8):745-54. PMID: 17989512.
    Citations: 2     Fields:    Translation:Animals
  31. Si YG, Gardner MP, Tarazi FI, Baldessarini RJ, Neumeyer JL. R-(-)-N-alkyl-11-hydroxy-10-hydroxymethyl- and 10-methyl-aporphines as 5-HT1A receptor ligands. Bioorg Med Chem Lett. 2007 Aug 01; 17(15):4128-30. PMID: 17543523.
    Citations: 3     Fields:    Translation:AnimalsCells
  32. Zhang A, Li F, Ding C, Yao Q, Knapp BI, Bidlack JM, Neumeyer JL. Synthesis and pharmacological evaluation of 6,7-indolo/thiazolo-morphinans--further SAR of levorphanol. J Med Chem. 2007 May 31; 50(11):2747-51. PMID: 17488103.
    Citations: 5     Fields:    Translation:AnimalsCells
  33. Wuest F, Berndt M, Strobel K, van den Hoff J, Peng X, Neumeyer JL, Bergmann R. Synthesis and radiopharmacological characterization of 2beta-carbo-2'-[18F]fluoroethoxy-3beta-(4-bromo-phenyl)tropane ([18F]MCL-322) as a PET radiotracer for imaging the dopamine transporter (DAT). Bioorg Med Chem. 2007 Jul 01; 15(13):4511-9. PMID: 17467995.
    Citations: 2     Fields:    Translation:AnimalsCells
  34. Peng X, Knapp BI, Bidlack JM, Neumeyer JL. Pharmacological properties of bivalent ligands containing butorphan linked to nalbuphine, naltrexone, and naloxone at mu, delta, and kappa opioid receptors. J Med Chem. 2007 May 03; 50(9):2254-8. PMID: 17407276.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  35. Peng X, Knapp BI, Bidlack JM, Neumeyer JL. In-vitro investigation of oxazol and urea analogues of morphinan at opioid receptors. Bioorg Med Chem. 2007 Jun 15; 15(12):4106-12. PMID: 17433695.
    Citations: 4     Fields:    Translation:AnimalsCells
  36. Zhang A, Zhang Y, Branfman AR, Baldessarini RJ, Neumeyer JL. Advances in development of dopaminergic aporphinoids. J Med Chem. 2007 Jan 25; 50(2):171-81. PMID: 17228858.
    Citations: 17     Fields:    Translation:HumansAnimals
  37. Peng X, Knapp BI, Bidlack JM, Neumeyer JL. High-affinity carbamate analogues of morphinan at opioid receptors. Bioorg Med Chem Lett. 2007 Mar 15; 17(6):1508-11. PMID: 17276685.
    Citations: 4     Fields:    Translation:AnimalsCells
  38. Zhang A, Neumeyer JL, Baldessarini RJ. Recent progress in development of dopamine receptor subtype-selective agents: potential therapeutics for neurological and psychiatric disorders. Chem Rev. 2007 Jan; 107(1):274-302. PMID: 17212477.
    Citations: 25     Fields:    Translation:HumansCells
  39. Peng X, Neumeyer JL. Kappa receptor bivalent ligands. Curr Top Med Chem. 2007; 7(4):363-73. PMID: 17305578.
    Citations: 6     Fields:    Translation:Cells
  40. Desai RI, Neumeyer JL, Paronis CA, Nguyen P, Bergman J. Behavioral effects of the R-(+)- and S-(-)-enantiomers of the dopamine D(1)-like partial receptor agonist SKF 83959 in monkeys. Eur J Pharmacol. 2007 Mar 08; 558(1-3):98-106. PMID: 17207791.
    Citations: 2     Fields:    Translation:Animals
  41. Neumeyer JL, Peng X, Knapp BI, Bidlack JM, Lazarus LH, Salvadori S, Trapella C, Balboni G. New opioid designed multiple ligand from Dmt-Tic and morphinan pharmacophores. J Med Chem. 2006 Sep 07; 49(18):5640-3. PMID: 16942040.
    Citations: 11     Fields:    Translation:AnimalsCells
  42. Peng X, Knapp BI, Bidlack JM, Neumeyer JL. Synthesis and preliminary in vitro investigation of bivalent ligands containing homo- and heterodimeric pharmacophores at mu, delta, and kappa opioid receptors. J Med Chem. 2006 Jan 12; 49(1):256-62. PMID: 16392810.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  43. Tóth M, Berényi S, Csutorás C, Kula NS, Zhang K, Baldessarini RJ, Neumeyer JL. Synthesis and dopamine receptor binding of sulfur-containing aporphines. Bioorg Med Chem. 2006 Mar 15; 14(6):1918-23. PMID: 16290940.
    Citations: 2     Fields:    Translation:AnimalsCells
  44. Mathews JL, Peng X, Xiong W, Zhang A, Negus SS, Neumeyer JL, Bidlack JM. Characterization of a novel bivalent morphinan possessing kappa agonist and micro agonist/antagonist properties. J Pharmacol Exp Ther. 2005 Nov; 315(2):821-7. PMID: 16076937.
    Citations: 9     Fields:    Translation:AnimalsCells
  45. Zhang A, Csutoras C, Zong R, Neumeyer JL. Synthesis of 2-fluoro-11-hydroxy-N-propylnoraporphine: a potential dopamine D2 agonist. Org Lett. 2005 Jul 21; 7(15):3239-42. PMID: 16018630.
    Citations: 2     Fields:    Translation:Animals
  46. Finnema SJ, Seneca N, Farde L, Shchukin E, Sóvágó J, Gulyás B, Wikström HV, Innis RB, Neumeyer JL, Halldin C. A preliminary PET evaluation of the new dopamine D2 receptor agonist [11C]MNPA in cynomolgus monkey. Nucl Med Biol. 2005 May; 32(4):353-60. PMID: 15878504.
    Citations: 19     Fields:    Translation:Animals
  47. Peng X, Zhang A, Kula NS, Baldessarini RJ, Neumeyer JL. Synthesis and amine transporter affinities of novel phenyltropane derivatives as potential positron emission tomography (PET) imaging agents. Bioorg Med Chem Lett. 2004 Nov 15; 14(22):5635-9. PMID: 15482938.
    Citations: 1     Fields:    Translation:AnimalsCells
  48. Csutoras C, Zhang A, Zhang K, Kula NS, Baldessarini RJ, Neumeyer JL. Synthesis and neuropharmacological evaluation of R(-)-N-alkyl-11-hydroxynoraporphines and their esters. Bioorg Med Chem. 2004 Jul 01; 12(13):3553-9. PMID: 15186839.
    Citations: 2     Fields:    Translation:AnimalsCells
  49. Csutoras C, Zhang A, Bidlack JM, Neumeyer JL. An investigation of the N-demethylation of 3-deoxymorphine and the affinity of the alkylation products to mu, delta, and kappa receptors. Bioorg Med Chem. 2004 May 15; 12(10):2687-90. PMID: 15110850.
    Citations: 2     Fields:    Translation:AnimalsCells
  50. Zhang A, Xiong W, Hilbert JE, DeVita EK, Bidlack JM, Neumeyer JL. 2-aminothiazole-derived opioids. Bioisosteric replacement of phenols. J Med Chem. 2004 Apr 08; 47(8):1886-8. PMID: 15055988.
    Citations: 13     Fields:    Translation:AnimalsCells
  51. Chaly T, Baldwin RM, Neumeyer JL, Hellman MJ, Dhawan V, Garg PK, Tamagnan G, Staley JK, Al-Tikriti MS, Hou Y, Zoghbi SS, Gu XH, Zong R, Eidelberg D. Radiosynthesis of [18F] N-(3-Fluoropropyl)-2-beta-Carbomethoxy-3-beta-(4-Bromophenyl) Nortropane and the regional brain uptake in non human primate using PET. Nucl Med Biol. 2004 Jan; 31(1):125-31. PMID: 14741577.
    Citations:    Fields:    Translation:Animals
  52. Zhang A, Xiong W, Bidlack JM, Hilbert JE, Knapp BI, Wentland MP, Neumeyer JL. 10-Ketomorphinan and 3-substituted-3-desoxymorphinan analogues as mixed kappa and micro opioid ligands: synthesis and biological evaluation of their binding affinity at opioid receptors. J Med Chem. 2004 Jan 01; 47(1):165-74. PMID: 14695830.
    Citations: 9     Fields:    Translation:AnimalsCells
  53. Neumeyer JL, Zhang A, Xiong W, Gu XH, Hilbert JE, Knapp BI, Negus SS, Mello NK, Bidlack JM. Design and synthesis of novel dimeric morphinan ligands for kappa and micro opioid receptors. J Med Chem. 2003 Nov 20; 46(24):5162-70. PMID: 14613319.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  54. Neumeyer JL, Kula NS, Bergman J, Baldessarini RJ. Receptor affinities of dopamine D1 receptor-selective novel phenylbenzazepines. Eur J Pharmacol. 2003 Aug 08; 474(2-3):137-40. PMID: 12921854.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  55. Bowen CA, Negus SS, Zong R, Neumeyer JL, Bidlack JM, Mello NK. Effects of mixed-action kappa/mu opioids on cocaine self-administration and cocaine discrimination by rhesus monkeys. Neuropsychopharmacology. 2003 Jun; 28(6):1125-39. PMID: 12637953.
    Citations: 28     Fields:    Translation:Animals
  56. Zhang A, Neumeyer JL. Microwave-promoted Pd-catalyzed cyanation of aryl triflates: a fast and versatile access to 3-cyano-3-desoxy-10-ketomorphinans. Org Lett. 2003 Jan 23; 5(2):201-3. PMID: 12529140.
    Citations: 4     Fields:    Translation:Cells
  57. Gu XH, Zong R, Kula NS, Baldessarini RJ, Neumeyer JL. Synthesis and biological evaluation of a series of novel N- or O-fluoroalkyl derivatives of tropane: potential positron emission tomography (PET) imaging agents for the dopamine transporter. Bioorg Med Chem Lett. 2001 Dec 03; 11(23):3049-53. PMID: 11714608.
    Citations: 3     Fields:    Translation:AnimalsCells
  58. Neumeyer JL, Gu XH, van Vliet LA, DeNunzio NJ, Rusovici DE, Cohen DJ, Negus SS, Mello NK, Bidlack JM. Mixed kappa agonists and mu agonists/antagonists as potential pharmacotherapeutics for cocaine abuse: synthesis and opioid receptor binding affinity of N-substituted derivatives of morphinan. Bioorg Med Chem Lett. 2001 Oct 22; 11(20):2735-40. PMID: 11591513.
    Citations: 9     Fields:    Translation:Humans
  59. Neumeyer JL, Mello NK, Negus SS, Bidlack JM. Kappa opioid agonists as targets for pharmacotherapies in cocaine abuse. Pharm Acta Helv. 2000 Mar; 74(2-3):337-44. PMID: 10812979.
    Citations: 10     Fields:    Translation:Animals
  60. Neumeyer JL, Bidlack JM, Zong R, Bakthavachalam V, Gao P, Cohen DJ, Negus SS, Mello NK. Synthesis and opioid receptor affinity of morphinan and benzomorphan derivatives: mixed kappa agonists and mu agonists/antagonists as potential pharmacotherapeutics for cocaine dependence. J Med Chem. 2000 Jan 13; 43(1):114-22. PMID: 10633042.
    Citations: 14     Fields:    Translation:Animals
  61. Scanley BE, Gandelman MS, Laruelle M, Al-Tikriti MS, Baldwin RM, Zoghbi SS, Hoffer PB, Wang S, Neumeyer JL, Innis RB. [123I]IPCIT and [123I]beta-CIT as SPECT tracers for the dopamine transporter: a comparative analysis in nonhuman primates. Nucl Med Biol. 2000 Jan; 27(1):13-21. PMID: 10755641.
    Citations:    Fields:    Translation:HumansAnimals
  62. Kula NS, Baldessarini RJ, Tarazi FI, Fisser R, Wang S, Trometer J, Neumeyer JL. [3H]beta-CIT: a radioligand for dopamine transporters in rat brain tissue. Eur J Pharmacol. 1999 Dec 03; 385(2-3):291-4. PMID: 10607889.
    Citations: 6     Fields:    Translation:AnimalsCells
  63. Zhang K, Tarazi FI, Kula NS, Baldessarini RJ, Neumeyer JL. Selective alkylatation of dopamine D2 and D4 receptors in rat brain by N-(p-isothiocyanatophenethyl)spiperone. Neurosci Lett. 1999 Oct 29; 274(3):155-8. PMID: 10548413.
    Citations:    Fields:    Translation:AnimalsCells
  64. Tamagnan G, Gao Y, Xu L, Kula NS, Baldessarini RJ, Neumeyer JL. Nonisotopic surrogates for technetium as ligands for monoamine transporters. Adv Neurol. 1999; 80:99-103. PMID: 10410707.
    Citations:    Fields:    Translation:Animals
  65. Kazumata K, Dhawan V, Chaly T, Antonini A, Margouleff C, Belakhlef A, Neumeyer J, Eidelberg D. Dopamine transporter imaging with fluorine-18-FPCIT and PET. J Nucl Med. 1998 Sep; 39(9):1521-30. PMID: 9744335.
    Citations: 33     Fields:    Translation:Humans
  66. Yeghiayan SK, Gongwer MA, Baldessarini RJ, Kula NS, Zong R, Neumeyer JL. Local injection of alkylating and nonalkylating dopamine receptor antagonists into rat basal forebrain: autoradiographic assessment of D2-like and D3 sites. Brain Res. 1998 May 11; 792(2):324-6. PMID: 9593972.
    Citations:    Fields:    Translation:Animals
  67. Tarazi FI, Yeghiayan SK, Neumeyer JL, Baldessarini RJ. Medial prefrontal cortical D2 and striatolimbic D4 dopamine receptors: common targets for typical and atypical antipsychotic drugs. Prog Neuropsychopharmacol Biol Psychiatry. 1998 May; 22(4):693-707. PMID: 9682281.
    Citations: 6     Fields:    Translation:Animals
  68. Abi-Dargham A, Innis RB, Wisniewski G, Baldwin RM, Neumeyer JL, Seibyl JP. Human biodistribution and dosimetry of iodine-123-fluoroalkyl analogs of beta-CIT. Eur J Nucl Med. 1997 Nov; 24(11):1422-5. PMID: 9371877.
    Citations: 1     Fields:    Translation:HumansCellsCTClinical Trials
  69. Tarazi FI, Yeghiayan SK, Baldessarini RJ, Kula NS, Neumeyer JL. Long-term effects of S(+)N-n-propylnorapomorphine compared with typical and atypical antipsychotics: differential increases of cerebrocortical D2-like and striatolimbic D4-like dopamine receptors. Neuropsychopharmacology. 1997 Sep; 17(3):186-96. PMID: 9272485.
    Citations: 4     Fields:    Translation:AnimalsCells
  70. Oliver DW, Dormehl IC, Van der Schyf CJ, Neumeyer JL, Hugo N, Keeve R, Rossouw NT, Müller-Gärtner HW, Castagnoli N. Effect of the haloperidol tetrahydropyridine metabolite 4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]-1,2,3,6- tetrahydropyridine on dopamine receptor and transporter binding. A nonhuman primate 123I-iodobenzamide and 2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane single photon emission computed tomographic study. Arzneimittelforschung. 1997 Jun; 47(6):692-9. PMID: 9239444.
    Citations:    Fields:    Translation:Animals
  71. Chaly T, Dhawan V, Kazumata K, Antonini A, Margouleff C, Dahl JR, Belakhlef A, Margouleff D, Yee A, Wang S, Tamagnan G, Neumeyer JL, Eidelberg D. Radiosynthesis of [18F] N-3-fluoropropyl-2-beta-carbomethoxy-3-beta-(4-iodophenyl) nortropane and the first human study with positron emission tomography. Nucl Med Biol. 1996 Nov; 23(8):999-1004. PMID: 9004288.
    Citations: 7     Fields:    Translation:Humans
  72. Ishikawa T, Dhawan V, Kazumata K, Chaly T, Mandel F, Neumeyer J, Margouleff C, Babchyck B, Zanzi I, Eidelberg D. Comparative nigrostriatal dopaminergic imaging with iodine-123-beta CIT-FP/SPECT and fluorine-18-FDOPA/PET. J Nucl Med. 1996 Nov; 37(11):1760-5. PMID: 8917170.
    Citations: 25     Fields:    Translation:Humans
  73. Abi-Dargham A, Gandelman MS, DeErausquin GA, Zea-Ponce Y, Zoghbi SS, Baldwin RM, Laruelle M, Charney DS, Hoffer PB, Neumeyer JL, Innis RB. SPECT imaging of dopamine transporters in human brain with iodine-123-fluoroalkyl analogs of beta-CIT. J Nucl Med. 1996 Jul; 37(7):1129-33. PMID: 8965183.
    Citations: 11     Fields:    Translation:Humans
  74. Mak CK, Avalos M, Randall PK, Kwan SW, Abell CW, Neumeyer JL, Whisennand R, Wilcox RE. Improved models for pharmacological null experiments: calculation of drug efficacy at recombinant D1A dopamine receptors stably expressed in clonal cell lines. Neuropharmacology. 1996 May; 35(5):549-70. PMID: 8887963.
    Citations: 1     Fields:    Translation:AnimalsCells
  75. Seibyl JP, Laruelle M, van Dyck CH, Wallace E, Baldwin RM, Zoghbi S, Zea-Ponce Y, Neumeyer JL, Charney DS, Hoffer PB, Innis RB. Reproducibility of iodine-123-beta-CIT SPECT brain measurement of dopamine transporters. J Nucl Med. 1996 Feb; 37(2):222-8. PMID: 8667048.
    Citations: 11     Fields:    Translation:Humans
  76. Neumeyer JL, Tamagnan G, Wang S, Gao Y, Milius RA, Kula NS, Baldessarini RJ. N-substituted analogs of 2 beta-carbomethoxy-3 beta- (4'-iodophenyl)tropane (beta-CIT) with selective affinity to dopamine or serotonin transporters in rat forebrain. J Med Chem. 1996 Jan 19; 39(2):543-8. PMID: 8558525.
    Citations: 8     Fields:    Translation:AnimalsCells
  77. Lanier B, Raddatz R, Bakthavachalam V, Coupry I, Neumeyer JL, Lanier SM. Structural and ligand recognition properties of imidazoline binding proteins in tissues of rat and rabbit. Mol Pharmacol. 1995 Oct; 48(4):703-10. PMID: 7476897.
    Citations: 2     Fields:    Translation:AnimalsCells
  78. Lundkvist C, Halldin C, Swahn CG, Hall H, Karlsson P, Nakashima Y, Wang S, Milius RA, Neumeyer JL, Farde L. [O-methyl-11C]beta-CIT-FP, a potential radioligand for quantitation of the dopamine transporter: preparation, autoradiography, metabolite studies, and positron emission tomography examinations. Nucl Med Biol. 1995 Oct; 22(7):905-13. PMID: 8547888.
    Citations: 3     Fields:    Translation:HumansAnimals
  79. Lanier SM, Lanier B, Bakthavachalam V, McGrath CR, Neumeyer JL. Use of high affinity, radioiodinated probes for identification of imidazoline/guanidinium receptive sites. Ann N Y Acad Sci. 1995 Jul 12; 763:106-11. PMID: 7677319.
    Citations: 2     Fields:    Translation:Animals
  80. Kuikka JT, Akerman K, Bergström KA, Karhu J, Hiltunen J, Haukka J, Heikkinen J, Tiihonen J, Wang S, Neumeyer JL. Iodine-123 labelled N-(2-fluoroethyl)-2 beta-carbomethoxy-3 beta-(4-iodophenyl)nortropane for dopamine transporter imaging in the living human brain. Eur J Nucl Med. 1995 Jul; 22(7):682-6. PMID: 7498231.
    Citations: 2     Fields:    Translation:HumansCTClinical Trials
  81. Kuikka JT, Bergström KA, Ahonen A, Hiltunen J, Haukka J, Länsimies E, Wang S, Neumeyer JL. Comparison of iodine-123 labelled 2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane and 2 beta-carbomethoxy-3 beta-(4-iodophenyl)-N-(3-fluoropropyl)nortropane for imaging of the dopamine transporter in the living human brain. Eur J Nucl Med. 1995 Apr; 22(4):356-60. PMID: 7607268.
    Citations: 5     Fields:    Translation:Humans
  82. Zea-Ponce Y, Baldwin RM, Laruelle M, Wang S, Neumeyer JL, Innis RB. Simplified multidose preparation of iodine-123-beta-CIT: a marker for dopamine transporters. J Nucl Med. 1995 Mar; 36(3):525-9. PMID: 7884521.
    Citations: 2     Fields:    Translation:HumansCells
  83. Baldwin RM, Zea-Ponce Y, al-Tikriti MS, Zoghbi SS, Seibyl JP, Charney DS, Hoffer PB, Wang S, Milius RA, Neumeyer JL, et al. Regional brain uptake and pharmacokinetics of [123I]N-omega-fluoroalkyl-2 beta-carboxy-3 beta-(4-iodophenyl)nortropane esters in baboons. Nucl Med Biol. 1995 Feb; 22(2):211-9. PMID: 7767315.
    Citations: 4     Fields:    Translation:AnimalsCells
  84. Laruelle M, Wallace E, Seibyl JP, Baldwin RM, Zea-Ponce Y, Zoghbi SS, Neumeyer JL, Charney DS, Hoffer PB, Innis RB. Graphical, kinetic, and equilibrium analyses of in vivo [123I] beta-CIT binding to dopamine transporters in healthy human subjects. J Cereb Blood Flow Metab. 1994 Nov; 14(6):982-94. PMID: 7929662.
    Citations: 32     Fields:    Translation:Humans
  85. Baldessarini RJ, Campbell A, Ben-Jonathan N, Ellingboe J, Zong R, Neumeyer JL. Effects of aporphine isomers on rat prolactin. Neurosci Lett. 1994 Aug 01; 176(2):269-71. PMID: 7830962.
    Citations:    Fields:    Translation:Animals
  86. Ivkovic B, Bakthavachalam V, Zhang W, Parini A, Diz D, Bosch S, Neumeyer JL, Lanier SM. Development of a high-affinity radioiodinated ligand for identification of imidazoline/guanidinium receptive sites (IGRS): intratissue distribution of IGRS in liver, forebrain, and kidney. Mol Pharmacol. 1994 Jul; 46(1):15-23. PMID: 8058049.
    Citations:    Fields:    Translation:AnimalsCells
  87. Neumeyer JL, Wang S, Gao Y, Milius RA, Kula NS, Campbell A, Baldessarini RJ, Zea-Ponce Y, Baldwin RM, Innis RB. N-omega-fluoroalkyl analogs of (1R)-2 beta-carbomethoxy-3 beta-(4-iodophenyl)-tropane (beta-CIT): radiotracers for positron emission tomography and single photon emission computed tomography imaging of dopamine transporters. J Med Chem. 1994 May 27; 37(11):1558-61. PMID: 8201589.
    Citations: 14     Fields:    Translation:AnimalsCells
  88. Seibyl JP, Wallace E, Smith EO, Stabin M, Baldwin RM, Zoghbi S, Zea-Ponce Y, Gao Y, Zhang WY, Neumeyer JL, et al. Whole-body biodistribution, radiation absorbed dose and brain SPECT imaging with iodine-123-beta-CIT in healthy human subjects. J Nucl Med. 1994 May; 35(5):764-70. PMID: 8176456.
    Citations: 7     Fields:    Translation:Humans
  89. Kula NS, Baldessarini RJ, Kebabian JW, Neumeyer JL. S-(+)-aporphines are not selective for human D3 dopamine receptors. Cell Mol Neurobiol. 1994 Apr; 14(2):185-91. PMID: 7842476.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  90. Baldessarini RJ, Kula NS, Zong R, Neumeyer JL. Receptor affinities of aporphine enantiomers in rat brain tissue. Eur J Pharmacol. 1994 Mar 11; 254(1-2):199-203. PMID: 7911429.
    Citations:    Fields:    Translation:Animals
  91. Laruelle M, Giddings SS, Zea-Ponce Y, Charney DS, Neumeyer JL, Baldwin RM, Innis RB. Methyl 3 beta-(4-[125I]iodophenyl)tropane-2 beta-carboxylate in vitro binding to dopamine and serotonin transporters under "physiological" conditions. J Neurochem. 1994 Mar; 62(3):978-86. PMID: 8113817.
    Citations: 7     Fields:    Translation:AnimalsCells
  92. Hashimoto K, Mantione CR, Spada MR, Neumeyer JL, London ED. Further characterization of [3H]ifenprodil binding in rat brain. Eur J Pharmacol. 1994 Jan 01; 266(1):67-77. PMID: 7907988.
    Citations: 9     Fields:    Translation:AnimalsCells
  93. Jacobson KA, Shi D, Gallo-Rodriguez C, Manning M, Müller C, Daly JW, Neumeyer JL, Kiriasis L, Pfleiderer W. Effect of trifluoromethyl and other substituents on activity of xanthines at adenosine receptors. J Med Chem. 1993 Sep 03; 36(18):2639-44. PMID: 8410976.
    Citations: 5     Fields:    Translation:AnimalsCells
  94. Baldessarini RJ, Kula NS, McGrath CR, Bakthavachalam V, Kebabian JW, Neumeyer JL. Isomeric selectivity at dopamine D3 receptors. Eur J Pharmacol. 1993 Aug 03; 239(1-3):269-70. PMID: 8223909.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  95. Lanier SM, Ivkovic B, Singh I, Neumeyer JL, Bakthavachalam V. Visualization of multiple imidazoline/guanidinium-receptive sites. J Biol Chem. 1993 Jul 25; 268(21):16047-51. PMID: 8340426.
    Citations: 3     Fields:    Translation:AnimalsCells
  96. Baldwin RM, Zea-Ponce Y, Zoghbi SS, Laurelle M, al-Tikriti MS, Sybirska EH, Malison RT, Neumeyer JL, Milius RA, Wang S, et al. Evaluation of the monoamine uptake site ligand [123I]methyl 3 beta-(4-iodophenyl)-tropane-2 beta-carboxylate ([123I]beta-CIT) in non-human primates: pharmacokinetics, biodistribution and SPECT brain imaging coregistered with MRI. Nucl Med Biol. 1993 Jul; 20(5):597-606. PMID: 8358345.
    Citations: 11     Fields:    Translation:Animals
  97. Wang S, Gao Y, Laruelle M, Baldwin RM, Scanley BE, Innis RB, Neumeyer JL. Enantioselectivity of cocaine recognition sites: binding of (1S)- and (1R)-2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane (beta-CIT) to monoamine transporters. J Med Chem. 1993 Jun 25; 36(13):1914-7. PMID: 8515428.
    Citations: 1     Fields:    Translation:AnimalsCells
  98. Müller L, Halldin C, Farde L, Karlsson P, Hall H, Swahn CG, Neumeyer J, Gao Y, Milius R. [11C] beta-CIT, a cocaine analogue. Preparation, autoradiography and preliminary PET investigations. Nucl Med Biol. 1993 Apr; 20(3):249-55. PMID: 8485483.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  99. Laruelle M, Baldwin RM, Malison RT, Zea-Ponce Y, Zoghbi SS, al-Tikriti MS, Sybirska EH, Zimmermann RC, Wisniewski G, Neumeyer JL, et al. SPECT imaging of dopamine and serotonin transporters with [123I]beta-CIT: pharmacological characterization of brain uptake in nonhuman primates. Synapse. 1993 Apr; 13(4):295-309. PMID: 7683143.
    Citations: 51     Fields:    Translation:Animals
  100. Campbell A, Baldessarini RJ, Neumeyer JL. Altered spontaneous behavior and sensitivity to apomorphine in rats following pretreatment with S(+)-aporphines or fluphenazine. Psychopharmacology (Berl). 1993; 111(3):351-8. PMID: 7870974.
    Citations: 2     Fields:    Translation:Animals
  101. Baldessarini RJ, Kula NS, Campbell A, Bakthavachalam V, Yuan J, Neumeyer JL. Prolonged D2 antidopaminergic activity of alkylating and nonalkylating derivatives of spiperone in rat brain. Mol Pharmacol. 1992 Nov; 42(5):856-63. PMID: 1435753.
    Citations: 2     Fields:    Translation:Animals
  102. Neumeyer JL, Kula NS, Baldessarini RJ, Baindur N. Stereoisomeric probes for the D1 dopamine receptor: synthesis and characterization of R-(+) and S-(-) enantiomers of 3-allyl-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine and its 6-bromo analogue. J Med Chem. 1992 Apr 17; 35(8):1466-71. PMID: 1533424.
    Citations: 2     Fields:    Translation:Animals
  103. Neumeyer JL, Baindur N, Bakthavachalam V, Yuan J, Madras BK, Kula NS, Campbell A, Baldessarini RJ. Alan Horn Memorial Lecture. Selective probes for characterization of dopamine D1 and D2 receptors. Neurochem Int. 1992 Mar; 20 Suppl:63S-68S. PMID: 1365458.
    Citations:    Fields:    Translation:HumansAnimals
  104. Baindur N, Tran M, Niznik HB, Guan HC, Seeman P, Neumeyer JL. (+/-)-3-allyl-7-halo-8-hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines as selective high affinity D1 dopamine receptor antagonists: synthesis and structure-activity relationship. J Med Chem. 1992 Jan; 35(1):67-72. PMID: 1531075.
    Citations: 2     Fields:    Translation:Animals
  105. Neumeyer JL, Baindur N, Niznik HB, Guan HC, Seeman P. (+/-)-3-Allyl-6-bromo-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3- benzazepin, a new high-affinity D1 dopamine receptor ligand: synthesis and structure-activity relationship. J Med Chem. 1991 Dec; 34(12):3366-71. PMID: 1684995.
    Citations: 2     Fields:    Translation:AnimalsCells
  106. Bakthavachalam V, Baindur N, Madras BK, Neumeyer JL. Fluorescent probes for dopamine receptors: synthesis and characterization of fluorescein and 7-nitrobenz-2-oxa-1,3-diazol-4-yl conjugates of D-1 and D-2 receptor ligands. J Med Chem. 1991 Nov; 34(11):3235-41. PMID: 1956042.
    Citations: 4     Fields:    Translation:Animals
  107. Neumeyer JL, Wang SY, Milius RA, Baldwin RM, Zea-Ponce Y, Hoffer PB, Sybirska E, al-Tikriti M, Charney DS, Malison RT, et al. [123I]-2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane: high-affinity SPECT radiotracer of monoamine reuptake sites in brain. J Med Chem. 1991 Oct; 34(10):3144-6. PMID: 1920365.
    Citations: 23     Fields:    Translation:Animals
  108. Milius RA, Saha JK, Madras BK, Neumeyer JL. Synthesis and receptor binding of N-substituted tropane derivatives. High-affinity ligands for the cocaine receptor. J Med Chem. 1991 May; 34(5):1728-31. PMID: 2033595.
    Citations:    Fields:    Translation:AnimalsCells
  109. Baldessarini RJ, Kula NS, Gao Y, Campbell A, Neumeyer JL. R(-)2-fluoro-N-n-propylnorapomorphine: a very potent and D2-selective dopamine agonist. Neuropharmacology. 1991 Jan; 30(1):97-9. PMID: 1675452.
    Citations: 1     Fields:    Translation:AnimalsCells
  110. Campbell A, Yeghiayan S, Baldessarini RJ, Neumeyer JL. Selective antidopaminergic effects of S(+)N-n-propylnoraporphines in limbic versus extrapyramidal sites in rat brain: comparisons with typical and atypical antipsychotic agents. Psychopharmacology (Berl). 1991; 103(3):323-9. PMID: 1676180.
    Citations: 2     Fields:    Translation:Animals
  111. Neumeyer JL, Gao YG, Kula NS, Baldessarini RJ. R and S enantiomers of 11-hydroxy- and 10,11-dihydroxy-N-allylnoraporphine: synthesis and affinity for dopamine receptors in rat brain tissue. J Med Chem. 1991 Jan; 34(1):24-8. PMID: 1671415.
    Citations: 1     Fields:    Translation:AnimalsCells
  112. Neumeyer JL, Gao YG, Kula NS, Baldessarini RJ. Synthesis and dopamine receptor affinity of (R)-(-)-2-fluoro-N-n-propylnorapomorphine: a highly potent and selective dopamine D2 agonist. J Med Chem. 1990 Dec; 33(12):3122-4. PMID: 2147956.
    Citations: 5     Fields:    Translation:AnimalsCells
  113. Baldessarini RJ, Marsh ER, Kula NS, Zong RS, Gao YG, Neumeyer JL. Effects of isomers of hydroxyaporphines on dopamine metabolism in rat brain regions. Biochem Pharmacol. 1990 Aug 01; 40(3):417-23. PMID: 2383279.
    Citations: 2     Fields:    Translation:Animals
  114. Booth RG, Baldessarini RJ, Kula NS, Gao Y, Zong R, Neumeyer JL. Presynaptic inhibition of dopamine synthesis in rat striatal tissue by enantiomeric mono- and dihydroxyaporphines. Mol Pharmacol. 1990 Jul; 38(1):92-101. PMID: 1973525.
    Citations: 3     Fields:    Translation:Animals
  115. Madras BK, Canfield DR, Pfaelzer C, Vittimberga FJ, Difiglia M, Aronin N, Bakthavachalam V, Baindur N, Neumeyer JL. Fluorescent and biotin probes for dopamine receptors: D1 and D2 receptor affinity and selectivity. Mol Pharmacol. 1990 Jun; 37(6):833-9. PMID: 2141665.
    Citations: 5     Fields:    Translation:Animals
  116. Campbell A, Baldessarini RJ, Gao Y, Zong R, Neumeyer JL. R(-) and S(+) stereoisomers of 11-hydroxy- and 11-methoxy-N-n-propylnoraporphine: central dopaminergic behavioral activity in the rat. Neuropharmacology. 1990 Jun; 29(6):527-36. PMID: 1974710.
    Citations: 4     Fields:    Translation:Animals
  117. Gao YG, Baldessarini RJ, Kula NS, Neumeyer JL. Synthesis and dopamine receptor affinities of enantiomers of 2-substituted apomorphines and their N-n-propyl analogues. J Med Chem. 1990 Jun; 33(6):1800-5. PMID: 1971309.
    Citations: 12     Fields:    Translation:AnimalsCells
  118. Madras BK, Kamien JB, Fahey MA, Canfield DR, Milius RA, Saha JK, Neumeyer JL, Spealman RD. N-modified fluorophenyltropane analogs of cocaine with high affinity for cocaine receptors. Pharmacol Biochem Behav. 1990 Apr; 35(4):949-53. PMID: 2345768.
    Citations: 1     Fields:    Translation:Animals
  119. Neumeyer JL, Baindur N, Yuan J, Booth G, Seeman P, Niznik HB. Development of a high affinity and stereoselective photoaffinity label for the D-1 dopamine receptor: synthesis and resolution of 7-[125I]iodo-8-hydroxy-3-methyl-1-(4'-azidophenyl)-2,3,4,5-tetrahydro- 1H-3-benzazepine. J Med Chem. 1990 Feb; 33(2):521-6. PMID: 2405157.
    Citations: 1     Fields:    Translation:AnimalsCells
  120. Gao YG, Ram VJ, Campbell A, Kula NS, Baldessarini RJ, Neumeyer JL. Synthesis and structural requirements of N-substituted norapomorphines for affinity and activity at dopamine D-1, D-2, and agonist receptor sites in rat brain. J Med Chem. 1990 Jan; 33(1):39-44. PMID: 2136919.
    Citations: 1     Fields:    Translation:AnimalsCells
  121. Madras BK, Spealman RD, Fahey MA, Neumeyer JL, Saha JK, Milius RA. Cocaine receptors labeled by [3H]2 beta-carbomethoxy-3 beta-(4-fluorophenyl)tropane. Mol Pharmacol. 1989 Oct; 36(4):518-24. PMID: 2811854.
    Citations: 31     Fields:    Translation:AnimalsCells
  122. Jacobson KA, Kiriasis L, Barone S, Bradbury BJ, Kammula U, Campagne JM, Secunda S, Daly JW, Neumeyer JL, Pfleiderer W. Sulfur-containing 1,3-dialkylxanthine derivatives as selective antagonists at A1-adenosine receptors. J Med Chem. 1989 Aug; 32(8):1873-9. PMID: 2754711.
    Citations: 6     Fields:    Translation:AnimalsCells
  123. Ramsby S, Neumeyer JL, Grigoriadis D, Seeman P. 2-Haloaporphines as potent dopamine agonists. J Med Chem. 1989 Jun; 32(6):1198-201. PMID: 2524592.
    Citations: 2     Fields:    Translation:AnimalsCells
  124. Trainor TM, Vouros P, Lampen P, Neumeyer JL, Baldessarini RJ, Kula NS. Determination of N-n-propylnorapomorphine in serum and brain tissue by gas chromatography-negative ion chemical ionization mass spectrometry. J Chromatogr. 1988 Dec 21; 457:257-66. PMID: 3243885.
    Citations:    Fields:    Translation:Animals
  125. Baindur N, Neumeyer JL, Niznik HB, Bzowej NH, Jarvie KR, Seeman P, Garlick RK, Miller JJ. A photoaffinity label for the D-1 dopamine receptor, (RS)-7-[125I]Iodo-8-hydroxy-3-methyl-1-(4'-azidophenyl)-2,3,4,5- tetrahydro-1H-3-benzazepine, selectively identifies the ligand binding subunits of the receptor. J Med Chem. 1988 Nov; 31(11):2069-71. PMID: 3263503.
    Citations:    Fields:    Translation:AnimalsCells
  126. Niznik HB, Jarvie KR, Bzowej NH, Seeman P, Garlick RK, Miller JJ, Baindur N, Neumeyer JL. Photoaffinity labeling of dopamine D1 receptors. Biochemistry. 1988 Oct 04; 27(20):7594-9. PMID: 3207691.
    Citations: 8     Fields:    Translation:AnimalsCells
  127. Jacobson KA, de la Cruz R, Schulick R, Kiriasis L, Padgett W, Pfleiderer W, Kirk KL, Neumeyer JL, Daly JW. 8-Substituted xanthines as antagonists at A1- and A2-adenosine receptors. Biochem Pharmacol. 1988 Oct 01; 37(19):3653-61. PMID: 3178879.
    Citations: 12     Fields:    Translation:Animals
  128. Cox RF, Neumeyer JL, Waszczak BL. Effects of N-n-propylnorapomorphine enantiomers on single unit activity of substantia nigra pars compacta and ventral tegmental area dopamine neurons. J Pharmacol Exp Ther. 1988 Oct; 247(1):355-62. PMID: 3171980.
    Citations: 3     Fields:    Translation:Animals
  129. Neumeyer JL, Schultes RE, Musto JD, Woodland L. Evaluation of chemical tests on vouchered specimens of Cannabis. J Psychoactive Drugs. 1988 Oct-Dec; 20(4):459-62. PMID: 2854156.
    Citations:    Fields:    Translation:Animals
  130. Gao Y, Zong R, Campbell A, Kula NS, Baldessarini RJ, Neumeyer JL. Synthesis and dopamine agonist and antagonist effects of (R)-(-)- and (S)-(+)-11-hydroxy-N-n-propylnoraporphine. J Med Chem. 1988 Jul; 31(7):1392-6. PMID: 3385732.
    Citations: 3     Fields:    Translation:AnimalsCells
  131. Lampen P, Neumeyer JL, Baldessarini RJ. High-performance liquid chromatographic separation and electrochemical or spectrophotometric determination of R(-)N-n-propylnorapomorphine and R(-)10,11-methylenedioxy-N-n-propylnoraporphine in primate plasma. J Chromatogr. 1988 Apr 29; 426(2):283-94. PMID: 3392141.
    Citations:    Fields:    Translation:Animals
  132. Kula NS, Baldessarini RJ, Murphy F, Neumeyer JL. Substituted phenylpiperidines and phenylpyridines as reversible selective inhibitors of monoamine oxidase type A in rodent brain and liver. Biochem Pharmacol. 1988 Feb 15; 37(4):763-6. PMID: 3257699.
    Citations:    Fields:    Translation:Animals
  133. Neumeyer JL, Froimowitz M, Baldessarini RJ, Campbell A, Gao YG. Neuropharmacology and stereochemistry of dopamine receptor agonist and antagonist enantiomeric pairs. J Recept Res. 1988; 8(1-4):83-96. PMID: 3385694.
    Citations: 1     Fields:    Translation:Cells
  134. Campbell A, Baldessarini RJ, Kula NS, Ram VJ, Neumeyer JL. S(+)methylenedioxy-N-n-propylnoraporphine: an orally active inhibitor of dopamine selective for rat limbic system. Brain Res. 1987 Feb 17; 403(2):393-7. PMID: 3828830.
    Citations: 2     Fields:    Translation:Animals
  135. Baldessarini RJ, Kula NS, Francoeur D, Finklestein SP, Murphy F, Neumeyer JL. Synthetic analgesics and other phenylpiperidines: effects on uptake and storage of dopamine and other monoamines mouse forebrain tissue. Life Sci. 1986 Nov 10; 39(19):1765-77. PMID: 3490612.
    Citations:    Fields:    Translation:AnimalsCells
  136. Froimowitz M, Neumeyer JL, Baldessarini RJ. A stereochemical explanation of the dopamine agonist and antagonist activity of stereoisomeric pairs. J Med Chem. 1986 Sep; 29(9):1570-3. PMID: 3746808.
    Citations: 1     Fields:    Translation:Cells
  137. Neumeyer JL, Abdel-Maksoud HM, Trainor TM, Vouros P, Davis PJ. Aporphines 65: chemical, microbial synthesis and characterization by gas chromatography/mass spectrometry of (R)-(-)-10-hydroxy 11-methoxy-N-n-propylnoraporphine, a potential metabolite of N-n-propylnorapomorphine. Biomed Environ Mass Spectrom. 1986 May; 13(5):223-9. PMID: 2941089.
    Citations:    Fields:    Translation:Cells
  138. Baldessarini RJ, Neumeyer JL. Lack of depletion of striatal dopamine by phenylpiperidine analgesics. N Engl J Med. 1986 Mar 06; 314(10):649. PMID: 3484802.
    Citations:    Fields:    Translation:Animals
  139. Neumeyer JL, Szabo S. Evidence for the involvement of dopamine agonists and antagonists in duodenal ulcer disease. Klin Wochenschr. 1986; 64 Suppl 7:123-7. PMID: 3494157.
    Citations:    Fields:    Translation:Animals
  140. Campbell A, Baldessarini RJ, Teicher MH, Neumeyer JL. Behavioral effects of apomorphine isomers in the rat: selective locomotor-inhibitory effects of S(+)N-n-propylnorapomorphine. Psychopharmacology (Berl). 1986; 88(2):158-64. PMID: 3081927.
    Citations: 4     Fields:    Translation:Animals
  141. Szabo S, Brown A, Pihan G, Dali H, Neumeyer JL. Duodenal ulcer induced by MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine). Proc Soc Exp Biol Med. 1985 Dec; 180(3):567-71. PMID: 2417250.
    Citations: 10     Fields:    Translation:Animals
  142. Seeman P, Watanabe M, Grigoriadis D, Tedesco JL, George SR, Svensson U, Nilsson JL, Neumeyer JL. Dopamine D2 receptor binding sites for agonists. A tetrahedral model. Mol Pharmacol. 1985 Nov; 28(5):391-9. PMID: 2932631.
    Citations: 23     Fields:    Translation:AnimalsCells
  143. Kula NS, Baldessarini RJ, Bromley S, Neumeyer JL. Effects of isomers of apomorphines on dopamine receptors in striatal and limbic tissue of rat brain. Life Sci. 1985 Sep 16; 37(11):1051-7. PMID: 4033350.
    Citations:    Fields:    Translation:AnimalsCells
  144. Campbell A, Baldessarini RJ, Teicher MH, Neumeyer JL. S(+)Apomorphines. Selective inhibition of excitatory effects of dopamine injected into the limbic system of the rat. Neuropharmacology. 1985 May; 24(5):391-9. PMID: 4022264.
    Citations: 4     Fields:    Translation:Animals
  145. Niznik HB, Dumbrille-Ross A, Guan JH, Neumeyer JL, Seeman P. Dopamine D2 receptors photolabeled by iodo-azido-clebopride. Neurosci Lett. 1985 Apr 19; 55(3):267-72. PMID: 3159976.
    Citations: 1     Fields:    Translation:AnimalsCells
  146. Neumeyer JL, Guan JH, Niznik HB, Dumbrille-Ross A, Seeman P, Padmanabhan S, Elmaleh DR. Novel photoaffinity label for the dopamine D2 receptor: synthesis of 4-azido-5-iodo-2-methoxy-N-[1-(phenylmethyl)-4-piperidinyl] benzamide (iodoazidoclebopride, IAC) and the corresponding 125I-labeled analogue (125IAC). J Med Chem. 1985 Apr; 28(4):405-7. PMID: 3156993.
    Citations: 2     Fields:    Translation:AnimalsCells
  147. Davis PJ, Abdel-Maksoud H, Trainor TM, Vouros P, Neumeyer JL. Stereospecific microbiological 10-O-demethylation of R-(-)-10,11-dimethoxyaporphines. Biochem Biophys Res Commun. 1985 Mar 15; 127(2):407-12. PMID: 3838476.
    Citations: 1     Fields:    Translation:AnimalsCells
  148. Niznik HB, Guan JH, Neumeyer JL, Seeman P. A photoaffinity ligand for dopamine D2 receptors: azidoclebopride. Mol Pharmacol. 1985 Feb; 27(2):193-9. PMID: 3969068.
    Citations: 1     Fields:    Translation:AnimalsCells
  149. Hjorth S, Neumeyer JL. Central monoaminergic effects of two aporphine analogues to the putative serotonin-receptor agonist, 8-hydroxy-2-di-n-propylaminotetralin. Neuropharmacology. 1984 Oct; 23(10):1187-90. PMID: 6097834.
    Citations:    Fields:    Translation:AnimalsCells
  150. Niznik HB, Guan JH, Neumeyer JL, Seeman P. A dopamine D2 receptor photolabel: azidoclebopride. Eur J Pharmacol. 1984 Sep 17; 104(3-4):389-90. PMID: 6499931.
    Citations:    Fields:    Translation:AnimalsCells
  151. Arana GW, Lamont JS, Baldessarini RJ, Teicher MH, Neumeyer JL, Cohen BM. Binding of [3H]apomorphine to an aporphine binding site as well as to dopamine sites in tissue from bovine caudate nucleus. Neuropharmacology. 1984 Aug; 23(8):885-92. PMID: 6483116.
    Citations:    Fields:    Translation:AnimalsCells
  152. Kula NS, Baldessarini RJ, Campbell A, Finklestein S, Ram VJ, Neumeyer JL. Effects of N-substituted phenyltetrahydropyridines on cerebral high-affinity synaptosomal uptake of dopamine and other monoamines in several mammalian species. Life Sci. 1984 Jun 25; 34(26):2567-75. PMID: 6610812.
    Citations:    Fields:    Translation:HumansAnimalsCells
  153. Guan JH, Neumeyer JL, Filer CN, Ahern DG, Lilly L, Watanabe M, Grigoriadis D, Seeman P. Aporphines. 58. N-(2-chloroethyl) [8,9-2H]norapomorphine, an irreversible ligand for dopamine receptors: synthesis and application. J Med Chem. 1984 Jun; 27(6):806-10. PMID: 6737423.
    Citations:    Fields:    Translation:AnimalsCells
  154. Schmidt M, Imbs JL, Neumeyer JL, Giesen EM, Schwartz J. Vascular effects of apomorphine and related compounds in the perfused rat kidney. Eur J Pharmacol. 1984 Jan 13; 97(1-2):75-85. PMID: 6141949.
    Citations:    Fields:    Translation:Animals
  155. Arana GW, Baldessarini RJ, Lamont JS, Amlicke D, Neumeyer JL. Pharmacology of high-affinity binding of [3H](+/-)2-amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene (ADTN) to bovine caudate nucleus tissue. Biochem Pharmacol. 1983 Oct 01; 32(19):2873-80. PMID: 6626260.
    Citations: 1     Fields:    Translation:AnimalsCells
  156. Cohen SA, Neumeyer JL. Aporphines. 50. Kinetics of solvolysis of N-(2-chloroethyl)norapomorphine, an irreversible dopamine receptor antagonist. J Med Chem. 1983 Oct; 26(10):1348-53. PMID: 6620296.
    Citations:    Fields:    Translation:Animals
  157. Bradbury AJ, Costall B, Naylor RJ, Neumeyer JL. Motor inhibition induced by aporphine derivatives in the mouse. J Pharm Pharmacol. 1983 Aug; 35(8):494-9. PMID: 6137533.
    Citations: 2     Fields:    Translation:Animals
  158. Maksoud HM, Kuttab SH, Neumeyer JL, Vouros P. Analysis of N-n-propylnorapomorphine in plasma and tissue by capillary gas chromatography--electron-capture detection. J Chromatogr. 1983 May 13; 274:149-59. PMID: 6874818.
    Citations:    Fields:    Translation:Animals
  159. Neumeyer JL, Reischig D, Arana GW, Campbell A, Baldessarini RJ, Kula NS, Watling KJ. Aporphines. 48. Enantioselectivity of (R)-(-)- and (S)-(+)-N-n-propylnorapomorphine on dopamine receptors. J Med Chem. 1983 Apr; 26(4):516-21. PMID: 6682147.
    Citations: 2     Fields:    Translation:HumansAnimals
  160. Neumeyer JL, Szabo S. (-)-10,11-Methylenedioxy-N-propylnoraporphine, an orally effective dopamine agonist and duodenal antiulcerogen in the rat. Eur J Pharmacol. 1983 Mar 25; 88(2-3):273-4. PMID: 6852114.
    Citations: 2     Fields:    Translation:Animals
  161. Jackson EA, Neumeyer JL, Kelly PH. Behavioral activity of some novel aporphines in rats with 6-hydroxydopamine lesions of caudate or nucleus accumbens. Eur J Pharmacol. 1983 Jan 28; 87(1):15-23. PMID: 6404639.
    Citations: 3     Fields:    Translation:HumansAnimals
  162. Anlezark GM, Blackwood DH, Meldrum BS, Ram VJ, Neumeyer JL. Comparative assessment of dopamine agonist aporphines as anticonvulsants in two models of reflex epilepsy. Psychopharmacology (Berl). 1983; 81(2):135-9. PMID: 6415743.
    Citations: 1     Fields:    Translation:Animals
  163. Sperk G, Campbell A, Baldessarini RJ, Stoll A, Neumeyer JL. Tissue levels of N-n-propylnorapomorphine after treatment with (-)10,11-methylenedioxy-N-n-propylnoraporphine, an orally long-acting prodrug active at central dopamine receptors. Neuropharmacology. 1982 Dec; 21(12):1311-6. PMID: 6891445.
    Citations:    Fields:    Translation:HumansAnimals