Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Xin Wang, Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. K01NS055072 (WANG, XIN) Mar 1, 2007 - Feb 28, 2013
    NIH/NINDS
    Identification of Novel Drugs against Huntington's Disease and Cerebral Ischemia
  2. 2013D001622 (Xin Wang)
    The ALS Therapy Alliance
  3. 254530 and 157511 (Xin Wang)
    Muscular Dystrophy Association
  4. BMGF: 01075000191 (Phase II and Phase I) (Xin Wang)
    Bill & Melinda Gates Foundation
  5. N/A (Xin Wang)
    The Hubei State Guoqiang Baojianjiu Center for Engineering and Technology Research

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Fan F, Qi J, Wang W, Liu N, Liu H, Xu X, Wang X, Tu Y, Wang W, Fu J. Amelioration of prediabetes-induced changes of dendritic structural plasticity. Front Biosci (Landmark Ed). 2019 01 01; 24:291-302. PMID: 30468656.
    Citations:    Fields:    
  2. Fan F, Qi J, Liu N, Wang Z, Wang W, Liu H, Xu X, Chen G, Wang X, Yang H, Johnson M, Tu Y, Liu T, Fu J. TGF-beta/TGF-beta RII/CLC-3 axis promotes cognitive disorders in diabetes. Front Biosci (Landmark Ed). 2019 01 01; 24:482-493. PMID: 30468668.
    Citations:    Fields:    
  3. Luo C, Yang Q, Liu Y, Zhou S, Jiang J, Reiter RJ, Bhattacharya P, Cui Y, Yang H, Ma H, Yao J, Lawler SE, Zhang X, Fu J, Rozental R, Aly H, Johnson MD, Chiocca EA, Wang X. The multiple protective roles and molecular mechanisms of melatonin and its precursor N-acetylserotonin in targeting brain injury and liver damage and in maintaining bone health. Free Radic Biol Med. 2019 01; 130:215-233. PMID: 30315933.
    Citations:    Fields:    
  4. Sarmah D, Kaur H, Saraf J, Vats K, Pravalika K, Wanve M, Kalia K, Borah A, Kumar A, Wang X, Yavagal DR, Dave KR, Bhattacharya P. Mitochondrial Dysfunction in Stroke: Implications of Stem Cell Therapy. Transl Stroke Res. 2018 Jun 20. PMID: 29926383.
    Citations:    Fields:    
  5. Wang X, Zhuang W, Fu W, Wang X, Lv E, Li F, Zhou S, Rausch WD, Wang X. The lentiviral-mediated Nurr1 genetic engineering mesenchymal stem cells protect dopaminergic neurons in a rat model of Parkinson's disease. Am J Transl Res. 2018; 10(6):1583-1599. PMID: 30018702.
    Citations:    
  6. Chen W, Sinha B, Li Y, Benowitz L, Chen Q, Zhang Z, Patel NJ, Aziz-Sultan AM, Chiocca AE, Wang X. Monogenic, Polygenic, and MicroRNA Markers for Ischemic Stroke. Mol Neurobiol. 2019 Feb; 56(2):1330-1343. PMID: 29948938.
    Citations:    Fields:    
  7. Xu X, Wang Z, Liu N, Cheng Y, Jin W, Zhang P, Wang X, Yang H, Liu H, Zhang Y, Tu Y. Association between SOX9 and CA9 in glioma, and its effects on chemosensitivity to TMZ. Int J Oncol. 2018 Jul; 53(1):189-202. PMID: 29749469.
    Citations:    Fields:    Translation:HumansCells
  8. Zhang P, Liu N, Xu X, Wang Z, Cheng Y, Jin W, Wang X, Yang H, Liu H, Zhang Y, Tu Y. Clinical significance of Iroquois Homeobox Gene - IRX1 in human glioma. Mol Med Rep. 2018 Mar; 17(3):4651-4656. PMID: 29328446.
    Citations:    Fields:    Translation:HumansCells
  9. Liu H, Yang HW, Wang X, Tu YY. Cancer Translational Medicine. The contribution of hexokinase 2 in glioma. 2018; 4(2):54-58.
  10. Yu X, Wu H, Zhao Y, Guo Y, Chen Y, Dong P, Mu Q, Wang X, Wang X. Bone marrow mesenchymal stromal cells alleviate brain white matter injury via the enhanced proliferation of oligodendrocyte progenitor cells in focal cerebral ischemic rats. Brain Res. 2018 02 01; 1680:127-136. PMID: 29258846.
    Citations: 1     Fields:    Translation:AnimalsCells
  11. Liu H, Liu N, Cheng Y, Jin W, Zhang P, Wang X, Yang H, Xu X, Wang Z, Tu Y. Hexokinase 2 (HK2), the tumor promoter in glioma, is downregulated by miR-218/Bmi1 pathway. PLoS One. 2017; 12(12):e0189353. PMID: 29220380.
    Citations:    Fields:    Translation:HumansCells
  12. Wang Z, Xu X, Liu N, Cheng Y, Jin W, Zhang P, Wang X, Yang H, Liu H, Tu Y. SOX9-PDK1 axis is essential for glioma stem cell self-renewal and temozolomide resistance. Oncotarget. 2018 Jan 02; 9(1):192-204. PMID: 29416606.
    Citations: 1     Fields:    
  13. Wu Q, Gao C, Wang H, Zhang X, Li Q, Gu Z, Shi X, Cui Y, Wang T, Chen X, Wang X, Luo C, Tao L. Mdivi-1 alleviates blood-brain barrier disruption and cell death in experimental traumatic brain injury by mitigating autophagy dysfunction and mitophagy activation. Int J Biochem Cell Biol. 2018 01; 94:44-55. PMID: 29174311.
    Citations: 2     Fields:    Translation:AnimalsCells
  14. Zhou F, Zhang C, Guan Y, Chen Y, Lu Q, Jie L, Gao H, Du H, Zhang H, Liu Y, Wang X. Screening the expression characteristics of several miRNAs in G93A-SOD1 transgenic mouse: altered expression of miRNA-124 is associated with astrocyte differentiation by targeting Sox2 and Sox9. J Neurochem. 2018 04; 145(1):51-67. PMID: 28960306.
    Citations: 2     Fields:    
  15. Sarmah D, Kaur H, Saraf J, Pravalika K, Goswami A, Kalia K, Borah A, Wang X, Dave KR, Yavagal DR, Bhattacharya P. Getting Closer to an Effective Intervention of Ischemic Stroke: The Big Promise of Stem Cell. Transl Stroke Res. 2018 08; 9(4):356-374. PMID: 29075984.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  16. Sinha B, Wu Q, Li W, Tu Y, Sirianni AC, Chen Y, Jiang J, Zhang X, Chen W, Zhou S, Reiter RJ, Manning SM, Patel NJ, Aziz-Sultan AM, Inder TE, Friedlander RM, Fu J, Wang X. Protection of melatonin in experimental models of newborn hypoxic-ischemic brain injury through MT1 receptor. J Pineal Res. 2018 Jan; 64(1). PMID: 28796402.
    Citations: 3     Fields:    Translation:AnimalsCells
  17. Chen Y, Wang Q, Wang Q, Liu H, Zhou F, Zhang Y, Yuan M, Zhao C, Guan Y, Wang X. DDX3 binding with CK1e was closely related to motor neuron degeneration of ALS by affecting neurite outgrowth. Am J Transl Res. 2017; 9(10):4627-4639. PMID: 29118923.
    Citations:    
  18. Xu XS, Yang HW, Wang X, Tu YY . Cancer Translational Medicine. The significance of nuclear factor-kappa B signaling pathway in glioma: A review. 2017; 5(3):181-184.
  19. Zhang P, Gao J, Wang X, Wen W, Yang H, Tian Y, Liu N, Wang Z, Liu H, Zhang Y, Tu Y. A novel indication of thioredoxin-interacting protein as a tumor suppressor gene in malignant glioma. Oncol Lett. 2017 Aug; 14(2):2053-2058. PMID: 28781647.
    Citations: 1     
  20. Li M, Wang Y, Wang W, Zou C, Wang X, Chen Q. Recombinant human brain-derived neurotrophic factor prevents neuronal apoptosis in a novel in vitro model of subarachnoid hemorrhage. Neuropsychiatr Dis Treat. 2017; 13:1013-1021. PMID: 28435271.
    Citations:    
  21. Liu N, Zhang L, Wang Z, Cheng Y, Zhang P, Wang X, Wen W, Yang H, Liu H, Jin W, Zhang Y, Tu Y. MicroRNA-101 inhibits proliferation, migration and invasion of human glioblastoma by targeting SOX9. Oncotarget. 2017 Mar 21; 8(12):19244-19254. PMID: 27911279.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  22. Fotinos A, Zhu YJ, Mao, LL, Zhou EW, Atassi N, Agondal S, Guan Y, Berry JD, Cudkowiz ME, Wang X . Melatonin and other neuroprotective agents target molecular mechanisms of disease in ALS. In: Melatonin, Neuroprotective agents and Antidepressant Therapy. López-Muñoz, F., Srinivasan, V., De Berardis, D., Álamo, C., Kato, T.A. (Eds.). Springer Press. 2016; 869-903. View Publication.
  23. Li M, Wang W, Mai H, Zhang X, Wang J, Gao Y, Wang Y, Deng G, Gao L, Zhou S, Chen Q, Wang X. Methazolamide improves neurological behavior by inhibition of neuron apoptosis in subarachnoid hemorrhage mice. Sci Rep. 2016 10 12; 6:35055. PMID: 27731352.
    Citations: 4     Fields:    Translation:AnimalsCells
  24. Chen D, Fu W, Zhuang W, Lv C, Li F, Wang X. Therapeutic effects of intranigral transplantation of mesenchymal stem cells in rat models of Parkinson's disease. J Neurosci Res. 2017 03; 95(3):907-917. PMID: 27617772.
    Citations: 4     Fields:    Translation:AnimalsCells
  25. Liu N, Wang Z, Cheng Y, Zhang P, Wang X, Yang H, Liu H, Zhang Y, Tu Y. Acylglycerol kinase functions as an oncogene and an unfavorable prognostic marker of human gliomas. Hum Pathol. 2016 12; 58:105-112. PMID: 27574811.
    Citations: 1     Fields:    Translation:HumansCells
  26. Qi J, Yang HW, Wang X, Tu YY. The progress in molecular biomarkers of gliomas. Cancer Translational Medicine. 2016. 2(4):125–129. 2016.
  27. Tu Y, Wang Z, Wang X, Yang H, Zhang P, Johnson M, Liu N, Liu H, Jin W, Zhang Y, Cui D. Birth of MTH1 as a therapeutic target for glioblastoma: MTH1 is indispensable for gliomatumorigenesis. Am J Transl Res. 2016; 8(6):2803-11. PMID: 27398163.
    Citations: 7     
  28. Xu W, Xu R, Li X, Zhang H, Wang X, Zhu J. Downregulating hypoxia-inducible factor-1a expression with perfluorooctyl-bromide nanoparticles reduces early brain injury following experimental subarachnoid hemorrhage in rats. Am J Transl Res. 2016; 8(5):2114-26. PMID: 27347319.
    Citations: 1     
  29. Zhang X, Wang Y, Ma C, Yan Y, Yang Y, Wang X, Rausch WD. Ginsenoside Rd and ginsenoside Re offer neuroprotection in a novel model of Parkinson's disease. Am J Neurodegener Dis. 2016; 5(1):52-61. PMID: 27073742.
    Citations: 4     
  30. Zhao YS, Wang XL, Dong P, Xu QY, Ma Z, Mu QJ, Sun XH, Jiang ZC, Wang X . Bone marrow derived mesenchymal stem cells alleviated brain injury via down-regulation of interleukin-1b in focal cerebral ischemic rats. Am J Transl Res. 2016; 8(3):1541-1550.
  31. Fan F, Liu T, Wang X, Ren D, Liu H, Zhang P, Wang Z, Liu N, Li Q, Tu Y, Fu J. ClC-3 Expression and Its Association with Hyperglycemia Induced HT22 Hippocampal Neuronal Cell Apoptosis. J Diabetes Res. 2016; 2016:2984380. PMID: 26925421.
    Citations: 1     Fields:    Translation:AnimalsCells
  32. Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze-Battaglia K, Boise LH, Bolino A, Boman A, Bonaldo P, Bordi M, Bosch J, Botana LM, Botti J, Bou G, Bouché M, Bouchecareilh M, Boucher MJ, Boulton ME, Bouret SG, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady N, Braga VM, Brancolini C, Braus GH, Bravo-San Pedro JM, Brennan LA, Bresnick EH, Brest P, Bridges D, Bringer MA, Brini M, Brito GC, Brodin B, Brookes PS, Brown EJ, Brown K, Broxmeyer HE, Bruhat A, Brum PC, Brumell JH, Brunetti-Pierri N, Bryson-Richardson RJ, Buch S, Buchan AM, Budak H, Bulavin DV, Bultman SJ, Bultynck G, Bumbasirevic V, Burelle Y, Burke RE, Burmeister M, Bütikofer P, Caberlotto L, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calatayud S, Camougrand N, Campanella M, Campbell GR, Campbell M, Campello S, Candau R, Caniggia I, Cantoni L, Cao L, Caplan AB, Caraglia M, Cardinali C, Cardoso SM, Carew JS, Carleton LA, Carlin CR, Carloni S, Carlsson SR, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carra S, Carrier A, Carroll B, Casas C, Casas J, Cassinelli G, Castets P, Castro-Obregon S, Cavallini G, Ceccherini I, Cecconi F, Cederbaum AI, Ceña V, Cenci S, Cerella C, Cervia D, Cetrullo S, Chaachouay H, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chamilos G, Chan EY, Chan MT, Chandra D, Chandra P, Chang CP, Chang RC, Chang TY, Chatham JC, Chatterjee S, Chauhan S, Che Y, Cheetham ME, Cheluvappa R, Chen CJ, Chen G, Chen GC, Chen G, Chen H, Chen JW, Chen JK, Chen M, Chen M, Chen P, Chen Q, Chen Q, Chen SD, Chen S, Chen SS, Chen W, Chen WJ, Chen WQ, Chen W, Chen X, Chen YH, Chen YG, Chen Y, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen Y, Chen Z, Chen Z, Cheng A, Cheng CH, Cheng H, Cheong H, Cherry S, Chesney J, Cheung CH, Chevet E, Chi HC, Chi SG, Chiacchiera F, Chiang HL, Chiarelli R, Chiariello M, Chieppa M, Chin LS, Chiong M, Chiu GN, Cho DH, Cho SG, Cho WC, Cho YY, Cho YS, Choi AM, Choi EJ, Choi EK, Choi J, Choi ME, Choi SI, Chou TF, Chouaib S, Choubey D, Choubey V, Chow KC, Chowdhury K, Chu CT, Chuang TH, Chun T, Chung H, Chung T, Chung YL, Chwae YJ, Cianfanelli V, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016; 12(1):1-222. PMID: 26799652.
    Citations: 867     Fields:    Translation:HumansAnimals
  33. Wang Z, Yang HW, Wang X, Wang L, Cheng YD, Zhang YS, Tu YY. The molecular mechanism and regulatory pathways of cancer stem cells. Cancer Translational Medicine. 2016; 2(5):147-153.
  34. Du R, Zhou J, Lorenzano S, Liu W, Charoenvimolphan N, Qian B, Xu J, Wang J, Zhang X, Wang X, Berndt A, Devan WJ, Valant VJ, Wang J, Furie KL, Rosand J, Rost N, Friedlander RM, Paigen B, Weiss ST. Integrative Mouse and Human Studies Implicate ANGPT1 and ZBTB7C as Susceptibility Genes to Ischemic Injury. Stroke. 2015 Dec; 46(12):3514-22. PMID: 26542693.
    Citations: 3     Fields:    Translation:HumansAnimals
  35. Yu QJ, Tao H, Wang X, Li MC. Targeting brain microvascular endothelial cells: a therapeutic approach to neuroprotection against stroke. Neural Regen Res. 2015 Nov; 10(11):1882-91. PMID: 26807131.
    Citations: 1     
  36. Chen Y, Liu H, Guan Y, Wang Q, Zhou F, Jie L, Ju J, Pu L, Du H, Wang X. The altered autophagy mediated by TFEB in animal and cell models of amyotrophic lateral sclerosis. Am J Transl Res. 2015; 7(9):1574-87. PMID: 26550457.
    Citations: 16     
  37. Wu Q, Chen W, Sinha B, Tu Y, Manning S, Thomas N, Zhou S, Jiang H, Ma H, Kroessler DA, Yao J, Li Z, Inder TE, Wang X. Neuroprotective agents for neonatal hypoxic-ischemic brain injury. Drug Discov Today. 2015 Nov; 20(11):1372-81. PMID: 26360053.
    Citations: 10     Fields:    Translation:HumansAnimals
  38. Zhang H, Xu R, Xie F, Xu W, Zeng MF, Wang X, Zhu J. Protective effects of perfluorooctyl-bromide nanoparticles on early brain injuries following subarachnoid hemorrhage in rats. Am J Transl Res. 2015; 7(8):1404-16. PMID: 26396671.
    Citations: 2     
  39. Fu W, Zhuang W, Zhou S, Wang X. Plant-derived neuroprotective agents in Parkinson's disease. Am J Transl Res. 2015; 7(7):1189-202. PMID: 26328004.
    Citations: 9     
  40. Sirianni AC, Jiang J, Zeng J, Mao LL, Zhou S, Sugarbaker P, Zhang X, Li W, Friedlander RM, Wang X. N-acetyl-l-tryptophan, but not N-acetyl-d-tryptophan, rescues neuronal cell death in models of amyotrophic lateral sclerosis. J Neurochem. 2015 Sep; 134(5):956-68. PMID: 26031348.
    Citations: 2     Fields:    Translation:AnimalsCells
  41. Li W, Fotinos A, Wu Q, Chen Y, Zhu Y, Baranov S, Tu Y, Zhou EW, Sinha B, Kristal BS, Wang X. N-acetyl-L-tryptophan delays disease onset and extends survival in an amyotrophic lateral sclerosis transgenic mouse model. Neurobiol Dis. 2015 Aug; 80:93-103. PMID: 25986728.
    Citations: 3     Fields:    Translation:AnimalsCells
  42. Xie L, Wang X, and Zhou S. Mesenchymal Stem Cells and Cartilage Regeneration in Traumatic and Osteoarthritic Cartilage Defects. Enliven: Journal of Stem Cell Research & Regenerative Medicine. 2014; 1(1):1-4. View Publication.
  43. Wang X, Guan YJ, Fu Y, Zhou S, and Qin ZH. Melatonin’s anti-apoptotic activity in Parkinson's disease, Alzheimer’s disease, Amyotrophic Lateral Sclerosis, and Huntington’s disease. Melatonin: Therapeutic Value and Neuroprotection. V Srinivasan, Gabriella Gobbi, Samuel D Shillcutt, Sibel Suzen, ed., Taylor & Francis-CRC Press. p 111-132. 2014. View Publication.
  44. Liu T, Li J, Liu H, Wang X, Fan F, Zhang P, Tu Y, Zhang Y. The coexistence of VGluT2 and neurotensin or leu-enkephalin in the medullary dorsal horn: a confocal and electron microscopic immunohistochemical study in the rat. Neurosci Lett. 2015 Jan 01; 584:390-4. PMID: 25445367.
    Citations:    Fields:    Translation:AnimalsCells
  45. Zhao X, Shen X, Chen X, Zhang J, Wang X, Zhang Y, Tu Y, Zheng G. Integrated functional neuronavigation-guided resection of small meningiomas of the atrium via the paramedian parieto-occipital approach. Clin Neurol Neurosurg. 2015 Jan; 128:47-52. PMID: 25462095.
    Citations:    Fields:    Translation:Humans
  46. Zhu Y, Fotinos A, Mao LL, Atassi N, Zhou EW, Ahmad S, Guan Y, Berry JD, Cudkowicz ME, Wang X. Neuroprotective agents target molecular mechanisms of disease in ALS. Drug Discov Today. 2015 Jan; 20(1):65-75. PMID: 25205348.
    Citations: 6     Fields:    Translation:HumansAnimals
  47. Xie F, Xu R, Song X, Zhu H, Wang X, Zhu J. Joint protective effect of exogenous neuroglobin and hemin in rat focal ischemic brain tissues. Int J Clin Exp Med. 2014; 7(8):2009-16. PMID: 25232381.
    Citations: 6     
  48. Liu H, Chen Y, Zhou F, Jie L, Pu L, Ju J, Li F, Dai Z, Wang X, Zhou S. Sox9 regulates hyperexpression of Wnt1 and Fzd1 in human osteosarcoma tissues and cells. Int J Clin Exp Pathol. 2014; 7(8):4795-805. PMID: 25197350.
    Citations: 4     Fields:    Translation:HumansCells
  49. Wang J, Dong WW, Zhang WH, Zheng J, Wang X. Electrical stimulation of cerebellar fastigial nucleus: mechanism of neuroprotection and prospects for clinical application against cerebral ischemia. CNS Neurosci Ther. 2014 Aug; 20(8):710-6. PMID: 24930936.
    Citations: 4     Fields:    Translation:HumansAnimals
  50. Jiang J, Yu S, Jiang Z, Liang C, Yu W, Li J, Du X, Wang H, Gao X, Wang X. N-acetyl-serotonin protects HepG2 cells from oxidative stress injury induced by hydrogen peroxide. Oxid Med Cell Longev. 2014; 2014:310504. PMID: 25013541.
    Citations: 6     Fields:    Translation:HumansCells
  51. Xin Wang. JSM Neurosurgery and Spine. The Antiapoptotic Effects of Melatonin in Neonatal Hypoxic-Ischemic Brain Injury and Adult Ischemic Stroke. 2014; 2(4):1033. View Publication.
  52. Wang L, Yu L, Zhang T, Wang L, Leng Z, Guan Y, Wang X. HMGB1 enhances embryonic neural stem cell proliferation by activating the MAPK signaling pathway. Biotechnol Lett. 2014 Aug; 36(8):1631-9. PMID: 24748429.
    Citations: 2     Fields:    Translation:AnimalsCells
  53. Song X, Xu R, Xie F, Zhu H, Zhu J, Wang X. Hemin offers neuroprotection through inducing exogenous neuroglobin in focal cerebral hypoxic-ischemia in rats. Int J Clin Exp Pathol. 2014; 7(5):2163-71. PMID: 24966924.
    Citations: 7     Fields:    Translation:Animals
  54. Wang X, Zhao Y, Wang X. Umbilical cord blood cells regulate the differentiation of endogenous neural stem cells in hypoxic ischemic neonatal rats via the hedgehog signaling pathway. Brain Res. 2014 Apr 29; 1560:18-26. PMID: 24565927.
    Citations: 5     Fields:    Translation:AnimalsCells
  55. Zhou H, Wang J, Jiang J, Stavrovskaya IG, Li M, Li W, Wu Q, Zhang X, Luo C, Zhou S, Sirianni AC, Sarkar S, Kristal BS, Friedlander RM, Wang X. N-acetyl-serotonin offers neuroprotection through inhibiting mitochondrial death pathways and autophagic activation in experimental models of ischemic injury. J Neurosci. 2014 Feb 19; 34(8):2967-78. PMID: 24553937.
    Citations: 19     Fields:    Translation:AnimalsCells
  56. Yu S, Zheng J, Jiang Z, Shi C, Li J, Du X, Wang H, Jiang J, Wang X. Protective effect of N-acetylserotonin against acute hepatic ischemia-reperfusion injury in mice. Int J Mol Sci. 2013 Aug 29; 14(9):17680-93. PMID: 23994834.
    Citations: 4     Fields:    Translation:Animals
  57. Zhou F, Guan Y, Chen Y, Zhang C, Yu L, Gao H, Du H, Liu B, Wang X. miRNA-9 expression is upregulated in the spinal cord of G93A-SOD1 transgenic mice. Int J Clin Exp Pathol. 2013; 6(9):1826-38. PMID: 24040447.
    Citations: 12     Fields:    Translation:AnimalsCells
  58. Fu W, Zheng Z, Zhuang W, Chen D, Wang X, Sun X, Wang X. Neural metabolite changes in corpus striatum after rat multipotent mesenchymal stem cells transplanted in hemiparkinsonian rats by magnetic resonance spectroscopy. Int J Neurosci. 2013 Dec; 123(12):883-91. PMID: 23768098.
    Citations: 3     Fields:    Translation:AnimalsCells
  59. Pandya RS, Zhu H, Li W, Bowser R, Friedlander RM, Wang X. Therapeutic neuroprotective agents for amyotrophic lateral sclerosis. Cell Mol Life Sci. 2013 Dec; 70(24):4729-45. PMID: 23864030.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  60. Yu L, Guan Y, Wu X, Chen Y, Liu Z, Du H, Wang X. Wnt Signaling is altered by spinal cord neuronal dysfunction in amyotrophic lateral sclerosis transgenic mice. Neurochem Res. 2013 Sep; 38(9):1904-13. PMID: 23784673.
    Citations: 11     Fields:    Translation:AnimalsCells
  61. Li X, Guan Y, Chen Y, Zhang C, Shi C, Zhou F, Yu L, Juan J, Wang X. Expression of Wnt5a and its receptor Fzd2 is changed in the spinal cord of adult amyotrophic lateral sclerosis transgenic mice. Int J Clin Exp Pathol. 2013; 6(7):1245-60. PMID: 23826406.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  62. Wang S, Guan Y, Chen Y, Li X, Zhang C, Yu L, Zhou F, Wang X. Role of Wnt1 and Fzd1 in the spinal cord pathogenesis of amyotrophic lateral sclerosis-transgenic mice. Biotechnol Lett. 2013 Aug; 35(8):1199-207. PMID: 23553522.
    Citations: 10     Fields:    Translation:AnimalsCells
  63. Zhang Y, Cook A, Kim J, Baranov SV, Jiang J, Smith K, Cormier K, Bennett E, Browser RP, Day AL, Carlisle DL, Ferrante RJ, Wang X, Friedlander RM. Melatonin inhibits the caspase-1/cytochrome c/caspase-3 cell death pathway, inhibits MT1 receptor loss and delays disease progression in a mouse model of amyotrophic lateral sclerosis. Neurobiol Dis. 2013 Jul; 55:26-35. PMID: 23537713.
    Citations: 19     Fields:    Translation:AnimalsCells
  64. Du R, Zhou J, Lorenzano S, Charoenvimolphan N, Qian B, Rost N, Wang J, Zhang XM, Wang X, Berndt A, Devan WJ, Valant VJ, Furie KL, Rosand J, Friedlander R, Paigen B, Weiss ST. ZBTB7C Is Associated With Severity Of Infarction In Cerebral Ischemia. Stroke. 2013; 44:AWP258.
  65. Ma H, Sinha B, Pandya RS, Lin N, Popp AJ, Li J, Yao J, Wang X. Therapeutic hypothermia as a neuroprotective strategy in neonatal hypoxic-ischemic brain injury and traumatic brain injury. Curr Mol Med. 2012 Dec; 12(10):1282-96. PMID: 22834830.
    Citations: 11     Fields:    Translation:Humans
  66. Chen Y, Guan Y, Zhang Z, Liu H, Wang S, Yu L, Wu X, Wang X. Wnt signaling pathway is involved in the pathogenesis of amyotrophic lateral sclerosis in adult transgenic mice. Neurol Res. 2012 May; 34(4):390-9. PMID: 22643084.
    Citations: 17     Fields:    Translation:AnimalsCells
  67. Chen Y, Guan Y, Liu H, Wu X, Yu L, Wang S, Zhao C, Du H, Wang X. Activation of the Wnt/ß-catenin signaling pathway is associated with glial proliferation in the adult spinal cord of ALS transgenic mice. Biochem Biophys Res Commun. 2012 Apr 06; 420(2):397-403. PMID: 22426476.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  68. Pandya RS, Mao LL, Zhou EW, Bowser R, Zhu Z, Zhu Y, Wang X. Neuroprotection for amyotrophic lateral sclerosis: role of stem cells, growth factors, and gene therapy. Cent Nerv Syst Agents Med Chem. 2012 Mar; 12(1):15-27. PMID: 22283698.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  69. Lv L, Han X, Sun Y, Wang X, Dong Q. Valproic acid improves locomotion in vivo after SCI and axonal growth of neurons in vitro. Exp Neurol. 2012 Feb; 233(2):783-90. PMID: 22178331.
    Citations: 23     Fields:    Translation:AnimalsCells
  70. Wang X, Sirianni A, Pei Z, Cormier K, Smith K, Jiang J, Zhou S, Wang H, Zhao R, Yano H, Kim JE, Li W, Kristal BS, Ferrante RJ, Friedlander RM. The melatonin MT1 receptor axis modulates mutant Huntingtin-mediated toxicity. J Neurosci. 2011 Oct 12; 31(41):14496-507. PMID: 21994366.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  71. Zhang Y, Wang X, Baranov SV, Zhu S, Huang Z, Fellows-Mayle W, Jiang J, Day AL, Kristal BS, Friedlander RM. Dipyrone inhibits neuronal cell death and diminishes hypoxic/ischemic brain injury. Neurosurgery. 2011 Oct; 69(4):942-56. PMID: 21552169.
    Citations: 12     Fields:    Translation:AnimalsCells
  72. Lv L, Tang YP, Han X, Wang X, Dong Q. Therapeutic application of histone deacetylase inhibitors for stroke. Cent Nerv Syst Agents Med Chem. 2011 Jun 01; 11(2):138-49. PMID: 21521169.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  73. Wang X. Recent advances in stroke: molecular mechanisms, approaches, and treatments. Cent Nerv Syst Agents Med Chem. 2011 Jun 01; 11(2):80. PMID: 21521173.
    Citations: 2     Fields:    Translation:Humans
  74. Pandya RS, Mao L, Zhou H, Zhou S, Zeng J, Popp AJ, Wang X. Central nervous system agents for ischemic stroke: neuroprotection mechanisms. Cent Nerv Syst Agents Med Chem. 2011 Jun 01; 11(2):81-97. PMID: 21521165.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  75. Sinha B, Yano, H, Li, W, Wang, X, Friedlander RM. Pediatric Research. Receptor inducing protein-2 (Rip2) deficiency is neuroprotective against hypoxia-ischemic brain injury in newborn mice. 2011; 70(5):66.
  76. Wang X, Pandya R, Yao J, Ma H, Li J. Targeting caspases in neonatal hypoxia-ischemic brain injury and traumatic brain injury. Neurodegeneration: Theory, Disorders and Treatments. A. S. McNeill, Ed., NOVA Science Publishers, Inc. New York p. 125-154. 2010. View Publication.
  77. Wang X. The antiapoptotic activity of melatonin in neurodegenerative diseases. CNS Neurosci Ther. 2009; 15(4):345-57. PMID: 19818070.
    Citations: 39     Fields:    Translation:HumansAnimals
  78. Wang X, Figueroa BE, Stavrovskaya IG, Zhang Y, Sirianni AC, Zhu S, Day AL, Kristal BS, Friedlander RM. Methazolamide and melatonin inhibit mitochondrial cytochrome C release and are neuroprotective in experimental models of ischemic injury. Stroke. 2009 May; 40(5):1877-85. PMID: 19299628.
    Citations: 37     Fields:    Translation:AnimalsCells
  79. Yu L, Guan YJ, Gao Y, Wang X. Rpl30 and Hmgb1 are required for neurulation in golden hamster. Int J Neurosci. 2009; 119(8):1076-90. PMID: 19922340.
    Citations:    Fields:    Translation:AnimalsCells
  80. Wang X, Zhu S, Pei Z, Drozda M, Stavrovskaya IG, Del Signore SJ, Cormier K, Shimony EM, Wang H, Ferrante RJ, Kristal BS, Friedlander RM. Inhibitors of cytochrome c release with therapeutic potential for Huntington's disease. J Neurosci. 2008 Sep 17; 28(38):9473-85. PMID: 18799679.
    Citations: 35     Fields:    Translation:AnimalsCells
  81. Zhang WH, Wang H, Wang X, Narayanan MV, Stavrovskaya IG, Kristal BS, Friedlander RM. Nortriptyline protects mitochondria and reduces cerebral ischemia/hypoxia injury. Stroke. 2008 Feb; 39(2):455-62. PMID: 18174477.
    Citations: 21     Fields:    Translation:AnimalsCells
  82. Wang H, Guan Y, Wang X, Smith K, Cormier K, Zhu S, Stavrovskaya IG, Huo C, Ferrante RJ, Kristal BS, Friedlander RM. Nortriptyline delays disease onset in models of chronic neurodegeneration. Eur J Neurosci. 2007 Aug; 26(3):633-41. PMID: 17686041.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  83. Guan YJ, Wang X, Wang HY, Kawagishi K, Ryu H, Huo CF, Shimony EM, Kristal BS, Kuhn HG, Friedlander RM. Increased stem cell proliferation in the spinal cord of adult amyotrophic lateral sclerosis transgenic mice. J Neurochem. 2007 Aug; 102(4):1125-38. PMID: 17472707.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  84. Zhang XW, Li RG, Wang X, Zhou SH. Effects of copper-phenanthroline on pentachlorophenol-induced adaptation and cell death of Escherichia coli. Biomed Environ Sci. 2007 Apr; 20(2):106-12. PMID: 17624183.
    Citations: 1     Fields:    Translation:Cells
  85. Frusic-Zlotkin M, Raichenberg D, Wang X, David M, Michel B, Milner Y. Apoptotic mechanism in pemphigus autoimmunoglobulins-induced acantholysis--possible involvement of the EGF receptor. Autoimmunity. 2006 Nov; 39(7):563-75. PMID: 17101500.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  86. Y. Guan, X. Wang, H. Wang, K. Kawagishi, C. Huo, E. Shimony, B. Kristal, H. Kuhn, R. M. Friedlander. Brigham & Women's Hosp, Boston, MA. Increased stem cell proliferation in the spinal cord of adult ALS transgenic mice . Neuroscience 2006, Society for Neuroscience, Press Book Part 2. 2006; 175-6.
  87. Wang X, Narayanan M, Bruey JM, Rigamonti D, Cattaneo E, Reed JC, Friedlander RM. Protective role of Cop in Rip2/caspase-1/caspase-4-mediated HeLa cell death. Biochim Biophys Acta. 2006 Aug; 1762(8):742-54. PMID: 16920334.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  88. Frusic-Zlotkin M, Raichenberg D, Michel B, Wang X, Milner Y. Signaling elicited by pemphigus (PV)-IgG in cultured epidermal cells: involvement of EGFR and MAPK cascades. Journal of Investigative Dermatology. 2006; 126(1):8. View Publication.
  89. Wang X, Wang H, Figueroa BE, Zhang WH, Huo C, Guan Y, Zhang Y, Bruey JM, Reed JC, Friedlander RM. Dysregulation of receptor interacting protein-2 and caspase recruitment domain only protein mediates aberrant caspase-1 activation in Huntington's disease. J Neurosci. 2005 Dec 14; 25(50):11645-54. PMID: 16354923.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  90. Wang X, Brégégère F, Soroka Y, Frusic-Zlotkin M, Milner Y. Replicative senescence enhances apoptosis induced by pemphigus autoimmune antibodies in human keratinocytes. FEBS Lett. 2004 Jun 04; 567(2-3):281-6. PMID: 15178337.
    Citations: 8     Fields:    Translation:HumansCells
  91. Wang X, Brégégère F, Soroka Y, Kayat A, Redziniak G, Milner Y. Enhancement of Fas-mediated apoptosis in ageing human keratinocytes. Mech Ageing Dev. 2004 Mar; 125(3):237-49. PMID: 15013668.
    Citations: 2     Fields:    Translation:HumansCells
  92. Wang X, Brégégère F, Frusic-Zlotkin M, Feinmesser M, Michel B, Milner Y. Possible apoptotic mechanism in epidermal cell acantholysis induced by pemphigus vulgaris autoimmunoglobulins. Apoptosis. 2004 Mar; 9(2):131-43. PMID: 15004510.
    Citations: 21     Fields:    Translation:HumansCells
  93. Zhang WH, Wang X, Narayanan M, Zhang Y, Huo C, Reed JC, Friedlander RM. Fundamental role of the Rip2/caspase-1 pathway in hypoxia and ischemia-induced neuronal cell death. Proc Natl Acad Sci U S A. 2003 Dec 23; 100(26):16012-7. PMID: 14663141.
    Citations: 54     Fields:    Translation:AnimalsCells
  94. Wang X, Zhu S, Drozda M, Zhang W, Stavrovskaya IG, Cattaneo E, Ferrante RJ, Kristal BS, Friedlander RM. Minocycline inhibits caspase-independent and -dependent mitochondrial cell death pathways in models of Huntington's disease. Proc Natl Acad Sci U S A. 2003 Sep 02; 100(18):10483-7. PMID: 12930891.
    Citations: 108     Fields:    Translation:HumansAnimalsCells
  95. Wang X, Shao Z, Zetoune FS, Zeidler MG, Gowrishankar K, Vincenz C. NRADD, a novel membrane protein with a death domain involved in mediating apoptosis in response to ER stress. Cell Death Differ. 2003 May; 10(5):580-91. PMID: 12728256.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  96. Frusic-Zlotkin M, Wang X, Brégégère F, Michel B and Milner Y. Pemphigus vulgaris IgG-induced acantholysis in organ and cell culture: Kinetics of appearance of apoptotic effectors. Journal of Investigative Dermatology . 2003; 121(1):0100.
  97. Frusic-Zlotkin M, Goldshmit D, Wang X, David M, Maron L, Michel B, Milner Y. Pathogenicity test of pemphigus vulgaris autoantibodies: Use of enzymatic activity of the apoptotic caspase 3. Journal of Investigative Dermatology. 2002; 119(1):Part 2, 325. View Publication.
  98. Wang X, Bauer JH, Li Y, Shao Z, Zetoune FS, Cattaneo E, Vincenz C. Characterization of a p75(NTR) apoptotic signaling pathway using a novel cellular model. J Biol Chem. 2001 Sep 07; 276(36):33812-20. PMID: 11451944.
    Citations: 31     Fields:    Translation:HumansCells
  99. Guo RF, Huber-Lang M, Wang X, Sarma V, Padgaonkar VA, Craig RA, Riedemann NC, McClintock SD, Hlaing T, Shi MM, Ward PA. Protective effects of anti-C5a in sepsis-induced thymocyte apoptosis. J Clin Invest. 2000 Nov; 106(10):1271-80. PMID: 11086028.
    Citations: 41     Fields:    Translation:AnimalsCells
  100. Petropoulos I, Conconi M, Wang X, Hoenel B, Brégégère F, Milner Y, Friguet B. Increase of oxidatively modified protein is associated with a decrease of proteasome activity and content in aging epidermal cells. J Gerontol A Biol Sci Med Sci. 2000 May; 55(5):B220-7. PMID: 10819308.
    Citations: 28     Fields:    Translation:HumansCells
  101. Wang X, Bregegere F, Frusic-Zlotkin M, Michel B, Milner Y . The similarity between PV-IgG and anti-FAS receptor IgG (FAS-IgG) in induction of cultured keratinocytes apoptosis. Journal of Investigative Dermatology. 1999; 112(4):623. View Publication.
  102. Milner Y, Merau P, Kiefer H, Feinmesser M, Bregegere F, Zlotkin M, Wang X, Michel B. Pemphigus, an autoimmune disease of the skin: cell-cell separation versus membranal signaling and apoptosis in acantholysis. In: The Decade of Autoimmunity, Y. Schoenfeld, ed., Elsevier Science. 1999; 197-207. View Publication.
  103. Wang X, Bregegere F, Goldshmit D, and Milner Y. The autoimmune pemphigus vulgaris-IgG (PV-IgG), similar to anti Fas receptor IgG (Fas-IgG), induces changes in signaling effectors leading to apoptosis of epidermal cells. Journal of Autoimmunity . 1999; 12:65.
  104. Wang X, Bregegere F, Frusic-Zlotkin M, Michel B and Milner Y. The similarity between auto-immune PV-IgG and anti-Fas receptor IgG (FAS-IgG) in induction of cultured keratinocytes apoptosis. Journal of Investigative Dermatology. 1999; 112(4):602.
  105. Frankenburg S, Wang X, Milner Y. Vitamin A inhibits cytokines produced by type 1 lymphocytes in vitro. Cell Immunol. 1998 Apr 10; 185(1):75-81. PMID: 9636685.
    Citations: 5     Fields:    Translation:AnimalsCells
  106. Wang X, Redziniak G, Bregegere F, Milner, Y. Aged keratinocytes display increased levels of apoptosis-associated proteins, and increased susceptibility to apoptosis induction. Journal of Investigative Dermatology. 1998; 104(4):555. View Publication.
  107. Wang X, Bregegere F, Feinmesser M, Michel B, Milner Y. Pemphigus-IgG (PV IgG) induces apoptosis in lesional skin and in cell and organ cultures. Journal of Investigative Dermatology. 1998; 110(4):513. View Publication.
  108. Zhou S and Wang X. The correlation of bond-parameter and topological index of lattice enthalpy. Chemical Research and Application. 1992; 4:48-52. View Publication.
  109. Wang X, Zhou S, Qian Y and Chen Z. The research of phase and conductivity of Ba-La-Cu-O, Ba2xSrxLaCu3O7-d, Ba2La1xCexCu3O7-delta systems. Bulletin of the Chinese Ceramic Society. 1991; 10:12-17. View Publication.
  110. Zhou S, Wang X and Nie S. The electrode potentials and atomic sotentiols scale of the hardness- softness of acids and bases. Chemical Research and Application. 1990; 2:88-93.
  111. Xin Wang et al., All Subjects Dictionary, Xioushong Li Ed., Anhui People Publishing House, Hefei. 1990.
  112. Gao C, Wang X, Cheng T, Liu Y, Liu W, Qian Y and Chen Z. Structure study of Ba2CeCu3O7.4 Solid State Communication. 1989; 70:631-635. View Publication.
  113. Wang X, Qian Y, Chen Z, Wen Y and Zhang, Q. The synthesis, conductivity of Li-Ti- Cu-O system composite oxide compound. Guisuanyan Tongbao. 1989; 8:11-15.
  114. Wang X, Qian Y, Chen Z, Cheng T, Wen Y and Zhang Q. The crystal structure, conductivity and phase of Ba2CeCu3O7-detla composite oxide compound. Rare Earth. 1989; 1:1-5.
  115. Xin Wang, et al. The Chinese Encyclopedia Dictionary, "Hua xue" GuangYuan Yu, Ed. Huaxia Publishing House, Beijing . 1989. View Publication.
  116. Qian Y, Wang X, Chen Z, Wen Y, sheng J, Fang M, Sun S, and Zhang Q. Phase situation of superconductivity of Ba-Y-Cu-O doped with K+ and Li+. Bulletin of Chinese Sillicate Society. 1988; 7:19-23.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.