Harvard Catalyst Profiles

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Ion Hobai, Ph.D., M.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Hobai IA. Mechanisms of cardiac dysfunction in sepsis. Shock. 2022 Sep 26. PMID: 36155956.
    Citations:    Fields:    
  2. Croteau D, Luptak I, Chambers JM, Hobai I, Panagia M, Pimentel DR, Siwik DA, Qin F, Colucci WS. Effects of Sodium-Glucose Linked Transporter 2 Inhibition With Ertugliflozin on Mitochondrial Function, Energetics, and Metabolic Gene Expression in the Presence and Absence of Diabetes Mellitus in Mice. J Am Heart Assoc. 2021 07 06; 10(13):e019995. PMID: 34169737.
    Citations: 12     Fields:    Translation:AnimalsCells
  3. Goodman JB, Qin F, Morgan RJ, Chambers JM, Croteau D, Siwik DA, Hobai I, Panagia M, Luptak I, Bachschmid M, Tong X, Pimentel DR, Cohen RA, Colucci WS. Redox-Resistant SERCA [Sarco(endo)plasmic Reticulum Calcium ATPase] Attenuates Oxidant-Stimulated Mitochondrial Calcium and Apoptosis in Cardiac Myocytes and Pressure Overload-Induced Myocardial Failure in Mice. Circulation. 2020 12 22; 142(25):2459-2469. PMID: 33076678.
    Citations: 4     Fields:    Translation:AnimalsCells
  4. Luptak I, Croteau D, Valentine C, Qin F, Siwik DA, Remick DG, Colucci WS, Hobai IA. Myocardial Redox Hormesis Protects the Heart of Female Mice in Sepsis. Shock. 2019 07; 52(1):52-60. PMID: 30102640.
    Citations: 3     Fields:    Translation:AnimalsCells
  5. Morse JC, Huang J, Khona N, Miller EJ, Siwik DA, Colucci WS, Hobai IA. Up-regulation of Intracellular Calcium Handling Underlies the Recovery of Endotoxemic Cardiomyopathy in Mice. Anesthesiology. 2017 06; 126(6):1125-1138. PMID: 28410273.
    Citations: 3     Fields:    Translation:AnimalsCells
  6. Hobai IA. Anesthetics, the Ryanodine Receptors, and the Heart. Anesthesiology. 2017 03; 126(3):373-375. PMID: 28079565.
    Citations:    Fields:    Translation:HumansCells
  7. Hobai IA, Aziz K, Buys ES, Brouckaert P, Siwik DA, Colucci WS. Distinct Myocardial Mechanisms Underlie Cardiac Dysfunction in Endotoxemic Male and Female Mice. Shock. 2016 12; 46(6):713-722. PMID: 27405063.
    Citations: 5     Fields:    Translation:AnimalsCells
  8. Hobai IA, Edgecomb J, LaBarge K, Colucci WS. Dysregulation of intracellular calcium transporters in animal models of sepsis-induced cardiomyopathy. Shock. 2015 Jan; 43(1):3-15. PMID: 25186837.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  9. Hobai IA, Morse JC, Siwik DA, Colucci WS. Lipopolysaccharide and cytokines inhibit rat cardiomyocyte contractility in vitro. J Surg Res. 2015 Feb; 193(2):888-901. PMID: 25439505; PMCID: PMC4268427.
    Citations: 16     Fields:    Translation:AnimalsCells
  10. Hobai IA, Buys ES, Morse JC, Edgecomb J, Weiss EH, Armoundas AA, Hou X, Khandelwal AR, Siwik DA, Brouckaert P, Cohen RA, Colucci WS. SERCA Cys674 sulphonylation and inhibition of L-type Ca2+ influx contribute to cardiac dysfunction in endotoxemic mice, independent of cGMP synthesis. Am J Physiol Heart Circ Physiol. 2013 Oct 15; 305(8):H1189-200. PMID: 23934853.
    Citations: 14     Fields:    Translation:AnimalsCells
  11. Hobai IA, Chhangani SV, Alfille PH. Anesthesia for tracheal resection and reconstruction. Anesthesiol Clin. 2012 Dec; 30(4):709-30. PMID: 23089505.
    Citations: 17     Fields:    Translation:Humans
  12. Hobai IA, Gauran C, Chitilian HV, Ehrenfeld JM, Levinson J, Sandberg WS. The management and outcome of documented intraoperative heart rate-related electrocardiographic changes. J Cardiothorac Vasc Anesth. 2011 Oct; 25(5):791-8. PMID: 21724417.
    Citations:    Fields:    Translation:Humans
  13. Hobai IA. Letter by Hobai regarding article, "Long-term anabolic-androgenic steroid use is associated with left ventricular dysfunction". Circ Heart Fail. 2010 Nov; 3(6):e30; author reply e31. PMID: 21081736.
    Citations:    Fields:    Translation:Humans
  14. Buys ES, Cauwels A, Raher MJ, Passeri JJ, Hobai I, Cawley SM, Rauwerdink KM, Thibault H, Sips PY, Thoonen R, Scherrer-Crosbie M, Ichinose F, Brouckaert P, Bloch KD. sGC(alpha)1(beta)1 attenuates cardiac dysfunction and mortality in murine inflammatory shock models. Am J Physiol Heart Circ Physiol. 2009 Aug; 297(2):H654-63. PMID: 19502556.
    Citations: 28     Fields:    Translation:AnimalsCells
  15. Hobai IA. Atrioventricular block induced by indigo carmine. Can J Anaesth. 2008 Oct; 55(10):717-8. PMID: 18835972.
    Citations:    Fields:    Translation:Humans
  16. Hobai IA, Bittner EA, Grecu L. Perioperative spinal cord infarction in nonaortic surgery: report of three cases and review of the literature. J Clin Anesth. 2008 Jun; 20(4):307-12. PMID: 18617133.
    Citations: 8     Fields:    Translation:Humans
  17. Hobai IA, Maack C, O'Rourke B. Partial inhibition of sodium/calcium exchange restores cellular calcium handling in canine heart failure. Circ Res. 2004 Aug 06; 95(3):292-9. PMID: 15217911; PMCID: PMC2703731.
    Citations: 31     Fields:    Translation:AnimalsCells
  18. Hobai IA, O'Rourke B. The potential of Na+/Ca2+ exchange blockers in the treatment of cardiac disease. Expert Opin Investig Drugs. 2004 Jun; 13(6):653-64. PMID: 15174951.
    Citations: 11     Fields:    Translation:Humans
  19. Armoundas AA, Hobai IA, Tomaselli GF, Winslow RL, O'Rourke B. Role of sodium-calcium exchanger in modulating the action potential of ventricular myocytes from normal and failing hearts. Circ Res. 2003 Jul 11; 93(1):46-53. PMID: 12805237; PMCID: PMC1237121.
    Citations: 69     Fields:    Translation:AnimalsCells
  20. Barouch LA, Harrison RW, Skaf MW, Rosas GO, Cappola TP, Kobeissi ZA, Hobai IA, Lemmon CA, Burnett AL, O'Rourke B, Rodriguez ER, Huang PL, Lima JA, Berkowitz DE, Hare JM. Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms. Nature. 2002 Mar 21; 416(6878):337-9. PMID: 11907582.
    Citations: 260     Fields:    Translation:AnimalsCells
  21. Hobai IA, O'Rourke B. Decreased sarcoplasmic reticulum calcium content is responsible for defective excitation-contraction coupling in canine heart failure. Circulation. 2001 Mar 20; 103(11):1577-84. PMID: 11257088.
    Citations: 102     Fields:    Translation:HumansAnimalsCells
  22. Hobai IA, O'Rourke B. Enhanced Ca(2+)-activated Na(+)-Ca(2+) exchange activity in canine pacing-induced heart failure. Circ Res. 2000 Oct 13; 87(8):690-8. PMID: 11029405.
    Citations: 60     Fields:    Translation:AnimalsCells
  23. Hobai IA, Hancox JC, Levi AJ. Inhibition by nickel of the L-type Ca channel in guinea pig ventricular myocytes and effect of internal cAMP. Am J Physiol Heart Circ Physiol. 2000 Aug; 279(2):H692-701. PMID: 10924068.
    Citations: 13     Fields:    Translation:AnimalsCells
  24. Hobai IA, Levi AJ. Coming full circle: membrane potential, sarcolemmal calcium influx and excitation-contraction coupling in heart muscle. Cardiovasc Res. 1999 Dec; 44(3):477-87. PMID: 10690279.
    Citations: 4     Fields:    Translation:AnimalsCells
  25. Hinde AK, Perchenet L, Hobai IA, Levi AJ, Hancox JC. Inhibition of Na/Ca exchange by external Ni in guinea-pig ventricular myocytes at 37 degrees C, dialysed internally with cAMP-free and cAMP-containing solutions. Cell Calcium. 1999 Apr; 25(4):321-31. PMID: 10456229.
    Citations: 15     Fields:    Translation:AnimalsCells
  26. Hobai IA, Howarth FC, Pabbathi VK, Dalton GR, Hancox JC, Zhu JQ, Howlett SE, Ferrier GR, Levi AJ. "Voltage-activated Ca release" in rabbit, rat and guinea-pig cardiac myocytes, and modulation by internal cAMP. Pflugers Arch. 1997 Dec; 435(1):164-73. PMID: 9359916.
    Citations: 18     Fields:    Translation:AnimalsCells
  27. Levi AJ, Dalton GR, Hancox JC, Mitcheson JS, Issberner J, Bates JA, Evans SJ, Howarth FC, Hobai IA, Jones JV. Role of intracellular sodium overload in the genesis of cardiac arrhythmias. J Cardiovasc Electrophysiol. 1997 Jun; 8(6):700-21. PMID: 9209972.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  28. Hobai IA, Bates JA, Howarth FC, Levi AJ. Inhibition by external Cd2+ of Na/Ca exchange and L-type Ca channel in rabbit ventricular myocytes. Am J Physiol. 1997 May; 272(5 Pt 2):H2164-72. PMID: 9176282.
    Citations: 21     Fields:    Translation:AnimalsCells
  29. Hobai IA, Khananshvili D, Levi AJ. The peptide "FRCRCFa", dialysed intracellularly, inhibits the Na/Ca exchange in rabbit ventricular myocytes with high affinity. Pflugers Arch. 1997 Feb; 433(4):455-63. PMID: 9000424.
    Citations: 9     Fields:    Translation:Animals
  30. Sima A, Hobai I, Stancu C, Cinteza M, Gherasim L. Correlated biochemical modifications of plasma lipoproteins in coronary heart disease: an accelerating pathologic factor. Rom J Intern Med. 1996 Jan-Jun; 34(1-2):55-64. PMID: 8908631.
    Citations: 1     Fields:    Translation:Humans
  31. Colintineanu L, Hobai I. [Sclero-atrophic lichen]. Bull Soc Fr Dermatol Syphiligr. 1970; 77(4):482-3. PMID: 5532792.
    Citations:    Fields:    Translation:Humans
  32. Colintineanu L, Hobai I. [Disseminated tuberculous lupus. Clinical and etiopathogenic considerations apropos of a case]. Bull Soc Fr Dermatol Syphiligr. 1968; 75(6):851-3. PMID: 5713008.
    Citations:    Fields:    Translation:Humans
  33. Dimitriu R, Cinca I, Colea A, Onaca P, Hobai I. [Zoster encephalitis. Clinical study]. Neurol Psihiatr Neurochir. 1965 Mar-Apr; 10(2):127-31. PMID: 5827634.
    Citations:    Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.