Harvard Catalyst Profiles

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Jack William Szostak, Ph.D.

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  1. R01GM053936 (SZOSTAK, JACK W) Jun 1, 1996 - Jun 30, 2005
    NIH/NIGMS
    IN VITRO EVOLUTION OF NEW MOLECULAR FUNCTIONS
    Role: Principal Investigator
  2. R01GM045315 (SZOSTAK, JACK W) Jul 1, 1991 - Jun 30, 1995
    NIH/NIGMS
    RIBOZYME-SUBSTRATE INTERACTIONS
    Role: Principal Investigator
  3. T32CA009595 (HARLOW, EDWARD E) Aug 1, 1989 - Jun 30, 2005
    NIH/NCI
    GENETICS OF CANCER AND INHERITED DISEASES
    Role: Co-Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Kim SC, Zhou L, Zhang W, O'Flaherty DK, Rondo-Brovetto V, Szostak JW. A Model for the Emergence of RNA from a Prebiotically Plausible Mixture of Ribonucleotides, Arabinonucleotides, and 2'-Deoxynucleotides. J Am Chem Soc. 2020 Feb 05; 142(5):2317-2326. PMID: 31913615.
    Citations:    
  2. Chizzolini F, Passalacqua LFM, Oumais M, Dingilian AI, Szostak JW, Lupták A. Large Phenotypic Enhancement of Structured Random RNA Pools. J Am Chem Soc. 2020 Jan 29; 142(4):1941-1951. PMID: 31887027.
    Citations:    
  3. Zhou L, Kim SC, Ho KH, O'Flaherty DK, Giurgiu C, Wright TH, Szostak JW. Non-enzymatic primer extension with strand displacement. Elife. 2019 11 08; 8. PMID: 31702557.
    Citations:    
  4. Wright TH, Giurgiu C, Zhang W, Radakovic A, O'Flaherty DK, Zhou L, Szostak JW. Prebiotically Plausible "Patching" of RNA Backbone Cleavage through a 3'-5' Pyrophosphate Linkage. J Am Chem Soc. 2019 Nov 13; 141(45):18104-18112. PMID: 31651170.
    Citations:    
  5. Lelyveld VS, O'Flaherty DK, Zhou L, Izgu EC, Szostak JW. DNA polymerase activity on synthetic N3'?P5' phosphoramidate DNA templates. Nucleic Acids Res. 2019 09 26; 47(17):8941-8949. PMID: 31428779.
    Citations:    
  6. Todd ZR, Szabla R, Szostak JW, Sasselov DD. UV photostability of three 2-aminoazoles with key roles in prebiotic chemistry on the early earth. Chem Commun (Camb). 2019 Aug 27; 55(70):10388-10391. PMID: 31380533.
    Citations:    
  7. Zhang W, Pal A, Ricardo A, Szostak JW. Template-Directed Nonenzymatic Primer Extension Using 2-Methylimidazole-Activated Morpholino Derivatives of Guanosine and Cytidine. J Am Chem Soc. 2019 Jul 31; 141(30):12159-12166. PMID: 31298852.
    Citations:    
  8. Walton T, Zhang W, Li L, Tam CP, Szostak JW. The Mechanism of Nonenzymatic Template Copying with Imidazole-Activated Nucleotides. Angew Chem Int Ed Engl. 2019 Aug 05; 58(32):10812-10819. PMID: 30908802.
    Citations:    
  9. O'Flaherty DK, Zhou L, Szostak JW. Nonenzymatic Template-Directed Synthesis of Mixed-Sequence 3'-NP-DNA up to 25 Nucleotides Long Inside Model Protocells. J Am Chem Soc. 2019 Jul 03; 141(26):10481-10488. PMID: 31180644.
    Citations:    
  10. Strom KR, Szostak JW, Prywes N. Transfer of Sequence Information and Replication of Diimine Duplexes. J Org Chem. 2019 Apr 05; 84(7):3754-3761. PMID: 30855962.
    Citations:    
  11. Matsushita-Ishiodori Y, Hanczyc MM, Wang A, Szostak JW, Yomo T. Using Imaging Flow Cytometry to Quantify and Optimize Giant Vesicle Production by Water-in-oil Emulsion Transfer Methods. Langmuir. 2019 Feb 12; 35(6):2375-2382. PMID: 30645943.
    Citations:    Fields:    
  12. Wang A, Chan Miller C, Szostak JW. Core-Shell Modeling of Light Scattering by Vesicles: Effect of Size, Contents, and Lamellarity. Biophys J. 2019 02 19; 116(4):659-669. PMID: 30686489.
    Citations:    Fields:    
  13. Walton T, Pazienza L, Szostak JW. Template-Directed Catalysis of a Multistep Reaction Pathway for Nonenzymatic RNA Primer Extension. Biochemistry. 2019 02 12; 58(6):755-762. PMID: 30566332.
    Citations:    Fields:    
  14. Kim SC, O'Flaherty DK, Zhou L, Lelyveld VS, Szostak JW. Inosine, but none of the 8-oxo-purines, is a plausible component of a primordial version of RNA. Proc Natl Acad Sci U S A. 2018 12 26; 115(52):13318-13323. PMID: 30509978.
    Citations:    Fields:    
  15. Jin L, Engelhart AE, Zhang W, Adamala K, Szostak JW. Catalysis of Template-Directed Nonenzymatic RNA Copying by Iron(II). J Am Chem Soc. 2018 11 07; 140(44):15016-15021. PMID: 30335371.
    Citations:    Fields:    
  16. Joyce GF, Szostak JW. Protocells and RNA Self-Replication. Cold Spring Harb Perspect Biol. 2018 09 04; 10(9). PMID: 30181195.
    Citations:    Fields:    
  17. Giurgiu C, Wright TH, O'Flaherty DK, Szostak JW. A Fluorescent G-Quadruplex Sensor for Chemical RNA Copying. Angew Chem Int Ed Engl. 2018 07 26; 57(31):9844-9848. PMID: 29939457.
    Citations:    Fields:    
  18. Lin S, Liu Q, Lelyveld VS, Choe J, Szostak JW, Gregory RI. Mettl1/Wdr4-Mediated m7G tRNA Methylome Is Required for Normal mRNA Translation and Embryonic Stem Cell Self-Renewal and Differentiation. Mol Cell. 2018 07 19; 71(2):244-255.e5. PMID: 29983320.
    Citations:    Fields:    
  19. Zhang W, Walton T, Li L, Szostak JW. Crystallographic observation of nonenzymatic RNA primer extension. Elife. 2018 05 31; 7. PMID: 29851379.
    Citations:    Fields:    
  20. Szostak J. How Did Life Begin? Sci Am. 2018 May 15; 318(6):65-67. PMID: 29949547.
    Citations:    Fields:    
  21. Szostak J. How Did Life Begin? Nature. 2018 05; 557(7704):S13-S15. PMID: 29743709.
    Citations:    Fields:    Translation:HumansAnimalsCells
  22. O'Flaherty DK, Kamat NP, Mirza FN, Li L, Prywes N, Szostak JW. Copying of Mixed-Sequence RNA Templates inside Model Protocells. J Am Chem Soc. 2018 04 18; 140(15):5171-5178. PMID: 29608310.
    Citations:    Fields:    Translation:Cells
  23. Jin L, Kamat NP, Jena S, Szostak JW. Fatty Acid/Phospholipid Blended Membranes: A Potential Intermediate State in Protocellular Evolution. Small. 2018 04; 14(15):e1704077. PMID: 29479815.
    Citations:    Fields:    
  24. Zhang W, Tam CP, Zhou L, Oh SS, Wang J, Szostak JW. Structural Rationale for the Enhanced Catalysis of Nonenzymatic RNA Primer Extension by a Downstream Oligonucleotide. J Am Chem Soc. 2018 02 28; 140(8):2829-2840. PMID: 29411978.
    Citations: 1     Fields:    Translation:Cells
  25. Jin L, Engelhart AE, Adamala KP, Szostak JW. Preparation, Purification, and Use of Fatty Acid-containing Liposomes. J Vis Exp. 2018 02 09; (132). PMID: 29553563.
    Citations:    Fields:    
  26. Todd ZR, Fahrenbach AC, Magnani CJ, Ranjan S, Björkbom A, Szostak JW, Sasselov DD. Solvated-electron production using cyanocuprates is compatible with the UV-environment on a Hadean-Archaean Earth. Chem Commun (Camb). 2018 Jan 25; 54(9):1121-1124. PMID: 29334083.
    Citations: 2     Fields:    
  27. Tam CP, Zhou L, Fahrenbach AC, Zhang W, Walton T, Szostak JW. Synthesis of a Nonhydrolyzable Nucleotide Phosphoroimidazolide Analogue That Catalyzes Nonenzymatic RNA Primer Extension. J Am Chem Soc. 2018 01 17; 140(2):783-792. PMID: 29251930.
    Citations:    Fields:    Translation:Cells
  28. Jia TZ, Fahrenbach AC, Kamat NP, Adamala KP, Szostak JW. Retraction: Oligoarginine peptides slow strand annealing and assist non-enzymatic RNA replication. Nat Chem. 2017 11 23; 9(12):1286. PMID: 29168488.
    Citations:    Fields:    
  29. Giurgiu C, Li L, O'Flaherty DK, Tam CP, Szostak JW. A Mechanistic Explanation for the Regioselectivity of Nonenzymatic RNA Primer Extension. J Am Chem Soc. 2017 11 22; 139(46):16741-16747. PMID: 29112424.
    Citations:    Fields:    Translation:Cells
  30. Walton T, Szostak JW. A Kinetic Model of Nonenzymatic RNA Polymerization by Cytidine-5'-phosphoro-2-aminoimidazolide. Biochemistry. 2017 10 31; 56(43):5739-5747. PMID: 29022704.
    Citations: 2     Fields:    
  31. Ransey E, Björkbom A, Lelyveld VS, Biecek P, Pantano L, Szostak JW, Sliz P. Comparative analysis of LIN28-RNA binding sites identified at single nucleotide resolution. RNA Biol. 2017 12 02; 14(12):1756-1765. PMID: 28945502.
    Citations: 1     Fields:    Translation:HumansCells
  32. Greider C, Hopkins N, Steitz J, Amon A, Asai D, Barres B, Bass B, Bassler B, Birgeneau R, Bjorkman P, Botchan M, Brugge J, Cech T, Colwell R, Craig N, deLange T, Eisen M, Gottesman S, Green R, Handelsman J, Kimble J, King MC, Lehmann R, Marder E, Mullins D, O'Shea E, Schmid S, Seydoux G, Spradling A, Storz G, Szostak J, Telesnitsky A, Tilghman S, Tjian R, Vale R, Wolberger C, Zakian V. Not just Salk. Science. 2017 09 15; 357(6356):1105-1106. PMID: 28912235.
    Citations:    Fields:    
  33. Szostak JW. The Narrow Road to the Deep Past: In Search of the Chemistry of the Origin of Life. Angew Chem Int Ed Engl. 2017 09 04; 56(37):11037-11043. PMID: 28514493.
    Citations: 3     Fields:    
  34. Bonfio C, Valer L, Scintilla S, Shah S, Evans DJ, Jin L, Szostak JW, Sasselov DD, Sutherland JD, Mansy SS. UV-light-driven prebiotic synthesis of iron-sulfur clusters. Nat Chem. 2017 12; 9(12):1229-1234. PMID: 29168482.
    Citations: 1     Fields:    
  35. Zhang W, Tam CP, Walton T, Fahrenbach AC, Birrane G, Szostak JW. Insight into the mechanism of nonenzymatic RNA primer extension from the structure of an RNA-GpppG complex. Proc Natl Acad Sci U S A. 2017 07 18; 114(29):7659-7664. PMID: 28673998.
    Citations: 1     Fields:    Translation:Cells
  36. Fahrenbach AC, Giurgiu C, Tam CP, Li L, Hongo Y, Aono M, Szostak JW. Common and Potentially Prebiotic Origin for Precursors of Nucleotide Synthesis and Activation. J Am Chem Soc. 2017 07 05; 139(26):8780-8783. PMID: 28640999.
    Citations: 3     Fields:    Translation:Cells
  37. Stairs S, Nikmal A, Bucar DK, Zheng SL, Szostak JW, Powner MW. Divergent prebiotic synthesis of pyrimidine and 8-oxo-purine ribonucleotides. Nat Commun. 2017 05 19; 8:15270. PMID: 28524845.
    Citations: 4     Fields:    Translation:Cells
  38. Li L, Prywes N, Tam CP, O'Flaherty DK, Lelyveld VS, Izgu EC, Pal A, Szostak JW. Enhanced Nonenzymatic RNA Copying with 2-Aminoimidazole Activated Nucleotides. J Am Chem Soc. 2017 02 08; 139(5):1810-1813. PMID: 28117989.
    Citations: 10     Fields:    
  39. Tam CP, Fahrenbach AC, Björkbom A, Prywes N, Izgu EC, Szostak JW. Downstream Oligonucleotides Strongly Enhance the Affinity of GMP to RNA Primer-Template Complexes. J Am Chem Soc. 2017 01 18; 139(2):571-574. PMID: 28055190.
    Citations: 3     Fields:    Translation:Cells
  40. Izgu EC, Björkbom A, Kamat NP, Lelyveld VS, Zhang W, Jia TZ, Szostak JW. N-Carboxyanhydride-Mediated Fatty Acylation of Amino Acids and Peptides for Functionalization of Protocell Membranes. J Am Chem Soc. 2016 12 28; 138(51):16669-16676. PMID: 27959544.
    Citations:    Fields:    Translation:Cells
  41. Zhang W, Tam CP, Wang J, Szostak JW. Unusual Base-Pairing Interactions in Monomer-Template Complexes. ACS Cent Sci. 2016 Dec 28; 2(12):916-926. PMID: 28058281.
    Citations: 1     
  42. Pal A, Das RS, Zhang W, Lang M, McLaughlin LW, Szostak JW. Effect of terminal 3'-hydroxymethyl modification of an RNA primer on nonenzymatic primer extension. Chem Commun (Camb). 2016 Sep 29; 52(80):11905-11907. PMID: 27722518.
    Citations:    Fields:    
  43. Walton T, Szostak JW. A Highly Reactive Imidazolium-Bridged Dinucleotide Intermediate in Nonenzymatic RNA Primer Extension. J Am Chem Soc. 2016 09 14; 138(36):11996-2002. PMID: 27552367.
    Citations: 7     Fields:    Translation:Cells
  44. Prywes N, Blain JC, Del Frate F, Szostak JW. Nonenzymatic copying of RNA templates containing all four letters is catalyzed by activated oligonucleotides. Elife. 2016 06 28; 5. PMID: 27351102.
    Citations: 7     Fields:    Translation:Cells
  45. Jia TZ, Fahrenbach AC, Kamat NP, Adamala KP, Szostak JW. Oligoarginine peptides slow strand annealing and assist non-enzymatic RNA replication. Nat Chem. 2016 10; 8(10):915-21. PMID: 27657866.
    Citations: 6     Fields:    
  46. Prywes N, Michaels YS, Pal A, Oh SS, Szostak JW. Thiolated uridine substrates and templates improve the rate and fidelity of ribozyme-catalyzed RNA copying. Chem Commun (Camb). 2016 May 05; 52(39):6529-32. PMID: 27109314.
    Citations:    Fields:    Translation:Cells
  47. Adamala KP, Engelhart AE, Szostak JW. Collaboration between primitive cell membranes and soluble catalysts. Nat Commun. 2016 Mar 21; 7:11041. PMID: 26996603.
    Citations: 5     Fields:    Translation:Cells
  48. Li L, Lelyveld VS, Prywes N, Szostak JW. Experimental and Computational Evidence for a Loose Transition State in Phosphoroimidazolide Hydrolysis. J Am Chem Soc. 2016 Mar 30; 138(12):3986-9. PMID: 26974265.
    Citations: 1     Fields:    Translation:Cells
  49. Engelhart AE, Adamala KP, Szostak JW. A simple physical mechanism enables homeostasis in primitive cells. Nat Chem. 2016 05; 8(5):448-53. PMID: 27102678.
    Citations: 8     Fields:    
  50. Izgu EC, Oh SS, Szostak JW. Synthesis of activated 3'-amino-3'-deoxy-2-thio-thymidine, a superior substrate for the nonenzymatic copying of nucleic acid templates. Chem Commun (Camb). 2016 Mar 04; 52(18):3684-6. PMID: 26857159.
    Citations:    Fields:    Translation:Cells
  51. Szostak JW. On the origin of life. Medicina (B Aires). 2016; 76(4):199-203. PMID: 27576276.
    Citations:    Fields:    Translation:Cells
  52. Lelyveld VS, Björkbom A, Ransey EM, Sliz P, Szostak JW. Pinpointing RNA-Protein Cross-Links with Site-Specific Stable Isotope-Labeled Oligonucleotides. J Am Chem Soc. 2015 Dec 16; 137(49):15378-81. PMID: 26583201.
    Citations: 2     Fields:    Translation:Cells
  53. Björkbom A, Lelyveld VS, Zhang S, Zhang W, Tam CP, Blain JC, Szostak JW. Bidirectional Direct Sequencing of Noncanonical RNA by Two-Dimensional Analysis of Mass Chromatograms. J Am Chem Soc. 2015 Nov 18; 137(45):14430-8. PMID: 26495937.
    Citations: 2     Fields:    Translation:Cells
  54. Larsen AT, Fahrenbach AC, Sheng J, Pian J, Szostak JW. Thermodynamic insights into 2-thiouridine-enhanced RNA hybridization. Nucleic Acids Res. 2015 Sep 18; 43(16):7675-87. PMID: 26240387.
    Citations: 5     Fields:    Translation:Cells
  55. Kamat NP, Tobé S, Hill IT, Szostak JW. Electrostatic Localization of RNA to Protocell Membranes by Cationic Hydrophobic Peptides. Angew Chem Int Ed Engl. 2015 Sep 28; 54(40):11735-9. PMID: 26223820.
    Citations: 3     Fields:    Translation:Cells
  56. Adamala K, Engelhart AE, Kamat NP, Jin L, Szostak JW. Construction of a liposome dialyzer for the preparation of high-value, small-volume liposome formulations. Nat Protoc. 2015 Jun; 10(6):927-38. PMID: 26020615.
    Citations: 3     Fields:    Translation:Cells
  57. Izgu EC, Fahrenbach AC, Zhang N, Li L, Zhang W, Larsen AT, Blain JC, Szostak JW. Uncovering the thermodynamics of monomer binding for RNA replication. J Am Chem Soc. 2015 May 20; 137(19):6373-82. PMID: 25901790.
    Citations: 6     Fields:    Translation:Cells
  58. Heuberger BD, Pal A, Del Frate F, Topkar VV, Szostak JW. Replacing uridine with 2-thiouridine enhances the rate and fidelity of nonenzymatic RNA primer extension. J Am Chem Soc. 2015 Feb 25; 137(7):2769-75. PMID: 25654265.
    Citations: 8     Fields:    Translation:Cells
  59. Adamala K, Engelhart AE, Szostak JW. Generation of functional RNAs from inactive oligonucleotide complexes by non-enzymatic primer extension. J Am Chem Soc. 2015 Jan 14; 137(1):483-9. PMID: 25521912.
    Citations: 5     Fields:    Translation:Cells
  60. Hentrich C, Szostak JW. Controlled growth of filamentous fatty acid vesicles under flow. Langmuir. 2014 Dec 16; 30(49):14916-25. PMID: 25402759.
    Citations: 2     Fields:    
  61. Budin I, Prwyes N, Zhang N, Szostak JW. Chain-length heterogeneity allows for the assembly of fatty acid vesicles in dilute solutions. Biophys J. 2014 Oct 07; 107(7):1582-90. PMID: 25296310.
    Citations: 9     Fields:    
  62. Sheng J, Larsen A, Heuberger BD, Blain JC, Szostak JW. Crystal structure studies of RNA duplexes containing s(2)U:A and s(2)U:U base pairs. J Am Chem Soc. 2014 Oct 01; 136(39):13916-24. PMID: 25188906.
    Citations: 8     Fields:    Translation:Cells
  63. Blain JC, Szostak JW. Progress toward synthetic cells. Annu Rev Biochem. 2014; 83:615-40. PMID: 24606140.
    Citations: 32     Fields:    Translation:Cells
  64. Jia TZ, Hentrich C, Szostak JW. Rapid RNA exchange in aqueous two-phase system and coacervate droplets. Orig Life Evol Biosph. 2014 Feb; 44(1):1-12. PMID: 24577897.
    Citations: 8     Fields:    Translation:Cells
  65. Sheng J, Li L, Engelhart AE, Gan J, Wang J, Szostak JW. Structural insights into the effects of 2'-5' linkages on the RNA duplex. Proc Natl Acad Sci U S A. 2014 Feb 25; 111(8):3050-5. PMID: 24516151.
    Citations: 12     Fields:    Translation:Cells
  66. Li L, Szostak JW. The free energy landscape of pseudorotation in 3'-5' and 2'-5' linked nucleic acids. J Am Chem Soc. 2014 Feb 19; 136(7):2858-65. PMID: 24499340.
    Citations: 9     Fields:    Translation:Cells
  67. Blain JC, Ricardo A, Szostak JW. Synthesis and nonenzymatic template-directed polymerization of 2'-amino-2'-deoxythreose nucleotides. J Am Chem Soc. 2014 Feb 05; 136(5):2033-9. PMID: 24409991.
    Citations: 2     Fields:    Translation:Cells
  68. Adamala K, Szostak JW. Nonenzymatic template-directed RNA synthesis inside model protocells. Science. 2013 Nov 29; 342(6162):1098-100. PMID: 24288333.
    Citations: 48     Fields:    Translation:Cells
  69. Josephson K, Ricardo A, Szostak JW. mRNA display: from basic principles to macrocycle drug discovery. Drug Discov Today. 2014 Apr; 19(4):388-99. PMID: 24157402.
    Citations: 17     Fields:    Translation:Cells
  70. Zhang S, Blain JC, Zielinska D, Gryaznov SM, Szostak JW. Fast and accurate nonenzymatic copying of an RNA-like synthetic genetic polymer. Proc Natl Acad Sci U S A. 2013 Oct 29; 110(44):17732-7. PMID: 24101473.
    Citations: 13     Fields:    
  71. Adamala K, Szostak JW. Competition between model protocells driven by an encapsulated catalyst. Nat Chem. 2013 Jun; 5(6):495-501. PMID: 23695631.
    Citations: 41     Fields:    Translation:Cells
  72. Engelhart AE, Powner MW, Szostak JW. Functional RNAs exhibit tolerance for non-heritable 2'-5' versus 3'-5' backbone heterogeneity. Nat Chem. 2013 May; 5(5):390-4. PMID: 23609089.
    Citations: 23     Fields:    Translation:Cells
  73. Zhang S, Zhang N, Blain JC, Szostak JW. Synthesis of N3'-P5'-linked phosphoramidate DNA by nonenzymatic template-directed primer extension. J Am Chem Soc. 2013 Jan 16; 135(2):924-32. PMID: 23252395.
    Citations: 6     Fields:    Translation:Cells
  74. Zhu TF, Budin I, Szostak JW. Preparation of fatty acid or phospholipid vesicles by thin-film rehydration. Methods Enzymol. 2013; 533:267-74. PMID: 24182932.
    Citations:    Fields:    
  75. Zhu TF, Budin I, Szostak JW. Preparation of fatty acid micelles. Methods Enzymol. 2013; 533:283-8. PMID: 24182934.
    Citations:    Fields:    
  76. Zhu TF, Budin I, Szostak JW. Vesicle extrusion through polycarbonate track-etched membranes using a hand-held mini-extruder. Methods Enzymol. 2013; 533:275-82. PMID: 24182933.
    Citations: 3     Fields:    
  77. Budin I, Debnath A, Szostak JW. Concentration-driven growth of model protocell membranes. J Am Chem Soc. 2012 Dec 26; 134(51):20812-9. PMID: 23198690.
    Citations: 17     Fields:    Translation:Cells
  78. Powner MW, Zheng SL, Szostak JW. Multicomponent assembly of proposed DNA precursors in water. J Am Chem Soc. 2012 Aug 22; 134(33):13889-95. PMID: 22839703.
    Citations: 4     Fields:    
  79. Zhu TF, Adamala K, Zhang N, Szostak JW. Photochemically driven redox chemistry induces protocell membrane pearling and division. Proc Natl Acad Sci U S A. 2012 Jun 19; 109(25):9828-32. PMID: 22665773.
    Citations: 11     Fields:    Translation:Cells
  80. Hofmann FT, Szostak JW, Seebeck FP. In vitro selection of functional lantipeptides. J Am Chem Soc. 2012 May 16; 134(19):8038-41. PMID: 22545861.
    Citations: 11     Fields:    Translation:Cells
  81. Schlippe YV, Hartman MC, Josephson K, Szostak JW. In vitro selection of highly modified cyclic peptides that act as tight binding inhibitors. J Am Chem Soc. 2012 Jun 27; 134(25):10469-77. PMID: 22428867.
    Citations: 21     Fields:    Translation:Cells
  82. Zhang N, Zhang S, Szostak JW. Activated ribonucleotides undergo a sugar pucker switch upon binding to a single-stranded RNA template. J Am Chem Soc. 2012 Feb 29; 134(8):3691-4. PMID: 22296305.
    Citations: 11     Fields:    Translation:Cells
  83. Szostak JW. Attempts to define life do not help to understand the origin of life. J Biomol Struct Dyn. 2012; 29(4):599-600. PMID: 22208251.
    Citations: 6     Fields:    
  84. Szostak JW. An optimal degree of physical and chemical heterogeneity for the origin of life? Philos Trans R Soc Lond B Biol Sci. 2011 Oct 27; 366(1580):2894-901. PMID: 21930580.
    Citations: 18     Fields:    Translation:Cells
  85. Trevino SG, Zhang N, Elenko MP, Lupták A, Szostak JW. Evolution of functional nucleic acids in the presence of nonheritable backbone heterogeneity. Proc Natl Acad Sci U S A. 2011 Aug 16; 108(33):13492-7. PMID: 21825162.
    Citations: 13     Fields:    Translation:Cells
  86. Seebeck FP, Ricardo A, Szostak JW. Artificial lantipeptides from in vitro translations. Chem Commun (Camb). 2011 Jun 07; 47(21):6141-3. PMID: 21528125.
    Citations: 9     Fields:    Translation:Cells
  87. Budin I, Szostak JW. Physical effects underlying the transition from primitive to modern cell membranes. Proc Natl Acad Sci U S A. 2011 Mar 29; 108(13):5249-54. PMID: 21402937.
    Citations: 46     Fields:    Translation:Cells
  88. Subtelny AO, Hartman MC, Szostak JW. Optimal codon choice can improve the efficiency and fidelity of N-methyl amino acid incorporation into peptides by in-vitro translation. Angew Chem Int Ed Engl. 2011 Mar 28; 50(14):3164-7. PMID: 21381166.
    Citations: 3     Fields:    Translation:Cells
  89. Powner MW, Sutherland JD, Szostak JW. Chemoselective multicomponent one-pot assembly of purine precursors in water. J Am Chem Soc. 2010 Nov 24; 132(46):16677-88. PMID: 21043502.
    Citations: 26     Fields:    Translation:Cells
  90. Szostak JW. DNA ends: just the beginning (Nobel lecture). Angew Chem Int Ed Engl. 2010 Oct 04; 49(41):7386-404. PMID: 20818632.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  91. Elenko MP, Szostak JW, van Oijen AM. Single-molecule binding experiments on long time scales. Rev Sci Instrum. 2010 Aug; 81(8):083705. PMID: 20815611.
    Citations: 4     Fields:    Translation:Cells
  92. Schrum JP, Zhu TF, Szostak JW. The origins of cellular life. Cold Spring Harb Perspect Biol. 2010 Sep; 2(9):a002212. PMID: 20484387.
    Citations: 27     Fields:    Translation:Cells
  93. Rajamani S, Ichida JK, Antal T, Treco DA, Leu K, Nowak MA, Szostak JW, Chen IA. Effect of stalling after mismatches on the error catastrophe in nonenzymatic nucleic acid replication. J Am Chem Soc. 2010 Apr 28; 132(16):5880-5. PMID: 20359213.
    Citations: 31     Fields:    Translation:Cells
  94. Budin I, Szostak JW. Expanding roles for diverse physical phenomena during the origin of life. Annu Rev Biophys. 2010; 39:245-63. PMID: 20192779.
    Citations: 26     Fields:    Translation:Cells
  95. Bruckner RJ, Mansy SS, Ricardo A, Mahadevan L, Szostak JW. Flip-flop-induced relaxation of bending energy: implications for membrane remodeling. Biophys J. 2009 Dec 16; 97(12):3113-22. PMID: 20006948.
    Citations: 21     Fields:    Translation:AnimalsCells
  96. Schrum JP, Ricardo A, Krishnamurthy M, Blain JC, Szostak JW. Efficient and rapid template-directed nucleic acid copying using 2'-amino-2',3'-dideoxyribonucleoside-5'-phosphorimidazolide monomers. J Am Chem Soc. 2009 Oct 14; 131(40):14560-70. PMID: 19757789.
    Citations: 31     Fields:    
  97. Mansy SS, Szostak JW. Reconstructing the emergence of cellular life through the synthesis of model protocells. Cold Spring Harb Symp Quant Biol. 2009; 74:47-54. PMID: 19734203.
    Citations: 19     Fields:    Translation:Cells
  98. Lin S, Horning DP, Szostak JW, Chaput JC. Conformational analysis of DNA repair intermediates by time-resolved fluorescence spectroscopy. J Phys Chem A. 2009 Sep 03; 113(35):9585-7. PMID: 19673467.
    Citations: 3     Fields:    Translation:Cells
  99. Ricardo A, Szostak JW. Origin of life on earth. Sci Am. 2009 Sep; 301(3):54-61. PMID: 19708528.
    Citations: 9     Fields:    Translation:Cells
  100. Elenko MP, Szostak JW, van Oijen AM. Single-molecule imaging of an in vitro-evolved RNA aptamer reveals homogeneous ligand binding kinetics. J Am Chem Soc. 2009 Jul 29; 131(29):9866-7. PMID: 19572753.
    Citations: 11     Fields:    Translation:Cells
  101. Budin I, Bruckner RJ, Szostak JW. Formation of protocell-like vesicles in a thermal diffusion column. J Am Chem Soc. 2009 Jul 22; 131(28):9628-9. PMID: 19601679.
    Citations: 24     Fields:    Translation:Cells
  102. Szostak JW. Origins of life: Systems chemistry on early Earth. Nature. 2009 May 14; 459(7244):171-2. PMID: 19444196.
    Citations: 14     Fields:    Translation:Cells
  103. Zhu TF, Szostak JW. Coupled growth and division of model protocell membranes. J Am Chem Soc. 2009 Apr 22; 131(15):5705-13. PMID: 19323552.
    Citations: 63     Fields:    Translation:Cells
  104. Litovchick A, Szostak JW. Retraction for Litovchick and Szostak. "Selection of cyclic peptide aptamers to HCV IRES RNA using mRNA display". Proc Natl Acad Sci U S A. 2009 Apr 28; 106(17):7263. PMID: 19380733.
    Citations:    Fields:    
  105. Zhu TF, Szostak JW. Preparation of large monodisperse vesicles. PLoS One. 2009; 4(4):e5009. PMID: 19347043.
    Citations: 17     Fields:    
  106. Chen JJ, Tsai CH, Cai X, Horhota AT, McLaughlin LW, Szostak JW. Enzymatic primer-extension with glycerol-nucleoside triphosphates on DNA templates. PLoS One. 2009; 4(3):e4949. PMID: 19305495.
    Citations: 4     Fields:    Translation:Cells
  107. Chen JJ, Cai X, Szostak JW. N2'-->p3' phosphoramidate glycerol nucleic acid as a potential alternative genetic system. J Am Chem Soc. 2009 Feb 18; 131(6):2119-21. PMID: 19166350.
    Citations: 12     Fields:    
  108. Szostak J. Ray Wu, as remembered by a former student. Sci China C Life Sci. 2009 Feb; 52(2):108-10. PMID: 19277516.
    Citations: 1     Fields:    Translation:Humans
  109. Litovchick A, Szostak JW. Selection of cyclic peptide aptamers to HCV IRES RNA using mRNA display. Proc Natl Acad Sci U S A. 2008 Oct 07; 105(40):15293-8. PMID: 18824687.
    Citations: 1     Fields:    Translation:HumansCells
  110. Mansy SS, Szostak JW. Thermostability of model protocell membranes. Proc Natl Acad Sci U S A. 2008 Sep 09; 105(36):13351-5. PMID: 18768808.
    Citations: 41     Fields:    Translation:Cells
  111. Mansy SS, Schrum JP, Krishnamurthy M, Tobé S, Treco DA, Szostak JW. Template-directed synthesis of a genetic polymer in a model protocell. Nature. 2008 Jul 03; 454(7200):122-5. PMID: 18528332.
    Citations: 127     Fields:    Translation:Cells
  112. Subtelny AO, Hartman MC, Szostak JW. Ribosomal synthesis of N-methyl peptides. J Am Chem Soc. 2008 May 14; 130(19):6131-6. PMID: 18402453.
    Citations: 20     Fields:    Translation:Cells
  113. Monnard PA, Szostak JW. Metal-ion catalyzed polymerization in the eutectic phase in water-ice: a possible approach to template-directed RNA polymerization. J Inorg Biochem. 2008 May-Jun; 102(5-6):1104-11. PMID: 18329104.
    Citations: 13     Fields:    Translation:Cells
  114. Hartman MC, Josephson K, Lin CW, Szostak JW. An expanded set of amino acid analogs for the ribosomal translation of unnatural peptides. PLoS One. 2007 Oct 03; 2(10):e972. PMID: 17912351.
    Citations: 29     Fields:    Translation:Cells
  115. Tsai CH, Chen J, Szostak JW. Enzymatic synthesis of DNA on glycerol nucleic acid templates without stable duplex formation between product and template. Proc Natl Acad Sci U S A. 2007 Sep 11; 104(37):14598-603. PMID: 17785419.
    Citations: 8     Fields:    Translation:Cells
  116. Seelig B, Szostak JW. Selection and evolution of enzymes from a partially randomized non-catalytic scaffold. Nature. 2007 Aug 16; 448(7155):828-31. PMID: 17700701.
    Citations: 49     Fields:    Translation:Cells
  117. Mansy SS, Zhang J, Kümmerle R, Nilsson M, Chou JJ, Szostak JW, Chaput JC. Structure and evolutionary analysis of a non-biological ATP-binding protein. J Mol Biol. 2007 Aug 10; 371(2):501-13. PMID: 17583732.
    Citations: 4     Fields:    Translation:Cells
  118. Smith MD, Rosenow MA, Wang M, Allen JP, Szostak JW, Chaput JC. Structural insights into the evolution of a non-biological protein: importance of surface residues in protein fold optimization. PLoS One. 2007 May 23; 2(5):e467. PMID: 17520026.
    Citations: 3     Fields:    Translation:Cells
  119. Hazen RM, Griffin PL, Carothers JM, Szostak JW. Functional information and the emergence of biocomplexity. Proc Natl Acad Sci U S A. 2007 May 15; 104 Suppl 1:8574-81. PMID: 17494745.
    Citations: 24     Fields:    Translation:Animals
  120. Sam M, Pierce K, Szostak JW, McLaughlin LW. 2',3'-Dideoxy-3'-thionucleoside triphosphates: syntheses and polymerase substrate activities. Org Lett. 2007 Mar 15; 9(6):1161-3. PMID: 17319676.
    Citations: 1     Fields:    Translation:Cells
  121. Horhota AT, Szostak JW, McLaughlin LW. Glycerol nucleoside triphosphates: synthesis and polymerase substrate activities. Org Lett. 2006 Nov 09; 8(23):5345-7. PMID: 17078714.
    Citations: 5     Fields:    Translation:Cells
  122. Blackburn EH, Greider CW, Szostak JW. Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging. Nat Med. 2006 Oct; 12(10):1133-8. PMID: 17024208.
    Citations: 248     Fields:    Translation:HumansAnimalsCells
  123. Salehi-Ashtiani K, Lupták A, Litovchick A, Szostak JW. A genomewide search for ribozymes reveals an HDV-like sequence in the human CPEB3 gene. Science. 2006 Sep 22; 313(5794):1788-92. PMID: 16990549.
    Citations: 93     Fields:    Translation:HumansCells
  124. Hanczyc MM, Mansy SS, Szostak JW. Mineral surface directed membrane assembly. Orig Life Evol Biosph. 2007 Feb; 37(1):67-82. PMID: 16909329.
    Citations: 16     Fields:    Translation:Cells
  125. Carothers JM, Oestreich SC, Szostak JW. Aptamers selected for higher-affinity binding are not more specific for the target ligand. J Am Chem Soc. 2006 Jun 21; 128(24):7929-37. PMID: 16771507.
    Citations: 29     Fields:    Translation:Cells
  126. Seebeck FP, Szostak JW. Ribosomal synthesis of dehydroalanine-containing peptides. J Am Chem Soc. 2006 Jun 07; 128(22):7150-1. PMID: 16734454.
    Citations: 11     Fields:    Translation:Cells
  127. Hartman MC, Josephson K, Szostak JW. Enzymatic aminoacylation of tRNA with unnatural amino acids. Proc Natl Acad Sci U S A. 2006 Mar 21; 103(12):4356-61. PMID: 16537388.
    Citations: 20     Fields:    Translation:Cells
  128. Carothers JM, Davis JH, Chou JJ, Szostak JW. Solution structure of an informationally complex high-affinity RNA aptamer to GTP. RNA. 2006 Apr; 12(4):567-79. PMID: 16510427.
    Citations: 19     Fields:    Translation:Cells
  129. Cho GS, Szostak JW. Directed evolution of ATP binding proteins from a zinc finger domain by using mRNA display. Chem Biol. 2006 Feb; 13(2):139-47. PMID: 16492562.
    Citations: 10     Fields:    Translation:HumansCells
  130. Fujikawa SM, Chen IA, Szostak JW. Shrink-wrap vesicles. Langmuir. 2005 Dec 20; 21(26):12124-9. PMID: 16342983.
    Citations: 5     Fields:    Translation:Cells
  131. Plummer KA, Carothers JM, Yoshimura M, Szostak JW, Verdine GL. In vitro selection of RNA aptamers against a composite small molecule-protein surface. Nucleic Acids Res. 2005; 33(17):5602-10. PMID: 16199752.
    Citations: 2     Fields:    Translation:HumansCells
  132. Chen IA, Salehi-Ashtiani K, Szostak JW. RNA catalysis in model protocell vesicles. J Am Chem Soc. 2005 Sep 28; 127(38):13213-9. PMID: 16173749.
    Citations: 47     Fields:    Translation:Cells
  133. Ichida JK, Horhota A, Zou K, McLaughlin LW, Szostak JW. High fidelity TNA synthesis by Therminator polymerase. Nucleic Acids Res. 2005; 33(16):5219-25. PMID: 16157867.
    Citations: 18     Fields:    
  134. Josephson K, Hartman MC, Szostak JW. Ribosomal synthesis of unnatural peptides. J Am Chem Soc. 2005 Aug 24; 127(33):11727-35. PMID: 16104750.
    Citations: 44     Fields:    Translation:Cells
  135. Horhota A, Zou K, Ichida JK, Yu B, McLaughlin LW, Szostak JW, Chaput JC. Kinetic analysis of an efficient DNA-dependent TNA polymerase. J Am Chem Soc. 2005 May 25; 127(20):7427-34. PMID: 15898792.
    Citations: 18     Fields:    Translation:Cells
  136. Shen X, Valencia CA, Szostak JW, Szostak J, Dong B, Liu R. Scanning the human proteome for calmodulin-binding proteins. Proc Natl Acad Sci U S A. 2005 Apr 26; 102(17):5969-74. PMID: 15840729.
    Citations: 48     Fields:    Translation:HumansCells
  137. Zou K, Horhota A, Yu B, Szostak JW, McLaughlin LW. Synthesis of alpha-L-threofuranosyl nucleoside triphosphates (tNTPs). Org Lett. 2005 Apr 14; 7(8):1485-7. PMID: 15816733.
    Citations: 4     Fields:    Translation:Cells
  138. Sacerdote MG, Szostak JW. Semipermeable lipid bilayers exhibit diastereoselectivity favoring ribose. Proc Natl Acad Sci U S A. 2005 Apr 26; 102(17):6004-8. PMID: 15831588.
    Citations: 28     Fields:    Translation:Cells
  139. Ichida JK, Zou K, Horhota A, Yu B, McLaughlin LW, Szostak JW. An in vitro selection system for TNA. J Am Chem Soc. 2005 Mar 09; 127(9):2802-3. PMID: 15740086.
    Citations: 19     Fields:    Translation:Cells
  140. Hanczyc MM, Szostak JW. Replicating vesicles as models of primitive cell growth and division. Curr Opin Chem Biol. 2004 Dec; 8(6):660-4. PMID: 15556412.
    Citations: 29     Fields:    
  141. Chen IA, Roberts RW, Szostak JW. The emergence of competition between model protocells. Science. 2004 Sep 03; 305(5689):1474-6. PMID: 15353806.
    Citations: 75     Fields:    Translation:Cells
  142. Chen IA, Szostak JW. A kinetic study of the growth of fatty acid vesicles. Biophys J. 2004 Aug; 87(2):988-98. PMID: 15298905.
    Citations: 38     Fields:    
  143. Sazani PL, Larralde R, Szostak JW. A small aptamer with strong and specific recognition of the triphosphate of ATP. J Am Chem Soc. 2004 Jul 14; 126(27):8370-1. PMID: 15237981.
    Citations: 19     Fields:    Translation:Cells
  144. Chaput JC, Szostak JW. Evolutionary optimization of a nonbiological ATP binding protein for improved folding stability. Chem Biol. 2004 Jun; 11(6):865-74. PMID: 15217619.
    Citations: 7     Fields:    Translation:Cells
  145. Chen IA, Szostak JW. Membrane growth can generate a transmembrane pH gradient in fatty acid vesicles. Proc Natl Acad Sci U S A. 2004 May 25; 101(21):7965-70. PMID: 15148394.
    Citations: 37     Fields:    Translation:Cells
  146. Carothers JM, Oestreich SC, Davis JH, Szostak JW. Informational complexity and functional activity of RNA structures. J Am Chem Soc. 2004 Apr 28; 126(16):5130-7. PMID: 15099096.
    Citations: 68     Fields:    Translation:Cells
  147. Huang Z, Szostak JW. Evolution of aptamers with a new specificity and new secondary structures from an ATP aptamer. RNA. 2003 Dec; 9(12):1456-63. PMID: 14624002.
    Citations: 16     Fields:    Translation:Cells
  148. Hanczyc MM, Fujikawa SM, Szostak JW. Experimental models of primitive cellular compartments: encapsulation, growth, and division. Science. 2003 Oct 24; 302(5645):618-22. PMID: 14576428.
    Citations: 129     Fields:    Translation:Cells
  149. Chaput JC, Szostak JW. TNA synthesis by DNA polymerases. J Am Chem Soc. 2003 Aug 06; 125(31):9274-5. PMID: 12889939.
    Citations: 19     Fields:    
  150. Vaish NK, Larralde R, Fraley AW, Szostak JW, McLaughlin LW. A novel, modification-dependent ATP-binding aptamer selected from an RNA library incorporating a cationic functionality. Biochemistry. 2003 Jul 29; 42(29):8842-51. PMID: 12873145.
    Citations: 12     Fields:    Translation: