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Cynthia Lee Grosskreutz, M.D.,Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01EY013399 (MASLAND, RICHARD HARRY) Apr 1, 2001 - Mar 31, 2006
    NIH/NEI
    Neuroprotection and Retinal Ganglion Cell Death
    Role: Co-Principal Investigator
  2. K11EY000342 (GROSSKREUTZ, CYNTHIA L) Aug 1, 1994 - Jul 31, 2001
    NIH/NEI
    HYPOXIC REGULATION OF VASCULAR GROWTH IN VITRO
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Normand G, Maker M, Penraat J, Kovach K, Ghosh JG, Grosskreutz C, Chandra S. Non-invasive molecular tracking method that measures ocular drug distribution in non-human primates. Commun Biol. 2020 01 08; 3(1):16. PMID: 31925329.
    Citations:    
  2. Wang SV, Li N, Rice DS, Grosskreutz CL, Dryja TP, Prasanna G, Lii J, Gagne JJ. Using Healthcare Databases to Refine Understanding of Exploratory Associations Between Drugs and Progression of Open-Angle Glaucoma. Clin Pharmacol Ther. 2019 10; 106(4):874-883. PMID: 31038730.
    Citations:    
  3. Adams CM, Stacy R, Rangaswamy N, Bigelow C, Grosskreutz CL, Prasanna G. Glaucoma - Next Generation Therapeutics: Impossible to Possible. Pharm Res. 2018 Dec 13; 36(2):25. PMID: 30547244.
    Citations:    Fields:    Translation:HumansAnimals
  4. Stacy R, Huttner K, Watts J, Peace J, Wirta D, Walters T, Sall K, Seaman J, Ni X, Prasanna G, Mogi M, Adams C, Yan JH, Wald M, He Y, Newton R, Kolega R, Grosskreutz C. A Randomized, Controlled Phase I/II Study to Evaluate the Safety and Efficacy of MGV354 for Ocular Hypertension or Glaucoma. Am J Ophthalmol. 2018 08; 192:113-123. PMID: 29802818.
    Citations:    Fields:    
  5. Grosskreutz CL, Hockey HU, Serra D, Dryja TP. Dry Eye Signs and Symptoms Persist During Systemic Neutralization of IL-1ß by Canakinumab or IL-17A by Secukinumab. Cornea. 2015 Dec; 34(12):1551-6. PMID: 26418434.
    Citations: 1     Fields:    Translation:Humans
  6. Letko E, Yeh S, Foster CS, Pleyer U, Brigell M, Grosskreutz CL. Efficacy and safety of intravenous secukinumab in noninfectious uveitis requiring steroid-sparing immunosuppressive therapy. Ophthalmology. 2015 May; 122(5):939-48. PMID: 25638011.
    Citations: 12     Fields:    Translation:HumansCTClinical Trials
  7. Pasquale LR, Jiwani AZ, Zehavi-Dorin T, Majd A, Rhee DJ, Chen T, Turalba A, Shen L, Brauner S, Grosskreutz C, Gardiner M, Chen S, Borboli-Gerogiannis S, Greenstein SH, Chang K, Ritch R, Loomis S, Kang JH, Wiggs JL, Levkovitch-Verbin H. Solar exposure and residential geographic history in relation to exfoliation syndrome in the United States and Israel. JAMA Ophthalmol. 2014 Dec; 132(12):1439-45. PMID: 25188364.
    Citations: 8     Fields:    Translation:HumansPHPublic Health
  8. Wiggs JL, Pawlyk B, Connolly E, Adamian M, Miller JW, Pasquale LR, Haddadin RI, Grosskreutz CL, Rhee DJ, Li T. Disruption of the blood-aqueous barrier and lens abnormalities in mice lacking lysyl oxidase-like 1 (LOXL1). Invest Ophthalmol Vis Sci. 2014 Feb 10; 55(2):856-64. PMID: 24425853.
    Citations: 11     Fields:    Translation:Animals
  9. Qu J, Matsouaka R, Betensky RA, Hyman BT, Grosskreutz CL. Calcineurin activation causes retinal ganglion cell degeneration. Mol Vis. 2012; 18:2828-38. PMID: 23233785.
    Citations: 3     Fields:    Translation:AnimalsCells
  10. Pasquale LR, Loomis SJ, Kang JH, Yaspan BL, Abdrabou W, Budenz DL, Chen TC, Delbono E, Friedman DS, Gaasterland D, Gaasterland T, Grosskreutz CL, Lee RK, Lichter PR, Liu Y, McCarty CA, Moroi SE, Olson LM, Realini T, Rhee DJ, Schuman JS, Singh K, Vollrath D, Wollstein G, Zack DJ, Allingham RR, Pericak-Vance MA, Weinreb RN, Zhang K, Hauser MA, Richards JE, Haines JL, Wiggs JL. CDKN2B-AS1 genotype-glaucoma feature correlations in primary open-angle glaucoma patients from the United States. Am J Ophthalmol. 2013 Feb; 155(2):342-353.e5. PMID: 23111177.
    Citations: 19     Fields:    Translation:HumansCells
  11. Patel S, Takusagawa H, Shen L, Dohlman C, Grosskreutz C. Long-term complications associated with glaucoma drainage devices and Boston keratoprosthesis. Am J Ophthalmol. 2012 Jul; 154(1):207-8; author reply 208-9. PMID: 22709836.
    Citations: 3     Fields:    Translation:Humans
  12. Jiwani AZ, Rhee DJ, Brauner SC, Gardiner MF, Chen TC, Shen LQ, Chen SH, Grosskreutz CL, Chang KK, Kloek CE, Greenstein SH, Borboli-Gerogiannis S, Pasquale DL, Chaudhry S, Loomis S, Wiggs JL, Pasquale LR, Turalba AV. Effects of caffeinated coffee consumption on intraocular pressure, ocular perfusion pressure, and ocular pulse amplitude: a randomized controlled trial. Eye (Lond). 2012 Aug; 26(8):1122-30. PMID: 22678051.
    Citations: 7     Fields:    Translation:Humans
  13. Wu HY, Hudry E, Hashimoto T, Uemura K, Fan ZY, Berezovska O, Grosskreutz CL, Bacskai BJ, Hyman BT. Distinct dendritic spine and nuclear phases of calcineurin activation after exposure to amyloid-ß revealed by a novel fluorescence resonance energy transfer assay. J Neurosci. 2012 Apr 11; 32(15):5298-309. PMID: 22496575.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  14. Cade F, Grosskreutz CL, Tauber A, Dohlman CH. Glaucoma in eyes with severe chemical burn, before and after keratoprosthesis. Cornea. 2011 Dec; 30(12):1322-7. PMID: 22001817.
    Citations: 6     Fields:    Translation:Humans
  15. Qu J, Wang D, Grosskreutz CL. WITHDRAWN: Reprint of: Mechanisms of retinal ganglion cell injury and defense in glaucoma. Exp Eye Res. 2011 Jul 29. PMID: 21819981.
    Citations:    Fields:    
  16. Feke GT, Hazin R, Grosskreutz CL, Pasquale LR. Effect of brimonidine on retinal blood flow autoregulation in primary open-angle glaucoma. J Ocul Pharmacol Ther. 2011 Aug; 27(4):347-52. PMID: 21631365.
    Citations: 7     Fields:    Translation:Humans
  17. Turalba AV, Grosskreutz C. A review of current technology used in evaluating visual function in glaucoma. Semin Ophthalmol. 2010 Sep-Nov; 25(5-6):309-16. PMID: 21091017.
    Citations: 5     Fields:    Translation:Humans
  18. Fan BJ, Figuieredo Sena DR, Pasquale LR, Grosskreutz CL, Rhee DJ, Chen TC, Delbono EA, Haines JL, Wiggs JL. Lack of association of polymorphisms in elastin with pseudoexfoliation syndrome and glaucoma. J Glaucoma. 2010 Sep; 19(7):432-6. PMID: 20051886.
    Citations: 1     Fields:    Translation:Humans
  19. Qu J, Wang D, Grosskreutz CL. Mechanisms of retinal ganglion cell injury and defense in glaucoma. Exp Eye Res. 2010 Jul; 91(1):48-53. PMID: 20394744.
    Citations: 57     Fields:    Translation:HumansCells
  20. Wang DY, Ray A, Rodgers K, Ergorul C, Hyman BT, Huang W, Grosskreutz CL. Global gene expression changes in rat retinal ganglion cells in experimental glaucoma. Invest Ophthalmol Vis Sci. 2010 Aug; 51(8):4084-95. PMID: 20335623.
    Citations: 23     Fields:    Translation:AnimalsCells
  21. Ergorul C, Ray A, Huang W, Wang DY, Ben Y, Cantuti-Castelvetri I, Grosskreutz CL. Hypoxia inducible factor-1a (HIF-1a) and some HIF-1 target genes are elevated in experimental glaucoma. J Mol Neurosci. 2010 Oct; 42(2):183-91. PMID: 20237864.
    Citations: 8     Fields:    Translation:AnimalsCells
  22. Wang, D., Ray, A., Ergorul, C., Rodgers, K. and Grosskreutz, C.L. . Global Gene Expression Changes in Rat Retinal Ganglion Cells In Experimental Glaucoma. 2010; In Press.
  23. Wu HY, Hudry E, Hashimoto T, Kuchibhotla K, Rozkalne A, Fan Z, Spires-Jones T, Xie H, Arbel-Ornath M, Grosskreutz CL, Bacskai BJ, Hyman BT. Amyloid beta induces the morphological neurodegenerative triad of spine loss, dendritic simplification, and neuritic dystrophies through calcineurin activation. J Neurosci. 2010 Feb 17; 30(7):2636-49. PMID: 20164348.
    Citations: 147     Fields:    Translation:HumansAnimalsCells
  24. Dohlman CH, Grosskreutz CL, Chen TC, Pasquale LR, Rubin PA, Kim EC, Durand M. Shunts to divert aqueous humor to distant epithelialized cavities after keratoprosthesis surgery. J Glaucoma. 2010 Feb; 19(2):111-5. PMID: 19373101.
    Citations: 4     Fields:    Translation:Humans
  25. Huang W, Fileta J, Rawe I, Qu J, Grosskreutz CL. Calpain activation in experimental glaucoma. Invest Ophthalmol Vis Sci. 2010 Jun; 51(6):3049-54. PMID: 20107181.
    Citations: 24     Fields:    Translation:AnimalsCells
  26. Rivier D, Paula JS, Kim E, Dohlman CH, Grosskreutz CL. Glaucoma and keratoprosthesis surgery: role of adjunctive cyclophotocoagulation. J Glaucoma. 2009 Apr-May; 18(4):321-4. PMID: 19365199.
    Citations: 8     Fields:    Translation:Humans
  27. Filippopoulos T, Hanna E, Chen TC, Grosskreutz CL, Jakobiec FA, Pasquale LR. Correlation of filtration bleb morphology with histology. Int Ophthalmol Clin. 2009; 49(1):71-82. PMID: 19125066.
    Citations: 5     Fields:    Translation:Humans
  28. Fan BJ, Chen T, Grosskreutz C, Pasquale L, Rhee D, DelBono E, Haines JL, Wiggs JL. Lack of association of polymorphisms in homocysteine metabolism genes with pseudoexfoliation syndrome and glaucoma. Mol Vis. 2008; 14:2484-91. PMID: 19112534.
    Citations: 12     Fields:    Translation:Humans
  29. Rivier,D, Paula, JS, Kim, EC, Dohlman, CH and Grosskreutz, CL. Glaucoma and Keratoprosthesis: Role of Adjunctive Cyclophotocoagulation. Journal of Glaucoma. 2008; In press..
  30. Ergorul C, Ray A, Huang W, Darland D, Luo ZK, Grosskreutz CL. Levels of vascular endothelial growth factor-A165b (VEGF-A165b) are elevated in experimental glaucoma. Mol Vis. 2008 Aug 18; 14:1517-24. PMID: 18728749.
    Citations: 13     Fields:    Translation:Animals
  31. Wang, D.Y., Ray, A., Huang, W. and Grosskreutz, C.L. Alterations of prosurvival genes in retinal ganglion cells in experimental glaucoma. Society for Neuroscience Abstracts. 2008; (E-Abstract 344.18).
  32. Filippopoulos T, Paula JS, Torun N, Hatton MP, Pasquale LR, Grosskreutz CL. Periorbital changes associated with topical bimatoprost. Ophthalmic Plast Reconstr Surg. 2008 Jul-Aug; 24(4):302-7. PMID: 18645437.
    Citations: 30     Translation:Humans
  33. Grosskreutz, C. L. , Ergorul, C., Wang, D., Ray, A. and Ben, Y. Downstream consequences of hypoxia inducible factor 1-alpha (HIF-1α) activation in experimental glaucoma. Society for Neuroscience Abstracts. 2008; (E-Abstract 567.25).
  34. Fan BJ, Pasquale L, Grosskreutz CL, Rhee D, Chen T, DeAngelis MM, Kim I, del Bono E, Miller JW, Li T, Haines JL, Wiggs JL. DNA sequence variants in the LOXL1 gene are associated with pseudoexfoliation glaucoma in a U.S. clinic-based population with broad ethnic diversity. BMC Med Genet. 2008 Feb 06; 9:5. PMID: 18254956.
    Citations: 53     Fields:    Translation:HumansCells
  35. Wang, D., A. Ray, C. Ergorul, W. Huang, C.L. Grosskreutz. Gene Expression Profiling in Rat Retinal Ganglion Cells After Experimental Elevation of Intraocular Pressure. Investigative Ophthalmology and Visual science. 2008; 49(E-Abstract 5487).
  36. Ergorul, C., A. Ray, B.T. Lapp, D.Y. Wang, W. Huang, C.L. Grosskreutz. Endogenous Elevation of HIF1-α Levels Does Not Lead to Neovascularization in the Glaucomatous Retina. Investigative Ophthalmology and Visual Science. 2008; 49(E-Abstract 5497).
  37. Fan, B., L.R. Pasquale, C.L. Grosskreutz, T. Chen, D. Rhee, E.A. DelBono, J.L. Haines, J.L. Wiggs. Contribution of the CBS Gene to Pseudoexfoliation Glaucoma and Interaction With LOXL1. Investigative Ophthalmology and Visual Science. 2008; 49(E-Abstract 1721).
  38. Fileta JB, Huang W, Kwon GP, Filippopoulos T, Ben Y, Dobberfuhl A, Grosskreutz CL. Efficient estimation of retinal ganglion cell number: a stereological approach. J Neurosci Methods. 2008 May 15; 170(1):1-8. PMID: 18241929.
    Citations: 8     Fields:    Translation:AnimalsCells
  39. Huang W, Fileta JB, Filippopoulos T, Ray A, Dobberfuhl A, Grosskreutz CL. Hsp27 phosphorylation in experimental glaucoma. Invest Ophthalmol Vis Sci. 2007 Sep; 48(9):4129-35. PMID: 17724197.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  40. Ergorul, C. and Grosskreutz, C.L. Identification of Vegfa-164b mRNA in the rat retina and its upregulation in experimental glaucoma. Society for Neurosience Abstracts. 2007.
  41. Wentzloff JN, Grosskreutz CL, Pasquale LR, Walton DS, Chen TC. Endophthalmitis after glaucoma drainage implant surgery. Int Ophthalmol Clin. 2007; 47(2):109-15. PMID: 17450011.
    Citations: 2     Fields:    Translation:Humans
  42. Ergoul, C., Luo, Z.K., Huang, W., Ray, A., Fileta, J., Darland, D., Grosskreutz, C.L. Levels of VEGF-165b, a Recently Identified Inhibitory VEGF Isoform, Are Elevated in Experimental Glaucoma. Investigative Ophthalmology & Visual Science. 2007; 48(E-Abstract 3274).
  43. Alm, A and Grosskreutz, CL, editors. Glaucoma Section. ALBERT & JAKOBIEC'S PRINCIPLES & PRACTICE OF OPHTHALMOLOGY. 2007.
  44. Nakazawa T, Matsubara A, Noda K, Hisatomi T, She H, Skondra D, Miyahara S, Sobrin L, Thomas KL, Chen DF, Grosskreutz CL, Hafezi-Moghadam A, Miller JW. Characterization of cytokine responses to retinal detachment in rats. Mol Vis. 2006 Aug 07; 12:867-78. PMID: 16917487.
    Citations: 48     Fields:    Translation:AnimalsCells
  45. Brauner SC, Chen TC, Hutchinson BT, Chang MA, Pasquale LR, Grosskreutz CL. The course of glaucoma during pregnancy: a retrospective case series. Arch Ophthalmol. 2006 Aug; 124(8):1089-94. PMID: 16908810.
    Citations: 7     Fields:    Translation:Humans
  46. Filippopoulos T, Matsubara A, Danias J, Huang W, Dobberfuhl A, Ren L, Mittag T, Miller JW, Grosskreutz CL. Predictability and limitations of non-invasive murine tonometry: comparison of two devices. Exp Eye Res. 2006 Jul; 83(1):194-201. PMID: 16564045.
    Citations: 14     Fields:    Translation:Animals
  47. Huang W, Fileta J, Guo Y, Grosskreutz CL. Downregulation of Thy1 in retinal ganglion cells in experimental glaucoma. Curr Eye Res. 2006 Mar; 31(3):265-71. PMID: 16531284.
    Citations: 41     Fields:    Translation:AnimalsCells
  48. Huang, W., Rawe, I., Fileta, J.B., Grosskreutz, C.L. Calcineurin Cleavage Is Mediated by Calpain in Experimental Glaucoma: A Proteomic Analysis. Invetigative Ophthalmology & Visual Science. 2006; 47(E-Abstract 196).
  49. Pachydaki, S.I., Sobrin, L, Nakazawa, T., Zacks, D.N., Miller, J., Grosskreutz, C.L. Effect of Systemic Administration of FK506 in a Rat Model of Reintal Detachment. Investigative Ophthalmology & Visual Science. 2006; 47(E-Abstract 1045).
  50. Fileta, J.B., Huang, W., Guo, Y., Grosskreutz, C.L. . Thy1 Downregulation in Retinal Ganglion Cells (RGC) in Experimental Glaucoma. Invetigative Ophthalmology & Visual Science. 2006; 47(E-Abstract 1261).
  51. Zhao, J,C, Grosskreutz, C.L. Pasquale, L.R. Argon versus Selective Laser Trabeculoplasty in the Treatment of Open Angle Glaucoma. Int Ophthalmol Clin . 2005; 45(4):97-106.
  52. Huang W, Dobberfuhl A, Filippopoulos T, Ingelsson M, Fileta JB, Poulin NR, Grosskreutz CL. Transcriptional up-regulation and activation of initiating caspases in experimental glaucoma. Am J Pathol. 2005 Sep; 167(3):673-81. PMID: 16127148.
    Citations: 26     Fields:    Translation:AnimalsCells
  53. Huang W, Fileta JB, Dobberfuhl A, Filippopolous T, Guo Y, Kwon G, Grosskreutz CL. Calcineurin cleavage is triggered by elevated intraocular pressure, and calcineurin inhibition blocks retinal ganglion cell death in experimental glaucoma. Proc Natl Acad Sci U S A. 2005 Aug 23; 102(34):12242-7. PMID: 16103353.
    Citations: 43     Fields:    Translation:AnimalsCells
  54. Grosskreutz CL, Hänninen VA, Pantcheva MB, Huang W, Poulin NR, Dobberfuhl AP. FK506 blocks activation of the intrinsic caspase cascade after optic nerve crush. Exp Eye Res. 2005 May; 80(5):681-6. PMID: 15862175.
    Citations: 9     Fields:    Translation:AnimalsCells
  55. Nakazawa, T., Matsubara, A., Chen D.F., Sobrin, L., Noda, K., Skondra, D., Grosskreutz, C.L., Hafezi-Moghadam, A., Miller, J.W. Characterization of Cytokine Responses to Retinal Detachment in Rats. Invesigative Ophthalmology & Visual Science. 2005; 46(E-Abstract 5549).
  56. Pachydaki, S.I., Sobrin, L., Nakazawa, T., Grosskreutz, C.L., Zacks, D.N., Miller, J.W. Characterization of Effects of Systemic Antibiotics in a Rat Model of Retinal Detachment. Investigative Ophthalmology & Visual Science. 2005; 46(E-Abstract 5572).
  57. Grosskreutz, C.L., Huang, W., Dobberfuhl, A., Filippopoulos, t., Fileta, J. Upregulation of Caspase 8 and 9 mRNA Levels in Retinal Ganglion Cells (RGC) in Experimental Glaucoma. Investigative Ophthalmology & Visual Science. 2005; 46(E-Abstract 1254).
  58. Sobrin, L., Pachydaki, S.I., Nakazawa, T., Grosskreutz, C.L., Zacks, D.N., Miller, J.W. Effect of Systemic Neuroprotective Agents on Photoreceptor Apoptosis in a Rat Model of Retinal Detachement. Investigative Ophthalmology & Visual Science. 2005; 46(E-Abstract 5521).
  59. Filippopoulos, T.,Matsubara, A., Danias, J., Huang, W., Mittag, T.W.,Miller, J. W.,Grosskreutz, C.L. . Accuracy and Sensitivity of Two Non-Invasive Tonometers for the Measurement of Intraocular Pressure (IOP) in the Mouse. Investigative Ophthalmology & Visual Science. 2005; 46(E-Abstract 1257).
  60. Huang, W., Dobberfuhl, A.P., Filippopoulos, T., Fileta, J.B., Kwon, G.P., Grosskreutz, C.L. Neuroprotection From Calcineurin-Mediated Retinal Ganglion Cell Apoptosis by FK506 in Experimental Glaucoma. Investigative Ophthalmology & Visual Science. 2005; 46(E-Abstract 4726).
  61. Kwon, G.P.,Huang, W., Filippopoulos, T., Fileta, J.B., Grosskreutz, C.L. The Use of Stereologic Counting Methods to Assess Retinal Ganglion Cell (RGC) Loss. Investigative Ophthalmology & Visual Science. 2005; 46(E-Abstract 1261).
  62. Zhao JC, Grosskreutz CL, Pasquale LR. Argon versus selective laser trabeculoplasty in the treatment of open angle glaucoma. Int Ophthalmol Clin. 2005; 45(4):97-106. PMID: 16199969.
    Citations: 1     Fields:    Translation:Humans
  63. Sobrin L, Young TA, Sharma A, Nakazawa T, Grosskreutz CL, Zacks DN. Pigment epithelial-derived factor (PEDF) inhibits apoptosis in a rat model of retinal detachment. Investigative Ophthalmology and Visual Science. 2004; 45(E-Abstract 2064).
  64. Dohlman CH, Barnes SD, Ma JJ, Grosskreutz CL, Pasquale LR, Chen TC, Rubin PA. Diverting Aqueous Humor to Distant Sites in Severe Glaucoma - An Update. Investigative Ophthalmology and Visual Science. 2004; 45(E-Abstract 920).
  65. Brauner SC, Chen TC, Chang MA, Pasquale LR, Grosskreutz CL. Glaucoma During Pregnancy. Invetigative Ophthalmology and Visual Science. 2004; 45(E-Abstract 5568).
  66. Filippopoulos T, Matsubara A, Huang W, Ahmed E, Dobberfuhl A, Miller JW, Grosskreutz CL. Comparison of two non-invasive tonometers for the measurement of Intraocular Pressure (IOP) in the Mouse. Investigative Ophthalmology and Visual Science. 2004; 45(E-Abstract 2169).
  67. Huang W, Dobberfuhl A, Ingelsson M, Filippopoulos T, Grosskreutz CL. Detection of gene expression changes of caspase 8 and Thy1 in rat retinal ganglion cells after optic nerve crush using laser capture microdissection (LCM) with real-time PCR. Investigative Ophthalmology and Visual Science. 2004; 45(E-Abstract 2160).
  68. Dobberfuhl A, Huang W, Filippopoulos T, Grosskreutz CL. Elevation in Hsp27 and the Corresponding Increase in Procaspase 9 Protein Levels Following Induction of Experimental Glaucoma. Investigative Ophthalmology and Visual Science. 2004; 45(E-Abstract 2173).
  69. Fine LC, Chen TC, Grosskreutz CL, Pasquale LR. Management and prevention of thin, cystic blebs. Int Ophthalmol Clin. 2004; 44(1):29-42. PMID: 14704518.
    Citations:    Fields:    Translation:Humans
  70. Grosskreutz CL, Dobberfuhl A, Filippopoulos T, Huang W. Calcineurin Activation in Experimental Glaucoma in the Rat. Investigative Ophthalmology and Visual Science. 2004; 45(E-Abstract 2150).
  71. Young TA, Nakazawa T, Sobrin L, Sharma A, Grosskreutz CL, Gragoudas ES, Miller JW. Modulation of Apoptosis Following Combination PEDF and Photodynamic Therapy for Choroidal Neovascularization in the Rat Model. Investigative Ophthalmology and Visual Science. 2004; 45(E-Abstract 2231).
  72. Adelman RA, Brauner SC, Afshari NA, Grosskreutz CL. Cataract formation after initial trabeculectomy in young patients. Ophthalmology. 2003 Mar; 110(3):625-9. PMID: 12623833.
    Citations: 6     Fields:    Translation:Humans
  73. Zacks DN, Hänninen V, Pantcheva M, Ezra E, Grosskreutz C, Miller JW. Caspase activation in an experimental model of retinal detachment. Invest Ophthalmol Vis Sci. 2003 Mar; 44(3):1262-7. PMID: 12601057.
    Citations: 39     Fields:    Translation:AnimalsCells
  74. Zacks, D.N., Hanninen, V., Pantcheva, M. Grosskreutz, C.L., and Miller, J.W. Caspase Activation in an Experimemtal Model of Retinal Detachment. Investigative Ophthalmology and Visual Science. 2003; 44(E-Abstract 2951).
  75. Young, T.A., Pantcheva, M.B., Connolly, E.J., Mandelcorn, M.S., Whiteside, Grosskreutz, C.L., Gragoudas, E.S., and Miller, J.W. Apoptosis in Acute Photodynamic Therapy of Choroidal Neovascularization in the Rat Model. Investigative Ophthalmology and Visual Science. 2003; 44(E-Abstract 3932).
  76. Pantcheva, M.B., Hanninen, V.A., Poulin, N.R., Dobberfuhl, A.P., and Grosskreutz, C.L. Phosphorylation of Akt and Activation of Caspase 9 After Optic Nerve Crush in Rats. Investigative Ophthalmology and Visual Science. 2003; 44(E-Abstract 3348).
  77. Hänninen VA, Pantcheva MB, Freeman EE, Poulin NR, Grosskreutz CL. Activation of caspase 9 in a rat model of experimental glaucoma. Curr Eye Res. 2002 Dec; 25(6):389-95. PMID: 12789547.
    Citations: 21     Fields:    Translation:AnimalsCells
  78. Halpern DL, Grosskreutz CL. Glaucomatous optic neuropathy: mechanisms of disease. Ophthalmol Clin North Am. 2002 Mar; 15(1):61-8. PMID: 12064082.
    Citations: 15     Fields:    Translation:Humans
  79. Dohlman, C.H., Grosskreutz, C.L., Dudenhoefer, E.J., Rubin, P. Tube Extension from Ahmed Shunt Plate to Lacrimal Sac or Ethmoid Sinuses in Patients with Keratoprosthesis. Investigative Ophthalmology & Visual Science. 2002; 43(E-Abstract 1060).
  80. Sankar PS, Chen TC, Grosskreutz CL, Pasquale LR. Traumatic hyphema. Int Ophthalmol Clin. 2002; 42(3):57-68. PMID: 12131583.
    Citations: 1     Fields:    Translation:Humans
  81. Pantcheva, M.B., Poulin, N.R., Luukkaa, V.A., and Grosskreutz, C.L. Death Receptor Complex Formation After Optic Nerve Crush in Rats. Investigative Ophthalmology and Visual Science. 2002; 43(E-Abstract 4054).
  82. Grosskreutz, C.L., Luukkaa, V.A., Pantcheva, M.B., Poulin, N.R. Activation of Caspase 9 in a Rat Model of Experimental Glaucoma. Investigatvie Ophthalmology & Visual Science. 2002; 43(E-Abstract 4058).
  83. Sankar PS, Pasquale LR, Grosskreutz CL. Uveal effusion and secondary angle-closure glaucoma associated with topiramate use. Arch Ophthalmol. 2001 Aug; 119(8):1210-1. PMID: 11483094.
    Citations: 17     Fields:    Translation:Humans
  84. Chen TC, Ang RT, Grosskreutz CL, Pasquale LR, Fan JT. Brimonidine 0.2% versus apraclonidine 0.5% for prevention of intraocular pressure elevations after anterior segment laser surgery. Ophthalmology. 2001 Jun; 108(6):1033-8. PMID: 11382625.
    Citations: 1     Fields:    Translation:HumansCTClinical Trials
  85. Grosskreutz, C.L. Becker-Shaffer's Diagnosis and Therapy of the Glaucomas. Arch. Ophthalmology. 2001; 119(312).
  86. Luukkaa, V.A., Poulin, N.R., and Grosskreutz, C.L. Increased Caspase 3 Expression in the Saline Model of Experimental Glaucoma in the Rat. Investigative Ophthalmology and Visual Science. 2001; 42(4).
  87. Luukkaa, V.A., Poulin, N.R., McNamara, M., Pantcheva, M.B. and Grosskreutz, C.L. Effect of FK506 on Caspase 3 & 9 After Optic Nerve Crush (ONC) in the Rat. Society for Neuroscience Abstract. 2001.
  88. Dohlman, C.H., Grosskreutz, C.L., Dudenhoefer, E.J., and Rubin, P.A.D. Can a Glaucoma Shunt Tube be Safely Extended to the Lacrimal Sac or the Ethmoid Sinus in Keratoprosthesis Patients?. Dig J Ophthalmology. 2001; 7(3).
  89. Farkas RH, Grosskreutz CL. Apoptosis, neuroprotection, and retinal ganglion cell death: an overview. Int Ophthalmol Clin. 2001; 41(1):111-30. PMID: 11198138.
    Citations: 20     Fields:    Translation:HumansCells
  90. Kim, E.C., Kahn, B. Dohlman, C.H., and Grosskreutz, C.L. The Use of Diode Laser Cyclophtocoagulation (CYC) for Prevention and treatment of Glaucoma Associated with Keratoprosthesis (Kpro). Investigative Ophthalmology and Visual Science. 2001; 42(4).
  91. Borboli, S., Fan, J.T., Ang, R.T., Grosskreutz, C.L., Pasquale, L.R. and Chen, T.C. Brimonidine 0.2% Versus Apraclonidine 0.5% for Prevention of Intraocular Pressure Elevations Following Neodymium (Nd):YAG Anterior Segment Laser Surgery. Investigative Ophthalmology and Visual Science. 2001; 42(4).
  92. Freeman EE, Grosskreutz CL. The effects of FK506 on retinal ganglion cells after optic nerve crush. Invest Ophthalmol Vis Sci. 2000 Apr; 41(5):1111-5. PMID: 10752948.
    Citations: 10     Fields:    Translation:AnimalsCells
  93. Freeman, E.E., and Grosskreutz, C.L. Retinal Ganglion Cells (RGC) Die by Apoptosis in the Saline Model of Experimental Glaucoma in the Rat. Investigative Ophthalmology and Visual Science. 2000; 41(4):4769.
  94. Ang RE, Grosskreutz CL. Bleb complications after filtration surgery. Int Ophthalmol Clin. 2000; 40(1):137-48. PMID: 10713921.
    Citations:    Fields:    Translation:Humans
  95. Gasch AT, Foster CS, Grosskreutz CL, Pasquale LR. Postoperative sympathetic ophthalmia. Int Ophthalmol Clin. 2000; 40(1):69-84. PMID: 10713915.
    Citations: 7     Fields:    Translation:Humans
  96. Simon PD, McConnell J, Zurakowski D, Vorwerk CK, Naskar R, Grosskreutz CL, Dreyer EB. Thy-1 is critical for normal retinal development. Brain Res Dev Brain Res. 1999 Nov 18; 117(2):219-23. PMID: 10567740.
    Citations: 8     Fields:    Translation:AnimalsCells
  97. Grosskreutz CL, Anand-Apte B, Dupláa C, Quinn TP, Terman BI, Zetter B, D'Amore PA. Vascular endothelial growth factor-induced migration of vascular smooth muscle cells in vitro. Microvasc Res. 1999 Sep; 58(2):128-36. PMID: 10458928.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  98. Grosskreutz CL, Katowitz WR, Freeman EE, Dreyer EB. Lidocaine toxicity to rat retinal ganglion cells. Curr Eye Res. 1999 May; 18(5):363-7. PMID: 10372998.
    Citations: 6     Fields:    Translation:AnimalsCells
  99. Heng JE, Zurakowski D, Vorwerk CK, Grosskreutz CL, Dreyer EB. Cation channel control of neurite morphology. Brain Res Dev Brain Res. 1999 Mar 12; 113(1-2):67-73. PMID: 10064876.
    Citations: 4     Fields:    Translation:AnimalsCells
  100. Afshari, M.A., Afshari, N.A., and Grosskreutz, C.L. Cataract Formation After Initial Trabeculectomy in Young Patients. Investigative Ophthalmology and Visual Science. 1999; 40(4):S288.
  101. Freeman, E.E., and Grosskreutz, C.L. The Effects of FK506 on Retinal Ganglion Cells After Optic Nerve Crush (ONC). Investigative Ophthalmology and Visual Science. 1999; 40(4):S266.
  102. Leuenberger EU, Grosskreutz CL, Walton DS, Pasquale LR. Advances in aqueous shunting procedures. Int Ophthalmol Clin. 1999; 39(1):139-53. PMID: 10083912.
    Citations:    Fields:    Translation:Humans
  103. Chen TC, Pasquale LR, Walton DS, Grosskreutz CL. Diode laser transscleral cyclophotocoagulation. Int Ophthalmol Clin. 1999; 39(1):169-76. PMID: 10083914.
    Citations: 4     Fields:    Translation:Humans
  104. Zurakowski D, Vorwerk CK, Gorla M, Kanellopoulos AJ, Chaturvedi N, Grosskreutz CL, Lipton SA, Dreyer EB. Nitrate therapy may retard glaucomatous optic neuropathy, perhaps through modulation of glutamate receptors. Vision Res. 1998 May; 38(10):1489-94. PMID: 9667013.
    Citations: 7     Fields:    Translation:Humans
  105. Graham, K.F., Grosskreutz, C.L., Oates, D.C. and Jakobiec, F.A. Malignant Iris Melanoma with Diffuse Iris Pigmentation and Glaucoma, But No Mass. Investigative Ophthalmology and Visual Science. 1998; 39(4):S222.
  106. Grosskreutz, C.L., Katowitz, W.R., Freeman, E.E., and Dreyer, E.B. The Effects of Lidocaine on Rat Retinal Ganglion Cells. Investigative Ophthalmology and Visual Science. 1998; 39(4):S260.
  107. Grosskreutz, C.L., Katowitz, W.R., D'Amore P.A., and Dreyer, E.B. Experimentally-Induced Increased Intraocular Pressure (IOP) Produced by Methylcellulose (MC)in the Anterior Chamber (AC) of the Guinea Pig(GP). Investigative Ophthalmology and Visual Science. 1997; 38(4):S161.
  108. Dreyer EB, Grosskreutz CL. Excitatory mechanisms in retinal ganglion cell death in primary open angle glaucoma (POAG). Clin Neurosci. 1997; 4(5):270-3. PMID: 9292254.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  109. Hassessian, H.M., Pogan, L., Grosskreutz, C.L., and D'Amore, P.A. The KDR Receptor for Vascular Endothelial Growth Factor (VEGF165) Evokes Ca2+Influx in Bovine Retinal Capillary Endothelial Cells. Investigative Ophthalmology and Visual Science. 1997; 38(4):S500.
  110. Grosskreutz, C.L., Anand-Apte, B., Quinn, T., Terman, B., and D'Amore, P.A. Vascular Endothelial Growth Factor (VEGF) is a Chemoattractant for Vascular Smooth Muscle Cells (SMC). Invetigative Ophthalmology and Visual Science. 1996; 37(3):S470.
  111. Netland PA, Grosskreutz CL, Feke GT, Hart LJ. Color Doppler ultrasound analysis of ocular circulation after topical calcium channel blocker. Am J Ophthalmol. 1995 Jun; 119(6):694-700. PMID: 7785682.
    Citations: 12     Fields:    Translation:HumansCTClinical Trials
  112. Grosskreutz C, Aquino N, Dreyer EB. Cyclodialysis. Int Ophthalmol Clin. 1995; 35(1):105-9. PMID: 7751122.
    Citations: 2     Fields:    Translation:Humans
  113. Grosskreutz C, Netland PA. Low-tension glaucoma. Int Ophthalmol Clin. 1994; 34(3):173-85. PMID: 7960512.
    Citations: 3     Fields:    Translation:Humans
  114. Grosskreutz, C.L., Kaiser, P.K. and Dreyer, E.B. An Evaluation of the Risk of Glaucoma Secondary to Inhaled Steroid Use. Investigative Ophthalmology and Visual Science. 1994; 35(4):2179.
  115. Grosskreutz, C.L., and Lamkin, J.C. Pediatric Ophthalmology. The Massachusetts Eye and Ear Infirmary Review Manual for Ophthalmology, J.C. Lamkin, ed. 1993.
  116. Grosskreutz, C.L., Aquino, N., Hart, L. and Netland, P. The Effect of Topical Calcium Channel Blockers on Intraocular Pressure and Ocular Blood Velocity. Ophthalmology. 1993; 100(9A):131.
  117. Grosskreutz C, Smith LB. Neonatal conjunctivitis. Int Ophthalmol Clin. 1992; 32(1):71-9. PMID: 1537666.
    Citations:    Fields:    Translation:Humans
  118. Jacob HJ, Alper RH, Grosskreutz CL, Lewis SJ, Brody MJ. Vascular tone influences arterial pressure lability after sinoaortic deafferentation. Am J Physiol. 1991 Feb; 260(2 Pt 2):R359-67. PMID: 1996723.
    Citations: 6     Fields:    Translation:Animals
  119. Volpe, N.J., Azar, D.T., and Grosskreutz, C.L. Corneal Rupture and Iridodialysis 6 Years after Radial Keratotomy. Proceedings of the American Society of Cataract and Refractive Surgeons, 1991 Meeting, Boston, MA. 1991.
  120. Brody, M.J., Varner, K.J., Lewis, S.J., Machado, B., and Grosskreutz, C.L. Are Vagal Pregangionic Neurons Located in Rostral Ventromedical Medulla (RVMM) of Rat?. The FASEB Journal. 1990.
  121. Varner, K.J., Vasquez, E.C., Lewis, S.J., Machado, B.H., Grosskreutz, C.L., Simon, J.S., and Brody, M.J. Regulation of Autonomic Carodiovascular Function by the Rostral Ventromedical Medulla (RVMM). George Kunow and John Ciriello (eds,), Central Neural Mechanisms in Blood Pressure Regulation,. 1990.
  122. Grosskreutz, C.L. Characterization of Subregions of the Ventral Portion of the Rostral Medulla Oblongata in Neural Control of Arterial Pressure. Ph.D. Thesis. 1989.
  123. Varner, K.J., Grosskreutz, C.L., Lewis, S.J. and Brody, M.J. Differntial Control of Sympathetic Nerve Activity (SNA)by the Rostral Ventrolateral (RVLM) and Rostral Ventromedical (RVMM) Medulla. The FASEB Journal. 1989; 3(3):A529.
  124. Grosskreutz, C.L., and Brody, M.J. Does Neurogenic Vasomotor Tone Depend on the Functional Integrity of Cell Bodies in Rostral Ventral Medulla?. The FASEB Journal. 1989.
  125. Van Allen, J.A., Grosskreutz, C.L. Relativistic Electrons in Saturn's Inner Magnetosphere and an Estimate of their Synchrotron Emission. Journal of Geophysical Research. 1989; 94(A7):8731 - 8738.
  126. Varner KJ, Grosskreutz CL, Cox BF, Brody MJ. Differential regulation of sympathetic nerve activity by lateral and medial subregions of the rostral ventral medulla. Prog Brain Res. 1989; 81:99-103. PMID: 2616791.
    Citations: 2     Fields:    Translation:Animals
  127. Barrés CP, Lewis SJ, Grosskreutz CL, Varner KJ, Brody MJ. Role of renal nerves in experimental hypertension: evaluation of neurogenic mechanisms. Clin Exp Hypertens A. 1989; 11 Suppl 1:117-24. PMID: 2743588.
    Citations: 3     Fields:    Translation:Animals
  128. Grosskreutz CL, Brody MJ. Regional hemodynamic responses to central administration of corticotropin-releasing factor (CRF). Brain Res. 1988 Mar 01; 442(2):363-7. PMID: 3259447.
    Citations: 3     Fields:    Translation:Animals
  129. Brody, M.J., Cox, B.F., Grosskreutz, C.L., Portis, L.R., and Varner, K.J. Two Functionally and Anatomically Distinct Regions of Rostral Ventral Medulla Control Tonic Sympathetic Maintenance of Arterial Pressure. Proceedings of the Satellite Symposium, Society for Neuroscience, London, Ontario, Canada, Nov. 11-12. 1988.
  130. Grosskreutz, C.L., Hyman, B.T., and Brody, M.J. Acute Cardiovascular Affects of 9-Amino-1,2,3,4-tetrahydroacridine (THA) in Rats. Neurology. 1988; 38(Supp.1):323.
  131. Portis, L.R., Grosskreutz, C.L., and Brody, M.J. Effect of Anesthesia on the Depressor Response Produced by Injection of Lidocaine in Rostral Ventrolateral Medulla (RVLM). The FASEB Journal. 1988; 2(5):A1488.
  132. Varner, K.J., Grosskreutz, C.L., and Brody, M.J. Contribution of the Rostral Ventrolateral (RVLM) and Rostral Bentromedial (RVMM) Medulla to Maintenance of Sympathetic nerve Activity (SNA). Society of Neuroscience Abstracts. 1988; 14(2):1182.
  133. Grosskreutz, C.L., and Brody, M.J. Role of Rostral Ventrolateral Medulla (RVLM) in Neural Control of Arterial Pressure (AP). The FASEB Journal. 1988; 2(5):A1487.
  134. Grosskreutz, C.L., and Brody, M.J. Regional Hemodynamic Responses to Central Administration of Corticotropin-Releasing Factor (CRF). Federation Proceedings. 1987; 46(3):495.
  135. Florentine MS, Grosskreutz CL, Chang W, Hartnett JA, Dunn VD, Ehrhardt JC, Fleagle SR, Collins SM, Marcus ML, Skorton DJ. Measurement of left ventricular mass in vivo using gated nuclear magnetic resonance imaging. J Am Coll Cardiol. 1986 Jul; 8(1):107-12. PMID: 3711505.
    Citations: 13     Fields:    Translation:Animals
  136. Grosskreutz, C.L., Alper, R.H., and Brody, M.J. Cardiovascular Responses to Microinjection of Corticotropin Releasing Factor (CRF) in the Hypothalamic Paraventricular Nucleus (PVN). Federation Proceedings. 1986; 45(3):392.
  137. Florentine,Michael, Grosskreutz,Cynthia, Chang, Wei, Ehrhardt,James, Dunn,Val, Skorton,David, and Marcus,Melvin. Gated Magnetic Resonancee Imaging of the In Vivo Heart: Determination of Left Ventricular Mass in Dogs. Pediatric Research. 1985; 19(4, Part II):127A.
  138. Grosskreutz, C.L., Ehrhardt, J.C., and Rezai, K. Estimation of Regional Cerebral Blood Flow: Flow Simulation and Phantom Studies. University of Iowa Student Medical Research Day. 1984.
  139. Grosskreutz, C.L. Distribution of Energetic Electrons (0.040 < Ee < 21 MeV) in Saturn's Inner Magnetosphere. M.S. Thesis. 1982.
  140. Grosskreutz, C.L., Randall, B.A., and Van Allen, J.A. Angular Distributions of Energetic Electrons in the Saturnian Magnetosphere. EOS. 1981; 62:372.
  141. Grosskreutz, C.L. An Estimate of the Synchrotron Radiation from Saturn. University of Iowa Research Report. 1980; (80):37.
  142. VAN Allen JA, Thomsen MF, Randall BA, Rairden RL, Grosskreutz CL. Saturn's Magnetosphere, Rings, and Inner Satellites. Science. 1980 Jan 25; 207(4429):415-21. PMID: 17833551.
    Citations: 1     Fields:    
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.