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Darshini Kuruppu, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Kuruppu D, Bhere D, Farrar CT, Shah K, Brownell AL, Mahmood UMU, Tanabe KK. Oncolytic HSV1 targets different growth phases of breast cancer leptomeningeal metastases. Cancer Gene Ther. 2023 Feb 01. PMID: 36721067.
    Citations:    Fields:    
  2. Mody M, Petibon Y, Han P, Kuruppu D, Ma C, Yokell D, Neelamegam R, Normandin MD, Fakhri GE, Brownell AL. In vivo imaging of mGlu5 receptor expression in humans with Fragile X Syndrome towards development of a potential biomarker. Sci Rep. 2021 08 05; 11(1):15897. PMID: 34354107; PMCID: PMC8342610.
    Citations: 6     Fields:    Translation:Humans
  3. Kuruppu D, Bhere D, Farrar CT, Shah K, Brownell AL, Tanabe KK. A model of breast cancer meningeal metastases: characterization with in vivo molecular imaging. Cancer Gene Ther. 2019 05; 26(5-6):145-156. PMID: 30420717.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  4. Brownell AL, Kuruppu D, Kil KE, Jokivarsi K, Poutiainen P, Zhu A, Maxwell M. PET imaging studies show enhanced expression of mGluR5 and inflammatory response during progressive degeneration in ALS mouse model expressing SOD1-G93A gene. J Neuroinflammation. 2015 Nov 24; 12:217. PMID: 26597638.
    Citations: 9     Fields:    Translation:HumansAnimals
  5. Jenkins BG, Zhu A, Poutiainen P, Choi JK, Kil KE, Zhang Z, Kuruppu D, Aytan N, Dedeoglu A, Brownell AL. Functional modulation of G-protein coupled receptors during Parkinson disease-like neurodegeneration. Neuropharmacology. 2016 09; 108:462-73. PMID: 26581500.
    Citations: 1     Fields:    Translation:AnimalsCells
  6. Kil KE, Poutiainen P, Zhang Z, Zhu A, Kuruppu D, Prabhakar S, Choi JK, Tannous BA, Brownell AL. Synthesis and evaluation of N-(methylthiophenyl)picolinamide derivatives as PET radioligands for metabotropic glutamate receptor subtype 4. Bioorg Med Chem Lett. 2016 Jan 01; 26(1):133-9. PMID: 26602273; PMCID: PMC4684791.
    Citations: 4     Fields:    Translation:AnimalsCells
  7. Kuruppu D, Tanabe KK. HSV-1 as a novel therapy for breast cancer meningeal metastases. Cancer Gene Ther. 2015 Oct; 22(10):506-8. PMID: 26384139; PMCID: PMC4766812.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  8. Poutiainen P, Kil KE, Zhang Z, Kuruppu D, Tannous B, Brownell AL. Co-operative binding assay for the characterization of mGlu4 allosteric modulators. Neuropharmacology. 2015 Oct; 97:142-8. PMID: 26025660.
    Citations: 4     Fields:    Translation:AnimalsCells
  9. Kuruppu D, Brownell AL, Shah K, Mahmood U, Tanabe KK. Molecular imaging with bioluminescence and PET reveals viral oncolysis kinetics and tumor viability. Cancer Res. 2014 Aug 01; 74(15):4111-21. PMID: 24876106.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  10. Guo Y, Yuan H, Cho H, Kuruppu D, Jokivarsi K, Agarwal A, Shah K, Josephson L. High efficiency diffusion molecular retention tumor targeting. PLoS One. 2013; 8(3):e58290. PMID: 23505478.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  11. Habibollahi P, van den Berg NS, Kuruppu D, Loda M, Mahmood U. Metformin--an adjunct antineoplastic therapy--divergently modulates tumor metabolism and proliferation, interfering with early response prediction by 18F-FDG PET imaging. J Nucl Med. 2013 Feb; 54(2):252-8. PMID: 23376854.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  12. Kulu Y, Kawasaki H, Donahue JM, Kasuya H, Cusack JC, Choi EW, Kuruppu DK, Fuchs BC, Tanabe KK. Concurrent chemotherapy inhibits herpes simplex virus-1 replication and oncolysis. Cancer Gene Ther. 2013 Feb; 20(2):133-40. PMID: 23348635.
    Citations: 12     Fields:    Translation:HumansCells
  13. Goodwin JM, Schmitt AD, McGinn CM, Fuchs BC, Kuruppu D, Tanabe KK, Lanuti M. Angiogenesis inhibition using an oncolytic herpes simplex virus expressing endostatin in a murine lung cancer model. Cancer Invest. 2012 Mar; 30(3):243-50. PMID: 22360364.
    Citations: 8     Fields:    Translation:AnimalsCells
  14. Wang JQ, Zhang Z, Kuruppu D, Brownell AL. Radiosynthesis of PET radiotracer as a prodrug for imaging group II metabotropic glutamate receptors in vivo. Bioorg Med Chem Lett. 2012 Mar 01; 22(5):1958-62. PMID: 22318160.
    Citations: 6     Fields:    Translation:AnimalsCells
  15. Lee YJ, Koch M, Karl D, Torres-Collado AX, Fernando NT, Rothrock C, Kuruppu D, Ryeom S, Iruela-Arispe ML, Yoon SS. Variable inhibition of thrombospondin 1 against liver and lung metastases through differential activation of metalloproteinase ADAMTS1. Cancer Res. 2010 Feb 01; 70(3):948-56. PMID: 20103648.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  16. Bakirtzi K, Belfort G, Lopez-Coviella I, Kuruppu D, Cao L, Abel ED, Brownell AL, Kandror KV. Cerebellar neurons possess a vesicular compartment structurally and functionally similar to Glut4-storage vesicles from peripheral insulin-sensitive tissues. J Neurosci. 2009 Apr 22; 29(16):5193-201. PMID: 19386915.
    Citations: 26     Fields:    Translation:AnimalsCells
  17. Kulu Y, Dorfman JD, Kuruppu D, Fuchs BC, Goodwin JM, Fujii T, Kuroda T, Lanuti M, Tanabe KK. Comparison of intravenous versus intraperitoneal administration of oncolytic herpes simplex virus 1 for peritoneal carcinomatosis in mice. Cancer Gene Ther. 2009 Apr; 16(4):291-7. PMID: 18989355; PMCID: PMC2657185.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  18. Raher MJ, Thibault HB, Buys ES, Kuruppu D, Shimizu N, Brownell AL, Blake SL, Rieusset J, Kaneki M, Derumeaux G, Picard MH, Bloch KD, Scherrer-Crosbie M. A short duration of high-fat diet induces insulin resistance and predisposes to adverse left ventricular remodeling after pressure overload. Am J Physiol Heart Circ Physiol. 2008 Dec; 295(6):H2495-502. PMID: 18978196; PMCID: PMC2614531.
    Citations: 36     Fields:    Translation:Animals
  19. Sanchez-Pernaute R, Wang JQ, Kuruppu D, Cao L, Tueckmantel W, Kozikowski A, Isacson O, Brownell AL. Enhanced binding of metabotropic glutamate receptor type 5 (mGluR5) PET tracers in the brain of parkinsonian primates. Neuroimage. 2008 Aug 01; 42(1):248-51. PMID: 18501638.
    Citations: 20     Fields:    Translation:AnimalsCells
  20. Tanabe KK, Lemoine A, Finkelstein DM, Kawasaki H, Fujii T, Chung RT, Lauwers GY, Kulu Y, Muzikansky A, Kuruppu D, Lanuti M, Goodwin JM, Azoulay D, Fuchs BC. Epidermal growth factor gene functional polymorphism and the risk of hepatocellular carcinoma in patients with cirrhosis. JAMA. 2008 Jan 02; 299(1):53-60. PMID: 18167406.
    Citations: 89     Fields:    Translation:HumansCells
  21. Kuruppu D, Brownell AL, Zhu A, Yu M, Wang X, Kulu Y, Fuchs BC, Kawasaki H, Tanabe KK. Positron emission tomography of herpes simplex virus 1 oncolysis. Cancer Res. 2007 Apr 01; 67(7):3295-300. PMID: 17409438.
    Citations: 19     Fields:    Translation:AnimalsCells
  22. Kuruppu D, Dorfman JD, Tanabe KK. HSV-1 viral oncolysis and molecular imaging with PET. Curr Cancer Drug Targets. 2007 Mar; 7(2):175-80. PMID: 17346109.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  23. Kuruppu D, Tanabe KK. Viral oncolysis by herpes simplex virus and other viruses. Cancer Biol Ther. 2005 May; 4(5):524-31. PMID: 15917655.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  24. Kasuya H, Kuruppu DK, Donahue JM, Choi EW, Kawasaki H, Tanabe KK. Mouse models of subcutaneous spleen reservoir for multiple portal venous injections to treat liver malignancies. Cancer Res. 2005 May 01; 65(9):3823-7. PMID: 15867380.
    Citations: 9     Fields:    Translation:AnimalsCells
  25. Kuruppu D, Christophi C, Maeda H, O'Brien PE. Changes in the microvascular architecture of colorectal liver metastases following the administration of SMANCS/lipiodol. J Surg Res. 2002 Mar; 103(1):47-54. PMID: 11855917.
    Citations: 2     Fields:    Translation:Animals
  26. Kuruppu D, Christophi C, Bertram JF, O'Brien PE. Tamoxifen inhibits colorectal cancer metastases in the liver: a study in a murine model. J Gastroenterol Hepatol. 1998 May; 13(5):521-7. PMID: 9641652.
    Citations: 6     Fields:    Translation:AnimalsCells
  27. Kuruppu D, Christophi C, O'Brien PE. Microvascular architecture of hepatic metastases in a mouse model. HPB Surg. 1997; 10(3):149-57; discussion 158. PMID: 9174859.
    Citations: 9     Fields:    Translation:Animals
  28. Kuruppu D, Christophi C, Bertram JF, O'Brien PE. Characterization of an animal model of hepatic metastasis. J Gastroenterol Hepatol. 1996 Jan; 11(1):26-32. PMID: 8672738.
    Citations: 28     Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.