Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Brendan D. Manning, Ph.D.

Co-Author

This page shows the publications co-authored by Brendan Manning and David Kwiatkowski.
Connection Strength

1.951
  1. Molecular basis of giant cells in tuberous sclerosis complex. N Engl J Med. 2014 Aug 21; 371(8):778-80.
    View in: PubMed
    Score: 0.604
  2. Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways. Hum Mol Genet. 2005 Oct 15; 14 Spec No. 2:R251-8.
    View in: PubMed
    Score: 0.327
  3. mTORC1 Couples Nucleotide Synthesis to Nucleotide Demand Resulting in a Targetable Metabolic Vulnerability. Cancer Cell. 2017 11 13; 32(5):624-638.e5.
    View in: PubMed
    Score: 0.188
  4. Coordinated regulation of protein synthesis and degradation by mTORC1. Nature. 2014 Sep 18; 513(7518):440-3.
    View in: PubMed
    Score: 0.150
  5. TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1. Mol Cell. 2012 Aug 24; 47(4):535-46.
    View in: PubMed
    Score: 0.131
  6. Chronic activation of mTOR complex 1 is sufficient to cause hepatocellular carcinoma in mice. Sci Signal. 2012 Mar 27; 5(217):ra24.
    View in: PubMed
    Score: 0.128
  7. Therapeutic trial of metformin and bortezomib in a mouse model of tuberous sclerosis complex (TSC). PLoS One. 2012; 7(2):e31900.
    View in: PubMed
    Score: 0.127
  8. Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways. Cell Metab. 2011 Jul 06; 14(1):21-32.
    View in: PubMed
    Score: 0.122
  9. Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2. Genes Dev. 2005 Aug 01; 19(15):1773-8.
    View in: PubMed
    Score: 0.080
  10. Advances and Future Directions for Tuberous Sclerosis Complex Research: Recommendations From the 2015 Strategic Planning Conference. Pediatr Neurol. 2016 07; 60:1-12.
    View in: PubMed
    Score: 0.042
  11. Metabolic and functional genomic studies identify deoxythymidylate kinase as a target in LKB1-mutant lung cancer. Cancer Discov. 2013 Aug; 3(8):870-9.
    View in: PubMed
    Score: 0.035
  12. Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling. Proc Natl Acad Sci U S A. 2002 Oct 15; 99(21):13571-6.
    View in: PubMed
    Score: 0.017
Connection Strength
The connection strength for co-authors is the sum of the scores for each of their shared publications.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.