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Szostak, Jack
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Jack William Szostak, Ph.D.
Title
Professor of Genetics
Institution
Massachusetts General Hospital
Department
Genetics
Address
Massachusetts General Hospital
Simches Research Ctr CPZN# 7320
185 Cambridge St
Boston MA 02114
Phone
617/726-5981
Fax
617/726-6893
vCard
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research activities and funding
|
selected publications
|
Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can
login
to make corrections and additions.
Most Recent
|
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R01GM053936
(SZOSTAK, JACK W)
Jun 1, 1996 - Jun 30, 2005
NIH
IN VITRO EVOLUTION OF NEW MOLECULAR FUNCTIONS
Role: Principal Investigator
R01GM045315
(SZOSTAK, JACK W)
Jul 1, 1991 - Jun 30, 1995
NIH
RIBOZYME-SUBSTRATE INTERACTIONS
Role: Principal Investigator
T32CA009595
(HARLOW, EDWARD E)
Aug 1, 1989 - Aug 31, 1999
NIH
GENETICS OF CANCER AND INHERITED DISEASES
Role: Co-Principal Investigator
Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can
login
to make corrections and additions.
Newest
|
Oldest
|
Most Cited
|
Most Discussed
|
Timeline
|
Field Summary
|
Plain Text
PMC Citations
indicate the number of times the publication was cited by articles in PubMed Central, and the
Altmetric
score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.)
Fields
are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
Translation
tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
Kim SC, O'Flaherty DK, Giurgiu C, Zhou L,
Szostak JW
. The Emergence of RNA from the Heterogeneous Products of Prebiotic Nucleotide Synthesis. J Am Chem Soc. 2021 Mar 10; 143(9):3267-3279.
PMID:
33636080
.
Citations:
Fields:
Che
Chemistry
Mojarro A, Jin L,
Szostak JW
, Head JW, Zuber MT. In search of the RNA world on Mars. Geobiology. 2021 Feb 10.
PMID:
33565260
.
Citations:
Fields:
Bio
Biology
Env
Environmental Health
Radakovic A, Wright TH,
Lelyveld VS
,
Szostak JW
. A Potential Role for Aminoacylation in Primordial RNA Copying Chemistry. Biochemistry. 2021 Feb 16; 60(6):477-488.
PMID:
33523633
.
Citations:
Fields:
Bio
Biochemistry
Zhang W, Kim SC, Tam CP,
Lelyveld VS
, Bala S, Chaput JC,
Szostak JW
. Structural interpretation of the effects of threo-nucleotides on nonenzymatic template-directed polymerization. Nucleic Acids Res. 2021 01 25; 49(2):646-656.
PMID:
33347562
.
Citations:
Fields:
Bio
Biochemistry
Translation:
Cells
Strom KR
,
Szostak JW
. Solid-Phase Synthesis of Sequence-Defined Informational Oligomers. J Org Chem. 2020 11 06; 85(21):13929-13938.
PMID:
33064001
.
Citations:
Fields:
Che
Chemistry
Zhou L, Ding D,
Szostak JW
. The virtual circular genome model for primordial RNA replication. RNA. 2021 Jan; 27(1):1-11.
PMID:
33028653
.
Citations:
Fields:
Mol
Molecular Biology
O'Flaherty DK, Zhou L,
Szostak JW
. Nonenzymatic RNA-templated Synthesis of N3'?P5' Phosphoramidate DNA. Bio Protoc. 2020 Sep 05; 10(17):e3734.
PMID:
33659395
.
Citations:
Zhou L, O'Flaherty DK,
Szostak JW
. Assembly of a Ribozyme Ligase from Short Oligomers by Nonenzymatic Ligation. J Am Chem Soc. 2020 09 16; 142(37):15961-15965.
PMID:
32820909
.
Citations:
3
Fields:
Che
Chemistry
Zhang SJ,
Duzdevich D
,
Szostak JW
. Potentially Prebiotic Activation Chemistry Compatible with Nonenzymatic RNA Copying. J Am Chem Soc. 2020 09 02; 142(35):14810-14813.
PMID:
32794700
.
Citations:
1
Fields:
Che
Chemistry
Zhou L, O'Flaherty DK,
Szostak JW
. Template-Directed Copying of RNA by Non-enzymatic Ligation. Angew Chem Int Ed Engl. 2020 09 01; 59(36):15682-15687.
PMID:
32558121
.
Citations:
3
Fields:
Che
Chemistry
Kindt JT,
Szostak JW
, Wang A. Bulk Self-Assembly of Giant, Unilamellar Vesicles. ACS Nano. 2020 11 24; 14(11):14627-14634.
PMID:
32602696
.
Citations:
Fields:
Nan
Nanotechnology
Duzdevich D
, Carr CE,
Szostak JW
. Deep sequencing of non-enzymatic RNA primer extension. Nucleic Acids Res. 2020 07 09; 48(12):e70.
PMID:
32427335
.
Citations:
Fields:
Bio
Biochemistry
Yildirim O, Izgu EC, Damle M, Chalei V,
Ji F
,
Sadreyev RI
,
Szostak JW
,
Kingston RE
. S-phase Enriched Non-coding RNAs Regulate Gene Expression and Cell Cycle Progression. Cell Rep. 2020 05 12; 31(6):107629.
PMID:
32402276
.
Citations:
1
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Todd ZR, Fahrenbach AC, Ranjan S, Magnani CJ,
Szostak JW
, Sasselov DD. Ultraviolet-Driven Deamination of Cytidine Ribonucleotides Under Planetary Conditions. Astrobiology. 2020 07; 20(7):878-888.
PMID:
32267736
.
Citations:
Fields:
Bio
Biology
Lelyveld VS
, Zhang W,
Szostak JW
. Synthesis of phosphoramidate-linked DNA by a modified DNA polymerase. Proc Natl Acad Sci U S A. 2020 03 31; 117(13):7276-7283.
PMID:
32188786
.
Citations:
2
Fields:
Sci
Science
Translation:
Cells
Walton T
,
DasGupta S
,
Duzdevich D
, Oh SS,
Szostak JW
. In vitro selection of ribozyme ligases that use prebiotically plausible 2-aminoimidazole-activated substrates. Proc Natl Acad Sci U S A. 2020 03 17; 117(11):5741-5748.
PMID:
32123094
.
Citations:
3
Fields:
Sci
Science
Translation:
Cells
Kim SC, Zhou L, Zhang W, O'Flaherty DK, Rondo-Brovetto V,
Szostak JW
. A Model for the Emergence of RNA from a Prebiotically Plausible Mixture of Ribonucleotides, Arabinonucleotides, and 2'-Deoxynucleotides. J Am Chem Soc. 2020 02 05; 142(5):2317-2326.
PMID:
31913615
.
Citations:
3
Fields:
Che
Chemistry
Translation:
Cells
Chizzolini F, Passalacqua LFM, Oumais M, Dingilian AI,
Szostak JW
, Lupták A. Large Phenotypic Enhancement of Structured Random RNA Pools. J Am Chem Soc. 2020 01 29; 142(4):1941-1951.
PMID:
31887027
.
Citations:
Fields:
Che
Chemistry
Translation:
Cells
Wang A,
Szostak JW
. Lipid constituents of model protocell membranes. Emerg Top Life Sci. 2019 Nov 11; 3(5):537-542.
PMID:
33523161
.
Citations:
1
Zhou L, Kim SC, Ho KH, O'Flaherty DK, Giurgiu C, Wright TH,
Szostak JW
. Non-enzymatic primer extension with strand displacement. Elife. 2019 11 08; 8.
PMID:
31702557
.
Citations:
5
Fields:
Bio
Biology
Translation:
Cells
Wright TH, Giurgiu C, Zhang W, Radakovic A, O'Flaherty DK, Zhou L,
Szostak JW
. Prebiotically Plausible "Patching" of RNA Backbone Cleavage through a 3'-5' Pyrophosphate Linkage. J Am Chem Soc. 2019 11 13; 141(45):18104-18112.
PMID:
31651170
.
Citations:
3
Fields:
Che
Chemistry
Translation:
Cells
Lelyveld VS
, O'Flaherty DK, Zhou L, Izgu EC,
Szostak JW
. DNA polymerase activity on synthetic N3'?P5' phosphoramidate DNA templates. Nucleic Acids Res. 2019 09 26; 47(17):8941-8949.
PMID:
31428779
.
Citations:
3
Fields:
Bio
Biochemistry
Translation:
Cells
Todd ZR, Szabla R,
Szostak JW
, Sasselov DD. UV photostability of three 2-aminoazoles with key roles in prebiotic chemistry on the early earth. Chem Commun (Camb). 2019 Aug 27; 55(70):10388-10391.
PMID:
31380533
.
Citations:
3
Fields:
Che
Chemistry
Zhang W, Pal A, Ricardo A,
Szostak JW
. Template-Directed Nonenzymatic Primer Extension Using 2-Methylimidazole-Activated Morpholino Derivatives of Guanosine and Cytidine. J Am Chem Soc. 2019 07 31; 141(30):12159-12166.
PMID:
31298852
.
Citations:
2
Fields:
Che
Chemistry
Translation:
Cells
Walton T
, Zhang W, Li L, Tam CP,
Szostak JW
. The Mechanism of Nonenzymatic Template Copying with Imidazole-Activated Nucleotides. Angew Chem Int Ed Engl. 2019 08 05; 58(32):10812-10819.
PMID:
30908802
.
Citations:
4
Fields:
Che
Chemistry
O'Flaherty DK, Zhou L,
Szostak JW
. Nonenzymatic Template-Directed Synthesis of Mixed-Sequence 3'-NP-DNA up to 25 Nucleotides Long Inside Model Protocells. J Am Chem Soc. 2019 07 03; 141(26):10481-10488.
PMID:
31180644
.
Citations:
7
Fields:
Che
Chemistry
Strom KR
,
Szostak JW
, Prywes N. Transfer of Sequence Information and Replication of Diimine Duplexes. J Org Chem. 2019 04 05; 84(7):3754-3761.
PMID:
30855962
.
Citations:
2
Fields:
Che
Chemistry
Translation:
Cells
Matsushita-Ishiodori Y, Hanczyc MM, Wang A,
Szostak JW
, Yomo T. Using Imaging Flow Cytometry to Quantify and Optimize Giant Vesicle Production by Water-in-oil Emulsion Transfer Methods. Langmuir. 2019 02 12; 35(6):2375-2382.
PMID:
30645943
.
Citations:
2
Fields:
Che
Chemistry
Wang A, Chan Miller C,
Szostak JW
. Core-Shell Modeling of Light Scattering by Vesicles: Effect of Size, Contents, and Lamellarity. Biophys J. 2019 02 19; 116(4):659-669.
PMID:
30686489
.
Citations:
2
Fields:
Bio
Biophysics
Walton T
, Pazienza L,
Szostak JW
. Template-Directed Catalysis of a Multistep Reaction Pathway for Nonenzymatic RNA Primer Extension. Biochemistry. 2019 02 12; 58(6):755-762.
PMID:
30566332
.
Citations:
3
Fields:
Bio
Biochemistry
Translation:
Cells
Kim SC, O'Flaherty DK, Zhou L,
Lelyveld VS
,
Szostak JW
. Inosine, but none of the 8-oxo-purines, is a plausible component of a primordial version of RNA. Proc Natl Acad Sci U S A. 2018 12 26; 115(52):13318-13323.
PMID:
30509978
.
Citations:
11
Fields:
Sci
Science
Translation:
Cells
Jin L, Engelhart AE, Zhang W, Adamala K,
Szostak JW
. Catalysis of Template-Directed Nonenzymatic RNA Copying by Iron(II). J Am Chem Soc. 2018 11 07; 140(44):15016-15021.
PMID:
30335371
.
Citations:
2
Fields:
Che
Chemistry
Translation:
Cells
Joyce GF,
Szostak JW
. Protocells and RNA Self-Replication. Cold Spring Harb Perspect Biol. 2018 09 04; 10(9).
PMID:
30181195
.
Citations:
29
Fields:
Bio
Biology
Translation:
Cells
Giurgiu C, Wright TH, O'Flaherty DK,
Szostak JW
. A Fluorescent G-Quadruplex Sensor for Chemical RNA Copying. Angew Chem Int Ed Engl. 2018 07 26; 57(31):9844-9848.
PMID:
29939457
.
Citations:
2
Fields:
Che
Chemistry
Translation:
Cells
Lin S, Liu Q,
Lelyveld VS
, Choe J,
Szostak JW
,
Gregory RI
. Mettl1/Wdr4-Mediated m7G tRNA Methylome Is Required for Normal mRNA Translation and Embryonic Stem Cell Self-Renewal and Differentiation. Mol Cell. 2018 07 19; 71(2):244-255.e5.
PMID:
29983320
.
Citations:
33
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Zhang W,
Walton T
, Li L,
Szostak JW
. Crystallographic observation of nonenzymatic RNA primer extension. Elife. 2018 05 31; 7.
PMID:
29851379
.
Citations:
7
Fields:
Bio
Biology
Translation:
Cells
Szostak J
. How Did Life Begin? Sci Am. 2018 May 15; 318(6):65-67.
PMID:
29949547
.
Citations:
Fields:
Sci
Science
Szostak J
. How Did Life Begin? Nature. 2018 05; 557(7704):S13-S15.
PMID:
29743709
.
Citations:
1
Fields:
Sci
Science
Translation:
Humans
Animals
Cells
O'Flaherty DK, Kamat NP, Mirza FN, Li L, Prywes N,
Szostak JW
. Copying of Mixed-Sequence RNA Templates inside Model Protocells. J Am Chem Soc. 2018 04 18; 140(15):5171-5178.
PMID:
29608310
.
Citations:
15
Fields:
Che
Chemistry
Translation:
Cells
Jin L, Kamat NP, Jena S,
Szostak JW
. Fatty Acid/Phospholipid Blended Membranes: A Potential Intermediate State in Protocellular Evolution. Small. 2018 04; 14(15):e1704077.
PMID:
29479815
.
Citations:
8
Fields:
Bio
Biomedical Engineering
Nan
Nanotechnology
Zhang W, Tam CP, Zhou L, Oh SS, Wang J,
Szostak JW
. Structural Rationale for the Enhanced Catalysis of Nonenzymatic RNA Primer Extension by a Downstream Oligonucleotide. J Am Chem Soc. 2018 02 28; 140(8):2829-2840.
PMID:
29411978
.
Citations:
7
Fields:
Che
Chemistry
Translation:
Cells
Jin L, Engelhart AE, Adamala KP,
Szostak JW
. Preparation, Purification, and Use of Fatty Acid-containing Liposomes. J Vis Exp. 2018 02 09; (132).
PMID:
29553563
.
Citations:
3
Fields:
Bio
Biology
Med
Medicine (General)
Todd ZR, Fahrenbach AC, Magnani CJ, Ranjan S, Björkbom A,
Szostak JW
, Sasselov DD. Solvated-electron production using cyanocuprates is compatible with the UV-environment on a Hadean-Archaean Earth. Chem Commun (Camb). 2018 Jan 25; 54(9):1121-1124.
PMID:
29334083
.
Citations:
6
Fields:
Che
Chemistry
Tam CP, Zhou L, Fahrenbach AC, Zhang W,
Walton T
,
Szostak JW
. Synthesis of a Nonhydrolyzable Nucleotide Phosphoroimidazolide Analogue That Catalyzes Nonenzymatic RNA Primer Extension. J Am Chem Soc. 2018 01 17; 140(2):783-792.
PMID:
29251930
.
Citations:
1
Fields:
Che
Chemistry
Translation:
Cells
Jia TZ, Fahrenbach AC, Kamat NP, Adamala KP,
Szostak JW
. Retraction: Oligoarginine peptides slow strand annealing and assist non-enzymatic RNA replication. Nat Chem. 2017 11 23; 9(12):1286.
PMID:
29168488
.
Citations:
Fields:
Che
Chemistry
Giurgiu C, Li L, O'Flaherty DK, Tam CP,
Szostak JW
. A Mechanistic Explanation for the Regioselectivity of Nonenzymatic RNA Primer Extension. J Am Chem Soc. 2017 11 22; 139(46):16741-16747.
PMID:
29112424
.
Citations:
7
Fields:
Che
Chemistry
Translation:
Cells
Walton T
,
Szostak JW
. A Kinetic Model of Nonenzymatic RNA Polymerization by Cytidine-5'-phosphoro-2-aminoimidazolide. Biochemistry. 2017 10 31; 56(43):5739-5747.
PMID:
29022704
.
Citations:
12
Fields:
Bio
Biochemistry
Ransey E, Björkbom A,
Lelyveld VS
, Biecek P, Pantano L,
Szostak JW
,
Sliz P
. Comparative analysis of LIN28-RNA binding sites identified at single nucleotide resolution. RNA Biol. 2017 12 02; 14(12):1756-1765.
PMID:
28945502
.
Citations:
4
Fields:
Mol
Molecular Biology
Translation:
Humans
Cells
Greider C, Hopkins N, Steitz J, Amon A, Asai D, Barres B, Bass B, Bassler B, Birgeneau R, Bjorkman P, Botchan M,
Brugge J
, Cech T, Colwell R, Craig N, deLange T, Eisen M, Gottesman S, Green R, Handelsman J, Kimble J, King MC, Lehmann R, Marder E, Mullins D, O'Shea E, Schmid S, Seydoux G, Spradling A, Storz G,
Szostak J
, Telesnitsky A, Tilghman S, Tjian R, Vale R, Wolberger C, Zakian V. Not just Salk. Science. 2017 09 15; 357(6356):1105-1106.
PMID:
28912235
.
Citations:
Fields:
Sci
Science
Szostak JW
. The Narrow Road to the Deep Past: In Search of the Chemistry of the Origin of Life. Angew Chem Int Ed Engl. 2017 09 04; 56(37):11037-11043.
PMID:
28514493
.
Citations:
24
Fields:
Che
Chemistry
Translation:
Cells
Bonfio C, Valer L, Scintilla S, Shah S, Evans DJ, Jin L,
Szostak JW
, Sasselov DD, Sutherland JD, Mansy SS. UV-light-driven prebiotic synthesis of iron-sulfur clusters. Nat Chem. 2017 12; 9(12):1229-1234.
PMID:
29168482
.
Citations:
15
Fields:
Che
Chemistry
Translation:
Cells
Zhang W, Tam CP,
Walton T
, Fahrenbach AC,
Birrane G
,
Szostak JW
. Insight into the mechanism of nonenzymatic RNA primer extension from the structure of an RNA-GpppG complex. Proc Natl Acad Sci U S A. 2017 07 18; 114(29):7659-7664.
PMID:
28673998
.
Citations:
8
Fields:
Sci
Science
Translation:
Cells
Fahrenbach AC, Giurgiu C, Tam CP, Li L, Hongo Y, Aono M,
Szostak JW
. Common and Potentially Prebiotic Origin for Precursors of Nucleotide Synthesis and Activation. J Am Chem Soc. 2017 07 05; 139(26):8780-8783.
PMID:
28640999
.
Citations:
20
Fields:
Che
Chemistry
Translation:
Cells
Stairs S, Nikmal A, Bucar DK, Zheng SL,
Szostak JW
, Powner MW. Divergent prebiotic synthesis of pyrimidine and 8-oxo-purine ribonucleotides. Nat Commun. 2017 05 19; 8:15270.
PMID:
28524845
.
Citations:
21
Fields:
Bio
Biology
Sci
Science
Translation:
Cells
Li L, Prywes N, Tam CP, O'Flaherty DK,
Lelyveld VS
, Izgu EC, Pal A,
Szostak JW
. Enhanced Nonenzymatic RNA Copying with 2-Aminoimidazole Activated Nucleotides. J Am Chem Soc. 2017 02 08; 139(5):1810-1813.
PMID:
28117989
.
Citations:
39
Fields:
Che
Chemistry
Tam CP, Fahrenbach AC, Björkbom A, Prywes N, Izgu EC,
Szostak JW
. Downstream Oligonucleotides Strongly Enhance the Affinity of GMP to RNA Primer-Template Complexes. J Am Chem Soc. 2017 01 18; 139(2):571-574.
PMID:
28055190
.
Citations:
8
Fields:
Che
Chemistry
Translation:
Cells
Izgu EC, Björkbom A, Kamat NP,
Lelyveld VS
, Zhang W, Jia TZ,
Szostak JW
. N-Carboxyanhydride-Mediated Fatty Acylation of Amino Acids and Peptides for Functionalization of Protocell Membranes. J Am Chem Soc. 2016 12 28; 138(51):16669-16676.
PMID:
27959544
.
Citations:
5
Fields:
Che
Chemistry
Translation:
Cells
Zhang W, Tam CP, Wang J,
Szostak JW
. Unusual Base-Pairing Interactions in Monomer-Template Complexes. ACS Cent Sci. 2016 Dec 28; 2(12):916-926.
PMID:
28058281
.
Citations:
9
Pal A, Das RS, Zhang W, Lang M, McLaughlin LW,
Szostak JW
. Effect of terminal 3'-hydroxymethyl modification of an RNA primer on nonenzymatic primer extension. Chem Commun (Camb). 2016 Sep 29; 52(80):11905-11907.
PMID:
27722518
.
Citations:
1
Fields:
Che
Chemistry
Walton T
,
Szostak JW
. A Highly Reactive Imidazolium-Bridged Dinucleotide Intermediate in Nonenzymatic RNA Primer Extension. J Am Chem Soc. 2016 09 14; 138(36):11996-2002.
PMID:
27552367
.
Citations:
25
Fields:
Che
Chemistry
Translation:
Cells
Prywes N, Blain JC, Del Frate F,
Szostak JW
. Nonenzymatic copying of RNA templates containing all four letters is catalyzed by activated oligonucleotides. Elife. 2016 06 28; 5.
PMID:
27351102
.
Citations:
33
Fields:
Bio
Biology
Translation:
Cells
Jia TZ, Fahrenbach AC, Kamat NP, Adamala KP,
Szostak JW
. Oligoarginine peptides slow strand annealing and assist non-enzymatic RNA replication. Nat Chem. 2016 10; 8(10):915-21.
PMID:
27657866
.
Citations:
7
Fields:
Che
Chemistry
Prywes N, Michaels YS, Pal A, Oh SS,
Szostak JW
. Thiolated uridine substrates and templates improve the rate and fidelity of ribozyme-catalyzed RNA copying. Chem Commun (Camb). 2016 May 05; 52(39):6529-32.
PMID:
27109314
.
Citations:
1
Fields:
Che
Chemistry
Translation:
Cells
Adamala KP, Engelhart AE,
Szostak JW
. Collaboration between primitive cell membranes and soluble catalysts. Nat Commun. 2016 Mar 21; 7:11041.
PMID:
26996603
.
Citations:
15
Fields:
Bio
Biology
Sci
Science
Translation:
Cells
Li L,
Lelyveld VS
, Prywes N,
Szostak JW
. Experimental and Computational Evidence for a Loose Transition State in Phosphoroimidazolide Hydrolysis. J Am Chem Soc. 2016 Mar 30; 138(12):3986-9.
PMID:
26974265
.
Citations:
1
Fields:
Che
Chemistry
Translation:
Cells
Engelhart AE, Adamala KP,
Szostak JW
. A simple physical mechanism enables homeostasis in primitive cells. Nat Chem. 2016 05; 8(5):448-53.
PMID:
27102678
.
Citations:
19
Fields:
Che
Chemistry
Izgu EC, Oh SS,
Szostak JW
. Synthesis of activated 3'-amino-3'-deoxy-2-thio-thymidine, a superior substrate for the nonenzymatic copying of nucleic acid templates. Chem Commun (Camb). 2016 Mar 04; 52(18):3684-6.
PMID:
26857159
.
Citations:
2
Fields:
Che
Chemistry
Translation:
Cells
Szostak JW
. On the origin of life. Medicina (B Aires). 2016; 76(4):199-203.
PMID:
27576276
.
Citations:
3
Fields:
Med
Medicine (General)
Translation:
Cells
Lelyveld VS
, Björkbom A, Ransey EM,
Sliz P
,
Szostak JW
. Pinpointing RNA-Protein Cross-Links with Site-Specific Stable Isotope-Labeled Oligonucleotides. J Am Chem Soc. 2015 Dec 16; 137(49):15378-81.
PMID:
26583201
.
Citations:
3
Fields:
Che
Chemistry
Translation:
Cells
Björkbom A,
Lelyveld VS
, Zhang S, Zhang W, Tam CP, Blain JC,
Szostak JW
. Bidirectional Direct Sequencing of Noncanonical RNA by Two-Dimensional Analysis of Mass Chromatograms. J Am Chem Soc. 2015 Nov 18; 137(45):14430-8.
PMID:
26495937
.
Citations:
7
Fields:
Che
Chemistry
Translation:
Cells
Larsen AT, Fahrenbach AC, Sheng J,
Pian J
,
Szostak JW
. Thermodynamic insights into 2-thiouridine-enhanced RNA hybridization. Nucleic Acids Res. 2015 Sep 18; 43(16):7675-87.
PMID:
26240387
.
Citations:
13
Fields:
Bio
Biochemistry
Translation:
Cells
Kamat NP, Tobé S, Hill IT,
Szostak JW
. Electrostatic Localization of RNA to Protocell Membranes by Cationic Hydrophobic Peptides. Angew Chem Int Ed Engl. 2015 Sep 28; 54(40):11735-9.
PMID:
26223820
.
Citations:
15
Fields:
Che
Chemistry
Translation:
Cells
Adamala K, Engelhart AE, Kamat NP, Jin L,
Szostak JW
. Construction of a liposome dialyzer for the preparation of high-value, small-volume liposome formulations. Nat Protoc. 2015 Jun; 10(6):927-38.
PMID:
26020615
.
Citations:
3
Fields:
Cli
Clinical Laboratory Techniques
Sci
Science
Translation:
Cells
Izgu EC, Fahrenbach AC, Zhang N, Li L, Zhang W, Larsen AT, Blain JC,
Szostak JW
. Uncovering the thermodynamics of monomer binding for RNA replication. J Am Chem Soc. 2015 May 20; 137(19):6373-82.
PMID:
25901790
.
Citations:
9
Fields:
Che
Chemistry
Translation:
Cells
Heuberger BD, Pal A, Del Frate F, Topkar VV,
Szostak JW
. Replacing uridine with 2-thiouridine enhances the rate and fidelity of nonenzymatic RNA primer extension. J Am Chem Soc. 2015 Feb 25; 137(7):2769-75.
PMID:
25654265
.
Citations:
19
Fields:
Che
Chemistry
Translation:
Cells
Adamala K, Engelhart AE,
Szostak JW
. Generation of functional RNAs from inactive oligonucleotide complexes by non-enzymatic primer extension. J Am Chem Soc. 2015 Jan 14; 137(1):483-9.
PMID:
25521912
.
Citations:
6
Fields:
Che
Chemistry
Translation:
Cells
Hentrich C,
Szostak JW
. Controlled growth of filamentous fatty acid vesicles under flow. Langmuir. 2014 Dec 16; 30(49):14916-25.
PMID:
25402759
.
Citations:
5
Fields:
Che
Chemistry
Budin I, Prwyes N, Zhang N,
Szostak JW
. Chain-length heterogeneity allows for the assembly of fatty acid vesicles in dilute solutions. Biophys J. 2014 Oct 07; 107(7):1582-90.
PMID:
25296310
.
Citations:
18
Fields:
Bio
Biophysics
Sheng J, Larsen A, Heuberger BD, Blain JC,
Szostak JW
. Crystal structure studies of RNA duplexes containing s(2)U:A and s(2)U:U base pairs. J Am Chem Soc. 2014 Oct 01; 136(39):13916-24.
PMID:
25188906
.
Citations:
14
Fields:
Che
Chemistry
Translation:
Cells
Blain JC,
Szostak JW
. Progress toward synthetic cells. Annu Rev Biochem. 2014; 83:615-40.
PMID:
24606140
.
Citations:
57
Fields:
Bio
Biochemistry
Translation:
Cells
Jia TZ, Hentrich C,
Szostak JW
. Rapid RNA exchange in aqueous two-phase system and coacervate droplets. Orig Life Evol Biosph. 2014 Feb; 44(1):1-12.
PMID:
24577897
.
Citations:
22
Fields:
Bio
Biology
Mol
Molecular Biology
Translation:
Cells
Sheng J, Li L, Engelhart AE, Gan J, Wang J,
Szostak JW
. Structural insights into the effects of 2'-5' linkages on the RNA duplex. Proc Natl Acad Sci U S A. 2014 Feb 25; 111(8):3050-5.
PMID:
24516151
.
Citations:
19
Fields:
Sci
Science
Translation:
Cells
Li L,
Szostak JW
. The free energy landscape of pseudorotation in 3'-5' and 2'-5' linked nucleic acids. J Am Chem Soc. 2014 Feb 19; 136(7):2858-65.
PMID:
24499340
.
Citations:
9
Fields:
Che
Chemistry
Translation:
Cells
Blain JC, Ricardo A,
Szostak JW
. Synthesis and nonenzymatic template-directed polymerization of 2'-amino-2'-deoxythreose nucleotides. J Am Chem Soc. 2014 Feb 05; 136(5):2033-9.
PMID:
24409991
.
Citations:
7
Fields:
Che
Chemistry
Translation:
Cells
Adamala K,
Szostak JW
. Nonenzymatic template-directed RNA synthesis inside model protocells. Science. 2013 Nov 29; 342(6162):1098-100.
PMID:
24288333
.
Citations:
88
Fields:
Sci
Science
Translation:
Cells
Josephson K, Ricardo A,
Szostak JW
. mRNA display: from basic principles to macrocycle drug discovery. Drug Discov Today. 2014 Apr; 19(4):388-99.
PMID:
24157402
.
Citations:
33
Fields:
Dru
Drug Therapy
Pha
Pharmacology
Translation:
Cells
Zhang S, Blain JC, Zielinska D, Gryaznov SM,
Szostak JW
. Fast and accurate nonenzymatic copying of an RNA-like synthetic genetic polymer. Proc Natl Acad Sci U S A. 2013 Oct 29; 110(44):17732-7.
PMID:
24101473
.
Citations:
24
Fields:
Sci
Science
Adamala K,
Szostak JW
. Competition between model protocells driven by an encapsulated catalyst. Nat Chem. 2013 Jun; 5(6):495-501.
PMID:
23695631
.
Citations:
61
Fields:
Che
Chemistry
Translation:
Cells
Engelhart AE, Powner MW,
Szostak JW
. Functional RNAs exhibit tolerance for non-heritable 2'-5' versus 3'-5' backbone heterogeneity. Nat Chem. 2013 May; 5(5):390-4.
PMID:
23609089
.
Citations:
34
Fields:
Che
Chemistry
Translation:
Cells
Zhang S, Zhang N, Blain JC,
Szostak JW
. Synthesis of N3'-P5'-linked phosphoramidate DNA by nonenzymatic template-directed primer extension. J Am Chem Soc. 2013 Jan 16; 135(2):924-32.
PMID:
23252395
.
Citations:
13
Fields:
Che
Chemistry
Translation:
Cells
Zhu TF, Budin I,
Szostak JW
. Preparation of fatty acid or phospholipid vesicles by thin-film rehydration. Methods Enzymol. 2013; 533:267-74.
PMID:
24182932
.
Citations:
Fields:
Bio
Biochemistry
Zhu TF, Budin I,
Szostak JW
. Preparation of fatty acid micelles. Methods Enzymol. 2013; 533:283-8.
PMID:
24182934
.
Citations:
1
Fields:
Bio
Biochemistry
Zhu TF, Budin I,
Szostak JW
. Vesicle extrusion through polycarbonate track-etched membranes using a hand-held mini-extruder. Methods Enzymol. 2013; 533:275-82.
PMID:
24182933
.
Citations:
5
Fields:
Bio
Biochemistry
Budin I, Debnath A,
Szostak JW
. Concentration-driven growth of model protocell membranes. J Am Chem Soc. 2012 Dec 26; 134(51):20812-9.
PMID:
23198690
.
Citations:
30
Fields:
Che
Chemistry
Translation:
Cells
Powner MW, Zheng SL,
Szostak JW
. Multicomponent assembly of proposed DNA precursors in water. J Am Chem Soc. 2012 Aug 22; 134(33):13889-95.
PMID:
22839703
.
Citations:
8
Fields:
Che
Chemistry
Zhu TF, Adamala K, Zhang N,
Szostak JW
. Photochemically driven redox chemistry induces protocell membrane pearling and division. Proc Natl Acad Sci U S A. 2012 Jun 19; 109(25):9828-32.
PMID:
22665773
.
Citations:
21
Fields:
Sci
Science
Translation:
Cells
Hofmann FT,
Szostak JW
, Seebeck FP. In vitro selection of functional lantipeptides. J Am Chem Soc. 2012 May 16; 134(19):8038-41.
PMID:
22545861
.
Citations:
13
Fields:
Che
Chemistry
Translation:
Cells
Schlippe YV, Hartman MC, Josephson K,
Szostak JW
. In vitro selection of highly modified cyclic peptides that act as tight binding inhibitors. J Am Chem Soc. 2012 Jun 27; 134(25):10469-77.
PMID:
22428867
.
Citations:
36
Fields:
Che
Chemistry
Translation:
Cells
Zhang N, Zhang S,
Szostak JW
. Activated ribonucleotides undergo a sugar pucker switch upon binding to a single-stranded RNA template. J Am Chem Soc. 2012 Feb 29; 134(8):3691-4.
PMID:
22296305
.
Citations:
14
Fields:
Che
Chemistry
Translation:
Cells
Szostak JW
. Attempts to define life do not help to understand the origin of life. J Biomol Struct Dyn. 2012; 29(4):599-600.
PMID:
22208251
.
Citations:
10
Fields:
Bio
Biochemistry
Mol
Molecular Biology
Szostak JW
. An optimal degree of physical and chemical heterogeneity for the origin of life? Philos Trans R Soc Lond B Biol Sci. 2011 Oct 27; 366(1580):2894-901.
PMID:
21930580
.
Citations:
31
Fields:
Bio
Biology
Translation:
Cells
Trevino SG, Zhang N, Elenko MP, Lupták A,
Szostak JW
. Evolution of functional nucleic acids in the presence of nonheritable backbone heterogeneity. Proc Natl Acad Sci U S A. 2011 Aug 16; 108(33):13492-7.
PMID:
21825162
.
Citations:
19
Fields:
Sci
Science
Translation:
Cells
Seebeck FP, Ricardo A,
Szostak JW
. Artificial lantipeptides from in vitro translations. Chem Commun (Camb). 2011 Jun 07; 47(21):6141-3.
PMID:
21528125
.
Citations:
10
Fields:
Che
Chemistry
Translation:
Cells
Budin I,
Szostak JW
. Physical effects underlying the transition from primitive to modern cell membranes. Proc Natl Acad Sci U S A. 2011 Mar 29; 108(13):5249-54.
PMID:
21402937
.
Citations:
63
Fields:
Sci
Science
Translation:
Cells
Subtelny AO
, Hartman MC,
Szostak JW
. Optimal codon choice can improve the efficiency and fidelity of N-methyl amino acid incorporation into peptides by in-vitro translation. Angew Chem Int Ed Engl. 2011 Mar 28; 50(14):3164-7.
PMID:
21381166
.
Citations:
3
Fields:
Che
Chemistry
Translation:
Cells
Powner MW, Sutherland JD,
Szostak JW
. Chemoselective multicomponent one-pot assembly of purine precursors in water. J Am Chem Soc. 2010 Nov 24; 132(46):16677-88.
PMID:
21043502
.
Citations:
36
Fields:
Che
Chemistry
Translation:
Cells
Szostak JW
. DNA ends: just the beginning (Nobel lecture). Angew Chem Int Ed Engl. 2010 Oct 04; 49(41):7386-404.
PMID:
20818632
.
Citations:
4
Fields:
Che
Chemistry
Translation:
Humans
Animals
Cells
Elenko MP,
Szostak JW
, van Oijen AM. Single-molecule binding experiments on long time scales. Rev Sci Instrum. 2010 Aug; 81(8):083705.
PMID:
20815611
.
Citations:
5
Fields:
Bio
Biomedical Engineering
Bio
Biophysics
Phy
Physics
Translation:
Cells
Schrum JP, Zhu TF,
Szostak JW
. The origins of cellular life. Cold Spring Harb Perspect Biol. 2010 Sep; 2(9):a002212.
PMID:
20484387
.
Citations:
39
Fields:
Bio
Biology
Translation:
Cells
Rajamani S,
Ichida JK
, Antal T, Treco DA, Leu K, Nowak MA,
Szostak JW
, Chen IA. Effect of stalling after mismatches on the error catastrophe in nonenzymatic nucleic acid replication. J Am Chem Soc. 2010 Apr 28; 132(16):5880-5.
PMID:
20359213
.
Citations:
40
Fields:
Che
Chemistry
Translation:
Cells
Budin I,
Szostak JW
. Expanding roles for diverse physical phenomena during the origin of life. Annu Rev Biophys. 2010; 39:245-63.
PMID:
20192779
.
Citations:
33
Fields:
Bio
Biophysics
Translation:
Cells
Bruckner RJ, Mansy SS, Ricardo A, Mahadevan L,
Szostak JW
. Flip-flop-induced relaxation of bending energy: implications for membrane remodeling. Biophys J. 2009 Dec 16; 97(12):3113-22.
PMID:
20006948
.
Citations:
28
Fields:
Bio
Biophysics
Translation:
Animals
Cells
Schrum JP, Ricardo A, Krishnamurthy M, Blain JC,
Szostak JW
. Efficient and rapid template-directed nucleic acid copying using 2'-amino-2',3'-dideoxyribonucleoside-5'-phosphorimidazolide monomers. J Am Chem Soc. 2009 Oct 14; 131(40):14560-70.
PMID:
19757789
.
Citations:
37
Fields:
Che
Chemistry
Mansy SS,
Szostak JW
. Reconstructing the emergence of cellular life through the synthesis of model protocells. Cold Spring Harb Symp Quant Biol. 2009; 74:47-54.
PMID:
19734203
.
Citations: