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Jack William Szostak, Ph.D.

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  1. R01GM053936 (SZOSTAK, JACK W) Jun 1, 1996 - Jun 30, 2005
    NIH/NIGMS
    IN VITRO EVOLUTION OF NEW MOLECULAR FUNCTIONS
    Role: Principal Investigator
  2. R01GM045315 (SZOSTAK, JACK W) Jul 1, 1991 - Jun 30, 1995
    NIH/NIGMS
    RIBOZYME-SUBSTRATE INTERACTIONS
    Role: Principal Investigator
  3. T32CA009595 (HARLOW, EDWARD E) Aug 1, 1989 - Jun 30, 2005
    NIH/NCI
    GENETICS OF CANCER AND INHERITED DISEASES
    Role: Co-Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Joyce GF, Szostak JW. Protocells and RNA Self-Replication. Cold Spring Harb Perspect Biol. 2018 Sep 04; 10(9). PMID: 30181195.
    View in: PubMed
  2. Giurgiu C, Wright TH, O'Flaherty DK, Szostak JW. A Fluorescent G-Quadruplex Sensor for Chemical RNA Copying. Angew Chem Int Ed Engl. 2018 Jul 26; 57(31):9844-9848. PMID: 29939457.
    View in: PubMed
  3. Lin S, Liu Q, Lelyveld VS, Choe J, Szostak JW, Gregory RI. Mettl1/Wdr4-Mediated m7G tRNA Methylome Is Required for Normal mRNA Translation and Embryonic Stem Cell Self-Renewal and Differentiation. Mol Cell. 2018 Jul 19; 71(2):244-255.e5. PMID: 29983320.
    View in: PubMed
  4. Zhang W, Walton T, Li L, Szostak JW. Crystallographic observation of nonenzymatic RNA primer extension. Elife. 2018 May 31; 7. PMID: 29851379.
    View in: PubMed
  5. Szostak J. How Did Life Begin? Sci Am. 2018 May 15; 318(6):65-67. PMID: 29949547.
    View in: PubMed
  6. Szostak J. How Did Life Begin? Nature. 2018 May; 557(7704):S13-S15. PMID: 29743709.
    View in: PubMed
  7. O'Flaherty DK, Kamat NP, Mirza FN, Li L, Prywes N, Szostak JW. Copying of Mixed-Sequence RNA Templates inside Model Protocells. J Am Chem Soc. 2018 04 18; 140(15):5171-5178. PMID: 29608310.
    View in: PubMed
  8. Jin L, Kamat NP, Jena S, Szostak JW. Fatty Acid/Phospholipid Blended Membranes: A Potential Intermediate State in Protocellular Evolution. Small. 2018 Apr; 14(15):e1704077. PMID: 29479815.
    View in: PubMed
  9. Zhang W, Tam CP, Zhou L, Oh SS, Wang J, Szostak JW. Structural Rationale for the Enhanced Catalysis of Nonenzymatic RNA Primer Extension by a Downstream Oligonucleotide. J Am Chem Soc. 2018 02 28; 140(8):2829-2840. PMID: 29411978.
    View in: PubMed
  10. Jin L, Engelhart AE, Adamala KP, Szostak JW. Preparation, Purification, and Use of Fatty Acid-containing Liposomes. J Vis Exp. 2018 02 09; (132). PMID: 29553563.
    View in: PubMed
  11. Todd ZR, Fahrenbach AC, Magnani CJ, Ranjan S, Björkbom A, Szostak JW, Sasselov DD. Solvated-electron production using cyanocuprates is compatible with the UV-environment on a Hadean-Archaean Earth. Chem Commun (Camb). 2018 Jan 25; 54(9):1121-1124. PMID: 29334083.
    View in: PubMed
  12. Tam CP, Zhou L, Fahrenbach AC, Zhang W, Walton T, Szostak JW. Synthesis of a Nonhydrolyzable Nucleotide Phosphoroimidazolide Analogue That Catalyzes Nonenzymatic RNA Primer Extension. J Am Chem Soc. 2018 01 17; 140(2):783-792. PMID: 29251930.
    View in: PubMed
  13. Jia TZ, Fahrenbach AC, Kamat NP, Adamala KP, Szostak JW. Retraction: Oligoarginine peptides slow strand annealing and assist non-enzymatic RNA replication. Nat Chem. 2017 11 23; 9(12):1286. PMID: 29168488.
    View in: PubMed
  14. Giurgiu C, Li L, O'Flaherty DK, Tam CP, Szostak JW. A Mechanistic Explanation for the Regioselectivity of Nonenzymatic RNA Primer Extension. J Am Chem Soc. 2017 11 22; 139(46):16741-16747. PMID: 29112424.
    View in: PubMed
  15. Walton T, Szostak JW. A Kinetic Model of Nonenzymatic RNA Polymerization by Cytidine-5'-phosphoro-2-aminoimidazolide. Biochemistry. 2017 10 31; 56(43):5739-5747. PMID: 29022704.
    View in: PubMed
  16. Ransey E, Björkbom A, Lelyveld VS, Biecek P, Pantano L, Szostak JW, Sliz P. Comparative analysis of LIN28-RNA binding sites identified at single nucleotide resolution. RNA Biol. 2017 12 02; 14(12):1756-1765. PMID: 28945502.
    View in: PubMed
  17. Greider C, Hopkins N, Steitz J, Amon A, Asai D, Barres B, Bass B, Bassler B, Birgeneau R, Bjorkman P, Botchan M, Brugge J, Cech T, Colwell R, Craig N, deLange T, Eisen M, Gottesman S, Green R, Handelsman J, Kimble J, King MC, Lehmann R, Marder E, Mullins D, O'Shea E, Schmid S, Seydoux G, Spradling A, Storz G, Szostak J, Telesnitsky A, Tilghman S, Tjian R, Vale R, Wolberger C, Zakian V. Not just Salk. Science. 2017 09 15; 357(6356):1105-1106. PMID: 28912235.
    View in: PubMed
  18. Szostak JW. The Narrow Road to the Deep Past: In Search of the Chemistry of the Origin of Life. Angew Chem Int Ed Engl. 2017 Sep 04; 56(37):11037-11043. PMID: 28514493.
    View in: PubMed
  19. Bonfio C, Valer L, Scintilla S, Shah S, Evans DJ, Jin L, Szostak JW, Sasselov DD, Sutherland JD, Mansy SS. UV-light-driven prebiotic synthesis of iron-sulfur clusters. Nat Chem. 2017 Dec; 9(12):1229-1234. PMID: 29168482.
    View in: PubMed
  20. Zhang W, Tam CP, Walton T, Fahrenbach AC, Birrane G, Szostak JW. Insight into the mechanism of nonenzymatic RNA primer extension from the structure of an RNA-GpppG complex. Proc Natl Acad Sci U S A. 2017 07 18; 114(29):7659-7664. PMID: 28673998.
    View in: PubMed
  21. Fahrenbach AC, Giurgiu C, Tam CP, Li L, Hongo Y, Aono M, Szostak JW. Common and Potentially Prebiotic Origin for Precursors of Nucleotide Synthesis and Activation. J Am Chem Soc. 2017 07 05; 139(26):8780-8783. PMID: 28640999.
    View in: PubMed
  22. Stairs S, Nikmal A, Bucar DK, Zheng SL, Szostak JW, Powner MW. Divergent prebiotic synthesis of pyrimidine and 8-oxo-purine ribonucleotides. Nat Commun. 2017 May 19; 8:15270. PMID: 28524845.
    View in: PubMed
  23. Li L, Prywes N, Tam CP, O'Flaherty DK, Lelyveld VS, Izgu EC, Pal A, Szostak JW. Enhanced Nonenzymatic RNA Copying with 2-Aminoimidazole Activated Nucleotides. J Am Chem Soc. 2017 02 08; 139(5):1810-1813. PMID: 28117989.
    View in: PubMed
  24. Tam CP, Fahrenbach AC, Björkbom A, Prywes N, Izgu EC, Szostak JW. Downstream Oligonucleotides Strongly Enhance the Affinity of GMP to RNA Primer-Template Complexes. J Am Chem Soc. 2017 01 18; 139(2):571-574. PMID: 28055190.
    View in: PubMed
  25. Izgu EC, Björkbom A, Kamat NP, Lelyveld VS, Zhang W, Jia TZ, Szostak JW. N-Carboxyanhydride-Mediated Fatty Acylation of Amino Acids and Peptides for Functionalization of Protocell Membranes. J Am Chem Soc. 2016 12 28; 138(51):16669-16676. PMID: 27959544.
    View in: PubMed
  26. Zhang W, Tam CP, Wang J, Szostak JW. Unusual Base-Pairing Interactions in Monomer-Template Complexes. ACS Cent Sci. 2016 Dec 28; 2(12):916-926. PMID: 28058281.
    View in: PubMed
  27. Pal A, Das RS, Zhang W, Lang M, McLaughlin LW, Szostak JW. Effect of terminal 3'-hydroxymethyl modification of an RNA primer on nonenzymatic primer extension. Chem Commun (Camb). 2016 Sep 29; 52(80):11905-11907. PMID: 27722518.
    View in: PubMed
  28. Walton T, Szostak JW. A Highly Reactive Imidazolium-Bridged Dinucleotide Intermediate in Nonenzymatic RNA Primer Extension. J Am Chem Soc. 2016 09 14; 138(36):11996-2002. PMID: 27552367.
    View in: PubMed
  29. Prywes N, Blain JC, Del Frate F, Szostak JW. Nonenzymatic copying of RNA templates containing all four letters is catalyzed by activated oligonucleotides. Elife. 2016 06 28; 5. PMID: 27351102; PMCID: PMC4959843.
    View in: PubMed, PubMed Central
  30. Jia TZ, Fahrenbach AC, Kamat NP, Adamala KP, Szostak JW. Oligoarginine peptides slow strand annealing and assist non-enzymatic RNA replication. Nat Chem. 2016 10; 8(10):915-21. PMID: 27657866.
    View in: PubMed
  31. Prywes N, Michaels YS, Pal A, Oh SS, Szostak JW. Thiolated uridine substrates and templates improve the rate and fidelity of ribozyme-catalyzed RNA copying. Chem Commun (Camb). 2016 May 05; 52(39):6529-32. PMID: 27109314.
    View in: PubMed
  32. Adamala KP, Engelhart AE, Szostak JW. Collaboration between primitive cell membranes and soluble catalysts. Nat Commun. 2016 Mar 21; 7:11041. PMID: 26996603; PMCID: PMC4802160.
    View in: PubMed, PubMed Central
  33. Li L, Lelyveld VS, Prywes N, Szostak JW. Experimental and Computational Evidence for a Loose Transition State in Phosphoroimidazolide Hydrolysis. J Am Chem Soc. 2016 Mar 30; 138(12):3986-9. PMID: 26974265.
    View in: PubMed
  34. Engelhart AE, Adamala KP, Szostak JW. A simple physical mechanism enables homeostasis in primitive cells. Nat Chem. 2016 05; 8(5):448-53. PMID: 27102678.
    View in: PubMed
  35. Izgu EC, Oh SS, Szostak JW. Synthesis of activated 3'-amino-3'-deoxy-2-thio-thymidine, a superior substrate for the nonenzymatic copying of nucleic acid templates. Chem Commun (Camb). 2016 Mar 04; 52(18):3684-6. PMID: 26857159.
    View in: PubMed
  36. Szostak JW. On the origin of life. Medicina (B Aires). 2016; 76(4):199-203. PMID: 27576276.
    View in: PubMed
  37. Lelyveld VS, Björkbom A, Ransey EM, Sliz P, Szostak JW. Pinpointing RNA-Protein Cross-Links with Site-Specific Stable Isotope-Labeled Oligonucleotides. J Am Chem Soc. 2015 Dec 16; 137(49):15378-81. PMID: 26583201; PMCID: PMC4697197.
    View in: PubMed, PubMed Central
  38. Björkbom A, Lelyveld VS, Zhang S, Zhang W, Tam CP, Blain JC, Szostak JW. Bidirectional Direct Sequencing of Noncanonical RNA by Two-Dimensional Analysis of Mass Chromatograms. J Am Chem Soc. 2015 Nov 18; 137(45):14430-8. PMID: 26495937.
    View in: PubMed
  39. Larsen AT, Fahrenbach AC, Sheng J, Pian J, Szostak JW. Thermodynamic insights into 2-thiouridine-enhanced RNA hybridization. Nucleic Acids Res. 2015 Sep 18; 43(16):7675-87. PMID: 26240387; PMCID: PMC4652770.
    View in: PubMed, PubMed Central
  40. Kamat NP, Tobé S, Hill IT, Szostak JW. Electrostatic Localization of RNA to Protocell Membranes by Cationic Hydrophobic Peptides. Angew Chem Int Ed Engl. 2015 Sep 28; 54(40):11735-9. PMID: 26223820; PMCID: PMC4600236.
    View in: PubMed, PubMed Central
  41. Adamala K, Engelhart AE, Kamat NP, Jin L, Szostak JW. Construction of a liposome dialyzer for the preparation of high-value, small-volume liposome formulations. Nat Protoc. 2015 Jun; 10(6):927-38. PMID: 26020615; PMCID: PMC4982460.
    View in: PubMed, PubMed Central
  42. Izgu EC, Fahrenbach AC, Zhang N, Li L, Zhang W, Larsen AT, Blain JC, Szostak JW. Uncovering the thermodynamics of monomer binding for RNA replication. J Am Chem Soc. 2015 May 20; 137(19):6373-82. PMID: 25901790; PMCID: PMC4984997.
    View in: PubMed, PubMed Central
  43. Heuberger BD, Pal A, Del Frate F, Topkar VV, Szostak JW. Replacing uridine with 2-thiouridine enhances the rate and fidelity of nonenzymatic RNA primer extension. J Am Chem Soc. 2015 Feb 25; 137(7):2769-75. PMID: 25654265; PMCID: PMC4985000.
    View in: PubMed, PubMed Central
  44. Adamala K, Engelhart AE, Szostak JW. Generation of functional RNAs from inactive oligonucleotide complexes by non-enzymatic primer extension. J Am Chem Soc. 2015 Jan 14; 137(1):483-9. PMID: 25521912; PMCID: PMC4984999.
    View in: PubMed, PubMed Central
  45. Hentrich C, Szostak JW. Controlled growth of filamentous fatty acid vesicles under flow. Langmuir. 2014 Dec 16; 30(49):14916-25. PMID: 25402759; PMCID: PMC4985002.
    View in: PubMed, PubMed Central
  46. Budin I, Prwyes N, Zhang N, Szostak JW. Chain-length heterogeneity allows for the assembly of fatty acid vesicles in dilute solutions. Biophys J. 2014 Oct 07; 107(7):1582-90. PMID: 25296310; PMCID: PMC4190651.
    View in: PubMed, PubMed Central
  47. Sheng J, Larsen A, Heuberger BD, Blain JC, Szostak JW. Crystal structure studies of RNA duplexes containing s(2)U:A and s(2)U:U base pairs. J Am Chem Soc. 2014 Oct 01; 136(39):13916-24. PMID: 25188906; PMCID: PMC4183603.
    View in: PubMed, PubMed Central
  48. Blain JC, Szostak JW. Progress toward synthetic cells. Annu Rev Biochem. 2014; 83:615-40. PMID: 24606140.
    View in: PubMed
  49. Jia TZ, Hentrich C, Szostak JW. Rapid RNA exchange in aqueous two-phase system and coacervate droplets. Orig Life Evol Biosph. 2014 Feb; 44(1):1-12. PMID: 24577897; PMCID: PMC4141154.
    View in: PubMed, PubMed Central
  50. Sheng J, Li L, Engelhart AE, Gan J, Wang J, Szostak JW. Structural insights into the effects of 2'-5' linkages on the RNA duplex. Proc Natl Acad Sci U S A. 2014 Feb 25; 111(8):3050-5. PMID: 24516151; PMCID: PMC3939906.
    View in: PubMed, PubMed Central
  51. Li L, Szostak JW. The free energy landscape of pseudorotation in 3'-5' and 2'-5' linked nucleic acids. J Am Chem Soc. 2014 Feb 19; 136(7):2858-65. PMID: 24499340; PMCID: PMC3982932.
    View in: PubMed, PubMed Central
  52. Blain JC, Ricardo A, Szostak JW. Synthesis and nonenzymatic template-directed polymerization of 2'-amino-2'-deoxythreose nucleotides. J Am Chem Soc. 2014 Feb 05; 136(5):2033-9. PMID: 24409991; PMCID: PMC4105081.
    View in: PubMed, PubMed Central
  53. Adamala K, Szostak JW. Nonenzymatic template-directed RNA synthesis inside model protocells. Science. 2013 Nov 29; 342(6162):1098-100. PMID: 24288333; PMCID: PMC4104020.
    View in: PubMed, PubMed Central
  54. Josephson K, Ricardo A, Szostak JW. mRNA display: from basic principles to macrocycle drug discovery. Drug Discov Today. 2014 Apr; 19(4):388-99. PMID: 24157402.
    View in: PubMed
  55. Zhang S, Blain JC, Zielinska D, Gryaznov SM, Szostak JW. Fast and accurate nonenzymatic copying of an RNA-like synthetic genetic polymer. Proc Natl Acad Sci U S A. 2013 Oct 29; 110(44):17732-7. PMID: 24101473; PMCID: PMC3816440.
    View in: PubMed, PubMed Central
  56. Adamala K, Szostak JW. Competition between model protocells driven by an encapsulated catalyst. Nat Chem. 2013 Jun; 5(6):495-501. PMID: 23695631; PMCID: PMC4041014.
    View in: PubMed, PubMed Central
  57. Engelhart AE, Powner MW, Szostak JW. Functional RNAs exhibit tolerance for non-heritable 2'-5' versus 3'-5' backbone heterogeneity. Nat Chem. 2013 May; 5(5):390-4. PMID: 23609089; PMCID: PMC4088963.
    View in: PubMed, PubMed Central
  58. Zhang S, Zhang N, Blain JC, Szostak JW. Synthesis of N3'-P5'-linked phosphoramidate DNA by nonenzymatic template-directed primer extension. J Am Chem Soc. 2013 Jan 16; 135(2):924-32. PMID: 23252395; PMCID: PMC3548433.
    View in: PubMed, PubMed Central
  59. Zhu TF, Budin I, Szostak JW. Preparation of fatty acid or phospholipid vesicles by thin-film rehydration. Methods Enzymol. 2013; 533:267-74. PMID: 24182932; PMCID: PMC4310237.
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  60. Zhu TF, Budin I, Szostak JW. Preparation of fatty acid micelles. Methods Enzymol. 2013; 533:283-8. PMID: 24182934; PMCID: PMC4310231.
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  61. Zhu TF, Budin I, Szostak JW. Vesicle extrusion through polycarbonate track-etched membranes using a hand-held mini-extruder. Methods Enzymol. 2013; 533:275-82. PMID: 24182933; PMCID: PMC4310236.
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  62. Budin I, Debnath A, Szostak JW. Concentration-driven growth of model protocell membranes. J Am Chem Soc. 2012 Dec 26; 134(51):20812-9. PMID: 23198690; PMCID: PMC3530389.
    View in: PubMed, PubMed Central
  63. Powner MW, Zheng SL, Szostak JW. Multicomponent assembly of proposed DNA precursors in water. J Am Chem Soc. 2012 Aug 22; 134(33):13889-95. PMID: 22839703; PMCID: PMC3424849.
    View in: PubMed, PubMed Central
  64. Zhu TF, Adamala K, Zhang N, Szostak JW. Photochemically driven redox chemistry induces protocell membrane pearling and division. Proc Natl Acad Sci U S A. 2012 Jun 19; 109(25):9828-32. PMID: 22665773; PMCID: PMC3382484.
    View in: PubMed, PubMed Central
  65. Hofmann FT, Szostak JW, Seebeck FP. In vitro selection of functional lantipeptides. J Am Chem Soc. 2012 May 16; 134(19):8038-41. PMID: 22545861; PMCID: PMC3353655.
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  66. Schlippe YV, Hartman MC, Josephson K, Szostak JW. In vitro selection of highly modified cyclic peptides that act as tight binding inhibitors. J Am Chem Soc. 2012 Jun 27; 134(25):10469-77. PMID: 22428867; PMCID: PMC3384292.
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  67. Zhang N, Zhang S, Szostak JW. Activated ribonucleotides undergo a sugar pucker switch upon binding to a single-stranded RNA template. J Am Chem Soc. 2012 Feb 29; 134(8):3691-4. PMID: 22296305; PMCID: PMC3448298.
    View in: PubMed, PubMed Central
  68. Szostak JW. Attempts to define life do not help to understand the origin of life. J Biomol Struct Dyn. 2012; 29(4):599-600. PMID: 22208251; PMCID: PMC4208307.
    View in: PubMed, PubMed Central
  69. Szostak JW. An optimal degree of physical and chemical heterogeneity for the origin of life? Philos Trans R Soc Lond B Biol Sci. 2011 Oct 27; 366(1580):2894-901. PMID: 21930580; PMCID: PMC3158921.
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  70. Trevino SG, Zhang N, Elenko MP, Lupták A, Szostak JW. Evolution of functional nucleic acids in the presence of nonheritable backbone heterogeneity. Proc Natl Acad Sci U S A. 2011 Aug 16; 108(33):13492-7. PMID: 21825162; PMCID: PMC3158193.
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  71. Seebeck FP, Ricardo A, Szostak JW. Artificial lantipeptides from in vitro translations. Chem Commun (Camb). 2011 Jun 07; 47(21):6141-3. PMID: 21528125.
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  72. Budin I, Szostak JW. Physical effects underlying the transition from primitive to modern cell membranes. Proc Natl Acad Sci U S A. 2011 Mar 29; 108(13):5249-54. PMID: 21402937; PMCID: PMC3069173.
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  73. Subtelny AO, Hartman MC, Szostak JW. Optimal codon choice can improve the efficiency and fidelity of N-methyl amino acid incorporation into peptides by in-vitro translation. Angew Chem Int Ed Engl. 2011 Mar 28; 50(14):3164-7. PMID: 21381166; PMCID: PMC4006073.
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  74. Powner MW, Sutherland JD, Szostak JW. Chemoselective multicomponent one-pot assembly of purine precursors in water. J Am Chem Soc. 2010 Nov 24; 132(46):16677-88. PMID: 21043502; PMCID: PMC2984373.
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  75. Szostak JW. DNA ends: just the beginning (Nobel lecture). Angew Chem Int Ed Engl. 2010 Oct 04; 49(41):7386-404. PMID: 20818632.
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  76. Elenko MP, Szostak JW, van Oijen AM. Single-molecule binding experiments on long time scales. Rev Sci Instrum. 2010 Aug; 81(8):083705. PMID: 20815611.
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  77. Schrum JP, Zhu TF, Szostak JW. The origins of cellular life. Cold Spring Harb Perspect Biol. 2010 Sep; 2(9):a002212. PMID: 20484387; PMCID: PMC2926753.
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  78. Rajamani S, Ichida JK, Antal T, Treco DA, Leu K, Nowak MA, Szostak JW, Chen IA. Effect of stalling after mismatches on the error catastrophe in nonenzymatic nucleic acid replication. J Am Chem Soc. 2010 Apr 28; 132(16):5880-5. PMID: 20359213; PMCID: PMC2857888.
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  79. Budin I, Szostak JW. Expanding roles for diverse physical phenomena during the origin of life. Annu Rev Biophys. 2010; 39:245-63. PMID: 20192779; PMCID: PMC4992673.
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  80. Bruckner RJ, Mansy SS, Ricardo A, Mahadevan L, Szostak JW. Flip-flop-induced relaxation of bending energy: implications for membrane remodeling. Biophys J. 2009 Dec 16; 97(12):3113-22. PMID: 20006948; PMCID: PMC2793357.
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  81. Schrum JP, Ricardo A, Krishnamurthy M, Blain JC, Szostak JW. Efficient and rapid template-directed nucleic acid copying using 2'-amino-2',3'-dideoxyribonucleoside-5'-phosphorimidazolide monomers. J Am Chem Soc. 2009 Oct 14; 131(40):14560-70. PMID: 19757789; PMCID: PMC2759813.
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  82. Mansy SS, Szostak JW. Reconstructing the emergence of cellular life through the synthesis of model protocells. Cold Spring Harb Symp Quant Biol. 2009; 74:47-54. PMID: 19734203.
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  83. Lin S, Horning DP, Szostak JW, Chaput JC. Conformational analysis of DNA repair intermediates by time-resolved fluorescence spectroscopy. J Phys Chem A. 2009 Sep 03; 113(35):9585-7. PMID: 19673467; PMCID: PMC2733762.
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  84. Ricardo A, Szostak JW. Origin of life on earth. Sci Am. 2009 Sep; 301(3):54-61. PMID: 19708528.
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  85. Elenko MP, Szostak JW, van Oijen AM. Single-molecule imaging of an in vitro-evolved RNA aptamer reveals homogeneous ligand binding kinetics. J Am Chem Soc. 2009 Jul 29; 131(29):9866-7. PMID: 19572753; PMCID: PMC2716146.
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  86. Budin I, Bruckner RJ, Szostak JW. Formation of protocell-like vesicles in a thermal diffusion column. J Am Chem Soc. 2009 Jul 22; 131(28):9628-9. PMID: 19601679; PMCID: PMC2710859.
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  87. Szostak JW. Origins of life: Systems chemistry on early Earth. Nature. 2009 May 14; 459(7244):171-2. PMID: 19444196.
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  88. Zhu TF, Szostak JW. Coupled growth and division of model protocell membranes. J Am Chem Soc. 2009 Apr 22; 131(15):5705-13. PMID: 19323552; PMCID: PMC2669828.
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  89. Litovchick A, Szostak JW. Retraction for Litovchick and Szostak. "Selection of cyclic peptide aptamers to HCV IRES RNA using mRNA display". Proc Natl Acad Sci U S A. 2009 Apr 28; 106(17):7263. PMID: 19380733; PMCID: PMC2678432.
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  90. Zhu TF, Szostak JW. Preparation of large monodisperse vesicles. PLoS One. 2009; 4(4):e5009. PMID: 19347043; PMCID: PMC2661144.
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  91. Chen JJ, Tsai CH, Cai X, Horhota AT, McLaughlin LW, Szostak JW. Enzymatic primer-extension with glycerol-nucleoside triphosphates on DNA templates. PLoS One. 2009; 4(3):e4949. PMID: 19305495; PMCID: PMC2654545.
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  92. Chen JJ, Cai X, Szostak JW. N2'-->p3' phosphoramidate glycerol nucleic acid as a potential alternative genetic system. J Am Chem Soc. 2009 Feb 18; 131(6):2119-21. PMID: 19166350; PMCID: PMC2722806.
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  93. Szostak J. Ray Wu, as remembered by a former student. Sci China C Life Sci. 2009 Feb; 52(2):108-10. PMID: 19277516.
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  94. Litovchick A, Szostak JW. Selection of cyclic peptide aptamers to HCV IRES RNA using mRNA display. Proc Natl Acad Sci U S A. 2008 Oct 07; 105(40):15293-8. PMID: 18824687; PMCID: PMC2556359.
    View in: PubMed, PubMed Central
  95. Mansy SS, Szostak JW. Thermostability of model protocell membranes. Proc Natl Acad Sci U S A. 2008 Sep 09; 105(36):13351-5. PMID: 18768808; PMCID: PMC2528865.
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  96. Mansy SS, Schrum JP, Krishnamurthy M, Tobé S, Treco DA, Szostak JW. Template-directed synthesis of a genetic polymer in a model protocell. Nature. 2008 Jul 03; 454(7200):122-5. PMID: 18528332; PMCID: PMC2743009.
    View in: PubMed, PubMed Central
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  175. Lauhon CT, Szostak JW. RNA aptamers that bind flavin and nicotinamide redox cofactors. J Am Chem Soc. 1995 Feb 01; 117(4):1246-57. PMID: 11539282.
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  209. Park EC, Szostak JW. Point mutations in the yeast histone H4 gene prevent silencing of the silent mating type locus HML. Mol Cell Biol. 1990 Sep; 10(9):4932-4. PMID: 2117703; PMCID: PMC361112.
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  210. Ellington AD, Szostak JW. In vitro selection of RNA molecules that bind specific ligands. Nature. 1990 Aug 30; 346(6287):818-22. PMID: 1697402.
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  211. Doudna JA, Szostak JW. Miniribozymes, small derivatives of the sunY intron, are catalytically active. Mol Cell Biol. 1989 Dec; 9(12):5480-3. PMID: 2685567; PMCID: PMC363717.
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  212. Michel F, Hanna M, Green R, Bartel DP, Szostak JW. The guanosine binding site of the Tetrahymena ribozyme. Nature. 1989 Nov 23; 342(6248):391-5. PMID: 2685606.
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  213. Doudna JA, Cormack BP, Szostak JW. RNA structure, not sequence, determines the 5' splice-site specificity of a group I intron. Proc Natl Acad Sci U S A. 1989 Oct; 86(19):7402-6. PMID: 2678103; PMCID: PMC298070.
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  214. Doudna JA, Szostak JW. RNA-catalysed synthesis of complementary-strand RNA. Nature. 1989 Jun 15; 339(6225):519-22. PMID: 2660003.
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  215. Lundblad V, Szostak JW. A mutant with a defect in telomere elongation leads to senescence in yeast. Cell. 1989 May 19; 57(4):633-43. PMID: 2655926.
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  216. Rajagopal J, Doudna JA, Szostak JW. Stereochemical course of catalysis by the Tetrahymena ribozyme. Science. 1989 May 12; 244(4905):692-4. PMID: 2470151.
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  217. Nicolas A, Treco D, Schultes NP, Szostak JW. An initiation site for meiotic gene conversion in the yeast Saccharomyces cerevisiae. Nature. 1989 Mar 02; 338(6210):35-9. PMID: 2537472.
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  218. Sun H, Treco D, Schultes NP, Szostak JW. Double-strand breaks at an initiation site for meiotic gene conversion. Nature. 1989 Mar 02; 338(6210):87-90. PMID: 2645528.
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  219. Szostak JW. Telomerase: the beginning of the ends. Nature. 1989 Jan 26; 337(6205):303-4. PMID: 2765013.
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  220. Orr-Weaver TL, Nicolas A, Szostak JW. Gene conversion adjacent to regions of double-strand break repair. Mol Cell Biol. 1988 Dec; 8(12):5292-8. PMID: 3072478; PMCID: PMC365631.
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  221. Murray AW, Claus TE, Szostak JW. Characterization of two telomeric DNA processing reactions in Saccharomyces cerevisiae. Mol Cell Biol. 1988 Nov; 8(11):4642-50. PMID: 3062364; PMCID: PMC365553.
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  222. Allshire RC, Gosden JR, Cross SH, Cranston G, Rout D, Sugawara N, Szostak JW, Fantes PA, Hastie ND. Telomeric repeat from T. thermophila cross hybridizes with human telomeres. Nature. 1988 Apr 14; 332(6165):656-9. PMID: 2833706.
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  223. Matsumoto T, Fukui K, Niwa O, Sugawara N, Szostak JW, Yanagida M. Identification of healed terminal DNA fragments in linear minichromosomes of Schizosaccharomyces pombe. Mol Cell Biol. 1987 Dec; 7(12):4424-30. PMID: 2830493; PMCID: PMC368126.
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  224. Murray AW, Szostak JW. Artificial chromosomes. Sci Am. 1987 Nov; 257(5):62-8. PMID: 3317814.
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  225. Reynolds AE, Murray AW, Szostak JW. Roles of the 2 microns gene products in stable maintenance of the 2 microns plasmid of Saccharomyces cerevisiae. Mol Cell Biol. 1987 Oct; 7(10):3566-73. PMID: 3316982; PMCID: PMC368010.
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  226. Whiteway M, Freedman R, Van Arsdell S, Szostak JW, Thorner J. The yeast ARD1 gene product is required for repression of cryptic mating-type information at the HML locus. Mol Cell Biol. 1987 Oct; 7(10):3713-22. PMID: 3316986; PMCID: PMC368027.
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  227. Burke JM, Belfort M, Cech TR, Davies RW, Schweyen RJ, Shub DA, Szostak JW, Tabak HF. Structural conventions for group I introns. Nucleic Acids Res. 1987 Sep 25; 15(18):7217-21. PMID: 3658691; PMCID: PMC306243.
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  228. Doudna JA, Gerber AS, Cherry JM, Szostak JW. Genetic dissection of an RNA enzyme. Cold Spring Harb Symp Quant Biol. 1987; 52:173-80. PMID: 2456876.
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  229. Dawson DS, Murray AW, Szostak JW. An alternative pathway for meiotic chromosome segregation in yeast. Science. 1986 Nov 07; 234(4777):713-7. PMID: 3535068.
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  230. Murray AW, Szostak JW. Construction and behavior of circularly permuted and telocentric chromosomes in Saccharomyces cerevisiae. Mol Cell Biol. 1986 Sep; 6(9):3166-72. PMID: 3537731; PMCID: PMC367052.
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  231. Szostak JW. Enzymatic activity of the conserved core of a group I self-splicing intron. Nature. 1986 Jul 3-9; 322(6074):83-6. PMID: 3014350.
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  232. Murray AW, Schultes NP, Szostak JW. Chromosome length controls mitotic chromosome segregation in yeast. Cell. 1986 May 23; 45(4):529-36. PMID: 3518944.
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  233. Whiteway M, Szostak JW. The ARD1 gene of yeast functions in the switch between the mitotic cell cycle and alternative developmental pathways. Cell. 1985 Dec; 43(2 Pt 1):483-92. PMID: 3907857.
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  234. Orr-Weaver TL, Szostak JW. Fungal recombination. Microbiol Rev. 1985 Mar; 49(1):33-58. PMID: 3884994; PMCID: PMC373016.
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  235. Murray AW, Szostak JW. Chromosome segregation in mitosis and meiosis. Annu Rev Cell Biol. 1985; 1:289-315. PMID: 3916318.
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  236. Ruby SW, Szostak JW. Specific Saccharomyces cerevisiae genes are expressed in response to DNA-damaging agents. Mol Cell Biol. 1985 Jan; 5(1):75-84. PMID: 3920512; PMCID: PMC366680.
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  237. Dunn B, Szauter P, Pardue ML, Szostak JW. Transfer of yeast telomeres to linear plasmids by recombination. Cell. 1984 Nov; 39(1):191-201. PMID: 6091911.
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  238. Shampay J, Szostak JW, Blackburn EH. DNA sequences of telomeres maintained in yeast. Nature. 1984 Jul 12-18; 310(5973):154-7. PMID: 6330571.
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  239. Murray AW, Szostak JW. Pedigree analysis of plasmid segregation in yeast. Cell. 1983 Oct; 34(3):961-70. PMID: 6354471.
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  240. Murray AW, Szostak JW. Construction of artificial chromosomes in yeast. Nature. 1983 Sep 15-21; 305(5931):189-93. PMID: 6350893.
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  241. Sugawara N, Szostak JW. Recombination between sequences in nonhomologous positions. Proc Natl Acad Sci U S A. 1983 Sep; 80(18):5675-9. PMID: 6351064; PMCID: PMC384321.
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  242. Orr-Weaver TL, Szostak JW. Yeast recombination: the association between double-strand gap repair and crossing-over. Proc Natl Acad Sci U S A. 1983 Jul; 80(14):4417-21. PMID: 6308623; PMCID: PMC384049.
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  243. Szostak JW, Orr-Weaver TL, Rothstein RJ, Stahl FW. The double-strand-break repair model for recombination. Cell. 1983 May; 33(1):25-35. PMID: 6380756.
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  244. Orr-Weaver TL, Szostak JW. Multiple, tandem plasmid integration in Saccharomyces cerevisiae. Mol Cell Biol. 1983 Apr; 3(4):747-9. PMID: 6343844; PMCID: PMC368590.
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  245. Walmsley RM, Szostak JW, Petes TD. Is there left-handed DNA at the ends of yeast chromosomes? Nature. 1983 Mar 03; 302(5903):84-6. PMID: 6338397.
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  246. Brown PA, Szostak JW. Yeast vectors with negative selection. Methods Enzymol. 1983; 101:278-90. PMID: 6310330.
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  247. Ruby SW, Szostak JW, Murray AW. Cloning regulated yeast genes from a pool of lacZ fusions. Methods Enzymol. 1983; 101:253-69. PMID: 6310328.
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  248. Sugawara N, Szostak JW. Construction of specific chromosomal rearrangements in yeast. Methods Enzymol. 1983; 101:269-78. PMID: 6310329.
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  249. Orr-Weaver TL, Szostak JW, Rothstein RJ. Genetic applications of yeast transformation with linear and gapped plasmids. Methods Enzymol. 1983; 101:228-45. PMID: 6310326.
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  250. Szostak JW. Replication and resolution of telomeres in yeast. Cold Spring Harb Symp Quant Biol. 1983; 47 Pt 2:1187-94. PMID: 6305577.
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  251. Szostak JW. A rapid procedure for the construction of linear yeast plasmids. Methods Enzymol. 1983; 101:245-52. PMID: 6310327.
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  252. Szostak JW, Blackburn EH. Cloning yeast telomeres on linear plasmid vectors. Cell. 1982 May; 29(1):245-55. PMID: 6286143.
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  253. Orr-Weaver TL, Szostak JW, Rothstein RJ. Yeast transformation: a model system for the study of recombination. Proc Natl Acad Sci U S A. 1981 Oct; 78(10):6354-8. PMID: 6273866; PMCID: PMC349037.
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  254. Stiles JI, Szostak JW, Young AT, Wu R, Consaul S, Sherman F. DNA sequence of a mutation in the leader region of the yeast iso-1-cytochrome c mRNA. Cell. 1981 Jul; 25(1):277-84. PMID: 6268305.
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  255. Szostak JW, Wu R. Unequal crossing over in the ribosomal DNA of Saccharomyces cerevisiae. Nature. 1980 Apr 03; 284(5755):426-30. PMID: 6987539.
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  256. Szostak JW, Wu R. Insertion of a genetic marker into the ribosomal DNA of yeast. Plasmid. 1979 Oct; 2(4):536-54. PMID: 394173.
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  257. Szostak JW, Stiles JI, Tye BK, Chiu P, Sherman F, Wu R. Hybridization with synthetic oligonucleotides. Methods Enzymol. 1979; 68:419-28. PMID: 161605.
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  258. Szostak J. [The system of measures and dosages in the 1st Polish herbaries]. Arch Hist Med (Warsz). 1978; 41(1):9-31. PMID: 350187.
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  259. Szostak JW, Stiles JI, Bahl CP, Wu R. Specific binding of a synthetic oligodeoxyribonucleotide to yeast cytochrome c mRNA. Nature. 1977 Jan 06; 265(5589):61-3. PMID: 189200.
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  260. Szostak J. [Authors of the 1st Polish herbal: Stefan Falimirz, Hieronim Spiczynski, Marcin Siennik]. Arch Hist Med (Warsz). 1977; 40(3):277-89. PMID: 337926.
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  261. Szostak J. [Origins of Polish literature on medical pharmaceutics]. Arch Hist Med (Warsz). 1976; 39(4):389-404. PMID: 795393.
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  262. Benham S, Esping C, Masonhall W, Szostak J. Students' eye view of occupational health nursing. Occup Health Nurs. 1972 Aug; 20(8):7-8. PMID: 5065052.
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.