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Susan Bonner-Weir, PH.D.


The Mechanisms of matrix Remodeling Around Duct Cells After Partial Pancreatectomy
Summer, 06/25/01 - 08/17/01

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01DK110390 (BONNER-WEIR, SUSAN) Apr 1, 2017 - Mar 31, 2021
    Aging of the beta cell and type 2 diabetes
    Role: Principal Investigator
  2. R01DK093909 (BONNER-WEIR, SUSAN) Sep 20, 2011 - Jul 31, 2016
    Physiological Factors Driving Maturation of Neonatal Beta Cells
    Role: Principal Investigator
  3. S10RR025065 (BONNER-WEIR, SUSAN) May 1, 2009 - Apr 30, 2010
    Zeiss Laser Scan Microscope (LSM) 510-duo
    Role: Principal Investigator
  4. R01DK074879 (BONNER-WEIR, SUSAN) May 15, 2006 - Apr 30, 2009
    Strategies to Identify In Vitro Islet Progenitors
    Role: Principal Investigator
  5. R01DK066056 (BONNER-WEIR, SUSAN) Sep 15, 2005 - Jul 31, 2010
    Phenotypic Analysis of Young and Old Beta Cells
    Role: Principal Investigator
This researcher has shared information about their research resources in the eagle-i Network. To update or add resource records, contact eagle-i@hms.harvard.edu.
Advanced Microscopy Core (JDC) - Core services (5) and Instruments (3)

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Rezanejad H, Lock JH, Sullivan BA, Bonner-Weir S. Generation of Pancreatic Ductal Organoids and Whole-Mount Immunostaining of Intact Organoids. Curr Protoc Cell Biol. 2018 Dec 12; e82. PMID: 30548444.
    Citations:    Fields:    
  2. Aguayo-Mazzucato C, Lee TB, Matzko M, DiIenno A, Rezanejad H, Ramadoss P, Scanlan T, Zavacki AM, Larsen PR, Hollenberg A, Colton C, Sharma A, Bonner-Weir S. T3 Induces Both Markers of Maturation and Aging in Pancreatic ß-Cells. Diabetes. 2018 07; 67(7):1322-1331. PMID: 29625991.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  3. Loomans CJM, Williams Giuliani N, Balak J, Ringnalda F, van Gurp L, Huch M, Boj SF, Sato T, Kester L, de Sousa Lopes SMC, Roost MS, Bonner-Weir S, Engelse MA, Rabelink TJ, Heimberg H, Vries RGJ, van Oudenaarden A, Carlotti F, Clevers H, de Koning EJP. Expansion of Adult Human Pancreatic Tissue Yields Organoids Harboring Progenitor Cells with Endocrine Differentiation Potential. Stem Cell Reports. 2018 03 13; 10(3):712-724. PMID: 29539434.
    Citations: 2     Fields:    
  4. Rezanejad H, Ouziel-Yahalom L, Keyzer CA, Sullivan BA, Hollister-Lock J, Li WC, Guo L, Deng S, Lei J, Markmann J, Bonner-Weir S. Heterogeneity of SOX9 and HNF1ß in Pancreatic Ducts Is Dynamic. Stem Cell Reports. 2018 03 13; 10(3):725-738. PMID: 29478894.
    Citations:    Fields:    
  5. Aguayo-Mazzucato C, Bonner-Weir S. Pancreatic ß Cell Regeneration as a Possible Therapy for Diabetes. Cell Metab. 2018 Jan 09; 27(1):57-67. PMID: 28889951.
    Citations: 2     Fields:    
  6. Aguayo-Mazzucato C, van Haaren M, Mruk M, Lee TB, Crawford C, Hollister-Lock J, Sullivan BA, Johnson JW, Ebrahimi A, Dreyfuss JM, Van Deursen J, Weir GC, Bonner-Weir S. ß Cell Aging Markers Have Heterogeneous Distribution and Are Induced by Insulin Resistance. Cell Metab. 2017 Apr 04; 25(4):898-910.e5. PMID: 28380379.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  7. Ebrahimi A, Jung MH, Dreyfuss JM, Pan H, Sgroi D, Bonner-Weir S, Weir GC. Evidence of stress in ß cells obtained with laser capture microdissection from pancreases of brain dead donors. Islets. 2017 03 04; 9(2):19-29. PMID: 28252345.
    Citations: 1     Fields:    Translation:HumansCells
  8. Weir GC, Bonner-Weir S. Glucose Driven Changes in Beta Cell Identity Are Important for Function and Possibly Autoimmune Vulnerability during the Progression of Type 1 Diabetes. Front Genet. 2017; 8:2. PMID: 28174593.
    Citations: 1     
  9. Weir GC, Bonner-Weir S. GABA Signaling Stimulates ß Cell Regeneration in Diabetic Mice. Cell. 2017 01 12; 168(1-2):7-9. PMID: 28086099.
    Citations: 1     Fields:    Translation:AnimalsCells
  10. Bonner-Weir S, Aguayo-Mazzucato C. Physiology: Pancreatic ß-cell heterogeneity revisited. Nature. 2016 07 21; 535(7612):365-6. PMID: 27398615.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  11. Corritore E, Lee YS, Pasquale V, Liberati D, Hsu MJ, Lombard CA, Van Der Smissen P, Vetere A, Bonner-Weir S, Piemonti L, Sokal E, Lysy PA. V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog A Synthetic Modified mRNA Drives Reprogramming of Human Pancreatic Duct-Derived Cells Into Insulin-Secreting Cells. Stem Cells Transl Med. 2016 Nov; 5(11):1525-1537. PMID: 27405779.
    Citations: 1     Fields:    
  12. Bonner-Weir S, Aguayo-Mazzucato C, Weir GC. Dynamic development of the pancreas from birth to adulthood. Ups J Med Sci. 2016 May; 121(2):155-8. PMID: 26998806.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  13. Kuznetsova A, Yu Y, Hollister-Lock J, Opare-Addo L, Rozzo A, Sadagurski M, Norquay L, Reed JE, El Khattabi I, Bonner-Weir S, Weir GC, Sharma A, White MF. Trimeprazine increases IRS2 in human islets and promotes pancreatic ß cell growth and function in mice. JCI Insight. 2016; 1(3). PMID: 27152363.
    Citations: 1     Fields:    
  14. Cavelti-Weder C, Li W, Zumsteg A, Stemann-Andersen M, Zhang Y, Yamada T, Wang M, Lu J, Jermendy A, Bee YM, Bonner-Weir S, Weir GC, Zhou Q. Hyperglycaemia attenuates in vivo reprogramming of pancreatic exocrine cells to beta cells in mice. Diabetologia. 2016 Mar; 59(3):522-32. PMID: 26693711; PMCID: PMC4744133.
    Citations: 8     Fields:    Translation:AnimalsCells
  15. Nishimura W, Kapoor A, El Khattabi I, Jin W, Yasuda K, Bonner-Weir S, Sharma A. Compensatory Response by Late Embryonic Tubular Epithelium to the Reduction in Pancreatic Progenitors. PLoS One. 2015; 10(11):e0142286. PMID: 26540252; PMCID: PMC4635002.
    Citations:    Fields:    Translation:AnimalsCells
  16. Aguayo-Mazzucato C, DiIenno A, Hollister-Lock J, Cahill C, Sharma A, Weir G, Colton C, Bonner-Weir S. MAFA and T3 Drive Maturation of Both Fetal Human Islets and Insulin-Producing Cells Differentiated From hESC. J Clin Endocrinol Metab. 2015 Oct; 100(10):3651-9. PMID: 26207953; PMCID: PMC4596039.
    Citations: 6     Fields:    Translation:HumansCells
  17. Yamada T, Cavelti-Weder C, Caballero F, Lysy PA, Guo L, Sharma A, Li W, Zhou Q, Bonner-Weir S, Weir GC. Reprogramming Mouse Cells With a Pancreatic Duct Phenotype to Insulin-Producing ß-Like Cells. Endocrinology. 2015 Jun; 156(6):2029-38. PMID: 25836667; PMCID: PMC4430605.
    Citations: 8     Fields:    Translation:AnimalsCells
  18. Cavelti-Weder C, Li W, Zumsteg A, Stemann M, Yamada T, Bonner-Weir S, Weir G, Zhou Q. Direct Reprogramming for Pancreatic Beta-Cells Using Key Developmental Genes. Curr Pathobiol Rep. 2015 Mar 01; 3(1):57-65. PMID: 26998407.
  19. Bonner-Weir S, Sullivan BA, Weir GC. Human Islet Morphology Revisited: Human and Rodent Islets Are Not So Different After All. J Histochem Cytochem. 2015 08; 63(8):604-12. PMID: 25604813; PMCID: PMC4530393.
    Citations: 17     Fields:    Translation:HumansAnimals
  20. Sullivan BA, Hollister-Lock J, Bonner-Weir S, Weir GC. Reduced Ki67 Staining in the Postmortem State Calls Into Question Past Conclusions About the Lack of Turnover of Adult Human ß-Cells. Diabetes. 2015 May; 64(5):1698-702. PMID: 25488899; PMCID: PMC4407864.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  21. Corritore E, Dugnani E, Pasquale V, Misawa R, Witkowski P, Lei J, Markmann J, Piemonti L, Sokal EM, Bonner-Weir S, Lysy PA. ß-Cell differentiation of human pancreatic duct-derived cells after in vitro expansion. Cell Reprogram. 2014 Dec; 16(6):456-66. PMID: 25437872.
    Citations: 8     Fields:    Translation:HumansCells
  22. Gusarova V, Alexa CA, Na E, Stevis PE, Xin Y, Bonner-Weir S, Cohen JC, Hobbs HH, Murphy AJ, Yancopoulos GD, Gromada J. ANGPTL8/betatrophin does not control pancreatic beta cell expansion. Cell. 2014 Oct 23; 159(3):691-6. PMID: 25417115; PMCID: PMC4243040.
    Citations: 58     Fields:    Translation:AnimalsCells
  23. Bonner-Weir S, In't Veld PA, Weir GC. Reanalysis of study of pancreatic effects of incretin therapy: methodological deficiencies. Diabetes Obes Metab. 2014 Jul; 16(7):661-6. PMID: 24400596.
    Citations: 17     Fields:    Translation:HumansCells
  24. Weir GC, Aguayo-Mazzucato C, Bonner-Weir S. ß-cell dedifferentiation in diabetes is important, but what is it? Islets. 2013 Sep-Dec; 5(5):233-7. PMID: 24356710.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  25. Chadwick KD, Fletcher AM, Parrula MC, Bonner-Weir S, Mangipudy RS, Janovitz E, Graziano MJ, Roy D, Reilly TP. Occurrence of spontaneous pancreatic lesions in normal and diabetic rats: a potential confounding factor in the nonclinical assessment of GLP-1-based therapies. Diabetes. 2014 Apr; 63(4):1303-14. PMID: 24222349.
    Citations: 8     Fields:    Translation:Animals
  26. He KH, Juhl K, Karadimos M, El Khattabi I, Fitzpatrick C, Bonner-Weir S, Sharma A. Differentiation of pancreatic endocrine progenitors reversibly blocked by premature induction of MafA. Dev Biol. 2014 Jan 01; 385(1):2-12. PMID: 24183936.
    Citations: 8     Fields:    Translation:AnimalsCells
  27. King AJ, Guo Y, Cai D, Hollister-Lock J, Morris B, Salvatori A, Corbett JA, Bonner-Weir S, Shoelson SE, Weir GC. Sustained NF-?B activation and inhibition in ß-cells have minimal effects on function and islet transplant outcomes. PLoS One. 2013; 8(10):e77452. PMID: 24204831; PMCID: PMC3799630.
    Citations: 1     Fields:    Translation:AnimalsCells
  28. Lysy PA, Weir GC, Bonner-Weir S. Making ß cells from adult cells within the pancreas. Curr Diab Rep. 2013 Oct; 13(5):695-703. PMID: 23925431; PMCID: PMC3798031.
    Citations: 11     Fields:    Translation:HumansCells
  29. Cavelti-Weder C, Shtessel M, Reuss JE, Jermendy A, Yamada T, Caballero F, Bonner-Weir S, Weir GC. Pancreatic duct ligation after almost complete ß-cell loss: exocrine regeneration but no evidence of ß-cell regeneration. Endocrinology. 2013 Dec; 154(12):4493-502. PMID: 24029238; PMCID: PMC3836076.
    Citations: 14     Fields:    Translation:AnimalsCells
  30. Wu F, Guo L, Jakubowski A, Su L, Li WC, Bonner-Weir S, Burkly LC. TNF-like weak inducer of apoptosis (TWEAK) promotes beta cell neogenesis from pancreatic ductal epithelium in adult mice. PLoS One. 2013; 8(8):e72132. PMID: 23991053; PMCID: PMC3753348.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  31. Guo L, Inada A, Aguayo-Mazzucato C, Hollister-Lock J, Fujitani Y, Weir GC, Wright CV, Sharma A, Bonner-Weir S. PDX1 in ducts is not required for postnatal formation of ß-cells but is necessary for their subsequent maturation. Diabetes. 2013 Oct; 62(10):3459-68. PMID: 23775765.
    Citations: 6     Fields:    Translation:AnimalsCells
  32. Spijker HS, Ravelli RB, Mommaas-Kienhuis AM, van Apeldoorn AA, Engelse MA, Zaldumbide A, Bonner-Weir S, Rabelink TJ, Hoeben RC, Clevers H, Mummery CL, Carlotti F, de Koning EJ. Conversion of mature human ß-cells into glucagon-producing a-cells. Diabetes. 2013 Jul; 62(7):2471-80. PMID: 23569174; PMCID: PMC3712074.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  33. Weir GC, Bonner-Weir S. Islet ß cell mass in diabetes and how it relates to function, birth, and death. Ann N Y Acad Sci. 2013 Apr; 1281:92-105. PMID: 23363033; PMCID: PMC3618572.
    Citations: 67     Fields:    Translation:HumansAnimalsCells
  34. Aguayo-Mazzucato C, Zavacki AM, Marinelarena A, Hollister-Lock J, El Khattabi I, Marsili A, Weir GC, Sharma A, Larsen PR, Bonner-Weir S. Thyroid hormone promotes postnatal rat pancreatic ß-cell development and glucose-responsive insulin secretion through MAFA. Diabetes. 2013 May; 62(5):1569-80. PMID: 23305647.
    Citations: 31     Fields:    Translation:AnimalsCells
  35. Caballero F, Siniakowicz K, Hollister-Lock J, Duran L, Katsuta H, Yamada T, Lei J, Deng S, Westermark GT, Markmann J, Bonner-Weir S, Weir GC. Birth and death of human ß-cells in pancreases from cadaver donors, autopsies, surgical specimens, and islets transplanted into mice. Cell Transplant. 2014 Feb; 23(2):139-51. PMID: 23321263; PMCID: PMC3947859.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  36. Bonner-Weir S, Guo L, Li WC, Ouziel-Yahalom L, Lysy PA, Weir GC, Sharma A. Islet neogenesis: a possible pathway for beta-cell replenishment. Rev Diabet Stud. 2012; 9(4):407-16. PMID: 23804276.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  37. Katsuta H, Aguayo-Mazzucato C, Katsuta R, Akashi T, Hollister-Lock J, Sharma AJ, Bonner-Weir S, Weir GC. Subpopulations of GFP-marked mouse pancreatic ß-cells differ in size, granularity, and insulin secretion. Endocrinology. 2012 Nov; 153(11):5180-7. PMID: 22919061.
    Citations: 13     Fields:    Translation:AnimalsCells
  38. Sarruf DA, Bonner-Weir S, Schwartz MW. New clues to bariatric surgery's benefits. Nat Med. 2012 Jun 06; 18(6):860-1. PMID: 22673995; PMCID: PMC3600352.
    Citations: 3     Fields:    Translation:HumansAnimals
  39. Lysy PA, Weir GC, Bonner-Weir S. Concise review: pancreas regeneration: recent advances and perspectives. Stem Cells Transl Med. 2012 Feb; 1(2):150-9. PMID: 23197762; PMCID: PMC3659687.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  40. Weir GC, Cavelti-Weder C, Bonner-Weir S. Stem cell approaches for diabetes: towards beta cell replacement. Genome Med. 2011 Sep 27; 3(9):61. PMID: 21951399; PMCID: PMC3239236.
    Citations: 21     Fields:    
  41. Weir GC, Bonner-Weir S. Finally! A human pancreatic ß cell line. J Clin Invest. 2011 Sep; 121(9):3395-7. PMID: 21865653.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  42. Weir GC, Bonner-Weir S. Sleeping islets and the relationship between ß-cell mass and function. Diabetes. 2011 Aug; 60(8):2018-9. PMID: 21788579; PMCID: PMC3142069.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  43. Marsili A, Aguayo-Mazzucato C, Chen T, Kumar A, Chung M, Lunsford EP, Harney JW, Van-Tran T, Gianetti E, Ramadan W, Chou C, Bonner-Weir S, Larsen PR, Silva JE, Zavacki AM. Mice with a targeted deletion of the type 2 deiodinase are insulin resistant and susceptible to diet induced obesity. PLoS One. 2011; 6(6):e20832. PMID: 21698184; PMCID: PMC3116839.
    Citations: 33     Fields:    Translation:Animals
  44. Johnson AS, O'Sullivan E, D'Aoust LN, Omer A, Bonner-Weir S, Fisher RJ, Weir GC, Colton CK. Quantitative assessment of islets of Langerhans encapsulated in alginate. Tissue Eng Part C Methods. 2011 Apr; 17(4):435-49. PMID: 21067465; PMCID: PMC3065730.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  45. Jermendy A, Toschi E, Aye T, Koh A, Aguayo-Mazzucato C, Sharma A, Weir GC, Sgroi D, Bonner-Weir S. Rat neonatal beta cells lack the specialised metabolic phenotype of mature beta cells. Diabetologia. 2011 Mar; 54(3):594-604. PMID: 21240476; PMCID: PMC3045081.
    Citations: 22     Fields:    Translation:AnimalsCells
  46. Aguayo-Mazzucato C, Koh A, El Khattabi I, Li WC, Toschi E, Jermendy A, Juhl K, Mao K, Weir GC, Sharma A, Bonner-Weir S. Mafa expression enhances glucose-responsive insulin secretion in neonatal rat beta cells. Diabetologia. 2011 Mar; 54(3):583-93. PMID: 21190012; PMCID: PMC3047400.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  47. Thorrez L, Laudadio I, Van Deun K, Quintens R, Hendrickx N, Granvik M, Lemaire K, Schraenen A, Van Lommel L, Lehnert S, Aguayo-Mazzucato C, Cheng-Xue R, Gilon P, Van Mechelen I, Bonner-Weir S, Lemaigre F, Schuit F. Tissue-specific disallowance of housekeeping genes: the other face of cell differentiation. Genome Res. 2011 Jan; 21(1):95-105. PMID: 21088282; PMCID: PMC3012930.
    Citations: 49     Fields:    Translation:Animals
  48. Bonner-Weir S, Li WC, Ouziel-Yahalom L, Guo L, Weir GC, Sharma A. Beta-cell growth and regeneration: replication is only part of the story. Diabetes. 2010 Oct; 59(10):2340-8. PMID: 20876724; PMCID: PMC3279552.
    Citations: 90     Fields:    Translation:HumansAnimalsCells
  49. Hamamoto Y, Akashi T, Inada A, Bonner-Weir S, Weir GC. Lack of evidence for recipient precursor cells replenishing ß-cells in transplanted islets. Cell Transplant. 2010; 19(12):1563-72. PMID: 20719077.
    Citations: 3     Fields:    Translation:AnimalsCells
  50. Keenan HA, Sun JK, Levine J, Doria A, Aiello LP, Eisenbarth G, Bonner-Weir S, King GL. Residual insulin production and pancreatic ß-cell turnover after 50 years of diabetes: Joslin Medalist Study. Diabetes. 2010 Nov; 59(11):2846-53. PMID: 20699420; PMCID: PMC2963543.
    Citations: 115     Fields:    Translation:HumansCells
  51. Pisania A, Papas KK, Powers DE, Rappel MJ, Omer A, Bonner-Weir S, Weir GC, Colton CK. Enumeration of islets by nuclei counting and light microscopic analysis. Lab Invest. 2010 Nov; 90(11):1676-86. PMID: 20697375; PMCID: PMC2966546.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  52. Pisania A, Weir GC, O'Neil JJ, Omer A, Tchipashvili V, Lei J, Colton CK, Bonner-Weir S. Quantitative analysis of cell composition and purity of human pancreatic islet preparations. Lab Invest. 2010 Nov; 90(11):1661-75. PMID: 20697378; PMCID: PMC2966538.
    Citations: 32     Fields:    Translation:Humans
  53. Li WC, Rukstalis JM, Nishimura W, Tchipashvili V, Habener JF, Sharma A, Bonner-Weir S. Activation of pancreatic-duct-derived progenitor cells during pancreas regeneration in adult rats. J Cell Sci. 2010 Aug 15; 123(Pt 16):2792-802. PMID: 20663919; PMCID: PMC2915881.
    Citations: 52     Fields:    Translation:AnimalsCells
  54. Marselli L, Thorne J, Dahiya S, Sgroi DC, Sharma A, Bonner-Weir S, Marchetti P, Weir GC. Gene expression profiles of Beta-cell enriched tissue obtained by laser capture microdissection from subjects with type 2 diabetes. PLoS One. 2010 Jul 13; 5(7):e11499. PMID: 20644627; PMCID: PMC2903480.
    Citations: 75     Fields:    Translation:HumansCells
  55. Weir GC, Bonner-Weir S. Dreams for type 1 diabetes: shutting off autoimmunity and stimulating beta-cell regeneration. Endocrinology. 2010 Jul; 151(7):2971-3. PMID: 20570953.
    Citations: 3     Fields:    Translation:AnimalsCells
  56. Kennedy J, Katsuta H, Jung MH, Marselli L, Goldfine AB, Balis UJ, Sgroi D, Bonner-Weir S, Weir GC. Protective unfolded protein response in human pancreatic beta cells transplanted into mice. PLoS One. 2010 Jun 18; 5(6):e11211. PMID: 20585452; PMCID: PMC2887848.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  57. Powers DE, Millman JR, Bonner-Weir S, Rappel MJ, Colton CK. Accurate control of oxygen level in cells during culture on silicone rubber membranes with application to stem cell differentiation. Biotechnol Prog. 2010 May-Jun; 26(3):805-18. PMID: 20039374.
    Citations: 3     Fields:    Translation:AnimalsCells
  58. Aguayo-Mazzucato C, Bonner-Weir S. Stem cell therapy for type 1 diabetes mellitus. Nat Rev Endocrinol. 2010 Mar; 6(3):139-48. PMID: 20173775.
    Citations: 41     Fields:    Translation:HumansCells
  59. Juhl K, Bonner-Weir S, Sharma A. Regenerating pancreatic beta-cells: plasticity of adult pancreatic cells and the feasibility of in-vivo neogenesis. Curr Opin Organ Transplant. 2010 Feb; 15(1):79-85. PMID: 19907327; PMCID: PMC2834213.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  60. O'Sullivan ES, Johnson AS, Omer A, Hollister-Lock J, Bonner-Weir S, Colton CK, Weir GC. Rat islet cell aggregates are superior to islets for transplantation in microcapsules. Diabetologia. 2010 May; 53(5):937-945. PMID: 20101386; PMCID: PMC4327903.
    Citations: 23     Fields:    Translation:AnimalsCells
  61. Gianani R, Campbell-Thompson M, Sarkar SA, Wasserfall C, Pugliese A, Solis JM, Kent SC, Hering BJ, West E, Steck A, Bonner-Weir S, Atkinson MA, Coppieters K, von Herrath M, Eisenbarth GS. Dimorphic histopathology of long-standing childhood-onset diabetes. Diabetologia. 2010 Apr; 53(4):690-8. PMID: 20062967.
    Citations: 68     Fields:    Translation:HumansCells
  62. Aye T, Toschi E, Sharma A, Sgroi D, Bonner-Weir S. Identification of markers for newly formed beta-cells in the perinatal period: a time of recognized beta-cell immaturity. J Histochem Cytochem. 2010 Apr; 58(4):369-76. PMID: 20051380; PMCID: PMC2842599.
    Citations: 16     Fields:    Translation:AnimalsCells
  63. Kushner JA, Weir GC, Bonner-Weir S. Ductal origin hypothesis of pancreatic regeneration under attack. Cell Metab. 2010 Jan; 11(1):2-3. PMID: 20085728; PMCID: PMC3762572.
    Citations: 36     Fields:    Translation:AnimalsCells
  64. Weir GC, Marselli L, Marchetti P, Katsuta H, Jung MH, Bonner-Weir S. Towards better understanding of the contributions of overwork and glucotoxicity to the beta-cell inadequacy of type 2 diabetes. Diabetes Obes Metab. 2009 Nov; 11 Suppl 4:82-90. PMID: 19817791.
    Citations: 29     Fields:    Translation:HumansCells
  65. Vetere A, Li WC, Paroni F, Juhl K, Guo L, Nishimura W, Dai X, Bonner-Weir S, Sharma A. OVO homologue-like 1 (Ovol1) transcription factor: a novel target of neurogenin-3 in rodent pancreas. Diabetologia. 2010 Jan; 53(1):115-22. PMID: 19882138; PMCID: PMC3066144.
    Citations:    Fields:    Translation:AnimalsCells
  66. Katsuta H, Akashi T, Katsuta R, Nagaya M, Kim D, Arinobu Y, Hara M, Bonner-Weir S, Sharma AJ, Akashi K, Weir GC. Single pancreatic beta cells co-express multiple islet hormone genes in mice. Diabetologia. 2010 Jan; 53(1):128-38. PMID: 19851748.
    Citations: 27     Fields:    Translation:AnimalsCells
  67. Borowiec M, Liew CW, Thompson R, Boonyasrisawat W, Hu J, Mlynarski WM, El Khattabi I, Kim SH, Marselli L, Rich SS, Krolewski AS, Bonner-Weir S, Sharma A, Sale M, Mychaleckyj JC, Kulkarni RN, Doria A. Mutations at the BLK locus linked to maturity onset diabetes of the young and beta-cell dysfunction. Proc Natl Acad Sci U S A. 2009 Aug 25; 106(34):14460-5. PMID: 19667185.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  68. Nishimura W, Bonner-Weir S, Sharma A. Expression of MafA in pancreatic progenitors is detrimental for pancreatic development. Dev Biol. 2009 Sep 01; 333(1):108-20. PMID: 19576197; PMCID: PMC2737322.
    Citations: 12     Fields:    Translation:AnimalsCells
  69. Kondo T, El Khattabi I, Nishimura W, Laybutt DR, Geraldes P, Shah S, King G, Bonner-Weir S, Weir G, Sharma A. p38 MAPK is a major regulator of MafA protein stability under oxidative stress. Mol Endocrinol. 2009 Aug; 23(8):1281-90. PMID: 19407223; PMCID: PMC2718751.
    Citations: 11     Fields:    Translation:AnimalsCells
  70. Kikugawa R, Katsuta H, Akashi T, Yatoh S, Weir GC, Sharma A, Bonner-Weir S. Differentiation of COPAS-sorted non-endocrine pancreatic cells into insulin-positive cells in the mouse. Diabetologia. 2009 Apr; 52(4):645-52. PMID: 19183938; PMCID: PMC4336153.
    Citations: 8     Fields:    Translation:AnimalsCells
  71. Nagaya M, Katsuta H, Kaneto H, Bonner-Weir S, Weir GC. Adult mouse intrahepatic biliary epithelial cells induced in vitro to become insulin-producing cells. J Endocrinol. 2009 Apr; 201(1):37-47. PMID: 19168505.
    Citations: 26     Fields:    Translation:AnimalsCells
  72. Emamaullee JA, Merani S, Toso C, Kin T, Al-Saif F, Truong W, Pawlick R, Davis J, Edgar R, Lock J, Bonner-Weir S, Knudsen LB, Shapiro AM. Porcine marginal mass islet autografts resist metabolic failure over time and are enhanced by early treatment with liraglutide. Endocrinology. 2009 May; 150(5):2145-52. PMID: 19131571.
    Citations: 11     Fields:    Translation:AnimalsCells
  73. Marselli L, Sgroi DC, Bonner-Weir S, Weir GC. Laser capture microdissection of human pancreatic beta-cells and RNA preparation for gene expression profiling. Methods Mol Biol. 2009; 560:87-98. PMID: 19504246.
    Citations: 13     Fields:    Translation:HumansCells
  74. Inada A, Nienaber C, Katsuta H, Fujitani Y, Levine J, Morita R, Sharma A, Bonner-Weir S. Carbonic anhydrase II-positive pancreatic cells are progenitors for both endocrine and exocrine pancreas after birth. Proc Natl Acad Sci U S A. 2008 Dec 16; 105(50):19915-9. PMID: 19052237; PMCID: PMC2604974.
    Citations: 172     Fields:    Translation:HumansAnimalsCells
  75. Dodge R, Loomans C, Sharma A, Bonner-Weir S. Developmental pathways during in vitro progression of human islet neogenesis. Differentiation. 2009 Feb; 77(2):135-47. PMID: 19281773; PMCID: PMC2766238.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  76. Bonner-Weir S, O'Brien TD. Islets in type 2 diabetes: in honor of Dr. Robert C. Turner. Diabetes. 2008 Nov; 57(11):2899-904. PMID: 18971437; PMCID: PMC2570382.
    Citations: 19     Fields:    Translation:Humans
  77. Koulmanda M, Bhasin M, Hoffman L, Fan Z, Qipo A, Shi H, Bonner-Weir S, Putheti P, Degauque N, Libermann TA, Auchincloss H, Flier JS, Strom TB. Curative and beta cell regenerative effects of alpha1-antitrypsin treatment in autoimmune diabetic NOD mice. Proc Natl Acad Sci U S A. 2008 Oct 21; 105(42):16242-7. PMID: 18852471; PMCID: PMC2570971.
    Citations: 67     Fields:    Translation:AnimalsCells
  78. Akashi T, Shigematsu H, Hamamoto Y, Iwasaki H, Yatoh S, Bonner-Weir S, Akashi K, Weir GC. Bone marrow or foetal liver cells fail to induce islet regeneration in diabetic Akita mice. Diabetes Metab Res Rev. 2008 Oct; 24(7):585-90. PMID: 18727153.
    Citations: 2     Fields:    Translation:Animals
  79. Larade K, Jiang Z, Zhang Y, Wang W, Bonner-Weir S, Zhu H, Bunn HF. Loss of Ncb5or results in impaired fatty acid desaturation, lipoatrophy, and diabetes. J Biol Chem. 2008 Oct 24; 283(43):29285-91. PMID: 18682384; PMCID: PMC2570878.
    Citations: 15     Fields:    Translation:AnimalsCells
  80. Bonner-Weir S, Inada A, Yatoh S, Li WC, Aye T, Toschi E, Sharma A. Transdifferentiation of pancreatic ductal cells to endocrine beta-cells. Biochem Soc Trans. 2008 Jun; 36(Pt 3):353-6. PMID: 18481956.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  81. de Koning EJ, Bonner-Weir S, Rabelink TJ. Preservation of beta-cell function by targeting beta-cell mass. Trends Pharmacol Sci. 2008 Apr; 29(4):218-27. PMID: 18359095.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  82. Nishimura W, Rowan S, Salameh T, Maas RL, Bonner-Weir S, Sell SM, Sharma A. Preferential reduction of beta cells derived from Pax6-MafB pathway in MafB deficient mice. Dev Biol. 2008 Feb 15; 314(2):443-56. PMID: 18199433; PMCID: PMC2435621.
    Citations: 21     Fields:    Translation:AnimalsCells
  83. Marselli L, Thorne J, Ahn YB, Omer A, Sgroi DC, Libermann T, Otu HH, Sharma A, Bonner-Weir S, Weir GC. Gene expression of purified beta-cell tissue obtained from human pancreas with laser capture microdissection. J Clin Endocrinol Metab. 2008 Mar; 93(3):1046-53. PMID: 18073315; PMCID: PMC2266961.
    Citations: 33     Fields:    Translation:HumansCells
  84. Koulmanda M, Budo E, Bonner-Weir S, Qipo A, Putheti P, Degauque N, Shi H, Fan Z, Flier JS, Auchincloss H, Zheng XX, Strom TB. Modification of adverse inflammation is required to cure new-onset type 1 diabetic hosts. Proc Natl Acad Sci U S A. 2007 Aug 07; 104(32):13074-9. PMID: 17670937; PMCID: PMC1941818.
    Citations: 33     Fields:    Translation:AnimalsCells
  85. Laybutt DR, Hawkins YC, Lock J, Lebet J, Sharma A, Bonner-Weir S, Weir GC. Influence of diabetes on the loss of beta cell differentiation after islet transplantation in rats. Diabetologia. 2007 Oct; 50(10):2117-25. PMID: 17641871.
    Citations: 17     Fields:    Translation:AnimalsCells
  86. King AJ, Fernandes JR, Hollister-Lock J, Nienaber CE, Bonner-Weir S, Weir GC. Normal relationship of beta- and non-beta-cells not needed for successful islet transplantation. Diabetes. 2007 Sep; 56(9):2312-8. PMID: 17563059.
    Citations: 17     Fields:    Translation:AnimalsCells
  87. Xue B, Kim YB, Lee A, Toschi E, Bonner-Weir S, Kahn CR, Neel BG, Kahn BB. Protein-tyrosine phosphatase 1B deficiency reduces insulin resistance and the diabetic phenotype in mice with polygenic insulin resistance. J Biol Chem. 2007 Aug 17; 282(33):23829-40. PMID: 17545163.
    Citations: 20     Fields:    Translation:AnimalsCells
  88. Yatoh S, Dodge R, Akashi T, Omer A, Sharma A, Weir GC, Bonner-Weir S. Differentiation of affinity-purified human pancreatic duct cells to beta-cells. Diabetes. 2007 Jul; 56(7):1802-9. PMID: 17473224.
    Citations: 51     Fields:    Translation:HumansCells
  89. Xu G, Kaneto H, Laybutt DR, Duvivier-Kali VF, Trivedi N, Suzuma K, King GL, Weir GC, Bonner-Weir S. Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: possible contribution to impaired incretin effects in diabetes. Diabetes. 2007 Jun; 56(6):1551-8. PMID: 17360984.
    Citations: 75     Fields:    Translation:AnimalsCells
  90. Yatoh S, Akashi T, Chan PP, Kaneto H, Sharma A, Bonner-Weir S, Weir GC. NeuroD and reaggregation induce beta-cell specific gene expression in cultured hepatocytes. Diabetes Metab Res Rev. 2007 Mar; 23(3):239-49. PMID: 16921545.
    Citations: 7     Fields:    Translation:AnimalsCells
  91. Weir GC, Bonner-Weir S. A dominant role for glucose in beta cell compensation of insulin resistance. J Clin Invest. 2007 Jan; 117(1):81-3. PMID: 17200709; PMCID: PMC1716221.
    Citations: 21     Fields:    Translation:HumansCells
  92. Ahn YB, Xu G, Marselli L, Toschi E, Sharma A, Bonner-Weir S, Sgroi DC, Weir GC. Changes in gene expression in beta cells after islet isolation and transplantation using laser-capture microdissection. Diabetologia. 2007 Feb; 50(2):334-42. PMID: 17180350.
    Citations: 19     Fields:    Translation:AnimalsCells
  93. Krishnamurthy J, Ramsey MR, Ligon KL, Torrice C, Koh A, Bonner-Weir S, Sharpless NE. p16INK4a induces an age-dependent decline in islet regenerative potential. Nature. 2006 Sep 28; 443(7110):453-7. PMID: 16957737.
    Citations: 317     Fields:    Translation:Animals
  94. Evgenov NV, Medarova Z, Pratt J, Pantazopoulos P, Leyting S, Bonner-Weir S, Moore A. In vivo imaging of immune rejection in transplanted pancreatic islets. Diabetes. 2006 Sep; 55(9):2419-28. PMID: 16936189.
    Citations: 50     Fields:    Translation:HumansAnimals
  95. Inada A, Nienaber C, Fonseca S, Bonner-Weir S. Timing and expression pattern of carbonic anhydrase II in pancreas. Dev Dyn. 2006 Jun; 235(6):1571-7. PMID: 16586439.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  96. Bonner-Weir S, Sharma A. Are there pancreatic progenitor cells from which new islets form after birth? Nat Clin Pract Endocrinol Metab. 2006 May; 2(5):240-1. PMID: 16932290.
    Citations: 18     Fields:    Translation:AnimalsCells
  97. López-Avalos MD, Duvivier-Kali VF, Xu G, Bonner-Weir S, Sharma A, Weir GC. Evidence for a role of the ubiquitin-proteasome pathway in pancreatic islets. Diabetes. 2006 May; 55(5):1223-31. PMID: 16644676.
    Citations: 17     Fields:    Translation:Cells
  98. Nishimura W, Kondo T, Salameh T, El Khattabi I, Dodge R, Bonner-Weir S, Sharma A. A switch from MafB to MafA expression accompanies differentiation to pancreatic beta-cells. Dev Biol. 2006 May 15; 293(2):526-39. PMID: 16580660; PMCID: PMC2390934.
    Citations: 104     Fields:    Translation:HumansAnimalsCells
  99. Inada A, Bonner-Weir S, Toschi E. How can we get more beta cells? Curr Diab Rep. 2006 Apr; 6(2):96-101. PMID: 16542618.
    Citations: 2     Fields:    Translation:HumansCells
  100. Inada A, Nienaber C, Bonner-Weir S. Endogenous beta-galactosidase expression in murine pancreatic islets. Diabetologia. 2006 May; 49(5):1120-2. PMID: 16541278.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  101. Xu G, Kaneto H, Lopez-Avalos MD, Weir GC, Bonner-Weir S. GLP-1/exendin-4 facilitates beta-cell neogenesis in rat and human pancreatic ducts. Diabetes Res Clin Pract. 2006 Jul; 73(1):107-10. PMID: 16406191.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  102. Medarova Z, Evgenov NV, Dai G, Bonner-Weir S, Moore A. In vivo multimodal imaging of transplanted pancreatic islets. Nat Protoc. 2006; 1(1):429-35. PMID: 17406265.
    Citations: 25     Fields:    Translation:HumansAnimals
  103. Noguchi H, Xu G, Matsumoto S, Kaneto H, Kobayashi N, Bonner-Weir S, Hayashi S. Induction of pancreatic stem/progenitor cells into insulin-producing cells by adenoviral-mediated gene transfer technology. Cell Transplant. 2006; 15(10):929-38. PMID: 17299998.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  104. Evgenov NV, Medarova Z, Dai G, Bonner-Weir S, Moore A. In vivo imaging of islet transplantation. Nat Med. 2006 Jan; 12(1):144-8. PMID: 16380717.
    Citations: 79     Fields:    Translation:HumansAnimals
  105. Noguchi H, Bonner-Weir S, Wei FY, Matsushita M, Matsumoto S. BETA2/NeuroD protein can be transduced into cells due to an arginine- and lysine-rich sequence. Diabetes. 2005 Oct; 54(10):2859-66. PMID: 16186386.