Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Brendan D. Manning, Ph.D.

Co-Author

This page shows the publications co-authored by Brendan Manning and John Asara.
Connection Strength

2.586
  1. Hepatic mTORC1 signaling activates ATF4 as part of its metabolic response to feeding and insulin. Mol Metab. 2021 Nov; 53:101309.
    View in: PubMed
    Score: 0.244
  2. The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals. Elife. 2021 Mar 01; 10.
    View in: PubMed
    Score: 0.238
  3. IMPDH inhibitors for antitumor therapy in tuberous sclerosis complex. JCI Insight. 2020 04 09; 5(7).
    View in: PubMed
    Score: 0.223
  4. Direct stimulation of NADP+ synthesis through Akt-mediated phosphorylation of NAD kinase. Science. 2019 03 08; 363(6431):1088-1092.
    View in: PubMed
    Score: 0.207
  5. Ex vivo and in vivo stable isotope labelling of central carbon metabolism and related pathways with analysis by LC-MS/MS. Nat Protoc. 2019 02; 14(2):313-330.
    View in: PubMed
    Score: 0.206
  6. The mTORC1 Signaling Network Senses Changes in Cellular Purine Nucleotide Levels. Cell Rep. 2017 Oct 31; 21(5):1331-1346.
    View in: PubMed
    Score: 0.189
  7. mTORC1 Couples Nucleotide Synthesis to Nucleotide Demand Resulting in a Targetable Metabolic Vulnerability. Cancer Cell. 2017 11 13; 32(5):624-638.e5.
    View in: PubMed
    Score: 0.188
  8. A relative quantitative positive/negative ion switching method for untargeted lipidomics via high resolution LC-MS/MS from any biological source. Metabolomics. 2017 Mar; 13(3).
    View in: PubMed
    Score: 0.179
  9. Sterol Regulatory Element Binding Protein Regulates the Expression and Metabolic Functions of Wild-Type and Oncogenic IDH1. Mol Cell Biol. 2016 09 15; 36(18):2384-95.
    View in: PubMed
    Score: 0.174
  10. mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle. Science. 2016 Feb 12; 351(6274):728-733.
    View in: PubMed
    Score: 0.167
  11. Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1. Science. 2013 Mar 15; 339(6125):1323-8.
    View in: PubMed
    Score: 0.136
  12. TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1. Mol Cell. 2012 Aug 24; 47(4):535-46.
    View in: PubMed
    Score: 0.131
  13. Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1. Mol Cell Biol. 2009 Nov; 29(21):5657-70.
    View in: PubMed
    Score: 0.107
  14. Author Correction: Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis. Nat Cell Biol. 2019 05; 21(5):662-663.
    View in: PubMed
    Score: 0.052
  15. ZBTB7A acts as a tumor suppressor through the transcriptional repression of glycolysis. Genes Dev. 2014 Sep 01; 28(17):1917-28.
    View in: PubMed
    Score: 0.038
  16. Low-dose radiation exposure induces a HIF-1-mediated adaptive and protective metabolic response. Cell Death Differ. 2014 May; 21(5):836-44.
    View in: PubMed
    Score: 0.037
  17. Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis. Nat Cell Biol. 2013 Nov; 15(11):1340-50.
    View in: PubMed
    Score: 0.036
  18. Metabolic and functional genomic studies identify deoxythymidylate kinase as a target in LKB1-mutant lung cancer. Cancer Discov. 2013 Aug; 3(8):870-9.
    View in: PubMed
    Score: 0.035
Connection Strength
The connection strength for co-authors is the sum of the scores for each of their shared publications.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.