Harvard Catalyst Profiles

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Haribabu Arthanari, Ph.D.

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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01GM136859 (ARTHANARI, HARIBABU) Jun 1, 2020 - Mar 31, 2025
    NMR Fingerprinting: Leveraging optimal control pulse design, tailored isotope labeling, and machine learning to study intractable proteins
    Role: Principal Investigator
  2. K01DK085198 (ARTHANARI, HARIBABU) Sep 30, 2010 - Aug 31, 2014
    Novel targets to regulate NF-kB & SREBP activity: an approach to combat diabetes
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Fischer PD, Chowdhury AS, Bartholow T, Basu S, Baggs E, Cox HS, Matošin S, Burkart MD, Warner L, Nagarajan R, Arthanari H. Carrier protein mediated cargo sensing in quorum signal synthases. Chem Commun (Camb). 2023 Jan 24; 59(8):1014-1017. PMID: 36645064.
    Citations:    Fields:    
  2. Yin M, Izadi M, Tenglin K, Viennet T, Zhai L, Zheng G, Arthanari H, Dassama LMK, Orkin SH. Evolution of nanobodies specific for BCL11A. Proc Natl Acad Sci U S A. 2023 Jan 17; 120(3):e2218959120. PMID: 36626555.
    Citations:    Fields:    Translation:Humans
  3. Li J, Wang L, Hahn Q, Nowak RP, Viennet T, Orellana EA, Roy Burman SS, Yue H, Hunkeler M, Fontana P, Wu H, Arthanari H, Fischer ES, Gregory RI. Structural basis of regulated m7G tRNA modification by METTL1-WDR4. Nature. 2023 Jan; 613(7943):391-397. PMID: 36599985.
    Citations:    Fields:    Translation:HumansCells
  4. Fathalla RK, Fröhner W, Bader CD, Fischer PD, Dahlem C, Chatterjee D, Mathea S, Kiemer AK, Arthanari H, Müller R, Abdel-Halim M, Ducho C, Engel M. Identification and Biochemical Characterization of Pyrrolidinediones as Novel Inhibitors of the Bacterial Enzyme MurA. J Med Chem. 2022 11 10; 65(21):14740-14763. PMID: 36269107.
    Citations:    Fields:    Translation:HumansCells
  5. Dubey A, Viennet T, Chhabra S, Takeuchi K, Seo HC, Bermel W, Frueh DP, Arthanari H. 15N-Detected TROSY NMR experiments to study large disordered proteins in high-field magnets. Chem Commun (Camb). 2022 Aug 23; 58(68):9512-9515. PMID: 35920752; PMCID: PMC9578535.
    Citations:    Fields:    Translation:Cells
  6. Bae H, Viennet T, Park E, Chu N, Salguero A, Eck MJ, Arthanari H, Cole PA. PH domain-mediated autoinhibition and oncogenic activation of Akt. Elife. 2022 08 15; 11. PMID: 35968932; PMCID: PMC9417420.
    Citations:    Fields:    Translation:Cells
  7. Friedrich D, Marintchev A, Arthanari H. The metaphorical swiss army knife: The multitude and diverse roles of HEAT domains in eukaryotic translation initiation. Nucleic Acids Res. 2022 06 10; 50(10):5424-5442. PMID: 35552740; PMCID: PMC9177959.
    Citations:    Fields:    Translation:Cells
  8. Gorgulla C, Jayaraj A, Fackeldey K, Arthanari H. Emerging frontiers in virtual drug discovery: From quantum mechanical methods to deep learning approaches. Curr Opin Chem Biol. 2022 08; 69:102156. PMID: 35576813.
    Citations:    Fields:    
  9. Rossetti GG, Ossorio MA, Rempel S, Kratzel A, Dionellis VS, Barriot S, Tropia L, Gorgulla C, Arthanari H, Thiel V, Mohr P, Gamboni R, Halazonetis TD. Non-covalent SARS-CoV-2 Mpro inhibitors developed from in silico screen hits. Sci Rep. 2022 02 15; 12(1):2505. PMID: 35169179; PMCID: PMC8847420.
    Citations: 4     Fields:    Translation:HumansCells
  10. Calvo IA, Sharma S, Paulo JA, Gulka AOD, Boeszoermenyi A, Zhang J, Lombana JM, Palmieri CM, Laviolette LA, Arthanari H, Iliopoulos O, Gygi SP, Motamedi M. The fission yeast FLCN/FNIP complex augments TORC1 repression or activation in response to amino acid (AA) availability. iScience. 2021 Nov 19; 24(11):103338. PMID: 34805795; PMCID: PMC8590082.
  11. Dempsey DR, Viennet T, Iwase R, Park E, Henriquez S, Chen Z, Jeliazkov JR, Palanski BA, Phan KL, Coote P, Gray JJ, Eck MJ, Gabelli SB, Arthanari H, Cole PA. The structural basis of PTEN regulation by multi-site phosphorylation. Nat Struct Mol Biol. 2021 10; 28(10):858-868. PMID: 34625746; PMCID: PMC8549118.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  12. Fonseca-Ornelas L, Viennet T, Rovere M, Jiang H, Liu L, Nuber S, Ericsson M, Arthanari H, Selkoe DJ. Altered conformation of a-synuclein drives dysfunction of synaptic vesicles in a synaptosomal model of Parkinson's disease. Cell Rep. 2021 07 06; 36(1):109333. PMID: 34233191; PMCID: PMC8552450.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  13. Gorgulla C, Çinaroglu SS, Fischer PD, Fackeldey K, Wagner G, Arthanari H. VirtualFlow Ants-Ultra-Large Virtual Screenings with Artificial Intelligence Driven Docking Algorithm Based on Ant Colony Optimization. Int J Mol Sci. 2021 May 28; 22(11). PMID: 34071676.
    Citations: 1     Fields:    Translation:Cells
  14. Dubey A, Stoyanov N, Viennet T, Chhabra S, Elter S, Borggräfe J, Viegas A, Nowak RP, Burdzhiev N, Petrov O, Fischer ES, Etzkorn M, Gelev V, Arthanari H. Local Deuteration Enables NMR Observation of Methyl Groups in Proteins from Eukaryotic and Cell-Free Expression Systems. Angew Chem Int Ed Engl. 2021 06 14; 60(25):13783-13787. PMID: 33768661; PMCID: PMC8251921.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  15. Fischer PD, Papadopoulos E, Dempersmier JM, Wang ZF, Nowak RP, Donovan KA, Kalabathula J, Gorgulla C, Junghanns PPM, Kabha E, Dimitrakakis N, Petrov OI, Mitsiades C, Ducho C, Gelev V, Fischer ES, Wagner G, Arthanari H. A biphenyl inhibitor of eIF4E targeting an internal binding site enables the design of cell-permeable PROTAC-degraders. Eur J Med Chem. 2021 Jul 05; 219:113435. PMID: 33892272; PMCID: PMC8846605.
    Citations: 2     Fields:    Translation:HumansCells
  16. Arthanari H, Chary KVR, Szyperski T, Ramanathan KV, Hosur RV, Suryaprakash N, Raghothama S, Jagannathan NR, Norton RS, Prabhakaran EN, Kondaish P, Mukherjee SP, Adiga SK, Vadrevu R, Bhunia A, Joseph D. Hanudatta S. Atreya (1974-2020). Magn Reson Chem. 2021 03; 59(3):201-212. PMID: 33565121.
    Citations:    Fields:    
  17. Coote P, Bermel W, Arthanari H. Optimization of phase dispersion enables broadband excitation without homonuclear coupling artifacts. J Magn Reson. 2021 04; 325:106928. PMID: 33652210; PMCID: PMC8012116.
    Citations:    Fields:    
  18. Jayaraj A, Schwanz HA, Spencer DJ, Bhasin S, Hamilton JA, Jayaram B, Goldman AL, Krishna M, Krishnan M, Shah A, Jin Z, Krenzel E, Nair SN, Ramesh S, Guo W, Wagner G, Arthanari H, Peng L, Lawney B, Jasuja R. Allosterically Coupled Multisite Binding of Testosterone to Human Serum Albumin. Endocrinology. 2021 02 01; 162(2). PMID: 33125473.
    Citations: 2     Fields:    Translation:Cells
  19. Pal I, Mishra N, Herrera AI, Dubey A, Arthanari H, Geisbrecht BV, Prakash O. 1H, 15N, and 13C backbone resonance assignments of the C4b-binding region from the S. aureus extracellular adherence protein. Biomol NMR Assign. 2021 04; 15(1):183-186. PMID: 33423171; PMCID: PMC7979526.
    Citations:    Fields:    Translation:Cells
  20. Gorgulla C, Padmanabha Das KM, Leigh KE, Cespugli M, Fischer PD, Wang ZF, Tesseyre G, Pandita S, Shnapir A, Calderaio A, Gechev M, Rose A, Lewis N, Hutcheson C, Yaffe E, Luxenburg R, Herce HD, Durmaz V, Halazonetis TD, Fackeldey K, Patten JJ, Chuprina A, Dziuba I, Plekhova A, Moroz Y, Radchenko D, Tarkhanova O, Yavnyuk I, Gruber C, Yust R, Payne D, Näär AM, Namchuk MN, Davey RA, Wagner G, Kinney J, Arthanari H. A multi-pronged approach targeting SARS-CoV-2 proteins using ultra-large virtual screening. iScience. 2021 Feb 19; 24(2):102021. PMID: 33426509.
    Citations: 15     
  21. Li X, Mizsei R, Tan K, Mallis RJ, Duke-Cohan JS, Akitsu A, Tetteh PW, Dubey A, Hwang W, Wagner G, Lang MJ, Arthanari H, Wang JH, Reinherz EL. Pre-T cell receptors topologically sample self-ligands during thymocyte ß-selection. Science. 2021 01 08; 371(6525):181-185. PMID: 33335016; PMCID: PMC8011828.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  22. Gorgulla C, Fackeldey K, Wagner G, Arthanari H. Accounting of Receptor Flexibility in Ultra-Large Virtual Screens with VirtualFlow Using a Grey Wolf Optimization Method. Supercomput Front Innov. 2020 Nov 07; 7(3):4-12. PMID: 34693068.
  23. Behera SP, Dubey A, Chen WN, De Paula VS, Zhang M, Sgourakis NG, Bermel W, Wagner G, Coote PW, Arthanari H. Nearest-neighbor NMR spectroscopy: categorizing spectral peaks by their adjacent nuclei. Nat Commun. 2020 11 03; 11(1):5547. PMID: 33144564.
    Citations: 3     Fields:    Translation:HumansCells
  24. Dubey A, Takeuchi K, Reibarkh M, Arthanari H. Correction to: The role of NMR in leveraging dynamics and entropy in drug design. J Biomol NMR. 2020 Nov; 74(10-11):499-500. PMID: 32951153.
    Citations:    Fields:    
  25. Chu N, Viennet T, Bae H, Salguero A, Boeszoermenyi A, Arthanari H, Cole PA. The structural determinants of PH domain-mediated regulation of Akt revealed by segmental labeling. Elife. 2020 08 03; 9. PMID: 32744507.
    Citations: 13     Fields:    Translation:HumansCells
  26. Dubey A, Takeuchi K, Reibarkh M, Arthanari H. The role of NMR in leveraging dynamics and entropy in drug design. J Biomol NMR. 2020 Nov; 74(10-11):479-498. PMID: 32720098.
    Citations: 1     Fields:    Translation:Cells
  27. Gorgulla C, Padmanabha Das KM, Leigh KE, Cespugli M, Fischer PD, Wang ZF, Tesseyre G, Pandita S, Shnapir A, Calderaio A, Gechev M, Rose A, Lewis N, Hutcheson C, Yaffe E, Luxenburg R, Herce HD, Durmaz V, Halazonetis TD, Fackeldey K, Patten JJ, Chuprina A, Dziuba I, Plekhova A, Moroz Y, Radchenko D, Tarkhanova O, Yavnyuk I, Gruber C, Yust R, Payne D, Näär AM, Namchuk MN, Davey RA, Wagner G, Kinney J, Arthanari H. A Multi-Pronged Approach Targeting SARS-CoV-2 Proteins Using Ultra-Large Virtual Screening. ChemRxiv. 2020 Jul 24. PMID: 33200116; PMCID: PMC7668741.
    Citations: 1     
  28. Boeszoermenyi A, Ogórek B, Jain A, Arthanari H, Wagner G. The precious fluorine on the ring: fluorine NMR for biological systems. J Biomol NMR. 2020 Sep; 74(8-9):365-379. PMID: 32651751.
    Citations: 4     Fields:    Translation:Cells
  29. Gorgulla C, Boeszoermenyi A, Wang ZF, Fischer PD, Coote PW, Padmanabha Das KM, Malets YS, Radchenko DS, Moroz YS, Scott DA, Fackeldey K, Hoffmann M, Iavniuk I, Wagner G, Arthanari H. An open-source drug discovery platform enables ultra-large virtual screens. Nature. 2020 04; 580(7805):663-668. PMID: 32152607; PMCID: PMC8352709.
    Citations: 68     Fields:    
  30. Tokunaga Y, Viennet T, Arthanari H, Takeuchi K. Spotlight on the Ballet of Proteins: The Structural Dynamic Properties of Proteins Illuminated by Solution NMR. Int J Mol Sci. 2020 Mar 06; 21(5). PMID: 32155847.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  31. Shin D, Gorgulla C, Boursier ME, Rexrode N, Brown EC, Arthanari H, Blackwell HE, Nagarajan R. N-Acyl Homoserine Lactone Analog Modulators of the Pseudomonas aeruginosa Rhll Quorum Sensing Signal Synthase. ACS Chem Biol. 2019 10 18; 14(10):2305-2314. PMID: 31545595.
    Citations: 5     Fields:    Translation:Cells
  32. Arthanari H, Takeuchi K, Dubey A, Wagner G. Emerging solution NMR methods to illuminate the structural and dynamic properties of proteins. Curr Opin Struct Biol. 2019 10; 58:294-304. PMID: 31327528.
    Citations: 8     Fields:    
  33. Takeuchi K, Baskaran K, Arthanari H. Structure determination using solution NMR: Is it worth the effort? J Magn Reson. 2019 09; 306:195-201. PMID: 31345771.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  34. Hjortness MK, Riccardi L, Hongdusit A, Ruppe S, Zhao M, Kim EY, Zwart PH, Sankaran B, Arthanari H, Sousa MC, De Vivo M, Fox JM. Correction to "Abietane-Type Diterpenoids Inhibit Protein Tyrosine Phosphatases by Stabilizing an Inactive Enzyme Conformation". Biochemistry. 2019 06 18; 58(24):2797. PMID: 31181901.
    Citations:    Fields:    
  35. Boeszoermenyi A, Chhabra S, Dubey A, Radeva DL, Burdzhiev NT, Chanev CD, Petrov OI, Gelev VM, Zhang M, Anklin C, Kovacs H, Wagner G, Kuprov I, Takeuchi K, Arthanari H. Aromatic 19F-13C TROSY: a background-free approach to probe biomolecular structure, function, and dynamics. Nat Methods. 2019 04; 16(4):333-340. PMID: 30858598.
    Citations: 25     Fields:    Translation:Cells
  36. Mallis RJ, Brazin KN, Duke-Cohan JS, Hwang W, Wang JH, Wagner G, Arthanari H, Lang MJ, Reinherz EL. NMR: an essential structural tool for integrative studies of T cell development, pMHC ligand recognition and TCR mechanobiology. J Biomol NMR. 2019 Jul; 73(6-7):319-332. PMID: 30815789.
    Citations: 8     Fields:    Translation:HumansCells
  37. Herrera AI, Dubey A, Geisbrecht BV, Arthanari H, Prakash O. Backbone resonance assignments of innate immune evasion protein EapH2 from the S. aureus. Biomol NMR Assign. 2019 04; 13(1):219-222. PMID: 30729401.
    Citations: 1     Fields:    Translation:Cells
  38. Brazin KN, Mallis RJ, Boeszoermenyi A, Feng Y, Yoshizawa A, Reche PA, Kaur P, Bi K, Hussey RE, Duke-Cohan JS, Song L, Wagner G, Arthanari H, Lang MJ, Reinherz EL. The T Cell Antigen Receptor a Transmembrane Domain Coordinates Triggering through Regulation of Bilayer Immersion and CD3 Subunit Associations. Immunity. 2018 11 20; 49(5):829-841.e6. PMID: 30389415.
    Citations: 24     Fields:    Translation:Cells
  39. Robson S, Arthanari H, Hyberts SG, Wagner G. Nonuniform Sampling for NMR Spectroscopy. Methods Enzymol. 2019; 614:263-291. PMID: 30611427.
    Citations: 8     Fields:    Translation:Humans
  40. Hjortness MK, Riccardi L, Hongdusit A, Ruppe S, Zhao M, Kim EY, Zwart PH, Sankaran B, Arthanari H, Sousa MC, De Vivo M, Fox JM. Abietane-Type Diterpenoids Inhibit Protein Tyrosine Phosphatases by Stabilizing an Inactive Enzyme Conformation. Biochemistry. 2018 10 09; 57(40):5886-5896. PMID: 30169954; PMCID: PMC6219988.
    Citations: 3     Fields:    Translation:HumansCells
  41. Coote PW, Robson SA, Dubey A, Boeszoermenyi A, Zhao M, Wagner G, Arthanari H. Optimal control theory enables homonuclear decoupling without Bloch-Siegert shifts in NMR spectroscopy. Nat Commun. 2018 08 01; 9(1):3014. PMID: 30069002.
    Citations: 6     Fields:    Translation:Humans
  42. Meleppattu S, Arthanari H, Zinoviev A, Boeszoermenyi A, Wagner G, Shapira M, Léger-Abraham M. Structural basis for LeishIF4E-1 modulation by an interacting protein in the human parasite Leishmania major. Nucleic Acids Res. 2018 04 20; 46(7):3791-3801. PMID: 29562352; PMCID: PMC5909430.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  43. Chhabra S, Fischer P, Takeuchi K, Dubey A, Ziarek JJ, Boeszoermenyi A, Mathieu D, Bermel W, Davey NE, Wagner G, Arthanari H. 15N detection harnesses the slow relaxation property of nitrogen: Delivering enhanced resolution for intrinsically disordered proteins. Proc Natl Acad Sci U S A. 2018 02 20; 115(8):E1710-E1719. PMID: 29432148.
    Citations: 9     Fields:    Translation:Cells
  44. Robson SA, Takeuchi K, Boeszoermenyi A, Coote PW, Dubey A, Hyberts S, Wagner G, Arthanari H. Mixed pyruvate labeling enables backbone resonance assignment of large proteins using a single experiment. Nat Commun. 2018 01 24; 9(1):356. PMID: 29367739.
    Citations: 8     Fields:    Translation:Cells
  45. Takeuchi K, Arthanari H, Shimada I, Wagner G. Erratum to: Nitrogen detected TROSY at high field yields high resolution and sensitivity for protein NMR. J Biomol NMR. 2017 12; 69(4):245. PMID: 29230599.
    Citations:    Fields:    
  46. Deng J, Wang ES, Jenkins RW, Li S, Dries R, Yates K, Chhabra S, Huang W, Liu H, Aref AR, Ivanova E, Paweletz CP, Bowden M, Zhou CW, Herter-Sprie GS, Sorrentino JA, Bisi JE, Lizotte PH, Merlino AA, Quinn MM, Bufe LE, Yang A, Zhang Y, Zhang H, Gao P, Chen T, Cavanaugh ME, Rode AJ, Haines E, Roberts PJ, Strum JC, Richards WG, Lorch JH, Parangi S, Gunda V, Boland GM, Bueno R, Palakurthi S, Freeman GJ, Ritz J, Haining WN, Sharpless NE, Arthanari H, Shapiro GI, Barbie DA, Gray NS, Wong KK. CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell Activation. Cancer Discov. 2018 02; 8(2):216-233. PMID: 29101163; PMCID: PMC5809273.
    Citations: 211     Fields:    Translation:HumansAnimalsCells
  47. Mallis RJ, Arthanari H, Lang MJ, Reinherz EL, Wagner G. NMR-directed design of pre-TCRß and pMHC molecules implies a distinct geometry for pre-TCR relative to aßTCR recognition of pMHC. J Biol Chem. 2018 01 19; 293(3):754-766. PMID: 29101227.
    Citations: 3     Fields:    Translation:Cells
  48. Ilic S, Akabayov SR, Froimovici R, Meiry R, Vilenchik D, Hernandez A, Arthanari H, Akabayov B. Modulation of RNA primer formation by Mn(II)-substituted T7 DNA primase. Sci Rep. 2017 07 19; 7(1):5797. PMID: 28724886.
    Citations: 1     Fields:    Translation:Cells
  49. Sekiyama N, Boeszoermenyi A, Arthanari H, Wagner G, Léger-Abraham M. 1H, 13C, and 15N backbone chemical shift assignments of 4E-BP144-87 and 4E-BP144-87 bound to eIF4E. Biomol NMR Assign. 2017 Oct; 11(2):187-191. PMID: 28589219; PMCID: PMC5693643.
    Citations:    Fields:    Translation:HumansCells
  50. Coote P, Anklin C, Massefski W, Wagner G, Arthanari H. Rapid convergence of optimal control in NMR using numerically-constructed toggling frames. J Magn Reson. 2017 08; 281:94-103. PMID: 28578162; PMCID: PMC5541913.
    Citations: 4     Fields:    
  51. Obayashi E, Luna RE, Nagata T, Martin-Marcos P, Hiraishi H, Singh CR, Erzberger JP, Zhang F, Arthanari H, Morris J, Pellarin R, Moore C, Harmon I, Papadopoulos E, Yoshida H, Nasr ML, Unzai S, Thompson B, Aube E, Hustak S, Stengel F, Dagraca E, Ananbandam A, Gao P, Urano T, Hinnebusch AG, Wagner G, Asano K. Molecular Landscape of the Ribosome Pre-initiation Complex during mRNA Scanning: Structural Role for eIF3c and Its Control by eIF5. Cell Rep. 2017 03 14; 18(11):2651-2663. PMID: 28297669.
    Citations: 28     Fields:    Translation:AnimalsCells
  52. Takeuchi K, Arthanari H, Wagner G. Perspective: revisiting the field dependence of TROSY sensitivity. J Biomol NMR. 2016 12; 66(4):221-225. PMID: 27866370; PMCID: PMC5218892.
    Citations: 9     Fields:    
  53. Ilic S, Akabayov SR, Arthanari H, Wagner G, Richardson CC, Akabayov B. Identification of DNA primase inhibitors via a combined fragment-based and virtual screening. Sci Rep. 2016 11 02; 6:36322. PMID: 27805033.
    Citations: 6     Fields:    Translation:HumansCells
  54. Sun ZJ, Bhanu MK, Allan MG, Arthanari H, Wagner G, Hanna J. Solution Structure of the Cuz1 AN1 Zinc Finger Domain: An Exposed LDFLP Motif Defines a Subfamily of AN1 Proteins. PLoS One. 2016; 11(9):e0163660. PMID: 27662200.
    Citations: 1     Fields:    
  55. Coote P, Bermel W, Wagner G, Arthanari H. Analytical optimization of active bandwidth and quality factor for TOCSY experiments in NMR spectroscopy. J Biomol NMR. 2016 09; 66(1):9-20. PMID: 27515670; PMCID: PMC5175489.
    Citations: 1     Fields:    
  56. Nishikawa JL, Boeszoermenyi A, Vale-Silva LA, Torelli R, Posteraro B, Sohn YJ, Ji F, Gelev V, Sanglard D, Sanguinetti M, Sadreyev RI, Mukherjee G, Bhyravabhotla J, Buhrlage SJ, Gray NS, Wagner G, Näär AM, Arthanari H. Inhibiting fungal multidrug resistance by disrupting an activator-Mediator interaction. Nature. 2016 Feb 25; 530(7591):485-9. PMID: 26886795.
    Citations: 54     Fields:    Translation:AnimalsCells
  57. Takeuchi K, Arthanari H, Imai M, Wagner G, Shimada I. Nitrogen-detected TROSY yields comparable sensitivity to proton-detected TROSY for non-deuterated, large proteins under physiological salt conditions. J Biomol NMR. 2016 Feb; 64(2):143-51. PMID: 26800993; PMCID: PMC4871712.
    Citations: 15     Fields:    Translation:Cells
  58. Takeuchi K, Arthanari H, Shimada I, Wagner G. Nitrogen detected TROSY at high field yields high resolution and sensitivity for protein NMR. J Biomol NMR. 2015 Dec; 63(4):323-331. PMID: 26497830; PMCID: PMC4749451.
    Citations: 22     Fields:    Translation:Cells
  59. Boeszoermenyi A, Nagy HM, Arthanari H, Pillip CJ, Lindermuth H, Luna RE, Wagner G, Zechner R, Zangger K, Oberer M. Structure of a CGI-58 motif provides the molecular basis of lipid droplet anchoring. J Biol Chem. 2015 Oct 30; 290(44):26361-72. PMID: 26350461.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  60. Mallis RJ, Reinherz EL, Wagner G, Arthanari H. Backbone resonance assignment of N15, N30 and D10 T cell receptor ß subunits. Biomol NMR Assign. 2016 Apr; 10(1):35-9. PMID: 26275917.
    Citations: 3     Fields:    Translation:Cells
  61. Sekiyama N, Arthanari H, Papadopoulos E, Rodriguez-Mias RA, Wagner G, Léger-Abraham M. Molecular mechanism of the dual activity of 4EGI-1: Dissociating eIF4G from eIF4E but stabilizing the binding of unphosphorylated 4E-BP1. Proc Natl Acad Sci U S A. 2015 Jul 28; 112(30):E4036-45. PMID: 26170285; PMCID: PMC4522750.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  62. Leigh KE, Sharma M, Mansueto MS, Boeszoermenyi A, Filman DJ, Hogle JM, Wagner G, Coen DM, Arthanari H. Structure of a herpesvirus nuclear egress complex subunit reveals an interaction groove that is essential for viral replication. Proc Natl Acad Sci U S A. 2015 Jul 21; 112(29):9010-5. PMID: 26150520; PMCID: PMC4517201.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  63. Mallis RJ, Bai K, Arthanari H, Hussey RE, Handley M, Li Z, Chingozha L, Duke-Cohan JS, Lu H, Wang JH, Zhu C, Wagner G, Reinherz EL. Pre-TCR ligand binding impacts thymocyte development before aßTCR expression. Proc Natl Acad Sci U S A. 2015 Jul 07; 112(27):8373-8. PMID: 26056289; PMCID: PMC4500245.
    Citations: 31     Fields:    Translation:AnimalsCells
  64. O'Day E, Le MTN, Imai S, Tan SM, Kirchner R, Arthanari H, Hofmann O, Wagner G, Lieberman J. An RNA-binding Protein, Lin28, Recognizes and Remodels G-quartets in the MicroRNAs (miRNAs) and mRNAs It Regulates. J Biol Chem. 2015 Jul 17; 290(29):17909-17922. PMID: 26045559.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  65. Yi T, Arthanari H, Akabayov B, Song H, Papadopoulos E, Qi HH, Jedrychowski M, Güttler T, Guo C, Luna RE, Gygi SP, Huang SA, Wagner G. eIF1A augments Ago2-mediated Dicer-independent miRNA biogenesis and RNA interference. Nat Commun. 2015 May 28; 6:7194. PMID: 26018492.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  66. Milbradt AG, Arthanari H, Takeuchi K, Boeszoermenyi A, Hagn F, Wagner G. Increased resolution of aromatic cross peaks using alternate 13C labeling and TROSY. J Biomol NMR. 2015 Jul; 62(3):291-301. PMID: 25957757; PMCID: PMC4782774.
    Citations: 11     Fields:    
  67. Hofer P, Boeszoermenyi A, Jaeger D, Feiler U, Arthanari H, Mayer N, Zehender F, Rechberger G, Oberer M, Zimmermann R, Lass A, Haemmerle G, Breinbauer R, Zechner R, Preiss-Landl K. Fatty Acid-binding Proteins Interact with Comparative Gene Identification-58 Linking Lipolysis with Lipid Ligand Shuttling. J Biol Chem. 2015 Jul 24; 290(30):18438-53. PMID: 25953897.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  68. Brazin KN, Mallis RJ, Li C, Keskin DB, Arthanari H, Gao Y, Wu SL, Karger BL, Wagner G, Reinherz EL. Constitutively oxidized CXXC motifs within the CD3 heterodimeric ectodomains of the T cell receptor complex enforce the conformation of juxtaposed segments. J Biol Chem. 2015 Jan 2; 290(1):239. PMID: 25556239.
  69. Papadopoulos E, Jenni S, Kabha E, Takrouri KJ, Yi T, Salvi N, Luna RE, Gavathiotis E, Mahalingam P, Arthanari H, Rodriguez-Mias R, Yefidoff-Freedman R, Aktas BH, Chorev M, Halperin JA, Wagner G. Structure of the eukaryotic translation initiation factor eIF4E in complex with 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G. Proc Natl Acad Sci U S A. 2014 Aug 05; 111(31):E3187-95. PMID: 25049413.
    Citations: 36     Fields:    Translation:HumansCells
  70. Coote P, Leigh KE, Yu TY, Khaneja N, Wagner G, Arthanari H. A new broadband homonuclear mixing pulse for NMR with low applied power. J Chem Phys. 2014 Jul 14; 141(2):024201. PMID: 25028012.
    Citations: 1     Fields:    
  71. Linser R, Gelev V, Hagn F, Arthanari H, Hyberts SG, Wagner G. Selective methyl labeling of eukaryotic membrane proteins using cell-free expression. J Am Chem Soc. 2014 Aug 13; 136(32):11308-10. PMID: 24937763.
    Citations: 10     Fields:    Translation:HumansCells
  72. Brazin KN, Mallis RJ, Li C, Keskin DB, Arthanari H, Gao Y, Wu SL, Karger BL, Wagner G, Reinherz EL. Constitutively oxidized CXXC motifs within the CD3 heterodimeric ectodomains of the T cell receptor complex enforce the conformation of juxtaposed segments. J Biol Chem. 2014 Jul 04; 289(27):18880-92. PMID: 24849600.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  73. Hyberts SG, Arthanari H, Robson SA, Wagner G. Perspectives in magnetic resonance: NMR in the post-FFT era. J Magn Reson. 2014 Apr; 241:60-73. PMID: 24656081.
    Citations: 54     Fields:    Translation:HumansAnimals
  74. Luna RE, Arthanari H, Hiraishi H, Akabayov B, Tang L, Cox C, Markus MA, Luna LE, Ikeda Y, Watanabe R, Bedoya E, Yu C, Alikhan S, Wagner G, Asano K. The interaction between eukaryotic initiation factor 1A and eIF5 retains eIF1 within scanning preinitiation complexes. Biochemistry. 2013 Dec 31; 52(52):9510-8. PMID: 24319994.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  75. Boeszoermenyi A, Schmidt JC, Cheeseman IM, Oberer M, Wagner G, Arthanari H. Resonance assignments of the microtubule-binding domain of the C. elegans spindle and kinetochore-associated protein 1. Biomol NMR Assign. 2014 Oct; 8(2):275-8. PMID: 23765286; PMCID: PMC3823668.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  76. Coote P, Arthanari H, Yu TY, Natarajan A, Wagner G, Khaneja N. Pulse design for broadband correlation NMR spectroscopy by multi-rotating frames. J Biomol NMR. 2013 Mar; 55(3):291-302. PMID: 23420125.
    Citations: 4     Fields:    Translation:Humans
  77. Schmidt JC, Arthanari H, Boeszoermenyi A, Dashkevich NM, Wilson-Kubalek EM, Monnier N, Markus M, Oberer M, Milligan RA, Bathe M, Wagner G, Grishchuk EL, Cheeseman IM. The kinetochore-bound Ska1 complex tracks depolymerizing microtubules and binds to curved protofilaments. Dev Cell. 2012 Nov 13; 23(5):968-80. PMID: 23085020; PMCID: PMC3500403.
    Citations: 108     Fields:    Translation:HumansAnimalsCells
  78. Luna RE, Arthanari H, Hiraishi H, Nanda J, Martin-Marcos P, Markus MA, Akabayov B, Milbradt AG, Luna LE, Seo HC, Hyberts SG, Fahmy A, Reibarkh M, Miles D, Hagner PR, O'Day EM, Yi T, Marintchev A, Hinnebusch AG, Lorsch JR, Asano K, Wagner G. The C-terminal domain of eukaryotic initiation factor 5 promotes start codon recognition by its dynamic interplay with eIF1 and eIF2ß. Cell Rep. 2012 Jun 28; 1(6):689-702. PMID: 22813744.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  79. Bezsonova I, Rujan I, Bobenchik AM, Gorbatyuk V, Maciejewski MW, Gorbatyuk O, Hao B, Arthanari H, Mamoun CB, Hoch JC. (1)H, (13)C, and (15)N chemical shift assignments for PfPMT, a phosphoethanolamine methyltransferase from Plasmodium falciparum. Biomol NMR Assign. 2013 Apr; 7(1):17-20. PMID: 22392340.
    Citations: 3     Fields:    Translation:Animals
  80. Hyberts SG, Milbradt AG, Wagner AB, Arthanari H, Wagner G. Application of iterative soft thresholding for fast reconstruction of NMR data non-uniformly sampled with multidimensional Poisson Gap scheduling. J Biomol NMR. 2012 Apr; 52(4):315-27. PMID: 22331404.
    Citations: 173     Fields:    
  81. Hyberts SG, Arthanari H, Wagner G. Applications of non-uniform sampling and processing. Top Curr Chem. 2012; 316:125-48. PMID: 21796515.
    Citations: 56     Fields:    
  82. Shaw BF, Schneider GF, Arthanari H, Narovlyansky M, Moustakas D, Durazo A, Wagner G, Whitesides GM. Complexes of native ubiquitin and dodecyl sulfate illustrate the nature of hydrophobic and electrostatic interactions in the binding of proteins and surfactants. J Am Chem Soc. 2011 Nov 09; 133(44):17681-95. PMID: 21939262.
    Citations: 12     Fields:    Translation:Cells
  83. Narayanan S, Arthanari H, Wolfe MS, Wagner G. Molecular characterization of disrupted in schizophrenia-1 risk variant S704C reveals the formation of altered oligomeric assembly. J Biol Chem. 2011 Dec 23; 286(51):44266-44276. PMID: 21998303.
    Citations: 19     Fields:    Translation:HumansCells
  84. Crenshaw CM, Wade JE, Arthanari H, Frueh D, Lane BF, Núñez ME. Hidden in plain sight: subtle effects of the 8-oxoguanine lesion on the structure, dynamics, and thermodynamics of a 15-base pair oligodeoxynucleotide duplex. Biochemistry. 2011 Oct 04; 50(39):8463-77. PMID: 21902242.
    Citations: 22     Fields:    Translation:Cells
  85. Schuyler AD, Maciejewski MW, Arthanari H, Hoch JC. Knowledge-based nonuniform sampling in multidimensional NMR. J Biomol NMR. 2011 Jul; 50(3):247-62. PMID: 21626215.
    Citations: 16     Fields:    
  86. Li JS, Ruths J, Yu TY, Arthanari H, Wagner G. Optimal pulse design in quantum control: a unified computational method. Proc Natl Acad Sci U S A. 2011 Feb 01; 108(5):1879-84. PMID: 21245345.
    Citations: 6     Fields:    
  87. Arthanari H, Wagner G, Khaneja N. Heteronuclear decoupling by multiple rotating frame technique. J Magn Reson. 2011 Mar; 209(1):8-18. PMID: 21227724.
    Citations:    Fields:    
  88. Shaw BF, Arthanari H, Narovlyansky M, Durazo A, Frueh DP, Pollastri MP, Lee A, Bilgicer B, Gygi SP, Wagner G, Whitesides GM. Neutralizing positive charges at the surface of a protein lowers its rate of amide hydrogen exchange without altering its structure or increasing its thermostability. J Am Chem Soc. 2010 Dec 15; 132(49):17411-25. PMID: 21090618.
    Citations: 9     Fields:    Translation:AnimalsCells
  89. Frueh DP, Leed A, Arthanari H, Koglin A, Walsh CT, Wagner G. Time-shared HSQC-NOESY for accurate distance constraints measured at high-field in (15)N-(13)C-ILV methyl labeled proteins. J Biomol NMR. 2009 Nov; 45(3):311-8. PMID: 19728110.
    Citations: 7     Fields:    
  90. Frueh DP, Arthanari H, Koglin A, Walsh CT, Wagner G. A double TROSY hNCAnH experiment for efficient assignment of large and challenging proteins. J Am Chem Soc. 2009 Sep 16; 131(36):12880-1. PMID: 19702261.
    Citations: 8     Fields:    Translation:Cells
  91. Hyberts SG, Frueh DP, Arthanari H, Wagner G. FM reconstruction of non-uniformly sampled protein NMR data at higher dimensions and optimization by distillation. J Biomol NMR. 2009 Nov; 45(3):283-94. PMID: 19705283.
    Citations: 35     Fields:    
  92. Hiller S, Arthanari H, Wagner G. The T-lock: automated compensation of radio-frequency induced sample heating. J Biomol NMR. 2009 Jun; 44(2):69-76. PMID: 19434373.
    Citations: 4     Fields:    
  93. Thakur JK, Arthanari H, Yang F, Chau KH, Wagner G, Näär AM. Mediator subunit Gal11p/MED15 is required for fatty acid-dependent gene activation by yeast transcription factor Oaf1p. J Biol Chem. 2009 Feb 13; 284(7):4422-8. PMID: 19056732.
    Citations: 55     Fields:    Translation:AnimalsCells
  94. Frueh DP, Arthanari H, Koglin A, Vosburg DA, Bennett AE, Walsh CT, Wagner G. Dynamic thiolation-thioesterase structure of a non-ribosomal peptide synthetase. Nature. 2008 Aug 14; 454(7206):903-6. PMID: 18704088.
    Citations: 65     Fields:    Translation:Cells
  95. Arthanari H, Frueh D, Wagner G, Pryor B, Khaneja N. Fourier synthesis techniques for NMR spectroscopy in inhomogeneous fields. J Chem Phys. 2008 Jun 07; 128(21):214503. PMID: 18537429.
    Citations:    Fields:    
  96. Thakur JK, Arthanari H, Yang F, Pan SJ, Fan X, Breger J, Frueh DP, Gulshan K, Li DK, Mylonakis E, Struhl K, Moye-Rowley WS, Cormack BP, Wagner G, Näär AM. A nuclear receptor-like pathway regulating multidrug resistance in fungi. Nature. 2008 Apr 03; 452(7187):604-9. PMID: 18385733.
    Citations: 156     Fields:    Translation:AnimalsCells
  97. Zhong W, Dixit SB, Mallis RJ, Arthanari H, Lugovskoy AA, Beveridge DL, Wagner G, Reinherz EL. CTL recognition of a protective immunodominant influenza A virus nucleoprotein epitope utilizes a highly restricted Vbeta but diverse Valpha repertoire: functional and structural implications. J Mol Biol. 2007 Sep 14; 372(2):535-48. PMID: 17658550.
    Citations: 14     Fields:    Translation:AnimalsCells
  98. Frueh DP, Arthanari H, Wagner G. Unambiguous assignment of NMR protein backbone signals with a time-shared triple-resonance experiment. J Biomol NMR. 2005 Nov; 33(3):187-96. PMID: 16331423.
    Citations: 14     Fields:    Translation:Cells
  99. Natarajan A, Guo Y, Arthanari H, Wagner G, Halperin JA, Chorev M. Synthetic studies toward aryl-(4-aryl-4H-[1,2,4]triazole-3-yl)-amine from 1,3-diarylthiourea as urea mimetics. J Org Chem. 2005 Aug 05; 70(16):6362-8. PMID: 16050698; PMCID: PMC3258527.
    Citations: 4     Fields:    Translation:Cells
  100. Arthanari H, Wojtuszewski K, Mukerji I, Bolton PH. Effects of HU binding on the equilibrium cyclization of mismatched, curved, and normal DNA. Biophys J. 2004 Mar; 86(3):1625-31. PMID: 14990489; PMCID: PMC1303997.
    Citations: 4     Fields:    Translation:Cells
  101. Arthanari H, Bolton PH. Did quadruplex DNA play a role in the evolution of the eukaryotic linear chromosome? Mini Rev Med Chem. 2003 Feb; 3(1):1-9. PMID: 12570850.
    Citations: 4     Fields:    Translation:Cells
  102. Arthanari H, McConnell KJ, Beger R, Young MA, Beveridge DL, Bolton PH. Assessment of the molecular dynamics structure of DNA in solution based on calculated and observed NMR NOESY volumes and dihedral angles from scalar coupling constants. Biopolymers. 2003 Jan; 68(1):3-15. PMID: 12579576.
    Citations: 15     Fields:    Translation:Cells
  103. Arthanari H, Bolton PH. Functional and dysfunctional roles of quadruplex DNA in cells. Chem Biol. 2001 Mar; 8(3):221-30. PMID: 11306347.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  104. Marathias VM, Jerkovic B, Arthanari H, Bolton PH. Flexibility and curvature of duplex DNA containing mismatched sites as a function of temperature. Biochemistry. 2000 Jan 11; 39(1):153-60. PMID: 10625490.
    Citations: 3     Fields:    Translation:Cells
  105. Arthanari H, Bolton PH. Porphyrins can catalyze the interconversion of DNA quadruplex structural types. Anticancer Drug Des. 1999 Aug; 14(4):317-26. PMID: 10625924.
    Citations: 13     Fields:    Translation:Cells
  106. Arthanari H, Basu S, Kawano TL, Bolton PH. Fluorescent dyes specific for quadruplex DNA. Nucleic Acids Res. 1998 Aug 15; 26(16):3724-8. PMID: 9685488; PMCID: PMC147777.
    Citations: 61     Fields:    Translation:AnimalsCells
  107. Beger RD, Arthanari HB, Basu S, Bolton PH. Interresidue quiet NOEs for DNA structural studies. J Magn Reson. 1998 May; 132(1):34-40. PMID: 9615411.
    Citations:    Fields:    Translation:Cells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.