Harvard Catalyst Profiles

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Michael Demian Blower, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01GM122893 (BLOWER, MICHAEL DEMIAN) Sep 1, 2017 - Aug 31, 2019
    Transcriptome regulation during mitosis
    Role: Principal Investigator
  2. R01GM108548 (BLOWER, MICHAEL DEMIAN) Jul 15, 2014 - Feb 28, 2018
    Genome-wide analysis of polyadenylation and translation in Xenopus
    Role: Principal Investigator
  3. R01GM086434 (BLOWER, MICHAEL DEMIAN) Jan 1, 2009 - Nov 30, 2013
    Analysis of microtubule localized RNAs
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Perea-Resa C, Bury L, Cheeseman IM, Blower MD. Cohesin Removal Reprograms Gene Expression upon Mitotic Entry. Mol Cell. 2020 Apr 02; 78(1):127-140.e7. PMID: 32035037.
  2. Yang F, Wang W, Cetinbas M, Sadreyev RI, Blower MD. Genome-wide analysis identifies cis-acting elements regulating mRNA polyadenylation and translation during vertebrate oocyte maturation. RNA. 2020 Mar; 26(3):324-344. PMID: 31896558.
  3. Perea-Resa C, Blower MD. Centromere Biology: Transcription Goes on Stage. Mol Cell Biol. 2018 09 15; 38(18). PMID: 29941491.
    Citations:    Fields:    
  4. Emerman AB, Blower MD. The RNA-binding complex ESCRT-II in Xenopus laevis eggs recognizes purine-rich sequences through its subunit, Vps25. J Biol Chem. 2018 08 10; 293(32):12593-12605. PMID: 29903915.
    Citations:    Fields:    
  5. Perea-Resa C, Blower MD. Satellite Transcripts Locally Promote Centromere Formation. Dev Cell. 2017 08 07; 42(3):201-202. PMID: 28787584.
    Citations: 1     Fields:    Translation:HumansCells
  6. Nadarajan S, Lambert TJ, Altendorfer E, Gao J, Blower MD, Waters JC, Colaiácovo MP. Polo-like kinase-dependent phosphorylation of the synaptonemal complex protein SYP-4 regulates double-strand break formation through a negative feedback loop. Elife. 2017 03 27; 6. PMID: 28346135.
    Citations: 6     Fields:    Translation:AnimalsCells
  7. Toombs JA, Sytnikova YA, Chirn GW, Ang I, Lau NC, Blower MD. Xenopus Piwi proteins interact with a broad proportion of the oocyte transcriptome. RNA. 2017 04; 23(4):504-520. PMID: 28031481.
    Citations: 3     Fields:    Translation:AnimalsCells
  8. Blower MD. Centromeric Transcription Regulates Aurora-B Localization and Activation. Cell Rep. 2016 05 24; 15(8):1624-33. PMID: 27184843.
    Citations: 13     Fields:    Translation:AnimalsCells
  9. Konopacki FA, Wong HH, Dwivedy A, Bellon A, Blower MD, Holt CE. ESCRT-II controls retinal axon growth by regulating DCC receptor levels and local protein synthesis. Open Biol. 2016 Apr; 6(4):150218. PMID: 27248654.
    Citations: 5     Fields:    Translation:AnimalsCells
  10. Nadarajan S, Mohideen F, Tzur YB, Ferrandiz N, Crawley O, Montoya A, Faull P, Snijders AP, Cutillas PR, Jambhekar A, Blower MD, Martinez-Perez E, Harper JW, Colaiacovo MP. The MAP kinase pathway coordinates crossover designation with disassembly of synaptonemal complex proteins during meiosis. Elife. 2016 Feb 27; 5:e12039. PMID: 26920220.
    Citations: 3     Fields:    Translation:AnimalsCells
  11. Emerman AB, Jambhekar A, Blower MD. Identification and Characterization of Mitotic Spindle-Localized Transcripts. Methods Mol Biol. 2016; 1413:303-24. PMID: 27193857.
    Citations:    Fields:    Translation:AnimalsCells
  12. Schwarz DS, Blower MD. The endoplasmic reticulum: structure, function and response to cellular signaling. Cell Mol Life Sci. 2016 Jan; 73(1):79-94. PMID: 26433683.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  13. Schweidenback CT, Emerman AB, Jambhekar A, Blower MD. Evidence for multiple, distinct ADAR-containing complexes in Xenopus laevis. RNA. 2015 Feb; 21(2):279-95. PMID: 25519486.
    Citations:    Fields:    Translation:AnimalsCells
  14. Schwarz DS, Blower MD. The calcium-dependent ribonuclease XendoU promotes ER network formation through local RNA degradation. J Cell Biol. 2014 Oct 13; 207(1):41-57. PMID: 25287301.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  15. Jambhekar A, Emerman AB, Schweidenback CT, Blower MD. RNA stimulates Aurora B kinase activity during mitosis. PLoS One. 2014; 9(6):e100748. PMID: 24968351.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  16. Kovács-Bogdán E, Sancak Y, Kamer KJ, Plovanich M, Jambhekar A, Huber RJ, Myre MA, Blower MD, Mootha VK. Reconstitution of the mitochondrial calcium uniporter in yeast. Proc Natl Acad Sci U S A. 2014 Jun 17; 111(24):8985-90. PMID: 24889638.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  17. Blower MD, Jambhekar A, Schwarz DS, Toombs JA. Combining different mRNA capture methods to analyze the transcriptome: analysis of the Xenopus laevis transcriptome. PLoS One. 2013; 8(10):e77700. PMID: 24143257.
    Citations: 3     Fields:    Translation:Animals
  18. Blower MD. Molecular insights into intracellular RNA localization. Int Rev Cell Mol Biol. 2013; 302:1-39. PMID: 23351709.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  19. Sharp JA, Plant JJ, Ohsumi TK, Borowsky M, Blower MD. Functional analysis of the microtubule-interacting transcriptome. Mol Biol Cell. 2011 Nov; 22(22):4312-23. PMID: 21937723.
    Citations: 18     Fields:    Translation:AnimalsCells
  20. Dai N, Rapley J, Angel M, Yanik MF, Blower MD, Avruch J. mTOR phosphorylates IMP2 to promote IGF2 mRNA translation by internal ribosomal entry. Genes Dev. 2011 Jun 01; 25(11):1159-72. PMID: 21576258.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  21. Robine N, Lau NC, Balla S, Jin Z, Okamura K, Kuramochi-Miyagawa S, Blower MD, Lai EC. A broadly conserved pathway generates 3'UTR-directed primary piRNAs. Curr Biol. 2009 Dec 29; 19(24):2066-76. PMID: 20022248.
    Citations: 107     Fields:    Translation:Animals
  22. Lau NC, Ohsumi T, Borowsky M, Kingston RE, Blower MD. Systematic and single cell analysis of Xenopus Piwi-interacting RNAs and Xiwi. EMBO J. 2009 Oct 07; 28(19):2945-58. PMID: 19713941.
    Citations: 32     Fields:    Translation:AnimalsCells
  23. Blower MD, Feric E, Weis K, Heald R. Genome-wide analysis demonstrates conserved localization of messenger RNAs to mitotic microtubules. J Cell Biol. 2007 Dec 31; 179(7):1365-73. PMID: 18166649.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  24. Brown KS, Blower MD, Maresca TJ, Grammer TC, Harland RM, Heald R. Xenopus tropicalis egg extracts provide insight into scaling of the mitotic spindle. J Cell Biol. 2007 Mar 12; 176(6):765-70. PMID: 17339377.
    Citations: 40     Fields:    Translation:AnimalsCells
  25. Blower MD, Daigle T, Kaufman T, Karpen GH. Drosophila CENP-A mutations cause a BubR1-dependent early mitotic delay without normal localization of kinetochore components. PLoS Genet. 2006 Jul; 2(7):e110. PMID: 16839185.
    Citations: 21     Fields:    Translation:AnimalsCells
  26. Heun P, Erhardt S, Blower MD, Weiss S, Skora AD, Karpen GH. Mislocalization of the Drosophila centromere-specific histone CID promotes formation of functional ectopic kinetochores. Dev Cell. 2006 Mar; 10(3):303-15. PMID: 16516834.
    Citations: 135     Fields:    Translation:AnimalsCells
  27. Blower MD, Nachury M, Heald R, Weis K. A Rae1-containing ribonucleoprotein complex is required for mitotic spindle assembly. Cell. 2005 Apr 22; 121(2):223-34. PMID: 15851029.
    Citations: 127     Fields:    Translation:HumansAnimalsCells
  28. Fyodorov DV, Blower MD, Karpen GH, Kadonaga JT. Acf1 confers unique activities to ACF/CHRAC and promotes the formation rather than disruption of chromatin in vivo. Genes Dev. 2004 Jan 15; 18(2):170-83. PMID: 14752009.
    Citations: 76     Fields:    Translation:AnimalsCells
  29. Blower MD, Sullivan BA, Karpen GH. Conserved organization of centromeric chromatin in flies and humans. Dev Cell. 2002 Mar; 2(3):319-30. PMID: 11879637.
    Citations: 227     Fields:    Translation:HumansAnimalsCells
  30. Blower MD, Karpen GH. The role of Drosophila CID in kinetochore formation, cell-cycle progression and heterochromatin interactions. Nat Cell Biol. 2001 Aug; 3(8):730-9. PMID: 11483958.
    Citations: 142     Fields:    Translation:AnimalsCells
  31. Sullivan BA, Blower MD, Karpen GH. Determining centromere identity: cyclical stories and forking paths. Nat Rev Genet. 2001 Aug; 2(8):584-96. PMID: 11483983.
    Citations: 119     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.