Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Donald Craig Simonson, S.D., M.D.

Other Positions

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01DK043505 (SIMONSON, DONALD C) Aug 1, 1991 - Jul 31, 1996
    Role: Principal Investigator
  2. M01RR002635 (GOTTLIEB, GARY L) Dec 1, 1984 - Mar 31, 2010
    General Clinical Research Center
    Role: Co-Principal Investigator
  3. K01AG000233 (SIMONSON, DONALD C) Aug 1, 1983 - Dec 31, 1988
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. McDonnell ME, Garg R, Gopalakrishnan G, Mitri J, Weinstock RS, Greenfield M, Katta S, Lebastchi J, Palermo NE, Radhakrishnan R, Westcott GP, Johnson M, Simonson DC. Glycemic Gap Predicts Mortality in a Large Multicenter Cohort Hospitalized with COVID-19. J Clin Endocrinol Metab. 2022 Oct 11. PMID: 36217580; PMCID: PMC9619706.
    Citations:    Fields:    
  2. Kirwan JP, Courcoulas AP, Cummings DE, Goldfine AB, Kashyap SR, Simonson DC, Arterburn DE, Gourash WF, Vernon AH, Jakicic JM, Patti ME, Wolski K, Schauer PR. Diabetes Remission in the Alliance of Randomized Trials of Medicine Versus Metabolic Surgery in Type 2 Diabetes (ARMMS-T2D). Diabetes Care. 2022 07 07; 45(7):1574-1583. PMID: 35320365; PMCID: PMC9490448.
    Citations:    Fields:    Translation:Humans
  3. Bolo NR, Jacobson AM, Musen G, Simonson DC. Hyperglycemia and hyperinsulinemia effects on anterior cingulate cortex myoinositol-relation to brain network functional connectivity in healthy adults. J Neurophysiol. 2022 05 01; 127(5):1426-1437. PMID: 35417272; PMCID: PMC9109787.
    Citations:    Fields:    Translation:Humans
  4. Simonson DC, Hu B, Arterburn DE, Schauer PR, Kashyap SR, Courcoulas AP, Cummings DE, Patti ME, Gourash WF, Vernon AH, Jakicic JM, Kirwan JP. Alliance of Randomized Trials of Medicine vs Metabolic Surgery in Type 2 Diabetes (ARMMS-T2D): Study rationale, design, and methods. Diabetes Obes Metab. 2022 07; 24(7):1206-1215. PMID: 35233923; PMCID: PMC9177689.
    Citations:    Fields:    Translation:Humans
  5. Dreyfuss JM, Yuchi Y, Dong X, Efthymiou V, Pan H, Simonson DC, Vernon A, Halperin F, Aryal P, Konkar A, Sebastian Y, Higgs BW, Grimsby J, Rondinone CM, Kasif S, Kahn BB, Foster K, Seeley R, Goldfine A, Djordjilovic V, Patti ME. High-throughput mediation analysis of human proteome and metabolome identifies mediators of post-bariatric surgical diabetes control. Nat Commun. 2021 11 29; 12(1):6951. PMID: 34845204; PMCID: PMC8630169.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  6. Cromwell GE, Hudson MS, Simonson DC, McDonnell ME. Outreach Method Predicts Patient Re-engagement in Diabetes Care During Sustained Care Disruption. Endocr Pract. 2022 Jan; 28(1):2-7. PMID: 34534679; PMCID: PMC8438798.
    Citations:    Fields:    Translation:HumansPHPublic Health
  7. Bolo NR, Jacobson AM, Musen G, Keshavan MS, Simonson DC. Acute Hyperglycemia Increases Brain Pregenual Anterior Cingulate Cortex Glutamate Concentrations in Type 1 Diabetes. Diabetes. 2020 07; 69(7):1528-1539. PMID: 32295804; PMCID: PMC7306132.
    Citations: 3     Fields:    Translation:HumansCells
  8. Frias JP, Gonzalez-Galvez G, Johnsson E, Maaske J, Testa MA, Simonson DC, Dronamraju N, Garcia-Sanchez R, Peters AL. Efficacy and safety of dual add-on therapy with dapagliflozin plus saxagliptin versus glimepiride in patients with poorly controlled type 2 diabetes on a stable dose of metformin: Results from a 52-week, randomized, active-controlled trial. Diabetes Obes Metab. 2020 07; 22(7):1083-1093. PMID: 32052516.
    Citations: 3     Fields:    Translation:Humans
  9. Zhang H, Goldberg SI, Hosomura N, Shubina M, Simonson DC, Testa MA, Turchin A. Lifestyle Counseling and Long-term Clinical Outcomes in Patients With Diabetes. Diabetes Care. 2019 09; 42(9):1833-1836. PMID: 31371430.
    Citations: 1     Fields:    Translation:Humans
  10. Simonson DC, Vernon A, Foster K, Halperin F, Patti ME, Goldfine AB. Adjustable gastric band surgery or medical management in patients with type 2 diabetes and obesity: three-year results of a randomized trial. Surg Obes Relat Dis. 2019 Dec; 15(12):2052-2059. PMID: 31931977.
    Citations: 4     Fields:    Translation:Humans
  11. Blair RA, Palermo NE, Modzelewski KL, Alexanian SM, Baker WE, Simonson DC, McDonnell ME. REDUCED IMPACT OF DIABETES CLINIC REFERRAL ON HIGH-FREQUENCY EMERGENCY DEPARTMENT USERS. Endocr Pract. 2018 Dec; 24(12):1043-1050. PMID: 30289310.
    Citations: 1     Fields:    Translation:Humans
  12. Turchin A, Sosina O, Zhang H, Shubina M, Desai SP, Simonson DC, Testa MA. Ambulatory Medication Reconciliation and Frequency of Hospitalizations and Emergency Department Visits in Patients With Diabetes. Diabetes Care. 2018 08; 41(8):1639-1645. PMID: 29891639.
    Citations: 1     Fields:    Translation:HumansPHPublic Health
  13. Simonson DC, Halperin F, Foster K, Vernon A, Goldfine AB. Clinical and Patient-Centered Outcomes in Obese Patients With Type 2 Diabetes 3 Years After Randomization to Roux-en-Y Gastric Bypass Surgery Versus Intensive Lifestyle Management: The SLIMM-T2D Study. Diabetes Care. 2018 04; 41(4):670-679. PMID: 29432125.
    Citations: 21     Fields:    Translation:Humans
  14. Yoon S, Kim J, Musen G, Renshaw PF, Hwang J, Bolo NR, Kim JE, Simonson DC, Weinger K, Ryan CM, Lyoo IK, Jacobson AM. Prefronto-temporal white matter microstructural alterations 20?years after the diagnosis of type 1 diabetes mellitus. Pediatr Diabetes. 2018 05; 19(3):478-485. PMID: 28929564.
    Citations: 5     Fields:    Translation:Humans
  15. Machytka E, Bužga M, Zonca P, Lautz DB, Ryou M, Simonson DC, Thompson CC. Partial jejunal diversion using an incisionless magnetic anastomosis system: 1-year interim results in patients with obesity and diabetes. Gastrointest Endosc. 2017 Nov; 86(5):904-912. PMID: 28716404.
    Citations: 32     Fields:    Translation:Humans
  16. Yoon S, Cho H, Kim J, Lee DW, Kim GH, Hong YS, Moon S, Park S, Lee S, Lee S, Bae S, Simonson DC, Lyoo IK. Brain changes in overweight/obese and normal-weight adults with type 2 diabetes mellitus. Diabetologia. 2017 07; 60(7):1207-1217. PMID: 28447116.
    Citations: 12     Fields:    Translation:Humans
  17. Ramada Faria GF, Nunes Santos JM, Simonson DC. Quality of life after gastric sleeve and gastric bypass for morbid obesity. Porto Biomed J. 2017 Mar-Apr; 2(2):40-46. PMID: 32258584; PMCID: PMC6806970.
    Citations: 2     
  18. Palermo NE, Modzelewski KL, Farwell AP, Fosbroke J, Shankar KN, Alexanian SM, Baker WE, Simonson DC, McDonnell ME. OPEN ACCESS TO DIABETES CENTER FROM THE EMERGENCY DEPARTMENT REDUCES HOSPITALIZATIONS IN THE SUSEQUENT YEAR. Endocr Pract. 2016 Oct; 22(10):1161-1169. PMID: 27732094.
    Citations: 4     Fields:    Translation:Humans
  19. Panosian J, Ding SA, Wewalka M, Simonson DC, Goebel-Fabbri A, Foster K, Halperin F, Vernon A, Goldfine AB. Physical Activity in Obese Type 2 Diabetes After Gastric Bypass or Medical Management. Am J Med. 2017 Jan; 130(1):83-92. PMID: 27555097; PMCID: PMC5164867.
    Citations: 9     Fields:    Translation:Humans
  20. Palermo NE, Modzelewski KL, Farwell AP, Fosbroke J, Shankar KN, Alexanian SM, Baker WE, Simonson DC, McDonnell ME. OPEN ACCESS TO DIABETES CENTER FROM THE EMERGENCY DEPARTMENT REDUCES HOSPITALIZATIONS IN THE SUBSEQUENT YEAR. Endocr Pract. 2016 Jun 13. PMID: 27295016.
  21. Yu EW, Wewalka M, Ding SA, Simonson DC, Foster K, Holst JJ, Vernon A, Goldfine AB, Halperin F. Effects of Gastric Bypass and Gastric Banding on Bone Remodeling in Obese Patients With Type 2 Diabetes. J Clin Endocrinol Metab. 2016 Feb; 101(2):714-22. PMID: 26600045; PMCID: PMC4880129.
    Citations: 27     Fields:    Translation:HumansCTClinical Trials
  22. Bolo NR, Musen G, Simonson DC, Nickerson LD, Flores VL, Siracusa T, Hager B, Lyoo IK, Renshaw PF, Jacobson AM. Functional Connectivity of Insula, Basal Ganglia, and Prefrontal Executive Control Networks during Hypoglycemia in Type 1 Diabetes. J Neurosci. 2015 Aug 05; 35(31):11012-23. PMID: 26245963; PMCID: PMC4524972.
    Citations: 23     Fields:    Translation:Humans
  23. DeFronzo RA, Ferrannini E, Groop L, Henry RR, Herman WH, Holst JJ, Hu FB, Kahn CR, Raz I, Shulman GI, Simonson DC, Testa MA, Weiss R. Type 2 diabetes mellitus. Nat Rev Dis Primers. 2015 07 23; 1:15019. PMID: 27189025.
    Citations: 350     Fields:    Translation:HumansCells
  24. Ding SA, Simonson DC, Wewalka M, Halperin F, Foster K, Goebel-Fabbri A, Hamdy O, Clancy K, Lautz D, Vernon A, Goldfine AB. Adjustable Gastric Band Surgery or Medical Management in Patients With Type 2 Diabetes: A Randomized Clinical Trial. J Clin Endocrinol Metab. 2015 Jul; 100(7):2546-56. PMID: 25909333; PMCID: PMC4490302.
    Citations: 31     Fields:    Translation:Humans
  25. Simonson DC. Surrogate measures of insulin resistance: does one size fit all? Diabetologia. 2015 Feb; 58(2):207-10. PMID: 25413048.
    Citations: 4     Fields:    Translation:Humans
  26. Okafor PN, Lien C, Bairdain S, Simonson DC, Halperin F, Vernon AH, Linden BC, Lautz DB. Effect of vagotomy during Roux-en-Y gastric bypass surgery on weight loss outcomes. Obes Res Clin Pract. 2015 May-Jun; 9(3):274-80. PMID: 25458372.
    Citations: 11     Fields:    Translation:Humans
  27. Halperin F, Ding SA, Simonson DC, Panosian J, Goebel-Fabbri A, Wewalka M, Hamdy O, Abrahamson M, Clancy K, Foster K, Lautz D, Vernon A, Goldfine AB. Roux-en-Y gastric bypass surgery or lifestyle with intensive medical management in patients with type 2 diabetes: feasibility and 1-year results of a randomized clinical trial. JAMA Surg. 2014 Jul; 149(7):716-26. PMID: 24899464; PMCID: PMC4274782.
    Citations: 88     Fields:    Translation:Humans
  28. Marder TJ, Flores VL, Bolo NR, Hoogenboom WS, Simonson DC, Jacobson AM, Foote SE, Shenton ME, Sperling RA, Musen G. Task-induced brain activity patterns in type 2 diabetes: a potential biomarker for cognitive decline. Diabetes. 2014 Sep; 63(9):3112-9. PMID: 24705405; PMCID: PMC4141362.
    Citations: 17     Fields:    Translation:Humans
  29. Bairdain S, Lien C, Stoffan AP, Troy M, Simonson DC, Linden BC. A Single Institution's Overweight Pediatric Population and Their Associated Comorbid Conditions. ISRN Obes. 2014; 2014:517694. PMID: 24693463.
  30. Taveira TH, Wu WC, Tschibelu E, Borsook D, Simonson DC, Yamamoto R, Langleben DD, Swift R, Elman I. The effect of naltrexone on body fat mass in olanzapine-treated schizophrenic or schizoaffective patients: a randomized double-blind placebo-controlled pilot study. J Psychopharmacol. 2014 Apr; 28(4):395-400. PMID: 24218048.
    Citations: 11     Fields:    Translation:Humans
  31. Hoogenboom WS, Marder TJ, Flores VL, Huisman S, Eaton HP, Schneiderman JS, Bolo NR, Simonson DC, Jacobson AM, Kubicki M, Shenton ME, Musen G. Cerebral white matter integrity and resting-state functional connectivity in middle-aged patients with type 2 diabetes. Diabetes. 2014 Feb; 63(2):728-38. PMID: 24203723; PMCID: PMC3900542.
    Citations: 69     Fields:    Translation:Humans
  32. Lyoo IK, Yoon S, Renshaw PF, Hwang J, Bae S, Musen G, Kim JE, Bolo N, Jeong HS, Simonson DC, Lee SH, Weinger K, Jung JJ, Ryan CM, Choi Y, Jacobson AM. Network-level structural abnormalities of cerebral cortex in type 1 diabetes mellitus. PLoS One. 2013; 8(8):e71304. PMID: 24058401.
    Citations: 7     Fields:    Translation:Humans
  33. Trikudanathan S, Raji A, Chamarthi B, Seely EW, Simonson DC. Comparison of insulin sensitivity measures in South Asians. Metabolism. 2013 Oct; 62(10):1448-54. PMID: 23906497; PMCID: PMC3889665.
    Citations: 3     Fields:    Translation:Humans
  34. Lyoo IK, Yoon S, Jacobson AM, Hwang J, Musen G, Kim JE, Simonson DC, Bae S, Bolo N, Kim DJ, Weinger K, Lee JH, Ryan CM, Renshaw PF. Prefrontal cortical deficits in type 1 diabetes mellitus: brain correlates of comorbid depression. Arch Gen Psychiatry. 2012 Dec; 69(12):1267-76. PMID: 23090665.
    Citations: 15     Fields:    
  35. Zuo CS, Sung YH, Simonson DC, Habecker E, Wang J, Haws C, Villafuerte RA, Henry ME, Dobbins RL, Hodge RJ, Nunez DJ, Renshaw PF. Reduced T2* values in soleus muscle of patients with type 2 diabetes mellitus. PLoS One. 2012; 7(11):e49337. PMID: 23189142.
    Citations: 7     Fields:    Translation:Humans
  36. Testa MA, Gill J, Su M, Turner RR, Blonde L, Simonson DC. Comparative effectiveness of basal-bolus versus premix analog insulin on glycemic variability and patient-centered outcomes during insulin intensification in type 1 and type 2 diabetes: a randomized, controlled, crossover trial. J Clin Endocrinol Metab. 2012 Oct; 97(10):3504-14. PMID: 22851487.
    Citations: 17     Fields:    Translation:Humans
  37. Kurbanov DB, Currie PJ, Simonson DC, Borsook D, Elman I. Effects of naltrexone on food intake and body weight gain in olanzapine-treated rats. J Psychopharmacol. 2012 Sep; 26(9):1244-51. PMID: 22723540.
    Citations: 5     Fields:    Translation:Animals
  38. Musen G, Jacobson AM, Bolo NR, Simonson DC, Shenton ME, McCartney RL, Flores VL, Hoogenboom WS. Resting-state brain functional connectivity is altered in type 2 diabetes. Diabetes. 2012 Sep; 61(9):2375-9. PMID: 22664957; PMCID: PMC3425418.
    Citations: 95     Fields:    Translation:Humans
  39. Bolo NR, Musen G, Jacobson AM, Weinger K, McCartney RL, Flores V, Renshaw PF, Simonson DC. Brain activation during working memory is altered in patients with type 1 diabetes during hypoglycemia. Diabetes. 2011 Dec; 60(12):3256-64. PMID: 21984582; PMCID: PMC3219930.
    Citations: 29     Fields:    Translation:Humans
  40. Buxton OM, Pavlova M, Reid EW, Wang W, Simonson DC, Adler GK. Sleep restriction for 1 week reduces insulin sensitivity in healthy men. Diabetes. 2010 Sep; 59(9):2126-33. PMID: 20585000; PMCID: PMC2927933.
    Citations: 226     Fields:    Translation:Humans
  41. Lyoo IK, Yoon SJ, Musen G, Simonson DC, Weinger K, Bolo N, Ryan CM, Kim JE, Renshaw PF, Jacobson AM. Altered prefrontal glutamate-glutamine-gamma-aminobutyric acid levels and relation to low cognitive performance and depressive symptoms in type 1 diabetes mellitus. Arch Gen Psychiatry. 2009 Aug; 66(8):878-87. PMID: 19652127.
    Citations: 43     Fields:    Translation:Humans
  42. Musen G, Simonson DC, Bolo NR, Driscoll A, Weinger K, Raji A, Théberge J, Renshaw PF, Jacobson AM. Regional brain activation during hypoglycemia in type 1 diabetes. J Clin Endocrinol Metab. 2008 Apr; 93(4):1450-7. PMID: 18198228; PMCID: PMC2291497.
    Citations: 20     Fields:    Translation:Humans
  43. Testa MA, Simonson DC. Satisfaction and quality of life with premeal inhaled versus injected insulin in adolescents and adults with type 1 diabetes. Diabetes Care. 2007 Jun; 30(6):1399-405. PMID: 17337493.
    Citations: 8     Fields:    Translation:Humans
  44. Raji A, Williams JS, Hopkins PN, Simonson DC, Williams GH. Familial aggregation of insulin resistance and cardiovascular risk factors in hypertension. J Clin Hypertens (Greenwich). 2006 Nov; 8(11):791-6. PMID: 17086019.
    Citations: 3     Fields:    Translation:Humans
  45. Raji A, Gerhard-Herman MD, Williams JS, O'connor ME, Simonson DC. Effect of pioglitazone on insulin sensitivity, vascular function and cardiovascular inflammatory markers in insulin-resistant non-diabetic Asian Indians. Diabet Med. 2006 May; 23(5):537-43. PMID: 16681563.
    Citations: 3     Fields:    Translation:Humans
  46. 40th EASD Annual Meeting of the European Association for the Study of Diabetes : Munich, Germany, 5-9 September 2004. Diabetologia. 2004 Aug; 47(Suppl 1):A1-A464. PMID: 27770180.
    Citations: 18     Fields:    
  47. Raji A, Gerhard-Herman MD, Warren M, Silverman SG, Raptopoulos V, Mantzoros CS, Simonson DC. Insulin resistance and vascular dysfunction in nondiabetic Asian Indians. J Clin Endocrinol Metab. 2004 Aug; 89(8):3965-72. PMID: 15292334.
    Citations: 28     Fields:    Translation:Humans
  48. Raji A, Seely EW, Bekins SA, Williams GH, Simonson DC. Rosiglitazone improves insulin sensitivity and lowers blood pressure in hypertensive patients. Diabetes Care. 2003 Jan; 26(1):172-8. PMID: 12502676.
    Citations: 37     Fields:    Translation:HumansCTClinical Trials
  49. Raji A, Seely EW, Arky RA, Simonson DC. Body fat distribution and insulin resistance in healthy Asian Indians and Caucasians. J Clin Endocrinol Metab. 2001 Nov; 86(11):5366-71. PMID: 11701707.
    Citations: 146     Fields:    Translation:HumansCTClinical Trials
  50. Weinger K, Kinsley BT, Levy CJ, Bajaj M, Simonson DC, Cox DJ, Ryan CM, Jacobson AM. The perception of safe driving ability during hypoglycemia in patients with type 1 diabetes mellitus. Am J Med. 1999 Sep; 107(3):246-53. PMID: 10492318.
    Citations: 13     Fields:    Translation:Humans
  51. 35th Annual Meeting of the European Association for the Study of Diabetes : Brussels, Belgium, 28 September-2 October 1999. Diabetologia. 1999 Aug; 42(Suppl 1):A1-A330. PMID: 27770183.
    Citations: 7     Fields:    
  52. Kinsley BT, Weinger K, Bajaj M, Levy CJ, Simonson DC, Quigley M, Cox DJ, Jacobson AM. Blood glucose awareness training and epinephrine responses to hypoglycemia during intensive treatment in type 1 diabetes. Diabetes Care. 1999 Jul; 22(7):1022-8. PMID: 10388961.
    Citations: 9     Fields:    Translation:HumansCTClinical Trials
  53. Testa MA, Turner RR, Simonson DC, Krafcik MB, Calvo C, Luque-Otero M. Quality of life and calcium channel blockade with nifedipine GITS versus amlodipine in hypertensive patients in Spain. Gastrointestinal Therapeutic System. J Hypertens. 1998 Dec; 16(12 Pt 1):1839-47. PMID: 9869019.
    Citations: 7     Fields:    Translation:Humans
  54. Testa MA, Simonson DC, Turner RR. Valuing quality of life and improvements in glycemic control in people with type 2 diabetes. Diabetes Care. 1998 Dec; 21 Suppl 3:C44-52. PMID: 9850489.
    Citations: 15     Fields:    Translation:HumansCTClinical Trials
  55. Testa MA, Simonson DC. Health economic benefits and quality of life during improved glycemic control in patients with type 2 diabetes mellitus: a randomized, controlled, double-blind trial. JAMA. 1998 Nov 04; 280(17):1490-6. PMID: 9809729.
    Citations: 80     Fields:    Translation:HumansCTClinical Trials
  56. Welt CK, Kinsley BT, Simonson DC. Recurrent hypoglycemia does not impair the cortisol response to adrenocorticotropin infusion in healthy humans. Metabolism. 1998 Oct; 47(10):1252-7. PMID: 9781630.
    Citations:    Fields:    Translation:HumansCTClinical Trials
  57. Levy CJ, Kinsley BT, Bajaj M, Simonson DC. Effect of glycemic control on glucose counterregulation during hypoglycemia in NIDDM. Diabetes Care. 1998 Aug; 21(8):1330-8. PMID: 9702443.
    Citations: 8     Fields:    Translation:Humans
  58. Battezzati A, Simonson DC, Luzi L, Matthews DE. Glucagon increases glutamine uptake without affecting glutamine release in humans. Metabolism. 1998 Jun; 47(6):713-23. PMID: 9627372.
    Citations: 6     Fields:    Translation:Humans
  59. Williams SB, Goldfine AB, Timimi FK, Ting HH, Roddy MA, Simonson DC, Creager MA. Acute hyperglycemia attenuates endothelium-dependent vasodilation in humans in vivo. Circulation. 1998 May 05; 97(17):1695-701. PMID: 9591763.
    Citations: 164     Fields:    Translation:Humans
  60. Johnston PS, Lebovitz HE, Coniff RF, Simonson DC, Raskin P, Munera CL. Advantages of alpha-glucosidase inhibition as monotherapy in elderly type 2 diabetic patients. J Clin Endocrinol Metab. 1998 May; 83(5):1515-22. PMID: 9589648.
    Citations: 21     Fields:    Translation:HumansCTClinical Trials
  61. Del Prato S, Matsuda M, Simonson DC, Groop LC, Sheehan P, Leonetti F, Bonadonna RC, DeFronzo RA. Studies on the mass action effect of glucose in NIDDM and IDDM: evidence for glucose resistance. Diabetologia. 1997 Jun; 40(6):687-97. PMID: 9222649.
    Citations: 14     Fields:    Translation:Humans
  62. Simonson DC, Kourides IA, Feinglos M, Shamoon H, Fischette CT. Efficacy, safety, and dose-response characteristics of glipizide gastrointestinal therapeutic system on glycemic control and insulin secretion in NIDDM. Results of two multicenter, randomized, placebo-controlled clinical trials. The Glipizide Gastrointestinal Therapeutic System Study Group. Diabetes Care. 1997 Apr; 20(4):597-606. PMID: 9096986.
    Citations: 27     Fields:    Translation:HumansCTClinical Trials
  63. Kinsley BT, Levy CJ, Simonson DC. Prolactin and beta-endorphin responses to hypoglycemia are reduced in well-controlled insulin-dependent diabetes mellitus. Metabolism. 1996 Nov; 45(11):1434-40. PMID: 8931651.
    Citations: 1     Fields:    Translation:Humans
  64. Bursell SE, Clermont AC, Kinsley BT, Simonson DC, Aiello LM, Wolpert HA. Retinal blood flow changes in patients with insulin-dependent diabetes mellitus and no diabetic retinopathy. Invest Ophthalmol Vis Sci. 1996 Apr; 37(5):886-97. PMID: 8603873.
    Citations: 91     Fields:    Translation:Humans
  65. Testa MA, Simonson DC. Assessment of quality-of-life outcomes. N Engl J Med. 1996 03 28; 334(13):835-40. PMID: 8596551.
    Citations: 445     Fields:    Translation:Humans
  66. Kinsley BT, Simonson DC. Evidence for a hypothalamic-pituitary versus adrenal cortical effect of glycemic control on counterregulatory hormone responses to hypoglycemia in insulin-dependent diabetes mellitus. J Clin Endocrinol Metab. 1996 Feb; 81(2):684-91. PMID: 8636289.
    Citations: 4     Fields:    Translation:Humans
  67. Goldfine AB, Simonson DC, Folli F, Patti ME, Kahn CR. In vivo and in vitro studies of vanadate in human and rodent diabetes mellitus. Mol Cell Biochem. 1995 Dec 6-20; 153(1-2):217-31. PMID: 8927042.
    Citations: 25     Fields:    Translation:HumansAnimals
  68. Goldfine AB, Simonson DC, Folli F, Patti ME, Kahn CR. Metabolic effects of sodium metavanadate in humans with insulin-dependent and noninsulin-dependent diabetes mellitus in vivo and in vitro studies. J Clin Endocrinol Metab. 1995 Nov; 80(11):3311-20. PMID: 7593444.
    Citations: 33     Fields:    Translation:HumansCTClinical Trials
  69. Draelos MT, Jacobson AM, Weinger K, Widom B, Ryan CM, Finkelstein DM, Simonson DC. Cognitive function in patients with insulin-dependent diabetes mellitus during hyperglycemia and hypoglycemia. Am J Med. 1995 Feb; 98(2):135-44. PMID: 7847430.
    Citations: 24     Fields:    Translation:HumansCTClinical Trials
  70. Weinger K, Jacobson AM, Draelos MT, Finkelstein DM, Simonson DC. Blood glucose estimation and symptoms during hyperglycemia and hypoglycemia in patients with insulin-dependent diabetes mellitus. Am J Med. 1995 Jan; 98(1):22-31. PMID: 7825615.
    Citations: 10     Fields:    Translation:HumansCTClinical Trials
  71. Kinsley BT, Widom B, Simonson DC. Differential regulation of counterregulatory hormone secretion and symptoms during hypoglycemia in IDDM. Effect of glycemic control. Diabetes Care. 1995 Jan; 18(1):17-26. PMID: 7698043.
    Citations: 3     Fields:    Translation:Humans
  72. Gaboury CL, Simonson DC, Seely EW, Hollenberg NK, Williams GH. Relation of pressor responsiveness to angiotensin II and insulin resistance in hypertension. J Clin Invest. 1994 Dec; 94(6):2295-300. PMID: 7989585; PMCID: PMC330057.
    Citations: 8     Fields:    Translation:HumansCells
  73. Kinsley BT, Widom B, Utzschneider K, Simonson DC. Stimulus specificity of defects in counterregulatory hormone secretion in insulin-dependent diabetes mellitus: effect of glycemic control. J Clin Endocrinol Metab. 1994 Nov; 79(5):1383-9. PMID: 7962332.
    Citations: 4     Fields:    Translation:HumansCTClinical Trials
  74. Del Prato S, Leonetti F, Simonson DC, Sheehan P, Matsuda M, DeFronzo RA. Effect of sustained physiologic hyperinsulinaemia and hyperglycaemia on insulin secretion and insulin sensitivity in man. Diabetologia. 1994 Oct; 37(10):1025-35. PMID: 7851681.
    Citations: 81     Fields:    Translation:HumansCTClinical Trials
  75. Bonadonna RC, Groop LC, Simonson DC, DeFronzo RA. Free fatty acid and glucose metabolism in human aging: evidence for operation of the Randle cycle. Am J Physiol. 1994 Mar; 266(3 Pt 1):E501-9. PMID: 8166272.
    Citations: 20     Fields:    Translation:HumansCells
  76. Kaye TB, Guay AT, Simonson DC. Non-insulin-dependent diabetes mellitus and elevated serum ferritin level. J Diabetes Complications. 1993 Oct-Dec; 7(4):246-9. PMID: 8219368.
    Citations: 7     Fields:    Translation:Humans
  77. Wolpert HA, Steen SN, Istfan NW, Simonson DC. Insulin modulates circulating endothelin-1 levels in humans. Metabolism. 1993 Aug; 42(8):1027-30. PMID: 8345807.
    Citations: 13     Fields:    Translation:Humans
  78. Donovan DS, Solomon CG, Seely EW, Williams GH, Simonson DC. Effect of sodium intake on insulin sensitivity. Am J Physiol. 1993 May; 264(5 Pt 1):E730-4. PMID: 8498495.
    Citations: 28     Fields:    Translation:Humans
  79. Widom B, Simonson DC. Intermittent hypoglycemia impairs glucose counterregulation. Diabetes. 1992 Dec; 41(12):1597-602. PMID: 1446801.
    Citations: 18     Fields:    Translation:Humans
  80. Wolpert HA, Steen SN, Istfan NW, Simonson DC. Disparate effects of weight loss on insulin sensitivity and erythrocyte sodium-lithium countertransport activity. Am J Hypertens. 1992 Oct; 5(10):754-7. PMID: 1418840.
    Citations: 3     Fields:    Translation:HumansCells
  81. Groop LC, Bonadonna RC, Simonson DC, Petrides AS, Shank M, DeFronzo RA. Effect of insulin on oxidative and nonoxidative pathways of free fatty acid metabolism in human obesity. Am J Physiol. 1992 Jul; 263(1 Pt 1):E79-84. PMID: 1636701.
    Citations: 26     Fields:    Translation:HumansCells
  82. Kaye TB, Rubin RA, Goldfine AB, Rajamani K, Kinsley BT, Vischer UM, Simonson DC. Effect of glycemic control on the overnight dexamethasone suppression test in patients with diabetes mellitus. J Clin Endocrinol Metab. 1992 Mar; 74(3):640-4. PMID: 1740499.
    Citations: 5     Fields:    Translation:Humans
  83. Widom B, Diamond MP, Simonson DC. Alterations in glucose metabolism during menstrual cycle in women with IDDM. Diabetes Care. 1992 Feb; 15(2):213-20. PMID: 1547678.
    Citations: 10     Fields:    Translation:Humans
  84. DeFronzo RA, Barzilai N, Simonson DC. Mechanism of metformin action in obese and lean noninsulin-dependent diabetic subjects. J Clin Endocrinol Metab. 1991 Dec; 73(6):1294-301. PMID: 1955512.
    Citations: 79     Fields:    Translation:Humans
  85. Simonson DC, Dzau VJ. Workshop IX--Lipids, insulin, diabetes. Am J Med. 1991 Feb 21; 90(2A):85S-86S. PMID: 1994726.
    Citations: 1     Fields:    Translation:Humans
  86. Groop LC, Ratheiser K, Luzi L, Melander A, Simonson DC, Petrides A, Bonadonna RC, Widén E, DeFronzo RA. Effect of sulphonylurea on glucose-stimulated insulin secretion in healthy and non-insulin dependent diabetic subjects: a dose-response study. Acta Diabetol. 1991; 28(2):162-8. PMID: 1777653.
    Citations: 10     Fields:    Translation:HumansCTClinical Trials
  87. Simonson DC. Diabetes and hypertension: new concepts in treatment. Trends Endocrinol Metab. 1990 Sep-Oct; 1(7):329-34. PMID: 18411140.
    Citations:    Fields:    
  88. Simonson DC. Effects of glyburide on in vivo insulin-mediated glucose disposal. Am J Med. 1990 Aug 20; 89(2A):44S-50S; discussion 51S-53S. PMID: 2117389.
    Citations: 1     Fields:    Translation:Humans
  89. Widom B, Simonson DC. Glycemic control and neuropsychologic function during hypoglycemia in patients with insulin-dependent diabetes mellitus. Ann Intern Med. 1990 Jun 15; 112(12):904-12. PMID: 2187391.
    Citations: 34     Fields:    Translation:Humans
  90. Simonson DC, DeFronzo RA. Indirect calorimetry: methodological and interpretative problems. Am J Physiol. 1990 Mar; 258(3 Pt 1):E399-412. PMID: 2180312.
    Citations: 86     Fields:    Translation:Humans
  91. Luzi L, Castellino P, Simonson DC, Petrides AS, DeFronzo RA. Leucine metabolism in IDDM. Role of insulin and substrate availability. Diabetes. 1990 Jan; 39(1):38-48. PMID: 2210059.
    Citations: 12     Fields:    Translation:Humans
  92. Simonson DC. Hyperinsulinemia and its sequelae. Horm Metab Res Suppl. 1990; 22:17-25. PMID: 2202624.
    Citations: 3     Fields:    Translation:HumansCells
  93. Diamond MP, Simonson DC, DeFronzo RA. Menstrual cyclicity has a profound effect on glucose homeostasis. Fertil Steril. 1989 Aug; 52(2):204-8. PMID: 2666174.
    Citations: 16     Fields:    Translation:Humans
  94. Caprio S, Plewe G, Diamond MP, Simonson DC, Boulware SD, Sherwin RS, Tamborlane WV. Increased insulin secretion in puberty: a compensatory response to reductions in insulin sensitivity. J Pediatr. 1989 Jun; 114(6):963-7. PMID: 2524556.
    Citations: 70     Fields:    Translation:Humans
  95. DeFronzo RA, Ferrannini E, Simonson DC. Fasting hyperglycemia in non-insulin-dependent diabetes mellitus: contributions of excessive hepatic glucose production and impaired tissue glucose uptake. Metabolism. 1989 Apr; 38(4):387-95. PMID: 2657323.
    Citations: 120     Fields:    Translation:Humans
  96. Simonson DC. Etiology and prevalence of hypertension in diabetic patients. Diabetes Care. 1988 Nov-Dec; 11(10):821-7. PMID: 3073072.
    Citations: 25     Fields:    Translation:Humans
  97. Golay A, DeFronzo RA, Ferrannini E, Simonson DC, Thorin D, Acheson K, Thiébaud D, Curchod B, Jéquier E, Felber JP. Oxidative and non-oxidative glucose metabolism in non-obese type 2 (non-insulin-dependent) diabetic patients. Diabetologia. 1988 Aug; 31(8):585-91. PMID: 3065112.
    Citations: 24     Fields:    Translation:HumansCells
  98. Amiel SA, Sherwin RS, Simonson DC, Tamborlane WV. Effect of intensive insulin therapy on glycemic thresholds for counterregulatory hormone release. Diabetes. 1988 Jul; 37(7):901-7. PMID: 3290007.
    Citations: 93     Fields:    Translation:Humans
  99. Merkel PA, Simonson DC, Amiel SA, Plewe G, Sherwin RS, Pearson HA, Tamborlane WV. Insulin resistance and hyperinsulinemia in patients with thalassemia major treated by hypertransfusion. N Engl J Med. 1988 Mar 31; 318(13):809-14. PMID: 3281000.
    Citations: 48     Fields:    Translation:Humans
  100. Simonson DC, Tappy L, Jequier E, Felber JP, DeFronzo RA. Normalization of carbohydrate-induced thermogenesis by fructose in insulin-resistant states. Am J Physiol. 1988 Feb; 254(2 Pt 1):E201-7. PMID: 3279802.
    Citations: 13     Fields:    Translation:HumansCells
  101. Testa MA, Simonson DC. Measuring quality of life in hypertensive patients with diabetes. Postgrad Med J. 1988; 64 Suppl 3:50-8; discussion 90-2. PMID: 3249717.
    Citations: 9     Fields:    Translation:Humans
  102. Simonson DC. Insulin sensitivity and the effects of antihypertensive agents: implications for the treatment of hypertension in the patient with diabetes mellitus. Postgrad Med J. 1988; 64 Suppl 3:39-47; discussion 48-9. PMID: 3074296.
    Citations: 3     Fields:    Translation:Humans
  103. Ferrannini E, Simonson DC, Katz LD, Reichard G, Bevilacqua S, Barrett EJ, Olsson M, DeFronzo RA. The disposal of an oral glucose load in patients with non-insulin-dependent diabetes. Metabolism. 1988 Jan; 37(1):79-85. PMID: 3275860.
    Citations: 92     Fields:    Translation:Humans
  104. Castellino P, Luzi L, Simonson DC, Haymond M, DeFronzo RA. Effect of insulin and plasma amino acid concentrations on leucine metabolism in man. Role of substrate availability on estimates of whole body protein synthesis. J Clin Invest. 1987 Dec; 80(6):1784-93. PMID: 3316280; PMCID: PMC442454.
    Citations: 57     Fields:    Translation:HumansCells
  105. Groop L, Luzi L, Melander A, Groop PH, Ratheiser K, Simonson DC, DeFronzo RA. Different effects of glyburide and glipizide on insulin secretion and hepatic glucose production in normal and NIDDM subjects. Diabetes. 1987 Nov; 36(11):1320-8. PMID: 3117609.
    Citations: 19     Fields:    Translation:Humans
  106. Amiel SA, Simonson DC, Sherwin RS, Lauritano AA, Tamborlane WV. Exaggerated epinephrine responses to hypoglycemia in normal and insulin-dependent diabetic children. J Pediatr. 1987 Jun; 110(6):832-7. PMID: 3585599.
    Citations: 8     Fields:    Translation:Humans
  107. Amiel SA, Tamborlane WV, Simonson DC, Sherwin RS. Defective glucose counterregulation after strict glycemic control of insulin-dependent diabetes mellitus. N Engl J Med. 1987 May 28; 316(22):1376-83. PMID: 3553949.
    Citations: 82     Fields:    Translation:Humans
  108. Amiel SA, Simonson DC, Tamborlane WV, DeFronzo RA, Sherwin RS. Rate of glucose fall does not affect counterregulatory hormone responses to hypoglycemia in normal and diabetic humans. Diabetes. 1987 Apr; 36(4):518-22. PMID: 3817305.
    Citations: 19     Fields:    Translation:Humans
  109. Del Prato S, Castellino P, Simonson DC, DeFronzo RA. Hyperglucagonemia and insulin-mediated glucose metabolism. J Clin Invest. 1987 Feb; 79(2):547-56. PMID: 3543054; PMCID: PMC424124.
    Citations: 16     Fields:    Translation:Humans
  110. Simonson DC, Delprato S, Castellino P, Groop L, DeFronzo RA. Effect of glyburide on glycemic control, insulin requirement, and glucose metabolism in insulin-treated diabetic patients. Diabetes. 1987 Feb; 36(2):136-46. PMID: 3100365.
    Citations: 8     Fields:    Translation:Humans
  111. Castellino P, Simonson DC, DeFronzo RA. Adrenergic modulation of potassium metabolism during exercise in normal and diabetic humans. Am J Physiol. 1987 Jan; 252(1 Pt 1):E68-76. PMID: 3544863.
    Citations: 3     Fields:    Translation:Humans
  112. Amiel SA, Sherwin RS, Simonson DC, Lauritano AA, Tamborlane WV. Impaired insulin action in puberty. A contributing factor to poor glycemic control in adolescents with diabetes. N Engl J Med. 1986 Jul 24; 315(4):215-9. PMID: 3523245.
    Citations: 210     Fields:    Translation:Humans
  113. Tappy L, Randin JP, Felber JP, Chiolero R, Simonson DC, Jequier E, DeFronzo RA. Comparison of thermogenic effect of fructose and glucose in normal humans. Am J Physiol. 1986 Jun; 250(6 Pt 1):E718-24. PMID: 3521319.
    Citations: 34     Fields:    Translation:HumansCells
  114. Thorin D, Golay A, Simonson DC, Jéquier E, Felber JP, DeFronzo RA. The effect of selective beta adrenergic blockade on glucose-induced thermogenesis in man. Metabolism. 1986 Jun; 35(6):524-8. PMID: 3520212.
    Citations: 2     Fields:    Translation:HumansCells
  115. Bevilacqua S, Barrett EJ, Smith D, Simonson DC, Olsson M, Bratusch-Marrain P, Ferrannini E, DeFronzo RA. Hepatic and peripheral insulin resistance following streptozotocin-induced insulin deficiency in the dog. Metabolism. 1985 Sep; 34(9):817-25. PMID: 3897768.
    Citations: 9     Fields:    Translation:AnimalsCells
  116. Simonson DC, Tamborlane WV, DeFronzo RA, Sherwin RS. Intensive insulin therapy reduces counterregulatory hormone responses to hypoglycemia in patients with type I diabetes. Ann Intern Med. 1985 Aug; 103(2):184-90. PMID: 3893253.
    Citations: 26     Fields:    Translation:Humans
  117. Simonson DC, Tamborlane WV, Sherwin RS, Smith JD, DeFronzo RA. Improved insulin sensitivity in patients with type I diabetes mellitus after CSII. Diabetes. 1985 Aug; 34 Suppl 3:80-6. PMID: 3894130.
    Citations: 11     Fields:    Translation:HumansCells
  118. Testa MA, Puklin JE, Sherwin RS, Simonson DC. Clinical predictors of retinopathy and its progression in patients with type I diabetes during CSII or conventional insulin treatment. Diabetes. 1985 Aug; 34 Suppl 3:61-8. PMID: 3894129.
    Citations: 6     Fields:    Translation:HumansCTClinical Trials
  119. Testa MA, Simonson DC. The design and structure of clinical research information systems. Implications for data retrieval and statistical analyses. J Med Syst. 1985 Jun; 9(3):109-19. PMID: 3840516.
    Citations: 1     Fields:    Translation:Humans
  120. Simonson DC, Ferrannini E, Bevilacqua S, Smith D, Barrett E, Carlson R, DeFronzo RA. Mechanism of improvement in glucose metabolism after chronic glyburide therapy. Diabetes. 1984 Sep; 33(9):838-45. PMID: 6432610.
    Citations: 30     Fields:    Translation:HumansCells
  121. Simonson DC, Koivisto V, Sherwin RS, Ferrannini E, Hendler R, Juhlin-Dannfelt A, DeFronzo RA. Adrenergic blockade alters glucose kinetics during exercise in insulin-dependent diabetics. J Clin Invest. 1984 Jun; 73(6):1648-58. PMID: 6327767; PMCID: PMC437075.
    Citations: 8     Fields:    Translation:Humans
  122. DeFronzo RA, Simonson DC. Oral sulfonylurea agents suppress hepatic glucose production in non-insulin-dependent diabetic individuals. Diabetes Care. 1984 May-Jun; 7 Suppl 1:72-80. PMID: 6428844.
    Citations: 12     Fields:    Translation:Humans
  123. DeFronzo RA, Simonson D. Diabetes in the elderly: not just "normal aging". Geriatrics. 1984 May; 39(5):16, 19. PMID: 6714676.
    Citations:    Fields:    Translation:Humans
  124. DeFronzo RA, Thorin D, Felber JP, Simonson DC, Thiebaud D, Jequier E, Golay A. Effect of beta and alpha adrenergic blockade on glucose-induced thermogenesis in man. J Clin Invest. 1984 Mar; 73(3):633-9. PMID: 6368584; PMCID: PMC425062.
    Citations: 16     Fields:    Translation:Humans
  125. Simonson DC, DeFronzo RA. Glucagon physiology and aging: evidence for enhanced hepatic sensitivity. Diabetologia. 1983 Jul; 25(1):1-7. PMID: 6884612.
    Citations: 5     Fields:    Translation:Humans
  126. DeFronzo RA, Simonson D, Ferrannini E. Hepatic and peripheral insulin resistance: a common feature of type 2 (non-insulin-dependent) and type 1 (insulin-dependent) diabetes mellitus. Diabetologia. 1982 Oct; 23(4):313-9. PMID: 6754515.
    Citations: 132     Fields:    Translation:Humans
  127. DeFronzo RA, Hendler R, Simonson D. Insulin resistance is a prominent feature of insulin-dependent diabetes. Diabetes. 1982 Sep; 31(9):795-801. PMID: 6761214.
    Citations: 108     Fields:    Translation:Humans
  128. Simonson D, DeFronzo RA. Hypophosphatemia and glucose intolerance. Adv Exp Med Biol. 1982; 151:217-28. PMID: 6758518.
    Citations: 2     Fields:    Translation:Humans
  129. Defronzo RA, Simonson D, Ferrannini E, Barrett E. Insulin resistance: a universal finding in diabetic states. Bull Schweiz Akad Med Wiss. 1981-1982; 223-38. PMID: 6820936.
    Citations: 8     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.