Harvard Catalyst Profiles

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Bradley John Molyneaux, M.D., M.D.,Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Bhuiyan MIH, Fischer S, Patel SM, Oft H, Zhang T, Foley LM, Zhang J, Hitchens TK, Molyneaux BJ, Deng X, Sun D. Efficacy of novel SPAK inhibitor ZT-1a derivatives (1c, 1d, 1g & 1h) on improving post-stroke neurological outcome and brain lesion in mice. Neurochem Int. 2023 Jan; 162:105441. PMID: 36375633; PMCID: PMC9839627.
    Citations:    Fields:    Translation:Animals
  2. Irvine HJ, Acharjee A, Wolcott Z, Ament Z, Hinson HE, Molyneaux BJ, Simard JM, Sheth KN, Kimberly WT. Hypoxanthine is a pharmacodynamic marker of ischemic brain edema modified by glibenclamide. Cell Rep Med. 2022 06 21; 3(6):100654. PMID: 35700741; PMCID: PMC9244997.
    Citations:    Fields:    Translation:Humans
  3. Bhuiyan MIH, Young CB, Jahan I, Hasan MN, Fischer S, Meor Azlan NF, Liu M, Chattopadhyay A, Huang H, Kahle KT, Zhang J, Poloyac SM, Molyneaux BJ, Straub AC, Deng X, Gomez D, Sun D. NF-?B Signaling-Mediated Activation of WNK-SPAK-NKCC1 Cascade in Worsened Stroke Outcomes of Ang II-Hypertensive Mice. Stroke. 2022 05; 53(5):1720-1734. PMID: 35272484; PMCID: PMC9038703.
    Citations:    Fields:    Translation:HumansAnimals
  4. Sobhani F, Desai S, Madill E, Starr M, Rocha M, Molyneaux B, Jovin T, Wechsler L, Jadhav A. Remote Longitudinal Inpatient Acute Stroke Care Via Telestroke. J Stroke Cerebrovasc Dis. 2021 Jun; 30(6):105749. PMID: 33784522.
    Citations:    Fields:    Translation:Humans
  5. Darby JM, Shutter LA, Elmer J, Hirzallah M, Khandker N, Molyneaux BJ, Kaynar AM, Nigra KR, Wechsler LR. Reliability of the Telemedicine Examination in the Neurologic Diagnosis of Death. Neurol Clin Pract. 2021 Feb; 11(1):13-17. PMID: 33968467; PMCID: PMC8101299.
    Citations: 1     
  6. Yeh CY, Schulien AJ, Molyneaux BJ, Aizenman E. Lessons from Recent Advances in Ischemic Stroke Management and Targeting Kv2.1 for Neuroprotection. Int J Mol Sci. 2020 Aug 25; 21(17). PMID: 32854248.
    Citations: 4     Fields:    Translation:HumansAnimals
  7. Desai SM, Tonetti DA, Morrison AA, Molyneaux BJ, Starr M, Rocha M, Gross BA, Jankowitz B, Jovin TG, Jadhav AP. Delayed functional independence after thrombectomy: temporal characteristics and predictors. J Neurointerv Surg. 2020 Sep; 12(9):837-841. PMID: 32487769.
    Citations:    Fields:    Translation:Humans
  8. Hinson HE, Sun E, Molyneaux BJ, von Kummer R, Demchuk A, Romero J, Taylor Kimberly W, Sheth KN. Osmotherapy for malignant cerebral edema in a phase 2 prospective, double blind, randomized, placebo-controlled study of IV glibenclamide. J Stroke Cerebrovasc Dis. 2020 Jul; 29(7):104916. PMID: 32414580.
    Citations: 2     Fields:    Translation:HumansCTClinical Trials
  9. Tonetti DA, Desai SM, Hudson J, Gross BA, Jha RM, Molyneaux BJ, Jankowitz BT, Jovin TG, Jadhav AP. Large Infarct Volume Post Thrombectomy: Characteristics, Outcomes, and Predictors. World Neurosurg. 2020 07; 139:e748-e753. PMID: 32353539.
    Citations: 1     Fields:    Translation:Humans
  10. Desai SM, Tonetti DA, Molyneaux BJ, Atchaneeyasakul K, Rocha M, Jovin TG, Jadhav AP. Interaction between time, ASPECTS, and clinical mismatch. J Neurointerv Surg. 2020 Sep; 12(9):911-914. PMID: 32245842.
    Citations: 1     Fields:    Translation:Humans
  11. Zhang J, Bhuiyan MIH, Zhang T, Karimy JK, Wu Z, Fiesler VM, Zhang J, Huang H, Hasan MN, Skrzypiec AE, Mucha M, Duran D, Huang W, Pawlak R, Foley LM, Hitchens TK, Minnigh MB, Poloyac SM, Alper SL, Molyneaux BJ, Trevelyan AJ, Kahle KT, Sun D, Deng X. Modulation of brain cation-Cl- cotransport via the SPAK kinase inhibitor ZT-1a. Nat Commun. 2020 01 07; 11(1):78. PMID: 31911626; PMCID: PMC6946680.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  12. Elmer J, Molyneaux BJ, Shutterly K, Stuart SA, Callaway CW, Darby JM, Weisgerber AR. Organ donation after resuscitation from cardiac arrest. Resuscitation. 2019 12; 145:63-69. PMID: 31654724.
    Citations: 2     Fields:    Translation:Humans
  13. Vorasayan P, Bevers MB, Beslow LA, Sze G, Molyneaux BJ, Hinson HE, Simard JM, von Kummer R, Sheth KN, Kimberly WT. Intravenous Glibenclamide Reduces Lesional Water Uptake in Large Hemispheric Infarction. Stroke. 2019 11; 50(11):3021-3027. PMID: 31537189.
    Citations: 22     Fields:    Translation:Humans
  14. Albers GW, Wald MJ, Mlynash M, Endres J, Bammer R, Straka M, Maier A, Hinson HE, Sheth KN, Taylor Kimberly W, Molyneaux BJ. Automated Calculation of Alberta Stroke Program Early CT Score: Validation in Patients With Large Hemispheric Infarct. Stroke. 2019 11; 50(11):3277-3279. PMID: 31500555.
    Citations: 8     Fields:    Translation:Humans
  15. Desai SM, Starr M, Molyneaux BJ, Rocha M, Jovin TG, Jadhav AP. Acute Ischemic Stroke with Vessel Occlusion-Prevalence and Thrombectomy Eligibility at a Comprehensive Stroke Center. J Stroke Cerebrovasc Dis. 2019 Nov; 28(11):104315. PMID: 31409537.
    Citations: 3     Fields:    Translation:Humans
  16. Huang H, Bhuiyan MIH, Jiang T, Song S, Shankar S, Taheri T, Li E, Schreppel P, Hintersteininger M, Yang SS, Lin SH, Molyneaux BJ, Zhang Z, Erker T, Sun D. A Novel Na+-K+-Cl- Cotransporter 1 Inhibitor STS66* Reduces Brain Damage in Mice After Ischemic Stroke. Stroke. 2019 04; 50(4):1021-1025. PMID: 30862257.
    Citations: 14     Fields:    Translation:Animals
  17. Faro J, Coppler PJ, Dezfulian C, Baldwin M, Molyneaux BJ, Urban A, Rittenberger JC, Callaway CW, Elmer J. Differential association of subtypes of epileptiform activity with outcome after cardiac arrest. Resuscitation. 2019 03; 136:138-145. PMID: 30586605; PMCID: PMC6397672.
    Citations: 4     Fields:    Translation:Humans
  18. Kimberly WT, Bevers MB, von Kummer R, Demchuk AM, Romero JM, Elm JJ, Hinson HE, Molyneaux BJ, Simard JM, Sheth KN. Effect of IV glyburide on adjudicated edema endpoints in the GAMES-RP Trial. Neurology. 2018 12 04; 91(23):e2163-e2169. PMID: 30446594.
    Citations: 19     Fields:    Translation:HumansCTClinical Trials
  19. Jadhav AP, Molyneaux BJ, Hill MD, Jovin TG. Care of the Post-Thrombectomy Patient. Stroke. 2018 11; 49(11):2801-2807. PMID: 30355218.
    Citations: 14     Fields:    Translation:Humans
  20. Desai SM, Rocha M, Starr M, Molyneaux BJ, Kenmuir CL, Gross BA, Jankowitz BT, Jovin TG, Jadhav AP. Laterality is an Independent Predictor of Endovascular Thrombectomy in Patients With Low National Institute of Health Stroke Scale. J Stroke Cerebrovasc Dis. 2018 Nov; 27(11):3172-3176. PMID: 30078759.
    Citations: 1     Fields:    Translation:Humans
  21. Jha RM, Molyneaux BJ, Jackson TC, Wallisch JS, Park SY, Poloyac S, Vagni VA, Janesko-Feldman KL, Hoshitsuki K, Minnigh MB, Kochanek PM. Glibenclamide Produces Region-Dependent Effects on Cerebral Edema in a Combined Injury Model of Traumatic Brain Injury and Hemorrhagic Shock in Mice. J Neurotrauma. 2018 09 01; 35(17):2125-2135. PMID: 29648981; PMCID: PMC6098411.
    Citations: 20     Fields:    Translation:Animals
  22. Sheth KN, Petersen NH, Cheung K, Elm JJ, Hinson HE, Molyneaux BJ, Beslow LA, Sze GK, Simard JM, Kimberly WT. Long-Term Outcomes in Patients Aged =70 Years With Intravenous Glyburide From the Phase II GAMES-RP Study of Large Hemispheric Infarction: An Exploratory Analysis. Stroke. 2018 06; 49(6):1457-1463. PMID: 29789393.
    Citations: 23     Fields:    Translation:HumansCTClinical Trials
  23. Desai SM, Rocha M, Molyneaux BJ, Starr M, Kenmuir CL, Gross BA, Jankowitz BT, Jovin TG, Jadhav AP. Thrombectomy 6-24 hours after stroke in trial ineligible patients. J Neurointerv Surg. 2018 Nov; 10(11):1033-1037. PMID: 29773716.
    Citations: 15     Fields:    Translation:HumansCTClinical Trials
  24. Jadhav AP, Desai SM, Kenmuir CL, Rocha M, Starr MT, Molyneaux BJ, Gross BA, Jankowitz BT, Jovin TG. Eligibility for Endovascular Trial Enrollment in the 6- to 24-Hour Time Window: Analysis of a Single Comprehensive Stroke Center. Stroke. 2018 04; 49(4):1015-1017. PMID: 29581344.
    Citations: 29     Fields:    Translation:Humans
  25. Jadhav AP, Kenmuir CL, Aghaebrahim A, Limaye K, Wechsler LR, Hammer MD, Starr MT, Molyneaux BJ, Rocha M, Guyette FX, Martin-Gill C, Ducruet AF, Gross BA, Jankowitz BT, Jovin TG. Interfacility Transfer Directly to the Neuroangiography Suite in Acute Ischemic Stroke Patients Undergoing Thrombectomy. Stroke. 2017 07; 48(7):1884-1889. PMID: 28536177.
    Citations: 13     Fields:    Translation:Humans
  26. Jha RM, Puccio AM, Chou SH, Chang CH, Wallisch JS, Molyneaux BJ, Zusman BE, Shutter LA, Poloyac SM, Janesko-Feldman KL, Okonkwo DO, Kochanek PM. Sulfonylurea Receptor-1: A Novel Biomarker for Cerebral Edema in Severe Traumatic Brain Injury. Crit Care Med. 2017 03; 45(3):e255-e264. PMID: 27845954; PMCID: PMC5550829.
    Citations: 24     Fields:    Translation:Humans
  27. Rivosecchi RM, Durkin J, Okonkwo DO, Molyneaux BJ. Safety and Efficacy of Warfarin Reversal with Four-Factor Prothrombin Complex Concentrate for Subtherapeutic INR in Intracerebral Hemorrhage. Neurocrit Care. 2016 12; 25(3):359-364. PMID: 27076286.
    Citations: 6     Fields:    Translation:Humans
  28. Streib CD, Hartman LM, Molyneaux BJ. Early decompressive craniectomy for malignant cerebral infarction: Meta-analysis and clinical decision algorithm. Neurol Clin Pract. 2016 Oct; 6(5):433-443. PMID: 27847685; PMCID: PMC5100704.
    Citations: 3     
  29. Sheth KN, Elm JJ, Molyneaux BJ, Hinson H, Beslow LA, Sze GK, Ostwaldt AC, Del Zoppo GJ, Simard JM, Jacobson S, Kimberly WT. Safety and efficacy of intravenous glyburide on brain swelling after large hemispheric infarction (GAMES-RP): a randomised, double-blind, placebo-controlled phase 2 trial. Lancet Neurol. 2016 Oct; 15(11):1160-9. PMID: 27567243.
    Citations: 85     Fields:    Translation:HumansCTClinical Trials
  30. Elmer J, Rittenberger JC, Faro J, Molyneaux BJ, Popescu A, Callaway CW, Baldwin M. Clinically distinct electroencephalographic phenotypes of early myoclonus after cardiac arrest. Ann Neurol. 2016 08; 80(2):175-84. PMID: 27351833; PMCID: PMC4982787.
    Citations: 49     Fields:    Translation:Humans
  31. Kishi N, MacDonald JL, Ye J, Molyneaux BJ, Azim E, Macklis JD. Reduction of aberrant NF-?B signalling ameliorates Rett syndrome phenotypes in Mecp2-null mice. Nat Commun. 2016 Jan 29; 7:10520. PMID: 26821816.
    Citations: 26     Fields:    Translation:AnimalsCells
  32. Callaway CW, Elmer J, Guyette FX, Molyneaux BJ, Anderson KB, Empey PE, Gerstel SJ, Holquist K, Repine MJ, Rittenberger JC. Dexmedetomidine Reduces Shivering during Mild Hypothermia in Waking Subjects. PLoS One. 2015; 10(8):e0129709. PMID: 26237219.
    Citations: 13     Fields:    Translation:Humans
  33. Molyneaux BJ, Goff LA, Brettler AC, Chen HH, Hrvatin S, Rinn JL, Arlotta P. DeCoN: genome-wide analysis of in vivo transcriptional dynamics during pyramidal neuron fate selection in neocortex. Neuron. 2015 Jan 21; 85(2):275-288. PMID: 25556833; PMCID: PMC4430475.
    Citations: 125     Fields:    Translation:AnimalsCells
  34. Aghaebrahim A, Jadhav AP, Saeed Y, Totoraitis R, Jankowitz BT, Jovin TG, Molyneaux BJ. Reversible cerebral vasoconstriction syndrome following carotid stenting. Neurology. 2014 Aug 05; 83(6):570-1. PMID: 25092927.
    Citations: 4     Fields:    Translation:Humans
  35. Lodato S, Molyneaux BJ, Zuccaro E, Goff LA, Chen HH, Yuan W, Meleski A, Takahashi E, Mahony S, Rinn JL, Gifford DK, Arlotta P. Gene co-regulation by Fezf2 selects neurotransmitter identity and connectivity of corticospinal neurons. Nat Neurosci. 2014 Aug; 17(8):1046-54. PMID: 24997765.
    Citations: 53     Fields:    Translation:AnimalsCells
  36. Hernandez-Lain A, Hedley-Whyte ET, Hariri LP, Molyneaux B, Nagle KJ, Cole AJ, Kilbride R. Pathology of bilateral pulvinar degeneration following long duration status epilepticus. Seizure. 2013 Dec; 22(10):901-4. PMID: 23962521.
    Citations: 3     Fields:    Translation:HumansCells
  37. Molyneaux BJ, Arlotta P, Fame RM, MacDonald JL, MacQuarrie KL, Macklis JD. Novel subtype-specific genes identify distinct subpopulations of callosal projection neurons. J Neurosci. 2009 Sep 30; 29(39):12343-54. PMID: 19793993.
    Citations: 94     Fields:    Translation:AnimalsCells
  38. Joshi PS, Molyneaux BJ, Feng L, Xie X, Macklis JD, Gan L. Bhlhb5 regulates the postmitotic acquisition of area identities in layers II-V of the developing neocortex. Neuron. 2008 Oct 23; 60(2):258-72. PMID: 18957218.
    Citations: 90     Fields:    Translation:AnimalsCells
  39. Lai T, Jabaudon D, Molyneaux BJ, Azim E, Arlotta P, Menezes JR, Macklis JD. SOX5 controls the sequential generation of distinct corticofugal neuron subtypes. Neuron. 2008 Jan 24; 57(2):232-47. PMID: 18215621.
    Citations: 152     Fields:    Translation:AnimalsCells
  40. Arlotta P, Molyneaux BJ, Jabaudon D, Yoshida Y, Macklis JD. Ctip2 controls the differentiation of medium spiny neurons and the establishment of the cellular architecture of the striatum. J Neurosci. 2008 Jan 16; 28(3):622-32. PMID: 18199763; PMCID: PMC6670353.
    Citations: 144     Fields:    Translation:HumansAnimalsCells
  41. Molyneaux BJ, Arlotta P, Menezes JR, Macklis JD. Neuronal subtype specification in the cerebral cortex. Nat Rev Neurosci. 2007 Jun; 8(6):427-37. PMID: 17514196.
    Citations: 733     Fields:    Translation:HumansAnimalsCells
  42. Molyneaux BJ, Arlotta P, Macklis JD. Molecular development of corticospinal motor neuron circuitry. Novartis Found Symp. 2007; 288:3-15; discussion 15-20, 96-8. PMID: 18494249.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  43. Molyneaux BJ, Arlotta P, Hirata T, Hibi M, Macklis JD. Fezl is required for the birth and specification of corticospinal motor neurons. Neuron. 2005 Sep 15; 47(6):817-31. PMID: 16157277.
    Citations: 228     Fields:    Translation:AnimalsCells
  44. Arlotta P, Molyneaux BJ, Chen J, Inoue J, Kominami R, Macklis JD. Neuronal subtype-specific genes that control corticospinal motor neuron development in vivo. Neuron. 2005 Jan 20; 45(2):207-21. PMID: 15664173.
    Citations: 527     Fields:    Translation:AnimalsCells
  45. Molyneaux BJ, Hasselmo ME. GABA(B) presynaptic inhibition has an in vivo time constant sufficiently rapid to allow modulation at theta frequency. J Neurophysiol. 2002 Mar; 87(3):1196-205. PMID: 11877493.
    Citations: 14     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.