Harvard Catalyst Profiles

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Joseph Fitzgerald Arboleda-Velasquez, Ph.D., M.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. U01NS119560 (ARBOLEDA-VELASQUEZ, JOSEPH) Jan 15, 2021 - Dec 31, 2025
    NIH
    Humanization of a Notch 3 agonist antibody for pre-clinical development of a CADASIL treatment
    Role: Principal Investigator
  2. RF1NS110048 (ARBOLEDA-VELASQUEZ, JOSEPH) Sep 1, 2018 - May 31, 2023
    NIH
    Charting vascular contributions to white matter disease in familial Alzheimer's disease and CADASIL
    Role: Principal Investigator
  3. UH2NS100121 (ARBOLEDA-VELASQUEZ, JOSEPH) Sep 30, 2016 - Aug 31, 2021
    NIH
    Exploring the Role of Aging in Cerebral Ischemic Small Vessel Disease Using Notch3 Mutant Mice
    Role: Principal Investigator
  4. UH3NS100121 (ARBOLEDA-VELASQUEZ, JOSEPH) Sep 30, 2016 - Aug 31, 2021
    NIH
    Exploring the Role of Aging in Cerebral Ischemic Small Vessel Disease Using Notch3 Mutant Mice
    Role: Principal Investigator
  5. R00EY021624 (ARBOLEDA-VELASQUEZ, JOSEPH) May 1, 2014 - Apr 30, 2017
    NIH
    Notch and TGF-beta in the Control of Retinal Vascular Integrity
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Fox-Fuller JT, Artola A, Chen K, Pulsifer M, Ramirez D, Londono N, Aguirre-Acevedo DC, Vila-Castelar C, Baena A, Martinez J, Arboleda-Velasquez JF, Langbaum JB, Tariot PN, Reiman EM, Lopera F, Quiroz YT. Sex Differences in Cognitive Abilities Among Children With the Autosomal Dominant Alzheimer Disease Presenilin 1 E280A Variant From a Colombian Cohort. JAMA Netw Open. 2021 Aug 02; 4(8):e2121697. PMID: 34463747.
    Citations:    Fields:    
  2. Jacobs HIL, Schoemaker D, Torrico-Teave H, Zuluaga Y, Velilla-Jimenez L, Ospina-Villegas C, Lopera F, Arboleda-Velasquez JF, Quiroz YT. Specific Abnormalities in White Matter Pathways as Interface to Small Vessels Disease and Cognition in Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy Individuals. Brain Connect. 2021 Jun 29. PMID: 33980027.
    Citations:    Fields:    
  3. Schoemaker D, Arboleda-Velasquez JF. Notch3 Signaling and Aggregation as Targets for the Treatment of CADASIL and Other NOTCH3-Associated Small-Vessel Diseases. Am J Pathol. 2021 Apr 22. PMID: 33895122.
    Citations:    Fields:    
  4. O'Hare M, Amarnani D, Whitmore HAB, An M, Marino C, Ramos L, Delgado-Tirado S, Hu X, Chmielewska N, Chandrahas A, Fitzek A, Heinrich F, Steurer S, Ondruschka B, Glatzel M, Krasemann S, Sepulveda-Falla D, Lagares D, Pedron J, Bushweller JH, Liu P, Arboleda-Velasquez JF, Kim LA. Targeting Runt-Related Transcription Factor 1 Prevents Pulmonary Fibrosis and Reduces Expression of Severe Acute Respiratory Syndrome Coronavirus 2 Host Mediators. Am J Pathol. 2021 07; 191(7):1193-1208. PMID: 33894177.
    Citations:    Fields:    Translation:AnimalsCells
  5. Schoemaker D, Velilla-Jimenez L, Zuluaga Y, Baena A, Ospina C, Bocanegra Y, Alvarez S, Ochoa-Escudero M, Guzmán-Vélez E, Martinez J, Lopera F, Arboleda-Velasquez JF, Quiroz YT. Global Cardiovascular Risk Profile and Cerebrovascular Abnormalities in Presymptomatic Individuals with CADASIL or Autosomal Dominant Alzheimer's Disease. J Alzheimers Dis. 2021; 82(2):841-853. PMID: 34092645.
    Citations:    Fields:    
  6. Armstrong GW, Kim LA, Vingopoulos F, Park JY, Garg I, Kasetty M, Silverman RF, Zeng R, Douglas VP, Lopera F, Baena A, Giraldo M, Norton D, Cronin-Golomb A, Arboleda-Velasquez JF, Quiroz YT, Miller JB. Retinal Imaging Findings in Carriers With PSEN1-Associated Early-Onset Familial Alzheimer Disease Before Onset of Cognitive Symptoms. JAMA Ophthalmol. 2021 01 01; 139(1):49-56. PMID: 33180114.
    Citations: 2     Fields:    Translation:Humans
  7. Gonzalez-Buendia L, Delgado-Tirado S, An M, O'Hare M, Amarnani D, A B Whitmore H, Zhao G, Ruiz-Moreno JM, Arboleda-Velasquez JF, Kim LA. Treatment of Experimental Choroidal Neovascularization via RUNX1 Inhibition. Am J Pathol. 2021 03; 191(3):418-424. PMID: 33345998.
    Citations:    Fields:    Translation:Animals
  8. Delgado-Tirado S, Amarnani D, Zhao G, Rossin EJ, Eliott D, Miller JB, Greene WA, Ramos L, Arevalo-Alquichire S, Leyton-Cifuentes D, Gonzalez-Buendia L, Isaacs-Bernal D, Whitmore HAB, Chmielewska N, Duffy BV, Kim E, Wang HC, Ruiz-Moreno JM, Kim LA, Arboleda-Velasquez JF. Topical delivery of a small molecule RUNX1 transcription factor inhibitor for the treatment of proliferative vitreoretinopathy. Sci Rep. 2020 11 30; 10(1):20554. PMID: 33257736.
    Citations: 1     Fields:    Translation:HumansAnimals
  9. Whitmore HAB, Amarnani D, O'Hare M, Delgado-Tirado S, Gonzalez-Buendia L, An M, Pedron J, Bushweller JH, Arboleda-Velasquez JF, Kim LA. TNF-a signaling regulates RUNX1 function in endothelial cells. FASEB J. 2021 02; 35(2):e21155. PMID: 33135824.
    Citations:    Fields:    Translation:HumansAnimalsCells
  10. Ospina C, Arboleda-Velasquez JF, Aguirre-Acevedo DC, Zuluaga-Castaño Y, Velilla L, Garcia GP, Quiroz YT, Lopera F. Genetic and nongenetic factors associated with CADASIL: A retrospective cohort study. J Neurol Sci. 2020 Dec 15; 419:117178. PMID: 33091750.
    Citations:    Fields:    Translation:Humans
  11. Schoemaker D, Zuluaga Y, Viswanathan A, Schirmer MD, Torrico-Teave H, Velilla L, Ospina C, Ospina GG, Lopera F, Arboleda-Velasquez JF, Quiroz YT. The INECO Frontal Screening for the Evaluation of Executive Dysfunction in Cerebral Small Vessel Disease: Evidence from Quantitative MRI in a CADASIL Cohort from Colombia - Corrigendum. J Int Neuropsychol Soc. 2020 11; 26(10):1052. PMID: 32967748.
    Citations:    Fields:    
  12. Schoemaker D, Zuluaga Y, Viswanathan A, Shrimer D, Torrico-Teave H, Velilla L, Ospina C, Ospina GG, Lopera F, Arboleda-Velasquez JF, Quiroz YT. The INECO Frontal Screening for the Evaluation of Executive Dysfunction in Cerebral Small Vessel Disease: Evidence from Quantitative MRI in a CADASIL Cohort from Colombia. J Int Neuropsychol Soc. 2020 11; 26(10):1006-1018. PMID: 32487276.
    Citations:    Fields:    
  13. Quiroz YT, Zetterberg H, Reiman EM, Chen Y, Su Y, Fox-Fuller JT, Garcia G, Villegas A, Sepulveda-Falla D, Villada M, Arboleda-Velasquez JF, Guzmán-Vélez E, Vila-Castelar C, Gordon BA, Schultz SA, Protas HD, Ghisays V, Giraldo M, Tirado V, Baena A, Munoz C, Rios-Romenets S, Tariot PN, Blennow K, Lopera F. Plasma neurofilament light chain in the presenilin 1 E280A autosomal dominant Alzheimer's disease kindred: a cross-sectional and longitudinal cohort study. Lancet Neurol. 2020 06; 19(6):513-521. PMID: 32470423.
    Citations: 12     Fields:    Translation:HumansCells
  14. Reiman EM, Arboleda-Velasquez JF, Quiroz YT, Huentelman MJ, Beach TG, Caselli RJ, Chen Y, Su Y, Myers AJ, Hardy J, Paul Vonsattel J, Younkin SG, Bennett DA, De Jager PL, Larson EB, Crane PK, Keene CD, Kamboh MI, Kofler JK, Duque L, Gilbert JR, Gwirtsman HE, Buxbaum JD, Dickson DW, Frosch MP, Ghetti BF, Lunetta KL, Wang LS, Hyman BT, Kukull WA, Foroud T, Haines JL, Mayeux RP, Pericak-Vance MA, Schneider JA, Trojanowski JQ, Farrer LA, Schellenberg GD, Beecham GW, Montine TJ, Jun GR. Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study. Nat Commun. 2020 02 03; 11(1):667. PMID: 32015339.
    Citations: 46     Fields:    Translation:Humans
  15. Arboleda-Velasquez JF, Lopera F, O'Hare M, Delgado-Tirado S, Marino C, Chmielewska N, Saez-Torres KL, Amarnani D, Schultz AP, Sperling RA, Leyton-Cifuentes D, Chen K, Baena A, Aguillon D, Rios-Romenets S, Giraldo M, Guzmán-Vélez E, Norton DJ, Pardilla-Delgado E, Artola A, Sanchez JS, Acosta-Uribe J, Lalli M, Kosik KS, Huentelman MJ, Zetterberg H, Blennow K, Reiman RA, Luo J, Chen Y, Thiyyagura P, Su Y, Jun GR, Naymik M, Gai X, Bootwalla M, Ji J, Shen L, Miller JB, Kim LA, Tariot PN, Johnson KA, Reiman EM, Quiroz YT. Resistance to autosomal dominant Alzheimer's disease in an APOE3 Christchurch homozygote: a case report. Nat Med. 2019 11; 25(11):1680-1683. PMID: 31686034.
    Citations: 78     Fields:    Translation:Humans
  16. Schoemaker D, Quiroz YT, Torrico-Teave H, Arboleda-Velasquez JF. Clinical and research applications of magnetic resonance imaging in the study of CADASIL. Neurosci Lett. 2019 04 17; 698:173-179. PMID: 30634011.
    Citations: 3     Fields:    Translation:Humans
  17. Rendon J, Zuluaga Y, Velilla L, Ochoa J, Arboleda-Velasquez JF, Budson A, Lopera F, Quiroz YT. Event-related potential correlates of recognition memory in asymptomatic individuals with CADASIL. Brain Res. 2019 03 15; 1707:74-78. PMID: 30445028.
    Citations: 1     Fields:    Translation:Humans
  18. Zuluaga-Castaño Y, Montoya-Arenas DA, Velilla L, Ospina C, Arboleda-Velasquez JF, Quiroz YT, Lopera F. Cognitive performance in asymptomatic carriers of mutations R1031C and R141C in CADASIL. Int J Psychol Res (Medellin). 2018 Jul-Dec; 11(2):46-55. PMID: 32612778.
    Citations:    
  19. Quiroz YT, Sperling RA, Norton DJ, Baena A, Arboleda-Velasquez JF, Cosio D, Schultz A, Lapoint M, Guzman-Velez E, Miller JB, Kim LA, Chen K, Tariot PN, Lopera F, Reiman EM, Johnson KA. Association Between Amyloid and Tau Accumulation in Young Adults With Autosomal Dominant Alzheimer Disease. JAMA Neurol. 2018 05 01; 75(5):548-556. PMID: 29435558.
    Citations: 53     Fields:    Translation:Humans
  20. Amarnani D, Machuca-Parra AI, Wong LL, Marko CK, Stefater JA, Stryjewski TP, Eliott D, Arboleda-Velasquez JF, Kim LA. Effect of Methotrexate on an In Vitro Patient-Derived Model of Proliferative Vitreoretinopathy. Invest Ophthalmol Vis Sci. 2017 08 01; 58(10):3940-3949. PMID: 28777835.
    Citations: 8     Fields:    Translation:Humans
  21. Machuca-Parra AI, Bigger-Allen AA, Sanchez AV, Boutabla A, Cardona-Vélez J, Amarnani D, Saint-Geniez M, Siebel CW, Kim LA, D'Amore PA, Arboleda-Velasquez JF. Therapeutic antibody targeting of Notch3 signaling prevents mural cell loss in CADASIL. J Exp Med. 2017 Aug 07; 214(8):2271-2282. PMID: 28698285.
    Citations: 13     Fields:    Translation:AnimalsCells
  22. Ung C, Sanchez AV, Shen L, Davoudi S, Ahmadi T, Navarro-Gomez D, Chen CJ, Hancock H, Penman A, Hoadley S, Consugar M, Restrepo C, Shah VA, Arboleda-Velasquez JF, Sobrin L, Gai X, Kim LA. Whole exome sequencing identification of novel candidate genes in patients with proliferative diabetic retinopathy. Vision Res. 2017 10; 139:168-176. PMID: 28431867.
    Citations: 9     Fields:    Translation:Humans
  23. Lam JD, Oh DJ, Wong LL, Amarnani D, Park-Windhol C, Sanchez AV, Cardona-Velez J, McGuone D, Stemmer-Rachamimov AO, Eliott D, Bielenberg DR, van Zyl T, Shen L, Gai X, D'Amore PA, Kim LA, Arboleda-Velasquez JF. Identification of RUNX1 as a Mediator of Aberrant Retinal Angiogenesis. Diabetes. 2017 07; 66(7):1950-1956. PMID: 28400392.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  24. Primo V, Graham M, Bigger-Allen AA, Chick JM, Ospina C, Quiroz YT, Manent J, Gygi SP, Lopera F, D'Amore PA, Arboleda-Velasquez JF. Blood biomarkers in a mouse model of CADASIL. Brain Res. 2016 08 01; 1644:118-26. PMID: 27174004.
    Citations: 6     Fields:    Translation:HumansAnimals
  25. Primo VA, Arboleda-Velasquez JF. Isolation and Transfection of Primary Culture Bovine Retinal Pericytes. Methods Mol Biol. 2016; 1430:107-17. PMID: 27172949.
    Citations: 1     Fields:    Translation:AnimalsCells
  26. Quiroz YT, Schultz AP, Chen K, Protas HD, Brickhouse M, Fleisher AS, Langbaum JB, Thiyyagura P, Fagan AM, Shah AR, Muniz M, Arboleda-Velasquez JF, Munoz C, Garcia G, Acosta-Baena N, Giraldo M, Tirado V, Ramírez DL, Tariot PN, Dickerson BC, Sperling RA, Lopera F, Reiman EM. Brain Imaging and Blood Biomarker Abnormalities in Children With Autosomal Dominant Alzheimer Disease: A Cross-Sectional Study. JAMA Neurol. 2015 Aug; 72(8):912-9. PMID: 26121081.
    Citations: 36     Fields:    Translation:Humans
  27. Kim LA, Wong LL, Amarnani DS, Bigger-Allen AA, Hu Y, Marko CK, Eliott D, Shah VA, McGuone D, Stemmer-Rachamimov AO, Gai X, D'Amore PA, Arboleda-Velasquez JF. Characterization of cells from patient-derived fibrovascular membranes in proliferative diabetic retinopathy. Mol Vis. 2015; 21:673-87. PMID: 26120272.
    Citations: 4     Fields:    Translation:HumansCells
  28. Arboleda-Velasquez JF, Valdez CN, Marko CK, D'Amore PA. From pathobiology to the targeting of pericytes for the treatment of diabetic retinopathy. Curr Diab Rep. 2015 Feb; 15(2):573. PMID: 25620405.
    Citations: 14     Fields:    Translation:HumansCells
  29. Valdez CN, Arboleda-Velasquez JF, Amarnani DS, Kim LA, D'Amore PA. Retinal microangiopathy in a mouse model of inducible mural cell loss. Am J Pathol. 2014 Oct; 184(10):2618-26. PMID: 25092275.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  30. Arboleda-Velasquez JF, Primo V, Graham M, James A, Manent J, D'Amore PA. Notch signaling functions in retinal pericyte survival. Invest Ophthalmol Vis Sci. 2014 Jul 11; 55(8):5191-9. PMID: 25015359.
    Citations: 13     Fields:    Translation:AnimalsCells
  31. Arboleda-Velasquez JF, Manent J, Lee JH, Tikka S, Ospina C, Vanderburg CR, Frosch MP, Rodríguez-Falcón M, Villen J, Gygi S, Lopera F, Kalimo H, Moskowitz MA, Ayata C, Louvi A, Artavanis-Tsakonas S. Hypomorphic Notch 3 alleles link Notch signaling to ischemic cerebral small-vessel disease. Proc Natl Acad Sci U S A. 2011 May 24; 108(21):E128-35. PMID: 21555590.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
  32. Brass SD, Smith EE, Arboleda-Velasquez JF, Copen WA, Frosch MP. Case records of the Massachusetts General Hospital. Case 12-2009. A 46-year-old man with migraine, aphasia, and hemiparesis and similarly affected family members. N Engl J Med. 2009 Apr 16; 360(16):1656-65. PMID: 19369672.
    Citations: 10     Fields:    Translation:Humans
  33. Arboleda-Velasquez JF, Zhou Z, Shin HK, Louvi A, Kim HH, Savitz SI, Liao JK, Salomone S, Ayata C, Moskowitz MA, Artavanis-Tsakonas S. Linking Notch signaling to ischemic stroke. Proc Natl Acad Sci U S A. 2008 Mar 25; 105(12):4856-61. PMID: 18347334.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  34. Fung E, Tang SM, Canner JP, Morishige K, Arboleda-Velasquez JF, Cardoso AA, Carlesso N, Aster JC, Aikawa M. Delta-like 4 induces notch signaling in macrophages: implications for inflammation. Circulation. 2007 Jun 12; 115(23):2948-56. PMID: 17533181.
    Citations: 84     Fields:    Translation:HumansCells
  35. Louvi A, Arboleda-Velasquez JF, Artavanis-Tsakonas S. CADASIL: a critical look at a Notch disease. Dev Neurosci. 2006; 28(1-2):5-12. PMID: 16508299.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  36. Rampal R, Arboleda-Velasquez JF, Nita-Lazar A, Kosik KS, Haltiwanger RS. Highly conserved O-fucose sites have distinct effects on Notch1 function. J Biol Chem. 2005 Sep 16; 280(37):32133-40. PMID: 15994302.
    Citations: 48     Fields:    Translation:AnimalsCells
  37. Arboleda-Velasquez JF, Rampal R, Fung E, Darland DC, Liu M, Martinez MC, Donahue CP, Navarro-Gonzalez MF, Libby P, D'Amore PA, Aikawa M, Haltiwanger RS, Kosik KS. CADASIL mutations impair Notch3 glycosylation by Fringe. Hum Mol Genet. 2005 Jun 15; 14(12):1631-9. PMID: 15857853.
    Citations: 15     Fields:    Translation:AnimalsCells
  38. Arboleda-Velasquez JF, Lopera F, Lopez E, Frosch MP, Sepulveda-Falla D, Gutierrez JE, Vargas S, Medina M, Martinez De Arrieta C, Lebo RV, Slaugenhaupt SA, Betensky RA, Villegas A, Arcos-Burgos M, Rivera D, Restrepo JC, Kosik KS. C455R notch3 mutation in a Colombian CADASIL kindred with early onset of stroke. Neurology. 2002 Jul 23; 59(2):277-9. PMID: 12136071.
    Citations: 20     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.