Harvard Catalyst Profiles

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Fei Du, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AG066670 (DU, FEI) May 1, 2020 - Apr 30, 2025
    Effects of Orally Administered Nicotinamide Riboside on Bioenergetic Metabolism, Oxidative Stress and Cognition in Mild Cognitive Impairment and Mild Alzheimer's Dementia
    Role: Principal Investigator
  2. R01MH114982 (DU, FEI) Feb 18, 2019 - Nov 30, 2023
    Molecular Mechanisms and Biomarkers for Disease Progression from Prodrome to Early Psychosis
    Role: Principal Investigator
  3. R21MH114020 (DU, FEI) Aug 18, 2017 - May 31, 2020
    Oxidative Stress in First Episode Schizophrenia Assessed in vivo Using NAD+ and NADH Measurement
    Role: Principal Investigator
  4. R01MH095809 (PIZZAGALLI, DIEGO A) Sep 18, 2012 - Apr 30, 2025
    Early Life Stress and Depression: Molecular and Functional Imaging Approaches
    Role: Co-Principal Investigator
  5. R21MH092704 (DU, FEI) Dec 1, 2010 - Aug 30, 2013
    Novel 31P MRS Approach for Measuring Abnormal Bioenergetics in Schizophrenia
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Chen X, Fan X, Song X, Gardner M, Du F, Öngür D. White Matter Metabolite Relaxation and Diffusion Abnormalities in First-Episode Psychosis: A Longitudinal Study. Schizophr Bull. 2022 05 07; 48(3):712-720. PMID: 34999898; PMCID: PMC9077413.
    Citations:    Fields:    Translation:Humans
  2. Song T, Song X, Zhu C, Patrick R, Skurla M, Santangelo I, Green M, Harper D, Ren B, Forester BP, Öngür D, Du F. Mitochondrial dysfunction, oxidative stress, neuroinflammation, and metabolic alterations in the progression of Alzheimer's disease: A meta-analysis of in vivo magnetic resonance spectroscopy studies. Ageing Res Rev. 2021 12; 72:101503. PMID: 34751136; PMCID: PMC8662951.
    Citations: 6     Fields:    Translation:HumansCells
  3. Ironside M, Moser AD, Holsen LM, Zuo CS, Du F, Perlo S, Richards CE, Duda JM, Chen X, Nickerson LD, Null KE, Nascimento N, Crowley DJ, Misra M, Goldstein JM, Pizzagalli DA. Reductions in rostral anterior cingulate GABA are associated with stress circuitry in females with major depression: a multimodal imaging investigation. Neuropsychopharmacology. 2021 11; 46(12):2188-2196. PMID: 34363015; PMCID: PMC8505659.
    Citations:    Fields:    Translation:Humans
  4. Benway CJ, Liu J, Guo F, Du F, Randell SH, Cho MH, Silverman EK, Zhou X. Chromatin Landscapes of Human Lung Cells Predict Potentially Functional Chronic Obstructive Pulmonary Disease Genome-Wide Association Study Variants. Am J Respir Cell Mol Biol. 2021 07; 65(1):92-102. PMID: 33788674.
    Citations: 1     Fields:    Translation:HumansCells
  5. Merritt K, McGuire PK, Egerton A, Aleman A, Block W, Bloemen OJN, Borgan F, Bustillo JR, Capizzano AA, Coughlin JM, De la Fuente-Sandoval C, Demjaha A, Dempster K, Do KQ, Du F, Falkai P, Galinska-Skok B, Gallinat J, Gasparovic C, Ginestet CE, Goto N, Graff-Guerrero A, Ho BC, Howes OD, Jauhar S, Jeon P, Kato T, Kaufmann CA, Kegeles LS, Keshavan M, Kim SY, Kunugi H, Lauriello J, Liemburg EJ, Mcilwain ME, Modinos G, Mouchlianitis ED, Nakamura J, Nenadic I, Öngür D, Ota M, Palaniyappan L, Pantelis C, Plitman E, Posporelis S, Purdon SE, Reichenbach JR, Renshaw PF, Russell BR, Sawa A, Schaefer M, Shungu DC, Smesny S, Stanley JA, Stone JM, Szulc A, Taylor R, Thakkar K, Théberge J, Tibbo PG, van Amelsvoort T, Walecki J, Williamson PC, Wood SJ, Xin L, Yamasue H. Association of Age, Antipsychotic Medication, and Symptom Severity in Schizophrenia With Proton Magnetic Resonance Spectroscopy Brain Glutamate Level: A Mega-analysis of Individual Participant-Level Data. JAMA Psychiatry. 2021 06 01; 78(6):667-681. PMID: 33881460; PMCID: PMC8060889.
    Citations: 15     Fields:    Translation:Humans
  6. Cooper JA, Nuutinen MR, Lawlor VM, DeVries BAM, Barrick EM, Hossein S, Cole DJ, Leonard CV, Hahn EC, Teer AP, Shields GS, Slavich GM, Ongur D, Jensen JE, Du F, Pizzagalli DA, Treadway MT. Reduced adaptation of glutamatergic stress response is associated with pessimistic expectations in depression. Nat Commun. 2021 05 26; 12(1):3166. PMID: 34039978.
    Citations: 1     Fields:    Translation:Humans
  7. Kuan E, Chen X, Du F, Ongur D. N-acetylaspartate concentration in psychotic disorders: T2-relaxation effects. Schizophr Res. 2021 06; 232:42-44. PMID: 34015554; PMCID: PMC8217341.
    Citations: 3     Fields:    Translation:HumansCells
  8. Paris JJ, Chen X, Anderson J, Qrareya AN, Mahdi F, Du F, McLaughlin JP, Kaufman MJ. In vivo proton magnetic resonance spectroscopy detection of metabolite abnormalities in aged Tat-transgenic mouse brain. Geroscience. 2021 08; 43(4):1851-1862. PMID: 33818687; PMCID: PMC8492857.
    Citations: 4     Fields:    Translation:Animals
  9. Yuksel C, Chen X, Chouinard VA, Nickerson LD, Gardner M, Cohen T, Öngür D, Du F. Abnormal Brain Bioenergetics in First-Episode Psychosis. Schizophr Bull Open. 2021 Jan; 2(1):sgaa073. PMID: 33554120; PMCID: PMC7848946.
  10. Whitton AE, Kumar P, Treadway MT, Rutherford AV, Ironside ML, Foti D, Fitzmaurice G, Du F, Pizzagalli DA. Mapping Disease Course Across the Mood Disorder Spectrum Through a Research Domain Criteria Framework. Biol Psychiatry Cogn Neurosci Neuroimaging. 2021 07; 6(7):706-715. PMID: 33508498; PMCID: PMC8273113.
    Citations: 4     Fields:    Translation:Humans
  11. Song X, Chen X, Yuksel C, Yuan J, Pizzagalli DA, Forester B, Öngür D, Du F. Bioenergetics and abnormal functional connectivity in psychotic disorders. Mol Psychiatry. 2021 06; 26(6):2483-2492. PMID: 33398087; PMCID: PMC8254819.
    Citations: 3     Fields:    Translation:Humans
  12. Duda JM, Moser AD, Zuo CS, Du F, Chen X, Perlo S, Richards CE, Nascimento N, Ironside M, Crowley DJ, Holsen LM, Misra M, Hudson JI, Goldstein JM, Pizzagalli DA. Repeatability and reliability of GABA measurements with magnetic resonance spectroscopy in healthy young adults. Magn Reson Med. 2021 05; 85(5):2359-2369. PMID: 33216412; PMCID: PMC7902337.
    Citations: 4     Fields:    Translation:Humans
  13. Hao Y, Bates S, Mou H, Yun JH, Pham B, Liu J, Qiu W, Guo F, Morrow JD, Hersh CP, Benway CJ, Gong L, Zhang Y, Rosas IO, Cho MH, Park JA, Castaldi PJ, Du F, Zhou X. Genome-Wide Association Study: Functional Variant rs2076295 Regulates Desmoplakin Expression in Airway Epithelial Cells. Am J Respir Crit Care Med. 2020 11 01; 202(9):1225-1236. PMID: 32551799; PMCID: PMC7605184.
    Citations: 7     Fields:    Translation:HumansCells
  14. Yuan J, Song X, Kuan E, Wang S, Zuo L, Ongur D, Hu W, Du F. The structural basis for interhemispheric functional connectivity: Evidence from individuals with agenesis of the corpus callosum. Neuroimage Clin. 2020; 28:102425. PMID: 32979843; PMCID: PMC7519397.
    Citations: 4     Fields:    Translation:Humans
  15. Erkol C, Cohen T, Chouinard VA, Lewandowski KE, Du F, Öngür D. White Matter Measures and Cognition in Schizophrenia. Front Psychiatry. 2020; 11:603. PMID: 32765308.
    Citations: 2     
  16. Lewandowski KE, Du F, Fan X, Chen X, Huynh P, Öngür D. Role of glia in prefrontal white matter abnormalities in first episode psychosis or mania detected by diffusion tensor spectroscopy. Schizophr Res. 2019 07; 209:64-71. PMID: 31101514; PMCID: PMC6661189.
    Citations: 4     Fields:    Translation:HumansCells
  17. Chen X, Fan X, Hu Y, Zuo C, Whitfield-Gabrieli S, Holt D, Gong Q, Yang Y, Pizzagalli DA, Du F, Ongur D. Regional GABA Concentrations Modulate Inter-network Resting-state Functional Connectivity. Cereb Cortex. 2019 04 01; 29(4):1607-1618. PMID: 29608677; PMCID: PMC6418388.
    Citations: 14     Fields:    Translation:Humans
  18. Chen X, Tamang SM, Du F, Ongur D. Glutamate diffusion in the rat brain in vivo under light and deep anesthesia conditions. Magn Reson Med. 2019 07; 82(1):84-94. PMID: 30860289.
    Citations: 2     Fields:    Translation:Animals
  19. Castaldi PJ, Guo F, Qiao D, Du F, Naing ZZC, Li Y, Pham B, Mikkelsen TS, Cho MH, Silverman EK, Zhou X. Identification of Functional Variants in the FAM13A Chronic Obstructive Pulmonary Disease Genome-Wide Association Study Locus by Massively Parallel Reporter Assays. Am J Respir Crit Care Med. 2019 01 01; 199(1):52-61. PMID: 30079747; PMCID: PMC6353020.
    Citations: 15     Fields:    Translation:Humans
  20. McPhie DL, Nehme R, Ravichandran C, Babb SM, Ghosh SD, Staskus A, Kalinowski A, Kaur R, Douvaras P, Du F, Ongur D, Fossati V, Eggan K, Cohen BM. Oligodendrocyte differentiation of induced pluripotent stem cells derived from subjects with schizophrenias implicate abnormalities in development. Transl Psychiatry. 2018 10 23; 8(1):230. PMID: 30352993.
    Citations: 17     Fields:    Translation:HumansCells
  21. Dogan AE, Yuksel C, Du F, Chouinard VA, Öngür D. Brain lactate and pH in schizophrenia and bipolar disorder: a systematic review of findings from magnetic resonance studies. Neuropsychopharmacology. 2018 07; 43(8):1681-1690. PMID: 29581538.
    Citations: 20     Fields:    Translation:Humans
  22. Kim SY, Kaufman MJ, Cohen BM, Jensen JE, Coyle JT, Du F, Öngür D. In Vivo Brain Glycine and Glutamate Concentrations in Patients With First-Episode Psychosis Measured by Echo Time-Averaged Proton Magnetic Resonance Spectroscopy at 4T. Biol Psychiatry. 2018 03 15; 83(6):484-491. PMID: 29031411; PMCID: PMC5809251.
    Citations: 8     Fields:    Translation:Humans
  23. Kim SY, Chen W, Ongur D, Du F. Rapid and simultaneous measurement of phosphorus metabolite pool size ratio and reaction kinetics of enzymes in vivo. J Magn Reson Imaging. 2018 01; 47(1):210-221. PMID: 28480619.
    Citations: 4     Fields:    Translation:Animals
  24. Du F, Yuksel C, Chouinard VA, Huynh P, Ryan K, Cohen BM, Öngür D. Abnormalities in High-Energy Phosphate Metabolism in First-Episode Bipolar Disorder Measured Using 31P-Magnetic Resonance Spectroscopy. Biol Psychiatry. 2018 12 01; 84(11):797-802. PMID: 28527566; PMCID: PMC5632123.
    Citations: 14     Fields:    Translation:Humans
  25. Chouinard VA, Kim SY, Valeri L, Yuksel C, Ryan KP, Chouinard G, Cohen BM, Du F, Öngür D. Brain bioenergetics and redox state measured by 31P magnetic resonance spectroscopy in unaffected siblings of patients with psychotic disorders. Schizophr Res. 2017 09; 187:11-16. PMID: 28258794; PMCID: PMC5581291.
    Citations: 13     Fields:    Translation:HumansCells
  26. Kim SY, Cohen BM, Chen X, Lukas SE, Shinn AK, Yuksel AC, Li T, Du F, Öngür D. Redox Dysregulation in Schizophrenia Revealed by in vivo NAD+/NADH Measurement. Schizophr Bull. 2017 01; 43(1):197-204. PMID: 27665001.
    Citations: 34     Fields:    Translation:HumansCells
  27. Li S, Huang X, Li L, Du F, Li J, Bi F, Lui S, Turner JA, Sweeney JA, Gong Q. Posttraumatic Stress Disorder: Structural Characterization with 3-T MR Imaging. Radiology. 2016 08; 280(2):537-44. PMID: 26928229.
    Citations: 12     Fields:    Translation:Humans
  28. Yuksel C, Tegin C, O'Connor L, Du F, Ahat E, Cohen BM, Ongur D. Phosphorus magnetic resonance spectroscopy studies in schizophrenia. J Psychiatr Res. 2015 Sep; 68:157-66. PMID: 26228415.
    Citations: 9     Fields:    Translation:Humans
  29. Lewandowski KE, Ongür D, Sperry SH, Cohen BM, Sehovic S, Goldbach JR, Du F. Myelin vs axon abnormalities in white matter in bipolar disorder. Neuropsychopharmacology. 2015 Mar 13; 40(5):1243-9. PMID: 25409595.
    Citations: 11     Fields:    Translation:HumansCells
  30. Hall MH, Jensen JE, Du F, Smoller JW, O'Connor L, Spencer KM, Öngür D. Frontal P3 event-related potential is related to brain glutamine/glutamate ratio measured in vivo. Neuroimage. 2015 May 01; 111:186-91. PMID: 25687595.
    Citations: 12     Fields:    Translation:Humans
  31. Du F, Cooper AJ, Thida T, Sehovic S, Lukas SE, Cohen BM, Zhang X, Ongür D. In vivo evidence for cerebral bioenergetic abnormalities in schizophrenia measured using 31P magnetization transfer spectroscopy. JAMA Psychiatry. 2014 Jan; 71(1):19-27. PMID: 24196348; PMCID: PMC7461723.
    Citations: 39     Fields:    Translation:Humans
  32. Du F, Ongür D. Probing myelin and axon abnormalities separately in psychiatric disorders using MRI techniques. Front Integr Neurosci. 2013; 7:24. PMID: 23596402.
    Citations: 15     
  33. Du F, Cooper AJ, Thida T, Shinn AK, Cohen BM, Ongür D. Myelin and axon abnormalities in schizophrenia measured with magnetic resonance imaging techniques. Biol Psychiatry. 2013 Sep 15; 74(6):451-7. PMID: 23571010.
    Citations: 44     Fields:    Translation:HumansCells
  34. Du F, Cooper A, Lukas SE, Cohen BM, Ongür D. Creatine kinase and ATP synthase reaction rates in human frontal lobe measured by ³¹P magnetization transfer spectroscopy at 4T. Magn Reson Imaging. 2013 Jan; 31(1):102-8. PMID: 22898695.
    Citations: 13     Fields:    Translation:HumansCells
  35. Du F, Zhang Y, Zhu XH, Chen W. Simultaneous measurement of glucose blood-brain transport constants and metabolic rate in rat brain using in-vivo 1H MRS. J Cereb Blood Flow Metab. 2012 Sep; 32(9):1778-87. PMID: 22714049.
    Citations: 4     Fields:    Translation:Animals
  36. Du F, Zhang Y, Chen W. Relayed magnetization transfer from nuclear Overhauser effect and chemical exchange observed by in vivo ³¹P MRS in rat brain. Magn Reson Imaging. 2012 Jun; 30(5):716-21. PMID: 22459438.
    Citations: 6     Fields:    Translation:Animals
  37. Forester BP, Zuo CS, Ravichandran C, Harper DG, Du F, Kim S, Cohen BM, Renshaw PF. Coenzyme Q10 effects on creatine kinase activity and mood in geriatric bipolar depression. J Geriatr Psychiatry Neurol. 2012 Mar; 25(1):43-50. PMID: 22467846.
    Citations: 19     Fields:    Translation:HumansCTClinical Trials
  38. Du F, Cooper A, Cohen BM, Renshaw PF, Öngür D. Water and metabolite transverse T2 relaxation time abnormalities in the white matter in schizophrenia. Schizophr Res. 2012 May; 137(1-3):241-5. PMID: 22356802.
    Citations: 15     Fields:    Translation:HumansCells
  39. Zhu XH, Qiao H, Du F, Xiong Q, Liu X, Zhang X, Ugurbil K, Chen W. Quantitative imaging of energy expenditure in human brain. Neuroimage. 2012 May 01; 60(4):2107-17. PMID: 22487547.
    Citations: 87     Fields:    Translation:Humans
  40. Xiong Q, Du F, Zhu X, Zhang P, Suntharalingam P, Ippolito J, Kamdar FD, Chen W, Zhang J. ATP production rate via creatine kinase or ATP synthase in vivo: a novel superfast magnetization saturation transfer method. Circ Res. 2011 Mar 18; 108(6):653-63. PMID: 21293002.
    Citations: 38     Fields:    Translation:Animals
  41. Du F, Zhang Y, Iltis I, Marjanska M, Zhu XH, Henry PG, Chen W. In vivo proton MRS to quantify anesthetic effects of pentobarbital on cerebral metabolism and brain activity in rat. Magn Reson Med. 2009 Dec; 62(6):1385-93. PMID: 19780161.
    Citations: 19     Fields:    Translation:Animals
  42. Xiong Q, Li Q, Mansoor A, Jameel MN, Du F, Chen W, Zhang J. Novel strategy for measuring creatine kinase reaction rate in the in vivo heart. Am J Physiol Heart Circ Physiol. 2009 Sep; 297(3):H1010-9. PMID: 19561307.
    Citations: 13     Fields:    Translation:Animals
  43. Zhu XH, Du F, Zhang N, Zhang Y, Lei H, Zhang X, Qiao H, Ugurbil K, Chen W. Advanced In Vivo Heteronuclear MRS Approaches for Studying Brain Bioenergetics Driven by Mitochondria. Methods Mol Biol. 2009; 489:317-57. PMID: 18839099.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  44. Du F, Zhu XH, Zhang Y, Friedman M, Zhang N, Ugurbil K, Chen W. Tightly coupled brain activity and cerebral ATP metabolic rate. Proc Natl Acad Sci U S A. 2008 Apr 29; 105(17):6409-14. PMID: 18443293; PMCID: PMC2359810.
    Citations: 103     Fields:    Translation:Animals
  45. Iltis I, Marjanska M, Du F, Koski DM, Zhu XH, Ugurbil K, Chen W, Henry PG. (1)H MRS in the rat brain under pentobarbital anesthesia: accurate quantification of in vivo spectra in the presence of propylene glycol. Magn Reson Med. 2008 Mar; 59(3):631-5. PMID: 18224694.
    Citations: 3     Fields:    Translation:Animals
  46. Du F, Zhu XH, Qiao H, Zhang X, Chen W. Efficient in vivo 31P magnetization transfer approach for noninvasively determining multiple kinetic parameters and metabolic fluxes of ATP metabolism in the human brain. Magn Reson Med. 2007 Jan; 57(1):103-14. PMID: 17191226.
    Citations: 61     Fields:    Translation:Humans
  47. Qiao H, Zhang X, Zhu XH, Du F, Chen W. In vivo 31P MRS of human brain at high/ultrahigh fields: a quantitative comparison of NMR detection sensitivity and spectral resolution between 4 T and 7 T. Magn Reson Imaging. 2006 Dec; 24(10):1281-6. PMID: 17145398.
    Citations: 29     Fields:    Translation:Humans
  48. Du F, Chu WJ, Yang B, Den Hollander JA, Ng TC. In vivo GABA detection with improved selectivity and sensitivity by localized double quantum filter technique at 4.1T. Magn Reson Imaging. 2004 Jan; 22(1):103-8. PMID: 14972399.
    Citations: 3     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.