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Filip K. Swirski, Ph.D.

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Biography
McMaster University, Hamilton, CanadaB Arts Sci05/1998Biochemistry
McMaster University, Hamilton, CanadaPhD02/2004Immunology
Brigham and Women's Hospital, Boston, MA02/2007Vascular Biology
2014 - 2016
Howard M. Goodman Fellowship
2016 - 2016
Martin Prize for Fundamental Research
2016 - 2021
Patricia and Scott Eston MGH Research Scholar
2017 - 2017
Jeffrey Hoeg Award for Basic Science and Clinical Research
2016 - 2023
Outstanding Investigator Award
2017 - 2022
Established Investigator Award

Overview
Dr. Swirski is Professor of Radiology at Harvard Medical School, Massachusetts General Hospital Research Scholar, Faculty Member of Harvard Medical School's PhD Program in Immunology, and Member of Harvard Medical School's Division of Sleep Medicine. He has focused on fundamental innate immune and inflammatory mechanisms in cardiovascular disease, emphasizing the role of monocytes and macrophages. His current work aims to elucidate how lifestyle factors such as sleep, stress, and diet influence leukocyte-mediated physiology in cardiometabolic and neurodegenerative diseases.

Featured Content

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. McAlpine CS, Park J, Griciuc A, Kim E, Choi SH, Iwamoto Y, Kiss MG, Christie KA, Vinegoni C, Poller WC, Mindur JE, Chan CT, He S, Janssen H, Wong LP, Downey J, Singh S, Anzai A, Kahles F, Jorfi M, Feruglio PF, Sadreyev RI, Weissleder R, Kleinstiver BP, Nahrendorf M, Tanzi RE, Swirski FK. Astrocytic interleukin-3 programs microglia and limits Alzheimer's disease. Nature. 2021 Jul; 595(7869):701-706. PMID: 34262178.
    Citations:    Fields:    
  2. van Leent MMT, Beldman TJ, Toner YC, Lameijer MA, Rother N, Bekkering S, Teunissen AJP, Zhou X, van der Meel R, Malkus J, Nauta SA, Klein ED, Fay F, Sanchez-Gaytan BL, Pérez-Medina C, Kluza E, Ye YX, Wojtkiewicz G, Fisher EA, Swirski FK, Nahrendorf M, Zhang B, Li Y, Zhang B, Joosten LAB, Pasterkamp G, Boltjes A, Fayad ZA, Lutgens E, Netea MG, Riksen NP, Mulder WJM, Duivenvoorden R. Prosaposin mediates inflammation in atherosclerosis. Sci Transl Med. 2021 03 10; 13(584). PMID: 33692130.
    Citations: 2     Fields:    Translation:Animals
  3. Heyde A, Rohde D, McAlpine CS, Zhang S, Hoyer FF, Gerold JM, Cheek D, Iwamoto Y, Schloss MJ, Vandoorne K, Iborra-Egea O, Muñoz-Guijosa C, Bayes-Genis A, Reiter JG, Craig M, Swirski FK, Nahrendorf M, Nowak MA, Naxerova K. Increased stem cell proliferation in atherosclerosis accelerates clonal hematopoiesis. Cell. 2021 03 04; 184(5):1348-1361.e22. PMID: 33636128.
    Citations: 4     Fields:    
  4. Bénard A, Jacobsen A, Brunner M, Krautz C, Klösch B, Swierzy I, Naschberger E, Podolska MJ, Kouhestani D, David P, Birkholz T, Castellanos I, Trufa D, Sirbu H, Vetter M, Kremer AE, Hildner K, Hecker A, Edinger F, Tenbusch M, Mühl-Zürbes P, Steinkasserer A, Richter E, Streeck H, Berger MM, Brenner T, Weigand MA, Swirski FK, Schett G, Grützmann R, Weber GF. Interleukin-3 is a predictive marker for severity and outcome during SARS-CoV-2 infections. Nat Commun. 2021 02 18; 12(1):1112. PMID: 33602937.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  5. Härdtner C, Kornemann J, Krebs K, Ehlert CA, Jander A, Zou J, Starz C, Rauterberg S, Sharipova D, Dufner B, Hoppe N, Dederichs TS, Willecke F, Stachon P, Heidt T, Wolf D, von Zur Mühlen C, Madl J, Kohl P, Kaeser R, Boettler T, Pieterman EJ, Princen HMG, Ho-Tin-Noé B, Swirski FK, Robbins CS, Bode C, Zirlik A, Hilgendorf I. Inhibition of macrophage proliferation dominates plaque regression in response to cholesterol lowering. Basic Res Cardiol. 2020 12 09; 115(6):78. PMID: 33296022.
    Citations: 2     Fields:    
  6. Bogorodskaya M, Lyass A, Mahoney TF, Borowsky LH, Sen P, Swirski FK, Srinivasa S, Longenecker CT, Massaro JM, D'Agostino RB, Triant VA. Utilization of absolute monocyte counts to predict cardiovascular events in people living with HIV. HIV Med. 2021 Apr; 22(4):314-320. PMID: 33295150.
    Citations:    Fields:    
  7. Swirski FK. ESC William Harvey Lecture on Basic Science 2020. Eur Heart J. 2020 12 07; 41(46):4373-4374. PMID: 33349865.
    Citations:    Fields:    
  8. Panizzi P, Krohn-Grimberghe M, Keliher E, Ye YX, Grune J, Frodermann V, Sun Y, Muse CG, Bushey K, Iwamoto Y, van Leent MMT, Meerwaldt A, Toner YC, Munitz J, Maier A, Soultanidis G, Calcagno C, Pérez-Medina C, Carlucci G, Riddell KP, Barney S, Horne G, Anderson B, Maddur-Appajaiah A, Verhamme IM, Bock PE, Wojtkiewicz GR, Courties G, Swirski FK, Church WR, Walz PH, Tillson DM, Mulder WJM, Nahrendorf M. Multimodal imaging of bacterial-host interface in mice and piglets with Staphylococcus aureus endocarditis. Sci Transl Med. 2020 11 04; 12(568). PMID: 33148623.
    Citations:    Fields:    Translation:AnimalsCells
  9. Nahrendorf M, Hoyer FF, Meerwaldt AE, van Leent MMT, Senders ML, Calcagno C, Robson PM, Soultanidis G, Pérez-Medina C, Teunissen AJP, Toner YC, Ishikawa K, Fish K, Sakurai K, van Leeuwen EM, Klein ED, Sofias AM, Reiner T, Rohde D, Aguirre AD, Wojtkiewicz G, Schmidt S, Iwamoto Y, Izquierdo-Garcia D, Caravan P, Swirski FK, Weissleder R, Mulder WJM. Imaging Cardiovascular and Lung Macrophages With the Positron Emission Tomography Sensor 64Cu-Macrin in Mice, Rabbits, and Pigs. Circ Cardiovasc Imaging. 2020 10; 13(10):e010586. PMID: 33076700.
    Citations: 2     Fields:    Translation:AnimalsCells
  10. Chan CT, Fenn AM, Harder NK, Mindur JE, McAlpine CS, Patel J, Valet C, Rattik S, Iwamoto Y, He S, Anzai A, Kahles F, Poller WC, Janssen H, Wong LP, Fernandez-Hernando C, Koolbergen DR, van der Laan AM, Yvan-Charvet L, Sadreyev RI, Nahrendorf M, Westerterp M, Tall AR, Gustafsson JA, Swirski FK. Liver X receptors are required for thymic resilience and T cell output. J Exp Med. 2020 10 05; 217(10). PMID: 32716519.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  11. Krohn-Grimberghe M, Mitchell MJ, Schloss MJ, Khan OF, Courties G, Guimaraes PPG, Rohde D, Cremer S, Kowalski PS, Sun Y, Tan M, Webster J, Wang K, Iwamoto Y, Schmidt SP, Wojtkiewicz GR, Nayar R, Frodermann V, Hulsmans M, Chung A, Hoyer FF, Swirski FK, Langer R, Anderson DG, Nahrendorf M. Nanoparticle-encapsulated siRNAs for gene silencing in the haematopoietic stem-cell niche. Nat Biomed Eng. 2020 11; 4(11):1076-1089. PMID: 33020600.
    Citations: 5     Fields:    Translation:AnimalsCells
  12. Schloss MJ, Swirski FK, Nahrendorf M. Modifiable Cardiovascular Risk, Hematopoiesis, and Innate Immunity. Circ Res. 2020 04 24; 126(9):1242-1259. PMID: 32324501.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  13. Hoyer FF, Zhang X, Coppin E, Vasamsetti SB, Modugu G, Schloss MJ, Rohde D, McAlpine CS, Iwamoto Y, Libby P, Naxerova K, Swirski FK, Dutta P, Nahrendorf M. Bone Marrow Endothelial Cells Regulate Myelopoiesis in Diabetes Mellitus. Circulation. 2020 07 21; 142(3):244-258. PMID: 32316750.
    Citations: 7     Fields:    Translation:AnimalsCells
  14. Senders ML, Meerwaldt AE, van Leent MMT, Sanchez-Gaytan BL, van de Voort JC, Toner YC, Maier A, Klein ED, Sullivan NAT, Sofias AM, Groenen H, Faries C, Oosterwijk RS, van Leeuwen EM, Fay F, Chepurko E, Reiner T, Duivenvoorden R, Zangi L, Dijkhuizen RM, Hak S, Swirski FK, Nahrendorf M, Pérez-Medina C, Teunissen AJP, Fayad ZA, Calcagno C, Strijkers GJ, Mulder WJM. Probing myeloid cell dynamics in ischaemic heart disease by nanotracer hot-spot imaging. Nat Nanotechnol. 2020 05; 15(5):398-405. PMID: 32313216.
    Citations: 3     Fields:    Translation:AnimalsCells
  15. Poller WC, Nahrendorf M, Swirski FK. Hematopoiesis and Cardiovascular Disease. Circ Res. 2020 04 10; 126(8):1061-1085. PMID: 32271679.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  16. Figueiredo JL, Santa-Cruz F, Lima-Filho JL, Hilgendorf I, Aikawa M, Pittet MJ, Nahrendorf M, Weissleder R, Swirski FK, Robbins CS. A durable murine model of spleen transplantation with arterial and venous anastomoses. Sci Rep. 2020 03 04; 10(1):3979. PMID: 32132617.
    Citations:    Fields:    Translation:Animals
  17. Cremer S, Schloss MJ, Vinegoni C, Foy BH, Zhang S, Rohde D, Hulsmans M, Fumene Feruglio P, Schmidt S, Wojtkiewicz G, Higgins JM, Weissleder R, Swirski FK, Nahrendorf M. Diminished Reactive Hematopoiesis and Cardiac Inflammation in a Mouse Model of Recurrent Myocardial Infarction. J Am Coll Cardiol. 2020 03 03; 75(8):901-915. PMID: 32130926.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  18. Swirski FK. Platelets have a dangerous hold over immune cells in cardiovascular disease. Nature. 2020 01; 577(7790):323-324. PMID: 31937950.
    Citations: 1     Fields:    Translation:HumansCells
  19. Libby P, Swirski FK, Nahrendorf M. The Myocardium: More Than Myocytes. J Am Coll Cardiol. 2019 12 24; 74(25):3136-3138. PMID: 31856970.
    Citations:    Fields:    Translation:HumansCells
  20. Hoyer FF, Naxerova K, Schloss MJ, Hulsmans M, Nair AV, Dutta P, Calcagno DM, Herisson F, Anzai A, Sun Y, Wojtkiewicz G, Rohde D, Frodermann V, Vandoorne K, Courties G, Iwamoto Y, Garris CS, Williams DL, Breton S, Brown D, Whalen M, Libby P, Pittet MJ, King KR, Weissleder R, Swirski FK, Nahrendorf M. Tissue-Specific Macrophage Responses to Remote Injury Impact the Outcome of Subsequent Local Immune Challenge. Immunity. 2019 11 19; 51(5):899-914.e7. PMID: 31732166.
    Citations: 19     Fields:    Translation:AnimalsCells
  21. Frodermann V, Rohde D, Courties G, Severe N, Schloss MJ, Amatullah H, McAlpine CS, Cremer S, Hoyer FF, Ji F, van Koeverden ID, Herisson F, Honold L, Masson GS, Zhang S, Grune J, Iwamoto Y, Schmidt SP, Wojtkiewicz GR, Lee IH, Gustafsson K, Pasterkamp G, de Jager SCA, Sadreyev RI, MacFadyen J, Libby P, Ridker P, Scadden DT, Naxerova K, Jeffrey KL, Swirski FK, Nahrendorf M. Exercise reduces inflammatory cell production and cardiovascular inflammation via instruction of hematopoietic progenitor cells. Nat Med. 2019 11; 25(11):1761-1771. PMID: 31700184.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  22. Binderup T, Duivenvoorden R, Fay F, van Leent MMT, Malkus J, Baxter S, Ishino S, Zhao Y, Sanchez-Gaytan B, Teunissen AJP, Frederico YCA, Tang J, Carlucci G, Lyashchenko S, Calcagno C, Karakatsanis N, Soultanidis G, Senders ML, Robson PM, Mani V, Ramachandran S, Lobatto ME, Hutten BA, Granada JF, Reiner T, Swirski FK, Nahrendorf M, Kjaer A, Fisher EA, Fayad ZA, Pérez-Medina C, Mulder WJM. Imaging-assisted nanoimmunotherapy for atherosclerosis in multiple species. Sci Transl Med. 2019 08 21; 11(506). PMID: 31434756.
    Citations: 11     Fields:    Translation:Animals
  23. Vromman A, Ruvkun V, Shvartz E, Wojtkiewicz G, Santos Masson G, Tesmenitsky Y, Folco E, Gram H, Nahrendorf M, Swirski FK, Sukhova GK, Libby P. Stage-dependent differential effects of interleukin-1 isoforms on experimental atherosclerosis. Eur Heart J. 2019 08 07; 40(30):2482-2491. PMID: 30698710.
    Citations: 19     Fields:    Translation:AnimalsCells
  24. Wang Y, Sano S, Oshima K, Sano M, Watanabe Y, Katanasaka Y, Yura Y, Jung C, Anzai A, Swirski FK, Gokce N, Walsh K. Wnt5a-Mediated Neutrophil Recruitment Has an Obligatory Role in Pressure Overload-Induced Cardiac Dysfunction. Circulation. 2019 08 06; 140(6):487-499. PMID: 31170826.
    Citations: 12     Fields:    Translation:AnimalsCells
  25. Ramírez CM, Zhang X, Bandyopadhyay C, Rotllan N, Sugiyama MG, Aryal B, Liu X, He S, Kraehling JR, Ulrich V, Lin CS, Velazquez H, Lasunción MA, Li G, Suárez Y, Tellides G, Swirski FK, Lee WL, Schwartz MA, Sessa WC, Fernández-Hernando C. Caveolin-1 Regulates Atherogenesis by Attenuating Low-Density Lipoprotein Transcytosis and Vascular Inflammation Independently of Endothelial Nitric Oxide Synthase Activation. Circulation. 2019 07 16; 140(3):225-239. PMID: 31154825.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  26. Shikatani EA, Besla R, Ensan S, Upadhye A, Khyzha N, Li A, Emoto T, Chiu F, Degousee N, Moreau JM, Perry HM, Thayaparan D, Cheng HS, Pacheco S, Smyth D, Noyan H, Zavitz CCJ, Bauer CMT, Hilgendorf I, Libby P, Swirski FK, Gommerman JL, Fish JE, Stampfli MR, Cybulsky MI, Rubin BB, Paige CJ, Bender TP, McNamara CA, Husain M, Robbins CS. c-Myb Exacerbates Atherosclerosis through Regulation of Protective IgM-Producing Antibody-Secreting Cells. Cell Rep. 2019 05 21; 27(8):2304-2312.e6. PMID: 31116977.
    Citations: 1     Fields:    Translation:AnimalsCells
  27. Mindur JE, Swirski FK. Growth Factors as Immunotherapeutic Targets in Cardiovascular Disease. Arterioscler Thromb Vasc Biol. 2019 07; 39(7):1275-1287. PMID: 31092009.
    Citations: 4     Fields:    Translation:Humans
  28. Courties G, Frodermann V, Honold L, Zheng Y, Herisson F, Schloss MJ, Sun Y, Presumey J, Severe N, Engblom C, Hulsmans M, Cremer S, Rohde D, Pittet MJ, Scadden DT, Swirski FK, Kim DE, Moskowitz MA, Nahrendorf M. Glucocorticoids Regulate Bone Marrow B Lymphopoiesis After Stroke. Circ Res. 2019 04 26; 124(9):1372-1385. PMID: 30782088.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  29. McAlpine CS, Kiss MG, Rattik S, He S, Vassalli A, Valet C, Anzai A, Chan CT, Mindur JE, Kahles F, Poller WC, Frodermann V, Fenn AM, Gregory AF, Halle L, Iwamoto Y, Hoyer FF, Binder CJ, Libby P, Tafti M, Scammell TE, Nahrendorf M, Swirski FK. Sleep modulates haematopoiesis and protects against atherosclerosis. Nature. 2019 02; 566(7744):383-387. PMID: 30760925.
    Citations: 64     Fields:    Translation:AnimalsCells
  30. He S, Kahles F, Rattik S, Nairz M, McAlpine CS, Anzai A, Selgrade D, Fenn AM, Chan CT, Mindur JE, Valet C, Poller WC, Halle L, Rotllan N, Iwamoto Y, Wojtkiewicz GR, Weissleder R, Libby P, Fernández-Hernando C, Drucker DJ, Nahrendorf M, Swirski FK. Gut intraepithelial T cells calibrate metabolism and accelerate cardiovascular disease. Nature. 2019 02; 566(7742):115-119. PMID: 30700910.
    Citations: 23     Fields:    Translation:AnimalsCells
  31. Anzai A, Mindur JE, Halle L, Sano S, Choi JL, He S, McAlpine CS, Chan CT, Kahles F, Valet C, Fenn AM, Nairz M, Rattik S, Iwamoto Y, Fairweather D, Walsh K, Libby P, Nahrendorf M, Swirski FK. Self-reactive CD4+ IL-3+ T cells amplify autoimmune inflammation in myocarditis by inciting monocyte chemotaxis. J Exp Med. 2019 02 04; 216(2):369-383. PMID: 30670465.
    Citations: 6     Fields:    Translation:AnimalsCells
  32. Swirski FK, Nahrendorf M. Reply to 'Cardioimmunology of arrhythmias: the role of autoimmune and inflammatory cardiac channelopathies'. Nat Rev Immunol. 2019 01; 19(1):65. PMID: 30552386.
    Citations:    Fields:    Translation:Humans
  33. Swirski FK, Nahrendorf M. Cardioimmunology: the immune system in cardiac homeostasis and disease. Nat Rev Immunol. 2018 12; 18(12):733-744. PMID: 30228378.
    Citations: 103     Fields:    Translation:HumansAnimalsCells
  34. Hulsmans M, Aguirre AD, Bonner MD, Bapat A, Cremer S, Iwamoto Y, King KR, Swirski FK, Milan DJ, Weissleder R, Nahrendorf M. A Miniaturized, Programmable Pacemaker for Long-Term Studies in the Mouse. Circ Res. 2018 11 09; 123(11):1208-1219. PMID: 30571465.
    Citations: 3     Fields:    Translation:Animals
  35. Braza MS, van Leent MMT, Lameijer M, Sanchez-Gaytan BL, Arts RJW, Pérez-Medina C, Conde P, Garcia MR, Gonzalez-Perez M, Brahmachary M, Fay F, Kluza E, Kossatz S, Dress RJ, Salem F, Rialdi A, Reiner T, Boros P, Strijkers GJ, Calcagno CC, Ginhoux F, Marazzi I, Lutgens E, Nicolaes GAF, Weber C, Swirski FK, Nahrendorf M, Fisher EA, Duivenvoorden R, Fayad ZA, Netea MG, Mulder WJM, Ochando J. Inhibiting Inflammation with Myeloid Cell-Specific Nanobiologics Promotes Organ Transplant Acceptance. Immunity. 2018 11 20; 49(5):819-828.e6. PMID: 30413362.
    Citations: 44     Fields:    Translation:AnimalsCells
  36. Fayad ZA, Swirski FK, Calcagno C, Robbins CS, Mulder W, Kovacic JC. Monocyte and Macrophage Dynamics in the Cardiovascular System: JACC Macrophage in CVD Series (Part 3). J Am Coll Cardiol. 2018 10 30; 72(18):2198-2212. PMID: 30360828.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  37. Herisson F, Frodermann V, Courties G, Rohde D, Sun Y, Vandoorne K, Wojtkiewicz GR, Masson GS, Vinegoni C, Kim J, Kim DE, Weissleder R, Swirski FK, Moskowitz MA, Nahrendorf M. Direct vascular channels connect skull bone marrow and the brain surface enabling myeloid cell migration. Nat Neurosci. 2018 09; 21(9):1209-1217. PMID: 30150661.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  38. Vandoorne K, Rohde D, Kim HY, Courties G, Wojtkiewicz G, Honold L, Hoyer FF, Frodermann V, Nayar R, Herisson F, Jung Y, Désogère PA, Vinegoni C, Caravan P, Weissleder R, Sosnovik DE, Lin CP, Swirski FK, Nahrendorf M. Imaging the Vascular Bone Marrow Niche During Inflammatory Stress. Circ Res. 2018 08 03; 123(4):415-427. PMID: 29980569.
    Citations: 13     Fields:    Translation:AnimalsCells
  39. Swirski FK. Rings of Fire. Arterioscler Thromb Vasc Biol. 2018 08; 38(8):1671-1672. PMID: 30354199.
    Citations:    Fields:    Translation:AnimalsCells
  40. Lameijer M, Binderup T, van Leent MMT, Senders ML, Fay F, Malkus J, Sanchez-Gaytan BL, Teunissen AJP, Karakatsanis N, Robson P, Zhou X, Ye Y, Wojtkiewicz G, Tang J, Seijkens TTP, Kroon J, Stroes ESG, Kjaer A, Ochando J, Reiner T, Pérez-Medina C, Calcagno C, Fisher EA, Zhang B, Temel RE, Swirski FK, Nahrendorf M, Fayad ZA, Lutgens E, Mulder WJM, Duivenvoorden R. Author Correction: Efficacy and safety assessment of a TRAF6-targeted nanoimmunotherapy in atherosclerotic mice and non-human primates. Nat Biomed Eng. 2018 Aug; 2(8):623. PMID: 31015637.
    Citations:    Fields:    
  41. Swirski FK. A CRISPR Take on Clonal Hematopoiesis. Circ Res. 2018 07 20; 123(3):313-314. PMID: 30026373.
    Citations:    Fields:    Translation:HumansCells
  42. Yvan-Charvet L, Swirski FK. Is defective cholesterol efflux an integral inflammatory component in myelopoiesis-driven cardiovascular diseases? Eur Heart J. 2018 06 14; 39(23):2168-2171. PMID: 29771312.
    Citations: 1     Fields:    Translation:HumansCells
  43. Zhang Y, Dong H, Seeburg DP, Wojtkiewicz GR, Waterman P, Pulli B, Forghani R, Ali M, Iwamoto Y, Swirski FK, Chen JW. Multimodal Molecular Imaging Demonstrates Myeloperoxidase Regulation of Matrix Metalloproteinase Activity in Neuroinflammation. Mol Neurobiol. 2019 Feb; 56(2):954-962. PMID: 29808380.
    Citations: 5     Fields:    Translation:Animals
  44. Lameijer M, Binderup T, van Leent MMT, Senders ML, Fay F, Malkus J, Sanchez-Gaytan BL, Teunissen AJP, Karakatsanis N, Robson P, Zhou X, Ye Y, Wojtkiewicz G, Tang J, Seijkens TTP, Kroon J, Stroes ESG, Kjaer A, Ochando J, Reiner T, Pérez-Medina C, Calcagno C, Fisher EA, Zhang B, Temel RE, Swirski FK, Nahrendorf M, Fayad ZA, Lutgens E, Mulder WJM, Duivenvoorden R. Efficacy and safety assessment of a TRAF6-targeted nanoimmunotherapy in atherosclerotic mice and non-human primates. Nat Biomed Eng. 2018 05; 2(5):279-292. PMID: 30936448.
    Citations: 24     Fields:    Translation:AnimalsCells
  45. Min J, Nothing M, Coble B, Zheng H, Park J, Im H, Weber GF, Castro CM, Swirski FK, Weissleder R, Lee H. Integrated Biosensor for Rapid and Point-of-Care Sepsis Diagnosis. ACS Nano. 2018 04 24; 12(4):3378-3384. PMID: 29533646.
    Citations: 14     Fields:    Translation:Humans
  46. Swirski FK, Nahrendorf M. Clonal Hematopoiesis Wages War on the Myocardium. J Am Coll Cardiol. 2018 02 27; 71(8):887-889. PMID: 29471940.
    Citations:    Fields:    Translation:Humans
  47. Hulsmans M, Sager HB, Roh JD, Valero-Muñoz M, Houstis NE, Iwamoto Y, Sun Y, Wilson RM, Wojtkiewicz G, Tricot B, Osborne MT, Hung J, Vinegoni C, Naxerova K, Sosnovik DE, Zile MR, Bradshaw AD, Liao R, Tawakol A, Weissleder R, Rosenzweig A, Swirski FK, Sam F, Nahrendorf M. Cardiac macrophages promote diastolic dysfunction. J Exp Med. 2018 02 05; 215(2):423-440. PMID: 29339450.
    Citations: 91     Fields:    Translation:HumansAnimalsCells
  48. Swirski FK. Inflammation and CVD in 2017: From clonal haematopoiesis to the CANTOS trial. Nat Rev Cardiol. 2018 02; 15(2):79-80. PMID: 29263444.
    Citations: 9     Fields:    Translation:HumansAnimals
  49. Nairz M, Haschka D, Dichtl S, Sonnweber T, Schroll A, Aßhoff M, Mindur JE, Moser PL, Wolf D, Swirski FK, Theurl I, Cerami A, Brines M, Weiss G. Cibinetide dampens innate immune cell functions thus ameliorating the course of experimental colitis. Sci Rep. 2017 10 12; 7(1):13012. PMID: 29026145.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  50. Anzai A, Choi JL, He S, Fenn AM, Nairz M, Rattik S, McAlpine CS, Mindur JE, Chan CT, Iwamoto Y, Tricot B, Wojtkiewicz GR, Weissleder R, Libby P, Nahrendorf M, Stone JR, Becher B, Swirski FK. The infarcted myocardium solicits GM-CSF for the detrimental oversupply of inflammatory leukocytes. J Exp Med. 2017 Nov 06; 214(11):3293-3310. PMID: 28978634.
    Citations: 59     Fields:    Translation:HumansAnimalsCells
  51. Teague HL, Ahlman MA, Alavi A, Wagner DD, Lichtman AH, Nahrendorf M, Swirski FK, Nestle F, Gelfand JM, Kaplan MJ, Grinspoon S, Ridker PM, Newby DE, Tawakol A, Fayad ZA, Mehta NN. Unraveling Vascular Inflammation: From Immunology to Imaging. J Am Coll Cardiol. 2017 Sep 12; 70(11):1403-1412. PMID: 28882238.
    Citations: 13     Fields:    Translation:Humans
  52. Chousterman BG, Swirski FK, Weber GF. Cytokine storm and sepsis disease pathogenesis. Semin Immunopathol. 2017 07; 39(5):517-528. PMID: 28555385.
    Citations: 235     Fields:    Translation:HumansAnimalsCells
  53. Nahrendorf M, Swirski FK. Cholesterol, CCR2, and monocyte phenotypes in atherosclerosis. Eur Heart J. 2017 05 21; 38(20):1594-1596. PMID: 28329093.
    Citations: 7     Fields:    Translation:HumansCells
  54. Hulsmans M, Clauss S, Xiao L, Aguirre AD, King KR, Hanley A, Hucker WJ, Wülfers EM, Seemann G, Courties G, Iwamoto Y, Sun Y, Savol AJ, Sager HB, Lavine KJ, Fishbein GA, Capen DE, Da Silva N, Miquerol L, Wakimoto H, Seidman CE, Seidman JG, Sadreyev RI, Naxerova K, Mitchell RN, Brown D, Libby P, Weissleder R, Swirski FK, Kohl P, Vinegoni C, Milan DJ, Ellinor PT, Nahrendorf M. Macrophages Facilitate Electrical Conduction in the Heart. Cell. 2017 04 20; 169(3):510-522.e20. PMID: 28431249.
    Citations: 212     Fields:    Translation:HumansAnimalsCells
  55. Franck G, Mawson T, Sausen G, Salinas M, Masson GS, Cole A, Beltrami-Moreira M, Chatzizisis Y, Quillard T, Tesmenitsky Y, Shvartz E, Sukhova GK, Swirski FK, Nahrendorf M, Aikawa E, Croce KJ, Libby P. Flow Perturbation Mediates Neutrophil Recruitment and Potentiates Endothelial Injury via TLR2 in Mice: Implications for Superficial Erosion. Circ Res. 2017 Jun 23; 121(1):31-42. PMID: 28428204.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  56. Swirski FK, Nahrendorf M. Inflammation: Old, caffeinated, and healthy. Nat Rev Cardiol. 2017 04; 14(4):194-196. PMID: 28250451.
    Citations: 2     Fields:    Translation:Humans
  57. Nairz M, Theurl I, Swirski FK, Weiss G. "Pumping iron"-how macrophages handle iron at the systemic, microenvironmental, and cellular levels. Pflugers Arch. 2017 04; 469(3-4):397-418. PMID: 28251312.
    Citations: 47     Fields:    Translation:HumansAnimalsCells
  58. Zhang Y, Seeburg DP, Pulli B, Wojtkiewicz GR, Bure L, Atkinson W, Schob S, Iwamoto Y, Ali M, Zhang W, Rodriguez E, Milewski A, Keliher EJ, Wang C, Pan Y, Swirski FK, Chen JW. Myeloperoxidase Nuclear Imaging for Epileptogenesis. Radiology. 2017 02; 282(2):614. PMID: 28099101.
    Citations:    Fields:    
  59. Fenn AM, Swirski FK. Monocytosis, Hypercholesterolemia, and the Kinase That Binds Them. Arterioscler Thromb Vasc Biol. 2017 02; 37(2):173-175. PMID: 28122772.
    Citations:    Fields:    Translation:AnimalsCells
  60. Keliher EJ, Ye YX, Wojtkiewicz GR, Aguirre AD, Tricot B, Senders ML, Groenen H, Fay F, Perez-Medina C, Calcagno C, Carlucci G, Reiner T, Sun Y, Courties G, Iwamoto Y, Kim HY, Wang C, Chen JW, Swirski FK, Wey HY, Hooker J, Fayad ZA, Mulder WJ, Weissleder R, Nahrendorf M. Polyglucose nanoparticles with renal elimination and macrophage avidity facilitate PET imaging in ischaemic heart disease. Nat Commun. 2017 01 16; 8:14064. PMID: 28091604.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  61. Ali M, Pulli B, Courties G, Tricot B, Sebas M, Iwamoto Y, Hilgendorf I, Schob S, Dong A, Zheng W, Skoura A, Kalgukar A, Cortes C, Ruggeri R, Swirski FK, Nahrendorf M, Buckbinder L, Chen JW. Myeloperoxidase Inhibition Improves Ventricular Function and Remodeling After Experimental Myocardial Infarction. JACC Basic Transl Sci. 2016 Dec; 1(7):633-643. PMID: 30167547.
    Citations: 19     
  62. Canali S, Zumbrennen-Bullough KB, Core AB, Wang CY, Nairz M, Bouley R, Swirski FK, Babitt JL. Endothelial cells produce bone morphogenetic protein 6 required for iron homeostasis in mice. Blood. 2017 01 26; 129(4):405-414. PMID: 27864295.
    Citations: 67     Fields:    Translation:AnimalsCells
  63. Tang J, Baxter S, Menon A, Alaarg A, Sanchez-Gaytan BL, Fay F, Zhao Y, Ouimet M, Braza MS, Longo VA, Abdel-Atti D, Duivenvoorden R, Calcagno C, Storm G, Tsimikas S, Moore KJ, Swirski FK, Nahrendorf M, Fisher EA, Pérez-Medina C, Fayad ZA, Reiner T, Mulder WJ. Immune cell screening of a nanoparticle library improves atherosclerosis therapy. Proc Natl Acad Sci U S A. 2016 11 01; 113(44):E6731-E6740. PMID: 27791119.
    Citations: 23     Fields:    Translation:AnimalsCells
  64. Swirski FK, Nahrendorf M. Bone Marrow Takes Center Stage in Cardiovascular Disease. Circ Res. 2016 09 02; 119(6):701-3. PMID: 27587406.
    Citations: 6     Fields:    Translation:HumansCells
  65. Swirski FK, Nahrendorf M, Libby P. Mechanisms of Myeloid Cell Modulation of Atherosclerosis. Microbiol Spectr. 2016 08; 4(4). PMID: 27726819.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  66. Dutta P, Hoyer FF, Sun Y, Iwamoto Y, Tricot B, Weissleder R, Magnani JL, Swirski FK, Nahrendorf M. E-Selectin Inhibition Mitigates Splenic HSC Activation and Myelopoiesis in Hypercholesterolemic Mice With Myocardial Infarction. Arterioscler Thromb Vasc Biol. 2016 09; 36(9):1802-8. PMID: 27470513.
    Citations: 13     Fields:    Translation:AnimalsCells
  67. Aryal B, Rotllan N, Araldi E, Ramírez CM, He S, Chousterman BG, Fenn AM, Wanschel A, Madrigal-Matute J, Warrier N, Martín-Ventura JL, Swirski FK, Suárez Y, Fernández-Hernando C. ANGPTL4 deficiency in haematopoietic cells promotes monocyte expansion and atherosclerosis progression. Nat Commun. 2016 07 27; 7:12313. PMID: 27460411.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  68. Libby P, Nahrendorf M, Swirski FK. Reply: The Networks Between the Sympathetic Nervous System and Immune System in Atherosclerosis. J Am Coll Cardiol. 2016 07 26; 68(4):432. PMID: 27443446.
    Citations:    Fields:    Translation:Humans
  69. Nahrendorf M, Swirski FK. Abandoning M1/M2 for a Network Model of Macrophage Function. Circ Res. 2016 07 22; 119(3):414-7. PMID: 27458196.
    Citations: 96     Fields:    Translation:HumansAnimalsCells
  70. Sager HB, Hulsmans M, Lavine KJ, Moreira MB, Heidt T, Courties G, Sun Y, Iwamoto Y, Tricot B, Khan OF, Dahlman JE, Borodovsky A, Fitzgerald K, Anderson DG, Weissleder R, Libby P, Swirski FK, Nahrendorf M. Proliferation and Recruitment Contribute to Myocardial Macrophage Expansion in Chronic Heart Failure. Circ Res. 2016 Sep 16; 119(7):853-64. PMID: 27444755.
    Citations: 117     Fields:    Translation:HumansAnimalsCells
  71. Theurl I, Hilgendorf I, Nairz M, Tymoszuk P, Haschka D, Asshoff M, He S, Gerhardt LM, Holderried TA, Seifert M, Sopper S, Fenn AM, Anzai A, Rattik S, McAlpine C, Theurl M, Wieghofer P, Iwamoto Y, Weber GF, Harder NK, Chousterman BG, Arvedson TL, McKee M, Wang F, Lutz OM, Rezoagli E, Babitt JL, Berra L, Prinz M, Nahrendorf M, Weiss G, Weissleder R, Lin HY, Swirski FK. On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver. Nat Med. 2016 08; 22(8):945-51. PMID: 27428900.
    Citations: 103     Fields:    Translation:AnimalsCells
  72. McAlpine CS, Swirski FK. Circadian Influence on Metabolism and Inflammation in Atherosclerosis. Circ Res. 2016 06 24; 119(1):131-41. PMID: 27340272.
    Citations: 22     Fields:    Translation:HumansAnimals
  73. Sager HB, Dutta P, Dahlman JE, Hulsmans M, Courties G, Sun Y, Heidt T, Vinegoni C, Borodovsky A, Fitzgerald K, Wojtkiewicz GR, Iwamoto Y, Tricot B, Khan OF, Kauffman KJ, Xing Y, Shaw TE, Libby P, Langer R, Weissleder R, Swirski FK, Anderson DG, Nahrendorf M. RNAi targeting multiple cell adhesion molecules reduces immune cell recruitment and vascular inflammation after myocardial infarction. Sci Transl Med. 2016 06 08; 8(342):342ra80. PMID: 27280687.
    Citations: 50     Fields:    Translation:AnimalsCells
  74. Libby P, Nahrendorf M, Swirski FK. Leukocytes Link Local and Systemic Inflammation in Ischemic Cardiovascular Disease: An Expanded "Cardiovascular Continuum". J Am Coll Cardiol. 2016 Mar 08; 67(9):1091-1103. PMID: 26940931.
    Citations: 82     Fields:    Translation:HumansCells
  75. Lindau A, Härdtner C, Hergeth SP, Blanz KD, Dufner B, Hoppe N, Anto-Michel N, Kornemann J, Zou J, Gerhardt LM, Heidt T, Willecke F, Geis S, Stachon P, Wolf D, Libby P, Swirski FK, Robbins CS, McPheat W, Hawley S, Braddock M, Gilsbach R, Hein L, von zur Mühlen C, Bode C, Zirlik A, Hilgendorf I. Atheroprotection through SYK inhibition fails in established disease when local macrophage proliferation dominates lesion progression. Basic Res Cardiol. 2016 Mar; 111(2):20. PMID: 26891724.
    Citations: 9     Fields:    Translation:AnimalsCells
  76. Swirski FK, Robbins CS, Nahrendorf M. Development and Function of Arterial and Cardiac Macrophages. Trends Immunol. 2016 Jan; 37(1):32-40. PMID: 26748179.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  77. Ensan S, Li A, Besla R, Degousee N, Cosme J, Roufaiel M, Shikatani EA, El-Maklizi M, Williams JW, Robins L, Li C, Lewis B, Yun TJ, Lee JS, Wieghofer P, Khattar R, Farrokhi K, Byrne J, Ouzounian M, Zavitz CC, Levy GA, Bauer CM, Libby P, Husain M, Swirski FK, Cheong C, Prinz M, Hilgendorf I, Randolph GJ, Epelman S, Gramolini AO, Cybulsky MI, Rubin BB, Robbins CS. Self-renewing resident arterial macrophages arise from embryonic CX3CR1(+) precursors and circulating monocytes immediately after birth. Nat Immunol. 2016 Feb; 17(2):159-68. PMID: 26642357.
    Citations: 101     Fields:    Translation:AnimalsCells
  78. Nahrendorf M, Swirski FK. PET Imaging of Leukocytes in Patients With Acute Myocardial Infarction. JACC Cardiovasc Imaging. 2015 Dec; 8(12):1427-1429. PMID: 26699111.
    Citations: 1     Fields:    Translation:HumansCells
  79. Zhang Y, Seeburg DP, Pulli B, Wojtkiewicz GR, Bure L, Atkinson W, Schob S, Iwamoto Y, Ali M, Zhang W, Rodriguez E, Milewski A, Keliher EJ, Wang C, Pan Y, Swirski FK, Chen JW. Myeloperoxidase Nuclear Imaging for Epileptogenesis. Radiology. 2016 Mar; 278(3):822-30. PMID: 26397127.
    Citations: 6     Fields:    Translation:Animals
  80. Ye YX, Calcagno C, Binderup T, Courties G, Keliher EJ, Wojtkiewicz GR, Iwamoto Y, Tang J, Pérez-Medina C, Mani V, Ishino S, Johnbeck CB, Knigge U, Fayad ZA, Libby P, Weissleder R, Tawakol A, Dubey S, Belanger AP, Di Carli MF, Swirski FK, Kjaer A, Mulder WJ, Nahrendorf M. Imaging Macrophage and Hematopoietic Progenitor Proliferation in Atherosclerosis. Circ Res. 2015 Oct 23; 117(10):835-45. PMID: 26394773.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  81. Sager HB, Heidt T, Hulsmans M, Dutta P, Courties G, Sebas M, Wojtkiewicz GR, Tricot B, Iwamoto Y, Sun Y, Weissleder R, Libby P, Swirski FK, Nahrendorf M. Targeting Interleukin-1ß Reduces Leukocyte Production After Acute Myocardial Infarction. Circulation. 2015 Nov 17; 132(20):1880-90. PMID: 26358260.
    Citations: 78     Fields:    Translation:AnimalsCells
  82. Nahrendorf M, Swirski FK. Innate immune cells in ischaemic heart disease: does myocardial infarction beget myocardial infarction? Eur Heart J. 2016 Mar 14; 37(11):868-72. PMID: 26351395.
    Citations: 23     Fields:    Translation:HumansCells
  83. He S, Chousterman BG, Fenn A, Anzai A, Nairz M, Brandt M, Hilgendorf I, Sun Y, Ye YX, Iwamoto Y, Tricot B, Weissleder R, Macphee C, Libby P, Nahrendorf M, Swirski FK. Lp-PLA2 Antagonizes Left Ventricular Healing After Myocardial Infarction by Impairing the Appearance of Reparative Macrophages. Circ Heart Fail. 2015 Sep; 8(5):980-7. PMID: 26232205.
    Citations: 3     Fields:    Translation:AnimalsCells
  84. Nahrendorf M, Swirski FK. Immunology. Neutrophil-macrophage communication in inflammation and atherosclerosis. Science. 2015 Jul 17; 349(6245):237-8. PMID: 26185231.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  85. Tacke R, Hilgendorf I, Garner H, Waterborg C, Park K, Nowyhed H, Hanna RN, Wu R, Swirski FK, Geissmann F, Hedrick CC. The transcription factor NR4A1 is essential for the development of a novel macrophage subset in the thymus. Sci Rep. 2015 Jun 19; 5:10055. PMID: 26091486.
    Citations: 11     Fields:    Translation:AnimalsCells
  86. Chousterman BG, Swirski FK. Innate response activator B cells: origins and functions. Int Immunol. 2015 Oct; 27(10):537-41. PMID: 25957266.
    Citations: 9     Fields:    Translation:AnimalsCells
  87. Dutta P, Sager HB, Stengel KR, Naxerova K, Courties G, Saez B, Silberstein L, Heidt T, Sebas M, Sun Y, Wojtkiewicz G, Feruglio PF, King K, Baker JN, van der Laan AM, Borodovsky A, Fitzgerald K, Hulsmans M, Hoyer F, Iwamoto Y, Vinegoni C, Brown D, Di Carli M, Libby P, Hiebert SW, Scadden DT, Swirski FK, Weissleder R, Nahrendorf M. Myocardial Infarction Activates CCR2(+) Hematopoietic Stem and Progenitor Cells. Cell Stem Cell. 2015 May 07; 16(5):477-87. PMID: 25957903.
    Citations: 78     Fields:    Translation:AnimalsCells
  88. Nahrendorf M, Frantz S, Swirski FK, Mulder WJ, Randolph G, Ertl G, Ntziachristos V, Piek JJ, Stroes ES, Schwaiger M, Mann DL, Fayad ZA. Imaging systemic inflammatory networks in ischemic heart disease. J Am Coll Cardiol. 2015 Apr 21; 65(15):1583-91. PMID: 25881940.
    Citations: 24     Fields:    Translation:HumansCells
  89. Tang J, Lobatto ME, Hassing L, van der Staay S, van Rijs SM, Calcagno C, Braza MS, Baxter S, Fay F, Sanchez-Gaytan BL, Duivenvoorden R, Sager H, Astudillo YM, Leong W, Ramachandran S, Storm G, Pérez-Medina C, Reiner T, Cormode DP, Strijkers GJ, Stroes ES, Swirski FK, Nahrendorf M, Fisher EA, Fayad ZA, Mulder WJ. Inhibiting macrophage proliferation suppresses atherosclerotic plaque inflammation. Sci Adv. 2015 Apr; 1(3). PMID: 26295063.
    Citations: 56     Fields:    
  90. Dutta P, Hoyer FF, Grigoryeva LS, Sager HB, Leuschner F, Courties G, Borodovsky A, Novobrantseva T, Ruda VM, Fitzgerald K, Iwamoto Y, Wojtkiewicz G, Sun Y, Da Silva N, Libby P, Anderson DG, Swirski FK, Weissleder R, Nahrendorf M. Macrophages retain hematopoietic stem cells in the spleen via VCAM-1. J Exp Med. 2015 Apr 06; 212(4):497-512. PMID: 25800955.
    Citations: 59     Fields:    Translation:AnimalsCells
  91. Weber GF, Chousterman BG, He S, Fenn AM, Nairz M, Anzai A, Brenner T, Uhle F, Iwamoto Y, Robbins CS, Noiret L, Maier SL, Zönnchen T, Rahbari NN, Schölch S, Klotzsche-von Ameln A, Chavakis T, Weitz J, Hofer S, Weigand MA, Nahrendorf M, Weissleder R, Swirski FK. Interleukin-3 amplifies acute inflammation and is a potential therapeutic target in sepsis. Science. 2015 Mar 13; 347(6227):1260-5. PMID: 25766237.
    Citations: 92     Fields:    Translation:HumansAnimalsCells
  92. Nahrendorf M, Swirski FK. Lifestyle effects on hematopoiesis and atherosclerosis. Circ Res. 2015 Feb 27; 116(5):884-94. PMID: 25722442.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  93. Hilgendorf I, Swirski FK, Robbins CS. Monocyte fate in atherosclerosis. Arterioscler Thromb Vasc Biol. 2015 Feb; 35(2):272-9. PMID: 25538208.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  94. Swirski FK. Inflammation and repair in the ischaemic myocardium. Hamostaseologie. 2015; 35(1):34-6. PMID: 25375277.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  95. Courties G, Herisson F, Sager HB, Heidt T, Ye Y, Wei Y, Sun Y, Severe N, Dutta P, Scharff J, Scadden DT, Weissleder R, Swirski FK, Moskowitz MA, Nahrendorf M. Ischemic stroke activates hematopoietic bone marrow stem cells. Circ Res. 2015 Jan 30; 116(3):407-17. PMID: 25362208.
    Citations: 60     Fields:    Translation:AnimalsCells
  96. Swirski FK, Nahrendorf M. Do vascular smooth muscle cells differentiate to macrophages in atherosclerotic lesions? Circ Res. 2014 Sep 12; 115(7):605-6. PMID: 25214571.
    Citations: 10     Fields:    Translation:AnimalsCells
  97. Nahrendorf M, Swirski FK. Imaging systemic inflammation in patients with acute myocardial infarction. Circ Cardiovasc Imaging. 2014 Sep; 7(5):762-4. PMID: 25227235.
    Citations:    Fields:    Translation:Humans
  98. Heidt T, Sager HB, Courties G, Dutta P, Iwamoto Y, Zaltsman A, von Zur Muhlen C, Bode C, Fricchione GL, Denninger J, Lin CP, Vinegoni C, Libby P, Swirski FK, Weissleder R, Nahrendorf M. Chronic variable stress activates hematopoietic stem cells. Nat Med. 2014 Jul; 20(7):754-758. PMID: 24952646.
    Citations: 222     Fields:    Translation:HumansAnimalsCells
  99. Leuschner F, Courties G, Dutta P, Mortensen LJ, Gorbatov R, Sena B, Novobrantseva TI, Borodovsky A, Fitzgerald K, Koteliansky V, Iwamoto Y, Bohlender M, Meyer S, Lasitschka F, Meder B, Katus HA, Lin C, Libby P, Swirski FK, Anderson DG, Weissleder R, Nahrendorf M. Silencing of CCR2 in myocarditis. Eur Heart J. 2015 Jun 14; 36(23):1478-88. PMID: 24950695.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  100. Nahrendorf M, Swirski FK. Regulating repair: regulatory T cells in myocardial infarction. Circ Res. 2014 Jun 20; 115(1):7-9. PMID: 24951758.
    Citations: 6     Fields:    Translation:AnimalsCells
  101. Weber GF, Chousterman BG, Hilgendorf I, Robbins CS, Theurl I, Gerhardt LM, Iwamoto Y, Quach TD, Ali M, Chen JW, Rothstein TL, Nahrendorf M, Weissleder R, Swirski FK. Pleural innate response activator B cells protect against pneumonia via a GM-CSF-IgM axis. J Exp Med. 2014 Jun 02; 211(6):1243-56. PMID: 24821911.
    Citations: 64     Fields:    Translation:HumansAnimalsCells
  102. Heidt T, Courties G, Dutta P, Sager HB, Sebas M, Iwamoto Y, Sun Y, Da Silva N, Panizzi P, van der Laan AM, van der Lahn AM, Swirski FK, Weissleder R, Nahrendorf M. Differential contribution of monocytes to heart macrophages in steady-state and after myocardial infarction. Circ Res. 2014 Jul 07; 115(2):284-95. PMID: 24786973.
    Citations: 171     Fields:    Translation:HumansAnimalsCells
  103. Pittet MJ, Nahrendorf M, Swirski FK. The journey from stem cell to macrophage. Ann N Y Acad Sci. 2014 Jun; 1319:1-18. PMID: 24673186.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  104. Hilgendorf I, Gerhardt LM, Tan TC, Winter C, Holderried TA, Chousterman BG, Iwamoto Y, Liao R, Zirlik A, Scherer-Crosbie M, Hedrick CC, Libby P, Nahrendorf M, Weissleder R, Swirski FK. Ly-6Chigh monocytes depend on Nr4a1 to balance both inflammatory and reparative phases in the infarcted myocardium. Circ Res. 2014 May 09; 114(10):1611-22. PMID: 24625784.
    Citations: 187     Fields:    Translation:AnimalsCells
  105. Nahrendorf M, Swirski FK. Fluorescent leukocytes enter plaque on the microscope stage. Circ Res. 2014 Feb 28; 114(5):740-1. PMID: 24577957.
    Citations:    Fields:    Translation:Animals
  106. Swirski FK. Monocyte recruitment and macrophage proliferation in atherosclerosis. Kardiol Pol. 2014; 72(4):311-4. PMID: 24526549.
    Citations: 2     Fields:    Translation:HumansCells
  107. Hilgendorf I, Theurl I, Gerhardt LM, Robbins CS, Weber GF, Gonen A, Iwamoto Y, Degousee N, Holderried TA, Winter C, Zirlik A, Lin HY, Sukhova GK, Butany J, Rubin BB, Witztum JL, Libby P, Nahrendorf M, Weissleder R, Swirski FK. Innate response activator B cells aggravate atherosclerosis by stimulating T helper-1 adaptive immunity. Circulation. 2014 Apr 22; 129(16):1677-87. PMID: 24488984.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  108. Swirski FK, Hilgendorf I, Robbins CS. From proliferation to proliferation: monocyte lineage comes full circle. Semin Immunopathol. 2014 Mar; 36(2):137-48. PMID: 24435095.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  109. Kobzik L, Swirski FK. MARCOing monocytes for elimination. Sci Transl Med. 2014 Jan 15; 6(219):219fs4. PMID: 24431109.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  110. Weber GF, Swirski FK. Immunopathogenesis of abdominal sepsis. Langenbecks Arch Surg. 2014 Jan; 399(1):1-9. PMID: 24121723.
    Citations: 15     Fields:    Translation:HumansAnimals
  111. Courties G, Heidt T, Sebas M, Iwamoto Y, Jeon D, Truelove J, Tricot B, Wojtkiewicz G, Dutta P, Sager HB, Borodovsky A, Novobrantseva T, Klebanov B, Fitzgerald K, Anderson DG, Libby P, Swirski FK, Weissleder R, Nahrendorf M. In vivo silencing of the transcription factor IRF5 reprograms the macrophage phenotype and improves infarct healing. J Am Coll Cardiol. 2014 Apr 22; 63(15):1556-66. PMID: 24361318.
    Citations: 103     Fields:    Translation:AnimalsCells
  112. Wildgruber M, Swirski FK, Zernecke A. Molecular imaging of inflammation in atherosclerosis. Theranostics. 2013 Nov 01; 3(11):865-84. PMID: 24312156.
    Citations: 33     Fields:    Translation:Humans
  113. Swirski FK, Nahrendorf M. Macrophage-stem cell crosstalk after myocardial infarction. J Am Coll Cardiol. 2013 Nov 12; 62(20):1902-4. PMID: 23973700.
    Citations: 6     Fields:    Translation:AnimalsCells
  114. Robbins CS, Hilgendorf I, Weber GF, Theurl I, Iwamoto Y, Figueiredo JL, Gorbatov R, Sukhova GK, Gerhardt LM, Smyth D, Zavitz CC, Shikatani EA, Parsons M, van Rooijen N, Lin HY, Husain M, Libby P, Nahrendorf M, Weissleder R, Swirski FK. Local proliferation dominates lesional macrophage accumulation in atherosclerosis. Nat Med. 2013 Sep; 19(9):1166-72. PMID: 23933982.
    Citations: 313     Fields:    Translation:AnimalsCells
  115. Libby P, Nahrendorf M, Swirski FK. Monocyte heterogeneity in cardiovascular disease. Semin Immunopathol. 2013 Sep; 35(5):553-62. PMID: 23839097.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  116. Ueno T, Dutta P, Keliher E, Leuschner F, Majmudar M, Marinelli B, Iwamoto Y, Figueiredo JL, Christen T, Swirski FK, Libby P, Weissleder R, Nahrendorf M. Nanoparticle PET-CT detects rejection and immunomodulation in cardiac allografts. Circ Cardiovasc Imaging. 2013 Jul; 6(4):568-73. PMID: 23771986.
    Citations: 15     Fields:    Translation:AnimalsCells
  117. Nahrendorf M, Swirski FK. Monocyte and macrophage heterogeneity in the heart. Circ Res. 2013 Jun 07; 112(12):1624-33. PMID: 23743228.
    Citations: 111     Fields:    Translation:HumansAnimalsCells
  118. Majmudar MD, Keliher EJ, Heidt T, Leuschner F, Truelove J, Sena BF, Gorbatov R, Iwamoto Y, Dutta P, Wojtkiewicz G, Courties G, Sebas M, Borodovsky A, Fitzgerald K, Nolte MW, Dickneite G, Chen JW, Anderson DG, Swirski FK, Weissleder R, Nahrendorf M. Monocyte-directed RNAi targeting CCR2 improves infarct healing in atherosclerosis-prone mice. Circulation. 2013 May 21; 127(20):2038-46. PMID: 23616627.
    Citations: 99     Fields:    Translation:AnimalsCells
  119. Swirski FK, Robbins CS. Neutrophils usher monocytes into sites of inflammation. Circ Res. 2013 Mar 01; 112(5):744-5. PMID: 23449542.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  120. Cortez-Retamozo V, Etzrodt M, Newton A, Ryan R, Pucci F, Sio SW, Kuswanto W, Rauch PJ, Chudnovskiy A, Iwamoto Y, Kohler R, Marinelli B, Gorbatov R, Wojtkiewicz G, Panizzi P, Mino-Kenudson M, Forghani R, Figueiredo JL, Chen JW, Xavier R, Swirski FK, Nahrendorf M, Weissleder R, Pittet MJ. Angiotensin II drives the production of tumor-promoting macrophages. Immunity. 2013 Feb 21; 38(2):296-308. PMID: 23333075.
    Citations: 74     Fields:    Translation:HumansAnimalsCells
  121. Swirski FK, Nahrendorf M. Leukocyte behavior in atherosclerosis, myocardial infarction, and heart failure. Science. 2013 Jan 11; 339(6116):161-6. PMID: 23307733.
    Citations: 305     Fields:    Translation:HumansAnimalsCells
  122. Majmudar MD, Yoo J, Keliher EJ, Truelove JJ, Iwamoto Y, Sena B, Dutta P, Borodovsky A, Fitzgerald K, Di Carli MF, Libby P, Anderson DG, Swirski FK, Weissleder R, Nahrendorf M. Polymeric nanoparticle PET/MR imaging allows macrophage detection in atherosclerotic plaques. Circ Res. 2013 Mar 01; 112(5):755-61. PMID: 23300273.
    Citations: 59     Fields:    Translation:AnimalsCells
  123. Soehnlein O, Swirski FK. Hypercholesterolemia links hematopoiesis with atherosclerosis. Trends Endocrinol Metab. 2013 Mar; 24(3):129-36. PMID: 23228326.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  124. Swirski FK, Nahrendorf M. Imaging macrophage development and fate in atherosclerosis and myocardial infarction. Immunol Cell Biol. 2013 Apr; 91(4):297-303. PMID: 23207281.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  125. Hilgendorf I, Swirski FK. Making a difference: monocyte heterogeneity in cardiovascular disease. Curr Atheroscler Rep. 2012 Oct; 14(5):450-9. PMID: 22847772.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  126. Hilgendorf I, Swirski FK. Folate receptor: a macrophage "achilles' heel"? J Am Heart Assoc. 2012 Aug; 1(4):e004036. PMID: 23130179.
    Citations: 3     Fields:    
  127. Dutta P, Courties G, Wei Y, Leuschner F, Gorbatov R, Robbins CS, Iwamoto Y, Thompson B, Carlson AL, Heidt T, Majmudar MD, Lasitschka F, Etzrodt M, Waterman P, Waring MT, Chicoine AT, van der Laan AM, Niessen HW, Piek JJ, Rubin BB, Butany J, Stone JR, Katus HA, Murphy SA, Morrow DA, Sabatine MS, Vinegoni C, Moskowitz MA, Pittet MJ, Libby P, Lin CP, Swirski FK, Weissleder R, Nahrendorf M. Myocardial infarction accelerates atherosclerosis. Nature. 2012 Jul 19; 487(7407):325-9. PMID: 22763456.
    Citations: 336     Fields:    Translation:AnimalsCells
  128. Robbins CS, Swirski FK. Newly discovered innate response activator B cells: crucial responders against microbial sepsis. Expert Rev Clin Immunol. 2012 Jul; 8(5):405-7. PMID: 22882214.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  129. Fukuda D, Aikawa E, Swirski FK, Novobrantseva TI, Kotelianski V, Gorgun CZ, Chudnovskiy A, Yamazaki H, Croce K, Weissleder R, Aster JC, Hotamisligil GS, Yagita H, Aikawa M. Notch ligand delta-like 4 blockade attenuates atherosclerosis and metabolic disorders. Proc Natl Acad Sci U S A. 2012 Jul 03; 109(27):E1868-77. PMID: 22699504.
    Citations: 62     Fields:    Translation:HumansAnimalsCells
  130. Etzrodt M, Cortez-Retamozo V, Newton A, Zhao J, Ng A, Wildgruber M, Romero P, Wurdinger T, Xavier R, Geissmann F, Meylan E, Nahrendorf M, Swirski FK, Baltimore D, Weissleder R, Pittet MJ. Regulation of monocyte functional heterogeneity by miR-146a and Relb. Cell Rep. 2012 Apr 19; 1(4):317-24. PMID: 22545247.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  131. Forghani R, Wojtkiewicz GR, Zhang Y, Seeburg D, Bautz BR, Pulli B, Milewski AR, Atkinson WL, Iwamoto Y, Zhang ER, Etzrodt M, Rodriguez E, Robbins CS, Swirski FK, Weissleder R, Chen JW. Demyelinating diseases: myeloperoxidase as an imaging biomarker and therapeutic target. Radiology. 2012 May; 263(2):451-60. PMID: 22438365.
    Citations: 34     Fields:    Translation:Animals
  132. Swirski FK, Nahrendorf M, Libby P. The ins and outs of inflammatory cells in atheromata. Cell Metab. 2012 Feb 08; 15(2):135-6. PMID: 22326216.
    Citations: 6     Fields:    
  133. Cortez-Retamozo V, Etzrodt M, Newton A, Rauch PJ, Chudnovskiy A, Berger C, Ryan RJ, Iwamoto Y, Marinelli B, Gorbatov R, Forghani R, Novobrantseva TI, Koteliansky V, Figueiredo JL, Chen JW, Anderson DG, Nahrendorf M, Swirski FK, Weissleder R, Pittet MJ. Origins of tumor-associated macrophages and neutrophils. Proc Natl Acad Sci U S A. 2012 Feb 14; 109(7):2491-6. PMID: 22308361.
    Citations: 224     Fields:    Translation:HumansAnimalsCells
  134. Novobrantseva TI, Borodovsky A, Wong J, Klebanov B, Zafari M, Yucius K, Querbes W, Ge P, Ruda VM, Milstein S, Speciner L, Duncan R, Barros S, Basha G, Cullis P, Akinc A, Donahoe JS, Narayanannair Jayaprakash K, Jayaraman M, Bogorad RL, Love K, Whitehead K, Levins C, Manoharan M, Swirski FK, Weissleder R, Langer R, Anderson DG, de Fougerolles A, Nahrendorf M, Koteliansky V. Systemic RNAi-mediated Gene Silencing in Nonhuman Primate and Rodent Myeloid Cells. Mol Ther Nucleic Acids. 2012 Jan 24; 1:e4. PMID: 23344621.
    Citations: 50     
  135. Rauch PJ, Chudnovskiy A, Robbins CS, Weber GF, Etzrodt M, Hilgendorf I, Tiglao E, Figueiredo JL, Iwamoto Y, Theurl I, Gorbatov R, Waring MT, Chicoine AT, Mouded M, Pittet MJ, Nahrendorf M, Weissleder R, Swirski FK. Innate response activator B cells protect against microbial sepsis. Science. 2012 Feb 03; 335(6068):597-601. PMID: 22245738.
    Citations: 162     Fields:    Translation:AnimalsCells
  136. Lee WW, Marinelli B, van der Laan AM, Sena BF, Gorbatov R, Leuschner F, Dutta P, Iwamoto Y, Ueno T, Begieneman MP, Niessen HW, Piek JJ, Vinegoni C, Pittet MJ, Swirski FK, Tawakol A, Di Carli M, Weissleder R, Nahrendorf M. PET/MRI of inflammation in myocardial infarction. J Am Coll Cardiol. 2012 Jan 10; 59(2):153-63. PMID: 22222080.
    Citations: 115     Fields:    Translation:HumansAnimalsCells
  137. Leuschner F, Rauch PJ, Ueno T, Gorbatov R, Marinelli B, Lee WW, Dutta P, Wei Y, Robbins C, Iwamoto Y, Sena B, Chudnovskiy A, Panizzi P, Keliher E, Higgins JM, Libby P, Moskowitz MA, Pittet MJ, Swirski FK, Weissleder R, Nahrendorf M. Rapid monocyte kinetics in acute myocardial infarction are sustained by extramedullary monocytopoiesis. J Exp Med. 2012 Jan 16; 209(1):123-37. PMID: 22213805.
    Citations: 204     Fields:    Translation:AnimalsCells
  138. Robbins CS, Chudnovskiy A, Rauch PJ, Figueiredo JL, Iwamoto Y, Gorbatov R, Etzrodt M, Weber GF, Ueno T, van Rooijen N, Mulligan-Kehoe MJ, Libby P, Nahrendorf M, Pittet MJ, Weissleder R, Swirski FK. Extramedullary hematopoiesis generates Ly-6C(high) monocytes that infiltrate atherosclerotic lesions. Circulation. 2012 Jan 17; 125(2):364-74. PMID: 22144566.
    Citations: 168     Fields:    Translation:AnimalsCells
  139. Leuschner F, Dutta P, Gorbatov R, Novobrantseva TI, Donahoe JS, Courties G, Lee KM, Kim JI, Markmann JF, Marinelli B, Panizzi P, Lee WW, Iwamoto Y, Milstein S, Epstein-Barash H, Cantley W, Wong J, Cortez-Retamozo V, Newton A, Love K, Libby P, Pittet MJ, Swirski FK, Koteliansky V, Langer R, Weissleder R, Anderson DG, Nahrendorf M. Therapeutic siRNA silencing in inflammatory monocytes in mice. Nat Biotechnol. 2011 Oct 09; 29(11):1005-10. PMID: 21983520.
    Citations: 277     Fields:    Translation:HumansAnimalsCells
  140. Settles M, Etzrodt M, Kosanke K, Schiemann M, Zimmermann A, Meier R, Braren R, Huber A, Rummeny EJ, Weissleder R, Swirski FK, Wildgruber M. Different capacity of monocyte subsets to phagocytose iron-oxide nanoparticles. PLoS One. 2011; 6(10):e25197. PMID: 21984904.
    Citations: 23     Fields:    Translation:HumansCells
  141. Pittet MJ, Swirski FK. Monocytes link atherosclerosis and cancer. Eur J Immunol. 2011 Sep; 41(9):2519-22. PMID: 21952809.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  142. Panizzi P, Nahrendorf M, Figueiredo JL, Panizzi J, Marinelli B, Iwamoto Y, Keliher E, Maddur AA, Waterman P, Kroh HK, Leuschner F, Aikawa E, Swirski FK, Pittet MJ, Hackeng TM, Fuentes-Prior P, Schneewind O, Bock PE, Weissleder R. In vivo detection of Staphylococcus aureus endocarditis by targeting pathogen-specific prothrombin activation. Nat Med. 2011 Aug 21; 17(9):1142-6. PMID: 21857652.
    Citations: 57     Fields:    Translation:AnimalsCells
  143. Swirski FK. The spatial and developmental relationships in the macrophage family. Arterioscler Thromb Vasc Biol. 2011 Jul; 31(7):1517-22.