Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Brendan D. Manning, Ph.D.

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Other Positions
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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R35CA197459 (MANNING, BRENDAN D.) Aug 14, 2015 - Jul 31, 2022
    NIH/NCI
    Decoding and targeting the PI3K-mTOR signaling network in cancer
    Role: Principal Investigator
  2. R01CA181390 (MANNING, BRENDAN D.) Jul 1, 2014 - Jun 30, 2019
    NIH/NCI
    Metabolic control of cell growth by the mTOR signaling network
    Role: Principal Investigator
  3. R01CA122617 (MANNING, BRENDAN D.) Jul 13, 2006 - Apr 30, 2020
    NIH/NCI
    Regulatory mechanisms and role of the PI3K-TSC-mTOR signaling network in tumors
    Role: Principal Investigator
  4. P01CA120964 (KWIATKOWSKI, DAVID J.) Apr 1, 2006 - Jul 31, 2023
    NIH/NCI
    Molecular Pathogenesis of the Hamartoma Syndromes
    Role: Co-Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Liu P, Gan W, Inuzuka H, Lazorchak AS, Gao D, Arojo O, Liu D, Wan L, Zhai B, Yu Y, Yuan M, Kim BM, Shaik S, Menon S, Gygi SP, Lee TH, Asara JM, Manning BD, Blenis J, Su B, Wei W. Author Correction: Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis. Nat Cell Biol. 2019 May; 21(5):662-663. PMID: 30783264.
    Citations:    
  2. Hoxhaj G, Ben-Sahra I, Lockwood SE, Timson RC, Byles V, Henning GT, Gao P, Selfors LM, Asara JM, Manning BD. Direct stimulation of NADP+ synthesis through Akt-mediated phosphorylation of NAD kinase. Science. 2019 03 08; 363(6431):1088-1092. PMID: 30846598.
    Citations:    
  3. Manning BD. Signalling protein protects the heart muscle from pressure-related stress. Nature. 2019 Feb; 566(7743):187-188. PMID: 30737501.
    Citations:    
  4. Yuan M, Kremer DM, Huang H, Breitkopf SB, Ben-Sahra I, Manning BD, Lyssiotis CA, Asara JM. Ex vivo and in vivo stable isotope labelling of central carbon metabolism and related pathways with analysis by LC-MS/MS. Nat Protoc. 2019 02; 14(2):313-330. PMID: 30683937.
    Citations:    Fields:    
  5. Hosios AM, Manning BD. Lysosomal catch-and-release controls mTORC1. Nat Cell Biol. 2018 Sep; 20(9):996-997. PMID: 30154562.
    Citations:    Fields:    
  6. Longchamp A, Mirabella T, Arduini A, MacArthur MR, Das A, Treviño-Villarreal JH, Hine C, Ben-Sahra I, Knudsen NH, Brace LE, Reynolds J, Mejia P, Tao M, Sharma G, Wang R, Corpataux JM, Haefliger JA, Ahn KH, Lee CH, Manning BD, Sinclair DA, Chen CS, Ozaki CK, Mitchell JR. Amino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and H2S Production. Cell. 2018 03 22; 173(1):117-129.e14. PMID: 29570992.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  7. Zabala-Letona A, Arruabarrena-Aristorena A, Martín-Martín N, Fernandez-Ruiz S, Sutherland JD, Clasquin M, Tomas-Cortazar J, Jimenez J, Torres I, Quang P, Ximenez-Embun P, Bago R, Ugalde-Olano A, Loizaga-Iriarte A, Lacasa-Viscasillas I, Unda M, Torrano V, Cabrera D, van Liempd SM, Cendon Y, Castro E, Murray S, Revandkar A, Alimonti A, Zhang Y, Barnett A, Lein G, Pirman D, Cortazar AR, Arreal L, Prudkin L, Astobiza I, Valcarcel-Jimenez L, Zuñiga-García P, Fernandez-Dominguez I, Piva M, Caro-Maldonado A, Sánchez-Mosquera P, Castillo-Martín M, Serra V, Beraza N, Gentilella A, Thomas G, Azkargorta M, Elortza F, Farràs R, Olmos D, Efeyan A, Anguita J, Muñoz J, Falcón-Pérez JM, Barrio R, Macarulla T, Mato JM, Martinez-Chantar ML, Cordon-Cardo C, Aransay AM, Marks K, Baselga J, Tabernero J, Nuciforo P, Manning BD, Marjon K, Carracedo A. Corrigendum: mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer. Nature. 2018 02 22; 554(7693):554. PMID: 29342137.
    Citations:    Fields:    
  8. Housden BE, Li Z, Kelley C, Wang Y, Hu Y, Valvezan AJ, Manning BD, Perrimon N. Improved detection of synthetic lethal interactions in Drosophila cells using variable dose analysis (VDA). Proc Natl Acad Sci U S A. 2017 12 12; 114(50):E10755-E10762. PMID: 29183982.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  9. Kelsey I, Zbinden M, Byles V, Torrence M, Manning BD. mTORC1 suppresses PIM3 expression via miR-33 encoded by the SREBP loci. Sci Rep. 2017 Nov 23; 7(1):16112. PMID: 29170467.
    Citations:    Fields:    
  10. Hoxhaj G, Hughes-Hallett J, Timson RC, Ilagan E, Yuan M, Asara JM, Ben-Sahra I, Manning BD. The mTORC1 Signaling Network Senses Changes in Cellular Purine Nucleotide Levels. Cell Rep. 2017 Oct 31; 21(5):1331-1346. PMID: 29091770.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  11. Valvezan AJ, Turner M, Belaid A, Lam HC, Miller SK, McNamara MC, Baglini C, Housden BE, Perrimon N, Kwiatkowski DJ, Asara JM, Henske EP, Manning BD. mTORC1 Couples Nucleotide Synthesis to Nucleotide Demand Resulting in a Targetable Metabolic Vulnerability. Cancer Cell. 2017 11 13; 32(5):624-638.e5. PMID: 29056426.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  12. Manning BD. Game of TOR - The Target of Rapamycin Rules Four Kingdoms. N Engl J Med. 2017 Sep 28; 377(13):1297-9. PMID: 28874074.
    Citations: 1     Fields:    Translation:AnimalsCells
  13. Heintz C, Doktor TK, Lanjuin A, Escoubas CC, Zhang Y, Weir HJ, Dutta S, Silva-García CG, Bruun GH, Morantte I, Hoxhaj G, Manning BD, Andresen BS, Mair WB. Corrigendum: Splicing factor 1 modulates dietary restriction and TORC1 pathway longevity in C. elegans. Nature. 2017 07 27; 547(7664):476. PMID: 28700577.
    Citations:    Fields:    
  14. Zabala-Letona A, Arruabarrena-Aristorena A, Martín-Martín N, Fernandez-Ruiz S, Sutherland JD, Clasquin M, Tomas-Cortazar J, Jimenez J, Torres I, Quang P, Ximenez-Embun P, Bago R, Ugalde-Olano A, Loizaga-Iriarte A, Lacasa-Viscasillas I, Unda M, Torrano V, Cabrera D, van Liempd SM, Cendon Y, Castro E, Murray S, Revandkar A, Alimonti A, Zhang Y, Barnett A, Lein G, Pirman D, Cortazar AR, Arreal L, Prudkin L, Astobiza I, Valcarcel-Jimenez L, Zuñiga-García P, Fernandez-Dominguez I, Piva M, Caro-Maldonado A, Sánchez-Mosquera P, Castillo-Martín M, Serra V, Beraza N, Gentilella A, Thomas G, Azkargorta M, Elortza F, Farràs R, Olmos D, Efeyan A, Anguita J, Muñoz J, Falcón-Pérez JM, Barrio R, Macarulla T, Mato JM, Martinez-Chantar ML, Cordon-Cardo C, Aransay AM, Marks K, Baselga J, Tabernero J, Nuciforo P, Manning BD, Marjon K, Carracedo A. mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer. Nature. 2017 07 06; 547(7661):109-113. PMID: 28658205.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  15. Manning BD, Toker A. AKT/PKB Signaling: Navigating the Network. Cell. 2017 04 20; 169(3):381-405. PMID: 28431241.
    Citations: 94     Fields:    Translation:HumansAnimalsCells
  16. Ben-Sahra I, Manning BD. mTORC1 signaling and the metabolic control of cell growth. Curr Opin Cell Biol. 2017 04; 45:72-82. PMID: 28411448.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  17. Breitkopf SB, Ricoult SJH, Yuan M, Xu Y, Peake DA, Manning BD, Asara JM. A relative quantitative positive/negative ion switching method for untargeted lipidomics via high resolution LC-MS/MS from any biological source. Metabolomics. 2017 Mar; 13(3). PMID: 28496395.
    Citations: 3     
  18. Howell JJ, Hellberg K, Turner M, Talbott G, Kolar MJ, Ross DS, Hoxhaj G, Saghatelian A, Shaw RJ, Manning BD. Metformin Inhibits Hepatic mTORC1 Signaling via Dose-Dependent Mechanisms Involving AMPK and the TSC Complex. Cell Metab. 2017 02 07; 25(2):463-471. PMID: 28089566.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  19. Heintz C, Doktor TK, Lanjuin A, Escoubas C, Zhang Y, Weir HJ, Dutta S, Silva-García CG, Bruun GH, Morantte I, Hoxhaj G, Manning BD, Andresen BS, Mair WB. Splicing factor 1 modulates dietary restriction and TORC1 pathway longevity in C. elegans. Nature. 2017 01 05; 541(7635):102-106. PMID: 27919065.
    Citations: 19     Fields:    Translation:AnimalsCells
  20. Ricoult SJ, Dibble CC, Asara JM, Manning BD. Sterol Regulatory Element Binding Protein Regulates the Expression and Metabolic Functions of Wild-Type and Oncogenic IDH1. Mol Cell Biol. 2016 09 15; 36(18):2384-95. PMID: 27354064.
    Citations: 3     Fields:    Translation:HumansCells
  21. Ilagan E, Manning BD. Emerging role of mTOR in the response to cancer therapeutics. Trends Cancer. 2016 May; 2(5):241-251. PMID: 27668290.
    Citations: 21     Fields:    
  22. Sahin M, Henske EP, Manning BD, Ess KC, Bissler JJ, Klann E, Kwiatkowski DJ, Roberds SL, Silva AJ, Hillaire-Clarke CS, Young LR, Zervas M, Mamounas LA. Advances and Future Directions for Tuberous Sclerosis Complex Research: Recommendations From the 2015 Strategic Planning Conference. Pediatr Neurol. 2016 07; 60:1-12. PMID: 27267556.
    Citations: 9     Fields:    Translation:HumansAnimals
  23. Hallett JEH, Manning BD. CASTORing New Light on Amino Acid Sensing. Cell. 2016 Mar 24; 165(1):15-17. PMID: 27015302.
    Citations: 3     Fields:    Translation:Cells
  24. Covarrubias AJ, Aksoylar HI, Yu J, Snyder NW, Worth AJ, Iyer SS, Wang J, Ben-Sahra I, Byles V, Polynne-Stapornkul T, Espinosa EC, Lamming D, Manning BD, Zhang Y, Blair IA, Horng T. Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation. Elife. 2016 Feb 19; 5. PMID: 26894960.
    Citations: 40     Fields:    Translation:AnimalsCells
  25. Ben-Sahra I, Hoxhaj G, Ricoult SJH, Asara JM, Manning BD. mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle. Science. 2016 Feb 12; 351(6274):728-733. PMID: 26912861.
    Citations: 69     Fields:    Translation:HumansAnimalsCells
  26. Zhang Y, Manning BD. Zhang & Manning reply. Nature. 2016 Jan 21; 529(7586):E2-3. PMID: 26791732.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  27. Housden BE, Valvezan AJ, Kelley C, Sopko R, Hu Y, Roesel C, Lin S, Buckner M, Tao R, Yilmazel B, Mohr SE, Manning BD, Perrimon N. Identification of potential drug targets for tuberous sclerosis complex by synthetic screens combining CRISPR-based knockouts with RNAi. Sci Signal. 2015 Sep 08; 8(393):rs9. PMID: 26350902.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  28. Priolo C, Ricoult SJ, Khabibullin D, Filippakis H, Yu J, Manning BD, Clish C, Henske EP. Tuberous sclerosis complex 2 loss increases lysophosphatidylcholine synthesis in lymphangioleiomyomatosis. Am J Respir Cell Mol Biol. 2015 Jul; 53(1):33-41. PMID: 25780943.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  29. Ricoult SJ, Yecies JL, Ben-Sahra I, Manning BD. Oncogenic PI3K and K-Ras stimulate de novo lipid synthesis through mTORC1 and SREBP. Oncogene. 2016 Mar 10; 35(10):1250-60. PMID: 26028026.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  30. Zhang Y, Manning BD. mTORC1 signaling activates NRF1 to increase cellular proteasome levels. Cell Cycle. 2015; 14(13):2011-7. PMID: 26017155.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  31. Dowdle WE, Nyfeler B, Nagel J, Elling RA, Liu S, Triantafellow E, Menon S, Wang Z, Honda A, Pardee G, Cantwell J, Luu C, Cornella-Taracido I, Harrington E, Fekkes P, Lei H, Fang Q, Digan ME, Burdick D, Powers AF, Helliwell SB, D'Aquin S, Bastien J, Wang H, Wiederschain D, Kuerth J, Bergman P, Schwalb D, Thomas J, Ugwonali S, Harbinski F, Tallarico J, Wilson CJ, Myer VE, Porter JA, Bussiere DE, Finan PM, Labow MA, Mao X, Hamann LG, Manning BD, Valdez RA, Nicholson T, Schirle M, Knapp MS, Keaney EP, Murphy LO. Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo. Nat Cell Biol. 2014 Nov; 16(11):1069-79. PMID: 25327288.
    Citations: 86     Fields:    Translation:HumansAnimalsCells
  32. Liu XS, Haines JE, Mehanna EK, Genet MD, Ben-Sahra I, Asara JM, Manning BD, Yuan ZM. ZBTB7A acts as a tumor suppressor through the transcriptional repression of glycolysis. Genes Dev. 2014 Sep 01; 28(17):1917-28. PMID: 25184678.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  33. Kwiatkowski DJ, Manning BD. Molecular basis of giant cells in tuberous sclerosis complex. N Engl J Med. 2014 Aug 21; 371(8):778-80. PMID: 25140966.
    Citations: 12     Fields:    Translation:HumansCells
  34. Harputlugil E, Hine C, Vargas D, Robertson L, Manning BD, Mitchell JR. The TSC complex is required for the benefits of dietary protein restriction on stress resistance in vivo. Cell Rep. 2014 Aug 21; 8(4):1160-70. PMID: 25131199.
    Citations: 20     Fields:    Translation:AnimalsCells
  35. Zhang Y, Nicholatos J, Dreier JR, Ricoult SJ, Widenmaier SB, Hotamisligil GS, Kwiatkowski DJ, Manning BD. Coordinated regulation of protein synthesis and degradation by mTORC1. Nature. 2014 Sep 18; 513(7518):440-3. PMID: 25043031.
    Citations: 67     Fields:    Translation:HumansAnimalsCells
  36. Lall R, Ganapathy S, Yang M, Xiao S, Xu T, Su H, Shadfan M, Asara JM, Ha CS, Ben-Sahra I, Manning BD, Little JB, Yuan ZM. Low-dose radiation exposure induces a HIF-1-mediated adaptive and protective metabolic response. Cell Death Differ. 2014 May; 21(5):836-44. PMID: 24583639.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  37. Menon S, Dibble CC, Talbott G, Hoxhaj G, Valvezan AJ, Takahashi H, Cantley LC, Manning BD. Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome. Cell. 2014 Feb 13; 156(4):771-85. PMID: 24529379.
    Citations: 166     Fields:    Translation:HumansAnimalsCells
  38. Liu P, Gan W, Inuzuka H, Lazorchak AS, Gao D, Arojo O, Liu D, Wan L, Zhai B, Yu Y, Yuan M, Kim BM, Shaik S, Menon S, Gygi SP, Lee TH, Asara JM, Manning BD, Blenis J, Su B, Wei W. Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis. Nat Cell Biol. 2013 Nov; 15(11):1340-50. PMID: 24161930.
    Citations: 76     Fields:    Translation:HumansCells
  39. Kelsey I, Manning BD. mTORC1 status dictates tumor response to targeted therapeutics. Sci Signal. 2013 Sep 24; 6(294):pe31. PMID: 24065143.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  40. Howell JJ, Ricoult SJ, Ben-Sahra I, Manning BD. A growing role for mTOR in promoting anabolic metabolism. Biochem Soc Trans. 2013 Aug; 41(4):906-12. PMID: 23863154.
    Citations: 65     Fields:    Translation:HumansCells
  41. Ersoy BA, Tarun A, D'Aquino K, Hancer NJ, Ukomadu C, White MF, Michel T, Manning BD, Cohen DE. Phosphatidylcholine transfer protein interacts with thioesterase superfamily member 2 to attenuate insulin signaling. Sci Signal. 2013 Jul 30; 6(286):ra64. PMID: 23901139.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  42. Menon S, Manning BD. Cell signalling: nutrient sensing lost in cancer. Nature. 2013 Jun 27; 498(7455):444-5. PMID: 23803840.
    Citations: 4     Fields:    Translation:HumansCells
  43. Manning BD. Adaptation to starvation: translating a matter of life or death. Cancer Cell. 2013 Jun 10; 23(6):713-5. PMID: 23763997.
    Citations:    
  44. Dibble CC, Manning BD. Signal integration by mTORC1 coordinates nutrient input with biosynthetic output. Nat Cell Biol. 2013 Jun; 15(6):555-64. PMID: 23728461.
    Citations: 205     Fields:    Translation:HumansAnimalsCells
  45. Liu Y, Marks K, Cowley GS, Carretero J, Liu Q, Nieland TJ, Xu C, Cohoon TJ, Gao P, Zhang Y, Chen Z, Altabef AB, Tchaicha JH, Wang X, Choe S, Driggers EM, Zhang J, Bailey ST, Sharpless NE, Hayes DN, Patel NM, Janne PA, Bardeesy N, Engelman JA, Manning BD, Shaw RJ, Asara JM, Scully R, Kimmelman A, Byers LA, Gibbons DL, Wistuba II, Heymach JV, Kwiatkowski DJ, Kim WY, Kung AL, Gray NS, Root DE, Cantley LC, Wong KK. Metabolic and functional genomic studies identify deoxythymidylate kinase as a target in LKB1-mutant lung cancer. Cancer Discov. 2013 Aug; 3(8):870-9. PMID: 23715154.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  46. Ben-Sahra I, Howell JJ, Asara JM, Manning BD. Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1. Science. 2013 Mar 15; 339(6125):1323-8. PMID: 23429703.
    Citations: 158     Fields:    Translation:HumansAnimalsCells
  47. Byles V, Covarrubias AJ, Ben-Sahra I, Lamming DW, Sabatini DM, Manning BD, Horng T. The TSC-mTOR pathway regulates macrophage polarization. Nat Commun. 2013; 4:2834. PMID: 24280772.
    Citations: 81     Fields:    Translation:AnimalsCells
  48. Dibble CC, Elis W, Menon S, Qin W, Klekota J, Asara JM, Finan PM, Kwiatkowski DJ, Murphy LO, Manning BD. TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1. Mol Cell. 2012 Aug 24; 47(4):535-46. PMID: 22795129.
    Citations: 146     Fields:    Translation:HumansCells
  49. Manning BD. Comment on "A dynamic network model of mTOR signaling reveals TSC-independent mTORC2 regulation": building a model of the mTOR signaling network with a potentially faulty tool. Sci Signal. 2012 Jul 10; 5(232):lc3; author reply lc4. PMID: 22786721.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  50. Menon S, Yecies JL, Zhang HH, Howell JJ, Nicholatos J, Harputlugil E, Bronson RT, Kwiatkowski DJ, Manning BD. Chronic activation of mTOR complex 1 is sufficient to cause hepatocellular carcinoma in mice. Sci Signal. 2012 Mar 27; 5(217):ra24. PMID: 22457330.
    Citations: 53     Fields:    Translation:AnimalsCells
  51. Auricchio N, Malinowska I, Shaw R, Manning BD, Kwiatkowski DJ. Therapeutic trial of metformin and bortezomib in a mouse model of tuberous sclerosis complex (TSC). PLoS One. 2012; 7(2):e31900. PMID: 22363765.
    Citations: 8     Fields:    Translation:HumansAnimals
  52. Ricoult SJ, Manning BD. The multifaceted role of mTORC1 in the control of lipid metabolism. EMBO Rep. 2013 Mar 01; 14(3):242-51. PMID: 23399656.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  53. Tanaka K, Babic I, Nathanson D, Akhavan D, Guo D, Gini B, Dang J, Zhu S, Yang H, De Jesus J, Amzajerdi AN, Zhang Y, Dibble CC, Dan H, Rinkenbaugh A, Yong WH, Vinters HV, Gera JF, Cavenee WK, Cloughesy TF, Manning BD, Baldwin AS, Mischel PS. Oncogenic EGFR signaling activates an mTORC2-NF-?B pathway that promotes chemotherapy resistance. Cancer Discov. 2011 Nov; 1(6):524-38. PMID: 22145100.
    Citations: 106     Fields:    Translation:HumansCells
  54. De Raedt T, Walton Z, Yecies JL, Li D, Chen Y, Malone CF, Maertens O, Jeong SM, Bronson RT, Lebleu V, Kalluri R, Normant E, Haigis MC, Manning BD, Wong KK, Macleod KF, Cichowski K. Exploiting cancer cell vulnerabilities to develop a combination therapy for ras-driven tumors. Cancer Cell. 2011 Sep 13; 20(3):400-13. PMID: 21907929.
    Citations: 88     Fields:    Translation:AnimalsCells
  55. Yecies JL, Zhang HH, Menon S, Liu S, Yecies D, Lipovsky AI, Gorgun C, Kwiatkowski DJ, Hotamisligil GS, Lee CH, Manning BD. Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways. Cell Metab. 2011 Jul 06; 14(1):21-32. PMID: 21723501.
    Citations: 155     Fields:    Translation:AnimalsCells
  56. Yecies JL, Manning BD. Transcriptional control of cellular metabolism by mTOR signaling. Cancer Res. 2011 Apr 15; 71(8):2815-20. PMID: 21487041.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  57. Yecies JL, Manning BD. mTOR links oncogenic signaling to tumor cell metabolism. J Mol Med (Berl). 2011 Mar; 89(3):221-8. PMID: 21301797.
    Citations: 65     Fields:    Translation:HumansCells
  58. Howell JJ, Manning BD. mTOR couples cellular nutrient sensing to organismal metabolic homeostasis. Trends Endocrinol Metab. 2011 Mar; 22(3):94-102. PMID: 21269838.
    Citations: 120     Fields:    Translation:HumansAnimalsCells
  59. Manning BD. Insulin signaling: inositol phosphates get into the Akt. Cell. 2010 Dec 10; 143(6):861-3. PMID: 21145450.
    Citations: 5     Fields:    
  60. Düvel K, Yecies JL, Menon S, Raman P, Lipovsky AI, Souza AL, Triantafellow E, Ma Q, Gorski R, Cleaver S, Vander Heiden MG, MacKeigan JP, Finan PM, Clish CB, Murphy LO, Manning BD. Activation of a metabolic gene regulatory network downstream of mTOR complex 1. Mol Cell. 2010 Jul 30; 39(2):171-83. PMID: 20670887.
    Citations: 503     Fields:    Translation:HumansAnimalsCells
  61. Yecies JL, Manning BD. Chewing the fat on tumor cell metabolism. Cell. 2010 Jan 08; 140(1):28-30. PMID: 20085702.
    Citations: 8     Fields:    Translation:Humans
  62. Dibble CC, Manning BD. A molecular link between AKT regulation and chemotherapeutic response. Cancer Cell. 2009 Sep 08; 16(3):178-80. PMID: 19732717.
    Citations: 10     Fields:    Translation:HumansCells
  63. Dibble CC, Asara JM, Manning BD. Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1. Mol Cell Biol. 2009 Nov; 29(21):5657-70. PMID: 19720745.
    Citations: 171     Fields:    Translation:HumansAnimalsCells
  64. Huang J, Wu S, Wu CL, Manning BD. Signaling events downstream of mammalian target of rapamycin complex 2 are attenuated in cells and tumors deficient for the tuberous sclerosis complex tumor suppressors. Cancer Res. 2009 Aug 01; 69(15):6107-14. PMID: 19602587.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
  65. Zhang HH, Huang J, Düvel K, Boback B, Wu S, Squillace RM, Wu CL, Manning BD. Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway. PLoS One. 2009 Jul 10; 4(7):e6189. PMID: 19593385.
    Citations: 114     Fields:    Translation:HumansAnimalsCells
  66. James MF, Han S, Polizzano C, Plotkin SR, Manning BD, Stemmer-Rachamimov AO, Gusella JF, Ramesh V. NF2/merlin is a novel negative regulator of mTOR complex 1, and activation of mTORC1 is associated with meningioma and schwannoma growth. Mol Cell Biol. 2009 Aug; 29(15):4250-61. PMID: 19451225.
    Citations: 84     Fields:    Translation:HumansAnimalsCells
  67. Manning BD. Challenges and opportunities in defining the essential cancer kinome. Sci Signal. 2009 Mar 24; 2(63):pe15. PMID: 19318621.
    Citations: 17     Fields:    Translation:HumansCells
  68. Huang J, Manning BD. A complex interplay between Akt, TSC2 and the two mTOR complexes. Biochem Soc Trans. 2009 Feb; 37(Pt 1):217-22. PMID: 19143635.
    Citations: 236     Fields:    Translation:HumansAnimals
  69. Menon S, Manning BD. Common corruption of the mTOR signaling network in human tumors. Oncogene. 2008 Dec; 27 Suppl 2:S43-51. PMID: 19956179.
    Citations: 109     Fields:    Translation:HumansAnimalsCells
  70. Chakrabarti P, Anno T, Manning BD, Luo Z, Kandror KV. The mammalian target of rapamycin complex 1 regulates leptin biosynthesis in adipocytes at the level of translation: the role of the 5'-untranslated region in the expression of leptin messenger ribonucleic acid. Mol Endocrinol. 2008 Oct; 22(10):2260-7. PMID: 18653778.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  71. Huang J, Manning BD. The TSC1-TSC2 complex: a molecular switchboard controlling cell growth. Biochem J. 2008 Jun 01; 412(2):179-90. PMID: 18466115.
    Citations: 360     Fields:    Translation:HumansAnimalsCells
  72. Huang J, Dibble CC, Matsuzaki M, Manning BD. The TSC1-TSC2 complex is required for proper activation of mTOR complex 2. Mol Cell Biol. 2008 Jun; 28(12):4104-15. PMID: 18411301.
    Citations: 188     Fields:    Translation:HumansAnimalsCells
  73. Ozcan U, Ozcan L, Yilmaz E, Düvel K, Sahin M, Manning BD, Hotamisligil GS. Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis. Mol Cell. 2008 Mar 14; 29(5):541-51. PMID: 18342602.
    Citations: 178     Fields:    Translation:HumansAnimalsCells
  74. Manning BD, Cantley LC. AKT/PKB signaling: navigating downstream. Cell. 2007 Jun 29; 129(7):1261-74. PMID: 17604717.
    Citations: 1902     Fields:    Translation:Cells
  75. Zhang HH, Lipovsky AI, Dibble CC, Sahin M, Manning BD. S6K1 regulates GSK3 under conditions of mTOR-dependent feedback inhibition of Akt. Mol Cell. 2006 Oct 20; 24(2):185-97. PMID: 17052453.
    Citations: 104     Fields:    Translation:HumansAnimalsCells
  76. Prichard R, Butt J, Al-Sariff N, Frohlich S, Murphy S, Manning B, Ravi N, Reynolds JV. Management of spontaneous rupture of the oesophagus (Boerhaave's syndrome): single centre experience of 18 cases. Ir J Med Sci. 2006 Oct-Dec; 175(4):66-70. PMID: 17312833.
    Citations: 1     Fields:    Translation:Humans
  77. Sodhi A, Chaisuparat R, Hu J, Ramsdell AK, Manning BD, Sausville EA, Sawai ET, Molinolo A, Gutkind JS, Montaner S. The TSC2/mTOR pathway drives endothelial cell transformation induced by the Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor. Cancer Cell. 2006 Aug; 10(2):133-43. PMID: 16904612.
    Citations: 62     Fields:    Translation:HumansAnimalsCells
  78. Kwiatkowski DJ, Manning BD. Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways. Hum Mol Genet. 2005 Oct 15; 14 Spec No. 2:R251-8. PMID: 16244323.
    Citations: 158     Fields:    Translation:Cells
  79. Manning BD, Logsdon MN, Lipovsky AI, Abbott D, Kwiatkowski DJ, Cantley LC. Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2. Genes Dev. 2005 Aug 01; 19(15):1773-8. PMID: 16027169.
    Citations: 110     Fields:    Translation:HumansAnimalsCells
  80. Brugarolas J, Lei K, Hurley RL, Manning BD, Reiling JH, Hafen E, Witters LA, Ellisen LW, Kaelin WG. Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex. Genes Dev. 2004 Dec 01; 18(23):2893-904. PMID: 15545625.
    Citations: 400     Fields:    Translation:AnimalsCells
  81. Manning BD. Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis. J Cell Biol. 2004 Nov 08; 167(3):399-403. PMID: 15533996.
    Citations: 181     Fields:    Translation:HumansCells
  82. Shaw RJ, Bardeesy N, Manning BD, Lopez L, Kosmatka M, DePinho RA, Cantley LC. The LKB1 tumor suppressor negatively regulates mTOR signaling. Cancer Cell. 2004 Jul; 6(1):91-9. PMID: 15261145.
    Citations: 334     Fields:    Translation:AnimalsCells
  83. Manning BD, Cantley LC. Rheb fills a GAP between TSC and TOR. Trends Biochem Sci. 2003 Nov; 28(11):573-6. PMID: 14607085.
    Citations: 148     Fields:    Translation:HumansCells
  84. Luo J, Manning BD, Cantley LC. Targeting the PI3K-Akt pathway in human cancer: rationale and promise. Cancer Cell. 2003 Oct; 4(4):257-62. PMID: 14585353.
    Citations: 343     Fields:    Translation:HumansAnimalsCells
  85. Tee AR, Manning BD, Roux PP, Cantley LC, Blenis J. Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb. Curr Biol. 2003 Aug 05; 13(15):1259-68. PMID: 12906785.
    Citations: 376     Fields:    Translation:HumansCells
  86. Manning BD, Cantley LC. United at last: the tuberous sclerosis complex gene products connect the phosphoinositide 3-kinase/Akt pathway to mammalian target of rapamycin (mTOR) signalling. Biochem Soc Trans. 2003 Jun; 31(Pt 3):573-8. PMID: 12773158.
    Citations: 69     Fields:    Translation:HumansCells
  87. Manning BD, Cantley LC. Hitting the target: emerging technologies in the search for kinase substrates. Sci STKE. 2002 Dec 10; 2002(162):pe49. PMID: 12475999.
    Citations: 45     Fields:    Translation:HumansAnimals
  88. Tee AR, Fingar DC, Manning BD, Kwiatkowski DJ, Cantley LC, Blenis J. Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling. Proc Natl Acad Sci U S A. 2002 Oct 15; 99(21):13571-6. PMID: 12271141.
    Citations: 230     Fields:    Translation:HumansCells
  89. Manning BD, Tee AR, Logsdon MN, Blenis J, Cantley LC. Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. Mol Cell. 2002 Jul; 10(1):151-62. PMID: 12150915.
    Citations: 508     Fields:    Translation:HumansAnimalsCells
  90. Manning BD, Snyder M. Drivers and passengers wanted! the role of kinesin-associated proteins. Trends Cell Biol. 2000 Jul; 10(7):281-9. PMID: 10856931.
    Citations: 16     Fields:    Translation:Animals
  91. Barrett JG, Manning BD, Snyder M. The Kar3p kinesin-related protein forms a novel heterodimeric structure with its associated protein Cik1p. Mol Biol Cell. 2000 Jul; 11(7):2373-85. PMID: 10888675.
    Citations: 27     Fields:    Translation:AnimalsCells
  92. Manning BD, Barrett JG, Wallace JA, Granok H, Snyder M. Differential regulation of the Kar3p kinesin-related protein by two associated proteins, Cik1p and Vik1p. J Cell Biol. 1999 Mar 22; 144(6):1219-33. PMID: 10087265.
    Citations: 50     Fields:    Translation:AnimalsCells
  93. Manning BD, Padmanabha R, Snyder M. The Rho-GEF Rom2p localizes to sites of polarized cell growth and participates in cytoskeletal functions in Saccharomyces cerevisiae. Mol Biol Cell. 1997 Oct; 8(10):1829-44. PMID: 9348527.
    Citations: 38     Fields:    Translation:AnimalsCells
  94. Lessie TG, Hendrickson W, Manning BD, Devereux R. Genomic complexity and plasticity of Burkholderia cepacia. FEMS Microbiol Lett. 1996 Nov 01; 144(2-3):117-28. PMID: 8900054.
    Citations: 46     Fields:    Translation:CellsPHPublic Health
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.